Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH TAF1L MAP4K4 MAST3 DYRK3 DYRK2	2.38e-05	446	189	15	GO:0004674
GeneOntologyMolecularFunction	cytoskeletal protein binding	MYO1G SHROOM3 PDE4B MYO9B MARK3 SYNE1 SPTBN1 CORO1B JAKMIP3 USH1C MAST2 SHROOM2 KIF24 BICD1 ARPC2 DST NF2 ABRAXAS1 SIPA1L1 MACF1 DAAM2 HOOK2 CORO7 MAP4K4 NLRP5	4.30e-05	1099	189	25	GO:0008092
GeneOntologyMolecularFunction	protein serine kinase activity	TNIK TLK2 MARK3 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	4.45e-05	363	189	13	GO:0106310
GeneOntologyMolecularFunction	3',5'-cyclic-AMP phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	4.98e-05	22	189	4	GO:0004115
GeneOntologyMolecularFunction	actin filament binding	MYO1G SHROOM3 MYO9B SYNE1 SPTBN1 CORO1B SHROOM2 ARPC2 SIPA1L1 MACF1	6.33e-05	227	189	10	GO:0051015
GeneOntologyMolecularFunction	3',5'-cyclic-GMP phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	7.12e-05	24	189	4	GO:0047555
GeneOntologyMolecularFunction	3',5'-cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	8.42e-05	25	189	4	GO:0004114
GeneOntologyMolecularFunction	cyclic-nucleotide phosphodiesterase activity	PDE4A PDE4B PDE4C PDE4D	1.15e-04	27	189	4	GO:0004112
GeneOntologyMolecularFunction	protein kinase activity	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH NME7 TAF1L MAP4K4 MAST3 DYRK3 DYRK2	1.97e-04	600	189	16	GO:0004672
GeneOntologyMolecularFunction	actin binding	MYO1G SHROOM3 MYO9B SYNE1 SPTBN1 CORO1B SHROOM2 ARPC2 DST NF2 SIPA1L1 MACF1 DAAM2 CORO7	1.97e-04	479	189	14	GO:0003779
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	DOCK2 TBC1D3H DOCK8 MYO9B DOCK9 MCF2 RGS11 TBC1D3B DENND3 SRGAP1 SIPA1L1 SIPA1L2 DOCK6 TBC1D3G	3.50e-04	507	189	14	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	DOCK2 TBC1D3H DOCK8 MYO9B DOCK9 MCF2 RGS11 TBC1D3B DENND3 SRGAP1 SIPA1L1 SIPA1L2 DOCK6 TBC1D3G	3.50e-04	507	189	14	GO:0030695
GeneOntologyMolecularFunction	procollagen galactosyltransferase activity	COLGALT2 COLGALT1	5.28e-04	4	189	2	GO:0050211
GeneOntologyMolecularFunction	phosphotransferase activity, alcohol group as acceptor	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH NME7 TAF1L MAP4K4 MAST3 DYRK3 DYRK2	1.19e-03	709	189	16	GO:0016773
GeneOntologyBiologicalProcess	cAMP metabolic process	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3	7.86e-08	25	187	6	GO:0046058
GeneOntologyBiologicalProcess	cAMP catabolic process	PDE4A PDE4B PDE4C PDE4D	7.96e-07	9	187	4	GO:0006198
GeneOntologyBiologicalProcess	positive regulation of interleukin-2 production	TRAF6 PDE4B PDE4D SPTBN1 STAT5A STAT5B	2.05e-06	42	187	6	GO:0032743
GeneOntologyBiologicalProcess	cyclic purine nucleotide metabolic process	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3	2.72e-06	44	187	6	GO:0052652
GeneOntologyBiologicalProcess	cyclic nucleotide metabolic process	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3	3.11e-06	45	187	6	GO:0009187
GeneOntologyBiologicalProcess	cyclic nucleotide catabolic process	PDE4A PDE4B PDE4C PDE4D	6.10e-06	14	187	4	GO:0009214
GeneOntologyBiologicalProcess	positive regulation of GTPase activity	TBC1D3H DOCK8 MYO9B DOCK9 RGS11 TBC1D3B SNX13 SIPA1L1 DOCK6 TBC1D3G MAP4K4	1.48e-05	244	187	11	GO:0043547
GeneOntologyBiologicalProcess	regulation of hippo signaling	MARK3 SHANK2 NF2 CORO7 MAP4K4	2.60e-05	39	187	5	GO:0035330
GeneOntologyBiologicalProcess	regulation of G protein-coupled receptor signaling pathway	PDE4A PDE4B PDE4D RPGRIP1L GRK5 RGS11 BICD1 NMT2 FGF8	4.20e-05	181	187	9	GO:0008277
GeneOntologyBiologicalProcess	regulation of interleukin-2 production	TRAF6 PDE4B PDE4D SPTBN1 STAT5A STAT5B	5.69e-05	74	187	6	GO:0032663
GeneOntologyBiologicalProcess	negative regulation of relaxation of cardiac muscle	PDE4B PDE4D	8.18e-05	2	187	2	GO:1901898
GeneOntologyBiologicalProcess	regulation of nucleus organization	SYNE1 NFE2L1	8.18e-05	2	187	2	GO:1903353
GeneOntologyBiologicalProcess	regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	PDE4A PDE4B PDE4D GRK5	8.37e-05	26	187	4	GO:0106070
GeneOntologyBiologicalProcess	interleukin-2 production	TRAF6 PDE4B PDE4D SPTBN1 STAT5A STAT5B	1.01e-04	82	187	6	GO:0032623
GeneOntologyBiologicalProcess	hippo signaling	MARK3 SHANK2 NF2 CORO7 MAP4K4	1.40e-04	55	187	5	GO:0035329
GeneOntologyBiologicalProcess	positive regulation of hydrolase activity	TBC1D3H DOCK8 MYO9B DOCK9 CASP9 RGS11 CASC2 TBC1D3B SNX13 MAP3K5 SIPA1L1 DOCK6 TBC1D3G MAP4K4	1.93e-04	499	187	14	GO:0051345
GeneOntologyBiologicalProcess	actin filament-based process	DOCK2 TNIK MYO1G SHROOM3 PDE4B PDE4D MYO9B SPTBN1 ABCC9 SRCIN1 CORO1B USH1C SHROOM2 ARPC2 NF2 SIPA1L1 DAAM2 POTEJ CORO7 NLRP5	2.42e-04	912	187	20	GO:0030029
GeneOntologyBiologicalProcess	metaphase	NFE2L1 HASPIN	2.44e-04	3	187	2	GO:0051323
GeneOntologyBiologicalProcess	development of secondary male sexual characteristics	STAT5A STAT5B	2.44e-04	3	187	2	GO:0046544
GeneOntologyBiologicalProcess	cellular response to potassium ion	ABCC9 SLC12A2 KCNJ10	2.48e-04	14	187	3	GO:0035865
GeneOntologyBiologicalProcess	purine ribonucleotide metabolic process	HNF1A AMPD3 ADCY4 PDE4A PDE4B PDE4C PDE4D ZBTB20 ABCC9 GTPBP1 NDUFB1 ADCY3 ITPA NME7	2.50e-04	512	187	14	GO:0009150
GeneOntologyBiologicalProcess	regulation of GTPase activity	TBC1D3H DOCK8 MYO9B DOCK9 RGS11 TBC1D3B SNX13 SIPA1L1 DOCK6 TBC1D3G MAP4K4	2.53e-04	335	187	11	GO:0043087
MousePheno	absent corpus callosum	RPGRIP1L CASP9 HESX1 ITPR3 NIPBL	1.60e-05	33	137	5	MP:0002196
Domain	DHR-1_domain	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	IPR027007
Domain	DHR_2	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	PS51651
Domain	DHR_1	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	PS51650
Domain	DHR-2	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	PF06920
Domain	DOCK	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	IPR026791
Domain	DOCK_C	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	IPR010703
Domain	DOCK-C2	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	PF14429
Domain	DHR-2	DOCK2 DOCK8 DOCK9 DOCK6	2.91e-06	11	185	4	IPR027357
Domain	DUF1908	MAST2 MAST4 MAST3	3.80e-06	4	185	3	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST2 MAST4 MAST3	3.80e-06	4	185	3	IPR015022
Domain	MAST_pre-PK_dom	MAST2 MAST4 MAST3	3.80e-06	4	185	3	IPR023142
Domain	-	MAST2 MAST4 MAST3	3.80e-06	4	185	3	1.20.1480.20
Domain	Spectrin_repeat	SYNE1 SPTBN1 MCF2 DST MACF1	8.84e-06	29	185	5	IPR002017
Domain	PDZ	SHROOM3 USH1C MAST2 SHROOM2 MAST4 SHANK2 SIPA1L1 SIPA1L2 MAST3	1.15e-05	141	185	9	PF00595
Domain	Ser/Thr_kinase_AS	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	1.35e-05	357	185	14	IPR008271
Domain	S_TKc	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	1.43e-05	359	185	14	SM00220
Domain	SPEC	SYNE1 SPTBN1 MCF2 DST MACF1	1.46e-05	32	185	5	SM00150
Domain	Spectrin/alpha-actinin	SYNE1 SPTBN1 MCF2 DST MACF1	1.46e-05	32	185	5	IPR018159
Domain	PROTEIN_KINASE_ST	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	1.57e-05	362	185	14	PS00108
Domain	PDZ	SHROOM3 USH1C MAST2 SHROOM2 MAST4 SHANK2 SIPA1L1 SIPA1L2 MAST3	1.70e-05	148	185	9	SM00228
Domain	DUF3398	DOCK8 DOCK9 DOCK6	1.87e-05	6	185	3	PF11878
Domain	DOCK_C/D_N	DOCK8 DOCK9 DOCK6	1.87e-05	6	185	3	IPR021816
Domain	-	SHROOM3 USH1C MAST2 SHROOM2 MAST4 SHANK2 SIPA1L1 SIPA1L2 MAST3	1.89e-05	150	185	9	2.30.42.10
Domain	PDZ	SHROOM3 USH1C MAST2 SHROOM2 MAST4 SHANK2 SIPA1L1 SIPA1L2 MAST3	1.99e-05	151	185	9	PS50106
Domain	PDZ	SHROOM3 USH1C MAST2 SHROOM2 MAST4 SHANK2 SIPA1L1 SIPA1L2 MAST3	2.10e-05	152	185	9	IPR001478
Domain	Pkinase	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	2.77e-05	381	185	14	PF00069
Domain	PDEase	PDE4A PDE4B PDE4C PDE4D	3.22e-05	19	185	4	IPR023088
Domain	PDEase_I	PDE4A PDE4B PDE4C PDE4D	4.89e-05	21	185	4	PF00233
Domain	PDEASE_I	PDE4A PDE4B PDE4C PDE4D	4.89e-05	21	185	4	PS00126
Domain	PDEase_CS	PDE4A PDE4B PDE4C PDE4D	4.89e-05	21	185	4	IPR023174
Domain	-	PDE4A PDE4B PDE4C PDE4D	5.93e-05	22	185	4	1.10.1300.10
Domain	Spectrin	SYNE1 SPTBN1 DST MACF1	7.12e-05	23	185	4	PF00435
Domain	ACTININ_2	SYNE1 SPTBN1 DST MACF1	7.12e-05	23	185	4	PS00020
Domain	ACTININ_1	SYNE1 SPTBN1 DST MACF1	7.12e-05	23	185	4	PS00019
Domain	Actinin_actin-bd_CS	SYNE1 SPTBN1 DST MACF1	7.12e-05	23	185	4	IPR001589
Domain	PDEase_catalytic_dom	PDE4A PDE4B PDE4C PDE4D	7.12e-05	23	185	4	IPR002073
Domain	HD/PDEase_dom	PDE4A PDE4B PDE4C PDE4D	8.48e-05	24	185	4	IPR003607
Domain	HDc	PDE4A PDE4B PDE4C PDE4D	8.48e-05	24	185	4	SM00471
Domain	GCFC	GCFC2 PAXBP1	9.76e-05	2	185	2	IPR012890
Domain	Kinase-like_dom	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 DST MAST4 HASPIN MACF1 PRKCH MAP4K4 MAST3 DYRK3 DYRK2	1.02e-04	542	185	16	IPR011009
Domain	PROTEIN_KINASE_ATP	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	2.00e-04	459	185	14	PS00107
Domain	AGC-kinase_C	GRK5 MAST2 MAST4 PRKCH MAST3	2.29e-04	56	185	5	IPR000961
Domain	AGC_KINASE_CTER	GRK5 MAST2 MAST4 PRKCH MAST3	2.29e-04	56	185	5	PS51285
Domain	S_TK_X	GRK5 MAST2 MAST4 PRKCH MAST3	2.29e-04	56	185	5	SM00133
Domain	GCFC_dom	GCFC2 PAXBP1	2.91e-04	3	185	2	IPR022783
Domain	Glyco_transf_25	COLGALT2 COLGALT1	2.91e-04	3	185	2	PF01755
Domain	GCFC	GCFC2 PAXBP1	2.91e-04	3	185	2	PF07842
Domain	SPAR_C	SIPA1L1 SIPA1L2	2.91e-04	3	185	2	PF11881
Domain	Glyco_trans_25	COLGALT2 COLGALT1	2.91e-04	3	185	2	IPR002654
Domain	ASD1	SHROOM3 SHROOM2	2.91e-04	3	185	2	PF08688
Domain	ASD1_dom	SHROOM3 SHROOM2	2.91e-04	3	185	2	IPR014800
Domain	ASD1	SHROOM3 SHROOM2	2.91e-04	3	185	2	PS51306
Domain	SIPA1L_C	SIPA1L1 SIPA1L2	2.91e-04	3	185	2	IPR021818
Domain	Prot_kinase_dom	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	3.80e-04	489	185	14	IPR000719
Domain	RGS	RGSL1 GRK5 RGS11 SNX13	3.84e-04	35	185	4	PF00615
Domain	PROTEIN_KINASE_DOM	TNIK TLK2 MARK3 GRK5 SIK3 MAST2 MAP3K5 MAST4 HASPIN PRKCH MAP4K4 MAST3 DYRK3 DYRK2	4.13e-04	493	185	14	PS50011
Domain	RGS	RGSL1 GRK5 RGS11 SNX13	4.28e-04	36	185	4	PS50132
Domain	CH	SYNE1 SPTBN1 DST ASPM MACF1	4.61e-04	65	185	5	SM00033
Domain	Shroom_fam	SHROOM3 SHROOM2	5.78e-04	4	185	2	IPR027685
Domain	ASD2_dom	SHROOM3 SHROOM2	5.78e-04	4	185	2	IPR014799
Domain	ASD2	SHROOM3 SHROOM2	5.78e-04	4	185	2	PF08687
Domain	ASD2	SHROOM3 SHROOM2	5.78e-04	4	185	2	PS51307
Domain	RGS	RGSL1 GRK5 RGS11 SNX13	5.85e-04	39	185	4	IPR016137
Domain	CH	SYNE1 SPTBN1 DST ASPM MACF1	6.49e-04	70	185	5	PF00307
Domain	-	SYNE1 SPTBN1 DST ASPM MACF1	6.93e-04	71	185	5	1.10.418.10
Domain	CH	SYNE1 SPTBN1 DST ASPM MACF1	7.87e-04	73	185	5	PS50021
Domain	CH-domain	SYNE1 SPTBN1 DST ASPM MACF1	8.90e-04	75	185	5	IPR001715
Domain	-	DST MACF1	1.43e-03	6	185	2	3.90.1290.10
Domain	GAR	DST MACF1	1.43e-03	6	185	2	PS51460
Domain	GAS2	DST MACF1	1.43e-03	6	185	2	PF02187
Domain	-	DST MACF1	1.43e-03	6	185	2	3.30.920.20
Domain	GAS_dom	DST MACF1	1.43e-03	6	185	2	IPR003108
Domain	GAS2	DST MACF1	1.43e-03	6	185	2	SM00243
Domain	Protein_kinase_ATP_BS	TNIK TLK2 MARK3 GRK5 SIK3 MAP3K5 HASPIN PRKCH MAP4K4 DYRK3 DYRK2	1.44e-03	379	185	11	IPR017441
Domain	RabGAP-TBC	TBC1D3H TBC1D3B TBC1D31 TBC1D3G	1.87e-03	53	185	4	PF00566
Domain	STAT_TF_DNA-bd_sub	STAT5A STAT5B	1.98e-03	7	185	2	IPR012345
Domain	STAT	STAT5A STAT5B	1.98e-03	7	185	2	IPR001217
Domain	STAT_int	STAT5A STAT5B	1.98e-03	7	185	2	SM00964
Domain	STAT_TF_DNA-bd	STAT5A STAT5B	1.98e-03	7	185	2	IPR013801
Domain	STAT_bind	STAT5A STAT5B	1.98e-03	7	185	2	PF02864
Domain	STAT_int	STAT5A STAT5B	1.98e-03	7	185	2	PF02865
Domain	Plectin	DST MACF1	1.98e-03	7	185	2	PF00681
Domain	-	STAT5A STAT5B	1.98e-03	7	185	2	1.10.532.10
Domain	Trimer_CC	CORO1B CORO7	1.98e-03	7	185	2	IPR015049
Domain	DUF1899	CORO1B CORO7	1.98e-03	7	185	2	IPR015048
Domain	STAT_alpha	STAT5A STAT5B	1.98e-03	7	185	2	PF01017
Domain	Trimer_CC	CORO1B CORO7	1.98e-03	7	185	2	PF08954
Domain	DUF1899	CORO1B CORO7	1.98e-03	7	185	2	PF08953
Domain	-	STAT5A STAT5B	1.98e-03	7	185	2	1.20.1050.20
Domain	STAT_TF_prot_interaction	STAT5A STAT5B	1.98e-03	7	185	2	IPR013799
Domain	Plectin_repeat	DST MACF1	1.98e-03	7	185	2	IPR001101
Domain	STAT_TF_coiled-coil	STAT5A STAT5B	1.98e-03	7	185	2	IPR015988
Domain	Coronin	CORO1B CORO7	1.98e-03	7	185	2	IPR015505
Domain	-	STAT5A STAT5B	1.98e-03	7	185	2	2.60.40.630
Domain	DUF1899	CORO1B CORO7	1.98e-03	7	185	2	SM01166
Domain	PLEC	DST MACF1	1.98e-03	7	185	2	SM00250
Domain	Rab-GTPase-TBC_dom	TBC1D3H TBC1D3B TBC1D31 TBC1D3G	2.14e-03	55	185	4	IPR000195
Domain	TBC_RABGAP	TBC1D3H TBC1D3B TBC1D31 TBC1D3G	2.14e-03	55	185	4	PS50086
Domain	STAT_TF_alpha	STAT5A STAT5B	2.63e-03	8	185	2	IPR013800
Domain	AC_N	ADCY4 ADCY3	2.63e-03	8	185	2	IPR032628
Pathway	REACTOME_OPIOID_SIGNALLING	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 ITPR3 PLA2G4A	1.94e-06	90	132	8	M6467
Pathway	KEGG_PURINE_METABOLISM	AMPD3 ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 ITPA POLR3B NME7	2.41e-06	159	132	10	M14314
Pathway	REACTOME_OPIOID_SIGNALLING	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 PLA2G4A	4.35e-06	71	132	7	MM14491
Pathway	WP_PURINE_METABOLISM	AMPD3 ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 ITPA POLR3B NME7	4.63e-06	171	132	10	MM15909
Pathway	WP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3	1.20e-05	55	132	6	M39763
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C PDE4D	1.23e-05	16	132	4	MM14699
Pathway	WP_G_PROTEIN_SIGNALING_PATHWAYS	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 PRKCH	2.11e-05	90	132	7	MM15882
Pathway	WP_G_PROTEIN_SIGNALING	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 PRKCH	2.27e-05	91	132	7	M39426
Pathway	WP_SILDENAFIL_TREATMENT	PDE4A PDE4B PDE4C PDE4D	5.67e-05	23	132	4	M46455
Pathway	REACTOME_DARPP_32_EVENTS	PDE4A PDE4B PDE4C PDE4D	6.75e-05	24	132	4	M751
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	ADCY4 PDE4B PDE4D GRK5 RGS11 ADCY3 ITPR3 PRKCH	9.92e-05	154	132	8	MM15974
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	ADCY4 PDE4B PDE4D GRK5 RGS11 ADCY3 ITPR3 PRKCH	1.09e-04	156	132	8	M39475
Pathway	REACTOME_CDC42_GTPASE_CYCLE	DOCK8 MYO9B DOCK9 MCF2 SRGAP1 DOCK6	2.50e-04	94	132	6	MM15598
Pathway	PID_ENDOTHELIN_PATHWAY	ADCY4 ADCY3 SLC9A3 PLA2G4A PRKCH	3.03e-04	63	132	5	M8
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	TNIK RPL36 SHROOM3 MARK3 SYNE1 SPTBN1 SPTLC1 GPAT3 TNIP1 FASTKD2 SIK3 COLGALT1 MAP7 PRPF40A GSR DHX30 ITPR3 PAXBP1 TBC1D31 MDN1 SLC12A2 NF2 BAZ2A ASPM ASCC2 MRPS5 MACF1 CRYBG3 SIPA1L2 NME7 DNA2 MAP4K4 MAST3	5.79e-12	1487	189	33	33957083
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	TNIK TLK2 SHROOM3 PDE4A PDE4B SYNE1 SPTBN1 SPATA20 CORO1B JAKMIP3 SIK3 MAP3K5 ARPC2 KIAA0319 DST MDN1 SHANK2 UBE3A SIPA1L1 KCNJ10 MACF1 WDFY3 MAP4K4 NIPBL RAI1	1.13e-10	963	189	25	28671696
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E SHROOM3 PDE4A RHBDF1 MYO9B DOCK9 GRK5 SPATA20 CORO1B MAST2 LDLR CASZ1 MAP3K5 DHX30 ITPR3 DST MDN1 SHANK2 NF2 ZNF335 HELZ2 ZFYVE26 WDFY3 SIPA1L2 DOCK6 RAI1	3.83e-10	1105	189	26	35748872
Pubmed	Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	4	189	4	9371714
Pubmed	Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	4	189	4	34943270
Pubmed	PAN-selective inhibition of cAMP-phosphodiesterase 4 (PDE4) induces gastroparesis in mice.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	4	189	4	32738081
Pubmed	A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	4	189	4	8413254
Pubmed	Role of phosphodiesterases in the shaping of sub-plasma-membrane cAMP oscillations and pulsatile insulin secretion.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	4	189	4	22946044
Pubmed	Inhibition of cAMP-phosphodiesterase 4 (PDE4) potentiates the anesthetic effects of Isoflurane in mice.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	4	189	4	33609559
Pubmed	Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine.	PDE4A PDE4B PDE4C PDE4D	8.45e-10	4	189	4	24732776
Pubmed	The cAMP-phosphodiesterase 4 (PDE4) controls β-adrenoceptor- and CFTR-dependent saliva secretion in mice.	PDE4A PDE4B PDE4C PDE4D	4.21e-09	5	189	4	33944911
Pubmed	A mouse homolog of dunce, a gene important for learning and memory in Drosophila, is preferentially expressed in olfactory receptor neurons.	PDE4A PDE4B PDE4C PDE4D	4.21e-09	5	189	4	8586960
Pubmed	Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse.	PDE4A PDE4B PDE4C PDE4D TYRP1	5.58e-09	13	189	5	8009369
Pubmed	Distinct roles of PDE4 and PDE10A in the regulation of cAMP/PKA signaling in the striatum.	PDE4A PDE4B PDE4C PDE4D	1.26e-08	6	189	4	18923023
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	TRAF6 SYNE1 SPTBN1 MAGEH1 ZBTB47 XPC VPS54 JAKMIP3 SHROOM2 STAT5B DHX30 BICD1 POLR3B DST NF2 UBE3A SIPA1L1 NMT2 MACF1 RNF216 DAAM2 ZNF350 WDFY3 MAP4K4 NIPBL	3.72e-08	1285	189	25	35914814
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	RPL36 SHROOM3 RHBDF1 MARK3 SYNE1 ZNF652 GOSR1 XPC MAP7 CASZ1 DHX30 RAB18 PAXBP1 DST MDN1 SHANK2 SLC12A2 BAZ2A SIPA1L1 NMT2 HELZ2 ASCC2 MRPS5 MACF1 TAF1L NIPBL ZNF574	4.75e-08	1497	189	27	31527615
Pubmed	The human cytoplasmic dynein interactome reveals novel activators of motility.	TNIK SHROOM3 RPGRIP1L GOSR1 CASP9 CORO1B SIK3 GTPBP1 MAST2 CCDC57 BICD1 ARPC2 ACTR1B TBC1D31 MAST4 SIPA1L1 MPHOSPH9 SIPA1L2 NME7 MAP4K4	4.99e-08	853	189	20	28718761
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNIK MARK3 SYNE1 DOCK9 ADCY3 SNX13 DHX30 KIAA0319 BAZ2A SIPA1L1 MACF1 DAAM2 SIPA1L2 RUBCN	5.89e-08	407	189	14	12693553
Pubmed	The upstream conserved regions (UCRs) mediate homo- and hetero-oligomerization of type 4 cyclic nucleotide phosphodiesterases (PDE4s).	PDE4A PDE4B PDE4D	1.58e-07	3	189	3	24555506
Pubmed	Differential expression and function of phosphodiesterase 4 (PDE4) subtypes in human primary CD4+ T cells: predominant role of PDE4D.	PDE4A PDE4B PDE4D	1.58e-07	3	189	3	17404263
Pubmed	Specific role of phosphodiesterase 4B in lipopolysaccharide-induced signaling in mouse macrophages.	PDE4A PDE4B PDE4D	1.58e-07	3	189	3	16034090
Pubmed	Nonredundant function of phosphodiesterases 4D and 4B in neutrophil recruitment to the site of inflammation.	PDE4A PDE4B PDE4D	1.58e-07	3	189	3	15585880
Pubmed	Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect.	PDE4A PDE4B PDE4D	1.58e-07	3	189	3	10213096
Pubmed	Critical role of PDE4D in beta2-adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts.	PDE4A PDE4B PDE4D	1.58e-07	3	189	3	18508768
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	SHROOM3 MARK3 SPTBN1 SIK3 MAP7 MAST2 DST MDN1 MAST4 SLC12A2 SRGAP1 SIPA1L1 MACF1 MPHOSPH9 CRYBG3 SIPA1L2 DOCK6 MAP4K4 DYRK2	2.78e-07	861	189	19	36931259
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TNIK SYNE1 DOCK9 TNIP1 SIK3 DST SIPA1L1 HELZ2 MACF1 WDFY3	4.82e-07	225	189	10	12168954
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	SHROOM3 PDE4D ZBTB20 ATXN7L1 MARK3 NAIP SRCIN1 VPS54 SHROOM2 CCDC57 CASC2 ADCY3 CASZ1 STAT5B BICD1 SHANK2 NF2 NAXD SHPRH MACF1 HOOK2 SYTL1 DOCK6 TATDN1 RAI1	5.91e-07	1489	189	25	28611215
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	COLGALT2 SIK3 COLGALT1 GTPBP1 MAST2 DENND3 STAT5B KLHL11 DST RNF216 HOOK2 CRYBG3 DNA2 MAP4K4 RUBCN ZNF574	6.15e-07	650	189	16	38777146
Pubmed	Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.	PDE4A PDE4B PDE4D	6.29e-07	4	189	3	21670503
Pubmed	Phosphodiesterase 4D is required for beta2 adrenoceptor subtype-specific signaling in cardiac myocytes.	PDE4A PDE4B PDE4D	6.29e-07	4	189	3	15644445
Pubmed	Inhibition of PDE3B augments PDE4 inhibitor-induced apoptosis in a subset of patients with chronic lymphocytic leukemia.	PDE4A PDE4B PDE4D	6.29e-07	4	189	3	11839681
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK2 DOCK8 DOCK9 DOCK6	8.10e-07	14	189	4	12432077
Pubmed	Functional proteomics mapping of a human signaling pathway.	DOCK8 SPTBN1 TNIP1 XPC PRPF40A DHX30 DST MAST4 SUSD1 UBE3A ASCC2 MACF1 RNF216 ZNF350 RUBCN	9.58e-07	591	189	15	15231748
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	ADCY4 RPL36 PDE4D DOCK8 MARK3 SYNE1 SPTBN1 SRCIN1 CORO1B MAP7 GTPBP1 SHROOM2 PRPF40A EIF3CL DHX30 ARPC2 DST SHANK2 SIPA1L1 NMT2 KCNQ3 MACF1 SIPA1L2 CORO7	1.03e-06	1431	189	24	37142655
Pubmed	Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma.	TNIK RHBDF1 MARK3 DOCK9 SPTBN1 SPTLC1 ADCY3 DST SLC12A2 NF2 DAAM2 MAP4K4	1.20e-06	377	189	12	38117590
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	TLK2 PDE4C GCFC2 SPTBN1 XPC PRPF40A EIF3CL PAXBP1 MDN1 USP42 BAZ2A SIPA1L1 ZNF335 HELZ2 PLA2G4A MAP4K4 NIPBL	1.29e-06	774	189	17	15302935
Pubmed	Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function.	PDE4A PDE4B PDE4D	1.57e-06	5	189	3	21652625
Pubmed	Phosphodiesterase 4B negatively regulates endotoxin-activated interleukin-1 receptor antagonist responses in macrophages.	PDE4A PDE4B PDE4D	1.57e-06	5	189	3	28383060
Pubmed	Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia.	KIAA0408 TNIK PDE4B SYNE1 SPTBN1 BICD1 DST MACF1	1.88e-06	151	189	8	17043677
Pubmed	Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.	COPZ2 MAST4 NFE2L1 PLA2G4A	1.90e-06	17	189	4	22949513
Pubmed	Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.	TNIK APOB LDLR EXOC3L1 DOCK6	2.23e-06	39	189	5	21347282
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DOCK9 SPTBN1 NAIP SRCIN1 GTPBP1 EIF3CL DST SHANK2 SIPA1L1 MACF1 SIPA1L2	3.52e-06	347	189	11	17114649
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	TNIK PDE4D SYNE1 SPTBN1 SRCIN1 SIK3 SHANK2 SIPA1L1 KCNJ10 MACF1	3.57e-06	281	189	10	28706196
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RPL36 COPZ2 SYNE1 GRK5 SPTBN1 RGS11 APOB XPC CCDC57 GSR ARPC2 DST TBC1D31 MDN1 SHANK2 SUSD1 ASPM MACF1 ZNF350 POTEJ SIPA1L2 NIPBL RAI1	4.07e-06	1442	189	23	35575683
Pubmed	Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	TNIK AMPD3 TRAF6 RPGRIP1L CYP3A43 SPTBN1 ASTE1 SLC30A8 SIK3 USH1C MAST2 CCDC57 KIF24 ARPC2 MDN1 USP42 ASPM APOL4 MRPS5 DAAM2 SYTL1	4.55e-06	1242	189	21	30973865
Pubmed	Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium.	STAT5A STAT5B SLC12A2	5.44e-06	7	189	3	11706048
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	SYNE1 MAST2 PRPF40A DHX30 DST MDN1 ZNF335 ASPM MACF1	5.93e-06	234	189	9	36243803
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	SHROOM3 DOCK8 MARK3 MAST2 DST NF2 SIPA1L1 MPHOSPH9 SIPA1L2 NME7 DOCK6 MAP4K4	6.72e-06	446	189	12	24255178
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ATXN7L1 MAST2 KIAA0319 DST SIPA1L1 MACF1 MAST3	7.53e-06	130	189	7	12421765
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TLK2 PDE4B RHBDF1 ZNF652 DOCK9 SPTBN1 APOB COLGALT1 SHROOM2 LDLR ADCY3 PAXBP1 TBC1D31 NF2 NFE2L1 SIPA1L1 MACF1 EXOC3L1 DNA2	8.05e-06	1084	189	19	11544199
Pubmed	Overview of PDEs and their regulation.	PDE4A PDE4B PDE4C PDE4D	9.77e-06	25	189	4	17307970
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	GPAT3 XPC COLGALT2 SIK3 CASZ1 ITPA CDY1 ITPR3 MDN1 UBE3A WDFY3 POTEJ NIPBL RAI1	1.16e-05	638	189	14	31182584
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TRIM4 ATXN7L1 SPTLC1 XPC SIK3 MAP7 MAST2 PRPF40A LDLR BAZ2A SIPA1L1 ASPM MACF1 WDFY3 CRYBG3 SIPA1L2 DNA2 RAI1 ZNF574	1.21e-05	1116	189	19	31753913
Pubmed	Proximity interactions among centrosome components identify regulators of centriole duplication.	TNIK MARK3 CCDC57 USP42 SIPA1L1 MPHOSPH9	1.96e-05	101	189	6	24613305
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KIAA0408 SYNE1 DOCK9 SPTBN1 TNIP1 MAST2 MAP3K5 DST NF2 NFE2L1 MACF1 HOOK2	1.97e-05	497	189	12	23414517
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TNIK MAP7 DST MAST4 SIPA1L1 MACF1 CRYBG3 SIPA1L2	2.04e-05	209	189	8	36779422
Pubmed	Defining the membrane proteome of NK cells.	DOCK2 MYO1G RPL36 DOCK8 MYO9B DOCK9 GOSR1 COLGALT1 GTPBP1 PRPF40A LDLR ADCY3 ITPR3 ACTR1B MDN1 NF2 HELZ2 MPHOSPH9 CORO7	2.26e-05	1168	189	19	19946888
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KIAA0319 MDN1 MAST4 BAZ2A DAAM2 ZFYVE26	2.32e-05	104	189	6	9205841
Pubmed	TBC1D3, a hominoid oncoprotein, is encoded by a cluster of paralogues located on chromosome 17q12.	TBC1D3H TBC1D3B TBC1D3G	2.52e-05	11	189	3	16863688
Pubmed	The role of microtubule actin cross-linking factor 1 (MACF1) in the Wnt signaling pathway.	HESX1 DST MACF1	2.52e-05	11	189	3	16815997
Pubmed	Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.	STAT5A STAT5B	2.94e-05	2	189	2	23151802
Pubmed	Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.	STAT5A STAT5B	2.94e-05	2	189	2	26999798
Pubmed	Comparison of apolipoprotein B metabolism in familial defective apolipoprotein B and heterogeneous familial hypercholesterolemia.	APOB LDLR	2.94e-05	2	189	2	11947895
Pubmed	Increased production of VLDL apoB-100 in subjects with familial hypercholesterolemia carrying the same null LDL receptor gene mutation.	APOB LDLR	2.94e-05	2	189	2	14967814
Pubmed	[A genetic and clinical study in a family with familial hypercholesterolemia].	APOB LDLR	2.94e-05	2	189	2	21418831
Pubmed	Effects of PDE4 gene polymorphisms on efficacy and adverse drug events of ritodrine therapy in preterm labor patients: a prospective observational study.	PDE4B PDE4D	2.94e-05	2	189	2	31324945
Pubmed	A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.	STAT5A STAT5B	2.94e-05	2	189	2	31443474
Pubmed	Lymphatic insufficiency leads to distinct myocardial infarct content assessed by magnetic resonance TRAFFn, T1ρ and T2 relaxation times.	APOB LDLR	2.94e-05	2	189	2	36709358
Pubmed	Exploiting Glutamine Consumption in Atherosclerotic Lesions by Positron Emission Tomography Tracer (2S,4R)-4-18F-Fluoroglutamine.	APOB LDLR	2.94e-05	2	189	2	35145523
Pubmed	Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.	STAT5A STAT5B	2.94e-05	2	189	2	12377952
Pubmed	Common mutations of familial hypercholesterolemia patients in Taiwan: characteristics and implications of migrations from southeast China.	APOB LDLR	2.94e-05	2	189	2	22353362
Pubmed	Overexpression of phosphodiesterase-4 subtypes involved in surgery-induced neuroinflammation and cognitive dysfunction in mice.	PDE4B PDE4D	2.94e-05	2	189	2	28235598
Pubmed	Neurofibromatosis 2 tumour suppressor schwannomin interacts with betaII-spectrin.	SPTBN1 NF2	2.94e-05	2	189	2	9537418
Pubmed	A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.	STAT5A STAT5B	2.94e-05	2	189	2	21127177
Pubmed	The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.	STAT5A STAT5B	2.94e-05	2	189	2	16289657
Pubmed	Inhibition of Stat5a/b Enhances Proteasomal Degradation of Androgen Receptor Liganded by Antiandrogens in Prostate Cancer.	STAT5A STAT5B	2.94e-05	2	189	2	25552366
Pubmed	Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.	STAT5A STAT5B	2.94e-05	2	189	2	25470773
Pubmed	Acf7 (MACF) is an actin and microtubule linker protein whose expression predominates in neural, muscle, and lung development.	DST MACF1	2.94e-05	2	189	2	11002341
Pubmed	Deletion of the murine ortholog of human 9p21.3 locus promotes atherosclerosis by increasing macrophage proinflammatory activity.	APOB LDLR	2.94e-05	2	189	2	36950286
Pubmed	Constitutively active Stat5A and Stat5B promote adipogenesis.	STAT5A STAT5B	2.94e-05	2	189	2	21431790
Pubmed	LDLR and ApoB are major genetic causes of autosomal dominant hypercholesterolemia in a Taiwanese population.	APOB LDLR	2.94e-05	2	189	2	17964958
Pubmed	Stat5 Is Required for CD103+ Dendritic Cell and Alveolar Macrophage Development and Protection from Lung Injury.	STAT5A STAT5B	2.94e-05	2	189	2	28500076
Pubmed	STAT5 isoforms regulate colorectal cancer cell apoptosis via reduction of mitochondrial membrane potential and generation of reactive oxygen species.	STAT5A STAT5B	2.94e-05	2	189	2	21826656
Pubmed	Immunization of Chlamydia pneumoniae (Cpn)-infected Apob(tm2Sgy)Ldlr(tm1Her)/J mice with a combined peptide of Cpn significantly reduces atherosclerotic lesion development.	APOB LDLR	2.94e-05	2	189	2	24349031
Pubmed	Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.	STAT5A STAT5B	2.94e-05	2	189	2	7720707
Pubmed	Novel mutations identification in exon 4 of LDLR gene in patients with moderate hypercholesterolemia in a Venezuelan population.	APOB LDLR	2.94e-05	2	189	2	20019594
Pubmed	Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice.	APOB LDLR	2.94e-05	2	189	2	22100249
Pubmed	STAT5A and STAT5B have opposite correlations with drug response gene expression.	STAT5A STAT5B	2.94e-05	2	189	2	27264955
Pubmed	Immunotherapy with tolerogenic apolipoprotein B-100-loaded dendritic cells attenuates atherosclerosis in hypercholesterolemic mice.	APOB LDLR	2.94e-05	2	189	2	21357823
Pubmed	Core glycosylation of collagen is initiated by two beta(1-O)galactosyltransferases.	COLGALT2 COLGALT1	2.94e-05	2	189	2	19075007
Pubmed	Catechin prevents severe dyslipidemia-associated changes in wall biomechanics of cerebral arteries in LDLr-/-:hApoB+/+ mice and improves cerebral blood flow.	APOB LDLR	2.94e-05	2	189	2	22268108
Pubmed	Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function.	STAT5A STAT5B	2.94e-05	2	189	2	22159083
Pubmed	STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease.	STAT5A STAT5B	2.94e-05	2	189	2	20008792
Pubmed	STAT5 Regulation of Sex-Dependent Hepatic CpG Methylation at Distal Regulatory Elements Mapping to Sex-Biased Genes.	STAT5A STAT5B	2.94e-05	2	189	2	33199496
Pubmed	Angelman syndrome protein UBE3A interacts with primary microcephaly protein ASPM, localizes to centrosomes and regulates chromosome segregation.	UBE3A ASPM	2.94e-05	2	189	2	21633703
Pubmed	Capillary Dynamics Regulate Post-Ischemic Muscle Damage and Regeneration in Experimental Hindlimb Ischemia.	APOB LDLR	2.94e-05	2	189	2	37626870
Pubmed	Complete deficiency of the low-density lipoprotein receptor is associated with increased apolipoprotein B-100 production.	APOB LDLR	2.94e-05	2	189	2	15637307
Pubmed	Immunization with a combination of 2 peptides derived from the C5a receptor significantly reduces early atherosclerotic lesion in Ldlr(tm1Her) Apob(tm2Sgy) J mice.	APOB LDLR	2.94e-05	2	189	2	22837469
Pubmed	Hypercholesterolemia Induced Immune Response and Inflammation on Progression of Atherosclerosis in Apob(tm2Sgy) Ldlr(tm1Her)/J Mice.	APOB LDLR	2.94e-05	2	189	2	26178198
Pubmed	The influence of STAT5 antisense oligodeoxynucleotides on the proliferation and apoptosis of selected human cutaneous T-cell lymphoma cell lines.	STAT5A STAT5B	2.94e-05	2	189	2	16502315
Interaction	DSCAM interactions	SYNE1 SPTBN1 ZBTB47 VPS54 BICD1 POLR3B DST NF2 SIPA1L1 MACF1 MAP4K4	6.27e-07	171	188	11	int:DSCAM
Cytoband	4q21.23	GPAT3 ABRAXAS1 WDFY3	1.91e-05	13	189	3	4q21.23
Cytoband	1q25	RGSL1 COLGALT2 PLA2G4A	1.67e-04	26	189	3	1q25
Cytoband	19p13.2	LRRC8E PDE4A LDLR ZNF69 HOOK2 DOCK6	3.95e-04	229	189	6	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr17q12	TBC1D3H MMP28 SRCIN1 TBC1D3B TBC1D3G	3.97e-04	149	189	5	chr17q12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	LRRC8E RPL36 PDE4A PDE4C MYO9B COLGALT1 LDLR ZNF69 HOOK2 DOCK6 MAST3	5.07e-04	797	189	11	chr19p13
GeneFamily	PDZ domain containing	SHROOM3 USH1C MAST2 SHROOM2 MAST4 SHANK2 SIPA1L1 SIPA1L2 MAST3	1.03e-06	152	124	9	1220
GeneFamily	Phosphodiesterases	PDE4A PDE4B PDE4C PDE4D	2.01e-05	24	124	4	681
GeneFamily	Collagen beta(1-O)galactosyltransferases	COLGALT2 COLGALT1	4.67e-05	2	124	2	439
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF311 ZBTB20 ZNF577 ZNF652 ZBTB47 ZNF576 CASZ1 ZNF28 ZNF335 ZNF69 ZNF350 ZNF81 ZNF345 ZNF574	4.10e-04	718	124	14	28
GeneFamily	WD repeat domain containing\|Coronins	CORO1B CORO7	9.58e-04	7	124	2	495
GeneFamily	EF-hand domain containing\|Plakins	DST MACF1	1.27e-03	8	124	2	939
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY4 ADCY3	2.03e-03	10	124	2	53
GeneFamily	UPF1 like RNA helicases	HELZ2 DNA2	2.46e-03	11	124	2	1169
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_DN	TLK2 ZBTB20 MYO9B MARK3 DOCK9 GRK5 RNF13 SIK3 MAST2 LDLR SNX13 BICD1 DST TBC1D31 MDN1 UBE3A SIPA1L1 NMT2 MACF1 MPHOSPH9 WDFY3 CRYBG3 NIPBL	6.45e-08	856	189	23	M4500
Coexpression	GSE4590_LARGE_PRE_BCELL_VS_VPREB_POS_LARGE_PRE_BCELL_UP	ZBTB20 DOCK8 ATXN7L1 RNF13 LDLR TBC1D31 SLC12A2 SUSD1 PLA2G4A RNF216	5.80e-07	174	189	10	M6877
Coexpression	GSE13485_DAY7_VS_DAY21_YF17D_VACCINE_PBMC_UP	MARK3 COLGALT1 GTPBP1 LDLR HESX1 SUSD1 USP42 SIPA1L2 CORO7 RUBCN	1.80e-06	197	189	10	M3307
Coexpression	GSE11057_CD4_CENT_MEM_VS_PBMC_UP	TNIK ATXN7L1 DOCK9 XPC STAT5B ITPR3 MDN1 MAST4 ZNF335 DYRK2	1.88e-06	198	189	10	M3116
Coexpression	DESCARTES_ORGANOGENESIS_ENDOTHELIAL_CELLS	ADCY4 MMP28 DOCK9 GRK5 COLGALT2 SHROOM2 ITPR3 MAST4 EXOC3L1 PRKCH DOCK6	4.93e-06	272	189	11	MM3634
Coexpression	BROWNE_HCMV_INFECTION_20HR_DN	PDE4B SYNE1 MAP3K5 DST SIPA1L1 NMT2 MACF1	9.40e-06	102	189	7	M5601
Coexpression	GSE40225_WT_VS_RIP_B7X_DIABETIC_MOUSE_PANCREATIC_CD8_TCELL_UP	DOCK2 AMPD3 COLGALT1 STAT5A ZNF28 SIPA1L1 SHPRH MACF1 RNF216	1.51e-05	199	189	9	M9238
Coexpression	GSE11057_CD4_EFF_MEM_VS_PBMC_UP	ATXN7L1 DOCK9 XPC CCDC57 STAT5B ITPR3 MAST4 NMT2 DYRK2	1.51e-05	199	189	9	M3113
Coexpression	HOLLMANN_APOPTOSIS_VIA_CD40_UP	SYNE1 MAGEH1 COLGALT1 MAST2 GSR ARPC2 DST MAP4K4 RUBCN	1.77e-05	203	189	9	M9695
Coexpression	BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING	LRRC8E PDE4A MYO9B SYNE1 COLGALT1 MAP3K5 STAT5B BICD1 DST NMT2 FGF8 HOOK2 MAST3 CCDC40	2.00e-05	506	189	14	M253
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_XPCS_DN	MYO9B DOCK9 GRK5 BICD1 DST MPHOSPH9	3.54e-05	85	189	6	M10575
Coexpression	LAKE_ADULT_KIDNEY_C29_UNKNOWN_NOVEL_PT_CFH_POS_SUBPOPULATION_S2	SHROOM3 ZBTB20 SYNE1 BICD1 DST MACF1	3.78e-05	86	189	6	M39248
Coexpression	CUI_TCF21_TARGETS_2_DN	SHROOM3 PDE4B PDE4D ATXN7L1 GRK5 MCF2 RNF13 VPS54 SHROOM2 SNX13 DST MAST4 SLC12A2 GVINP1 USP42 MACF1 DAAM2 PRKCH	4.99e-05	854	189	18	M1533
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	RPGRIP1L DOCK8 MYO9B MAST2 BAZ2A SIPA1L1 MACF1 MAP4K4	5.12e-05	180	189	8	M8239
Coexpression	GSE45382_UNTREATED_VS_TGFB_TREATED_MACROPHAGES_DN	TRAF6 PDE4B PDE4D MCF2 PRPF40A LDLR CASZ1 MAP4K4	8.97e-05	195	189	8	M9804
Coexpression	GSE3982_DC_VS_EFF_MEMORY_CD4_TCELL_DN	RPL36 SYNE1 SPTBN1 SIK3 GVINP1 NMT2 PRKCH MPHOSPH9	9.63e-05	197	189	8	M5475
Coexpression	GSE17974_0H_VS_12H_IN_VITRO_ACT_CD4_TCELL_UP	MYO1G PDE4D ZBTB20 SPTBN1 TIGD1 SUSD1 SYTL1 MAP4K4	9.63e-05	197	189	8	M4167
Coexpression	GSE14308_TH2_VS_INDUCED_TREG_UP	RELCH SYNE1 GOSR1 RGS11 ARPC2 SIPA1L1 ASPM MAP4K4	9.97e-05	198	189	8	M3366
Coexpression	GSE19941_UNSTIM_VS_LPS_STIM_IL10_KO_NFKBP50_KO_MACROPHAGE_DN	HNF1A TRPC7 ZBTB20 MAST2 OR51E1 SLC9A3 POLR3B NF2	1.03e-04	199	189	8	M8111
Coexpression	GSE11961_MEMORY_BCELL_DAY7_VS_MEMORY_BCELL_DAY40_UP	COPZ2 RHBDF1 SYNE1 GRK5 SPTBN1 SPTLC1 UBE3A MRPS5	1.03e-04	199	189	8	M9369
Coexpression	GSE2585_CTEC_VS_THYMIC_MACROPHAGE_DN	GCFC2 SLC12A2 NF2 NMT2 MPHOSPH9 WDFY3 DNA2 DYRK3	1.03e-04	199	189	8	M6264
Coexpression	GSE10325_LUPUS_CD4_TCELL_VS_LUPUS_MYELOID_UP	DOCK9 SPTBN1 XPC STAT5B ITPR3 MAST4 PRKCH DYRK2	1.03e-04	199	189	8	M3087
Coexpression	GSE10325_CD4_TCELL_VS_MYELOID_UP	TNIK SYNE1 DOCK9 ASTE1 MAST4 GVINP1 PRKCH DYRK2	1.03e-04	199	189	8	M3078
Coexpression	GSE25123_WT_VS_PPARG_KO_MACROPHAGE_ROSIGLITAZONE_STIM_UP	MAGEH1 MAP7 SNX13 MAP3K5 DST ABCD4 WDFY3 RUBCN	1.07e-04	200	189	8	M7978
Coexpression	GSE3982_DC_VS_CENT_MEMORY_CD4_TCELL_DN	TLK2 RPL36 PDE4B SPTBN1 SIK3 GVINP1 PRKCH DYRK2	1.07e-04	200	189	8	M5477
Coexpression	MULLIGHAN_NPM1_SIGNATURE_3_DN	PDE4B PDE4D LDLR DENND3 UTP11 SIPA1L1 HOOK2	1.74e-04	161	189	7	M15047
Coexpression	IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM	SHROOM3 ZBTB20 DOCK8 DOCK9 MAP7 MAST2 SLC12A2 SRGAP1	1.87e-04	217	189	8	M16407
CoexpressionAtlas	DevelopingKidney_e15.5_Endothelial cells_emap-29977_top-relative-expression-ranked_1000	MYO1G RELCH ADCY4 PDE4B DOCK8 SPTBN1 NAIP ABCC9 CENPS SIK3 SHROOM2 STAT5A STAT5B NF2 SRGAP1 HELZ2 EXOC3L1 PRKCH DNA2 DOCK6 MAP4K4	3.75e-06	764	186	21	DevelopingKidney_e15.5_Endothelial cells_emap-29977_1000
ToppCell	LPS-IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK9 GRK5 BICD1 DST MAST4 MACF1 EXOC3L1 PRKCH SIPA1L2 DOCK6	1.14e-08	194	189	10	0b9cd96fa0b616da7cc90e92ff71157e9bba518f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TNIK SHROOM3 PDE4D SYNE1 DOCK9 MAP7 LDLR CASZ1 MAST4 SHANK2	1.14e-08	194	189	10	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	Control_saline-Endothelial-Endothelial-Gen_Cap\|Control_saline / Treatment groups by lineage, cell group, cell type	ADCY4 PDE4B DOCK9 SPTBN1 DST MACF1 PRKCH SIPA1L2 DOCK6 MAP4K4	1.52e-08	200	189	10	3b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c03-ITGA4\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK PDE4B SPTBN1 CORO1B MAP3K5 STAT5B USP42 MACF1 SYTL1	1.28e-07	190	189	9	91ba66d4b56c59523485b17738e93f14bb00afa4
ToppCell	Fetal_29-31_weeks-Immune-monocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK2 MYO1G PDE4A DOCK8 MYO9B NAIP GPAT3 DENND3 SIPA1L1	1.28e-07	190	189	9	ad297172a74a80ed5c10f921e15efd1da0fd2d6b
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	SHROOM3 PDE4D DOCK9 MAP7 LDLR ITPR3 MAST4 SHANK2 KCNQ3	1.40e-07	192	189	9	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	renal_cortex_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 PDE4D ZBTB20 ATXN7L1 SIK3 MAST4 SHANK2 SIPA1L1 MACF1	1.40e-07	192	189	9	e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TNIK SHROOM3 PDE4D SYNE1 ABCC9 MAP7 LDLR MAST4 KCNQ3	1.47e-07	193	189	9	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	TNIK SHROOM3 PDE4D SYNE1 ABCC9 MAP7 LDLR MAST4 KCNQ3	1.47e-07	193	189	9	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	LPS_IL1RA-Endothelial-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST SLC12A2 MACF1 PRKCH SIPA1L2 DOCK6	1.99e-07	200	189	9	72ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ADCY4 DOCK9 SPTBN1 DST MAST4 MACF1 PRKCH DOCK6 NIPBL	1.99e-07	200	189	9	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCell	LPS_IL1RA-Endothelial\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST SLC12A2 MACF1 PRKCH SIPA1L2 DOCK6	1.99e-07	200	189	9	5c092b2ecc081b5d04476c56333c338cd89ab984
ToppCell	LPS_only-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST MAST4 SLC12A2 MACF1 PRKCH DOCK6	1.99e-07	200	189	9	81e76508c9050d533853d5fd2f3097b27613d836
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 MAP7 LDLR CASZ1 SHANK2 SLC12A2 SRGAP1 HOOK2 SYTL1	1.99e-07	200	189	9	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST SLC12A2 PRKCH SIPA1L2 DOCK6 MAP4K4	1.99e-07	200	189	9	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	LPS_anti-TNF-Endothelial-Endothelial-Gen_Cap\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ADCY4 DOCK9 SPTBN1 DST MAST4 MACF1 PRKCH SIPA1L2 DOCK6	1.99e-07	200	189	9	a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST SLC12A2 PRKCH SIPA1L2 DOCK6 MAP4K4	1.99e-07	200	189	9	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	LPS_only-Endothelial-Endothelial\|LPS_only / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST MAST4 SLC12A2 MACF1 PRKCH DOCK6	1.99e-07	200	189	9	4bb609a284d4e6066f17470a1736076aa4a1f84c
ToppCell	COPD-Epithelial-ATII\|World / Disease state, Lineage and Cell class	SHROOM3 PDE4C SYNE1 ABCC9 LDLR MAST4 SHANK2 KCNQ3	1.19e-06	183	189	8	8e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCell	LA-07._Pericyte\|LA / Chamber and Cluster_Paper	PDE4C GRK5 ABCC9 ADCY3 DENND3 SLC12A2 DAAM2 DOCK6	1.29e-06	185	189	8	ba5baa4d7f097108622674de5b7f4fd279843d24
ToppCell	COVID-19-Epithelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SHROOM3 PDE4D MAP7 LDLR CASZ1 MAST4 SHANK2 KCNQ3	1.46e-06	188	189	8	c9cdee6f8d42ee69f5fb335f25084603c511bd29
ToppCell	COPD-Myeloid-cMonocyte\|Myeloid / Disease state, Lineage and Cell class	PDE4A PDE4B PDE4D NAIP LDLR SRGAP1 SIPA1L1 MAP4K4	1.52e-06	189	189	8	6294691231c7d38707323cf31578a107d3b2c622
ToppCell	COVID-19-Heart-EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	ADCY4 DOCK9 ABCC9 ADCY3 DENND3 SLC12A2 DAAM2 PRKCH	1.58e-06	190	189	8	a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCell	PCW_13-14\|World / Celltypes from embryonic and fetal-stage human lung	TNIK ZBTB20 GRK5 DST MAST4 MACF1 UNC13C CRYBG3	1.58e-06	190	189	8	62a3ec1ae0829602b0569cc051210551644f1d46
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TNIK SHROOM3 PDE4D MAP7 LDLR MAST4 SHANK2 KCNQ3	1.64e-06	191	189	8	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	Adult-Epithelial\|Adult / Lineage, Cell type, age group and donor	SHROOM3 PDE4D DOCK9 MAP7 LDLR MAST4 SHANK2 KCNQ3	1.71e-06	192	189	8	efb962a5fd3b9bdfd8cf8d13c435e29c8271713e
ToppCell	Fetal_29-31_weeks-Immune-alveolar_macrophage_(MARCO_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK2 MYO1G PDE4A DOCK8 MYO9B NAIP GPAT3 SIPA1L1	1.85e-06	194	189	8	3043f6230fa723037c8cf7123f611ae847b39fd4
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 PDE4D SYNE1 MAP7 LDLR MAST4 SHANK2 KCNQ3	1.85e-06	194	189	8	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	COVID-19-kidney-PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ADCY4 DOCK9 SPTBN1 DENND3 MACF1 PRKCH SIPA1L2 DOCK6	1.92e-06	195	189	8	a436483fec137584611f86b7a498a4dc2aa19cd3
ToppCell	Control-Multiplet\|Control / Disease state, Lineage and Cell class	SHROOM3 PDE4D SYNE1 DOCK9 SPTBN1 LDLR MAST4 SHANK2	1.92e-06	195	189	8	618900c80bea09d46dad3f741bd1bff8bf0a64ee
ToppCell	Control-Multiplet-Multiplet\|Control / Disease state, Lineage and Cell class	SHROOM3 PDE4D SYNE1 DOCK9 SPTBN1 LDLR MAST4 SHANK2	1.92e-06	195	189	8	06ac685855e14e4dd2cbe6d0e73f894f2eeff91f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Monocytic\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK2 MYO1G PDE4A DOCK8 NAIP GPAT3 SIPA1L1 PLA2G4A	2.07e-06	197	189	8	1eb9ff8467118b943b5d443cb996168e1e1206b5
ToppCell	LPS_only-Endothelial-Endothelial-Gen_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 MAST4 MACF1 PRKCH SIPA1L2 DOCK6	2.32e-06	200	189	8	eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Mild / Disease, condition lineage and cell class	DOCK9 SPTBN1 STAT5B EIF3CL DST MDN1 MAST4 HELZ2	2.32e-06	200	189	8	d9e8a0d047d4403fb7265fde7448e23a7780785c
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-epithelial_cell_of_lung-Transitional_Club-AT2-Transitional_Club-AT2_L.0.4.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	PDE4C SLC30A8 SIK3 MAP7 LDLR CASZ1 MDN1	1.01e-05	175	189	7	dbd9dac129fb6ae5f55e7b96d04b37585458dc4a
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 GRK5 ABCC9 COLGALT2 ADCY3 MAP3K5 DAAM2	1.08e-05	177	189	7	a8625d14682183cf77cb51eaf11bc15a3528f586
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 GRK5 ABCC9 COLGALT2 ADCY3 MAP3K5 DAAM2	1.08e-05	177	189	7	3645e2f4a48283f290f85c49c3e79e3f58ac9aa6
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GRK5 SPTBN1 HELZ2 FGF8 PRKCH SIPA1L2 DOCK6	1.21e-05	180	189	7	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	SHROOM3 PDE4D SYNE1 ABCC9 LDLR MAST4 KCNQ3	1.21e-05	180	189	7	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	COVID-19-Endothelial_cells-Capillary_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	SYNE1 DOCK9 SPTBN1 SHROOM2 SLC12A2 PRKCH DOCK6	1.25e-05	181	189	7	c5f9c92af1384d9089c65afdf41c6feb8345a3ae
ToppCell	LA-07._Pericyte\|World / Chamber and Cluster_Paper	PDE4C GRK5 ABCC9 ADCY3 DENND3 SLC12A2 DAAM2	1.35e-05	183	189	7	e3835db4795362b0442d5893baf2a78efcc20428
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TNIK PDE4D ABCC9 LDLR MAST4 SHANK2 KCNQ3	1.35e-05	183	189	7	6847c1252d6bb105524f812658112517fd351eab
ToppCell	COVID-19-Epithelial_cells-AT2\|COVID-19 / group, cell type (main and fine annotations)	SHROOM3 PDE4D MAP7 LDLR MAST4 SHANK2 KCNQ3	1.39e-05	184	189	7	369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO9B COLGALT2 PAXBP1 NFE2L1 RUBCN CCDC40	1.43e-05	123	189	6	a45d6907c041ad3f3218cd46dccfc25d4bd961cb
ToppCell	COVID-19-Epithelial_cells-Airway_club\|COVID-19 / group, cell type (main and fine annotations)	SHROOM3 PDE4D DOCK9 MAP7 MAST4 SHANK2 KCNQ3	1.44e-05	185	189	7	cfe6fd73d817e173fe803bc1683c291d9bcb8608
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	GRK5 ABCC9 COLGALT2 ADCY3 DENND3 SLC12A2 DAAM2	1.49e-05	186	189	7	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 MMP28 GRK5 SPTBN1 DENND3 DST SHANK2	1.55e-05	187	189	7	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	Fetal_29-31_weeks-Immune-interstitial_macrophage_(C1Q_positive)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE4B DOCK8 MYO9B NAIP GPAT3 SIPA1L1 RUBCN	1.60e-05	188	189	7	3be2d50148daa4eddddc2c7f269f45c97f7e4931
ToppCell	PCW_13-14-Endothelial-Endothelial_immature-endo_immature_arterial2_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 DENND3 EXOC3L1 PRKCH	1.60e-05	188	189	7	b66f1f08827dd6c48583d871f9f33ea41e48bfb2
ToppCell	COPD-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	PDE4D SYNE1 GRK5 MAST4 SHANK2 ASPM PRKCH	1.60e-05	188	189	7	186fe1ea328c942910190a4240262c0d8642ea3b
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SYNE1 DOCK9 SPTBN1 CASZ1 SLC12A2 PRKCH DOCK6	1.71e-05	190	189	7	0e9847d7f49b2236b8a191e1a7df37556351ba9e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK SHROOM3 PDE4D MAP7 SHANK2 SUSD1 UNC13C	1.77e-05	191	189	7	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRK5 ABCC9 MAP3K5 DST PLA2G4A DAAM2 CRYBG3	1.77e-05	191	189	7	c54c420a94dc749ebc67fc64c5614663f4b9798d
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	SHROOM3 PDE4D MMP28 MAP7 MAST4 SHANK2 KCNQ3	1.77e-05	191	189	7	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRK5 ABCC9 MAP3K5 DST PLA2G4A DAAM2 CRYBG3	1.77e-05	191	189	7	806b94f567ea09a9f443cd4091e70cdb1253ac08
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRK5 ABCC9 MAP3K5 DST PLA2G4A DAAM2 CRYBG3	1.77e-05	191	189	7	cb0aee740b08f7d5fdd2717ecf7429043b277ae7
ToppCell	Control-Multiplet-Multiplet\|World / Disease state, Lineage and Cell class	SHROOM3 PDE4D SYNE1 DOCK9 SPTBN1 MAST4 SHANK2	1.83e-05	192	189	7	1bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCell	RV-08._Macrophage\|World / Chamber and Cluster_Paper	DOCK2 PDE4B DOCK8 NAIP SIPA1L1 ASPM DAAM2	1.83e-05	192	189	7	a1b5dc5beb97a23729b97b54fb4574d10d8fbfb3
ToppCell	RV-08._Macrophage\|RV / Chamber and Cluster_Paper	DOCK2 PDE4B DOCK8 NAIP SIPA1L1 ASPM DAAM2	1.90e-05	193	189	7	12bf98a280f87e4d8f0c6887dfc855da72e47ac1
ToppCell	COVID-19-Endothelial_cells-Inflamed_endothelial_cells\|COVID-19 / group, cell type (main and fine annotations)	ADCY4 SYNE1 DOCK9 SPTBN1 EXOC3L1 PRKCH DOCK6	1.90e-05	193	189	7	979ebefa527f86bebeea5d94e626ee6c1cc7d53b
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	SHROOM3 PDE4D GPAT3 MAP7 CASZ1 MAST4 SHANK2	1.90e-05	193	189	7	82e8a4c40299ffcdfd5a0da711bb9de6fb8a2eaa
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	PDE4B RNF112 SPTBN1 DENND3 PRKCH SIPA1L2 DOCK6	1.90e-05	193	189	7	479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 DENND3 EXOC3L1 PRKCH	1.96e-05	194	189	7	8c88a0ddd61ad900426e312ca4ab13061c0380b8
ToppCell	Control-Myeloid-cMonocyte\|World / Disease state, Lineage and Cell class	PDE4A MYO9B NAIP GPAT3 SIPA1L1 DAAM2 MAP4K4	1.96e-05	194	189	7	f852f5258617a66a4fbd56d64c7b47272e7b8b60
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TNIK SHROOM3 PDE4D ZBTB20 MAP7 MAST4 SHANK2	1.96e-05	194	189	7	7002937e8903e037332a215d00fbc7c7843b33f2
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature4_(5)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	1.96e-05	194	189	7	53a5e8863d79a052dff0758f389be5ac3883c721
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT1\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	SHROOM3 MAP7 PKD1L3 DENND3 PAXBP1 SHANK2	1.97e-05	130	189	6	6434d9106ccb38786dad36fab80163dfc07b6eb7
ToppCell	IPF-Multiplet-Multiplet\|IPF / Disease state, Lineage and Cell class	SHROOM3 PDE4D SYNE1 SPTBN1 CASC2 MAST4 SHANK2	2.03e-05	195	189	7	fce0c29574bb7aab181b9c00feb42681e285d1f2
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Mesenchymal\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	GRK5 ABCC9 ADCY3 MAP3K5 DST PLA2G4A DAAM2	2.03e-05	195	189	7	d8ebb94f30d4a655d6b29dd6a3076be2403d2356
ToppCell	COVID-19-Myeloid-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	DOCK2 PDE4B DOCK8 MYO9B NAIP RNF13 SIPA1L1	2.03e-05	195	189	7	c172c5599379c29123340621a36bfb1fc90c2115
ToppCell	COVID_non-vent-Lymphocytic-T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	TNIK DOCK9 SPTBN1 MAST4 MACF1 PRKCH DYRK2	2.03e-05	195	189	7	4bdedd924564a260841a9153604026b57487c83d
ToppCell	IPF-Multiplet\|IPF / Disease state, Lineage and Cell class	SHROOM3 PDE4D SYNE1 SPTBN1 CASC2 MAST4 SHANK2	2.03e-05	195	189	7	eacc0449ae6f3ad8002268cd061467684c6fb9a7
ToppCell	nucseq-Epithelial\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SHROOM3 PDE4D SYNE1 MAP7 LDLR MAST4 SHANK2	2.03e-05	195	189	7	9406866f99555198a9be311fbd65751b70f35446
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.09e-05	196	189	7	29ed8b1c4cd730db8632fde6eece404f1883a86d
ToppCell	PCW_10-12-Endothelial-Endothelial_immature\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.09e-05	196	189	7	c65b8c7ea34a21897c390e6fb42ee8ca41e9c976
ToppCell	PCW_10-12-Endothelial-Endothelial_mature\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.09e-05	196	189	7	481d79bdaec069ad2746a28d39eeee8d3edf7305
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	PDE4D SYNE1 SPTBN1 MAST4 SHANK2 ASPM MACF1	2.09e-05	196	189	7	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	PDE4D SYNE1 SPTBN1 MAST4 SHANK2 ASPM MACF1	2.09e-05	196	189	7	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature2_(1)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.09e-05	196	189	7	0e8d649b50be2d707510b897bb97767b5847dff9
ToppCell	COVID-19-kidney-VWF+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ADCY4 PDE4B DOCK9 GRK5 PRKCH SIPA1L2 DOCK6	2.09e-05	196	189	7	b71b197cb92117dd9efaa13de000841901cc4ca8
ToppCell	PCW_10-12-Endothelial-Endothelial_immature-endo_immature_venous_(4)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.09e-05	196	189	7	81278e696d823744267d6315c4d42799c4ea0b2c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TNIK PDE4D ZBTB20 SYNE1 DOCK9 PRKCH DYRK2	2.09e-05	196	189	7	c4e7133c609bcbc48c4947ea0aa1a7d9d7251b04
ToppCell	PCW_10-12-Endothelial\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.09e-05	196	189	7	2c60dcf9132ee156f25b349e2ac5313709def4f6
ToppCell	COVID-19-lung-Capillary_1\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADCY4 DOCK9 GRK5 SPTBN1 SHROOM2 PRKCH DOCK6	2.09e-05	196	189	7	ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCell	COVID-19-lung-Capillary_Aerocytes\|lung / Disease (COVID-19 only), tissue and cell type	SYNE1 DOCK9 SPTBN1 SHROOM2 SLC12A2 PRKCH SIPA1L2	2.09e-05	196	189	7	4ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TNIK GRK5 SPTBN1 DST MAST4 MACF1 UNC13C	2.16e-05	197	189	7	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Endothelial-Endothelial_cycling\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.24e-05	198	189	7	eac26ed95b4a4343a5dfe1fbecef9374e5947884
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TNIK SHROOM3 ABCC9 MAP7 MAST4 SHANK2 KCNQ3	2.24e-05	198	189	7	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	COVID-19-lung-Capillary_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ADCY4 DOCK9 GRK5 SPTBN1 EXOC3L1 PRKCH DOCK6	2.24e-05	198	189	7	45419f2804b4be79bae6632e71c54e1af482d115
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	SHROOM3 PDE4D ZBTB20 SIK3 SHANK2 SIPA1L1 WDFY3	2.24e-05	198	189	7	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	wk_15-18-Endothelial-Blood_vessel_endothelial-intermediate_cap\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 EXOC3L1 PRKCH DOCK6	2.24e-05	198	189	7	75270600b5b29187dfa86f01f8f927ae0621cda4
ToppCell	PCW_10-12-Endothelial-Endothelial_cycling-endo_proliferating3_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ADCY4 PDE4B MMP28 DOCK9 BICD1 EXOC3L1 PRKCH	2.24e-05	198	189	7	5fe186d46c47ea1ca450cf67e8eb01c2c3f7f83c
ToppCell	COVID-19-lung-Capillary_2\|lung / Disease (COVID-19 only), tissue and cell type	ADCY4 DOCK9 GRK5 SPTBN1 EXOC3L1 PRKCH DOCK6	2.31e-05	199	189	7	793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TNIK TLK2 RELCH ZBTB20 SYNE1 MACF1 PRKCH	2.31e-05	199	189	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TNIK SHROOM3 PDE4D SYNE1 ABCC9 LDLR ITPR3	2.31e-05	199	189	7	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	LPS_only-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_only / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 MAST4 SLC12A2 HELZ2 MACF1	2.38e-05	200	189	7	edb64556b3fefe3144f73b6efe23b9ffd34091d2
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Artery\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ADCY4 MMP28 DOCK9 DST MAST4 PRKCH DOCK6	2.38e-05	200	189	7	77ae679c35d3b9e2b620f34129f3a8d47e922c65
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST SLC12A2 MACF1 SIPA1L2	2.38e-05	200	189	7	79e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Mesenchymal-BMP_responsible_cell\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	ADCY4 DOCK9 XKR8 DENND3 HELZ2 PLA2G4A DAAM2	2.38e-05	200	189	7	604a88633d4162337e394155c7346dbdef8b9f5a
ToppCell	LPS_anti-TNF-Endothelial\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	PDE4B DOCK9 SPTBN1 DST SLC12A2 PRKCH DOCK6	2.38e-05	200	189	7	1d105eeda5a2c51f9a4654ffc79b7e2348ad593b
Drug	Piclamilast	PDE4A PDE4B PDE4C PDE4D	4.41e-09	4	187	4	DB01791
Drug	Pimethixene maleate [13187-06-9]; Down 200; 9.8uM; MCF7; HT_HG-U133A	MYO9B GOSR1 ASTE1 CRAT CASZ1 SNX13 MAP3K5 STAT5B MAST4 SHANK2 BAZ2A ABCD4 MACF1	8.19e-09	194	187	13	7468_DN
Drug	Ibudilast	PDE4A PDE4B PDE4C PDE4D	2.19e-08	5	187	4	DB05266
Drug	1,7-naphthyridine	PDE4A PDE4B PDE4C PDE4D	2.19e-08	5	187	4	CID000009209
Drug	Ketotifen	PDE4A PDE4B PDE4C PDE4D	1.51e-07	7	187	4	DB00920
Drug	Iloprost	PDE4A PDE4B PDE4C PDE4D	1.51e-07	7	187	4	DB01088
Drug	Dyphylline	PDE4A PDE4B PDE4C PDE4D	3.01e-07	8	187	4	DB00651
Drug	trequinsin	PDE4A PDE4B PDE4C PDE4D	5.38e-07	9	187	4	ctd:C035964
Drug	L-826,141	PDE4A PDE4B PDE4C PDE4D	5.38e-07	9	187	4	ctd:C459562
Drug	4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid	PDE4A PDE4B PDE4D	5.45e-07	3	187	3	DB08299
Drug	Conessine [546-06-5]; Up 200; 11.2uM; PC3; HT_HG-U133A	TNIK PDE4B RPGRIP1L DOCK9 IBSP SPTBN1 MCF2 LDLR ITPR3 MAST4 DAAM2	7.07e-07	196	187	11	4191_UP
Drug	NVP ABE171	PDE4A PDE4B PDE4C PDE4D	8.90e-07	10	187	4	ctd:C451724
Drug	Ro-1724	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 MEP1A ACTR1B	3.58e-06	110	187	8	CID000005087
Drug	motapizone	ADCY4 PDE4A PDE4B PDE4D ADCY3	3.58e-06	29	187	5	CID000065819
Drug	D-22888	PDE4A PDE4B PDE4D	5.39e-06	5	187	3	CID000197714
Drug	alpha-estradiol; Down 200; 0.01uM; PC3; HT_HG-U133A	TRAF6 SYNE1 GRK5 SIK3 MAP3K5 BICD1 BAZ2A RNF216 ZNF574 DYRK2	6.13e-06	199	187	10	1210_DN
Drug	Roflumilast	PDE4A PDE4B PDE4C PDE4D	7.42e-06	16	187	4	ctd:C424423
Drug	zardaverine	ADCY4 PDE4A PDE4B PDE4D ADCY3	9.42e-06	35	187	5	CID000005723
Drug	Cilomilast	PDE4A PDE4B PDE4C PDE4D	1.23e-05	18	187	4	ctd:C433247
Drug	irinotecan HCl; Down 200; 100uM; MCF7; HT_HG-U133A	DOCK9 MAP7 SHROOM2 BICD1 POLR3B MAST4 RNF216 WDFY3 NIPBL	1.43e-05	174	187	9	7530_DN
Drug	AC1L3XQA	ADCY4 PDE4B PDE4D ADCY3	1.55e-05	19	187	4	CID000124009
Drug	papaverine	ADCY4 PDE4A PDE4B PDE4C PDE4D PKD1L3 ADCY3 ITPR3 DST	1.57e-05	176	187	9	CID000004680
Drug	tert-butyl hydroperoxide	DOCK2 AMPD3 MARK3 SPTBN1 SPTLC1 CASP9 SPATA20 CRAT LDLR DENND3 STAT5A GSR MAP3K5 BICD1 NF2 NFE2L1 SIPA1L1 PLA2G4A PRKCH MPHOSPH9 HOOK2	1.77e-05	902	187	21	CID000006410
Drug	Harmine hydrochloride [343-27-1]; Down 200; 16uM; MCF7; HT_HG-U133A	TRAF6 ZNF652 DOCK9 FASTKD2 VPS54 MAP3K5 POLR3B MPHOSPH9 NIPBL	2.14e-05	183	187	9	2750_DN
Drug	Harmine hydrochloride [343-27-1]; Down 200; 16uM; MCF7; HT_HG-U133A	DOCK9 FASTKD2 VPS54 MAP3K5 TBC1D31 SIPA1L1 MPHOSPH9 NIPBL DYRK2	2.33e-05	185	187	9	7209_DN
Drug	AA-2379	PDE4A PDE4B PDE4C PDE4D	2.36e-05	21	187	4	CID000128390
Drug	HWA 153	PDE4A PDE4B PDE4C PDE4D	2.87e-05	22	187	4	CID000162797
Drug	KF18280	PDE4A PDE4B PDE4D	2.96e-05	8	187	3	CID003071941
Drug	Neomycin sulfate [1405-10-3]; Down 200; 4.2uM; MCF7; HT_HG-U133A	PDE4A MYO9B SPTBN1 MAST4 NF2 SIPA1L1 ZNF335 MAST3 DYRK2	3.38e-05	194	187	9	7221_DN
Drug	griseolic acid	PDE4A PDE4B PDE4C PDE4D	3.45e-05	23	187	4	CID000127607
Drug	atherosperminine	PDE4A PDE4B PDE4C PDE4D	3.45e-05	23	187	4	CID000096918
Drug	milrinone	ADCY4 PDE4A PDE4B PDE4C PDE4D SYNE1 ADCY3 MEP1A	3.47e-05	150	187	8	CID000004197
Drug	Isradipine [75695-93-1]; Down 200; 10.8uM; MCF7; HT_HG-U133A	MYO9B GRK5 SPTBN1 BICD1 MAST4 NF2 ZFYVE26 WDFY3 MAST3	3.52e-05	195	187	9	5447_DN
Drug	Levamisole hydrochloride [16595-80-5]; Up 200; 16.6uM; HL60; HG-U133A	GOSR1 LDLR BAZ2A NFE2L1 ZNF335 ASCC2 MACF1 ZNF574 DYRK2	3.52e-05	195	187	9	1410_UP
Drug	Bromperidol [10457-90-6]; Down 200; 9.6uM; HL60; HG-U133A	AMPD3 PDE4D GRK5 MAST2 ADCY3 BICD1 MACF1 ZFYVE26 MPHOSPH9	3.52e-05	195	187	9	1723_DN
Drug	Alfaxalone [23930-19-0]; Down 200; 12uM; HL60; HT_HG-U133A	PDE4A RHBDF1 SPTLC1 VPS54 MAP7 MAST2 SIPA1L1 ZFYVE26 NIPBL	3.52e-05	195	187	9	3135_DN
Drug	Ascorbic acid [50-81-7]; Up 200; 22.4uM; MCF7; HT_HG-U133A	HTR2C MYO9B DOCK9 FASTKD2 STAT5A SNX13 TYRP1 WDFY3 MAST3	3.67e-05	196	187	9	3225_UP
Drug	Lidocaone hydrochloride [73-78-9]; Up 200; 14.8uM; PC3; HT_HG-U133A	ZBTB20 MYO9B IBSP SPTBN1 ITPR3 NF2 BAZ2A MAST3 CCDC40	3.67e-05	196	187	9	4596_UP
Drug	Stachydrine hydrochloride; Down 200; 22.2uM; PC3; HT_HG-U133A	TRAF6 SYNE1 GRK5 FASTKD2 COLGALT2 MAP7 DENND3 SHANK2 ZNF350	3.67e-05	196	187	9	4469_DN
Drug	Pentylenetetrazole [54-95-5]; Down 200; 29uM; PC3; HT_HG-U133A	MYO9B ASTE1 DENND3 GSR MAST4 NF2 RNF216 PRKCH DOCK6	3.82e-05	197	187	9	2092_DN
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	XPC VPS54 CRAT ADCY3 ITPR3 NF2 UBE3A ZNF335 DNA2	3.82e-05	197	187	9	6984_DN
Drug	Dexamethasone acetate [1177-87-3]; Up 200; 9.2uM; MCF7; HT_HG-U133A	AMPD3 MYO9B GOSR1 CASP9 MAP3K5 SHANK2 NF2 ZNF574 DYRK3	3.82e-05	197	187	9	6271_UP
Drug	Ifenprodil tartrate [23210-58-4]; Down 200; 8.4uM; PC3; HT_HG-U133A	MYO9B MAP7 SNX13 DHX30 NF2 BAZ2A RNF216 ZNF350 MAST3	3.82e-05	197	187	9	5044_DN
Drug	Avermectin B1 [71751-41-2]; Down 200; 4.8uM; MCF7; HT_HG-U133A	ZNF652 SPTBN1 CASP9 VPS54 MAP3K5 BICD1 NMT2 MAP4K4 DYRK2	3.97e-05	198	187	9	7218_DN
Drug	Tobramycin [32986-56-4]; Up 200; 8.6uM; HL60; HT_HG-U133A	PDE4D ZBTB20 COPZ2 RHBDF1 MAGEH1 SHANK2 NF2 SIPA1L1 KCNQ3	4.29e-05	200	187	9	2481_UP
Drug	Azaguanine-8 [134-58-7]; Up 200; 26.2uM; MCF7; HT_HG-U133A	PDE4B PDE4C ATXN7L1 FASTKD2 STAT5B ITPR3 NMT2 DYRK3 CCDC40	4.29e-05	200	187	9	7444_UP
Drug	PDEs	ADCY4 PDE4A PDE4B PDE4C PDE4D ADCY3 MEP1A	4.94e-05	116	187	7	CID003036959
Drug	AC1LD7MJ	PDE4B PDE4C PDE4D HTR2C SYNE1	5.04e-05	49	187	5	CID000643628
Drug	desethyl KBT-3022	PDE4A PDE4B PDE4C PDE4D	5.72e-05	26	187	4	CID000127736
Drug	T-440	PDE4A PDE4B PDE4C PDE4D	5.72e-05	26	187	4	CID000177965
Drug	Ro 15-2041	PDE4A PDE4B PDE4C PDE4D	5.72e-05	26	187	4	CID000132434
Drug	cilostamide	ADCY4 PDE4A PDE4B PDE4C PDE4D LDLR ADCY3	6.13e-05	120	187	7	CID000002753
Drug	V11294 Analogue 5f	PDE4B PDE4D	6.71e-05	2	187	2	CID011214587
Drug	V11294 Analogue 5t	PDE4B PDE4D	6.71e-05	2	187	2	CID011226695
Drug	V11294 Analogue 5e	PDE4B PDE4D	6.71e-05	2	187	2	CID011443441
Drug	V11294 Analogue 5n	PDE4B PDE4D	6.71e-05	2	187	2	CID011238279
Drug	V11294 Analogue 5p	PDE4B PDE4D	6.71e-05	2	187	2	CID011478659
Drug	V11294 Analogue 5o	PDE4B PDE4D	6.71e-05	2	187	2	CID011249748
Drug	V11294 Analogue 5c	PDE4B PDE4D	6.71e-05	2	187	2	CID011179896
Drug	V11294 Analogue 5b	PDE4B PDE4D	6.71e-05	2	187	2	CID011443760
Drug	Cis-4-Cyano-4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]Cyclohexanecarboxylic Acid	PDE4B PDE4D	6.71e-05	2	187	2	DB03849
Drug	T-2585.HCl	PDE4B PDE4D	6.71e-05	2	187	2	CID006918355
Drug	V11294 Analogue 5m	PDE4B PDE4D	6.71e-05	2	187	2	CID011477773
Drug	V11294 Analogue 8a	PDE4B PDE4D	6.71e-05	2	187	2	CID011442865
Drug	V11294 Analogue 5q	PDE4B PDE4D	6.71e-05	2	187	2	CID011318772
Drug	V11294 Analogue 5h	PDE4B PDE4D	6.71e-05	2	187	2	CID011306698
Drug	3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester	PDE4B PDE4D	6.71e-05	2	187	2	DB01959
Drug	4-[3-(Cyclopentyloxy)-4-Methoxyphenyl]-2-Pyrrolidinone	PDE4B PDE4D	6.71e-05	2	187	2	DB01954
Drug	M 98	PDE4B PDE4D	6.71e-05	2	187	2	CID006420180
Drug	V11294 Analogue 5i	PDE4B PDE4D	6.71e-05	2	187	2	CID011376249
Drug	V11294 Analogue 5d	PDE4B PDE4D	6.71e-05	2	187	2	CID011283750
Drug	3-cyclopentyloxy-4-methoxybenzoic acid	PDE4B PDE4D	6.71e-05	2	187	2	CID002779323
Drug	V11294 Analogue 5v	PDE4B PDE4D	6.71e-05	2	187	2	CID011375325
Drug	3-cyclopentyloxy-4-methoxybenzaldehyde	PDE4B PDE4D	6.71e-05	2	187	2	CID002735893
Drug	Np-V	PDE4B PDE4D	6.71e-05	2	187	2	CID009999276
Drug	(S)-Rolipram	PDE4B PDE4D	6.71e-05	2	187	2	DB03606
Drug	1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester	PDE4B PDE4D	6.71e-05	2	187	2	ctd:C554440
Drug	V11294 Analogue 5r	PDE4B PDE4D	6.71e-05	2	187	2	CID011168555
Drug	V11294 Analogue 5j	PDE4B PDE4D	6.71e-05	2	187	2	CID011433797
Drug	V11294 Analogue 5a	PDE4B PDE4D	6.71e-05	2	187	2	CID011386897
Drug	V11294 Analogue 5k	PDE4B PDE4D	6.71e-05	2	187	2	CID011456440
Drug	(R)-Rolipram	PDE4B PDE4D	6.71e-05	2	187	2	DB04149
Drug	(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one	PDE4A PDE4D	6.71e-05	2	187	2	DB06842
Drug	fullerene C60	RPL36 SHROOM3 TRAF6 PDE4C PDE4D ZBTB20 MYO9B MMP28 SYNE1 GOSR1 ZBTB47 RNF13 TNIP1 SPATA20 RGS11 SRCIN1 MAST2 CRAT DENND3 BICD1 ARPC2 ITPR3 BAZ2A HELZ2 EXOC3L1 ZNF574 DYRK2	9.80e-05	1498	187	27	ctd:C069837
Drug	tocopherol	CASP9 APOB LDLR GSR POLR3B PRKCH	1.06e-04	91	187	6	CID000014986
Drug	trequinsin	ADCY4 PDE4B PDE4C PDE4D ADCY3	1.14e-04	58	187	5	CID000005537
Drug	imidazole-4-carboxamide	PDE4A PDE4B PDE4C PDE4D	1.32e-04	32	187	4	CID000152917
Drug	Parthenolide [20554-84-1]; Up 200; 16.2uM; MCF7; HT_HG-U133A	TNIK CASP9 XPC CCDC57 LDLR BAZ2A ZNF335 WDFY3	1.46e-04	184	187	8	5530_UP
Drug	Tribenoside [10310-32-4]; Up 200; 8.4uM; HL60; HT_HG-U133A	TNIK PDE4B ZBTB20 CASZ1 SHANK2 SIPA1L1 ABCD4 ZNF345	1.46e-04	184	187	8	2946_UP
Drug	1,3-indandione	PDE4B PDE4D CENPS	1.47e-04	13	187	3	CID000011815
Drug	ibudilast	PDE4A PDE4B PDE4D GSR	1.50e-04	33	187	4	CID000003671
Drug	dyphylline	PDE4A PDE4B PDE4C PDE4D	1.50e-04	33	187	4	CID000003182
Drug	trichostatin A, Streptomyces sp.; Up 200; 1uM; MCF7; HT_HG-U133A	PDE4A RPGRIP1L GRK5 DENND3 NMT2 NME7 MAST3 DYRK3	1.63e-04	187	187	8	5976_UP
Drug	Ketoconazole [65277-42-1]; Up 200; 7.6uM; HL60; HT_HG-U133A	PDE4B ZNF576 SPATA20 ADCY3 NF2 SIPA1L1 RNF216 ZNF574	1.75e-04	189	187	8	1285_UP
Drug	Gramine [87-52-5]; Up 200; 23uM; HL60; HT_HG-U133A	TNIK PDE4A GCFC2 ZBTB20 CCDC57 NF2 NMT2 DYRK3	1.81e-04	190	187	8	2143_UP
Drug	PF-00562151-00 [351320-12-2]; Down 200; 10uM; PC3; HT_HG-U133A	DOCK9 SPTBN1 MAP7 MAST2 LDLR NF2 PRKCH DOCK6	1.95e-04	192	187	8	5959_DN
Drug	BW A78U	PDE4B PDE4D	2.00e-04	3	187	2	CID000127779
Drug	Enprofylline	PDE4A PDE4B	2.00e-04	3	187	2	DB00824
Drug	Org 4428	PDE4B PDE4D	2.00e-04	3	187	2	CID000166560
Drug	1-Pyrrolidinebutanenitrile	PDE4B PDE4D	2.00e-04	3	187	2	CID000118838
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	HNF1A AMPD3 APOB SIK3 SNX13 MACF1	3.59e-06	67	181	6	EFO_0008595, EFO_0020946
Disease	LDL cholesterol change measurement	APOB PKD1L3 LDLR	7.80e-06	7	181	3	EFO_0007804
Disease	phospholipids in medium HDL measurement	HNF1A APOB SIK3 LDLR DOCK6	2.23e-05	55	181	5	EFO_0022295
Disease	omega-6 polyunsaturated fatty acid measurement	ZNF311 HNF1A GCFC2 APOB SIK3 LDLR ZNF335 DOCK6	3.12e-05	197	181	8	EFO_0005680
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	HNF1A APOB SIK3 LDLR SNX13 MACF1	4.28e-05	103	181	6	EFO_0008595, EFO_0020944
Disease	myocardial infarction	HNF1A SHROOM3 ZNF652 DOCK9 RNF13 APOB PKD1L3 LDLR NME7 ARMH4	6.53e-05	350	181	10	EFO_0000612
Disease	phospholipids:total lipids ratio	HNF1A APOB SIK3 LDLR SNX13 ZNF335 MACF1 DOCK6	8.47e-05	227	181	8	EFO_0020946
Disease	cholesterol:total lipids ratio, intermediate density lipoprotein measurement	HNF1A SHROOM3 APOB LDLR SNX13 MACF1	1.05e-04	121	181	6	EFO_0008595, EFO_0020943
Disease	major depressive disorder (implicated_via_orthology)	HTR2C ADCY3	1.12e-04	3	181	2	DOID:1470 (implicated_via_orthology)
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	HNF1A APOB SIK3 LDLR SNX13 MACF1 DOCK6 RAI1	1.36e-04	243	181	8	EFO_0004612, EFO_0020944
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	HNF1A SHROOM3 APOB LDLR SNX13 MACF1	1.37e-04	127	181	6	EFO_0008595, EFO_0020947
Disease	Inborn Errors of Metabolism	ITPA ABCD4 PLA2G4A	1.45e-04	17	181	3	C0025521
Disease	coronary artery disease	HNF1A SHROOM3 ZBTB20 DOCK8 MYO9B MARK3 ZNF652 DOCK9 APOB PKD1L3 LDLR SNX13 KIAA0319 MAST4 ZNF335 CORO7 NME7 DOCK6 RAI1	1.46e-04	1194	181	19	EFO_0001645
Disease	linoleic acid measurement	ZNF311 APOB SIK3 LDLR MAST4 ZNF335 DOCK6	1.58e-04	186	181	7	EFO_0006807
Disease	saturated fatty acids measurement	HNF1A APOB SIK3 LDLR	1.68e-04	45	181	4	EFO_0022304
Disease	lipid measurement, high density lipoprotein cholesterol measurement	ZNF311 HNF1A AMPD3 APOB SIK3 LDLR DOCK6 RAI1 ARMH4	2.14e-04	330	181	9	EFO_0004529, EFO_0004612
Disease	total lipids in lipoprotein particles measurement	HNF1A APOB LDLR DOCK6	2.16e-04	48	181	4	EFO_0022309
Disease	TYPE 1 DIABETES MELLITUS	HNF1A ITPR3	2.23e-04	4	181	2	222100
Disease	Diabetes mellitus type 1	HNF1A ITPR3	2.23e-04	4	181	2	cv:C0011854
Disease	lipid measurement, lipoprotein measurement	HNF1A APOB SIK3 LDLR DOCK6	2.37e-04	90	181	5	EFO_0004529, EFO_0004732
Disease	coagulation factor V measurement	MAST4 SUSD1 NME7	2.40e-04	20	181	3	EFO_0008087
Disease	obsolete_red blood cell distribution width	HNF1A RPL36 DOCK8 MYO9B MARK3 APOB SIK3 CRAT SNX13 ARPC2 MAST4 SLC12A2 SUSD1 NFE2L1 FAM222B HELZ2 HOOK2 DOCK6 MAST3 ARMH4	2.43e-04	1347	181	20	EFO_0005192
Disease	sleep duration, low density lipoprotein cholesterol measurement	HNF1A APOB PKD1L3 LDLR SNX13	2.49e-04	91	181	5	EFO_0004611, EFO_0005271
Disease	cholesterol:total lipids ratio, low density lipoprotein cholesterol measurement	HNF1A APOB SIK3 LDLR SNX13 MACF1	2.71e-04	144	181	6	EFO_0004611, EFO_0020943
Disease	phospholipids in very small VLDL measurement	HNF1A APOB SIK3 LDLR	2.73e-04	51	181	4	EFO_0022300
Disease	level of Phosphatidylinositol (18:0_18:2) in blood serum	HNF1A SIK3 DOCK6	2.78e-04	21	181	3	OBA_2045156
Disease	reticulocyte measurement	AMPD3 ZBTB20 MYO9B MMP28 ZC3H11B ADCY3 DENND3 SNX13 MAP3K5 KLHL11 SLC12A2 SUSD1 USP42 ASCC2 HOOK2 CORO7 ARMH4	2.80e-04	1053	181	17	EFO_0010700
Disease	triglycerides:total lipids ratio, low density lipoprotein cholesterol measurement	HNF1A SHROOM3 APOB LDLR SNX13 MACF1	3.38e-04	150	181	6	EFO_0004611, EFO_0020947
Disease	Malignant neoplasm of breast	SYNE1 IBSP SPTLC1 TNIP1 COLGALT2 JAKMIP3 SIK3 SHROOM2 STAT5A NF2 ABRAXAS1 SIPA1L1 PLA2G4A MACF1 EXOC3L1 ZFYVE26 NIPBL	3.51e-04	1074	181	17	C0006142
Disease	hereditary sensory neuropathy (implicated_via_orthology)	SPTLC1 DST	3.70e-04	5	181	2	DOID:0050548 (implicated_via_orthology)
Disease	cerebellar ataxia (is_implicated_in)	RPGRIP1L SYNE1	3.70e-04	5	181	2	DOID:0050753 (is_implicated_in)
Disease	Coronary heart disease	HNF1A APOB LDLR	4.18e-04	24	181	3	C0010068
Disease	triglycerides in IDL measurement	HNF1A APOB SIK3 LDLR	4.49e-04	58	181	4	EFO_0022149
Disease	total lipids in medium HDL measurement	HNF1A APOB SIK3 DOCK6	4.49e-04	58	181	4	EFO_0022310
Disease	free cholesterol in medium HDL measurement	HNF1A APOB SIK3 DOCK6	4.49e-04	58	181	4	EFO_0022267
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	HNF1A APOB SIK3 LDLR SNX13 HELZ2 MACF1 DOCK6	4.56e-04	291	181	8	EFO_0008317, EFO_0020946
Disease	cholesterol in medium HDL measurement	HNF1A APOB SIK3 DOCK6	4.79e-04	59	181	4	EFO_0021903
Disease	triglyceride measurement, very low density lipoprotein cholesterol measurement	HNF1A SHROOM3 ZC3H11B APOB LDLR ZNF335 MACF1	4.87e-04	224	181	7	EFO_0004530, EFO_0008317
Disease	cholesterol to total lipids in IDL percentage	APOB SIK3 LDLR MACF1	5.11e-04	60	181	4	EFO_0022233
Disease	Edema	CASP9 GSR SLC9A3	5.32e-04	26	181	3	C0013604
Disease	level of Sterol ester (27:1/18:2) in blood serum	HNF1A APOB LDLR	5.32e-04	26	181	3	OBA_2045194
Disease	level of Sterol ester (27:1/16:0) in blood serum	HNF1A APOB LDLR	5.32e-04	26	181	3	OBA_2045191
Disease	Anasarca	CASP9 GSR SLC9A3	5.32e-04	26	181	3	C0151603
Disease	free cholesterol in HDL measurement	HNF1A APOB SIK3 DOCK6	5.44e-04	61	181	4	EFO_0022264
Disease	phospholipids in HDL measurement	HNF1A APOB SIK3 DOCK6	5.44e-04	61	181	4	EFO_0022293
Disease	venous thromboembolism	RGSL1 ATXN7L1 GRK5 FASTKD2 ITPR3 SUSD1 PRKCH MPHOSPH9 NME7 ARMH4	5.82e-04	460	181	10	EFO_0004286
Disease	coronary artery disease, plasminogen activator inhibitor 1 measurement	HNF1A APOB LDLR NME7	6.15e-04	63	181	4	EFO_0001645, EFO_0004792
Disease	total lipids in HDL measurement	HNF1A APOB SIK3 DOCK6	6.15e-04	63	181	4	EFO_0022307
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	HNF1A APOB SIK3 PKD1L3 LDLR SNX13 MACF1 DOCK6	6.48e-04	307	181	8	EFO_0004612, EFO_0020946
Disease	pancreatic carcinoma	HNF1A MARK3 APOB BICD1 DST SRGAP1	7.40e-04	174	181	6	EFO_0002618
Disease	serum metabolite measurement	TNIK HNF1A RGSL1 TRIM4 CYP3A43 CASP9 CCDC81 APOB TECRL CRAT LDLR SLC9A3 PLA2G4A DOCK6 ARMH4	7.63e-04	945	181	15	EFO_0005653
Disease	Bipolar Disorder	PDE4A PDE4B TRPC7 HTR2C SYNE1 DOCK9 ADCY3 SHANK2 PLA2G4A KCNQ3	7.69e-04	477	181	10	C0005586
Disease	platelet component distribution width	MYO1G DOCK8 MYO9B MARK3 SYNE1 DOCK9 GRK5 ARPC2 BAZ2A NFE2L1 MACF1 HOOK2 CCDC40	8.25e-04	755	181	13	EFO_0007984
Disease	immature platelet measurement	MYO1G DOCK8 MYO9B ARPC2 BAZ2A	8.54e-04	119	181	5	EFO_0803541
Disease	tissue plasminogen activator measurement, coronary artery disease	HNF1A APOB LDLR NME7	9.66e-04	71	181	4	EFO_0001645, EFO_0004791
Disease	HbA1c measurement	TNIK ZNF311 HNF1A AMPD3 MYO9B SLC30A8 ZC3H11B RGS11 ASCC2 MACF1 HOOK2 RAI1	9.93e-04	675	181	12	EFO_0004541
Disease	marginal zone B-cell lymphoma	APOB PRKCH	1.02e-03	8	181	2	EFO_1000630
Disease	Familial hypercholesterolemia	APOB LDLR	1.02e-03	8	181	2	cv:C0020445
Disease	sensorineural hearing loss (biomarker_via_orthology)	SLC12A2 KCNJ10	1.02e-03	8	181	2	DOID:10003 (biomarker_via_orthology)
Disease	free cholesterol to total lipids in large LDL percentage	APOB SIK3 LDLR MACF1	1.13e-03	74	181	4	EFO_0022280
Disease	HMG CoA reductase inhibitor use measurement	HNF1A APOB LDLR ITPR3 FAM222B DOCK6	1.13e-03	189	181	6	EFO_0009932
Disease	Parkinsonism (biomarker_via_orthology)	CASP9 ABCC9 GSR	1.18e-03	34	181	3	DOID:0080855 (biomarker_via_orthology)
Disease	chylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	APOB SIK3 MAST3	1.18e-03	34	181	3	EFO_0008317, EFO_0008596, EFO_0020947
Disease	esterified cholesterol measurement	HNF1A APOB SIK3 LDLR DOCK6	1.18e-03	128	181	5	EFO_0008589
Disease	choline measurement	HNF1A APOB SIK3 LDLR DOCK6	1.27e-03	130	181	5	EFO_0010116
Disease	polyunsaturated fatty acid measurement	HNF1A APOB SIK3 LDLR DOCK6	1.31e-03	131	181	5	EFO_0010733
Disease	Cardiovascular Diseases	GRK5 APOB SLC12A2	1.40e-03	36	181	3	C0007222
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	SHROOM3 APOB SIK3 LDLR SNX13 MACF1	1.51e-03	200	181	6	EFO_0004611, EFO_0020945
Disease	Reactive hypoglycemia	HNF1A GSR	1.63e-03	10	181	2	C0271710
Disease	Fasting Hypoglycemia	HNF1A GSR	1.63e-03	10	181	2	C0271708
Disease	familial hypercholesterolemia (is_implicated_in)	APOB LDLR	1.63e-03	10	181	2	DOID:13810 (is_implicated_in)
Disease	level of Triacylglycerol (51:3) in blood serum	APOB SIK3	1.63e-03	10	181	2	OBA_2045163
Disease	cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	HNF1A APOB SIK3 LDLR SNX13 MACF1 DOCK6	1.64e-03	276	181	7	EFO_0004612, EFO_0020943
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	HNF1A APOB SIK3 SNX13 STAT5B RAI1	1.76e-03	206	181	6	EFO_0004612, EFO_0020947
Disease	Intellectual Disability	TLK2 DOCK8 SYNE1 RNF13 POLR3B SHANK2 ZNF335 MACF1 RAI1	1.85e-03	447	181	9	C3714756
Disease	platelet-to-lymphocyte ratio	MYO1G PDE4A GRK5 SIK3 ARPC2 ITPR3 BAZ2A RAI1	1.88e-03	363	181	8	EFO_0008446
Disease	lipoprotein measurement, phospholipid measurement	HNF1A APOB LDLR DOCK6	1.88e-03	85	181	4	EFO_0004639, EFO_0004732
Disease	cholesterol in very small VLDL measurement	HNF1A APOB LDLR	1.90e-03	40	181	3	EFO_0022231
Disease	liver fibrosis measurement	HNF1A APOB LDLR ITPR3	1.97e-03	86	181	4	EFO_0010576
Disease	Hypoglycemia	HNF1A GSR	1.98e-03	11	181	2	C0020615
Disease	beta thalassemia (is_marker_for)	APOB GSR	1.98e-03	11	181	2	DOID:12241 (is_marker_for)
Disease	level of Diacylglycerol (18:1_18:1) in blood serum	APOB SIK3	1.98e-03	11	181	2	OBA_2045170
Disease	Basal cell carcinoma	XPC STAT5B	1.98e-03	11	181	2	C0007117
Disease	Combined immunodeficiency	DOCK8 STAT5A STAT5B	2.04e-03	41	181	3	C0494261
Disease	triglycerides in large LDL measurement	APOB SIK3 LDLR	2.34e-03	43	181	3	EFO_0022319
Disease	cholesteryl esters to total lipids in small HDL percentage	HNF1A APOB SIK3	2.34e-03	43	181	3	EFO_0022254
Disease	free cholesterol to total lipids in very small VLDL percentage	APOB SIK3 LDLR	2.34e-03	43	181	3	EFO_0022290
Disease	Emery-Dreifuss muscular dystrophy (implicated_via_orthology)	SYNE1 HOOK2	2.37e-03	12	181	2	DOID:11726 (implicated_via_orthology)
Disease	Charcot-Marie-Tooth disease (is_implicated_in)	ITPR3 POLR3B	2.37e-03	12	181	2	DOID:10595 (is_implicated_in)
Disease	Abnormality of the dentition	SPTLC1 UNC13C	2.37e-03	12	181	2	HP_0000164
Disease	level of Ceramide (d42:2) in blood serum	HNF1A APOB	2.37e-03	12	181	2	OBA_2045186
Disease	autism spectrum disorder (implicated_via_orthology)	HTR2C ITPR3 SHANK2 UBE3A WDFY3	2.52e-03	152	181	5	DOID:0060041 (implicated_via_orthology)
Disease	very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio	SHROOM3 APOB LDLR ZNF335 HELZ2 MACF1	2.56e-03	222	181	6	EFO_0008317, EFO_0020943
Disease	total lipids in very small VLDL measurement	HNF1A APOB LDLR	2.67e-03	45	181	3	EFO_0022156
Disease	fibrinogen measurement, tissue plasminogen activator measurement	HNF1A PKD1L3 SNX13	2.67e-03	45	181	3	EFO_0004623, EFO_0004791
Disease	fibrinogen measurement, plasminogen activator inhibitor 1 measurement	HNF1A PKD1L3 SNX13	2.67e-03	45	181	3	EFO_0004623, EFO_0004792
Disease	triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement	HNF1A APOB LDLR ZNF335 HELZ2 MACF1	2.73e-03	225	181	6	EFO_0008317, EFO_0020947
Disease	Anemia, Hemolytic, Acquired	ITPA GSR	2.79e-03	13	181	2	C0002879
Disease	Anemia, Hemolytic	ITPA GSR	2.79e-03	13	181	2	C0002878
Disease	Anemia, Microangiopathic	ITPA GSR	2.79e-03	13	181	2	C0002889

Protein segments in the cluster

Peptide	Gene	Start	Entry
MDRKVAREFRHKVDF	USH1C	1	Q9Y6N9
KFRRHSDQIMTFRER	ABRAXAS1	101	Q6UWZ7
LRKLFSHNMTRLRKF	NAIP	611	Q13075
ALIRFSRDHFRGKSM	EXOC3L1	466	Q86VI1
SRDQPFIKKMHFTIR	CDY1	261	Q9Y6F8
FAKDLEMFARHAKRT	CENPS	61	Q8N2Z9
MSEFIQGHRLSKEKR	BICD1	901	Q96G01
MSHKRLDDRVKTHLF	CRYBG3	1431	Q68DQ2
KKRDNSLQHGFMRFS	CASZ1	516	Q86V15
KMIANDVHTLRRSKA	APOL4	241	Q9BPW4
RQLFFRKKLLHSSQM	BAZ2A	1096	Q9UIF9
QKRLHRSVFLTFLRM	ASCC2	116	Q9H1I8
FKRHKRKQREFNSMQ	ARMH4	746	Q86TY3
MRAKTSDFLKVLNRA	ARPC2	266	O15144
FESLNHMLRKNVEKR	COPZ2	131	Q9P299
IRHDKVLRSFDSMIS	GSR	261	P00390
ENFKEMHRAFKRAND	GVINP1	2041	Q7Z2Y8
NFLSIAVKSIHRKRM	GTPBP1	436	O00178
EHSRFNSRTKAIMKI	HTR2C	161	P28335
FAIHKSDMDLRRTLF	ACTR1B	281	P42025
MSFRKVVRQSKFRHV	CORO1B	1	Q9BR76
HKALMERALRATFRE	ADCY4	191	Q8NFM4
LMKASSRFKAHQDAL	CRAT	21	P43155
RAFRHETRFKQRMLE	ABCC9	1186	O60706
EKLEGDFRFKHMQIR	ABCD4	216	O14678
MFSLDSFRKDRAQHR	DHX30	1	Q7L2E3
HSFLKARLNRRMDAF	DENND3	411	A2RUS2
REHQAALKIQSAFRM	ASPM	1896	Q8IZT6
LQAAFRGMKTRRHLK	ASPM	2391	Q8IZT6
TLKDRAREKIQMAHS	ASTE1	91	Q2TB18
DRFRFALNSMVEKHL	ATXN7L1	486	Q9ULK2
RRLNFLESKFSLHEM	AMPD3	276	Q01432
FLDKQMSRDEHRARA	NFE2L1	606	Q14494
HRARAMKIPFTNDKI	NFE2L1	616	Q14494
DRPLHALKRKSAFMA	RAI1	1216	Q7Z5J4
VDRNEGLKFARKHSM	RAB18	131	Q9NP72
RVLMTKSADFHKREI	RGS11	216	O94810
KSERFFKVLHDRMKR	ITPR3	1781	Q14573
FKVLHDRMKRAQQET	ITPR3	1786	Q14573
RRLKSEMDFLKNEHF	RELCH	381	Q9P260
LNEARDKFAKALMHF	DAAM2	931	Q86T65
LDGVFMHKRAQRLKF	MAP4K4	1191	O95819
KKLRESVLRMSFEFH	MDN1	2656	Q9NU22
EFHKTKANFMAIRER	GOSR1	121	O95249
SSKLKVMHFVARVRN	MAGEH1	171	Q9H213
KAAHSRNSMDRPKLF	MAP7	261	Q14244
FAEIMKDHLANRRKE	nan	326	A8MVJ9
RSNVRMEHIADKRFL	KCNJ10	36	P78508
RKLVEVKFSHLSRNM	NMT2	306	O60551
SLEKQLHSMKFSERR	RPGRIP1L	326	Q68CZ1
NHKKSRVMDFFRRID	DST	7196	Q03001
RIRHLEMDFEKSRSQ	HOOK2	641	Q96ED9
LNNKERFRTAFRMKA	KCNQ3	466	O43525
MNRFRVSKFRHTEAR	CORO7	1	P57737
AAVLHMRSTEARKKA	OR2T8	221	A6NH00
FIGLSMVHRFSKRRD	OR51E1	256	Q8TCB6
KFKRMLNRELTHLSE	PDE4A	261	P27815
ASNKFKRMLNRELTH	PDE4B	246	Q07343
RHSVGEMASNKFKRI	PDE4C	226	Q08493
NKFKRMLNRELTHLS	PDE4D	306	Q08499
FREQSLAMLSKAHRA	FAM222B	526	Q8WU58
IMHRAENRKKFLRSI	NIPBL	1716	Q6KC79
AKLKRSHRESQFLMA	HESX1	161	Q9UBX0
RMTLKKFHVLRTSAN	MPHOSPH9	1016	Q99550
ERAFSLRKAHSIKDM	NAXD	36	Q8IW45
SKLGVHDMNDRKRLF	KIF24	41	Q5T7B8
LSHALRRMENKLKFV	JAKMIP3	351	Q5VZ66
RKRSNHRRMKSDSFL	KIAA0408	186	Q6ZU52
RRKEEAFRHKLAMDT	HNF1A	271	P20823
RTLSEKARDDMKRHS	NLRP5	136	P59047
FSLQVFLRDHLKVMR	LRRC8E	476	Q6NSJ5
AAVLHMRSTEARKKA	OR2T33	221	Q8NG76
DAAFIHAARKKRQMA	PAXBP1	221	Q9Y5B6
HKKSRVMDFFRRIDK	MACF1	7041	Q9UPN3
IGNHDLFMRRRKADS	NF2	301	P35240
ESERKRIFKDFMHVL	PRPF40A	786	O75400
SKTRQHQREVHFMKR	FGF8	181	P55075
AHESDARRRMISKQF	EIF3CL	701	B5ME19
AHMKAKFRETLEDTR	APOB	2506	P04114
ALKAADMIRRNFHKV	KLHL11	221	Q9NVR0
RGFITHKFRERLMRK	BCLAF3	686	A2AJT9
AESDLKRLSRKHEFM	DOCK2	1716	Q92608
KRLSRKHEFMSDTNL	DOCK2	1721	Q92608
MAASERRAFAHKINR	DOCK6	1	Q96HP0
QRAFDSIVNKDHKRM	DOCK8	1776	Q8NF50
SVTMRSFKRRFFHLI	DOCK9	191	Q9BZ29
THFLKNSIERMKESR	CYP3A43	246	Q9HB55
TFMKRRQDELKHEST	GCFC2	361	P16383
FERSEMKDRHLVTKR	GPAT3	271	Q53EU6
ALFRHQMKSLATREQ	CCDC81	366	Q6ZN84
DIKRMKHFGSALRLR	CASC2	51	Q6XLA1
RRRFSSLHFMVEVKG	CASP9	191	P55211
MDRKALTRTDFHHKQ	CCDC40	981	Q4G0X9
MADQLLRKKRRIFIH	CARD18	1	P57730
MADRKHRKAFLEARQ	ADCY3	246	O60266
LEFESKMRKREHEFR	CCDC57	176	Q2TAC2
KMRKREHEFRLQADN	CCDC57	181	Q2TAC2
KRKIQEFHRTMLNFS	HASPIN	771	Q8TF76
AHGRMKEKEARSKFR	MARK3	146	P27448
LSRTFKMHKLLQQAR	MCF2	321	P10911
VFLVRHKSTRQRFAM	MAST2	526	Q6P0Q8
MRRLHLSERRDSFKK	MAST3	1251	O60307
FVRHKESRQRFAMKK	MAST4	586	O15021
EMPKAEKNAVSHRFR	ITPA	166	Q9BY32
EHVMKLRQAALKSAR	COLGALT1	141	Q8NBJ5
FAHVMKLRQAALRTA	COLGALT2	141	Q8IYK4
KRKRHELAFVCRMDT	HELZ2	1196	Q9BYK8
EVKRHPFFRNMNFKR	GRK5	441	P34947
KLRNQMAFSLFHRIS	DNA2	356	P51530
GRLTKHTKFVRDMIR	RPL36	31	Q9Y3U8
RLLAQIDASMFARKH	RUBCN	181	Q92622
KMVRNEKRFHRQAAE	DYRK2	251	Q92630
ALKMVRNEKRFHRQA	DYRK3	236	O43781
EMHDVKNHRTFLKRT	NME7	36	Q9Y5B8
TFRQQRKEHIRESMK	PLA2G4A	156	P47712
ISDLFARHRTKMRRK	MMP28	106	Q9H239
FFMLRKDSERRATLH	MAP3K5	1041	Q99683
ATDRMDAFRKAKNRA	MRPS5	261	P82675
FHDISLRFKRTHIKM	MRPS5	291	P82675
HFGSDLVRASMRRKK	SYTL1	96	Q8IYJ3
FRELFNKLHSRSKQM	SNX13	936	Q9Y5W8
MAAAFRKAAKSRQRE	UTP11	1	Q9Y3A2
RREILSHMQKVALFK	RGSL1	171	A5PLK6
RNSHAEFLDIMKRNR	TATDN1	151	Q6P1N9
AERFMAKTRSTKDHQ	SRGAP1	71	Q7Z6B7
KVKEMHLQDAARRRF	TBC1D31	766	Q96DN5
LMAQASAVLKRAHKR	SYNE1	6666	Q8NF91
QKFALFDEKHREEMR	TAF1L	1226	Q8IZX4
SDDQKRFEKRLMFSH	FASTKD2	196	Q9NYY8
EIFHRTMRKRLESFK	SLC9A3	651	P48764
ISHQMLKRRSFLKND	MEP1A	571	Q16819
RKRESVAKMSFRAAA	RHBDF1	206	Q96CC6
SISLHKKNMARYRDD	PKD1L3	1521	Q7Z443
CKKERDFLHENSMLR	POTEJ	601	P0CG39
FMITKFVQDRHRARR	RNF13	201	O43567
HKSEKFRAMATRTRQ	SIPA1L1	796	O43166
AHKSEKFRAMATRTR	SIPA1L2	791	Q9P2F8
AHGRMAEKEARRKFK	SIK3	156	Q9Y2K2
MKAILSFAKSHRFDV	SHPRH	1301	Q149N8
AFSMKNLHRRVKIED	IBSP	16	P21815
FATTLRNEIQMHRAK	SHROOM2	626	Q13796
FNKLSKVTIARERHM	SHROOM3	1571	Q8TF72
TLSAHFRNMSLKRIK	STAT5B	411	P51692
KRMFFLENKRRHCRS	RNF216	451	Q9NWF9
ASRSDIKLFKHNDMA	SPTLC1	201	O15269
FRAKDGMTALHKAAR	SHANK2	226	Q9UPX8
TSVMRLLSKHRAFED	SPTBN1	671	Q01082
TLSAHFRNMSLKRIK	STAT5A	411	P42229
RDKSMQDRLRLGHFT	TLK2	286	Q86UE8
AHSQIEKRRRDKMNS	ARNTL	76	O00327
DRDISGTLRKHMFFR	TBC1D3B	146	A6NDS4
DRDISGTLRKHMFFR	TBC1D3H	146	P0C7X1
RMALEFNRLASKVHK	TNIP1	186	Q15025
RREIAKALSKSFTMH	SLC30A8	331	Q8IWU4
FMHKRAQRLKFLCER	TNIK	1316	Q9UKE5
FREKTKHLRMESRDD	USP42	1291	Q9H9J4
KNHFVRALDMAKRTT	TYRP1	141	P17643
ASRMKRAAAKHLIER	UBE3A	21	Q05086
VFRSKLTMHTAFDRK	WDFY3	3391	Q8IZQ1
EALSHLMRRFAKTIN	UNC13C	1756	Q8NB66
FCHRLGKRERKQSFM	RNF112	11	Q9ULX5
ADRKRDAFMDHLKSK	SRCIN1	76	Q9C0H9
FMRFKERSHFHNIKA	TIGD1	136	Q96MW7
REIFHERKSQLMRKA	TIGD1	531	Q96MW7
RMFADDLHNLNKRIR	MRPL51	101	Q4U2R6
AKFLKRHMFDVASGR	SPATA20	536	Q8TB22
LKLNRRSRKVGSEHM	SUSD1	411	Q6UWL2
FMHLEALRQRTFIKD	TRAF6	476	Q9Y4K3
KAFAISMRLAEHRRI	ZNF574	801	Q6ZN55
KAFSRKSQLMVHQRT	ZNF577	221	Q9BSK1
DHDRRAMATLLSKFR	SLC12A2	1066	P55011
DHKKLVNTFRLMRRA	POLR3B	551	Q9NW08
GQRFRFSNMLKAHKE	ZBTB47	666	Q9UFB7
TAFRNKSMLFKRELQ	NDUFB1	36	O75438
KRFTQKSSLNVHMRL	ZBTB20	641	Q9HC78
FRRVCRFRHMEIDKK	ZC3H11B	46	A0A1B0GTU1
KAFSRKFMLTEHQRT	ZNF350	241	Q9GZX5
KAFRSMKNLQSHERT	ZNF69	451	Q9UC07
LLTQKRNVHMREKSF	ZNF28	201	P17035
ITFADSKFQERHMKR	ZNF576	41	Q9H609
MFKRHKSLASERKRA	TECRL	1	Q5HYJ1
KAFRSGSKLIQHQRM	ZNF345	321	Q14585
RRAMKRFNKGVHEDT	XPC	191	Q01831
RMRISTEFSKLHNFL	TRIM4	196	Q9C037
QRFRFSNMLKAHKEK	ZNF652	476	Q9Y2D9
DRDISGTLRKHMFFR	TBC1D3G	146	Q6DHY5
SFASKNKKDLRRHML	ZNF335	1081	Q9H4Z2
TFFRKKMTAADVSRH	ZFYVE26	2316	Q68DK2
KAFTQKSTLRMHQRI	ZNF81	421	P51508
HDRAVKFLMSRAKDG	VPS54	611	Q9P1Q0
GKAFKTRNQLSMHRI	ZNF311	281	Q5JNZ3
TFKNMQRRHTTLREK	TRPC7	6	Q9HCX4
KQRKDSFSHSRSRMN	TRPC7	206	Q9HCX4
NRRMTHLAQKFFPKA	XKR8	371	Q9H6D3
KAAEVARNLHMRLSK	KIAA0319	881	Q5VV43
ARNLHMRLSKEKADF	KIAA0319	886	Q5VV43
LFFTNRHEVRKMTLD	LDLR	401	P01130
LMFHIQKSRRFDEAR	PRKCH	441	P24723
VANAAYKAMKHRSRD	MYO1G	81	B0I1T2
LERRHFLQMKRAAVT	MYO9B	971	Q13459