Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionintracellularly gated calcium channel activity

TPCN2 RYR1 RYR2

2.72e-0518663GO:0015278
GeneOntologyMolecularFunctionryanodine-sensitive calcium-release channel activity

RYR1 RYR2

6.43e-054662GO:0005219
GeneOntologyMolecularFunctioncullin family protein binding

KCTD6 DCUN1D5 BTBD1

8.49e-0526663GO:0097602
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TPCN2 RYR1 RYR2

1.45e-0431663GO:0099604
GeneOntologyMolecularFunctioncalcium-induced calcium release activity

RYR1 RYR2

1.60e-046662GO:0048763
GeneOntologyMolecularFunctionintracellularly ligand-gated monoatomic ion channel activity

TPCN2 RYR1 RYR2

1.75e-0433663GO:0005217
GeneOntologyMolecularFunctioncalcium ion binding

CAPN8 EFCAB9 MYL1 CAPN1 MACF1 PLCB3 RYR1 RYR2 EHD3

7.65e-04749669GO:0005509
GeneOntologyCellularComponentAP-5 adaptor complex

AP5Z1 AP5M1

6.42e-054692GO:0044599
GeneOntologyCellularComponentjunctional sarcoplasmic reticulum membrane

RYR1 RYR2

4.75e-0410692GO:0014701
GeneOntologyCellularComponentAP-type membrane coat adaptor complex

AP5Z1 AP5M1 AP4B1

5.35e-0448693GO:0030119
HumanPhenoAbnormality of lower limb joint

MYL1 PPP2R5D CAPN1 AFF3 OGDHL MACF1 CYP7B1 UMPS PLCB3 UPF3B AP4B1 GPC6 STAG2 RYR1

2.20e-0510272314HP:0100491
Domain-

CAPN8 EFCAB9 MYL1 CAPN1 MACF1 PLCB3 RYR1 RYR2 EHD3

4.25e-072616891.10.238.10
DomainEF-hand-dom_pair

CAPN8 EFCAB9 MYL1 CAPN1 MACF1 PLCB3 RYR1 RYR2 EHD3

9.39e-07287689IPR011992
DomainEF_hand_dom

CAPN8 EFCAB9 MYL1 CAPN1 MACF1 RYR1 RYR2 EHD3

1.96e-06232688IPR002048
DomainEF_HAND_2

CAPN8 EFCAB9 MYL1 CAPN1 MACF1 RYR2 EHD3

2.06e-05231687PS50222
DomainRyanrecept_TM4-6

RYR1 RYR2

3.91e-053682IPR009460
DomainRyR

RYR1 RYR2

3.91e-053682PF02026
DomainRyanodine_rcpt

RYR1 RYR2

3.91e-053682IPR003032
DomainRR_TM4-6

RYR1 RYR2

3.91e-053682PF06459
DomainRyan_recept

RYR1 RYR2

3.91e-053682IPR013333
DomainRIH_assoc

RYR1 RYR2

1.94e-046682PF08454
DomainRIH_assoc-dom

RYR1 RYR2

1.94e-046682IPR013662
DomainRIH_dom

RYR1 RYR2

1.94e-046682IPR000699
DomainIns145_P3_rcpt

RYR1 RYR2

1.94e-046682IPR014821
DomainRyanodine_recept-rel

RYR1 RYR2

1.94e-046682IPR015925
Domain-

RYR1 RYR2

1.94e-0466821.25.10.30
DomainRYDR_ITPR

RYR1 RYR2

1.94e-046682PF01365
DomainIns145_P3_rec

RYR1 RYR2

1.94e-046682PF08709
DomainARM-type_fold

PPP2R5D UPF2 DOCK8 MROH2A AP4B1 WDFY4 STAG2

2.29e-04339687IPR016024
DomainEF-hand_1

MYL1 CAPN1 MACF1 RYR2 EHD3

2.31e-04152685PF00036
DomainEF-hand_8

CAPN1 RYR1 RYR2

2.55e-0434683PF13833
DomainEFh

CAPN8 MYL1 CAPN1 MACF1 RYR2

2.76e-04158685SM00054
DomainARM-like

DOCK8 AP5Z1 MROH2A AP4B1 WDFY4 STAG2

4.46e-04270686IPR011989
DomainKeratin_I

KRT13 KRT15 KRT27

5.49e-0444683IPR002957
DomainMIR

RYR1 RYR2

5.77e-0410682PS50919
DomainMIR

RYR1 RYR2

5.77e-0410682PF02815
DomainMIR

RYR1 RYR2

5.77e-0410682SM00472
DomainMIR_motif

RYR1 RYR2

5.77e-0410682IPR016093
DomainDOCK_C

DOCK4 DOCK8

7.03e-0411682IPR010703
DomainDHR-1_domain

DOCK4 DOCK8

7.03e-0411682IPR027007
DomainDHR_2

DOCK4 DOCK8

7.03e-0411682PS51651
DomainDHR_1

DOCK4 DOCK8

7.03e-0411682PS51650
DomainDOCK-C2

DOCK4 DOCK8

7.03e-0411682PF14429
DomainDHR-2

DOCK4 DOCK8

7.03e-0411682IPR027357
DomainDHR-2

DOCK4 DOCK8

7.03e-0411682PF06920
DomainDOCK

DOCK4 DOCK8

7.03e-0411682IPR026791
DomainCalpain_III

CAPN8 CAPN1

8.42e-0412682IPR022683
Domaincalpain_III

CAPN8 CAPN1

8.42e-0412682SM00720
DomainC2_III

CAPN8 CAPN1

8.42e-0412682IPR033883
DomainCalpain_domain_III

CAPN8 CAPN1

9.93e-0413682IPR022682
DomainCalpain_III

CAPN8 CAPN1

9.93e-0413682PF01067
DomainCalpain_cysteine_protease

CAPN8 CAPN1

1.16e-0314682IPR022684
DomainCysPc

CAPN8 CAPN1

1.33e-0315682SM00230
DomainPeptidase_C2_calpain_cat

CAPN8 CAPN1

1.33e-0315682IPR001300
DomainPeptidase_C2

CAPN8 CAPN1

1.33e-0315682PF00648
DomainCALPAIN_CAT

CAPN8 CAPN1

1.33e-0315682PS50203
DomainFilament

KRT13 KRT15 KRT27

2.21e-0371683SM01391
DomainIF

KRT13 KRT15 KRT27

2.30e-0372683PS00226
DomainFilament

KRT13 KRT15 KRT27

2.39e-0373683PF00038
DomainIF

KRT13 KRT15 KRT27

2.68e-0376683IPR001664
DomainActinin_actin-bd_CS

SPTBN5 MACF1

3.15e-0323682IPR001589
DomainSpectrin

SPTBN5 MACF1

3.15e-0323682PF00435
DomainACTININ_2

SPTBN5 MACF1

3.15e-0323682PS00020
DomainACTININ_1

SPTBN5 MACF1

3.15e-0323682PS00019
DomainEF_Hand_1_Ca_BS

CAPN8 CAPN1 MACF1 EHD3

3.80e-03175684IPR018247
DomainTHIOL_PROTEASE_CYS

CAPN8 CAPN1

4.01e-0326682PS00139
DomainTHIOL_PROTEASE_ASN

CAPN8 CAPN1

4.32e-0327682PS00640
DomainTHIOL_PROTEASE_HIS

CAPN8 CAPN1

4.32e-0327682PS00639
DomainPept_cys_AS

CAPN8 CAPN1

4.64e-0328682IPR000169
DomainSpectrin_repeat

SPTBN5 MACF1

4.98e-0329682IPR002017
DomainSpectrin/alpha-actinin

SPTBN5 MACF1

6.04e-0332682IPR018159
DomainSPEC

SPTBN5 MACF1

6.04e-0332682SM00150
Pubmed

Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.

CAPN1 RYR1 RYR2

2.60e-07769320962236
Pubmed

The genomic organization of type I keratin genes in mice.

KRT13 KRT15 KRT27

3.34e-061569310087197
Pubmed

Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.

RYR1 RYR2

3.88e-06269217259277
Pubmed

Ryanodine receptor oligomeric interaction: identification of a putative binding region.

RYR1 RYR2

3.88e-06269214722100
Pubmed

Structural and functional interactions within ryanodine receptor.

RYR1 RYR2

3.88e-06269226009179
Pubmed

Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.

RYR1 RYR2

3.88e-06269232899693
Pubmed

Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

RYR1 RYR2

3.88e-06269230542613
Pubmed

Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.

RYR1 RYR2

3.88e-06269215280431
Pubmed

Expression of the ryanodine receptor isoforms in immune cells.

RYR1 RYR2

3.88e-06269211673493
Pubmed

B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.

RYR1 RYR2

3.88e-06269211673462
Pubmed

Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.

RYR1 RYR2

3.88e-06269225370123
Pubmed

Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.

RYR1 RYR2

3.88e-06269215033925
Pubmed

Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.

RYR1 RYR2

3.88e-06269218618700
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ARMT1 ERCC6L GCC2 TBC1D25 MTCL1 LRRC70 STAG2 RYR1 RYR2

4.73e-0663869931182584
Pubmed

Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.

RYR1 RYR2

1.16e-05369218403125
Pubmed

Cutting Edge: Cytosolic Receptor AIM2 Is Induced by Peroxisome Proliferator-activated Receptor γ following Mycobacterium tuberculosis Infection of Human Macrophages but Does Not Contribute to IL-1β Release.

PPARG AIM2

1.16e-05369238251918
Pubmed

Arrangement of a cluster of three mouse type I keratin genes expressed sequentially during esophageal-type epithelial cell differentiation.

KRT13 KRT15

1.16e-0536927535287
Pubmed

Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.

RYR1 RYR2

1.16e-05369218434746
Pubmed

SPRY domains in ryanodine receptors (Ca(2+)-release channels).

RYR1 RYR2

1.16e-0536929204703
Pubmed

The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.

RYR1 RYR2

1.16e-0536927876312
Pubmed

Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.

RYR1 RYR2

1.16e-05369221881589
Pubmed

Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.

RYR1 RYR2

1.16e-05369224123915
Pubmed

The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3.

UPF2 UPF3B

1.16e-05369215004547
Pubmed

Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).

RYR1 RYR2

1.16e-05369212213830
Pubmed

Protein arginine methyltransferase 1 modulates innate immune responses through regulation of peroxisome proliferator-activated receptor γ-dependent macrophage differentiation.

PRMT1 PPARG

1.16e-05369228330868
Pubmed

Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.

RYR1 RYR2

1.16e-05369223278119
Pubmed

Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.

RYR1 RYR2

1.16e-0536929242641
Pubmed

Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.

RYR1 RYR2

1.16e-05369222948152
Pubmed

Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.

RYR1 RYR2

1.16e-05369223454728
Pubmed

Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.

RYR1 RYR2

1.16e-05369210788707
Pubmed

Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.

RYR1 RYR2

1.16e-05369225239916
Pubmed

Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.

RYR1 RYR2

1.16e-0536927621815
Pubmed

Structures of nonsense-mediated mRNA decay factors UPF3B and UPF3A in complex with UPF2 reveal molecular basis for competitive binding and for neurodevelopmental disorder-causing mutation.

UPF2 UPF3B

1.16e-05369235640974
Pubmed

A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.

RYR1 RYR2

1.16e-05369218643873
Pubmed

Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).

RYR1 RYR2

1.16e-05369211159936
Pubmed

PPARγ deacetylation dissociates thiazolidinedione's metabolic benefits from its adverse effects.

BPHL PPARG

1.16e-05369229589839
Pubmed

Intracellular calcium release channel expression during embryogenesis.

RYR1 RYR2

1.16e-0536929986730
Pubmed

Y14 and hUpf3b form an NMD-activating complex.

UPF2 UPF3B

1.16e-05369212718880
Pubmed

Molecular identification of the ryanodine receptor pore-forming segment.

RYR1 RYR2

1.16e-05369210473538
Pubmed

Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.

RYR1 RYR2

1.16e-0536927959768
Pubmed

The organization of proteins in the human red blood cell membrane. A review.

RYR1 RYR2

1.16e-0536924600883
Pubmed

Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.

RYR1 RYR2

1.16e-0536927635066
Pubmed

Proteomic Analysis Reveals a Role for RSK in p120-catenin Phosphorylation and Melanoma Cell-Cell Adhesion.

DOCK4 PPP2R5D MACF1 SRPRA AP4B1

1.72e-0516069531678930
Pubmed

Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.

KCTD6 KRT13 PPP2R5D KRT15 MACF1 PRMT1 SRPRA PLCB3 UPF3B MTCL1 EIF3D STAG2

2.02e-051415691228515276
Pubmed

A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.

RYR1 RYR2

2.32e-05469218206662
Pubmed

Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.

RYR1 RYR2

2.32e-05469222504960
Pubmed

The fifth adaptor protein complex.

AP5Z1 AP5M1

2.32e-05469222022230
Pubmed

A UPF3-mediated regulatory switch that maintains RNA surveillance.

UPF2 UPF3B

2.32e-05469219503078
Pubmed

Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.

RYR1 RYR2

2.32e-05469223992453
Pubmed

Ryanodine receptor calcium release channels: lessons from structure-function studies.

RYR1 RYR2

2.32e-05469223413940
Pubmed

The calpain family and human disease.

CAPN8 CAPN1

2.32e-05469211516996
Pubmed

Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.

RYR1 RYR2

2.32e-0546929384575
Pubmed

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).

UPF2 UPF3B

2.32e-05469211113196
Pubmed

Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.

RYR1 RYR2

2.32e-0546929607712
Pubmed

S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.

RYR1 RYR2

2.32e-05469227226555
Pubmed

Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.

RYR1 RYR2

2.32e-05469219120137
Pubmed

FKBP binding characteristics of cardiac microsomes from diverse vertebrates.

RYR1 RYR2

2.32e-05469211237759
Pubmed

Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.

RYR1 RYR2

2.32e-05469223482488
Pubmed

Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.

RYR1 RYR2

3.86e-05569222939628
Pubmed

Intracellular calcium-release channels: regulators of cell life and death.

RYR1 RYR2

3.86e-0556929124414
Pubmed

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.

RYR1 RYR2

3.86e-05569223918386
Pubmed

Stomach-specific calpain, nCL-2/calpain 8, is active without calpain regulatory subunit and oligomerizes through C2-like domains.

CAPN8 CAPN1

3.86e-05569217646163
Pubmed

The ichq mutant mouse, a model for the human skin disorder harlequin ichthyosis: mapping, keratinocyte culture, and consideration of candidate genes involved in epidermal growth regulation.

CAPN1 PLCB3

3.86e-05569212823437
Pubmed

Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells.

UPF2 UPF3B

3.86e-05569212723973
Pubmed

Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.

UPF2 UPF3B

3.86e-05569211163187
Pubmed

NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.

UPF2 UPF3B

3.86e-05569218369367
Pubmed

Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.

RYR1 RYR2

3.86e-05569219011160
Pubmed

Diversification of stem cell molecular repertoire by alternative splicing.

DOCK8 AIM2 WDFY4

4.67e-053569316183747
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

SPTBN5 MYL1 GCC2 MROH2A AFF3 MACF1 PLCB3

5.79e-0549669731343991
Pubmed

Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.

RYR1 RYR2

5.79e-05669219549818
Pubmed

Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.

RYR1 RYR2

5.79e-05669226025922
Pubmed

Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.

RYR1 RYR2

5.79e-05669223463619
Pubmed

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

UPF2 UPF3B

5.79e-05669222522823
Pubmed

FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.

RYR1 RYR2

5.79e-05669214592808
Pubmed

A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.

RYR1 RYR2

5.79e-05669220519450
Pubmed

Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.

RYR1 RYR2

5.79e-05669225966694
Pubmed

HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.

RYR1 RYR2

5.79e-05669219009018
Pubmed

Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.

UPF2 UPF3B

5.79e-05669212554878
Pubmed

Insights into the recruitment of the NMD machinery from the crystal structure of a core EJC-UPF3b complex.

UPF2 UPF3B

5.79e-05669220479275
Pubmed

IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.

RYR1 RYR2

5.79e-05669216844763
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

ARMT1 MYL1 UPF2 MACF1 BTBD1 STAG2 RYR1

5.86e-0549769723414517
Pubmed

A Single Adaptable Cochaperone-Scaffold Complex Delivers Nascent Iron-Sulfur Clusters to Mammalian Respiratory Chain Complexes I-III.

DOCK4 PLA2R1 DCUN1D5 ERCC6L OGDHL UMPS PRMT1 SRPRA

6.38e-0568669828380382
Pubmed

Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay.

UPF2 UPF3B

8.09e-05769212417715
Pubmed

Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.

RYR1 RYR2

8.09e-05769211860456
Pubmed

Interactions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathways.

UPF2 UPF3B

8.09e-05769218256688
Pubmed

NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.

UPF2 UPF3B

1.08e-04869218066079
Pubmed

The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.

UPF2 UPF3B

1.08e-04869219478851
Pubmed

Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay.

UPF2 UPF3B

1.08e-04869215680326
Pubmed

Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.

RYR1 RYR2

1.08e-04869219033399
Pubmed

The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction.

UPF2 UPF3B

1.08e-0486929933612
Pubmed

Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.

UPF2 UPF3B

1.08e-04869216209946
Pubmed

ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.

TPCN2 RYR1

1.08e-04869230563862
Pubmed

Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.

RYR1 RYR2

1.08e-04869211784029
Pubmed

Functions of hUpf3a and hUpf3b in nonsense-mediated mRNA decay and translation.

UPF2 UPF3B

1.08e-04869216601204
Pubmed

High throughput RNAi screening identifies ID1 as a synthetic sick/lethal gene interacting with the common TP53 mutation R175H.

MEP1A TPCN2 ITGB7

1.29e-044969324378760
Pubmed

eIF4G is required for the pioneer round of translation in mammalian cells.

UPF2 UPF3B

1.38e-04969215361857
Pubmed

The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling.

UPF2 UPF3B

1.38e-04969212093754
Pubmed

Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.

UPF2 UPF3B

1.73e-041069211546874
Pubmed

AAV-mediated intramuscular delivery of myotubularin corrects the myotubular myopathy phenotype in targeted murine muscle and suggests a function in plasma membrane homeostasis.

RYR1 RYR2

1.73e-041069218434328
Pubmed

The RNA helicase Ddx5/p68 binds to hUpf3 and enhances NMD of Ddx17/p72 and Smg5 mRNA.

UPF2 UPF3B

1.73e-041069223788676
Cytoband7p22.2

AP5Z1 GNA12

9.94e-05106927p22.2
CytobandEnsembl 112 genes in cytogenetic band chr11q13

TPCN2 CAPN1 XRRA1 PLCB3 ATG2A

6.18e-04454695chr11q13
Cytoband10q11.23

OGDHL WDFY4

1.14e-033369210q11.23
Cytoband11q22.3

DCUN1D5 EXPH5

2.02e-034469211q22.3
Cytoband2p21

ABCG8 EHD3

3.85e-03616922p21
GeneFamilyEF-hand domain containing

CAPN8 EFCAB9 MYL1 CAPN1 MACF1 RYR2 EHD3

3.85e-07219397863
GeneFamilyRyanodine receptors|Protein phosphatase 1 regulatory subunits

RYR1 RYR2

1.36e-053392287
GeneFamilyKeratins, type I

KRT13 KRT15 KRT27

2.93e-0528393608
GeneFamilyC2 domain containing|Calpains

CAPN8 CAPN1

4.68e-0415392975
GeneFamilyBasic leucine zipper proteins|BTB domain containing

KLHL25 BTBD1

3.38e-02134392861
ToppCellCOPD-Lymphoid-B|COPD / Disease state, Lineage and Cell class

UPF2 AFF3 SIDT1 AIM2 WDFY4 EHD3

4.31e-07185696925e79c35c381dd44ec5fb921dca09ce43140135
ToppCellCOPD-Lymphoid-B|World / Disease state, Lineage and Cell class

UPF2 AFF3 SIDT1 AIM2 WDFY4 EHD3

4.31e-0718569622891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

UPF2 PRMT1 AIM2 WDFY4 ITGB7 EHD3

5.52e-071936969f798a1bbd9f076c3122d02ed28418c18bb7a369
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ERCC6L AP5Z1 AFF3 AIM2 WDFY4 ITGB7

6.04e-07196696f37ffb916480281e5905733ac304102dd2e0c05f
ToppCellTracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_mature|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ERCC6L AP5Z1 AFF3 AIM2 WDFY4 ITGB7

6.04e-071966964b9eb163b9dbbf5eebb160f6554f6f28cb234d31
ToppCellfacs-Heart-Unknown-3m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6L KRT27 MROH2A PNMA2 OGDHL

2.69e-061416954aa4b3476dc5abefbd348353cfe711cd5fe3d52f
ToppCellfacs-Heart-Unknown-3m-Endothelial-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6L KRT27 MROH2A PNMA2 OGDHL

2.69e-06141695e40c6f1b7fbaa46b3eaa55f1b37ef360b04370a8
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT13 TPCN2 KRT15 DOCK8 ITGB7

5.47e-061636958028636632c168dc50731d0ebecaf88a70daf81d
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

UPF2 AFF3 PNMA2 AIM2 WDFY4

5.98e-061666958de8f388f24436b84e19ef460476fdbda4d16abf
ToppCellfacs-Kidney-nan-24m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF3 AIM2 WDFY4 ITGB7 RYR1

6.15e-061676953c4183a8225bae37b9f5341ebd1b95409ced2022
ToppCellfacs-Kidney-nan-24m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF3 AIM2 WDFY4 ITGB7 RYR1

6.15e-0616769528e9670586ff551b700c794313d27eedbfa1286b
ToppCellPND14-Immune-Immune_Myeloid-Dendritic|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERCC6L SIDT1 CLSPN WDFY4 ICA1L

6.34e-061686959b8a74abb83c64f0b5829dcb4275f722c82b45dc
ToppCellPND14-Immune-Immune_Myeloid-Dendritic-cDC1|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERCC6L SIDT1 CLSPN WDFY4 ICA1L

6.34e-061686954b152b8d0f4a66faf664dfacb7914b18d60ce64a
ToppCellPND14-Immune-Immune_Myeloid-Dendritic-cDC1-cDC1_G2M|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ERCC6L SIDT1 CLSPN WDFY4 ICA1L

6.34e-06168695c3169ad8f4130ef18777ed86770bb722ffb5db85
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT15 KRT27 MROH2A DNAH17

8.09e-068269473349906bcc8d1a40dc03df7a490a963e85564f2
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))--|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT15 KRT27 MROH2A DNAH17

8.09e-068269415bc417aaace2b1d680904a622fe76e95083c9ff
ToppCellGlobus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Trh_(Substantia_Innominata_(SI))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

KRT15 KRT27 MROH2A DNAH17

8.09e-0682694697e1da3095c8483b8181b290fa5417bdc9cee54
ToppCell3'-Pediatric_IBD-SmallIntestine-Hematopoietic-B_cells-FCRL4+_Memory_B|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EFCAB9 AIM2 WDFY4 ITGB7 EHD3

8.85e-06180695eedb6d89680f968167afb1dcd132c9de9096b50f
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

RABGAP1L AFF3 SIDT1 AIM2 WDFY4

9.10e-061816958d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCelldroplet-Marrow-nan-3m-Myeloid-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 GCC2 MACF1 STAG2 GFRA1

9.34e-06182695f8c73baaaca145e2efc48f10f636feb79c8fc779
ToppCelldroplet-Marrow-nan-3m-Hematologic-nan|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GCC2 SIDT1 MACF1 STAG2 EHD3

9.34e-06182695e78ba2c5cae480c16a596ce7c3bf2d480becacf4
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KRT13 KRT15 SIDT1 MTCL1 PPARG

9.34e-06182695678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCelldroplet-Marrow-nan-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GCC2 SIDT1 MACF1 STAG2 EHD3

9.34e-061826951710eab3037a87609d21838be2d2d29c3bc36651
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KRT13 KRT15 SIDT1 MTCL1 PPARG

9.34e-061826958d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 AFF3 SIDT1 AIM2 WDFY4

9.85e-06184695f81209e6bc01a0140f4487aa8b22eb02fbf0c39c
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 GCC2 MACF1 STAG2 GFRA1

1.01e-051856957adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellfacs-Brain_Non-Myeloid-Cerebellum|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CDR1 EXPH5 MTCL1 WDFY4 RYR2

1.01e-05185695c083a4974590b9ed3ecafedd3e9cdebc5047fe39
ToppCellCOVID-19-lung-B_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

DOCK8 AFF3 SIDT1 AIM2 WDFY4

1.01e-05185695e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 SIDT1 GNA12 AIM2 WDFY4

1.06e-051876958fa454dc4e6a3e8e2bb2ad803acc579e0d3f76da
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Immune-Lymphocytic_B-B_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 SIDT1 GNA12 AIM2 WDFY4

1.06e-05187695edad646d5eb1d70b768dc21fe02ef5265214e8e6
ToppCellfacs-Skin-Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39C CAPN1 BTBD1 GPC6 GFRA1

1.12e-05189695adbfc723130079b4caf551f66d2aee86fab1903c
ToppCellfacs-Skin-Anagen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39C CAPN1 BTBD1 GPC6 GFRA1

1.15e-05190695888ded899f0513d41bf655896d59ae8ef74e0978
ToppCellBLOOD--(3)_MNP-(3)_DC_(cDC+pDC)|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

AFF3 SIDT1 PRMT1 WDFY4 ITGB7

1.15e-051906959b8de47f7a2e6137d934ccce32417ab15eb54f46
ToppCellfacs-Skin-Anagen-3m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39C CAPN1 BTBD1 GPC6 GFRA1

1.15e-051906953466cebab16964e94da130d0673fa32e7d90b5ed
ToppCellCOPD-Lymphoid-B|Lymphoid / Disease state, Lineage and Cell class

UPF2 AFF3 GNA12 WDFY4 EHD3

1.15e-051906951e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK4 MACF1 CYP7B1 GPC6 RYR2

1.24e-0519369599525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCellChildren_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

DOCK4 MACF1 CYP7B1 GPC6 RYR2

1.24e-05193695b3ad5ff480d99217f36cc7471e5a96a519ddb409
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CAPN8 KRT13 KRT15 SIDT1 PPARG

1.24e-05193695a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCellCF-Lymphoid|CF / Disease state, Lineage and Cell class

TTC39C AFF3 SIDT1 PRMT1 WDFY4

1.24e-0519369511de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCellsevere_COVID-19-B_intermediate|World / disease group, cell group and cell class (v2)

UPF2 AFF3 SIDT1 AIM2 WDFY4

1.27e-05194695cb346cb186fe80a8f490ae90b2539b3543ba0ca9
ToppCellsevere_COVID-19-B_intermediate|severe_COVID-19 / disease group, cell group and cell class (v2)

UPF2 AFF3 SIDT1 AIM2 WDFY4

1.37e-051976953ba64850b344cb24a4d20d64392a0b2752950d40
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial|GW12 / Sample Type, Dataset, Time_group, and Cell type.

PLA2R1 DOCK8 SIDT1 CYP7B1 RYR1

1.47e-05200695be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCell3'_v3-blood-Lymphocytic_T_CD4-T_CD4/CD8|blood / Manually curated celltypes from each tissue

CAPN8 MACF1 ATG2A ABCG8

5.76e-05135694ae2d3a42e567b5bade304c0caa497eb725be3565
ToppCellfacs-Heart-Unknown-3m-Endothelial|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ERCC6L KRT27 MROH2A PNMA2

7.01e-05142694759fbbd15b4fb313bd6269b7f087edafebd530ef
ToppCellTCGA-Breast|World / Sample_Type by Project: Shred V9

ARMT1 AFF3 SIDT1 GFRA1

8.67e-0515069408686ba1acac5c58667bf62e2af84c691d6bbdfb
ToppCellfacs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CAPN1 PPARG ITGB7 RYR1

1.01e-041566942ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCell368C-Myeloid-Dendritic-cDC1|368C / Donor, Lineage, Cell class and subclass (all cells)

CDR1 AIM2 WDFY4 ITGB7

1.06e-04158694c276a259e20ee704e2d04baf693e8d677f96f654
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

DOCK8 PPARG AIM2 WDFY4

1.09e-041596940c2437da5443fc3aff66f8ef311f02aa434a1fb0
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

UPF2 AFF3 PNMA2 WDFY4

1.11e-041606946722934e153b72039c3c4308557d0ef879a30638
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

MREG AFF3 AIM2 WDFY4

1.14e-0416169463f0b97c741b610c450f65fa5764d712bfe09ce8
ToppCell368C-Myeloid-Dendritic-cDC1|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KLHL25 AIM2 WDFY4 ITGB7

1.14e-041616941011094c54381d52566e24c92f89f2efc2aa3eea
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEP1A CAPN8 TTC39C CYP7B1

1.17e-041626946972d45f4bd4b6522bf93295f7e9dca7c6cba1f3
ToppCell368C-Myeloid-Dendritic-cDC1|Dendritic / Donor, Lineage, Cell class and subclass (all cells)

KLHL25 AIM2 WDFY4 ITGB7

1.19e-04163694299ac2463b7f58eee419d822a2a2d64b973d87e9
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-basal_bladder_epithelial_cell_(Krt5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MREG KRT15 MROH2A SIDT1

1.25e-04165694936581de8fcd097401707438b9bbe89dd4e3e247
ToppCelldroplet-Lung-nan-3m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT13 UMPS WDFY4 RYR1

1.31e-04167694f33cef917fa733adf6d5a9a9e989a4d9fd462a8f
ToppCellControl-B_cells-Activated_B_cells|Control / group, cell type (main and fine annotations)

DOCK8 AFF3 AIM2 WDFY4

1.34e-04168694a7159a35fe37f8c241cf8d391debe271e0698105
ToppCelldroplet-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT13 WDFY4 ITGB7 RYR1

1.34e-04168694d6078e3a79d315d6090906e171a7d67a9206b2c7
ToppCelldroplet-Kidney-KIDNEY-1m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEP1A CAPN8 TTC39C CYP7B1

1.34e-0416869435ce3b2b9c9997d4c101da5949c7271d6a6b8f12
ToppCelldroplet-Lung-nan-18m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MREG ERCC6L CLSPN WDFY4

1.34e-0416869496f7411474edd673b8d3ee6b8a8bb185c246daaf
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_prolif|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CAPN1 PPARG AIM2 WDFY4

1.37e-04169694305cedbd97059029d7d2a248a8a4b6cfe281aa54
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYL1 KRT15 ABCG8 GFRA1

1.37e-0416969408ac28c5ad8f5c5f9f54af341bf39e8f9417636e
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CAPN8 EFCAB9 EXPH5 AFF3

1.37e-04169694225aec04ba762d4c55885257de03a65b63503fbb
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

CAPN8 EFCAB9 EXPH5 AFF3

1.37e-04169694278960f940b646a788360b1c84d641a8d169896b
ToppCellE16.5-Epithelial-Epithelial_Airway-Neurosecretory-Secretory|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MYL1 KRT15 ABCG8 GFRA1

1.37e-04169694e5abd41db1e6724ad900e37658fa063b8e522908
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 SIDT1 AIM2 WDFY4

1.40e-04170694a965e3ee6818790a4a6916824fde64333d9b11b7
ToppCelldroplet-Lung-nan-21m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT13 WDFY4 ITGB7 RYR1

1.40e-0417069471c52fadecc6b4bfe98692b266adaa1406f6d56d
ToppCellChildren_(3_yrs)-Immune-B_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFF3 SIDT1 AIM2 WDFY4

1.40e-04170694e421f9eedf74baffda1d03707a710ece4b777f29
ToppCellCOVID-19-kidney-Bcells|COVID-19 / Disease (COVID-19 only), tissue and cell type

AFF3 SIDT1 AIM2 WDFY4

1.44e-041716948e8fb79968b1a5c34d1d9cad7f9155fabfdb7cc7
ToppCellcellseq2-Epithelial-Epithelial_Airway-Basal/Suprabasal-Basal|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

KRT13 KRT15 OGDHL RYR1

1.47e-04172694e9095c3dac66cf93d31f5f88364b565abacb1e2d
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39C RABGAP1L ICA1L ITGB7

1.47e-041726944d04df9776394ea156ed5822f92ae74fdefbaa3d
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TTC39C RABGAP1L ICA1L ITGB7

1.47e-041726943acf35b774ebc0f9e96299d0bd3e9d03bbf6b90c
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT13 WDFY4 ITGB7 RYR1

1.50e-04173694f66aebceb3eb389bc5ff6c0b398d6f4e9959a14f
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 AIM2 WDFY4 EHD3

1.57e-041756941b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCellIIF-Lymphocyte-B-B_intermediate|IIF / Disease, Lineage and Cell Type

AFF3 MTCL1 AIM2 WDFY4

1.57e-04175694327f8ee3669c3fc5ba50abc3b4f3e068637fd8d8
ToppCellCOVID-mDC1-|COVID / Condition, Cell_class and T cell subcluster

SPTBN5 EFCAB9 AIM2 WDFY4

1.57e-0417569483a95d6fc2ddf3ec53f05825bbc982fb8d2ccd15
ToppCellCOVID-mDC1|COVID / Condition, Cell_class and T cell subcluster

SPTBN5 EFCAB9 AIM2 WDFY4

1.57e-04175694b9280444016e21c28131a61df65cc5c56d402412
ToppCelldroplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KRT13 WDFY4 ITGB7 RYR1

1.60e-041766947b5e50eb144bf43ca0cf354a466eb58b976a79f1
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 AFF3 AIM2 WDFY4

1.60e-04176694274458d80f9f3f080248cbf64e4784ef351e7254
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_GPR21|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SPTBN5 MREG EXPH5 GFRA1

1.60e-04176694ed7ba2a3af3b060dec98b60f09f96000a67f7e63
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

DOCK8 AFF3 AIM2 WDFY4

1.60e-04176694d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell5'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK8 TTC39C AFF3 ITGB7

1.60e-04176694238244294d08975df6bfa26b2b437db3654408ae
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

DOCK8 AFF3 AIM2 WDFY4

1.60e-04176694d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCellCOVID-19-Myeloid-MoAM4|COVID-19 / Condition, Lineage and Cell class

MEP1A KCTD6 CYP7B1 RYR1

1.64e-04177694ca5d0c3d5c700bbe4c2da068eb02be6229afb9a0
ToppCellCOVID-19-lung-B_cells|lung / Disease (COVID-19 only), tissue and cell type

AFF3 SIDT1 AIM2 WDFY4

1.64e-04177694f54691e5558091c1734ab15153a10bff15ed171e
ToppCellfacs-Lung-EPCAM-18m-Myeloid-myeloid_dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 WDFY4 ITGB7 RYR1

1.64e-041776947bc92314b22a876296a4e2db51e7fb0fdfd69379
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 SIDT1 AIM2 WDFY4

1.64e-04177694b07e6139618d888a9fd7cf43cad0d86a3f63e09e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

AFF3 GNA12 WDFY4 EHD3

1.64e-0417769437d1abe1a9d8f2b8f4d146bbf1db94104eab6593
ToppCellCOVID-19-B_cells-Activated_B_cells|COVID-19 / group, cell type (main and fine annotations)

RABGAP1L AFF3 AIM2 WDFY4

1.64e-04177694653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-B_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

AFF3 SIDT1 AIM2 WDFY4

1.64e-041776946376ec12322c04d5d37ec2fdc376700464cbc7fb
ToppCellfacs-Lung-EPCAM-18m-Myeloid-Myeloid_Dendritic_Type_2|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DOCK8 WDFY4 ITGB7 RYR1

1.64e-041776943cb96d7d56c9ff90f1f8a6caaf49e580e2524c7d
ToppCellPBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-0|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

AFF3 AIM2 WDFY4 EHD3

1.68e-04178694be1d991c5a0a5be22f14f57d34ee1330f1a12963
ToppCelldroplet-Marrow-nan-3m-Hematologic-hematopoietic_precursor_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFF3 SIDT1 MACF1 EHD3

1.68e-041786948aef208b6351143562c87715bb11628880abce94
ToppCell3'-GW_trimst-1-SmallIntestine-Hematopoietic-Myeloid-pDC|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK8 SIDT1 WDFY4 ITGB7

1.68e-04178694b7d1d8f76c1c2467b1a39a9b4150ed4a47144a15
ToppCellfacs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK8 WDFY4 ITGB7 RYR1

1.71e-0417969433ed9270d257895ff3b40df2c1af878119c9f492
ToppCell3'-GW_trimst-1.5-LargeIntestine-Hematopoietic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DOCK8 SIDT1 WDFY4 RYR1

1.71e-04179694716856b2c7c660bf5ce00e63efeda6ed121f2baa
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-T_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT13 RBM12B ATG2A ITGB7

1.71e-0417969430efe1f0394c0edb27b91890b5c4637b73cbc5ec
ToppCellfacs-Lung-18m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DOCK8 WDFY4 ITGB7 RYR1

1.71e-04179694b7a2429d07d7146b32b3552a5f2a2542105a71e0
ToppCellnormal_Lung-B_lymphocytes|normal_Lung / Location, Cell class and cell subclass

AFF3 SIDT1 AIM2 WDFY4

1.71e-041796945b89193486100b6754c1c5eca3105ea955805eae
ToppCellIPF-Lymphoid-B|World / Disease state, Lineage and Cell class

AFF3 SIDT1 AIM2 WDFY4

1.75e-0418069430f9398c9b784f49470847a025bac90687e997a1
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_B-B_plasma-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

SPTBN5 PNMA2 MTCL1 RYR2

1.75e-041806948e96f8646c002768b272359af485dc0ab57e0ccd
DrugProguanil hydrochloride [637-32-1]; Down 200; 13.8uM; HL60; HT_HG-U133A

MREG RABGAP1L DNAH17 GNA12 ITGB7 RYR2 EHD3

2.16e-061966972944_DN
DrugR 478

PPARG RYR1 RYR2

4.32e-0611693CID000084223
Drug2-hydroxycarbazole

RYR1 RYR2

2.71e-053692CID000093551
Drugcis-diammineplatinum(II

RYR1 RYR2

2.71e-053692CID000159790
Drug2-hydroxyheptanoic acid

RYR1 RYR2

2.71e-053692CID002750949
DrugRyanodyl 3-(pyridine-3-carboxylate

RYR1 RYR2

2.71e-053692CID005748312
Drug8N3-cADPR

RYR1 RYR2

2.71e-053692CID000127713
Drugaminodantrolene

RYR1 RYR2

2.71e-053692CID009570289
DrugPCB74

RYR1 RYR2

5.41e-054692CID000036218
Drug148504-47-6

RYR1 RYR2

5.41e-054692CID006444275
DrugSC 38249

RYR1 RYR2

5.41e-054692CID000134834
DrugAC1L1U7A

RYR1 RYR2

5.41e-054692CID000035682
Diseasecongenital myopathy 1A (implicated_via_orthology)

RYR1 RYR2

1.43e-053652DOID:3529 (implicated_via_orthology)
Diseasemalignant hyperthermia (implicated_via_orthology)

RYR1 RYR2

1.43e-053652DOID:8545 (implicated_via_orthology)
Diseasehereditary spastic paraplegia 76 (implicated_via_orthology)

CAPN8 CAPN1

4.76e-055652DOID:0110821 (implicated_via_orthology)
DiseaseCongenital myopathy (disorder)

MYL1 RYR1

3.11e-0412652C0270960
Diseasemean platelet volume

KCTD6 DOCK8 GCC2 AFF3 SIDT1 UMPS ICA1L ABCG8 EHD3

3.83e-041020659EFO_0004584
Diseaseeating disorder, bipolar disorder

AIM2 RYR2

4.27e-0414652EFO_0005203, MONDO_0004985
DiseaseIntellectual Disability

PPP2R5D DOCK8 AFF3 MACF1 UMPS STAG2

4.54e-04447656C3714756
Diseaseserum IgG measurement

KCTD6 AFF3

7.15e-0418652EFO_0004565
Diseaseresponse to methotrexate, neurotoxicity

MACF1 GPC6

7.98e-0419652EFO_0011057, GO_0031427
Diseaseperipheral arterial disease, traffic air pollution measurement

AP5Z1 MACF1 MTCL1 NSMCE1

8.97e-04194654EFO_0004265, EFO_0007908
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

MACF1 PLCB3 PPARG ABCG8

1.47e-03222654EFO_0008317, EFO_0020943
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

MACF1 PLCB3 PPARG ABCG8

1.55e-03225654EFO_0008317, EFO_0020947
DiseaseChild Development Disorders, Specific

DOCK8 WDFY4

1.87e-0329652C0085997
DiseaseChild Development Deviations

DOCK8 WDFY4

1.87e-0329652C0085996
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

MACF1 PLCB3 PPARG ABCG8

1.93e-03239654EFO_0008317, EFO_0020945
DiseaseDevelopmental Disabilities

DOCK8 WDFY4

2.00e-0330652C0008073

Protein segments in the cluster

PeptideGeneStartEntry
LAKENREFFNDLDLL

AFF3

1181

P51826
DLDENQLKDEFFKLL

ARMT1

171

Q9H993
ELDRFKFFLSDEFNI

AIM2

21

O14862
EELFDILNLLDSFLK

AP4B1

231

Q9Y6B7
AALFLEKVRDLDDFL

ABCG8

346

Q9H221
DQKFVLALLDLFDSE

PPP2R5D

236

Q14738
QINKFFEALEALLFE

AP5Z1

666

O43299
DQEDDQFRRLFEKLA

CAPN8

531

A6NHC0
EEIDENFKALFRQLA

CAPN1

541

P07384
FLEAIDLREDKDFLE

CDR1

111

P51861
FDFARDKDQRSLDID

DCUN1D5

146

Q9BTE7
RLNVDQDALFFLKDF

ATG2A

1586

Q2TAZ0
AKNNRDLDFTIDLDF

PRMT1

341

Q99873
VQKFFADFLLAEDDI

RBM12B

416

Q8IXT5
AFKALLEDFRAELRE

MTCL1

1141

Q9Y4B5
AADDFRLKYENELAL

KRT13

186

P13646
LKDLFRDFDITGDNR

EFCAB9

141

A8MZ26
FYDLQEADLDKEFQL

OGDHL

161

Q9ULD0
ARLTADDFRLKFENE

KRT27

166

Q7Z3Y8
DDFRLKFENELALHQ

KRT27

171

Q7Z3Y8
LDRLEELKEFANFDF

MACF1

3141

O94854
NEFFQVLDDLDSKLA

EXPH5

206

Q8NEV8
LAADDFRLKYENELA

KRT15

186

P19012
QQDEFKEAFLLFDRT

MYL1

51

P05976
LFELRLLDDDKDFVE

AP5M1

56

Q9H0R1
EFLERLNLFLEKEGQ

PNMA2

101

Q9UL42
VEKLNEAFDILLAFF

LRRC70

521

Q7Z2Q7
NDALDRLEELKEFAN

MACF1

7011

Q9UPN3
RLEELKEFANFDFDV

MACF1

7016

Q9UPN3
EDLLQADFEGALKFF

RABGAP1L

741

Q5R372
RTLDNQLFFFLVEDD

ITGB7

691

P26010
DEFSLEIFERFLNKL

PLCB3

206

Q01970
FKNQEDIILFRDRFD

UPF3B

101

Q9BZI7
DEFFRELLENAEKSL

GPC6

106

Q9Y625
DVRDAAAEFLEKNLF

KLHL25

131

Q9H0H3
LSDALRKNFLNENFD

DOCK4

986

Q8N1I0
FFKQEGDRLSDEDLF

DOCK8

471

Q8NF50
LDEFDQFIRKSLSFL

DNAH17

871

Q9UFH2
DLEECLKFLNFFKDN

GFRA1

321

P56159
KERFAFLFNSELLSD

BTBD1

56

Q9H0C5
LFFDKRDNSDFDLLT

EIF3D

276

O15371
ENLELDEFLFLEQAA

CENPJ

571

Q9HC77
FFHEREDLEFKINEL

GCC2

376

Q8IWJ2
DQKALLEFRDTIFDN

GNA12

86

Q03113
LDFKEFDLLRKEADF

KCTD6

81

Q8NC69
NKFISELRDDFLKFD

CYP7B1

206

O75881
EDFEKEFSFLNNLLS

ICA1L

341

Q8NDH6
LRFADEFNKLAEDFL

BPHL

276

Q86WA6
LEEDSALEALLNFFF

FMR1NB

116

Q8N0W7
DDEFTQDLFRFLQLL

RYR1

3876

P21817
ALRAFLDNAAEDLEK

RYR2

3056

Q92736
FAENELDLFRKALEL

NSMCE1

101

Q8WV22
DLEEAFKLFNLAKDI

ERCC6L

36

Q2NKX8
DEDARNFYENLIDLK

UPF2

461

Q9HAU5
DNESELLRLKAFILF

MROH2A

1481

A6NES4
NLIILLEDEVFADFF

RGSL1

11

A5PLK6
LLELKREFAFDDALR

TBC1D25

411

Q3MII6
DRLIALDAAEEFFKL

MREG

171

Q8N565
KFNALELDDSDLAIF

PPARG

401

P37231
FLKNDDLIIFVDFED

MEP1A

581

Q16819
DNRKLFEAEEQDLFR

EHD3

266

Q9NZN3
KDEAENAFLLEELFA

PLA2R1

1291

Q13018
ARSLLLKFFRDADEE

SPTBN5

2891

Q9NRC6
RQALFKLDNEDGFEE

CLSPN

616

Q9HAW4
LADKFNRLLEDFLQE

STAG2

661

Q8N3U4
REKNRECILLDFFDD

SIDT1

776

Q9NXL6
FFRRNGLFEKLAEDL

WDFY4

701

Q6ZS81
EFLIFEDRKFADIGN

UMPS

306

P11172
FDFQNDFLRLLREAE

SRPRA

111

P08240
LLFDDEQFVVKAFRL

ELAC1

166

Q9H777
ELNFKDAFDSFERLK

TTC39C

366

Q8N584
DFKLLEFLDLSFNSL

XRRA1

161

Q6P2D8
LSAEEFQKLFNELDR

TPCN2

391

Q8NHX9