Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	HCN4 SCN2A SCN3A HCN3 HCN2	5.96e-08	26	81	5	GO:0005248
GeneOntologyMolecularFunction	sodium channel activity	HCN4 SCN2A SCN3A HCN3 HCN2	2.17e-06	52	81	5	GO:0005272
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	HCN4 HCN3 HCN2	7.56e-06	10	81	3	GO:0005222
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN4 HCN3 HCN2	1.79e-05	13	81	3	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN4 HCN3 HCN2	1.79e-05	13	81	3	GO:0043855
GeneOntologyMolecularFunction	lipid binding	TLR10 LDLRAP1 ESYT3 STAM2 ESYT2 CETP CLVS2 LAMA1 UGT2B4 UGT2B7 PLCB2 PLD1 APOE DYSF	3.95e-05	988	81	14	GO:0008289
GeneOntologyMolecularFunction	phospholipid binding	LDLRAP1 ESYT3 STAM2 ESYT2 CETP CLVS2 PLCB2 PLD1 APOE DYSF	7.30e-05	548	81	10	GO:0005543
GeneOntologyMolecularFunction	cAMP binding	HCN4 HCN3 HCN2	1.39e-04	25	81	3	GO:0030552
GeneOntologyMolecularFunction	NAD transmembrane transporter activity	SLC25A52 SLC25A51	1.61e-04	5	81	2	GO:0051724
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN4 HCN3 HCN2	3.21e-04	33	81	3	GO:0005217
GeneOntologyMolecularFunction	phosphatidylcholine binding	ESYT3 ESYT2 CETP	3.51e-04	34	81	3	GO:0031210
GeneOntologyMolecularFunction	glucuronosyltransferase activity	UGT2B4 UGT2B7 EXT1	3.83e-04	35	81	3	GO:0015020
GeneOntologyMolecularFunction	phospholipase D activity	PLD6 PLD1	4.48e-04	8	81	2	GO:0004630
GeneOntologyMolecularFunction	cyclic nucleotide binding	HCN4 HCN3 HCN2	5.29e-04	39	81	3	GO:0030551
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	HCN4 SCN2A SCN3A HCN3 HCN2	6.58e-04	171	81	5	GO:0015081
GeneOntologyMolecularFunction	quaternary ammonium group binding	ESYT3 ESYT2 CETP	8.61e-04	46	81	3	GO:0050997
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	CLCA4 HCN4 HCN3 PACC1 HCN2	1.13e-03	193	81	5	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	CLCA4 HCN4 HCN3 PACC1 HCN2	1.24e-03	197	81	5	GO:0022834
GeneOntologyMolecularFunction	channel activity	CLCA4 HCN4 SCN2A SCN3A HCN3 PACC1 HCN2 SLC12A7	1.30e-03	525	81	8	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CLCA4 HCN4 SCN2A SCN3A HCN3 PACC1 HCN2 SLC12A7	1.31e-03	526	81	8	GO:0022803
GeneOntologyMolecularFunction	sodium ion binding	SCN2A SCN3A	1.43e-03	14	81	2	GO:0031402
GeneOntologyMolecularFunction	AP-2 adaptor complex binding	LDLRAP1 OTOF	1.43e-03	14	81	2	GO:0035612
GeneOntologyMolecularFunction	phosphatidylinositol binding	LDLRAP1 ESYT3 STAM2 ESYT2 CLVS2 PLD1	1.80e-03	316	81	6	GO:0035091
GeneOntologyMolecularFunction	calcium-dependent phospholipid binding	ESYT3 ESYT2 DYSF	1.86e-03	60	81	3	GO:0005544
GeneOntologyMolecularFunction	transporter activity	SLC17A5 CLCA4 HCN4 CETP SCN2A SCN3A HCN3 SLC25A52 PACC1 APOE HCN2 SLC12A7 SLC25A51	1.96e-03	1289	81	13	GO:0005215
GeneOntologyMolecularFunction	endonuclease activity	KHNYN PLD6 XRCC1 DNASE1L3	2.28e-03	136	81	4	GO:0004519
GeneOntologyMolecularFunction	gated channel activity	CLCA4 HCN4 SCN2A HCN3 PACC1 HCN2	2.37e-03	334	81	6	GO:0022836
GeneOntologyMolecularFunction	monoatomic ion channel activity	CLCA4 HCN4 SCN2A SCN3A HCN3 PACC1 HCN2	2.61e-03	459	81	7	GO:0005216
GeneOntologyMolecularFunction	phosphatidylethanolamine binding	ESYT3 ESYT2	2.66e-03	19	81	2	GO:0008429
GeneOntologyMolecularFunction	manganese ion binding	PAPOLA EXTL2 PCK2	3.01e-03	71	81	3	GO:0030145
GeneOntologyMolecularFunction	UDP-glycosyltransferase activity	UGT2B4 UGT2B7 EXT1 EXTL2	3.49e-03	153	81	4	GO:0008194
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC17A5 CLCA4 HCN4 SCN2A SCN3A HCN3 PACC1 HCN2 SLC12A7	3.55e-03	758	81	9	GO:0015318
GeneOntologyMolecularFunction	cholesterol transfer activity	CETP APOE	4.23e-03	24	81	2	GO:0120020
GeneOntologyMolecularFunction	sterol transfer activity	CETP APOE	4.59e-03	25	81	2	GO:0120015
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC17A5 CLCA4 HCN4 SCN2A SCN3A HCN3 PACC1 HCN2 SLC12A7	4.76e-03	793	81	9	GO:0015075
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	HCN4 HCN3 HCN2 SLC12A7	4.76e-03	167	81	4	GO:0015079
GeneOntologyMolecularFunction	adenine nucleotide transmembrane transporter activity	SLC25A52 SLC25A51	4.96e-03	26	81	2	GO:0000295
GeneOntologyMolecularFunction	alkali metal ion binding	SCN2A SCN3A	4.96e-03	26	81	2	GO:0031420
GeneOntologyMolecularFunction	retinoic acid binding	UGT2B4 UGT2B7	5.74e-03	28	81	2	GO:0001972
GeneOntologyMolecularFunction	purine nucleotide transmembrane transporter activity	SLC25A52 SLC25A51	6.15e-03	29	81	2	GO:0015216
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	HCN4 SCN2A HCN3 HCN2	6.44e-03	182	81	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	HCN4 SCN2A HCN3 HCN2	6.69e-03	184	81	4	GO:0022832
GeneOntologyMolecularFunction	phosphoric diester hydrolase activity	PLD6 PLCB2 PLD1	7.21e-03	97	81	3	GO:0008081
GeneOntologyMolecularFunction	nucleotide transmembrane transporter activity	SLC25A52 SLC25A51	7.91e-03	33	81	2	GO:0015215
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC17A5 CLCA4 HCN4 SCN2A SCN3A HCN3 SLC25A52 PACC1 HCN2 SLC12A7 SLC25A51	7.93e-03	1180	81	11	GO:0022857
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	HCN4 HCN3 HCN2	8.28e-03	102	81	3	GO:0005249
GeneOntologyMolecularFunction	amyloid-beta binding	LDLRAP1 APOE LRP8	8.28e-03	102	81	3	GO:0001540
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor binding	LDLRAP1 APOE	8.38e-03	34	81	2	GO:0050750
GeneOntologyMolecularFunction	lipoprotein particle binding	APOE LRP8	8.87e-03	35	81	2	GO:0071813
GeneOntologyMolecularFunction	protein-lipid complex binding	APOE LRP8	8.87e-03	35	81	2	GO:0071814
GeneOntologyBiologicalProcess	membrane depolarization during action potential	HCN4 SCN2A SCN3A HCN2	1.07e-05	36	79	4	GO:0086010
GeneOntologyBiologicalProcess	mitochondrial NAD transmembrane transport	SLC25A52 SLC25A51	1.45e-05	2	79	2	GO:1990549
GeneOntologyCellularComponent	HCN channel complex	HCN4 HCN3 HCN2	2.24e-07	4	81	3	GO:0098855
GeneOntologyCellularComponent	TORC1 complex	MTOR RPTOR	2.20e-04	6	81	2	GO:0031931
GeneOntologyCellularComponent	dendrite	CHL1 PTPRK HCN4 MTOR RPTOR HCN3 ITGA8 PRKCG APOE HCN2 LRP8	4.59e-04	858	81	11	GO:0030425
GeneOntologyCellularComponent	dendritic tree	CHL1 PTPRK HCN4 MTOR RPTOR HCN3 ITGA8 PRKCG APOE HCN2 LRP8	4.68e-04	860	81	11	GO:0097447
GeneOntologyCellularComponent	endocytic vesicle	LDLRAP1 STAM2 MTOR CD207 PLD1 APOE DYSF	7.24e-04	384	81	7	GO:0030139
GeneOntologyCellularComponent	TOR complex	MTOR RPTOR	9.54e-04	12	81	2	GO:0038201
GeneOntologyCellularComponent	endoplasmic reticulum-plasma membrane contact site	ESYT3 ESYT2	1.13e-03	13	81	2	GO:0140268
GeneOntologyCellularComponent	neuronal cell body	PTPRK HCN4 MTOR RPTOR SCN3A HCN3 ITGA8 APOE HCN2 LRP8	1.42e-03	835	81	10	GO:0043025
HumanPheno	Renal steatosis	LDLRAP1 APOE PCK2	2.38e-05	11	28	3	HP:0000799
Domain	Ion_trans_N	HCN4 HCN3 HCN2	2.79e-07	4	78	3	PF08412
Domain	Ion_trans_N	HCN4 HCN3 HCN2	2.79e-07	4	78	3	IPR013621
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.50e-05	12	78	3	PF15371
Domain	DUF4599	SPATA31A3 SPATA31A7 SPATA31A5	1.50e-05	12	78	3	IPR027970
Domain	C2	ESYT3 ESYT2 OTOF PRKCG PLCB2 DYSF	1.80e-05	131	78	6	PF00168
Domain	C2	ESYT3 ESYT2 OTOF PRKCG PLCB2 DYSF	2.32e-05	137	78	6	SM00239
Domain	K_chnl_volt-dep_EAG/ELK/ERG	HCN4 HCN3 HCN2	2.47e-05	14	78	3	IPR003938
Domain	C2	ESYT3 ESYT2 OTOF PRKCG PLCB2 DYSF	2.85e-05	142	78	6	PS50004
Domain	-	ESYT3 ESYT2 OTOF PRKCG PLCB2 DYSF	3.59e-05	148	78	6	2.60.40.150
Domain	SMP_LBD	ESYT3 ESYT2	5.15e-05	3	78	2	PF17047
Domain	SMP_LBD	ESYT3 ESYT2	5.15e-05	3	78	2	IPR031468
Domain	PLDc_2	PLD6 PLD1	5.15e-05	3	78	2	PF13091
Domain	PLD-like_dom	PLD6 PLD1	5.15e-05	3	78	2	IPR025202
Domain	C2_dom	ESYT3 ESYT2 OTOF PRKCG PLCB2 DYSF	6.37e-05	164	78	6	IPR000008
Domain	Ion_trans_dom	HCN4 SCN2A SCN3A HCN3 HCN2	1.15e-04	114	78	5	IPR005821
Domain	Ion_trans	HCN4 SCN2A SCN3A HCN3 HCN2	1.15e-04	114	78	5	PF00520
Domain	FerI	OTOF DYSF	1.71e-04	5	78	2	SM01202
Domain	FerB	OTOF DYSF	1.71e-04	5	78	2	SM01201
Domain	Ferlin_B-domain	OTOF DYSF	1.71e-04	5	78	2	IPR012561
Domain	Ferlin_C	OTOF DYSF	1.71e-04	5	78	2	PF16165
Domain	Ferlin_C	OTOF DYSF	1.71e-04	5	78	2	IPR032362
Domain	FerIin_dom	OTOF DYSF	1.71e-04	5	78	2	IPR012968
Domain	FerI	OTOF DYSF	1.71e-04	5	78	2	PF08151
Domain	FerB	OTOF DYSF	1.71e-04	5	78	2	PF08150
Domain	Glyco_transf_64	EXT1 EXTL2	1.71e-04	5	78	2	PF09258
Domain	FATC	MTOR PRKDC	1.71e-04	5	78	2	PF02260
Domain	EXT_C	EXT1 EXTL2	1.71e-04	5	78	2	IPR015338
Domain	Na_trans_cytopl	SCN2A SCN3A	2.55e-04	6	78	2	PF11933
Domain	FAT	MTOR PRKDC	2.55e-04	6	78	2	PS51189
Domain	FATC	MTOR PRKDC	2.55e-04	6	78	2	PS51190
Domain	FAT	MTOR PRKDC	2.55e-04	6	78	2	PF02259
Domain	PIK-rel_kinase_FAT	MTOR PRKDC	2.55e-04	6	78	2	IPR003151
Domain	FATC_dom	MTOR PRKDC	2.55e-04	6	78	2	IPR003152
Domain	PIK_FAT	MTOR PRKDC	2.55e-04	6	78	2	IPR014009
Domain	PLDc	PLD6 PLD1	2.55e-04	6	78	2	SM00155
Domain	Na_trans_cytopl	SCN2A SCN3A	2.55e-04	6	78	2	IPR024583
Domain	FATC	MTOR PRKDC	2.55e-04	6	78	2	SM01343
Domain	CNMP_BINDING_1	HCN4 HCN3 HCN2	3.19e-04	32	78	3	PS00888
Domain	CNMP_BINDING_2	HCN4 HCN3 HCN2	3.19e-04	32	78	3	PS00889
Domain	PLipase_D/transphosphatidylase	PLD6 PLD1	3.57e-04	7	78	2	IPR001736
Domain	PLD	PLD6 PLD1	3.57e-04	7	78	2	PS50035
Domain	cNMP	HCN4 HCN3 HCN2	3.82e-04	34	78	3	SM00100
Domain	cNMP_binding	HCN4 HCN3 HCN2	3.82e-04	34	78	3	PF00027
Domain	cNMP-bd_dom	HCN4 HCN3 HCN2	4.17e-04	35	78	3	IPR000595
Domain	CNMP_BINDING_3	HCN4 HCN3 HCN2	4.17e-04	35	78	3	PS50042
Domain	cNMP-bd-like	HCN4 HCN3 HCN2	5.32e-04	38	78	3	IPR018490
Domain	Na_channel_asu	SCN2A SCN3A	7.58e-04	10	78	2	IPR001696
Domain	Na_trans_assoc	SCN2A SCN3A	7.58e-04	10	78	2	IPR010526
Domain	Na_trans_assoc	SCN2A SCN3A	7.58e-04	10	78	2	PF06512
Domain	-	HCN4 HCN3 HCN2	1.06e-03	48	78	3	2.60.120.10
Domain	RmlC-like_jellyroll	HCN4 HCN3 HCN2	1.26e-03	51	78	3	IPR014710
Domain	PI3/4_kinase_CS	MTOR PRKDC	1.75e-03	15	78	2	IPR018936
Domain	HEAT	MTOR RPTOR PRKDC	1.83e-03	58	78	3	IPR000357
Domain	cNMP-bd_CS	HCN4 HCN2	1.99e-03	16	78	2	IPR018488
Domain	-	MTOR PRKDC	1.99e-03	16	78	2	1.10.1070.11
Domain	PI3Kc	MTOR PRKDC	1.99e-03	16	78	2	SM00146
Domain	-	MTOR RPTOR MROH5 PRKDC XPOT	2.37e-03	222	78	5	1.25.10.10
Domain	PI3/4_kinase_cat_dom	MTOR PRKDC	2.52e-03	18	78	2	IPR000403
Domain	PI3_PI4_kinase	MTOR PRKDC	2.52e-03	18	78	2	PF00454
Domain	PI3_4_KINASE_3	MTOR PRKDC	2.52e-03	18	78	2	PS50290
Domain	PI3_4_KINASE_1	MTOR PRKDC	2.52e-03	18	78	2	PS00915
Domain	PI3_4_KINASE_2	MTOR PRKDC	2.52e-03	18	78	2	PS00916
Domain	ARM-type_fold	MTOR RPTOR MROH5 CTIF PRKDC XPOT	2.93e-03	339	78	6	IPR016024
Domain	UDPGT	UGT2B4 UGT2B7	3.43e-03	21	78	2	PF00201
Domain	UDPGT	UGT2B4 UGT2B7	3.43e-03	21	78	2	PS00375
Domain	UDP_glucos_trans	UGT2B4 UGT2B7	3.43e-03	21	78	2	IPR002213
Domain	TIR_dom	TLR10 IL17RD	4.85e-03	25	78	2	IPR000157
Pathway	WP_METABOLIC_PATHWAY_OF_LDL_HDL_AND_TG_INCLUDING_DISEASES	LDLRAP1 CETP APOE	4.54e-05	17	59	3	M39747
Pathway	REACTOME_CHYLOMICRON_CLEARANCE	LDLRAP1 APOE	1.71e-04	5	59	2	MM15564
Pathway	REACTOME_CHYLOMICRON_CLEARANCE	LDLRAP1 APOE	1.71e-04	5	59	2	M27845
Pathway	PID_IL8_CXCR1_PATHWAY	PRKCG PLCB2 PLD1	2.12e-04	28	59	3	M252
Pathway	WP_DRAVET_SYNDROME	MTOR SCN2A SCN3A	2.12e-04	28	59	3	M45519
Pathway	WP_FACTORS_AND_PATHWAYS_AFFECTING_INSULINLIKE_GROWTH_FACTOR_IGF1AKT_SIGNALING	MTOR RPTOR PLD1	4.51e-04	36	59	3	M39569
Pathway	REACTOME_GLYCOSPHINGOLIPID_TRANSPORT	ESYT3 ESYT2	4.74e-04	8	59	2	M48263
Pathway	REACTOME_GLYCOSPHINGOLIPID_TRANSPORT	ESYT3 ESYT2	4.74e-04	8	59	2	MM17237
Pathway	REACTOME_SYNTHESIS_OF_PG	PLD6 PLD1	4.74e-04	8	59	2	M26961
Pathway	WP_MELATONIN_METABOLISM_AND_EFFECTS	ASMT APOE CLOCK	4.89e-04	37	59	3	M39418
Pathway	WP_SMITHMAGENIS_AND_POTOCKILUPSKI_SYNDROME_COPY_NUMBER_VARIATION	MTOR RPTOR PLD6 IFT80 CLOCK	5.25e-04	159	59	5	M48090
Pubmed	Functional expression of the human HCN3 channel.	HCN4 HCN3 HCN2	4.86e-08	4	81	3	16043489
Pubmed	Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels.	HCN4 HCN3 HCN2	4.86e-08	4	81	3	9405696
Pubmed	Role of subunit heteromerization and N-linked glycosylation in the formation of functional hyperpolarization-activated cyclic nucleotide-gated channels.	HCN4 HCN3 HCN2	4.86e-08	4	81	3	12928435
Pubmed	Hyperpolarization-activated and cyclic nucleotide-gated channels are differentially expressed in juxtaglomerular cells in the olfactory bulb of mice.	HCN4 HCN3 HCN2	4.86e-08	4	81	3	20140458
Pubmed	Investigation of hyperpolarization-activated cyclic nucleotide-gated channels in interstitial cells of Cajal of human bladder.	HCN4 HCN3 HCN2	4.86e-08	4	81	3	22748890
Pubmed	Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.	HCN4 HCN3 HCN2	4.86e-08	4	81	3	9630217
Pubmed	Genetic analysis of hyperpolarization-activated cyclic nucleotide-gated cation channels in sudden unexpected death in epilepsy cases.	HCN4 HCN3 HCN2	4.86e-08	4	81	3	21615589
Pubmed	Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction.	HCN4 HCN3 HCN2	1.21e-07	5	81	3	15564593
Pubmed	Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice.	HCN4 HCN3 HCN2	1.21e-07	5	81	3	34429357
Pubmed	The testis-specific VAD1.3/AEP1 interacts with β-actin and syntaxin 1 and directs peri-nuclear/Golgi expression with bipartite nucleus localization (BNL) sequence.	SPATA31A3 SPATA31A7 SPATA31A5	2.42e-07	6	81	3	20850414
Pubmed	Targeted disruption of the spermatid-specific gene Spata31 causes male infertility.	SPATA31A3 SPATA31A7 SPATA31A5	2.42e-07	6	81	3	25930072
Pubmed	Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts.	HCN4 HCN3 HCN2	4.23e-07	7	81	3	27956497
Pubmed	Transcription profiling of HCN-channel isotypes throughout mouse cardiac development.	HCN4 HCN3 HCN2	4.23e-07	7	81	3	19421833
Pubmed	LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer.	PRKDC APOE LRP8	6.76e-07	8	81	3	29336888
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	TLR10 IL10RB PDCD6IP KHNYN CHD7 TNFRSF10A IL17RD DNASE1L3	7.16e-07	313	81	8	20800603
Pubmed	International Union of Pharmacology. LI. Nomenclature and structure-function relationships of cyclic nucleotide-regulated channels.	HCN4 HCN3 HCN2	1.44e-06	10	81	3	16382102
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	TTLL12 ESYT2 PDCD6IP PTPRK MTOR RPTOR MTX3 NUP210 PRKDC CORO7 PCK2 XPOT	1.85e-06	942	81	12	31073040
Pubmed	Tti1 and Tel2 are critical factors in mammalian target of rapamycin complex assembly.	MTOR RPTOR PRKDC	1.98e-06	11	81	3	20427287
Pubmed	Defining brain wiring patterns and mechanisms through gene trapping in mice.	PTPRK LAMA1 IL17RD	4.35e-06	14	81	3	11242070
Pubmed	Pacsin 2 is required for the maintenance of a normal cardiac function in the developing mouse heart.	HCN4 HCN3 HCN2	4.35e-06	14	81	3	29107716
Pubmed	Compartmental distribution of hyperpolarization-activated cyclic-nucleotide-gated channel 2 and hyperpolarization-activated cyclic-nucleotide-gated channel 4 in thalamic reticular and thalamocortical relay neurons.	HCN4 HCN2	5.36e-06	2	81	2	16806719
Pubmed	The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†.	MTOR RPTOR	5.36e-06	2	81	2	30202948
Pubmed	CSF-ApoER2 fragments as a read-out of reelin signaling: Distinct patterns in sporadic and autosomal-dominant Alzheimer disease.	APOE LRP8	5.36e-06	2	81	2	30552869
Pubmed	Array-CGH detection of a de novo 2.8 Mb deletion in 2q24.2-->q24.3 in a girl with autistic features and developmental delay.	SCN2A SCN3A	5.36e-06	2	81	2	20346423
Pubmed	Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia.	MTOR PRKDC	5.36e-06	2	81	2	27235137
Pubmed	The Hyperpolarization-Activated HCN4 Channel is Important for Proper Maintenance of Oscillatory Activity in the Thalamocortical System.	HCN4 HCN2	5.36e-06	2	81	2	30877792
Pubmed	Genetic variants in lipid metabolism are independently associated with multiple features of the metabolic syndrome.	CETP APOE	5.36e-06	2	81	2	21767357
Pubmed	Frequency of Cardiovascular Genetic Risk Factors in a Calabrian Population and Their Effects on Dementia.	CETP APOE	5.36e-06	2	81	2	29332048
Pubmed	Expression of UDP-glucuronosyltransferases (UGTs) 2B7 and 1A6 in the human brain and identification of 5-hydroxytryptamine as a substrate.	UGT2B4 UGT2B7	5.36e-06	2	81	2	10222050
Pubmed	Hyperpolarization-activated cyclic nucleotide-modulated 'HCN' channels confer regular and faster rhythmicity to beating mouse embryonic stem cells.	HCN3 HCN2	5.36e-06	2	81	2	18033814
Pubmed	Bexarotene induces dyslipidemia by increased very low-density lipoprotein production and cholesteryl ester transfer protein-mediated reduction of high-density lipoprotein.	CETP APOE	5.36e-06	2	81	2	19147676
Pubmed	Studies of the CETP TaqIB and ApoE Polymorphisms in Southern Thai Subjects with the Metabolic Syndrome.	CETP APOE	5.36e-06	2	81	2	26014924
Pubmed	Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice.	CETP APOE	5.36e-06	2	81	2	18669886
Pubmed	Genomic structures of SCN2A and SCN3A - candidate genes for deafness at the DFNA16 locus.	SCN2A SCN3A	5.36e-06	2	81	2	11245985
Pubmed	Cholesteryl ester transfer protein genotype modifies the effect of apolipoprotein ε4 on memory decline in older adults.	CETP APOE	5.36e-06	2	81	2	27033407
Pubmed	Association between polymorphisms in DNA repair genes (XRCC1 and XRCC7) and risk of preeclampsia.	PRKDC XRCC1	5.36e-06	2	81	2	22825692
Pubmed	Duplication of the sodium channel gene cluster on 2q24 in children with early onset epilepsy.	SCN2A SCN3A	5.36e-06	2	81	2	23016767
Pubmed	Whole gene duplication of SCN2A and SCN3A is associated with neonatal seizures and a normal intellectual development.	SCN2A SCN3A	5.36e-06	2	81	2	27153334
Pubmed	Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells.	HCN4 HCN2	5.36e-06	2	81	2	12194012
Pubmed	DNA-PK, Nuclear mTOR, and the Androgen Pathway in Prostate Cancer.	MTOR PRKDC	5.36e-06	2	81	2	32209447
Pubmed	Hepatic overexpression of a dominant negative form of raptor enhances Akt phosphorylation and restores insulin sensitivity in K/KAy mice.	MTOR RPTOR	5.36e-06	2	81	2	18270303
Pubmed	Effect of Dysferlin Deficiency on Atherosclerosis and Plasma Lipoprotein Composition Under Normal and Hyperlipidemic Conditions.	APOE DYSF	5.36e-06	2	81	2	34366880
Pubmed	Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33.	UGT2B4 UGT2B7	5.36e-06	2	81	2	17263731
Pubmed	Sex differences in the development of vascular and renal lesions in mice with a simultaneous deficiency of Apoe and the integrin chain Itga8.	ITGA8 APOE	5.36e-06	2	81	2	28572914
Pubmed	Association of polymorphism of DNA repair gene XRCC1 with sporadic late-onset Alzheimer's disease and age of onset in elderly Han Chinese.	XRCC1 APOE	5.36e-06	2	81	2	20553853
Pubmed	Increased nonHDL cholesterol levels cause muscle wasting and ambulatory dysfunction in the mouse model of LGMD2B.	APOE DYSF	5.36e-06	2	81	2	29175948
Pubmed	Cholesteryl ester transfer protein (CETP) polymorphism modifies the Alzheimer's disease risk associated with APOE epsilon4 allele.	CETP APOE	5.36e-06	2	81	2	16096813
Pubmed	CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner.	CETP APOE	5.36e-06	2	81	2	21892657
Pubmed	Association of cholesteryl ester transfer protein (TaqIB) and apolipoprotein E (HhaI) gene variants with obesity.	CETP APOE	5.36e-06	2	81	2	18454345
Pubmed	The Genetic Architecture of Diet-Induced Hepatic Fibrosis in Mice.	CETP APOE	5.36e-06	2	81	2	29907965
Pubmed	Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.	UGT2B4 UGT2B7	5.36e-06	2	81	2	15319348
Pubmed	Gene-gene interaction between CETP and APOE polymorphisms confers higher risk for hypertriglyceridemia in oldest-old Chinese women.	CETP APOE	5.36e-06	2	81	2	24746514
Pubmed	Deletion of mTORC1 Activity in CD4+ T Cells Is Associated with Lung Fibrosis and Increased γδ T Cells.	MTOR RPTOR	5.36e-06	2	81	2	27649073
Pubmed	Interaction between a common variant of the cholesteryl ester transfer protein gene and the apolipoprotein E polymorphism: effects on plasma lipids and lipoproteins in a cohort of 7-year-old children.	CETP APOE	5.36e-06	2	81	2	12669678
Pubmed	Phospholipase D regulates the size of skeletal muscle cells through the activation of mTOR signaling.	MTOR PLD1	5.36e-06	2	81	2	23915343
Pubmed	Blockade of PLD1 potentiates the antitumor effects of bortezomib in multiple myeloma cells by inhibiting the mTOR/NF-κB signal pathway.	MTOR PLD1	5.36e-06	2	81	2	33191863
Pubmed	SLC25A51 is a mammalian mitochondrial NAD+ transporter.	SLC25A52 SLC25A51	5.36e-06	2	81	2	32906142
Pubmed	mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors.	MTOR RPTOR	5.36e-06	2	81	2	29786082
Pubmed	Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning.	MTOR RPTOR	5.36e-06	2	81	2	27018708
Pubmed	The mammalian target of rapamycin (mTOR) pathway regulates mitochondrial oxygen consumption and oxidative capacity.	MTOR RPTOR	5.36e-06	2	81	2	16847060
Pubmed	Effects of the cholesteryl ester transfer protein inhibitor torcetrapib on VLDL apolipoprotein E metabolism.	CETP APOE	5.36e-06	2	81	2	18033754
Pubmed	Proteolytic processing of HCN2 and co-assembly with HCN4 in the generation of cardiac pacemaker channels.	HCN4 HCN2	5.36e-06	2	81	2	19574228
Pubmed	Morphoproteomic analysis reveals an overexpressed and constitutively activated phospholipase D1-mTORC2 pathway in endometrial carcinoma.	MTOR PLD1	5.36e-06	2	81	2	21228924
Pubmed	E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains.	ESYT3 ESYT2	5.36e-06	2	81	2	17360437
Pubmed	HCN2 and HCN4 isoforms self-assemble and co-assemble with equal preference to form functional pacemaker channels.	HCN4 HCN2	5.36e-06	2	81	2	17553794
Pubmed	mTOR kinase-dependent, but raptor-independent regulation of downstream signaling is important for cell cycle exit and myogenic differentiation.	MTOR RPTOR	5.36e-06	2	81	2	25486193
Pubmed	Association of CETP TaqI and APOE polymorphisms with type II diabetes mellitus in North Indians: a case control study.	CETP APOE	5.36e-06	2	81	2	15992403
Pubmed	Molecular basis for the different activation kinetics of the pacemaker channels HCN2 and HCN4.	HCN4 HCN2	5.36e-06	2	81	2	12813043
Pubmed	Partial dysferlin reconstitution by adult murine mesoangioblasts is sufficient for full functional recovery in a murine model of dysferlinopathy.	PRKDC DYSF	5.36e-06	2	81	2	21364666
Pubmed	PLD1 is overexpressed in an ER-negative MCF-7 cell line variant and a subset of phospho-Akt-negative breast carcinomas.	MTOR PLD1	5.36e-06	2	81	2	17726467
Pubmed	Two pacemaker channels from human heart with profoundly different activation kinetics.	HCN4 HCN2	5.36e-06	2	81	2	10228147
Pubmed	[The effect of apolipoprotein e polymorphism on plasma cholesteryl ester transfer protein activity in type 2 diabetic patients].	CETP APOE	5.36e-06	2	81	2	19140312
Pubmed	The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease.	CETP APOE	5.36e-06	2	81	2	17503098
Pubmed	Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.	APOE LRP8	5.36e-06	2	81	2	25197062
Pubmed	The effect of the APOE polymorphism on HDL-C concentrations depends on the cholesterol ester transfer protein gene variation in a Southern European population.	CETP APOE	5.36e-06	2	81	2	16426594
Pubmed	Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels.	HCN4 HCN2	5.36e-06	2	81	2	16777944
Pubmed	Constitutive activation with overexpression of the mTORC2-phospholipase D1 pathway in uterine leiomyosarcoma and STUMP: morphoproteomic analysis with therapeutic implications.	MTOR PLD1	5.36e-06	2	81	2	21326806
Pubmed	Low-density lipoprotein receptor-related protein 8 gene polymorphisms and dementia.	APOE LRP8	5.36e-06	2	81	2	17614163
Pubmed	Cholesteryl ester transfer protein polymorphism D442G associated with a potential decreased risk for Alzheimer's disease as a modifier for APOE epsilon4 in Chinese.	CETP APOE	5.36e-06	2	81	2	18036514
Pubmed	Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.	MTOR RPTOR	5.36e-06	2	81	2	17301289
Pubmed	Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice.	CETP APOE	5.36e-06	2	81	2	32915671
Pubmed	Apolipoprotein E and cholesteryl ester transfer protein polymorphisms in normal and preeclamptic pregnancies.	CETP APOE	5.36e-06	2	81	2	14687732
Pubmed	Lack of genetic association of cholesteryl ester transfer protein polymorphisms with late onset Alzheimers disease.	CETP APOE	5.36e-06	2	81	2	15882786
Pubmed	Association of CETP polymorphisms with the risk of vascular dementia and white matter lesions.	CETP APOE	5.36e-06	2	81	2	19184337
Pubmed	Conditional Knockout of Raptor/mTORC1 Results in Dentin Malformation.	MTOR RPTOR	5.36e-06	2	81	2	30984011
Pubmed	Domains of apoE required for binding to apoE receptor 2 and to phospholipids: implications for the functions of apoE in the brain.	APOE LRP8	5.36e-06	2	81	2	12950167
Pubmed	HCN3 ion channels: roles in sensory neuronal excitability and pain.	HCN3 HCN2	5.36e-06	2	81	2	31290157
Pubmed	Cholesterol ester transfer protein and apolipoprotein E gene polymorphisms in hyperlipidemic Asian Indians in North India.	CETP APOE	5.36e-06	2	81	2	21380728
Pubmed	Apolipoprotein E knockout, but not cholesteryl ester transfer protein (CETP)-associated high-density lipoprotein cholesterol (HDL-C) lowering, exacerbates muscle wasting in dysferlin-null mice.	APOE DYSF	5.36e-06	2	81	2	39138561
Pubmed	Hepatic peroxisomal β-oxidation suppresses lipophagy via RPTOR acetylation and MTOR activation.	MTOR RPTOR	5.36e-06	2	81	2	32687428
Pubmed	Association of APOE and CETP TaqIB Polymorphisms with Type 2 Diabetes Mellitus.	CETP APOE	5.36e-06	2	81	2	30853126
Pubmed	CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study.	CETP APOE	5.36e-06	2	81	2	17519358
Pubmed	Nonalcoholic fatty liver disease in CLOCK mutant mice.	APOE CLOCK	5.36e-06	2	81	2	32396530
Pubmed	Absence of T and B lymphocytes modulates dystrophic features in dysferlin deficient animal model.	PRKDC DYSF	5.36e-06	2	81	2	22465227
Pubmed	Polymorphisms in the human apolipoprotein E receptor 2 gene in Japanese sporadic Alzheimer's disease patients.	APOE LRP8	5.36e-06	2	81	2	20208369
Pubmed	Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias.	HCN4 HCN2	5.36e-06	2	81	2	15687126
Pubmed	Control of heart rate by cAMP sensitivity of HCN channels.	HCN4 HCN2	5.36e-06	2	81	2	19570998
Pubmed	XRCC1 is phosphorylated by DNA-dependent protein kinase in response to DNA damage.	PRKDC XRCC1	5.36e-06	2	81	2	16397295
Pubmed	cPKCγ-Modulated Sequential Reactivation of mTOR Inhibited Autophagic Flux in Neurons Exposed to Oxygen Glucose Deprivation/Reperfusion.	MTOR PRKCG	5.36e-06	2	81	2	29734780
Pubmed	The human cholesteryl ester transfer protein I405V polymorphism is associated with plasma cholesterol concentration and its reduction by dietary phytosterol esters.	CETP APOE	5.36e-06	2	81	2	12771320
Interaction	HCN4 interactions	HCN4 HCN3 HCN2	4.97e-06	9	80	3	int:HCN4
Cytoband	Ensembl 112 genes in cytogenetic band chr9q12	SPATA31A7 SPATA31A5	8.55e-05	8	81	2	chr9q12
Cytoband	4q13	UGT2B4 UGT2B7	3.18e-04	15	81	2	4q13
Cytoband	3p14.3	IL17RD DNASE1L3	1.30e-03	30	81	2	3p14.3
GeneFamily	Ferlin family	OTOF FER1L4 DYSF	6.90e-07	6	60	3	828
GeneFamily	Cyclic nucleotide gated channels	HCN4 HCN3 HCN2	4.10e-06	10	60	3	250
GeneFamily	Extended synaptotagmins	ESYT3 ESYT2	3.24e-05	3	60	2	827
GeneFamily	MTOR complex 1\|MTOR complex 2	MTOR RPTOR	6.47e-05	4	60	2	1332
GeneFamily	Exostosin glycosyltransferase family	EXT1 EXTL2	1.08e-04	5	60	2	431
GeneFamily	Phospholipases	PLD6 PLCB2 PLD1	3.64e-04	42	60	3	467
GeneFamily	Sodium voltage-gated channel alpha subunits	SCN2A SCN3A	3.84e-04	9	60	2	1203
GeneFamily	UDP glucuronosyltransferases	UGT2B4 UGT2B7	5.04e-03	32	60	2	363
ToppCell	Tracheal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 PLCB2 HCN2 DYSF SLC12A7 DNASE1L3	1.57e-06	196	81	6	b71d711be5609115b00a57700885aca608920896
ToppCell	droplet-Tongue-Unstain-18m-Epithelial-nan\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 PTPRK CTBS PACC1 PLD1	4.48e-06	133	81	5	f7d0763b5eec2db33044d6850fd57462494038c1
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OTOF ASMT CD207 DNASE1L3 LRP8	1.13e-05	161	81	5	76c993a4533362db2250c88b3ee3ede55362d54e
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	OTOF ASMT CD207 DNASE1L3 LRP8	1.24e-05	164	81	5	5638d95c7cc5e59c4a7bda30268a904a01861a5f
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ESYT3 OTOF CD207 PLCB2 DNASE1L3	1.65e-05	174	81	5	6688424fc4e40c3c4a89669a2bc79369a726f1e6
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TLR10 CHL1 PTPRK SCN3A LIX1	1.74e-05	176	81	5	ad05dd934f4ac2e656b3455de091f4c8772de6c8
ToppCell	COVID-19-B_cells-Activated_B_cells\|COVID-19 / group, cell type (main and fine annotations)	TLR10 SCN3A NUP210 CHD7 LIX1	1.79e-05	177	81	5	653bb62a3744d4024ab3186ee01d410ed62832a6
ToppCell	10x5'v1-week_17-19-Myeloid_macrophage-stroma-erythroid_macrophage\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	CETP TLCD4 GPR137B TMEM225B APOE	1.79e-05	177	81	5	b647667da62a91dbe3890820142626e26aa779d2
ToppCell	facs-Lung-EPCAM-3m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 OTOF CD207 PLCB2 DNASE1L3	1.84e-05	178	81	5	8c5e9fab7b55a654ccaabf2c4d02397399d94616
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)\|Striatum / BrainAtlas - Mouse McCarroll V32	OTOF SCN2A SCN3A ARHGEF9 PRKCG	2.39e-05	188	81	5	e34ea7014c5a059a7db38f78bd903cf02616ddd3
ToppCell	3'-Child09-12-SmallIntestine-Hematopoietic-Myeloid-MMP9+_Inflammatory_macrophage\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CETP GPR137B PLD6 APOE DNASE1L3	2.39e-05	188	81	5	f955f2eb92f399958d4d713e31af77d93fb4a6ec
ToppCell	severe-B_cell\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CHL1 SCN2A SCN3A CHD7 TNFRSF10A	2.78e-05	194	81	5	2fee6083fb56b16d1f04fd0b92ec622fd26ba3fa
ToppCell	COVID-19_Moderate-B_naive\|World / disease group, cell group and cell class	TLR10 PTPRK SCN3A CHD7 LIX1	2.78e-05	194	81	5	1f81d618799e482a36dce528bba70f52cc69a901
ToppCell	Bronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	IL10RB OTOF CLVS2 SCN2A SCN3A	2.92e-05	196	81	5	4bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A2_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHL1 MMP24 SCN2A SCN3A LIX1	2.99e-05	197	81	5	27c044833e471a312a572e0b1c83e4bc8a36e896
ToppCell	Parenchymal-NucSeq-Immune_Myeloid-Dendritic_cell-DC_1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TLR10 GPR137B PLCB2 DYSF DNASE1L3	3.07e-05	198	81	5	fa5c15a656d4132950092919600e270f1fd79abf
ToppCell	mild-B_naive\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	TLR10 CHL1 PTPRK SCN3A CHD7	3.22e-05	200	81	5	d0467cab6a42bf780aa49046bf3231ca161dc144
ToppCell	Tracheal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_naive\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MTOR MTX3 PLCB2 CHD7	3.49e-05	101	81	4	86acaa2502f61baa714ae988b73e3e73a71e897e
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-2\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	CLCA4 OTOF ITGA8 APOE	8.01e-05	125	81	4	6cd741dd1c7ee6b16437cca7c15c99b5c95603fc
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	ESYT3 MMP24 OTOF DYSF	9.05e-05	129	81	4	e50bd63ad8035abf5135d7d2cb8636206d6e69a5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CHL1 SCN3A TMEM225B LRP8	1.24e-04	140	81	4	276b3fa924176426efb31112ed4d355407f0b218
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 LAMA1 UGT2B7 LIX1	1.31e-04	142	81	4	6469cf82552b39f63e20b841c9eed50de6f58d54
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	MTX3 UGT2B7 CTIF APOE	1.42e-04	145	81	4	47a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TLR10 CD207 PRKCG PLCB2	1.54e-04	148	81	4	12fa2c4922f03803006c606b1b16e79441e3bb13
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_artery-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CHL1 TRABD2A SCN2A TNFRSF10A	1.66e-04	151	81	4	3b4c57bad61e17a573e6f8dc6b917fba5fd56c43
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Granulocytic-Neutrophil-Neu_c2-CXCR4(low)\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	PRKCG PLCB2 PRKDC XRCC1	1.66e-04	151	81	4	b698ddc74565d47892c09c3f16d78038da2dd5e7
ToppCell	droplet-Thymus-nan-21m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOF CD207 ITGA8 DNASE1L3	2.12e-04	161	81	4	441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCell	droplet-Heart-nan-24m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 NUP210 PLCB2 DNASE1L3	2.12e-04	161	81	4	7e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHL1 CLVS2 LAMA1 CHD7	2.22e-04	163	81	4	99cf60dc87f7ce288553091bffcd85109a02bd8f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Neuronal-neuron_precursor-Neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CHL1 CLVS2 LAMA1 CHD7	2.22e-04	163	81	4	510c0af66e82c5a8cf8edd0547dae4018a87dbbf
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TLR10 TRABD2A CD207 DNASE1L3	2.28e-04	164	81	4	43045879505774ac0d9b7f760557955564f06d00
ToppCell	metastatic_Brain-Myeloid_cells-pDCs\|metastatic_Brain / Location, Cell class and cell subclass	TLR10 CORO7 HCN2 DNASE1L3	2.28e-04	164	81	4	06db4cc064f0765c481ce880207823872c27bfa9
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TLR10 CHL1 PTPRK SCN3A	2.33e-04	165	81	4	fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	TLR10 GPR137B DYSF DNASE1L3	2.38e-04	166	81	4	63dc58864268b4e7779e4c45155022556fc634f9
ToppCell	droplet-Spleen-nan-3m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN3A CD207 DNASE1L3 LRP8	2.38e-04	166	81	4	c1f18de4a1a2b6cdc703e6d29d136e1134fcbdf3
ToppCell	droplet-Limb_Muscle-nan-3m-Myeloid-chondrocyte-like\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUP210 PRKDC CLOCK XPOT	2.38e-04	166	81	4	35db3022c33d6f8bb6587d9eec89a7cccb70271a
ToppCell	droplet-Spleen-nan-3m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SCN3A CD207 DNASE1L3 LRP8	2.38e-04	166	81	4	94c30d6ca179d0cb02a5ed0093c5a2871e17ae50
ToppCell	droplet-Thymus-nan-21m-Myeloid-professional_antigen_presenting_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR137B ITGA8 APOE DNASE1L3	2.61e-04	170	81	4	29deb285d5a82c0abcc108012ca42f4b4b4d9e19
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-microglial_cell\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FER1L4 TLCD4 CD207 APOE	2.61e-04	170	81	4	626c12b9a51218f72ee32afb5fd5d4b075025d75
ToppCell	facs-Brain_Myeloid-Striatum-24m\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FER1L4 TLCD4 CD207 APOE	2.61e-04	170	81	4	31daac8696ae8c021c0302d3b30dd8194054b3e7
ToppCell	droplet-Thymus-nan-21m-Myeloid\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR137B ITGA8 APOE DNASE1L3	2.61e-04	170	81	4	dc35d66a9a9fe6cdd7f4ec0fe7efa49d02f2b5b2
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-nan\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FER1L4 TLCD4 CD207 APOE	2.61e-04	170	81	4	ca88dc0b7a6960facb7c4d3c0f4795431a0a43d2
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD207 GPR137B DNASE1L3 LRP8	2.61e-04	170	81	4	df1a34a69ae404c56f00751a01f52359535f5469
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FER1L4 TLCD4 CD207 APOE	2.61e-04	170	81	4	b6882665a27c78a63f3b4a2a8806c8438a98e407
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TLR10 CORO7 DYSF DNASE1L3	2.67e-04	171	81	4	1018d7bd378ce20bee56a77d5851b3538c55098c
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TLR10 CORO7 DYSF DNASE1L3	2.67e-04	171	81	4	6bda333bb751d7835a04f21ac959eea79f2516aa
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TLR10 CORO7 DYSF DNASE1L3	2.67e-04	171	81	4	173bb5318fdbaef6e695b6f9e3e0ff4a5432a1a4
ToppCell	343B-Fibroblasts-Fibroblast-H\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CHL1 TTLL12 TIGD7 UGT2B4	2.73e-04	172	81	4	eb199c279fe8a2551121db37e9556893197d33ff
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CHL1 PTPRK SCN3A CHD7	2.73e-04	172	81	4	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	343B-Fibroblasts-Fibroblast-H-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CHL1 TTLL12 TIGD7 UGT2B4	2.73e-04	172	81	4	709c6b77a7a52b873eefb6caca28a41291d384af
ToppCell	droplet-Lung-LUNG-30m-Myeloid-Myeloid_Dendritic_Type_2\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ESYT3 CD207 PLCB2 DNASE1L3	2.73e-04	172	81	4	a5344760b10ecdc0101f78b93b8fc0f8107068c5
ToppCell	droplet-Thymus-nan-3m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OTOF SCN3A CD207 DNASE1L3	2.79e-04	173	81	4	63f03abca84ae021ff34ff34537838aa8a1ccd11
ToppCell	367C-Epithelial_cells-Epithelial-I_(AT1)-\|367C / Donor, Lineage, Cell class and subclass (all cells)	ESYT3 MMP24 TLCD4 UGT2B7	2.85e-04	174	81	4	edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell	367C-Epithelial_cells-Epithelial-I_(AT1)\|367C / Donor, Lineage, Cell class and subclass (all cells)	ESYT3 MMP24 TLCD4 UGT2B7	2.85e-04	174	81	4	65539f69100db0b7d90b1b39ee15ab8281f86461
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	MMP24 HCN4 TLCD4 SCN2A	2.98e-04	176	81	4	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	facs-Brain_Myeloid-Striatum\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FER1L4 CD207 PLD1 APOE	3.04e-04	177	81	4	efb1990fd1d216f64261e81017299783afb24a1e
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-astrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 CD207 APOE LIX1	3.17e-04	179	81	4	7ae67e1c09a4ce9b3bcec4c48ee9cf2b1cb4e339
ToppCell	facs-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OTOF CD207 PLCB2 DNASE1L3	3.17e-04	179	81	4	55fde77dae7f9e7f3431c3185d14212a25af83df
ToppCell	3'_v3-Lung-Lymphocytic_B\|Lung / Manually curated celltypes from each tissue	TLR10 CHL1 PTPRK SCN3A	3.24e-04	180	81	4	237a2130a3f48595dad2417539c21e44585962b8
ToppCell	Severe-Myeloid-mDC\|Severe / Condition, Lineage, Cell class and cell subclass	TLR10 CD207 GPR137B DNASE1L3	3.31e-04	181	81	4	00f2949b609ac21bd2da6fd8f685739eeb2f48ad
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 LAMA1 UGT2B7 LIX1	3.31e-04	181	81	4	9d782ba5cf5a172cb4f447763fc50e5b13ef7dd9
ToppCell	Severe-Myeloid-mDC-\|Severe / Condition, Lineage, Cell class and cell subclass	TLR10 CD207 GPR137B DNASE1L3	3.31e-04	181	81	4	51ded98c76ec35ab1d24ac3ab98280381daa9831
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d14-21-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d14-21 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TLR10 PTPRK SCN3A LIX1	3.31e-04	181	81	4	0c52dd82e6b3dce3d6bb5c13501bf8383f7121e4
ToppCell	IIH-Treg-proli_CD4\|IIH / Condition, Cell_class and T cell subcluster	MTOR ARHGEF9 XRCC1 PCK2	3.38e-04	182	81	4	5c7d02da9ca2bca49db9832704b6894dfaa08a71
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A4_(IN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MMP24 OTOF HCN2 LRP8	3.38e-04	182	81	4	be32b5b8153c1053cbb55f1fccfa27c3ee97c1e1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 LAMA1 UGT2B7 LIX1	3.38e-04	182	81	4	eb138aa1dca9373f1586600f258df06dcf56d81f
ToppCell	facs-Aorta-Heart-3m-Myeloid-macrophage\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUP210 PLCB2 CORO7 DNASE1L3	3.38e-04	182	81	4	df26388c0c46d1c4775103c8e802937b4d4e7470
ToppCell	remission-B_naive\|World / disease stage, cell group and cell class	TLR10 PTPRK SCN3A CHD7	3.38e-04	182	81	4	cc1dfd2de35aee1a26f7efd78e108b60a3556ec5
ToppCell	10x5'-Lung-Lymphocytic_B\|Lung / Manually curated celltypes from each tissue	TLR10 CHL1 PTPRK DNASE1L3	3.38e-04	182	81	4	310f94437d197eaaaf6e30e68063b33e94befe77
ToppCell	10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell\|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TLR10 PTPRK SCN3A LIX1	3.45e-04	183	81	4	dbc7ec66da5930c2bf4e0405937b054e04c22a34
ToppCell	facs-Aorta-Heart-3m-Myeloid-leukocyte\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NUP210 PLCB2 CORO7 DNASE1L3	3.45e-04	183	81	4	062ec08d66c923f90fee771b1bf8d98bdc7e6c1b
ToppCell	PCW_07-8.5-Neuronal-Neuronal_postreplicative-neuro_neuronal_(6)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CHL1 CLVS2 SCN2A SCN3A	3.52e-04	184	81	4	571136c832cb8c08457744152231537aa8e8abd7
ToppCell	10x3'2.3-week_14-16-Myeloid_macrophage-stroma-osteoclast\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ESYT3 GPR137B EXT1 APOE	3.60e-04	185	81	4	5ed49b6d8214c6119355a6d3ee4e25d40bcc0c53
ToppCell	IPF-Myeloid-DC_Langerhans\|Myeloid / Disease state, Lineage and Cell class	TLR10 CHL1 CD207 GPR137B	3.60e-04	185	81	4	ced17f69486591c3cbbdc852a3e82c3f3a4a30d7
ToppCell	CF-Myeloid-cDC\|CF / Disease state, Lineage and Cell class	TRABD2A CD207 GPR137B DNASE1L3	3.60e-04	185	81	4	7f3d118845ff9f5f525796b0bbc6532a8ee323ab
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_type_2\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	OTOF CD207 PLCB2 DNASE1L3	3.60e-04	185	81	4	ed7b26bdebfd0df2b4f5020a855a052d94ae7219
ToppCell	proximal-3-Hematologic-Myeloid_Dendritic_Type_1\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TLR10 TRABD2A GPR137B DNASE1L3	3.67e-04	186	81	4	c920dffd24f051b54d8b48f801fffc928d99e135
ToppCell	droplet-Limb_Muscle-nan-24m-Macroglial-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHL1 CLVS2 ARHGEF9 HCN2	3.67e-04	186	81	4	adba5647a2feaba8e361dc1020d2f2dc4ce36b16
ToppCell	proximal-Hematologic-Myeloid_Dendritic_Type_1-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TLR10 TRABD2A GPR137B DNASE1L3	3.67e-04	186	81	4	d740aca5dc4240851ba7bc5988c0970d785ad0c2
ToppCell	343B-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PTPRK CETP DYSF DNASE1L3	3.67e-04	186	81	4	dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCell	5'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B2_(eMN)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HCN4 CLVS2 SCN3A LIX1	3.67e-04	186	81	4	24b23880d4ff8fb4a23e2012d5890b9e2fcf7283
ToppCell	343B-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	PTPRK CETP DYSF DNASE1L3	3.67e-04	186	81	4	080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCell	proximal-Hematologic-Myeloid_Dendritic_Type_1\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TLR10 TRABD2A GPR137B DNASE1L3	3.67e-04	186	81	4	4ca7f6c043874a0c536f75af5ca24c7c66725e54
ToppCell	Cerebellum-Neuronal\|Cerebellum / BrainAtlas - Mouse McCarroll V32	MMP24 HCN3 ARHGEF9 HAPLN4	3.75e-04	187	81	4	61b9d6eb131a674598aa8409d7fa909c8765442d
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 LAMA1 UGT2B7 LIX1	3.75e-04	187	81	4	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TLR10 PTPRK SCN3A LIX1	3.75e-04	187	81	4	d01926be1c8846a25fb6706e26b56b808b69f8f0
ToppCell	normal_Lymph_Node-Myeloid_cells-mo-Mac\|normal_Lymph_Node / Location, Cell class and cell subclass	CETP PLD1 APOE DYSF	3.82e-04	188	81	4	e83de94a9b47a6a90e98face887eae031a322af6
ToppCell	NS-critical-d_16-33-Myeloid-Monocyte-derived_DC\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CETP GPR137B APOE DNASE1L3	3.82e-04	188	81	4	08eb1e4b719af53c52895557523d0a1b7421d849
ToppCell	3'-Distal_airway-Immune_Myeloid-Dendritic\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TLR10 CD207 GPR137B DNASE1L3	3.82e-04	188	81	4	649d27b2ef735b481ec0ed4f7a9b39aacc472a78
ToppCell	PCW_07-8.5-Endothelial-Endothelial_mature-endo_bronchial_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CETP TNFRSF10A DYSF DNASE1L3	3.90e-04	189	81	4	4bc3826e0515b3cf2e2ef72a7b2cf9c32ade1812
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 LAMA1 UGT2B7 LIX1	3.98e-04	190	81	4	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	PBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TLR10 PTPRK SCN3A LIX1	3.98e-04	190	81	4	112706d64ee73b55dcf76f33ca064ab1fc6ce87f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CHL1 LAMA1 UGT2B7 LIX1	3.98e-04	190	81	4	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	COVID_vent-Lymphocytic-B_cell\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TLR10 PTPRK SCN3A CHD7	3.98e-04	190	81	4	40b5e9e8f8fd8d84cb5b43e67b49267082348e9f
ToppCell	COVID_vent-Lymphocytic-B_cell-\|COVID_vent / Disease condition, Lineage, Cell class and subclass	TLR10 PTPRK SCN3A CHD7	3.98e-04	190	81	4	a37a32dc1b931562a6660074e19d5598efc65284
ToppCell	Dendritic_cell\|World / shred by cell class for nasal brushing	TLR10 SCN3A CD207 APOE	3.98e-04	190	81	4	ae24934f45eea9c228bf6fe8cd0d6abca9eb208e
ToppCell	severe-B_naive\|severe / disease stage, cell group and cell class	TLR10 CHL1 PTPRK SCN3A	3.98e-04	190	81	4	2430a1fd18385305bf1b604747ff64026a8d5edf
ToppCell	Control-Lymphoid_B\|Control / Disease group, lineage and cell class	TLR10 PTPRK SCN3A CHD7	4.06e-04	191	81	4	0a760cd3a48c487ec899adb882fddea8914cfe0c
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TLR10 PTPRK SCN3A LIX1	4.06e-04	191	81	4	a831e30f37aff329d83fac9bdb84f783075d5df6
ToppCell	PCW_07-8.5-Endothelial-Endothelial_cycling-endo_proliferating1_(10)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	CETP TNFRSF10A DYSF DNASE1L3	4.06e-04	191	81	4	edfd5eeff69b5de19c5df3d899e42acd7e015913
Computational	Genes in the cancer module 236.	CETP APOE LRP8	6.11e-05	18	47	3	MODULE_236
Drug	HCNs	HCN4 HCN3 PRKDC HCN2	5.92e-07	20	78	4	CID006857665
Drug	UDP-N-acetylglucosamine	SLC17A5 STAM2 UGT2B4 UGT2B7 CTBS EXT1 EXTL2	6.25e-06	203	78	7	CID000001167
Drug	20-hydroxy-5,8,11,14-eicosatetraenoic acid	UGT2B7 PLD1 CLOCK	8.32e-06	12	78	3	ctd:C055987
Drug	JTP-25203	CETP APOE	1.16e-05	2	78	2	CID006918816
Disease	limb-girdle muscular dystrophy (implicated_via_orthology)	OTOF FER1L4 DYSF	5.05e-07	7	73	3	DOID:11724 (implicated_via_orthology)
Disease	Hypercholesterolemia, Familial	LDLRAP1 CETP APOE	1.15e-05	18	73	3	C0020445
Disease	Hypercholesterolemia	LDLRAP1 CETP APOE	1.25e-04	39	73	3	C0020443
Disease	esterified cholesterol measurement, intermediate density lipoprotein measurement	HAPLN4 APOE	1.67e-04	8	73	2	EFO_0008589, EFO_0008595
Disease	plasma clozapine-to-N-desmethylclozapine ratio measurement	UGT2B4 UGT2B7	2.15e-04	9	73	2	EFO_0600040
Disease	lactosyl-N-nervonoyl-sphingosine (d18:1/24:1) measurement	CETP CHD7	2.15e-04	9	73	2	EFO_0800517
Disease	generalized epilepsy with febrile seizures plus 2 (implicated_via_orthology)	SCN2A SCN3A	2.68e-04	10	73	2	DOID:0111294 (implicated_via_orthology)
Disease	Dravet syndrome (implicated_via_orthology)	SCN2A SCN3A	2.68e-04	10	73	2	DOID:0080422 (implicated_via_orthology)
Disease	Schizophrenia	CHL1 MTOR CLVS2 LAMA1 ITGA8 XRCC1 APOE CLOCK LRP8	3.23e-04	883	73	9	C0036341
Disease	generalized epilepsy with febrile seizures plus (implicated_via_orthology)	SCN2A SCN3A	3.92e-04	12	73	2	DOID:0060170 (implicated_via_orthology)
Disease	integral membrane protein 2B measurement	CETP APOE	3.92e-04	12	73	2	EFO_0802634
Disease	plasma beta-amyloid 1-42 measurement	XRCC1 APOE	4.63e-04	13	73	2	EFO_0005660
Disease	X-19141 measurement	UGT2B4 UGT2B7	4.63e-04	13	73	2	EFO_0800799
Disease	Hyperlipoproteinemia Type IIb	CETP APOE	4.63e-04	13	73	2	C1704417
Disease	gallbladder cancer (is_implicated_in)	XRCC1 APOE	4.63e-04	13	73	2	DOID:3121 (is_implicated_in)
Disease	cholesterol efflux capacity measurement	CETP APOE	5.39e-04	14	73	2	EFO_0009132
Disease	esterified cholesterol measurement, low density lipoprotein cholesterol measurement	HAPLN4 APOE	5.39e-04	14	73	2	EFO_0004611, EFO_0008589
Disease	Hyperlipoproteinemia Type IIa	CETP APOE	7.08e-04	16	73	2	C0745103
Disease	liver fat measurement, liver disease biomarker	APOE PCK2	7.08e-04	16	73	2	EFO_0006845, EFO_0010821
Disease	level of Sterol ester (27:1/18:0) in blood serum	CETP APOE	7.08e-04	16	73	2	OBA_2045196
Disease	epilepsy (implicated_via_orthology)	CHL1 SCN2A SCN3A SLC12A7	7.26e-04	163	73	4	DOID:1826 (implicated_via_orthology)
Disease	Lipidemias	CETP APOE	8.02e-04	17	73	2	C1706412
Disease	sphingomyelin 14:0 measurement	PAPOLA GPR137B	8.02e-04	17	73	2	EFO_0010390
Disease	cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	CETP APOE	8.02e-04	17	73	2	EFO_0022232
Disease	Hyperlipidemia	CETP APOE	8.02e-04	17	73	2	C0020473
Disease	Idiopathic hypogonadotropic hypogonadism	CHD7 IL17RD	9.00e-04	18	73	2	C0342384
Disease	very low density lipoprotein cholesterol measurement, esterified cholesterol measurement	CETP APOE	9.00e-04	18	73	2	EFO_0008317, EFO_0008589
Disease	schizophrenia (is_implicated_in)	CHL1 ITGA8 LRP8	9.67e-04	78	73	3	DOID:5419 (is_implicated_in)
Disease	esterified cholesterol measurement, high density lipoprotein cholesterol measurement	CETP APOE	1.00e-03	19	73	2	EFO_0004612, EFO_0008589
Disease	sodium-coupled monocarboxylate transporter 1 measurement	CETP APOE	1.00e-03	19	73	2	EFO_0802076
Disease	linoleic acid measurement	CETP FER1L4 HAPLN4 APOE	1.19e-03	186	73	4	EFO_0006807
Disease	free cholesterol to total lipids in chylomicrons and extremely large VLDL percentage	CETP HAPLN4	1.23e-03	21	73	2	EFO_0022277
Disease	cholesteryl esters to total lipids in chylomicrons and extremely large VLDL percentage	CETP APOE	1.23e-03	21	73	2	EFO_0022246
Disease	HMG CoA reductase inhibitor use measurement	CETP HAPLN4 UGT2B7 APOE	1.26e-03	189	73	4	EFO_0009932
Disease	intermediate density lipoprotein measurement	CETP HAPLN4 APOE	1.33e-03	87	73	3	EFO_0008595
Disease	anxiety disorder (implicated_via_orthology)	SCN2A SCN3A	1.35e-03	22	73	2	DOID:2030 (implicated_via_orthology)
Disease	X-24947 measurement	UGT2B4 UGT2B7	1.35e-03	22	73	2	EFO_0800910
Disease	visual epilepsy (biomarker_via_orthology)	PLD1 XRCC1 HCN2	1.46e-03	90	73	3	DOID:11832 (biomarker_via_orthology)
Disease	vitamin D measurement	CETP UGT2B4 HAPLN4 UGT2B7 APOE	1.48e-03	336	73	5	EFO_0004631
Disease	HDL cholesterol change measurement	CETP APOE	1.61e-03	24	73	2	EFO_0007805
Disease	Hepatolenticular Degeneration	ASMT APOE	1.61e-03	24	73	2	C0019202
Disease	Dyslipidemias	CETP APOE	1.61e-03	24	73	2	C0242339
Disease	Hepatic Form of Wilson Disease	ASMT APOE	1.61e-03	24	73	2	C1527352
Disease	Dyslipoproteinemias	CETP APOE	1.61e-03	24	73	2	C0598784
Disease	hearing impairment	OTOF CHD7 APOE	1.87e-03	98	73	3	C1384666
Disease	Kallmann Syndrome	CHD7 IL17RD	1.89e-03	26	73	2	C0162809
Disease	cholesterol to total lipids in small LDL percentage	CETP APOE	2.04e-03	27	73	2	EFO_0022241
Disease	Neurotoxicity Syndromes	TGM1 MTOR	2.35e-03	29	73	2	C0235032
Disease	Encephalopathy, Toxic	TGM1 MTOR	2.35e-03	29	73	2	C0149504
Disease	Toxic Encephalitis	TGM1 MTOR	2.35e-03	29	73	2	C0154659

Protein segments in the cluster

Peptide	Gene	Start	Entry
RYKTNEPVWEENFTF	ESYT2	576	A0FGR8
NKDPVWSQVFSFFVH	ESYT3	506	A0FGR9
EPGWIKQLFTNFISF	CETP	176	P11597
QAEAFQARLKSWFEP	APOE	271	P02649
ATWDLQPEKLDFTQF	CTIF	111	O43310
IPEVVWTAKQHFSFQ	ASMT	211	P46597
PDFEVFVFDVGQKTW	CTBS	56	Q01459
KQVNCFFSVFAVPWF	CST11	111	Q9H112
FGVIFDPVKQQFDWN	CHD7	1981	Q9P2D1
VFEFTEPKRSQSPFW	ARHGEF9	491	O43307
VAQAFKVAFEFWQVS	LDLRAP1	161	Q5SW96
WILEPSKFFQNVTAE	NUP210	671	Q8TEM1
AFDVWQKVTPLTFEE	MMP24	191	Q9Y5R2
DNYFTVTKPWFASQI	MTX3	116	Q5HYI7
QFIDEEPDWFEKQFV	IL17RD	551	Q8NFM7
FWAKVNKTVPSAFQF	MAGEB3	291	O15480
NKTVPSAFQFWYEEA	MAGEB3	296	O15480
EFFASPEAVVSWQKV	CHL1	446	O00533
TVLEPNTVSFNFKFW	MTMR6	481	Q9Y217
KTSFNWFVNPLKTFV	FER1L4	1736	A9Z1Z3
VFAFSVWQQFPDQIV	EXTL2	161	Q9UBQ6
EFFQDDVFPDTAVIW	CORO7	821	P57737
DTTQLFSLPKDFWEQ	PCK2	591	Q16822
KFPFSENQICLTFTW	PDCD6IP	81	Q8WUM4
KATLNPVWNETFVFN	PRKCG	216	P05129
TFFKEENSPPWIVFN	HCN3	116	Q9P1Z3
FFKDENTTPWIVFNV	HCN4	286	Q9Y3Q4
LGLAWFVFQQSEKFA	IKBIP	56	Q70UQ0
EPIEFKSNQWFGATV	ITGA8	126	P53708
EFWESKQQQKAAFPS	LIX1	36	Q8N485
KSAQLFFVVFEWKDP	PACC1	276	Q9H813
FFVVFEWKDPFIQKV	PACC1	281	Q9H813
AEWSKLFEAPNFFQK	PAPOLA	356	P51003
YVFSTKNWNTPIIFD	IFT80	356	Q9P2H3
DADVFSREPFVVWFQ	DNASE1L3	126	Q13609
DFAFTVWQSFPERIV	EXT1	576	Q16394
EKGIFWEPFANVTVE	C1orf112	766	Q9NSG2
SVNFKNILQWESPAF	IL10RB	31	Q08334
DITVFVPQWRFSKDA	KHNYN	476	O15037
WTKVVDPLAFTDVFV	HAPLN4	86	Q86UW8
DPFTLFNVFNAWVQV	DHX34	641	Q14147
QEDNPFSWKNFVDTV	SLC12A7	801	Q9Y666
AIFFTLFAKGEVQNW	SLC17A5	471	Q9NRA2
FHPEWFVSLFEQKTV	DYSF	1951	O75923
FKDETTAPWIVFNVV	HCN2	236	Q9UL51
PFGIAVFEDKVFWTD	LRP8	631	Q14114
FNTLVKWFEVDLPEN	OTOF	1181	Q9HC10
VSTFWPNEYQVIFEA	PTPRK	156	Q15262
QVQPFFDNIFVAVWD	MTOR	186	P42345
FDNIFVAVWDPKQAI	MTOR	191	P42345
SWTQQEQSPEKAFLF	MROH5	276	Q6ZUA9
KDFVAANSLSPFVFW	GPR137B	101	O60478
EFERIWEQFNPTKYT	PLD6	201	Q8N2A8
KSIFVLSPNFVQNEW	TLR10	691	Q9BXR5
FASEFFPRTWKQNFV	TMEM225B	96	P0DP42
NFVFKDWVQLDKPFA	PLD1	651	Q13393
EFQSFPKVFQKIWLE	SLC25A51	246	Q9H1U9
ENFWKYFNSVSEKPV	LAMA1	1291	P25391
SPFGENIKQIFQWIF	SPATA31A7	1161	Q8IWB4
VWEKFDPDATQFIEF	SCN3A	1796	Q9NY46
EFQSFPKVFQKIWLE	SLC25A52	246	Q3SY17
SPFFAEQLTAFQVWL	RPTOR	406	Q8N122
IRQDWKPTFLSNEEF	CLOCK	96	O15516
WVDDTPFNKVQSVRF	CD207	266	Q9UJ71
FFFKNVSILIPENWK	CLCA4	71	Q14CN2
NGFVLIIDWSNFTFK	CLVS2	156	Q5SYC1
SPFGENIKQIFQWIF	SPATA31A3	1161	Q5VYP0
FTQDFWPDQSIKDSF	ZNF99	81	A8MXY4
SPFGENIKQIFQWIF	SPATA31A5	1161	Q5VU36
PKDTFWSYFSQVQEI	UGT2B4	101	P06133
WFQSESPFTQKADFD	STPG3	146	Q8N7X2
SPFTQKADFDQEQKW	STPG3	151	Q8N7X2
VWEKFDPDATQFIEF	SCN2A	1801	Q99250
SSPFVNQRWFFEALK	TLCD4	151	Q96MV1
VWDFIPDNSKEAFLQ	TRABD2A	66	Q86V40
WSEEFQKDPQFSLIS	STAM2	116	O75886
PFIWVQVFAEPSNKE	nan	136	A1L4Q6
EFPWTDVQAEIFRAF	TTLL12	541	Q14166
TNSINPVWKEEPFVF	PLCB2	726	Q00722
LFFDKFANIVPFDSW	TNFRSF10A	366	O00220
EKQAEFFEPWVYSFS	PRKDC	636	P78527
FAQEFWPEQNIKDSF	ZNF675	81	Q8TD23
WPKFFFDILSVVDLN	XPOT	121	O43592
VQFVITAQEWDPSFE	XRCC1	581	P18887
TPFIFAEVNSDKVYW	TGM1	491	P22735
PKDTFWLYFSQVQEI	UGT2B7	101	P16662
LFSEWFFQNFVPEVR	TIGD7	261	Q6NT04