Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionendothelin B receptor binding

EDN1 EDN2

4.86e-053812GO:0031708
GeneOntologyMolecularFunctionbombesin receptor binding

EDN1 EDN2

9.70e-054812GO:0031705
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

TGFBR1 INSRR MUSK PTK7

3.96e-0485814GO:0019199
GeneOntologyBiologicalProcessregulation of prostaglandin-endoperoxide synthase activity

EDN1 EDN2

4.23e-053782GO:0060584
GeneOntologyBiologicalProcesspositive regulation of prostaglandin-endoperoxide synthase activity

EDN1 EDN2

4.23e-053782GO:0060585
GeneOntologyBiologicalProcessregulation of mitotic cell cycle

ANGEL2 GTSE1 FBXW5 PIDD1 TM4SF5 AKT1 STOX1 EME2 CDC14B EDN1

7.87e-055947810GO:0007346
GeneOntologyBiologicalProcessnegative regulation of long-chain fatty acid import across plasma membrane

AKT1 AKT2

8.43e-054782GO:0010748
GeneOntologyBiologicalProcessnegative regulation of long-chain fatty acid import into cell

AKT1 AKT2

8.43e-054782GO:0140213
GeneOntologyBiologicalProcessmonocarboxylic acid metabolic process

NPC1 ECHDC3 ACADSB HAGHL ABHD10 AKT1 AKT2 ECI2 ALDOC EDN1 EDN2

9.20e-057317811GO:0032787
GeneOntologyBiologicalProcessvein smooth muscle contraction

EDN1 EDN2

1.40e-045782GO:0014826
GeneOntologyBiologicalProcessregulation of cell cycle phase transition

TELO2 GTSE1 PIDD1 TM4SF5 AKT1 STOX1 EME2 CDC14B MOS

1.41e-04516789GO:1901987
GeneOntologyBiologicalProcessDNA damage checkpoint signaling

TELO2 GTSE1 PIDD1 EME2 CDC14B

1.66e-04136785GO:0000077
GeneOntologyBiologicalProcessregulation of systemic arterial blood pressure by endothelin

EDN1 EDN2

2.10e-046782GO:0003100
GeneOntologyBiologicalProcessDNA integrity checkpoint signaling

TELO2 GTSE1 PIDD1 EME2 CDC14B

2.24e-04145785GO:0031570
GeneOntologyBiologicalProcessregulation of cell cycle

TGFBR1 TELO2 ANGEL2 GTSE1 FBXW5 PIDD1 TM4SF5 AKT1 AKT2 STOX1 EME2 CDC14B EDN1 MOS

2.34e-0412567814GO:0051726
GeneOntologyBiologicalProcessregulation of long-chain fatty acid import across plasma membrane

AKT1 AKT2

2.93e-047782GO:0010746
GeneOntologyBiologicalProcessregulation of cell cycle process

TELO2 GTSE1 FBXW5 PIDD1 TM4SF5 AKT1 STOX1 EME2 CDC14B EDN1 MOS

3.24e-048457811GO:0010564
GeneOntologyBiologicalProcesspositive regulation of smooth muscle contraction

TBXA2R EDN1 EDN2

3.40e-0436783GO:0045987
GeneOntologyBiologicalProcessmitotic DNA damage checkpoint signaling

GTSE1 PIDD1 EME2 CDC14B

3.94e-0491784GO:0044773
GeneOntologyBiologicalProcessmitotic DNA integrity checkpoint signaling

GTSE1 PIDD1 EME2 CDC14B

4.64e-0495784GO:0044774
GeneOntologyBiologicalProcesscarboxylic acid metabolic process

NPC1 ECHDC3 ACADSB HAGHL ABHD10 AKT1 AKT2 ECI2 ALDOC EDN1 EDN2 ABCC10

4.86e-0410357812GO:0019752
GeneOntologyBiologicalProcessperipheral nervous system myelin maintenance

AKT1 AKT2

5.00e-049782GO:0032287
GeneOntologyBiologicalProcessregulation of long-chain fatty acid import into cell

AKT1 AKT2

5.00e-049782GO:0140212
GeneOntologyBiologicalProcessregulation of nitric oxide biosynthetic process

EPOR AKT1 AKT2 EDN1

5.02e-0497784GO:0045428
GeneOntologyBiologicalProcessregulation of vasoconstriction

TBXA2R AKT1 EDN1 EDN2

5.22e-0498784GO:0019229
GeneOntologyBiologicalProcessregulation of fatty acid transport

AKT1 AKT2 EDN1

5.37e-0442783GO:2000191
GeneOntologyBiologicalProcessregulation of nitric oxide metabolic process

EPOR AKT1 AKT2 EDN1

5.64e-04100784GO:0080164
GeneOntologyBiologicalProcesscellular response to insulin stimulus

ECHDC3 INSRR AKT1 AKT2 VWA2 STAT1

5.67e-04271786GO:0032869
GeneOntologyBiologicalProcessglucan metabolic process

NPC1 GYS1 AKT1 AKT2

5.85e-04101784GO:0044042
GeneOntologyBiologicalProcesscell cycle phase transition

TELO2 GTSE1 PIDD1 TM4SF5 AKT1 STOX1 EME2 CDC14B MOS

5.89e-04627789GO:0044770
GeneOntologyBiologicalProcessoxoacid metabolic process

NPC1 ECHDC3 ACADSB HAGHL ABHD10 AKT1 AKT2 ECI2 ALDOC EDN1 EDN2 ABCC10

5.90e-0410587812GO:0043436
GeneOntologyBiologicalProcesscellular response to peptide hormone stimulus

ECHDC3 INSRR AKT1 AKT2 VWA2 EDN1 STAT1

5.95e-04381787GO:0071375
GeneOntologyBiologicalProcessorganic acid metabolic process

NPC1 ECHDC3 ACADSB HAGHL ABHD10 AKT1 AKT2 ECI2 ALDOC EDN1 EDN2 ABCC10

6.21e-0410647812GO:0006082
DomainBibrotoxin/Sarafotoxin-D

EDN1 EDN2

5.29e-053792IPR020475
DomainEndothelin

EDN1 EDN2

5.29e-053792PF00322
DomainEndothln-like_toxin

EDN1 EDN2

5.29e-053792IPR001928
DomainEndothelin_toxin_CS

EDN1 EDN2

5.29e-053792IPR019764
DomainENDOTHELIN

EDN1 EDN2

5.29e-053792PS00270
DomainEND

EDN1 EDN2

5.29e-053792SM00272
DomainIGc2

LRIG2 LRIT2 LRRN3 VSIG10L DCC MUSK PTK7

6.13e-05235797SM00408
DomainIg_sub2

LRIG2 LRIT2 LRRN3 VSIG10L DCC MUSK PTK7

6.13e-05235797IPR003598
DomainIG

LRIG2 LRIT2 LRRN3 OSCAR VSIG10L ILDR1 DCC MUSK PTK7

7.04e-05421799SM00409
DomainIg_sub

LRIG2 LRIT2 LRRN3 OSCAR VSIG10L ILDR1 DCC MUSK PTK7

7.04e-05421799IPR003599
Domain-

LRIG2 EPOR LRIT2 LRRN3 INSRR OSCAR VSIG10L ILDR1 DCC MUSK PTK7

1.04e-0466379112.60.40.10
DomainIg_I-set

LRIG2 LRIT2 LRRN3 DCC MUSK PTK7

1.54e-04190796IPR013098
DomainI-set

LRIG2 LRIT2 LRRN3 DCC MUSK PTK7

1.54e-04190796PF07679
DomainIg-like_fold

LRIG2 EPOR LRIT2 LRRN3 INSRR OSCAR VSIG10L ILDR1 DCC MUSK PTK7

1.81e-047067911IPR013783
DomainIG_LIKE

LRIG2 LRIT2 LRRN3 OSCAR VSIG10L ILDR1 DCC MUSK PTK7

2.24e-04491799PS50835
DomainIg-like_dom

LRIG2 LRIT2 LRRN3 OSCAR VSIG10L ILDR1 DCC MUSK PTK7

2.68e-04503799IPR007110
DomainFN3

EPOR LRIT2 LRRN3 INSRR DCC

1.13e-03185795SM00060
DomainRECEPTOR_TYR_KIN_II

INSRR PTK7

1.13e-0312792PS00239
DomainFN3

EPOR LRIT2 LRRN3 INSRR DCC

1.55e-03199795PS50853
DomainLRR

LRIG2 LRIT2 LRRN3 LRRC56 PIDD1

1.62e-03201795PS51450
DomainFN3_dom

EPOR LRIT2 LRRN3 INSRR DCC

1.93e-03209795IPR003961
DomainCrotonase_core_superfam

ECHDC3 ECI2

2.31e-0317792IPR001753
DomainECH_1

ECHDC3 ECI2

2.31e-0317792PF00378
DomainLRR_1

LRIG2 LRIT2 LRRN3 LRRC56 PIDD1

2.36e-03219795PF00560
DomainTSP_1

ADAMTS13 THSD1 SSPOP

2.41e-0363793PF00090
DomainTSP1

ADAMTS13 THSD1 SSPOP

2.63e-0365793SM00209
DomainTSP1_rpt

ADAMTS13 THSD1 SSPOP

2.63e-0365793IPR000884
DomainTSP1

ADAMTS13 THSD1 SSPOP

2.63e-0365793PS50092
DomainL_dom-like

LRIG2 LRIT2 LRRN3 INSRR LRRC56 PIDD1

2.66e-03328796IPR032675
Domain-

ECHDC3 ECI2

3.52e-03217923.90.226.10
DomainClpP/crotonase-like_dom

ECHDC3 ECI2

3.52e-0321792IPR029045
DomainProt_kinase_dom

TGFBR1 INSRR AKT1 AKT2 MUSK MOS PTK7

4.62e-03489797IPR000719
DomainPROTEIN_KINASE_DOM

TGFBR1 INSRR AKT1 AKT2 MUSK MOS PTK7

4.83e-03493797PS50011
Domainfn3

EPOR LRRN3 INSRR DCC

4.95e-03162794PF00041
DomainProtein_kinase_ATP_BS

TGFBR1 INSRR AKT1 AKT2 MUSK MOS

5.38e-03379796IPR017441
DomainLeu-rich_rpt

LRIG2 LRIT2 LRRN3 LRRC56 PIDD1

5.83e-03271795IPR001611
DomainLRR_8

LRIG2 LRIT2 LRRN3 PIDD1

5.98e-03171794PF13855
DomainTyrKc

INSRR MUSK PTK7

6.18e-0388793SM00219
DomainTyr_kinase_cat_dom

INSRR MUSK PTK7

6.18e-0388793IPR020635
DomainCys-rich_flank_reg_C

LRIG2 LRIT2 LRRN3

6.57e-0390793IPR000483
DomainLRRCT

LRIG2 LRIT2 LRRN3

6.57e-0390793SM00082
DomainLeu-rich_rpt_typical-subtyp

LRIG2 LRIT2 LRRN3 PIDD1

6.75e-03177794IPR003591
DomainLRR_TYP

LRIG2 LRIT2 LRRN3 PIDD1

6.75e-03177794SM00369
DomainKinase-like_dom

TGFBR1 INSRR AKT1 AKT2 MUSK MOS PTK7

7.99e-03542797IPR011009
DomainLRRCT

LRIG2 LRRN3

8.07e-0332792PF01463
DomainPROTEIN_KINASE_TYR

INSRR MUSK PTK7

8.08e-0397793PS00109
DomainTyr_kinase_AS

INSRR MUSK PTK7

8.08e-0397793IPR008266
PathwayWP_JAKSTAT_SIGNALING_IN_THE_REGULATION_OF_BETA_CELLS

EPOR AKT1 AKT2 STAT1

1.25e-0534604M48081
PathwayWP_INVOLVEMENT_OF_SECRETASE_IN_NEURODEGENERATIVE_DISEASES

AKT1 AKT2 STAT1

4.78e-0517603M48086
PathwayKEGG_COLORECTAL_CANCER

TGFBR1 AKT1 AKT2 DCC

1.38e-0462604M14631
PathwayKEGG_MEDICUS_VARIANT_LOSS_OF_NKX3_1_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.77e-045602M48999
PathwayPID_INSULIN_GLUCOSE_PATHWAY

GYS1 AKT1 AKT2

1.78e-0426603M247
PathwayWP_GROWTH_FACTORS_AND_HORMONES_IN_BETA_CELL_PROLIFERATION

TGFBR1 AKT1 AKT2

1.78e-0426603M48092
PathwayWP_EPO_RECEPTOR_SIGNALING

EPOR AKT1 STAT1

1.78e-0426603M39687
PathwayWP_EPO_RECEPTOR_SIGNALING

EPOR AKT1 STAT1

1.78e-0426603MM15896
PathwayKEGG_PANCREATIC_CANCER

TGFBR1 AKT1 AKT2 STAT1

2.20e-0470604M9726
PathwayWP_CHROMOSOMAL_AND_MICROSATELLITE_INSTABILITY_IN_COLORECTAL_CANCER

TGFBR1 AKT1 AKT2 DCC

2.59e-0473604M39758
PathwayKEGG_MEDICUS_REFERENCE_MAGI_PTEN_SIGNALING_PATHWAY

AKT1 AKT2

2.64e-046602M47523
PathwayWP_CANCER_PATHWAYS

MST1 TGFBR1 EPOR AKT1 LAMC3 AKT2 DCC EDN1 STAT1

2.70e-04507609M48302
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_PI3K_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

3.69e-047602M47407
PathwayKEGG_MEDICUS_REFERENCE_ACH_CHRN_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

3.69e-047602M47790
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47399
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_EGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47394
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47395
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47404
PathwayKEGG_MEDICUS_VARIANT_EML4_ALK_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47405
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47803
PathwayREACTOME_RUNX2_REGULATES_GENES_INVOLVED_IN_CELL_MIGRATION

AKT1 AKT2

4.91e-048602M27806
PathwayKEGG_MEDICUS_VARIANT_TGFA_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47482
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47498
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_RET_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

4.91e-048602M47715
PathwayWP_PANCREATIC_ADENOCARCINOMA_PATHWAY

TGFBR1 AKT1 AKT2 STAT1

5.53e-0489604M39732
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS13 THSD1 SSPOP

6.01e-0439603M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTS13 THSD1 SSPOP

6.01e-0439603MM15165
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47397
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47392
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KRAS_NRAS_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47391
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47402
PathwayKEGG_MEDICUS_REFERENCE_MEMBRANE_INITIATED_PROGESTERONE_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47802
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_MET_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47490
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47481
PathwayREACTOME_ESTROGEN_DEPENDENT_NUCLEAR_EVENTS_DOWNSTREAM_OF_ESR_MEMBRANE_SIGNALING

AKT1 AKT2

6.29e-049602MM15666
PathwayKEGG_MEDICUS_REFERENCE_ICOSLG_ICOS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

6.29e-049602M47972
PathwayKEGG_MEDICUS_VARIANT_EGFR_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

7.84e-0410602M47400
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

7.84e-0410602M47401
PathwayKEGG_MEDICUS_REFERENCE_CD80_CD86_CD28_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

7.84e-0410602M47615
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS

AKT1 AKT2

7.84e-0410602M27095
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_NUCLEUS

AKT1 AKT2

7.84e-0410602MM14778
PathwayKEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

9.56e-0411602M47797
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

9.56e-0411602M47403
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

9.56e-0411602M47406
PathwayKEGG_MEDICUS_REFERENCE_IGF2_IGF1R_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

9.56e-0411602M47484
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

9.56e-0411602M47499
PathwayKEGG_MEDICUS_REFERENCE_NRG_ERBB4_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

9.56e-0411602M47756
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01339

AKT1 AKT2

9.56e-0411602M47791
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

9.56e-0411602M47501
PathwayPID_A6B1_A6B4_INTEGRIN_PATHWAY

MST1 AKT1 LAMC3

9.77e-0446603M239
PathwayKEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.14e-0312602M47393
PathwayKEGG_MEDICUS_ENV_FACTOR_NNK_NNN_TO_PI3K_SIGNALING_PATHWAY_N01350

AKT1 AKT2

1.14e-0312602M47798
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

AKT1 AKT2

1.14e-0312602M47558
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

AKT1 AKT2

1.14e-0312602M47559
PathwayREACTOME_SARS_COV_2_TARGETS_HOST_INTRACELLULAR_SIGNALLING_AND_REGULATORY_PATHWAYS

AKT1 AKT2

1.14e-0312602M45022
PathwayREACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS

AKT1 AKT2

1.14e-0312602MM15657
PathwayREACTOME_REGULATION_OF_LOCALIZATION_OF_FOXO_TRANSCRIPTION_FACTORS

AKT1 AKT2

1.14e-0312602M27939
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL

AKT1 AKT2

1.14e-0312602MM14777
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

AKT1 AKT2

1.14e-0312602MM14550
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS13 THSD1 SSPOP B3GNT8

1.18e-03109604MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTS13 THSD1 SSPOP B3GNT8

1.26e-03111604M27416
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.35e-0313602M47398
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.35e-0313602M47603
PathwayREACTOME_DOWNREGULATION_OF_ERBB2_ERBB3_SIGNALING

AKT1 AKT2

1.35e-0313602M549
PathwayPID_KIT_PATHWAY

EPOR AKT1 STAT1

1.40e-0352603M231
PathwayWP_NRP1TRIGGERED_SIGNALING_IN_PANCREATIC_CANCER

TGFBR1 AKT1 AKT2

1.56e-0354603M42568
PathwayBIOCARTA_ACH_PATHWAY

AKT1 MUSK

1.57e-0314602M16884
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.57e-0314602M47390
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS

AKT1 AKT2

1.57e-0314602MM15341
PathwayREACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ASSOCIATION_WITH_CO_FACTORS

AKT1 AKT2

1.57e-0314602M27638
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY

AKT1 AKT2

1.57e-0314602M47467
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY

AKT1 AKT2

1.57e-0314602M47536
PathwayBIOCARTA_ACH_PATHWAY

AKT1 MUSK

1.57e-0314602MM1485
PathwayREACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL

AKT1 AKT2

1.57e-0314602M3862
PathwayWP_CARDIAC_HYPERTROPHIC_RESPONSE

TGFBR1 AKT1 AKT2

1.64e-0355603M39685
PathwayWP_RANKLRANK_SIGNALING

AKT1 AKT2 STAT1

1.64e-0355603M39667
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.81e-0315602M47389
PathwayKEGG_MEDICUS_REFERENCE_RELN_VLDLR_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.81e-0315602M47663
PathwayREACTOME_ACTIVATION_OF_BAD_AND_TRANSLOCATION_TO_MITOCHONDRIA

AKT1 AKT2

1.81e-0315602M26902
PathwayWP_TRANSCRIPTION_FACTORS_REGULATE_MIRNAS_RELATED_TO_CARDIAC_HYPERTROPHY

AKT1 AKT2

1.81e-0315602M39431
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.81e-0315602M47475
PathwayWP_RIOK1_AND_RIOK2_IN_EGFR_AND_PI3KMEDIATED_TUMORIGENESIS

AKT1 AKT2

1.81e-0315602M48306
PathwayKEGG_MEDICUS_REFERENCE_BCR_BCAP_CD19_PI3K_SIGNALING_PATHWAY

AKT1 AKT2

1.81e-0315602M47971
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

TBXA2R XCR1 DGKI EDN1 EDN2

1.96e-03210605MM15043
PathwayREACTOME_G_ALPHA_Q_SIGNALLING_EVENTS

TBXA2R XCR1 DGKI EDN1 EDN2

2.27e-03217605M18437
PathwaySA_PTEN_PATHWAY

AKT1 AKT2

2.33e-0317602M12771
PathwaySA_TRKA_RECEPTOR

AKT1 AKT2

2.33e-0317602M18895
PathwayPID_ENDOTHELIN_PATHWAY

AKT1 EDN1 EDN2

2.43e-0363603M8
PathwayKEGG_PATHWAYS_IN_CANCER

TGFBR1 AKT1 LAMC3 AKT2 DCC STAT1

2.52e-03325606M12868
PathwayBIOCARTA_CHEMICAL_PATHWAY

AKT1 STAT1

2.61e-0318602MM1350
PathwayBIOCARTA_CHEMICAL_PATHWAY

AKT1 STAT1

2.61e-0318602M3873
PathwayWP_AMPACTIVATED_PROTEIN_KINASE_SIGNALING

GYS1 AKT1 AKT2

2.89e-0367603M39630
PathwayWP_TGFBETA_SIGNALING_IN_THYROID_CELLS_FOR_EPITHELIALMESENCHYMAL_TRANSITION

AKT1 AKT2

2.91e-0319602M39370
PathwayKEGG_MEDICUS_REFERENCE_PP2A_AKT_SIGNALING_PATHWAY

AKT1 AKT2

2.91e-0319602M47525
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTS13 THSD1 SSPOP

3.02e-0368603M27303
PathwayWP_KIT_RECEPTOR_SIGNALING_PATHWAY

EPOR AKT1 STAT1

3.41e-0371603MM15947
PathwayREACTOME_REGULATION_OF_GENE_EXPRESSION_IN_BETA_CELLS

AKT1 AKT2

3.55e-0321602M14966
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

AKT1 AKT2

3.55e-0321602M5876
PathwayPID_ECADHERIN_KERATINOCYTE_PATHWAY

AKT1 AKT2

3.55e-0321602M184
PathwayREACTOME_CTLA4_INHIBITORY_SIGNALING

AKT1 AKT2

3.55e-0321602MM14996
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 B4GALNT4 MROH1 GTSE1 TMC6 LRRC56 AKT1 LAMC3 AKT2 CACNA1H MAPKBP1 CDC14B PRRT4 ABCC10

5.31e-071105861435748872
Pubmed

Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

TELO2 HAGHL CACNA1H EME2 MSLN

1.16e-067486511157797
Pubmed

HIV-1 Tat co-operates with IFN-gamma and TNF-alpha to increase CXCL10 in human astrocytes.

AKT1 AKT2 STAT1

1.73e-061086319479051
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

LRIG2 LRIT2 LRRN3 ILDR1 DCC PTK7

3.22e-0616286625826454
Pubmed

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos.

TGFBR1 AKT1 AKT2

5.21e-061486312773577
Pubmed

Different functions of AKT1 and AKT2 in molecular pathways, cell migration and metabolism in colon cancer cells.

AKT1 AKT2

6.04e-06286227878243
Pubmed

BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.

AKT1 AKT2

6.04e-06286227699769
Pubmed

Isoform-Specific Role of Akt in Oral Squamous Cell Carcinoma.

AKT1 AKT2

6.04e-06286231252679
Pubmed

Endothelin-1 and transforming growth factor-beta1 independently induce fibroblast resistance to apoptosis via AKT activation.

AKT1 EDN1

6.04e-06286219188658
Pubmed

Akt1 is critical for acute inflammation and histamine-mediated vascular leakage.

AKT1 AKT2

6.04e-06286219622728
Pubmed

Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients.

AKT1 AKT2

6.04e-06286228271235
Pubmed

Role of Akt in cardiac growth and metabolism.

AKT1 AKT2

6.04e-06286217019809
Pubmed

Knockout of Akt1/2 suppresses the metastasis of human prostate cancer cells CWR22rv1 in vitro and in vivo.

AKT1 AKT2

6.04e-06286233377281
Pubmed

Akt2 mRNA is highly expressed in embryonic brown fat and the AKT2 kinase is activated by insulin.

AKT1 AKT2

6.04e-0628629620559
Pubmed

Akt1 and Akt2 differently regulate muscle creatine kinase and myogenin gene transcription in insulin-induced differentiation of C2C12 myoblasts.

AKT1 AKT2

6.04e-06286211861503
Pubmed

Akt regulates basic helix-loop-helix transcription factor-coactivator complex formation and activity during neuronal differentiation.

AKT1 AKT2

6.04e-06286212808085
Pubmed

Impaired expression and insulin-stimulated phosphorylation of Akt-2 in muscle of obese patients with atypical diabetes.

AKT1 AKT2

6.04e-06286215010337
Pubmed

Reducing Akt2 in retinal pigment epithelial cells causes a compensatory increase in Akt1 and attenuates diabetic retinopathy.

AKT1 AKT2

6.04e-06286236229454
Pubmed

Endothelin system in intestinal villi: A possible role of endothelin-2/vasoactive intestinal contractor in the maintenance of intestinal architecture.

EDN1 EDN2

6.04e-06286222209790
Pubmed

Akt2 regulates cardiac metabolism and cardiomyocyte survival.

AKT1 AKT2

6.04e-06286216950770
Pubmed

Akt isoforms differentially regulate neutrophil functions.

AKT1 AKT2

6.04e-06286220332370
Pubmed

Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.

AKT1 AKT2

6.04e-0628623037531
Pubmed

PHF19 and Akt control the switch between proliferative and invasive states in melanoma.

PHF19 AKT1

6.04e-06286222487681
Pubmed

High-intensity muscle contraction-mediated increases in Akt1 and Akt2 phosphorylation do not contribute to mTORC1 activation and muscle protein synthesis.

AKT1 AKT2

6.04e-06286232078465
Pubmed

Defining Akt actions in muscle differentiation.

AKT1 AKT2

6.04e-06286223076793
Pubmed

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer.

AKT1 AKT2

6.04e-06286219110052
Pubmed

Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice.

AKT1 AKT2

6.04e-06286223919516
Pubmed

Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors.

AKT1 AKT2

6.04e-06286217804734
Pubmed

Altered endothelin expression in granulosa-lutein cells of women with polycystic ovary syndrome.

EDN1 EDN2

6.04e-06286222727793
Pubmed

Lack of AKT in adipocytes causes severe lipodystrophy.

AKT1 AKT2

6.04e-06286227408773
Pubmed

Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.

AKT1 AKT2

6.04e-06286217141631
Pubmed

PI3K/AKT Signaling in Breast Cancer Molecular Subtyping and Lymph Node Involvement.

AKT1 AKT2

6.04e-06286231781306
Pubmed

Extensive contacts between ADAMTS13 exosites and von Willebrand factor domain A2 contribute to substrate specificity.

ADAMTS13 VWA2

6.04e-06286218492952
Pubmed

Endothelin-1 mediated glycosaminoglycan synthesizing gene expression involves NOX-dependent transactivation of the transforming growth factor-β receptor.

TGFBR1 EDN1

6.04e-06286234982346
Pubmed

Akt-1 and Akt-2 Differentially Regulate the Development of Experimental Autoimmune Encephalomyelitis by Controlling Proliferation of Thymus-Derived Regulatory T Cells.

AKT1 AKT2

6.04e-06286230692211
Pubmed

Role of endothelin-1 in the skin fibrosis of systemic sclerosis.

AKT1 EDN1

6.04e-06286225990837
Pubmed

Distinct actions of akt1 on skeletal architecture and function.

AKT1 AKT2

6.04e-06286224663486
Pubmed

Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression.

AKT1 AKT2

6.04e-06286219491266
Pubmed

Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.

AKT1 AKT2

6.04e-06286217609365
Pubmed

Identification of functional domains in AKT responsible for distinct roles of AKT isoforms in pressure-stimulated cancer cell adhesion.

AKT1 AKT2

6.04e-06286217825284
Pubmed

The G Protein-Coupled Bile Acid Receptor TGR5 (Gpbar1) Modulates Endothelin-1 Signaling in Liver.

GPBAR1 EDN1

6.04e-06286231752395
Pubmed

Depletion of Akt1 and Akt2 Impairs the Repair of Radiation-Induced DNA Double Strand Breaks via Homologous Recombination.

AKT1 AKT2

6.04e-06286231847370
Pubmed

Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis.

AKT1 AKT2

6.04e-06286226654940
Pubmed

Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions.

AKT1 AKT2

6.04e-06286216923802
Pubmed

Role of AMPK and Akt in triple negative breast cancer lung colonization.

AKT1 AKT2

6.04e-06286233839456
Pubmed

Akt1 and Akt2: differentiating the aktion.

AKT1 AKT2

6.04e-06286221432781
Pubmed

Molecular alterations in AKT and its protein activation in human lung carcinomas.

AKT1 AKT2

6.04e-06286222748472
Pubmed

Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner.

AKT1 AKT2

6.04e-06286217045205
Pubmed

Akt1 and Akt2 Isoforms Play Distinct Roles in Regulating the Development of Inflammation and Fibrosis Associated with Alcoholic Liver Disease.

AKT1 AKT2

6.04e-06286231671832
Pubmed

PKB signaling and atrogene expression in skeletal muscle of aged mice.

AKT1 AKT2

6.04e-06286221551011
Pubmed

Differential phosphorylation of Akt1 and Akt2 by protein kinase CK2 may account for isoform specific functions.

AKT1 AKT2

6.04e-06286224769357
Pubmed

A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13.

ADAMTS13 VWA2

6.04e-06286221385852
Pubmed

Distinct and specific roles of AKT1 and AKT2 in androgen-sensitive and androgen-independent prostate cancer cells.

AKT1 AKT2

6.04e-06286223567263
Pubmed

Akt acts as a switch for GPCR transactivation of the TGF-β receptor type 1.

TGFBR1 AKT1

6.04e-06286234826189
Pubmed

Distinct roles of Akt1 and Akt2 in regulating cell migration and epithelial-mesenchymal transition.

AKT1 AKT2

6.04e-06286216365168
Pubmed

Prognostic significance of activated Akt expression in pancreatic ductal adenocarcinoma.

AKT1 AKT2

6.04e-06286215102693
Pubmed

AKT1 and AKT2 induce distinct phosphorylation patterns in HL-1 cardiac myocytes.

AKT1 AKT2

6.04e-06286225162660
Pubmed

The Akt1 isoform is an essential mediator of ischaemic preconditioning.

AKT1 AKT2

6.04e-06286222117619
Pubmed

Distinct actions of Akt1 and Akt2 in skeletal muscle differentiation.

AKT1 AKT2

6.04e-06286219142853
Pubmed

Akt1/Akt2 and mammalian target of rapamycin/Bim play critical roles in osteoclast differentiation and survival, respectively, whereas Akt is dispensable for cell survival in isolated osteoclast precursors.

AKT1 AKT2

6.04e-06286215545269
Pubmed

Loss of PKBβ/Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo.

AKT1 AKT2

6.04e-06286222275470
Pubmed

Specific and redundant roles of PKBα/AKT1 and PKBβ/AKT2 in human pancreatic islets.

AKT1 AKT2

6.04e-06286226318486
Pubmed

Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates.

AKT1 AKT2

6.04e-06286225136137
Pubmed

Differential function of Akt1 and Akt2 in human adipocytes.

AKT1 AKT2

6.04e-06286222480544
Pubmed

Inhibition of JAK/STAT signaling pathway prevents high-glucose-induced increase in endothelin-1 synthesis in human endothelial cells.

EDN1 STAT1

6.04e-06286220217138
Pubmed

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization.

AKT1 AKT2

6.04e-06286222647600
Pubmed

Akt isoform-specific inhibition of MDA-MB-231 cell proliferation.

AKT1 AKT2

6.04e-06286220688159
Pubmed

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium.

AKT1 AKT2

6.04e-06286226971877
Pubmed

Significance of Akt activation and AKT gene increases in soft tissue tumors.

AKT1 AKT2

6.04e-06286224321521
Pubmed

A novel peptide, vasoactive intestinal contractor, of a new (endothelin) peptide family. Molecular cloning, expression, and biological activity.

EDN1 EDN2

6.04e-0628622768235
Pubmed

Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1.

NPC1 AKT1

6.04e-06286226283546
Pubmed

Endothelin converting enzyme (ECE) activity in human vascular smooth muscle.

EDN1 EDN2

6.04e-0628629422810
Pubmed

Akt as a target for cancer therapy: more is not always better (lessons from studies in mice).

AKT1 AKT2

6.04e-06286228557977
Pubmed

Redundant roles of AKT1 and AKT2 in fertility, estrous cyclicity and endometrial gland development.

AKT1 AKT2

6.04e-06286237053038
Pubmed

Involvement of Endothelin Receptors in Peripheral Sensory Neuropathy Induced by Oxaliplatin in Mice.

EDN1 EDN2

6.04e-06286231228092
Pubmed

Roles of AKT1 and AKT2 in non-small cell lung cancer cell survival, growth, and migration.

AKT1 AKT2

6.04e-06286221722267
Pubmed

Increased gene expression of endothelin-1 and vasoactive intestinal contractor/endothelin-2 in the mammary gland of lactating mice.

EDN1 EDN2

6.04e-06286212372435
Pubmed

Opposing Actions of AKT (Protein Kinase B) Isoforms in Vascular Smooth Muscle Injury and Therapeutic Response.

AKT1 AKT2

6.04e-06286229025710
Pubmed

Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.

AKT1 AKT2

6.04e-06286222228739
Pubmed

Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region.

AKT1 AKT2

6.04e-06286233253205
Pubmed

Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis.

AKT1 AKT2

6.04e-06286216075056
Pubmed

IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.

AKT1 AKT2

6.04e-06286218042802
Pubmed

Sequence analysis and expression of the mouse full-length vasoactive intestinal contractor/endothelin-2 gene (EDN2): comparison with the endothelin-1 gene (EDN1).

EDN1 EDN2

6.04e-06286212193061
Pubmed

Expression of endothelin-1 and vasoactive intestinal contractor genes in mouse organs during the perinatal period.

EDN1 EDN2

6.04e-06286212193078
Pubmed

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species.

AKT1 AKT2

6.04e-06286220354168
Pubmed

The role of Akt in the signaling pathway of the glycoprotein Ib-IX induced platelet activation.

AKT1 AKT2

6.04e-06286217914025
Pubmed

Prostaglandin endoperoxide synthase-2 contributes to the endothelin/sarafotoxin-induced prostaglandin E2 synthesis in mouse osteoblastic cells (MC3T3-E1): evidence for a protein tyrosine kinase-signaling pathway and involvement of protein kinase C.

EDN1 EDN2

6.04e-0628629492062
Pubmed

AKT1 and AKT2 isoforms play distinct roles during breast cancer progression through the regulation of specific downstream proteins.

AKT1 AKT2

6.04e-06286228287129
Pubmed

Distinct roles of AKT isoforms in regulating β1-integrin activity, migration, and invasion in prostate cancer.

AKT1 AKT2

6.04e-06286222809628
Pubmed

Iris Nertschinskia ethanol extract differentially induces cytotoxicity in human breast cancer cells depending on AKT1/2 activity.

AKT1 AKT2

6.04e-06286223464484
Pubmed

Akt1 and Akt2 promote peripheral B-cell maturation and survival.

AKT1 AKT2

6.04e-06286220042722
Pubmed

Functional and autoradiographic studies of endothelin-1 and endothelin-2 in human bronchi, pulmonary arteries, and airway parasympathetic ganglia.

EDN1 EDN2

6.04e-0628621725334
Pubmed

Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.

AKT1 AKT2

6.04e-06286226828791
Pubmed

Deletion of PKBalpha/Akt1 affects thymic development.

AKT1 AKT2

1.81e-05386217912369
Pubmed

Differential activation of AKT isoforms by growth factors in human myotubes.

AKT1 AKT2

1.81e-05386237879895
Pubmed

Mitochondrial Akt Regulation of Hypoxic Tumor Reprogramming.

AKT1 AKT2

1.81e-05386227505672
Pubmed

Differentially expressed plasma microRNAs and the potential regulatory function of Let-7b in chronic thromboembolic pulmonary hypertension.

TGFBR1 EDN1

1.81e-05386224978044
Pubmed

Role of thromboxane A2 receptor on the effects of oxidized LDL on microvascular endothelium nitric oxide, endothelin-1, and IL-6 production.

TBXA2R EDN1

1.81e-05386219086263
Pubmed

Differential prognostic values of the three AKT isoforms in acute myeloid leukemia.

AKT1 AKT2

1.81e-05386238528080
Pubmed

Phosphatase and tensin homologue determine inflammatory status by differentially regulating the expression of Akt1 and Akt2 in macrophage alternative polarization of periodontitis.

AKT1 AKT2

1.81e-05386236217693
Cytoband11p15.5

B4GALNT4 C11orf21 LRRC56 PIDD1

7.83e-0511887411p15.5
Cytoband16p13.3

TELO2 HAGHL CACNA1H EME2 MSLN

1.05e-0424487516p13.3
Cytoband17q21.1

STH GPR179

6.60e-042087217q21.1
CytobandEnsembl 112 genes in cytogenetic band chr16p13

TELO2 HAGHL CACNA1H EME2 MSLN

1.33e-03426875chr16p13
Cytoband15q15.1

PAK6-AS1 MAPKBP1

3.63e-034787215q15.1
CytobandEnsembl 112 genes in cytogenetic band chr11p15

B4GALNT4 MRGPRG C11orf21 LRRC56 PIDD1

4.45e-03564875chr11p15
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRIG2 LRIT2 LRRN3 DCC MUSK PTK7

6.59e-06161526593
GeneFamilyReceptor Tyrosine Kinases|CD molecules

INSRR MUSK PTK7

2.06e-0440523321
GeneFamilyImmunoglobulin like domain containing

OSCAR VSIG10L DCC MUSK PTK7

2.28e-04193525594
GeneFamilyFibronectin type III domain containing

EPOR LRRN3 INSRR DCC

1.15e-03160524555
CoexpressionGSE13485_CTRL_VS_DAY3_YF17D_VACCINE_PBMC_DN

GPBAR1 PHF19 C15orf61 VSIG10L SRBD1 ABCC10 STAT1

3.34e-06199837M3286
CoexpressionGSE25123_WT_VS_PPARG_KO_MACROPHAGE_ROSIGLITAZONE_STIM_DN

MST1 SLC12A6 CACNA1H RNF39 ALDOC B3GNT8

2.83e-05186836M7938
CoexpressionNIKOLSKY_BREAST_CANCER_16P13_AMPLICON

TELO2 HAGHL CACNA1H EME2 MSLN

3.88e-05119835M1788
CoexpressionGSE43955_TH0_VS_TGFB_IL6_TH17_ACT_CD4_TCELL_60H_UP

GYS1 GTSE1 TM4SF5 EDN2 MOS MSLN

4.24e-05200836M9655
CoexpressionGSE20366_TREG_VS_NAIVE_CD4_TCELL_HOMEOSTATIC_CONVERSION_UP

NPC1 TBXA2R TGFBR1 TM4SF5 RNF39 CDC14B

4.24e-05200836M4330
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_prolif|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NDUFAF7 FBXW5 TMEM86B LRRC56 ILDR1 ABCC10 MSLN

5.37e-08175877711ace94fa9a763c6ae48171a690953f25deebe4
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap-Excitatory_Neuron.Gad1Gad2.Sphkap-Tmem255a_(Basomedial_amygdaloid_nucleus_(BMA))|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LRIT2 ADAMTS13 RNF39 EDN2

3.55e-0653874db4c0ec659fb1f3196aef6f989f27b25f710c551
ToppCellGlobus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Sphkap-Excitatory_Neuron.Gad1Gad2.Sphkap-Tmem255a_(Basomedial_amygdaloid_nucleus_(BMA))-|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

LRIT2 ADAMTS13 RNF39 EDN2

3.55e-0653874b2b5f47ab9012f08821f2a5f0be24847b5196094
ToppCellControl-APC-like-Monocytes|Control / group, cell type (main and fine annotations)

TBXA2R OSCAR TMEM86B DDX51 EME2

1.71e-051638754bc80a2c741d462724b6f3902377d48c57478932
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GTSE1 ILDR1 CACNA1H SRBD1 ABCC10

1.76e-05164875b92e7c91910d518627376166c6ea9ed333b3d07e
ToppCelldroplet-Lung-18m-Hematologic-lymphocytic-plasma_cell-plasma_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

GTSE1 ILDR1 CACNA1H SRBD1 ABCC10

1.76e-05164875a1e43c6b3e2553f5604100db6e92bf244b70c36d
ToppCellfacs-Marrow-KLS-3m-Hematologic-Unknown_Progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPBAR1 CACNA1H SRBD1 EME2 SSPOP

2.03e-05169875b798b91567d2f49082e2d8a337169f241c8d2080
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nfib_(Amygdala)|Striatum / BrainAtlas - Mouse McCarroll V32

VSIG10L TM4SF5 RNF39 EDN2

2.03e-0582874ab081620b6113f843fede23da0a18720111ffc7c
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Nfib_(Amygdala)-|Striatum / BrainAtlas - Mouse McCarroll V32

VSIG10L TM4SF5 RNF39 EDN2

2.03e-05828741ca848a18463b1344e23e3ad1b5d01ae27c00586
DrugPhosphatidylinositols

TBXA2R GPBAR1 EDN1 EDN2

1.59e-0623864ctd:D010716
DrugYM-16638

TBXA2R NOP9 EDN1

1.80e-067863CID000128491
Drug2a-c

NPC1 AKT1 STAT1 MOS

1.14e-0537864CID000007264
Drugdaltroban

TBXA2R NOP9 EDN1 EDN2

1.41e-0539864CID000054343
Diseasehigh grade glioma (implicated_via_orthology)

EPOR INSRR AKT2 MAPKBP1

7.61e-0644844DOID:3070 (implicated_via_orthology)
Diseaseprostate adenocarcinoma (is_implicated_in)

AKT1 AKT2 STAT1

2.45e-0520843DOID:2526 (is_implicated_in)
Diseasescoliosis (implicated_via_orthology)

SSPOP PTK7

7.96e-055842DOID:0060249 (implicated_via_orthology)
Disease1-(1-enyl-palmitoyl)-2-arachidonoyl-GPE (P-16:0/20:4) measurement

TMEM86B MUSK

7.96e-055842EFO_0800417
DiseaseAdenocarcinoma of large intestine

AKT1 AKT2 DCC PTK7

1.66e-0496844C1319315
Diseaseadult respiratory distress syndrome (implicated_via_orthology)

TBXA2R EDN1

2.85e-049842DOID:11394 (implicated_via_orthology)
DiseaseSubarachnoid Hemorrhage

THSD1 EDN1

2.85e-049842C0038525
Diseasephosphatidylethanolamine ether measurement

TMEM86B MUSK

3.55e-0410842EFO_0010229
Diseasehypertension (is_marker_for)

EPOR EDN1 EDN2

4.70e-0453843DOID:10763 (is_marker_for)
Diseaseintermediate coronary syndrome (is_marker_for)

AKT1 EDN1

6.12e-0413842DOID:8805 (is_marker_for)
Diseaseautosomal dominant polycystic kidney disease (is_marker_for)

GPBAR1 EDN1

7.13e-0414842DOID:898 (is_marker_for)
Diseasechenodeoxycholate measurement

DCC SLC22A20P

8.21e-0415842EFO_0010471
Diseaseidiopathic scoliosis (implicated_via_orthology)

SSPOP PTK7

9.36e-0416842DOID:0060250 (implicated_via_orthology)
Diseasevitamin C measurement

AKT1 MUSK

9.36e-0416842EFO_0600003
DiseasePre-Eclampsia

STOX1 EDN1

9.36e-0416842C0032914
Diseasemyocardial infarction (biomarker_via_orthology)

TGFBR1 EPOR EDN1 EDN2

1.15e-03160844DOID:5844 (biomarker_via_orthology)
DiseaseC-X-C motif chemokine 16 measurement

XCR1 TM4SF5

1.19e-0318842EFO_0010911
Diseaselevel of Phosphatidylcholine (18:1_20:4) in blood serum

DCC MUSK

1.62e-0321842OBA_2045104
Diseasemalignant astrocytoma (is_marker_for)

AKT1 AKT2

1.95e-0323842DOID:3069 (is_marker_for)
DiseaseBradycardia

EDN1 EDN2

2.49e-0326842C0428977
DiseaseColorectal cancer

AKT1 DCC

2.68e-0327842cv:C0346629
DiseaseCOLORECTAL CANCER

AKT1 DCC

2.68e-0327842114500
DiseaseNeoplasm of the large intestine

AKT1 DCC

2.68e-0327842cv:C0009404

Protein segments in the cluster

PeptideGeneStartEntry
ERPRPNTFIIRCLQW

AKT1

66

P31749
ERPRPNTFVIRCLQW

AKT2

66

P31751
KDRFCQLLWRPRPPT

EIF3B

696

P55884
AINRCPLPRPWALTF

ALDOC

286

P09972
ERRSSWAAAPPCSRR

CDC14B

6

O60729
RRNFLTCLSSWKIPP

ACADSB

16

P45954
ARDPACATFCLRRPW

EDN2

101

P20800
SRHFSLNWRPPCLFE

ANGEL2

71

Q5VTE6
LNWRPPCLFESRTQF

ANGEL2

76

Q5VTE6
QCLSAPWERRISSPA

CD163L1

1221

Q9NR16
RAARTPAAPWARFSA

DENND6B

26

Q8NEG7
PRAGLAWSPCSRRQL

ADAMTS13

256

Q76LX8
PLCRRLWARSASTTP

HAGHL

246

Q6PII5
PCSPGWRLRLAASFL

ABCC10

61

Q5T3U5
SSRFVRLSWRPPAEA

DCC

441

P43146
PLCRVWAALRSNLRT

NOP9

121

Q86U38
SPAPARARLWRALSV

GPR179

1021

Q6PRD1
CSVPWTAFRATPLLR

LRIT2

116

A6NDA9
WDRRLRSPPAGCFFL

GPBAR1

41

Q8TDU6
MCLRRGPWAQLPARF

ECHDC3

16

Q96DC8
RPRPRTFFSWLASQR

FBXW5

551

Q969U6
RWRPSHPPFRSRCQE

ILDR1

431

Q86SU0
APERQRLLPAALACW

MSLN

156

Q13421
LFSPRCADLWPATRQ

MROH1

971

Q8NDA8
WRVSALPTPASRRCS

GTSE1

506

Q9NYZ3
LRCRAPQPAWRFGLF

OSCAR

51

Q8IYS5
LFVWVTCCSTRPRPR

MRGPRG

181

Q86SM5
RRLFTRWGSFCVRNP

NPC1

336

O15118
RPRCPACDQLIFSWR

PRICKLE4

146

Q2TBC4
RNPWFSRLDSPRSRC

LINC01599

121

Q8WXQ3
PFLPRWLAEPNCVRR

DDX51

176

Q8N8A6
PRALSAQRLSPRWCF

DGKI

816

O75912
FSWTCRAARSKPRPR

GDF5-AS1

81

Q5U4N7
NWPRRQPSRGSCALS

FRMD6-AS1

181

P0C7T7
RWLRESCSPLPARHS

FRMD6-AS1

326

P0C7T7
VLLPRCRLNPDSSWA

MAPKBP1

1166

O60336
SRCWQPNPRLRPSFT

INSRR

1226

P14616
APTARGAVRFWCSLP

EPOR

96

P19235
RELRWPPRASARNSC

CCDC177

261

Q9NQR7
LAWRLARRSCPSSLQ

ECI2

6

O75521
PARSLRWTRASPDPC

EME2

111

A4GXA9
PNRVCARSRWPAVFT

MST1

681

P26927
RNIRAPEWPRRASCT

GYS1

686

P13807
RRFLLSAACRSFPQW

B3GNT8

116

Q7Z7M8
TTRPRSWCLRLVCNP

CACNA1H

86

O95180
EAWRCFPNRLPLLSN

CA5BP1

151

Q8WTZ4
PSPPWRLRRSKRCSC

EDN1

41

P05305
IRPWRCLQFAISAPF

SLC22A20P

246

A6NK97
CALQTLLRTPNWRPR

SLC12A6

661

Q9UHW9
RCLLRDPASSWNPER

DELE1

321

Q14154
LWLLFTPPQARRCRE

PIDD1

396

Q9HB75
VIQRCWRPSAAQRPS

MOS

316

P00540
RRTQLEFCPRGSSPW

MIEF2

226

Q96C03
PRNLSFFLTPPCARW

STAT1

481

P42224
PARPAWRSRTRLCLA

SSPOP

3901

A2VEC9
QSRASRPWPFSLLVR

LRRC56

286

Q8IYG6
RLCTCEIRPWFTPRS

LRRN3

31

Q9H3W5
PLCAVARAAIPFIWR

NDUFAF7

11

Q7L592
PVLRCLASRLSPAWL

TELO2

61

Q9Y4R8
CIQNRWRPRSFARPE

SRBD1

466

Q8N5C6
DPTFCPARNRRTSLW

TEX51

126

A0A1B0GUA7
RPNIPNRWQSCEALR

TGFBR1

451

P36897
RAPRWLPACRQKTSL

ABHD10

41

Q9NUJ1
SRALSWAARAARPLP

B4GALNT4

491

Q76KP1
GTRSSRCLRPRPLAW

PAK6-AS1

16

Q8N910
LCRPWASRAAARPKP

C15orf61

16

A6NNL5
SSGKLCPRARRWQPL

C11orf21

116

Q9P2W6
VLRQFWFCRLQAPSP

XCR1

301

P46094
CPRLKHRWFFTSARP

TSR1

126

Q2NL82
WVPLACRSFSLGVPR

MRPL51

16

Q4U2R6
PPACLQVLRDAWRRR

STOX1

76

Q6ZVD7
ISDRLRRNWPPSFLS

SPNS1

441

Q9H2V7
RRNWPPSFLSEFRAL

SPNS1

446

Q9H2V7
WRRFGRPAKCSTPAR

THSD1

436

Q9NS62
NAPCWRGSRRTLAVL

VWA2

256

Q5GFL6
DQPLLTPWFCRRCIF

PHF19

136

Q5T6S3
SPFAPRESWRRAART

PRRT4

546

C9JH25
AQRPDVCRWLSPFIL

TMEM86B

16

Q8N661
IFAAPTRLCRWPALI

STH

11

Q8IWL8
SPAWPRRAVSCSLAR

nan

26

Q8N1X5
RWRNLQPALRARSFC

SLC28A1

61

O00337
LCWARALPSRPGASR

ZSWIM8

506

A7E2V4
SLLANCQAPRRPWLA

TMC6

631

Q7Z403
RPFSRPAVASQRRAW

TBXA2R

136

P21731
LLNRTLWDRCEAPPR

TM4SF5

136

O14894
LRCAAASRPPADITW

VSIG10L

426

Q86VR7
QRCWALSPKDRPSFS

PTK7

1041

Q13308
PAFQPPAWNRLRSSC

UHRF1BP1

451

Q6BDS2
SFCRACLARRWGTPP

RNF39

106

Q9H2S5
CERCLPFFQDRPWAR

LAMC3

301

Q9Y6N6
CSRRKLPAPSWRALS

LRIG2

56

O94898
RLCWSKLPADRPSFT

MUSK

836

O15146