Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhigh voltage-gated calcium channel activity

CACNA1B CACNA1F CACNA1S

7.85e-0614573GO:0008331
GeneOntologyMolecularFunctionvoltage-gated calcium channel activity

CACNA1B CACNA1F CACNA1S

3.07e-0446573GO:0005245
GeneOntologyMolecularFunctiongated channel activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2

3.71e-04334576GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2

4.27e-04343576GO:0005261
GeneOntologyMolecularFunctioncalcium channel activity

CACNA1B CACNA1F CACNA1S RYR2

5.04e-04129574GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

CACNA1B CACNA1F CACNA1S RYR2

9.09e-04151574GO:0015085
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1B CACNA1F CACNA1S KCNJ10

9.32e-04152574GO:0022843
GeneOntologyMolecularFunctionpolypeptide N-acetylgalactosaminyltransferase activity

GALNT6 GALNT13

1.47e-0320572GO:0004653
GeneOntologyMolecularFunctionpromoter-specific chromatin binding

BMI1 EHMT2 CHD7

1.72e-0383573GO:1990841
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1B CACNA1F CACNA1S KCNJ10

1.81e-03182574GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1B CACNA1F CACNA1S KCNJ10

1.88e-03184574GO:0022832
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2

1.92e-03459576GO:0005216
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2 SLC45A4

1.97e-03627577GO:0022890
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2

2.05e-03465576GO:0046873
GeneOntologyMolecularFunctioncalcium/calmodulin-dependent protein kinase activity

PHKA1 MAPKAPK5

2.68e-0327572GO:0004683
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2 SLC45A4

2.72e-03664577GO:0008324
GeneOntologyMolecularFunctionchannel activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2

3.74e-03525576GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2

3.78e-03526576GO:0022803
GeneOntologyMolecularFunctionactin filament binding

CTNNAL1 CYFIP1 ABL2 NEB

4.01e-03227574GO:0051015
GeneOntologyMolecularFunctioncalmodulin binding

PHKA1 CACNA1S MAPKAPK5 RYR2

4.20e-03230574GO:0005516
GeneOntologyBiologicalProcessregulation of SA node cell action potential

ANK2 RYR2

2.33e-053582GO:0098907
GeneOntologyBiologicalProcesscalcium ion transmembrane import into cytosol

CACNA1B CACNA1F CACNA1S ANK2 CHD7 RYR2

3.25e-05217586GO:0097553
GeneOntologyBiologicalProcessregulation of atrial cardiac muscle cell action potential

ANK2 RYR2

4.65e-054582GO:0098910
GeneOntologyBiologicalProcessregulation of AV node cell action potential

ANK2 RYR2

7.73e-055582GO:0098904
GeneOntologyBiologicalProcessregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

ANK2 CHD7 RYR2

1.08e-0433583GO:0010880
GeneOntologyBiologicalProcesspositive regulation of glycogen catabolic process

ADCY10 PHKA1

1.16e-046582GO:0045819
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by sarcoplasmic reticulum

ANK2 CHD7 RYR2

1.53e-0437583GO:0014808
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol by endoplasmic reticulum

ANK2 CHD7 RYR2

1.79e-0439583GO:1903514
GeneOntologyBiologicalProcesscellular response to alkaloid

CACNA1S EHMT2 RYR2

1.94e-0440583GO:0071312
GeneOntologyBiologicalProcessregulation of actin filament-based process

ADCY10 CYFIP1 ABL2 ANK2 CARMIL3 NEB RYR2

2.19e-04438587GO:0032970
GeneOntologyBiologicalProcessregulation of cardiac muscle cell contraction

ADCY10 ANK2 RYR2

2.40e-0443583GO:0086004
GeneOntologyBiologicalProcesssarcoplasmic reticulum calcium ion transport

ANK2 CHD7 RYR2

2.57e-0444583GO:0070296
GeneOntologyBiologicalProcesscalcium ion import across plasma membrane

CACNA1B CACNA1F CACNA1S

3.34e-0448583GO:0098703
GeneOntologyBiologicalProcesscalcium ion import into cytosol

CACNA1B CACNA1F CACNA1S

3.34e-0448583GO:1902656
GeneOntologyBiologicalProcessprotein O-linked glycosylation via threonine

GALNT6 GALNT13

3.45e-0410582GO:0018243
GeneOntologyBiologicalProcessSA node cell to atrial cardiac muscle cell signaling

ANK2 RYR2

3.45e-0410582GO:0086018
GeneOntologyBiologicalProcessSA node cell action potential

ANK2 RYR2

3.45e-0410582GO:0086015
GeneOntologyBiologicalProcessadult walking behavior

ABL2 KCNJ10 CHD7

3.77e-0450583GO:0007628
GeneOntologyBiologicalProcesscellular response to caffeine

CACNA1S RYR2

4.21e-0411582GO:0071313
GeneOntologyBiologicalProcessSA node cell to atrial cardiac muscle cell communication

ANK2 RYR2

4.21e-0411582GO:0086070
GeneOntologyBiologicalProcessregulation of actin filament-based movement

ADCY10 ANK2 RYR2

4.47e-0453583GO:1903115
GeneOntologyBiologicalProcessAV node cell to bundle of His cell signaling

ANK2 RYR2

5.04e-0412582GO:0086027
GeneOntologyBiologicalProcessAV node cell action potential

ANK2 RYR2

5.04e-0412582GO:0086016
GeneOntologyBiologicalProcesswalking behavior

ABL2 KCNJ10 CHD7

6.44e-0460583GO:0090659
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1B CACNA1F CACNA1S KCNJ10

6.85e-04142584GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1B CACNA1F CACNA1S KCNJ10

6.85e-04142584GO:0098659
GeneOntologyBiologicalProcessregulation of glycogen catabolic process

ADCY10 PHKA1

6.92e-0414582GO:0005981
GeneOntologyBiologicalProcesscellular response to purine-containing compound

CACNA1S RYR2

6.92e-0414582GO:0071415
GeneOntologyBiologicalProcesssmall GTPase-mediated signal transduction

CTNNAL1 CYFIP1 ABL2 ABR TRIO HACE1 MAPKAPK5

7.51e-04538587GO:0007264
GeneOntologyBiologicalProcessrelease of sequestered calcium ion into cytosol

CACNA1S ANK2 CHD7 RYR2

7.60e-04146584GO:0051209
GeneOntologyBiologicalProcessnegative regulation of sequestering of calcium ion

CACNA1S ANK2 CHD7 RYR2

7.79e-04147584GO:0051283
GeneOntologyBiologicalProcessAV node cell to bundle of His cell communication

ANK2 RYR2

7.97e-0415582GO:0086067
GeneOntologyBiologicalProcesscalcium ion transmembrane transport

CACNA1B CACNA1F CACNA1S ANK2 CHD7 RYR2

7.97e-04392586GO:0070588
GeneOntologyBiologicalProcessregulation of sequestering of calcium ion

CACNA1S ANK2 CHD7 RYR2

8.20e-04149584GO:0051282
GeneOntologyBiologicalProcesssequestering of calcium ion

CACNA1S ANK2 CHD7 RYR2

9.05e-04153584GO:0051208
GeneOntologyCellularComponentcalcium channel complex

CACNA1B CACNA1F CACNA1S RYR2

5.03e-0573584GO:0034704
GeneOntologyCellularComponentcentral region of growth cone

ADCY10 CYFIP1

1.57e-047582GO:0090724
GeneOntologyCellularComponentvoltage-gated calcium channel complex

CACNA1B CACNA1F CACNA1S

2.83e-0446583GO:0005891
HumanPhenoAbnormal urine potassium concentration

CACNA1S KCNJ10 NDUFAF6

4.07e-0518203HP:0012598
HumanPhenoAbnormal blood cation concentration

ADCY10 CACNA1S ANK2 TRIO KCNJ10 HACE1 NDUFAF6 CHD7

7.44e-05401208HP:0010929
HumanPhenoAbnormal blood inorganic cation concentration

ADCY10 CACNA1S TRIO KCNJ10 NDUFAF6 CHD7

1.28e-04216206HP:0010927
HumanPhenoAbsent radius

FANCE TRIO CHD7

1.43e-0427203HP:0003974
HumanPhenoAbnormal blood ion concentration

ADCY10 CACNA1S ANK2 TRIO KCNJ10 HACE1 NDUFAF6 CHD7

1.56e-04445208HP:0003111
HumanPhenoAbsent forearm bone

FANCE TRIO CHD7

1.59e-0428203HP:0003953
HumanPhenoAplasia involving forearm bones

FANCE TRIO CHD7

1.59e-0428203HP:0009822
HumanPhenoHypokalemia

CACNA1S ANK2 KCNJ10 NDUFAF6

2.15e-0479204HP:0002900
MousePhenodecreased embryonic neuroepithelium thickness

ELOA CTNNAL1 CHD7

3.42e-0520453MP:0012703
MousePhenodecreased brain internal capsule size

ANK2 CHD7

6.05e-054452MP:0012462
MousePhenodecreased startle reflex

CACNA1B RELCH ABL2 RIOK3 CHD7 FBXO30

7.65e-05224456MP:0001489
DomainVDCC_a1su_IQ

CACNA1B CACNA1F CACNA1S

9.35e-077573IPR014873
DomainGPHH

CACNA1B CACNA1F CACNA1S

9.35e-077573PF16905
DomainGPHH_dom

CACNA1B CACNA1F CACNA1S

9.35e-077573IPR031649
DomainCa_chan_IQ

CACNA1B CACNA1F CACNA1S

9.35e-077573SM01062
DomainCa_chan_IQ

CACNA1B CACNA1F CACNA1S

9.35e-077573PF08763
DomainVDCCAlpha1

CACNA1B CACNA1F CACNA1S

3.19e-0610573IPR002077
DomainVDCC_L_a1su

CACNA1F CACNA1S

5.47e-054572IPR005446
DomainIon_trans_dom

CACNA1B CACNA1F CACNA1S RYR2

4.05e-04114574IPR005821
DomainIon_trans

CACNA1B CACNA1F CACNA1S RYR2

4.05e-04114574PF00520
DomainZnf_TRAF

TRAF4 FBXO30

5.92e-0412572IPR001293
DomainZF_TRAF

TRAF4 FBXO30

6.99e-0413572PS50145
DomainChannel_four-helix_dom

CACNA1B CACNA1F CACNA1S

7.02e-0457573IPR027359
Domain-

CACNA1B CACNA1F CACNA1S

7.02e-04575731.20.120.350
Domain-

TRAF4 FBXO30

8.13e-04145723.90.890.10
DomainSIAH-type

TRAF4 FBXO30

1.07e-0316572IPR013323
DomainTRAF-like

TRAF4 FBXO30

2.42e-0324572IPR008974
DomainRicin_B_lectin

GALNT6 GALNT13

2.62e-0325572PF00652
DomainRICIN

GALNT6 GALNT13

3.29e-0328572SM00458
DomainRICIN_B_LECTIN

GALNT6 GALNT13

3.29e-0328572PS50231
DomainRicin_B_lectin

GALNT6 GALNT13

3.77e-0330572IPR000772
DomainGlycos_transf_2

GALNT6 GALNT13

3.77e-0330572PF00535
DomainGlyco_trans_2-like

GALNT6 GALNT13

3.77e-0330572IPR001173
DomainDNA/RNA_helicase_DEAH_CS

CHD7 DHX33

5.10e-0335572IPR002464
DomainDEAH_ATP_HELICASE

CHD7 DHX33

6.00e-0338572PS00690
DomainGDS_CDC24_CS

ABR TRIO

6.31e-0339572IPR001331
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1B CACNA1F CACNA1S

5.64e-076443M47762
PathwayKEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY

CACNA1B CACNA1S RYR2

4.60e-0611443M47958
PathwayKEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY

CACNA1B CACNA1F CACNA1S

4.81e-0523443M47666
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL

CACNA1B CACNA1F CACNA1S

6.22e-0525443M47948
PathwayREACTOME_RAC3_GTPASE_CYCLE

CYFIP1 ABL2 ABR TRIO

1.97e-0493444MM15609
PathwayREACTOME_RAC3_GTPASE_CYCLE

CYFIP1 ABL2 ABR TRIO

2.05e-0494444M41818
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

CACNA1B PHKA1 CACNA1F CACNA1S RYR2

2.21e-04178445M2890
PathwayWP_15Q112_COPY_NUMBER_VARIATION_SYNDROME

CYFIP1 TUBGCP3

3.38e-049442M39879
Pubmed

Evolutionary insights into T-type Ca2+ channel structure, function, and ion selectivity from the Trichoplax adhaerens homologue.

CACNA1B CACNA1F CACNA1S

2.45e-07858328330839
Pubmed

International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.

CACNA1B CACNA1F CACNA1S

3.67e-07958316382099
Pubmed

Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.

CACNA1B CACNA1F CACNA1S

1.97e-061558320188150
Pubmed

Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.

CACNA1B CACNA1F CACNA1S

1.97e-061558324453333
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

CCND3 BMI1 ELOA ACSM3 EHMT2 PRSS27 RIOK3 GALNT6 GALNT13

3.20e-0673058934857952
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1B CACNA1F CACNA1S KCNJ10 RYR2

3.67e-0613958516985003
Pubmed

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

CACNA1B ANK2

8.19e-06358224394417
Pubmed

Postmortem genetic analysis of sudden unexplained death syndrome under 50 years of age: A next-generation sequencing study.

ANK2 RYR2

8.19e-06358227005929
Pubmed

Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.

CACNA1F CACNA1S

1.64e-05458220937870
Pubmed

Voltage-Gated Ion Channels Are Transcriptional Targets of Sox10 during Oligodendrocyte Development.

CACNA1B KCNJ10

2.72e-05558238995010
Pubmed

Distinct roles for CARMIL isoforms in cell migration.

TRIO CARMIL3

2.72e-05558219846667
Pubmed

Convergence of BMI1 and CHD7 on ERK Signaling in Medulloblastoma.

BMI1 CHD7

2.72e-05558229212025
Pubmed

The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.

PHKA1 WAPL CYFIP1 TRIO RMND1

2.83e-0521258533853758
Pubmed

Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.

CACNA1B CACNA1F RYR2

3.56e-053858330786075
Pubmed

Structural biology of human H3K9 methyltransferases.

ACSM3 EHMT2

4.08e-05658220084102
Pubmed

Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.

CACNA1F CACNA1S

5.71e-05758212900400
Pubmed

Noncoding Microdeletion in Mouse Hgf Disrupts Neural Crest Migration into the Stria Vascularis, Reduces the Endocochlear Potential, and Suggests the Neuropathology for Human Nonsyndromic Deafness DFNB39.

HGF KCNJ10

5.71e-05758232152201
Pubmed

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.

CYFIP1 ABR ANK2 TRIO KCNJ10

6.31e-0525158527507650
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

CYFIP1 ABL2 ANK2 TRIO KCNJ10

1.07e-0428158528706196
Pubmed

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.

CACNA1S RYR2

1.22e-041058218434328
Pubmed

Abi1 is essential for the formation and activation of a WAVE2 signalling complex.

CYFIP1 NEB

1.22e-041058215048123
Pubmed

Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

KLHL13 HACE1 CHD7 MARCHF4

1.27e-0415358410718198
Pubmed

A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.

PHKA1 ANK2 RMND1

1.41e-046058319075228
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ANK2 TRIO EHMT2 TUBGCP3 RIOK3 NEB

1.78e-0449758623414517
Pubmed

Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing.

HGF KCNJ10

2.11e-041358227488639
Pubmed

Ikaros confers early temporal competence to mouse retinal progenitor cells.

CCND3 IKZF4

2.11e-041358218940586
Pubmed

Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.

CACNA1F ABL2 ABR ANK2 EHMT2

2.23e-0432958517474147
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

CCND3 BMI1 CARMIL3 AGFG1 ATP11C CHD7

3.13e-0455258610737800
Pubmed

Esophageal Atresia / Tracheoesophageal Fistula Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

FANCE CHD7

3.23e-041658220301753
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

CCND3 CYFIP1 TRIO EHMT2 CHD7

3.29e-0435858532460013
Pubmed

The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.

CYFIP1 CHD7 DHX33 RYR2

3.34e-0419758420811636
Pubmed

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.

CCND3 HGF TRAF4 ABL2 MAPKAPK5

3.87e-0437158525241761
Pubmed

Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.

BMI1 HGF

4.11e-041858214607778
Pubmed

Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation.

BMI1 MAPKAPK5

4.11e-041858221675959
Pubmed

Congenital heart defect causing mutation in Nkx2.5 displays in vivo functional deficit.

CACNA1S RYR2

5.62e-042158228302382
Pubmed

The DNA sequence and analysis of human chromosome 6.

CCND3 FANCE HACE1 RMND1 DNAH8 FBXO30

5.87e-0462258614574404
Pubmed

Overexpression of Galnt3 in chondrocytes resulted in dwarfism due to the increase of mucin-type O-glycans and reduction of glycosaminoglycans.

GALNT6 GALNT13

6.18e-042258225107907
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

CRYL1 CTNNAL1 CYFIP1 CHD7 NEB RYR2

6.71e-0463858631182584
Pubmed

Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.

GALNT6 GALNT13

7.37e-042458231882545
Pubmed

Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding.

GALNT6 GALNT13

7.37e-042458231740596
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

CCND3 PHKA1 CYFIP1 ABL2 ABR TRIO MAPKAPK5

7.73e-0491058736736316
Pubmed

Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.

EHMT2 NEB

8.66e-042658223892084
Pubmed

Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.

ZCCHC18 TCAIM ANK2 EHMT2 HACE1 NDUFAF6 MMS19 GALNT13

8.82e-04121558815146197
Pubmed

USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.

PHKA1 ZCCHC18 PRSS27 PRAMEF20 ASIC4 MARCHF4

8.91e-0467458637196079
Pubmed

Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.

DNAH8 GALNT13

9.34e-042758218649358
Pubmed

Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.

NEB RYR2

9.34e-042758218468998
Pubmed

Binding of the proline-rich segment of myelin basic protein to SH3 domains: spectroscopic, microarray, and modeling studies of ligand conformation and effects of posttranslational modifications.

ABL2 NEB

1.00e-032858218067320
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

CYFIP1 ABR ANK2 TRIO EHMT2 KCNJ10 CHD7

1.07e-0396358728671696
Pubmed

Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.

CACNA1B PHKA1 TRIO CARMIL3 TUBGCP3

1.18e-0347558531040226
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

BMI1 EHMT2 MMS19 CHD7

1.27e-0328258423667531
Pubmed

A human MAP kinase interactome.

ABL2 AGFG1 NEB MAPKAPK5 FBXO30

1.30e-0348658520936779
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

ELOA WAPL TRIO AGFG1 SMG9 CHD7

1.37e-0373358634672954
Pubmed

Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library.

CCND3 EHMT2

1.40e-033358223718855
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

CACNA1B CACNA1S

1.40e-033358222357600
Pubmed

The p300/YY1/miR-500a-5p/HDAC2 signalling axis regulates cell proliferation in human colorectal cancer.

ELOA TRIO TUBGCP3 AGFG1

1.56e-0329858430737378
Pubmed

Galnt1 is required for normal heart valve development and cardiac function.

GALNT6 GALNT13

1.66e-033658225615642
Cytoband1q23.2

KCNJ10 OR10J1

9.09e-04355821q23.2
CytobandEnsembl 112 genes in cytogenetic band chr2q23

NEB GALNT13

2.07e-0353582chr2q23
Cytoband12q13

GALNT6 IKZF4

3.69e-037158212q13
CytobandEnsembl 112 genes in cytogenetic band chr6p21

CCND3 FANCE EHMT2 DNAH8

3.79e-03503584chr6p21
Cytoband2q35

ASIC4 MARCHF4

4.54e-03795822q35
GeneFamilyCalcium voltage-gated channel subunits

CACNA1B CACNA1F CACNA1S

2.92e-0526423253
GeneFamilyPolypeptide N-acetylgalactosaminyltransferases

GALNT6 GALNT13

9.75e-0420422433
CoexpressionGSE27786_CD4_TCELL_VS_ERYTHTROBLAST_UP

ABL2 AGFG1 MMS19 CHD7 DHX33 DNAH8

4.33e-06200566M4827
CoexpressionGSE15930_STIM_VS_STIM_AND_IL12_48H_CD8_T_CELL_DN

CCND3 TRAF4 PTPRK MMS19 CHD7 IKZF4

4.33e-06200566M3631
ToppCellmild-B_intermediate|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TRAF4 ANK2 PTPRK CHD7 DNAH8

6.25e-062005858e3132a1fe3708f725c5c4077878fb87bbea3678
ToppCellmild-B_intermediate|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TRAF4 ANK2 PTPRK CHD7 DNAH8

6.25e-06200585fe815824e9e4be3f3db73610e3814a7fd533da65
ToppCell343B-Myeloid-Macrophage-FABP4+_Macrophage_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

FANCE RIMKLB PTPRK CARMIL3

6.49e-05166584f4698fd08965936d51695d571bd10fb77330d916
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1B ANK2 MARCHF4 GALNT13

6.96e-05169584b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellP07-Epithelial-epithelial_progenitor_cell-epithelial_unknown_3|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

CTNNAL1 KCNJ10 GALNT6 NEB

7.45e-051725848d6a2a0d5f63b09a5a304a77e600a647f87e9de4
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Plasma_cells-IgA_plasma_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHKA1 ZCCHC18 CACNA1F NEB

7.62e-0517358409cd878c33534bd476d6a4880f5582076189da8c
ToppCell5'-Adult-Distal_Rectal-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PHKA1 ZCCHC18 CACNA1F NEB

7.62e-0517358462abaaaf48cabd1423f17fb27c33b75ea88867f4
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B-Branch_B1_(eMN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1B CACNA1F ANK2 ASIC4

8.14e-05176584bfea433544c6d6b8ad55e50ca94c5574460c2e0b
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-neurons_B|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1B CACNA1F ANK2 ASIC4

8.14e-051765843c78dee7e1111a579fde6d401b9ecb4d5b8e782f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

CACNA1B TRAF4 TRIO KCNJ10

8.32e-0517758437d1abe1a9d8f2b8f4d146bbf1db94104eab6593
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF4 RIMKLB CTNNAL1 TRIO

9.07e-051815844e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF4 RIMKLB CTNNAL1 TRIO

9.07e-05181584ad30c01290fb98adbd0caed301a584761212c977
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TRAF4 RIMKLB CTNNAL1 TRIO

9.07e-051815843a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

CACNA1B ANK2 MARCHF4 GALNT13

9.27e-0518258457bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CTNNAL1 KLHL13 KCNJ10 CHD7

9.27e-05182584ecb5624c9074cc6449fad961df54c926c2681d54
ToppCelldroplet-Heart-HEART_(LV+RV_ONLY)-30m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZCCHC18 CARMIL3 KCNJ10 GALNT6

9.47e-051835848330c39184ce076e1f95fd3725b68af551d89db0
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F NEB GALNT13 RYR2

9.67e-05184584ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F NEB GALNT13 RYR2

9.67e-051845842cbed6462fea2622871bb7e49b0df3d984239281
ToppCellfacs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1F NEB GALNT13 RYR2

9.67e-051845842b19a8c5f823e00812908b23e66bb4e563278aff
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

CCND3 TRIO KLHL13 RYR2

9.67e-05184584d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1B ANK2 MARCHF4 GALNT13

1.01e-04186584b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1B ANK2 MARCHF4 GALNT13

1.05e-04188584c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell21-Trachea-Epithelial-Neuroendocrine|Trachea / Age, Tissue, Lineage and Cell class

ANK2 NEB MARCHF4 GALNT13

1.05e-04188584e78d4f7a5d28c77503cb041ff585d13df4c88bd2
ToppCellhuman_hepatoblastoma-Endothelial_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

RIMKLB CYYR1 ATP11C SLC45A4

1.14e-04192584e09f609fed033a25baacaf4a07bbbae1076da366
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

TRAF4 PTPRK CHD7 DNAH8

1.19e-041945842b61023a602d336ed0de174e9141046173db34e6
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

TRAF4 TRIO CHD7 GALNT13

1.19e-04194584920955e775617d6156c5ee8b90d2cecd01a70e12
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TRAF4 PTPRK CHD7 DNAH8

1.19e-04194584f2486b19ac52a48d19f80b38a5536bee3dad745b
DrugCNS 1145

CACNA1B CACNA1F CACNA1S RYR2

1.37e-0633574CID000190902
DrugIHC-64

CACNA1B CACNA1F CACNA1S RYR2

1.37e-0633574CID000162753
Drugisradipine

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

5.16e-06100575CID000003784
DrugKW-3049

CACNA1B HGF CACNA1F CACNA1S

7.46e-0650574CID000002324
DrugVerapamil

CACNA1B CACNA1F CACNA1S

8.14e-0616573DB00661
Drugbaclofen

ADCY10 CACNA1B CACNA1F CACNA1S KCNJ10 RYR2

8.19e-06191576CID000002284
Druglamotrigine

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

1.07e-05116575CID000003878
DrugCinildipine

CACNA1B CACNA1F CACNA1S RYR2

1.18e-0556574CID000002752
Drugnilvadipine

CACNA1B CACNA1F CACNA1S RYR2

1.55e-0560574CID000004494
Drugbepridil

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

1.59e-05126575CID000002351
DrugIAA-94

CACNA1B CACNA1F CACNA1S RYR2

1.66e-0561574CID000003667
Druglercanidipine

CACNA1B CACNA1F CACNA1S RYR2

1.88e-0563574CID000065866
Druggallopamil

CACNA1B CACNA1F CACNA1S RYR2

2.41e-0567574CID000001234
DrugAC1L2AC7

CACNA1B CACNA1F CACNA1S RYR2

2.70e-0569574CID000068733
DrugCAS 298-57-7

CACNA1B CACNA1F CACNA1S RYR2

3.38e-0573574CID000002761
Drugethosuximide

CACNA1B CACNA1F CACNA1S RYR2

3.56e-0574574CID000003291
Drugprocaine

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

4.05e-05153575CID000004914
Druglindane

CACNA1B HGF CACNA1F CACNA1S RYR2

4.18e-05154575CID000000727
Drugnisoldipine

CACNA1B CACNA1F CACNA1S RYR2

4.39e-0578574CID000004499
DrugN-cyclopentyl-N-cyclobutylformamide

CACNA1B CACNA1F CACNA1S RYR2

4.61e-0579574CID005287890
Druggabapentin

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

6.51e-05169575CID000003446
Druglavendustin A

CACNA1B HGF CACNA1F CACNA1S RYR2

6.88e-05171575CID000003894
Drugriluzole

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

7.47e-05174575CID000005070
Drugchloro-m-cresol

CACNA1S RYR2

9.18e-056572CID000012008
DrugNSC114784

CACNA1S RYR2

9.18e-056572CID000419425
DrugNSC7524

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

9.24e-05182575CID000005657
Drugmanidipine

CACNA1B CACNA1F CACNA1S RYR2

9.48e-0595574CID000004008
Drugisotetrandrine

CACNA1B CACNA1F CACNA1S RYR2

1.03e-0497574CID000005422
Drugnitrendipine

CACNA1B CACNA1F CACNA1S RYR2

1.07e-0498574CID000004507
Drugdihydropyridine

CACNA1B CACNA1F CACNA1S ANK2 RYR2

1.22e-04193575CID000104822
DrugAmlodipine

CACNA1B CACNA1S

1.28e-047572DB00381
DrugHydroxytacrine maleate (R,S) [118909-22-1]; Up 200; 12.2uM; PC3; HT_HG-U133A

ADCY10 HGF ABL2 ANK2 TRIO

1.37e-041985756651_UP
Drugloperamide

CACNA1B CACNA1F CACNA1S RYR2

1.40e-04105574CID000003954
Druggadolinium

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

1.40e-04199575CID000023982
Drugkenpaullone

CCND3 CACNA1B MAPKAPK5

1.71e-0443573CID000003820
Drugh PM

CACNA1B CACNA1S ABR

1.96e-0445573CID005494424
DrugAC1NBU2S

CACNA1B CACNA1F CACNA1S RYR2

2.12e-04117574CID004473765
Drugverapamil

ADCY10 CACNA1B CACNA1F CACNA1S KCNJ10 ASIC4 RYR2

2.14e-04490577CID000002520
DrugCinnarizine

CACNA1F CACNA1S

2.19e-049572DB00568
DrugNimodipine

CACNA1F CACNA1S

2.19e-049572DB00393
Drugphenytoin

CACNA1B CACNA1F CACNA1S ASIC4 RYR2

2.19e-04219575CID000001775
Drugheliotrine

SLC22A9 ACSM3 NEB

2.38e-0448573ctd:C010178
DiseaseTimothy syndrome (implicated_via_orthology)

CACNA1F CACNA1S

2.04e-054552DOID:0060173 (implicated_via_orthology)
DiseaseDuchenne muscular dystrophy (implicated_via_orthology)

CACNA1F CACNA1S CTNNAL1

4.19e-0536553DOID:11723 (implicated_via_orthology)
DiseaseVENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC, 1 (disorder)

ANK2 RYR2

1.52e-0410552C1631597
DiseaseCongenital myopathy (disorder)

CACNA1S NEB

2.22e-0412552C0270960
DiseaseLeukemia, Myelocytic, Acute

FANCE HGF TRIO EHMT2

3.08e-04173554C0023467
DiseaseMHPG measurement, 5-HIAA measurement

CCND3 KLHL13

4.56e-0417552EFO_0005132, EFO_0005133
DiseaseHVA measurement

CYYR1 NDUFAF6

1.08e-0326552EFO_0005131
DiseaseAcute Myeloid Leukemia, M1

HGF TRIO EHMT2

1.66e-03125553C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

HGF TRIO EHMT2

1.66e-03125553C1879321

Protein segments in the cluster

PeptideGeneStartEntry
AAKENCMMHLLRSLP

ABR

751

Q12979
QCVQREIKPHMRKML

CCND3

46

P30281
RMAMTLPRNCQRSKL

ABL2

796

P42684
ALMVLCETHRARMVK

EHMT2

476

Q96KQ7
IECHRIRFCNPMMQK

ADCY10

921

Q96PN6
CPARVAYKRLVRMNM

CACNA1B

1766

Q00975
LLNTMMELRKCCNHP

CHD7

1241

Q9P2D1
RHCNRAPLTHKMNKM

HERV-K104

16

P61576
CRLVKRHRLATMPPM

ANK2

1006

Q01484
EKSVMLMLGRCLPHI

RELCH

516

Q9P260
HRVACKRLVAMNMPL

CACNA1F

1501

O60840
TLMEVMPKICRLPRH

CYFIP1

951

Q7L576
RPKARNEVRLHMMCA

MAPKAPK5

56

Q8IW41
NGKPCLMIRVANMRK

KCNJ10

191

P78508
MCMKNHRATRVGILR

CYYR1

86

Q96J86
PSMAVRIAALQCMHA

MMS19

966

Q96T76
VVKLMRGLLHCMIRQ

PHKA1

81

P46020
KRYLRCPAAMTVMHL

BMI1

161

P35226
CPAAMTVMHLRKFLR

BMI1

166

P35226
LCPVAMRVAEGHNKM

CARMIL3

781

Q8ND23
ICKPLHYLTIMSRRM

OR4K3

126

Q96R72
RRKVFLPMDICMLHG

NDUFAF6

226

Q330K2
LMKAQTECGRPHREM

DNAH8

2141

Q96JB1
QMKSLLRIVRMFCHV

HACE1

316

Q8IYU2
RKGHMCNAKLLRNMP

TUBGCP3

681

Q96CW5
AVLQRCHCRMVHMPG

ASIC4

326

Q96FT7
PLVCEQHKMRMVLGV

HGF

676

P14210
RLNGPVIMLKCHHMR

GALNT13

486

Q8IUC8
IQKAPMTTVRGLHCM

KLHL13

516

Q9P2N7
MMLLTASKTCLRHPN

CTNNAL1

236

Q9UBT7
LPKMMTLHQQCIRVL

ELOA

571

Q14241
HRVACKRLVGMNMPL

CACNA1S

1441

Q13698
RRHMPLRLAMVGCAF

GALNT6

6

Q8NCL4
RAQLRDICLKMSMPI

DHX33

596

Q9H6R0
MLRHQGLLKCRCRML

MARCHF4

31

Q9P2E8
RTHALMKKIGQCPMR

CRYL1

171

Q9Y2S2
PRICQRNLMSLLMAV

FANCE

91

Q9HB96
MARNKVAEHLEMCPA

FBXO30

71

Q8TB52
ICGQLRPSMMQHLLR

RYR2

2576

Q92736
MVCIGPNVLMVHKRS

IKZF4

166

Q9H2S9
CLPRNHDKNRFMDML

PTPRK

1196

Q15262
AICNPLRYMVIMNKR

OR10J1

136

P30954
VVMKPRHCLLMLLGS

OR1L6

171

Q8NGR2
MFCHLRPMRRLCLEK

TCAIM

1

Q8N3R3
PSLCEMLHMPNICKR

SLC22A9

336

Q8IVM8
MLHMPNICKRISLLS

SLC22A9

341

Q8IVM8
ARRCLPNAMMNRKPL

PRAMEF20

121

Q5VT98
REDFCPRKLRQMHLM

SMG9

376

Q9H0W8
GRRVKVMNEKLQHCM

RMND1

396

Q9NWS8
MLARVTRKMLRHAKC

ACSM3

1

Q53FZ2
MLRDMTGLPHNRKCF

AGFG1

16

P52594
CRMAPLQKAQIVRMV

ATP11C

791

Q8NB49
KEMHNLARMQRAGIP

RIOK3

331

O14730
MLKMPRELMRLCLCH

SLC45A4

501

Q5BKX6
KAATACGRPRMLNRM

PRSS27

21

Q9BQR3
LATKCAMPSFRMHLR

WAPL

681

Q7Z5K2
VLRHLEKMGCRLMNR

RIMKLB

91

Q9ULI2
PHLAMMCALVSRQRQ

TRAF4

276

Q9BUZ4
RSLCPLVVKMAERNM

ZCCHC18

31

P0CG32
VMLSVPKRANDAMHL

TRIO

1456

O75962
IPNDMMNHVLAKRCQ

NEB

4546

P20929