Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	Roundabout binding	MYO9B RTN4R IGFALS	2.16e-05	12	94	3	GO:0048495
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNHD1 APPBP2 MYO9B MYO3B DNAH9	2.39e-04	118	94	5	GO:0003774
GeneOntologyCellularComponent	microtubule associated complex	DNHD1 APPBP2 LRP8 SPTBN5 CCDC65 DNAH9	7.85e-05	161	92	6	GO:0005875
GeneOntologyCellularComponent	axonemal dynein complex	DNHD1 CCDC65 DNAH9	1.77e-04	25	92	3	GO:0005858
Domain	Leu-rich_rpt	LRRC8E TCTE1 MXRA5 CARMIL2 RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 LRFN4 IGFALS AMIGO3 LGI2 PRAME RABGGTA NLRP13	6.87e-16	271	90	18	IPR001611
Domain	-	LRRC8E TCTE1 MXRA5 CARMIL2 RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 LRFN4 IGFALS AMIGO3 LGI2 PRAME RABGGTA NLRP13	1.32e-14	321	90	18	3.80.10.10
Domain	L_dom-like	LRRC8E TCTE1 MXRA5 CARMIL2 RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 LRFN4 IGFALS AMIGO3 LGI2 PRAME RABGGTA NLRP13	1.91e-14	328	90	18	IPR032675
Domain	LRR_8	LRRC8E MXRA5 RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 LRFN4 IGFALS AMIGO3 LGI2	1.79e-12	171	90	13	PF13855
Domain	LRR_1	LRRC8E RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 LRFN4 IGFALS AMIGO3 LGI2 PRAME RABGGTA	2.52e-12	219	90	14	PF00560
Domain	Leu-rich_rpt_typical-subtyp	LRRC8E MXRA5 RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 LRFN4 IGFALS AMIGO3 LGI2	2.78e-12	177	90	13	IPR003591
Domain	LRR_TYP	LRRC8E MXRA5 RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 LRFN4 IGFALS AMIGO3 LGI2	2.78e-12	177	90	13	SM00369
Domain	LRRNT	MXRA5 RTN4R LRRC32 LINGO2 LGR5 LRRN3 LRFN4 IGFALS AMIGO3	1.03e-09	98	90	9	IPR000372
Domain	LRRNT	MXRA5 RTN4R LRRC32 LINGO2 LGR5 LRRN3 LRFN4 IGFALS AMIGO3	1.03e-09	98	90	9	SM00013
Domain	LRR	LRRC8E RTN4R LRRC32 LINGO2 LRRC58 LGR5 TLR10 LRRN3 IGFALS AMIGO3 RABGGTA	3.38e-09	201	90	11	PS51450
Domain	Cys-rich_flank_reg_C	MXRA5 RTN4R LINGO2 TLR10 LRRN3 LRFN4 IGFALS LGI2	1.19e-08	90	90	8	IPR000483
Domain	LRRCT	MXRA5 RTN4R LINGO2 TLR10 LRRN3 LRFN4 IGFALS LGI2	1.19e-08	90	90	8	SM00082
Domain	LRRNT	LRRC32 LINGO2 LGR5 LRRN3 IGFALS AMIGO3	2.02e-07	53	90	6	PF01462
Domain	Mib_Herc2	MIB2 MIB1	1.37e-04	4	90	2	IPR010606
Domain	MIB_HERC2	MIB2 MIB1	1.37e-04	4	90	2	PS51416
Domain	MIB_HERC2	MIB2 MIB1	1.37e-04	4	90	2	PF06701
Domain	Spectrin	SPTA1 SPTBN5 SYNE2	1.79e-04	23	90	3	PF00435
Domain	Spectrin_repeat	SPTA1 SPTBN5 SYNE2	3.61e-04	29	90	3	IPR002017
Domain	Spectrin/alpha-actinin	SPTA1 SPTBN5 SYNE2	4.85e-04	32	90	3	IPR018159
Domain	SPEC	SPTA1 SPTBN5 SYNE2	4.85e-04	32	90	3	SM00150
Domain	Dynein_HC_stalk	DNHD1 DNAH9	2.01e-03	14	90	2	IPR024743
Domain	Dynein_heavy_dom-2	DNHD1 DNAH9	2.01e-03	14	90	2	IPR013602
Domain	DHC_N2	DNHD1 DNAH9	2.01e-03	14	90	2	PF08393
Domain	MT	DNHD1 DNAH9	2.01e-03	14	90	2	PF12777
Domain	DHC_fam	DNHD1 DNAH9	2.31e-03	15	90	2	IPR026983
Domain	Dynein_heavy_dom	DNHD1 DNAH9	2.31e-03	15	90	2	IPR004273
Domain	Dynein_heavy	DNHD1 DNAH9	2.31e-03	15	90	2	PF03028
Domain	LY	LRP8 ROS1	2.31e-03	15	90	2	SM00135
Domain	LDLR_classB_rpt	LRP8 ROS1	2.31e-03	15	90	2	IPR000033
Domain	LRR_6	TCTE1 CARMIL2 NLRP13	2.37e-03	55	90	3	PF13516
Domain	ZZ	MIB2 MIB1	3.34e-03	18	90	2	PF00569
Domain	ZF_ZZ_2	MIB2 MIB1	3.34e-03	18	90	2	PS50135
Domain	ZF_ZZ_1	MIB2 MIB1	3.34e-03	18	90	2	PS01357
Domain	Znf_ZZ	MIB2 MIB1	3.72e-03	19	90	2	IPR000433
Domain	ZnF_ZZ	MIB2 MIB1	3.72e-03	19	90	2	SM00291
Domain	UDPGT	UGT1A4 UGT1A3	4.54e-03	21	90	2	PF00201
Domain	UDPGT	UGT1A4 UGT1A3	4.54e-03	21	90	2	PS00375
Domain	UDP_glucos_trans	UGT1A4 UGT1A3	4.54e-03	21	90	2	IPR002213
Domain	CH	CFAP47 SPTBN5 SYNE2	4.69e-03	70	90	3	PF00307
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	DNHD1 MXRA5 SPTA1 ANKRD36B SPTBN5 CELSR3 SYNE2 ANKRD36	5.77e-08	187	97	8	26460568
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LINGO2 LRRN3 LRFN4 AMIGO3	2.47e-06	34	97	4	18848646
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	CFAP47 APPBP2 MXRA5 TOPAZ1 ARHGEF33 GTF3C1 EXOC3L4 MYO3B ALDH18A1 CA5A DOP1B	6.76e-06	736	97	11	29676528
Pubmed	Targeted disruption of Mib2 causes exencephaly with a variable penetrance.	MIB2 MIB1	7.70e-06	2	97	2	17987667
Pubmed	Human UGT1A4 and UGT1A3 conjugate 25-hydroxyvitamin D3: metabolite structure, kinetics, inducibility, and interindividual variability.	UGT1A4 UGT1A3	7.70e-06	2	97	2	24641623
Pubmed	The anaphase promoting complex is required for memory function in mice.	APC2 ANAPC2	7.70e-06	2	97	2	21191042
Pubmed	Subtle Deregulation of the Wnt-Signaling Pathway Through Loss of Apc2 Reduces the Fitness of Intestinal Stem Cells.	APC2 LGR5	7.70e-06	2	97	2	29027285
Pubmed	The TTYH3/MK5 Positive Feedback Loop regulates Tumor Progression via GSK3-β/β-catenin signaling in HCC.	TTYH3 MAPKAPK5	7.70e-06	2	97	2	35844789
Pubmed	FHOD1 interaction with nesprin-2G mediates TAN line formation and nuclear movement.	FHOD1 SYNE2	7.70e-06	2	97	2	24880667
Pubmed	N-glucuronidation of nicotine and cotinine by human liver microsomes and heterologously expressed UDP-glucuronosyltransferases.	UGT1A4 UGT1A3	7.70e-06	2	97	2	14570768
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	PEX1 IRAK1 ANKRD36C MAPKAPK5 ANKRD36B GTF3C1 ANAPC1 CDK13 ANAPC2 PKN1 ANKRD36 DDX60L	8.89e-06	910	97	12	36736316
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E SZT2 MYO9B IRAK1 LAMB2 ELP6 MIB2 TTYH3 MAPKAPK5 ITPR3 CELSR3 CDK13 PKN1	1.24e-05	1105	97	13	35748872
Pubmed	Interactome of the Autoimmune Risk Protein ANKRD55.	NCAPD3 CAD PPP3CA MIB1 ALDH18A1 MMS19	1.97e-05	197	97	6	31620119
Pubmed	Defining the membrane proteome of NK cells.	NCAPD3 EXOSC10 CAD GLT8D1 CARMIL2 MYO9B LRP8 ITPR3 GTF3C1 FHOD1 MMS19 CHID1 IMMT	2.21e-05	1168	97	13	19946888
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	NCAPD3 CAD MYO9B ITPR3 ANAPC1 MMS19	2.27e-05	202	97	6	33005030
Pubmed	Rescue of calcineurin Aα(-/-) mice reveals a novel role for the α isoform in the salivary gland.	ITPR3 PPP3CA	2.31e-05	3	97	2	21435446
Pubmed	Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle.	APC2 ANAPC2	2.31e-05	3	97	2	12471060
Pubmed	Mind bomb-2 is an E3 ligase for Notch ligand.	MIB2 MIB1	2.31e-05	3	97	2	15824097
Pubmed	Virus-inducible IGFALS facilitates innate immune responses by mediating IRAK1 and TRAF6 activation.	IRAK1 IGFALS	2.31e-05	3	97	2	33664485
Pubmed	Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.	FHOD1 SYNE2	2.31e-05	3	97	2	33472039
Pubmed	Human UDP-glucuronosyltransferase (UGT) 2B10 in drug N-glucuronidation: substrate screening and comparison with UGT1A3 and UGT1A4.	UGT1A4 UGT1A3	2.31e-05	3	97	2	23611809
Pubmed	Cytoplasmic Metadherin (MTDH) provides survival advantage under conditions of stress by acting as RNA-binding protein.	FAM184A TCIRG1 ITPR3 SPTBN5 PKN1 DOP1B	3.14e-05	214	97	6	22199357
Pubmed	Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation.	ANAPC1 ANAPC2	4.60e-05	4	97	2	11438673
Pubmed	Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals.	IRAK1 ROS1	4.60e-05	4	97	2	18566305
Pubmed	Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8.	UGT1A4 UGT1A3	4.60e-05	4	97	2	9535849
Pubmed	Differential expression of the UGT1A locus in human liver, biliary, and gastric tissue: identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue.	UGT1A4 UGT1A3	4.60e-05	4	97	2	9271343
Pubmed	DNA cloning using in vitro site-specific recombination.	LRRC8E RNF32 EVC2 PDE6C RTN4R IRAK1 MIB2 LRRC58 PALS1 PPP3CA	7.65e-05	794	97	10	11076863
Pubmed	Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.	HDAC5 PKN1	7.66e-05	5	97	2	20188095
Pubmed	Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.	IRAK1 TLR10	7.66e-05	5	97	2	16537705
Pubmed	The BH4 domain of Bcl-2 inhibits ER calcium release and apoptosis by binding the regulatory and coupling domain of the IP3 receptor.	ITPR3 PPP3CA	7.66e-05	5	97	2	19706527
Pubmed	Variation of hepatic glucuronidation: Novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4.	UGT1A4 UGT1A3	7.66e-05	5	97	2	15057901
Pubmed	Loss of DRC1 function leads to multiple morphological abnormalities of the sperm flagella and male infertility in human and mouse.	TCTE1 CCDC65	7.66e-05	5	97	2	34169321
Pubmed	Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.	MYT1L LRP8 LRRN3 MIB1	8.42e-05	82	97	4	31073041
Pubmed	Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.	LRRC32 TLR10 ANAPC1	9.84e-05	32	97	3	23817571
Pubmed	Analysis of inherited genetic variations at the UGT1 locus in the French-Canadian population.	UGT1A4 UGT1A3	1.15e-04	6	97	2	19204906
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	APPBP2 CAD IRAK1 ANAPC1 CDK13 ANAPC2 IMMT	1.36e-04	401	97	7	25852190
Pubmed	SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.	APPBP2 PRAME	1.60e-04	7	97	2	26138980
Pubmed	The E3 ubiquitin ligase mind bomb-2 (MIB2) protein controls B-cell CLL/lymphoma 10 (BCL10)-dependent NF-κB activation.	MIB2 MIB1	1.60e-04	7	97	2	21896478
Pubmed	Embryogenic stem cell-derived intestinal crypt fission directs de novo crypt genesis.	HNF4A LGR5	1.60e-04	7	97	2	36516755
Pubmed	APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.	ANAPC1 ANAPC2	1.60e-04	7	97	2	21768287
Pubmed	Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes.	ITPR3 PPP3CA	1.60e-04	7	97	2	22495310
Pubmed	mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.	LRP8 GTF3C1 FHOD1 SYNE2	1.68e-04	98	97	4	34943047
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	EXOSC10 TBRG4 FAM91A1 ANAPC1 ANAPC2 ALDH18A1 MMS19 IMMT	1.77e-04	560	97	8	35241646
Pubmed	SUMO targets the APC/C to regulate transition from metaphase to anaphase.	FAM91A1 ANAPC1 ANAPC2	2.08e-04	41	97	3	29549242
Pubmed	Oligomerization of the UDP-glucuronosyltransferase 1A proteins: homo- and heterodimerization analysis by fluorescence resonance energy transfer and co-immunoprecipitation.	UGT1A4 UGT1A3	2.13e-04	8	97	2	17179145
Pubmed	The transcription factor Sox5 modulates Sox10 function during melanocyte development.	SOX13 MITF	2.13e-04	8	97	2	18703590
Pubmed	Alternatively spliced products of the UGT1A gene interact with the enzymatically active proteins to inhibit glucuronosyltransferase activity in vitro.	UGT1A4 UGT1A3	2.13e-04	8	97	2	20610558
Pubmed	Involvement of human UGT2B7 and 2B15 in rofecoxib metabolism.	UGT1A4 UGT1A3	2.13e-04	8	97	2	12695355
Pubmed	Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine.	HNF4A LGR5	2.13e-04	8	97	2	21113154
Pubmed	Simultaneous evaluation of six human glucuronidation activities in liver microsomes using liquid chromatography-tandem mass spectrometry.	UGT1A4 UGT1A3	2.13e-04	8	97	2	22579593
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	CAD PEX1 LAMB2 FAM91A1 GTF3C1 MMS19	2.52e-04	313	97	6	38270169
Pubmed	A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.	UGT1A4 UGT1A3	2.74e-04	9	97	2	22511988
Pubmed	Sumoylation promotes optimal APC/C Activation and Timely Anaphase.	APC2 ANAPC2	2.74e-04	9	97	2	29517484
Pubmed	A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini.	UGT1A4 UGT1A3	2.74e-04	9	97	2	1339448
Pubmed	Schizophrenia and vitamin D related genes could have been subject to latitude-driven adaptation.	PPP3CA MITF	2.74e-04	9	97	2	21070662
Pubmed	Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.	MYO9B IRAK1 GTF3C1 ALDH18A1 MMS19	3.21e-04	211	97	5	17314511
Pubmed	Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons.	ANAPC1 ANAPC2	3.41e-04	10	97	2	10500174
Pubmed	Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.	UGT1A4 UGT1A3	3.41e-04	10	97	2	23642732
Pubmed	UDP-glucuronosyltransferases.	UGT1A4 UGT1A3	3.41e-04	10	97	2	11465080
Pubmed	Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex.	ANAPC1 ANAPC2	3.41e-04	10	97	2	10318877
Pubmed	A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.	UGT1A4 UGT1A3	3.41e-04	10	97	2	23371916
Pubmed	A genome-wide association study of total bilirubin and cholelithiasis risk in sickle cell anemia.	UGT1A4 UGT1A3	3.41e-04	10	97	2	22558097
Pubmed	Sox13 is a novel early marker for hair follicle development.	LGR5 SOX13	3.41e-04	10	97	2	30638933
Pubmed	Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins.	LINGO2 LRRN3 AMIGO3	4.21e-04	52	97	3	24613359
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	NCAPD3 TBRG4 MXRA5 POT1 ITPR3 ANKRD36B SYNE2 MIB1	4.24e-04	638	97	8	31182584
Pubmed	A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.	NCAPD3 CAD GTF3C1 FHOD1	4.26e-04	125	97	4	21654808
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	NCAPD3 PEX1 FAM91A1 MIB2 PALS1 GTF3C1 CDK13 ANAPC2	4.79e-04	650	97	8	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	EXOSC10 CAD ITPR3 GTF3C1 ANAPC1 SYNE2 ALDH18A1 IMMT	4.94e-04	653	97	8	22586326
Pubmed	The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.	LGR5 LRP8	4.99e-04	12	97	2	30146491
Pubmed	Mitotic regulation of the human anaphase-promoting complex by phosphorylation.	ANAPC1 ANAPC2	4.99e-04	12	97	2	14657031
Pubmed	Role of UDP-glucuronosyltransferase isoforms in 13-cis retinoic acid metabolism in humans.	UGT1A4 UGT1A3	4.99e-04	12	97	2	20308471
Pubmed	Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.	UGT1A4 UGT1A3	4.99e-04	12	97	2	19419973
Pubmed	Detoxification enzyme polymorphisms are not involved in duodenal adenomatosis in familial adenomatous polyposis.	UGT1A4 UGT1A3	4.99e-04	12	97	2	18161889
Pubmed	Localization of the coactivator Cdh1 and the cullin subunit Apc2 in a cryo-electron microscopy model of vertebrate APC/C.	ANAPC1 ANAPC2	4.99e-04	12	97	2	16364912
Pubmed	Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus.	UGT1A4 UGT1A3	4.99e-04	12	97	2	11434514
Pubmed	Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.	PDE6C PEX1 PALS1 SYNE2 MITF	5.05e-04	233	97	5	32290105
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	TBRG4 CAD GTF3C1 CDK13 ANAPC2 PKN1 BBLN	5.32e-04	503	97	7	16964243
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ELP6 MIB2 VWA7 CELSR3 CDK13 DNAH9	5.36e-04	361	97	6	26167880
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNHD1 NCAPD3 CARMIL2 GTF3C1 ANAPC1 CDK13 ANAPC2 IMMT	5.84e-04	670	97	8	22990118
Pubmed	The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20.	ANAPC1 ANAPC2	5.89e-04	13	97	2	23979597
Pubmed	The extracellular matrix controls stem cell specification and crypt morphology in the developing and adult mouse gut.	LAMB2 LGR5	5.89e-04	13	97	2	36350252
Pubmed	UGT1A1 is a major locus influencing bilirubin levels in African Americans.	UGT1A4 UGT1A3	5.89e-04	13	97	2	22085899
Pubmed	Genome-wide analysis of hepatic lipid content in extreme obesity.	UGT1A4 UGT1A3	5.89e-04	13	97	2	25246029
Pubmed	Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.	ANAPC1 ANAPC2	5.89e-04	13	97	2	16921029
Pubmed	Retinal degeneration mutants in the mouse.	PDE6C MITF	5.89e-04	13	97	2	11853768
Pubmed	Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.	UGT1A4 UGT1A3	6.85e-04	14	97	2	21646302
Pubmed	Human UDP-glucuronosyltransferases: metabolism, expression, and disease.	UGT1A4 UGT1A3	6.85e-04	14	97	2	10836148
Pubmed	General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions.	HNF4A LGR5	6.85e-04	14	97	2	36639541
Pubmed	Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.	IRAK1 TLR10	6.85e-04	14	97	2	14625308
Pubmed	Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.	UGT1A4 UGT1A3	6.85e-04	14	97	2	14672974
Pubmed	DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.	PDE6C MITF	6.85e-04	14	97	2	21297615
Pubmed	Deubiquitylase USP9X suppresses tumorigenesis by stabilizing large tumor suppressor kinase 2 (LATS2) in the Hippo pathway.	ANAPC1 ANAPC2	6.85e-04	14	97	2	29183995
Pubmed	Characterization of vertebrate cohesin complexes and their regulation in prophase.	ANAPC1 ANAPC2	6.85e-04	14	97	2	11076961
Pubmed	The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.	UGT1A4 UGT1A3	6.85e-04	14	97	2	9295054
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NCAPD3 TBRG4 SZT2 CELSR3 AMIGO3 ANAPC2 MIB1	7.15e-04	529	97	7	14621295
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	NCAPD3 EXOSC10 CAD IRAK1 PPP3CA GTF3C1 ANAPC1 ALDH18A1 MMS19 PRAME IMMT	7.64e-04	1257	97	11	37317656
Pubmed	Iris phenotypes and pigment dispersion caused by genes influencing pigmentation.	MITF RABGGTA	7.89e-04	15	97	2	18715234
Pubmed	The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex.	ANAPC1 ANAPC2	7.89e-04	15	97	2	10922056
Pubmed	APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.	ANAPC1 ANAPC2	7.89e-04	15	97	2	23007861
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	NCAPD3 GTF3C1 ALDH18A1 IMMT	8.44e-04	150	97	4	30154076
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	GLT8D1 TOPAZ1 LAMB2 ELP6 CELSR3 AMIGO3	5.92e-05	316	97	6	chr3p21
Cytoband	Ensembl 112 genes in cytogenetic band chr2q11	ANKRD36C ANKRD36B ANKRD36 GPAT2	3.23e-04	153	97	4	chr2q11
Cytoband	3p21.31	TOPAZ1 ELP6 CELSR3	1.27e-03	100	97	3	3p21.31
Cytoband	2q11.1	ANKRD36C GPAT2	1.61e-03	28	97	2	2q11.1
Cytoband	2q37	UGT1A4 UGT1A3	1.97e-03	31	97	2	2q37
Cytoband	3p21	LAMB2 AMIGO3	2.24e-03	33	97	2	3p21
Cytoband	7p13	TBRG4 CDK13	3.11e-03	39	97	2	7p13
GeneFamily	EF-hand domain containing\|Spectrins	SPTA1 SPTBN5	2.56e-04	7	64	2	1113
GeneFamily	Dynein regulatory complex	TCTE1 CCDC65	6.65e-04	11	64	2	981
GeneFamily	Anaphase promoting complex \|Tetratricopeptide repeat domain containing	ANAPC1 ANAPC2	1.09e-03	14	64	2	402
GeneFamily	Ankyrin repeat domain containing	MIB2 ANKRD36C ANKRD36B MIB1 ANKRD36	1.65e-03	242	64	5	403
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	MIB2 MIB1	1.82e-03	18	64	2	91
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MXRA5 LINGO2 LRRN3 LRFN4	2.54e-03	161	64	4	593
GeneFamily	UDP glucuronosyltransferases	UGT1A4 UGT1A3	5.71e-03	32	64	2	363
ToppCell	10x5'-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	CFAP47 FAM184A ANKRD36B SYNE2 ANKRD36 DNAH9	1.13e-06	156	96	6	10d191e29b16cae8238e8df6c0ff38882253f34e
Drug	N-Fg	HNF4A UGT1A4 UGT1A3 ALDH18A1 PKN1	4.70e-07	37	96	5	CID000445227
Drug	Famotidine [76824-35-6]; Up 200; 11.8uM; PC3; HG-U133A	APPBP2 TBRG4 HDAC5 ITPR3 GTF3C1 ANAPC2 MMS19 BBLN	1.75e-06	195	96	8	1946_UP
Disease	xanthurenate measurement	LINGO2 UGT1A4 UGT1A3	1.08e-04	29	94	3	EFO_0010551
Disease	X-11793--oxidized bilirubin measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0021260
Disease	Succinimide measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0022118
Disease	X-11530 measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0021249
Disease	sulfate of piperine metabolite C16H19NO3 (2) measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0801034
Disease	cholelithiasis, bilirubin measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0004570, EFO_0004799
Disease	X-11522 measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0800696
Disease	X-10458 measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0800692
Disease	Hereditary spherocytosis	CAD SPTA1	2.78e-04	8	94	2	C0037889
Disease	X-24849 measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0800909
Disease	membrane-associated progesterone receptor component 1 measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0802740
Disease	X-16946 measurement	UGT1A4 UGT1A3	2.78e-04	8	94	2	EFO_0800766
Disease	spleen volume	MYO9B SPTA1 MAPKAPK5	3.52e-04	43	94	3	EFO_0600047
Disease	X-11442 measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0021236
Disease	X-11441 measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0021235
Disease	circulating cell free DNA measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0004739
Disease	sulfate of piperine metabolite C18H21NO3 (3) measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0801037
Disease	testis-specific chromodomain protein Y 1 measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0802127
Disease	sulfate of piperine metabolite C18H21NO3 (1) measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0801036
Disease	X-11880 measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0800698
Disease	familial melanoma (is_implicated_in)	POT1 MITF	3.56e-04	9	94	2	DOID:6846 (is_implicated_in)
Disease	bilirubin measurement, response to xenobiotic stimulus	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0004570, GO_0009410
Disease	protein-tyrosine kinase 6 measurement	UGT1A4 UGT1A3	3.56e-04	9	94	2	EFO_0020691
Disease	X-21448 measurement	UGT1A4 UGT1A3	4.44e-04	10	94	2	EFO_0800816
Disease	UDP-glucuronosyltransferase 1-6 measurement	UGT1A4 UGT1A3	4.44e-04	10	94	2	EFO_0802185
Disease	X-23974 measurement	UGT1A4 UGT1A3	4.44e-04	10	94	2	EFO_0800867
Disease	bilirubin measurement, response to tenofovir	UGT1A4 UGT1A3	4.44e-04	10	94	2	EFO_0004570, EFO_0009279
Disease	Familial Atypical Mole Melanoma Syndrome	POT1 MITF	5.42e-04	11	94	2	C2314896
Disease	X-21796 measurement	UGT1A4 UGT1A3	5.42e-04	11	94	2	EFO_0800825
Disease	insomnia, bilirubin measurement	UGT1A4 UGT1A3	5.42e-04	11	94	2	EFO_0004570, EFO_0004698
Disease	histidine betaine (hercynine) measurement	UGT1A4 UGT1A3	5.42e-04	11	94	2	EFO_0800972
Disease	aldosterone measurement	UGT1A4 UGT1A3	5.42e-04	11	94	2	EFO_0010219
Disease	biliverdin measurement	UGT1A4 UGT1A3	6.49e-04	12	94	2	EFO_0021033
Disease	p-cresol glucuronide measurement	UGT1A4 UGT1A3	6.49e-04	12	94	2	EFO_0800079
Disease	Papillary Renal Cell Carcinoma	DNHD1 SYNE2 MITF PRAME	7.62e-04	128	94	4	C1306837
Disease	Renal Cell Carcinoma	DNHD1 SYNE2 MITF PRAME	7.62e-04	128	94	4	C0007134
Disease	Sarcomatoid Renal Cell Carcinoma	DNHD1 SYNE2 MITF PRAME	7.62e-04	128	94	4	C1266043
Disease	Chromophobe Renal Cell Carcinoma	DNHD1 SYNE2 MITF PRAME	7.62e-04	128	94	4	C1266042
Disease	Collecting Duct Carcinoma of the Kidney	DNHD1 SYNE2 MITF PRAME	7.62e-04	128	94	4	C1266044
Disease	retinol dehydrogenase 16 measurement	UGT1A4 UGT1A3	7.65e-04	13	94	2	EFO_0802007
Disease	male infertility (implicated_via_orthology)	CFAP47 TCTE1	7.65e-04	13	94	2	DOID:12336 (implicated_via_orthology)
Disease	Left ventricular noncompaction	MIB2 MIB1	8.91e-04	14	94	2	C1960469
Disease	SARS-CoV-2 antibody measurement, response to COVID-19 vaccine	APC2 LINGO2 ANAPC2	1.03e-03	62	94	3	EFO_0803360, EFO_0803362
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	DNHD1 SYNE2 MITF PRAME	1.31e-03	148	94	4	C0279702
Disease	low density lipoprotein cholesterol measurement, body fat percentage	UGT1A4 UGT1A3	1.32e-03	17	94	2	EFO_0004611, EFO_0007800
Disease	angiopoietin-related protein 1 measurement	UGT1A4 UGT1A3	1.49e-03	18	94	2	EFO_0801382
Disease	response to ziprasidone	SOX13 PPP3CA	1.84e-03	20	94	2	GO_0097337
Disease	tissue factor measurement	UGT1A4 UGT1A3	2.03e-03	21	94	2	EFO_0010623
Disease	hormone measurement	UGT1A4 UGT1A3 MYO3B	2.48e-03	84	94	3	EFO_0004730
Disease	cholelithiasis	HNF4A UGT1A4 UGT1A3	2.82e-03	88	94	3	EFO_0004799
Disease	bilirubin measurement	MYO9B SPTA1 ELP6 HNF4A UGT1A4 UGT1A3	2.93e-03	442	94	6	EFO_0004570
Disease	nevus count, cutaneous melanoma	POT1 SYNE2 MITF	3.11e-03	91	94	3	EFO_0000389, EFO_0004632

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLHNEALIRHLNATS	UGT1A3	131	P35503
RNQHLLQHTQDLLRA	EXOC3L4	676	Q17RC7
ALEQFHQLSQVLHRL	ANAPC2	236	Q9UJX6
HQLSQVLHRLSLLER	ANAPC2	241	Q9UJX6
LALNTHLRDLHLDLS	CARMIL2	486	Q6F5E8
ALRSHLHNVDQLLAL	CCDC65	116	Q8IXS2
LHNVDQLLALQRHRL	CCDC65	121	Q8IXS2
LVQQHLDLLHALQER	ARHGEF33	316	A8MVX0
NLLRDLAVHIAHSLR	AARSD1	291	Q9BTE6
LENLCHLHLERNQLR	IGFALS	121	P35858
HLHLERNQLRSLALG	IGFALS	126	P35858
RLLQEAHDLHLSSLQ	APPBP2	401	Q92624
CRHLQENLNSHVLIL	ANKRD36	1636	A6QL64
HLQENLNSHVLILSL	ANKRD36B	1076	Q8N2N9
LLNGLSHQSHLILRA	ELP6	196	Q0PNE2
GLLHISRLLQELHSV	DNHD1	406	Q96M86
EDLASHLLQLRAHLT	DNHD1	3901	Q96M86
HLLQLRAHLTRQLLG	DNHD1	3906	Q96M86
QLRALHLDHNELDAL	AMIGO3	86	Q86WK7
HNVRAAELLLHQEQL	CCDC180	931	Q9P1Z9
HLNHSELAILLNLLQ	CDK13	1086	Q14004
HDLTLVNLHLAALTL	EEPD1	396	Q7L9B9
LRSELNHQHAAAIDL	FAM184A	821	Q8NB25
LALQLSRHNKQLQHL	ITPR3	2056	Q14573
HQNVESHLLNRSLCL	ANAPC1	716	Q9H1A4
HLQENLNSHVLILSL	ANKRD36C	1501	Q5JPF3
HNDHILIENRQLSRL	CT47A1	136	Q5JQC4
HALAHNTNLISLNLR	TCTE1	356	Q5JU00
QIALALRHCHLLNIA	MAPKAPK5	131	Q8IW41
ARAIQLLSQVLLHCH	MMS19	66	Q96T76
STAHLNLISNLLARH	DOP1B	1271	Q9Y3R5
HALTLRNTILFLRHN	FAM91A1	441	Q658Y4
LQADICLHLHRALLQ	KCNH6	576	Q9H252
LSLRTALILHLQHNT	DDX60L	101	Q5H9U9
QVALLRAHAGEHLLL	HNF4A	216	P41235
LAISLSLIAALQAHH	LCN1P1	6	Q5VSP4
SLIAALQAHHLLASD	LCN1P1	11	Q5VSP4
HRALQRLAHLLQADR	PDE6C	81	P51160
SNLLRTLHGLEQEHL	EVC2	496	Q86UK5
LNSLIAHAHRRIDQL	IMMT	401	Q16891
LRQLDQHLDLLKHSN	LAMB2	1311	P55268
RSLISLHLKHLNINN	LINGO2	201	Q7L985
VLHHNFLSLSSLLRN	GLT8D1	21	Q68CQ7
LSQLVHLQELSLLHS	LRRC8E	456	Q6NSJ5
LNHLLLFVNQTLAAH	PDIA2	276	Q13087
ADLVHILTHLQLLRA	IRAK1	81	P51617
LHSLRSLSLHNNLLT	LRRC58	211	Q96CX6
HSNRILHLLTQEALS	ALDH18A1	511	P54886
ALRHHTLSQLRQLQD	MIB1	706	Q86YT6
LLNTPHIQALLLAHD	PALS1	211	Q8N3R9
LTHLEHLSLAHNRLA	LRRC32	96	Q14392
LGAHHQTLQRLVDIL	CA5A	186	P35218
QAARLLNLGRHSLDH	EXOSC10	391	Q01780
LRDHNCLQTLLQHLT	APC2	621	O95996
QDQSLLLTLRHLHSV	C20orf202	51	A1L168
QHSLSLLRAHVALLR	GPAT2	506	Q6NUI2
HLHARLQELLESNRQ	BBLN	51	Q9BUW7
LTNHHSALLILLQDH	FAM172BP	101	A6NC97
QDTTLAHLLQLQLHH	DNAH9	1401	Q9NYC9
HASLLQHVLLLEQAR	HDAC5	441	Q9UQL6
RQSLLHHLCSLVLQT	FHOD1	856	Q9Y613
ARLLAHLLAFESHQQ	CELSR3	2231	Q9NYQ7
ELLFLLGIHRTHNQL	CELSR3	2586	Q9NYQ7
LNLIRGVHLAEHSLQ	SEC22C	201	Q9BRL7
QLHLQHSSLLDFLNA	CFAP47	1626	Q6ZTR5
LHAVSLEQHLLDQIR	PEX1	121	O43933
HNNLLSILRAHEAQD	PPP3CA	271	Q08209
HLAEALHQARLLALL	CHID1	211	Q9BWS9
LIQDAHFHQLLCLLN	TBRG4	121	Q969Z0
LLLLQLQHLAAAAAD	LRP8	21	Q14114
SLVVLHLHNNRIHSL	LGR5	211	O75473
GDTALHVALQRHQLL	MIB2	701	Q96AX9
SANHVAARRLAAHLL	RNF186	146	Q9NXI6
LHSLDRLLLHQNRVA	RTN4R	201	Q9BZR6
VNQRLLLQDLHDSHV	SZT2	1966	Q5T011
LLQDLHDSHVCNSLL	SZT2	1971	Q5T011
LLQHLIGLSNLTHVL	PRAME	426	P78395
NLFHENSDHIILILL	TLR10	716	Q9BXR5
LHRLQALLKHLLSYN	SYNE2	4936	Q8WXH0
IGLHNLLRLHLNSNR	LRRN3	161	Q9H3W5
GLRDLTHLSLANNHI	LGI2	131	Q8N0V4
QLLLVTHLDLSHNRL	RABGGTA	461	Q92696
DLSHIHRLQNLTIDI	POT1	206	Q9NUX5
LQDHILHDLQLRNLS	RNF32	21	Q9H0A6
LHDLQLRNLSVADHS	RNF32	26	Q9H0A6
SRRLDLLHQQLQELH	PKN1	81	Q16512
LLQRHDLLEAQVSAH	SPTBN5	571	Q9NRC6
EFLDQLLLQNIRHHS	NCAPD3	641	P42695
IHQLSTLRDQLLTAH	SOX13	156	Q9UN79
LEHANRHLLLRIQEL	MITF	381	O75030
LLHLHNRSSSELFQD	ROS1	1206	P08922
LLNRHRVILENIASH	SPTA1	831	P02549
GRLSLDDLLQRLHHN	CAD	1721	P27708
LDVLNRHNLLCTIAH	TOPAZ1	1451	Q8N9V7
QQHSILLLLNRFHVD	GTF3C1	236	Q12789
AEQGLLNRHLLAVHS	ZNF711	486	Q9Y462
NLQHLTALVDCRSLH	TTYH3	356	Q9C0H2
HTLARQRLGAALHAL	VWA7	156	Q9Y334
GRSLLHRHLFIQQLL	WWC2-AS2	116	Q96NR7
QALRAQLHQLQLHAA	TCIRG1	116	Q13488
LLHNEALIRHLNATS	UGT1A4	131	P22310
LHTLNLDHNLIDALP	LRFN4	171	Q6PJG9
HLSDALLQNRSLTHL	NLRP13	886	Q86W25
TSLRLLHLEGNLLHQ	MXRA5	151	Q9NR99
LLGLQHLHNNRIIHR	MYO3B	141	Q8WXR4
EANHNSLERLIFHLV	MYO9B	1816	Q13459
SLLHELANLSQSLIH	MYT1L	1116	Q9UL68