Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionpeptide binding

CACNA1B OGT MME ADNP PLOD1 TAP1 CEMIP

3.65e-05318587GO:0042277
DomainAcylCoA_DH/ox_N

ACADS ACOX1

7.23e-0413582IPR013786
Domain-

ACADS ACOX1

7.23e-04135821.10.540.10
DomainAcyl-CoA_Oxase/DH_cen-dom

ACADS ACOX1

9.70e-0415582IPR006091
DomainAcyl-CoA_dh_M

ACADS ACOX1

9.70e-0415582PF02770
DomainAcylCoA_DH/oxidase_NM_dom

ACADS ACOX1

9.70e-0415582IPR009100
DomainAcylCo_DH/oxidase_C

ACADS ACOX1

1.11e-0316582IPR009075
DomainWD40_repeat_CS

WDR36 EIF3I CFAP44 SEC31B

1.68e-03164584IPR019775
DomainTPR_REGION

OGT PRKDC KDM6A CLUH

1.72e-03165584PS50293
DomainTPR

OGT PRKDC KDM6A CLUH

1.72e-03165584PS50005
DomaincEGF

FBLN1 LRP1B

2.94e-0326582IPR026823
DomaincEGF

FBLN1 LRP1B

2.94e-0326582PF12662
Domain-

WDR36 EIF3I CFAP44 SEC31B PLXNB1

3.70e-033335852.130.10.10
DomainWD40/YVTN_repeat-like_dom

WDR36 EIF3I CFAP44 SEC31B PLXNB1

3.79e-03335585IPR015943
DomainTPR-like_helical_dom

OGT PRKDC KDM6A CLUH

5.91e-03233584IPR011990
DomainEGF_CA

FBLN1 EGFLAM LRP1B

6.46e-03122583SM00179
DomainEGF-like_Ca-bd_dom

FBLN1 EGFLAM LRP1B

6.76e-03124583IPR001881
DomainBTB-kelch_protein

KLHL15 KBTBD12

7.89e-0343582IPR017096
DomainWD40

WDR36 EIF3I CFAP44 SEC31B

8.53e-03259584PF00400
Pubmed

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.

SF3B1 WDR36 AP2A1 PRICKLE3 ANAPC1 GLI2 MARCHF5 ZNF283 MRPL27 PRKDC EIF3I PLOD1 TAP1 CLUH

7.97e-091203581429180619
Pubmed

Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.

PRKDC ITGA1

2.73e-06258212479823
Pubmed

Hedgehog signalling mediates drug resistance through targeting TAP1 in hepatocellular carcinoma.

GLI2 TAP1

8.19e-06358232108992
Pubmed

Normal hematopoiesis is maintained by activated bone marrow CD4+ T cells.

PRKDC TAP1

8.19e-06358215514013
Pubmed

KIAA1199, a deafness gene of unknown function, is a new hyaluronan binding protein involved in hyaluronan depolymerization.

AP2A1 CEMIP

8.19e-06358223509262
Pubmed

Folate-deficiency induced acyl-CoA synthetase short-chain family member 2 increases lysine crotonylome involved in neural tube defects.

ACADS ACOX1

8.19e-06358236743291
Pubmed

CEMIP, a novel adaptor protein of OGT, promotes colorectal cancer metastasis through glutamine metabolic reprogramming via reciprocal regulation of β-catenin.

OGT CEMIP

8.19e-06358234608265
Pubmed

Murine homologue of the human KIAA1199 is implicated in hyaluronan binding and depolymerization.

AP2A1 CEMIP

8.19e-06358224251095
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

SF3B1 WDR36 ANAPC1 PRKDC EIF3I ADNP PLOD1 CLUH

1.24e-0565358822586326
Pubmed

Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.

SF3B1 WDR36 AP2A1 PDP1 MARCHF5 PRKDC IDH1 EIF3I ADNP PLOD1 CLUH

1.38e-051367581132687490
Pubmed

The cancer driver genes IDH1/2, JARID1C/ KDM5C, and UTX/ KDM6A: crosstalk between histone demethylation and hypoxic reprogramming in cancer metabolism.

IDH1 KDM6A

1.64e-05458231221981
Pubmed

Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.

PRKDC TAP1

1.64e-05458224209604
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

FBLN1 OGT SF3B1 AP2A1 PRICKLE3 ANAPC1 PRKDC EIF3I PLOD1 NEURL4

1.92e-051155581020360068
Pubmed

N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.

TNIK STAM2 SF3B1 WDR36 ACACB PRKDC IDH1 EIF3I ADNP

2.29e-0593458933916271
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

WDR36 PRKDC EIF3I SRBD1 PLOD1

2.47e-0520658522174317
Pubmed

Mutant IDH Inhibits IFNγ-TET2 Signaling to Promote Immunoevasion and Tumor Maintenance in Cholangiocarcinoma.

PRKDC IDH1

2.72e-05558234848557
Pubmed

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function.

PRKDC TAP1

2.72e-05558236868208
Pubmed

PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.

OGT KDM6A

2.72e-05558234667079
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

OGT SF3B1 PRKDC ADNP KDM6A

3.38e-0522058535785414
Pubmed

A proteome-wide perspective on peroxisome targeting signal 1(PTS1)-Pex5p affinities.

ACOX1 HMGCL IDH1

5.55e-054458320178365
Pubmed

Mutational Hotspot of TET2, IDH1, IDH2, SRSF2, SF3B1, KRAS, and NRAS from Human Systemic Mastocytosis Are Not Conserved in Canine Mast Cell Tumors.

SF3B1 IDH1

5.71e-05758226562302
Pubmed

EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.

SF3B1 PRKDC ADNP PLXNB1

6.37e-0512858423858473
Pubmed

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair.

SF3B1 AP2A1 ANAPC1 DHX40 MRPL27 PRKDC EIF3I ADNP PLOD1 OPLAH

6.54e-051335581029229926
Pubmed

Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.

ACADS ACOX1 HMGCL IDH1

7.18e-0513258422496890
Pubmed

Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.

TNIK CACNA1B SF3B1 ACACB ACADS PRKCG HMGCL EIF3I LRP1B

1.06e-04113958936417873
Pubmed

The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.

WDR36 ANAPC1 EGFLAM EIF3I SRBD1

1.07e-0428158524163370
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

OGT SF3B1 WDR36 AP2A1 MRPL27 SRBD1 PLOD1

1.32e-0467858730209976
Pubmed

Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

ACACB ACADS PDP1 CHDH MRPL27 HMGCL IDH1 TAP1

1.45e-0492658820877624
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

TNIK OGT SF3B1 AP2A1 ANAPC1 PRKCG ADNP NEURL4

1.89e-0496358828671696
Pubmed

Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation.

PRKCG EGFLAM

2.11e-041358218641643
Pubmed

Defining the human deubiquitinating enzyme interaction landscape.

OGT WDR36 DHX40 KLHL15 USP4 EIF3I SRBD1 NEURL4

2.52e-04100558819615732
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

WDR36 AP2A1 ANAPC1 DHX40 ADNP NEURL4

2.60e-0453358630554943
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

OGT SF3B1 AP2A1 PRKDC ZNF606 SEC31B LRP1B KDM6A SEZ6L

2.60e-04128558935914814
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

OGT SF3B1 WDR36 ANAPC1 PRKDC EIF3I ADNP KDM6A

2.68e-04101458832416067
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

OGT SF3B1 WDR36 AP2A1 ANAPC1 PRKDC SRBD1 ADNP KDM6A

2.74e-04129458930804502
Pubmed

Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci.

PRKCG MME

2.83e-04155821460423
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

SF3B1 WDR36 AP2A1 PRKDC ADNP PLOD1 TAP1 NEURL4

2.86e-04102458824711643
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

STAM2 OGT ANAPC1 PRKDC ADNP KDM6A

3.04e-0454958638280479
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

OGT SF3B1 WDR36 AP2A1 ACACB PRKDC EIF3I ADNP PLOD1

3.13e-04131858930463901
Pubmed

The ubiquitin specific protease-4 (USP4) interacts with the S9/Rpn6 subunit of the proteasome.

USP4 PLOD1

3.23e-041658223022198
Pubmed

PICK1 interacts with ABP/GRIP to regulate AMPA receptor trafficking.

AP2A1 PRKCG

3.23e-041658216055064
Pubmed

Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.

OGT SF3B1 ACACB PRKDC ADNP

3.25e-0435758537059091
Pubmed

A mitochondrial protein compendium elucidates complex I disease biology.

ACACB ACADS PDP1 CHDH MRPL27 HMGCL IDH1 TAP1

3.32e-04104758818614015
Pubmed

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

OGT PRKDC

3.66e-041758220479123
Pubmed

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.

AP2A1 ACOX1 IDH1 EIF3I

3.67e-0420258433601422
Pubmed

EZH2 interacts with HP1BP3 to epigenetically activate WNT7B that promotes temozolomide resistance in glioblastoma.

AP2A1 ACADS PRKDC IDH1 EIF3I PLOD1 TAP1

3.68e-0480358736517590
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

SF3B1 WDR36 AP2A1 DHX40 PRKDC EIF3I SRBD1 ADNP PLOD1

3.80e-04135358929467282
Pubmed

The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module.

STAM2 AP2A1

4.11e-041858210567358
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

STAM2 OGT ANAPC1 DHX40 EIF3I CFAP44

4.37e-0458858638580884
Pubmed

Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development.

OPN1LW PRKCG

4.59e-041958220110327
Pubmed

Cooperative activity of noggin and gremlin 1 in axial skeleton development.

GLI2 PRKCG

4.59e-041958221303853
Pubmed

Biochemistry of mammalian peroxisomes revisited.

ACOX1 IDH1

5.09e-042058216756494
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

OGT KDM6A

5.09e-042058229785026
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PDP1 ACOX1 HMGCL MME IDH1 EIF3I PLOD1

5.50e-0485958731536960
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

SF3B1 WDR36 AP2A1 ANAPC1 HMGCL PRKDC EIF3I ADNP CLUH

5.52e-04142558930948266
Pubmed

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks.

OGT SF3B1 PRKDC EIF3I SRBD1 PLOD1

5.54e-0461558631048545
Pubmed

Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.

OGT SF3B1 PRKDC EIF3I PLOD1

5.96e-0440858533766124
Pubmed

METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.

AP2A1 CHDH PRKDC EIF3I

6.07e-0423158436597993
Pubmed

Transcription factor protein interactomes reveal genetic determinants in heart disease.

OGT SF3B1 AP2A1 PRKDC ADNP

6.16e-0441158535182466
Pubmed

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

KLHL15 VEPH1 FHDC1

6.72e-0410258311214970
Pubmed

Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line.

OPN1LW PRKCG

6.76e-042358226965927
Pubmed

Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.

GLI2 LRP1B

6.76e-042358220932654
Pubmed

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

SF3B1 AP2A1 PRKDC IDH1

7.45e-0424458428902428
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

AP2A1 ACACB ANAPC1 PRKDC PLOD1

8.89e-0444658524255178
Pubmed

TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.

SF3B1 EIF3I

1.00e-032858229653964
Pubmed

Homologous Transcription Factors DUX4 and DUX4c Associate with Cytoplasmic Proteins during Muscle Differentiation.

SF3B1 AP2A1 PRKDC EIF3I

1.10e-0327158426816005
Pubmed

Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.

OGT SF3B1 ANAPC1 PRKDC

1.11e-0327258431010829
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

OGT AP2A1 DHX40 ACP3 PRKDC PLOD1 CLUH

1.15e-0397458728675297
Pubmed

Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex.

OGT PRKDC

1.15e-033058216449650
Pubmed

HERC2 Facilitates BLM and WRN Helicase Complex Interaction with RPA to Suppress G-Quadruplex DNA.

EIF3I NEURL4

1.23e-033158230279242
Pubmed

The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci.

ITGA1 IDH1

1.23e-03315822165966
Pubmed

An Interaction Landscape of Ubiquitin Signaling.

STAM2 OGT AP2A1 USP4 NEURL4

1.24e-0348158528190767
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

SF3B1 WDR36 DHX40 PRKDC SRBD1 ADNP PLOD1

1.25e-0398958736424410
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

SF3B1 WDR36 PRKDC ADNP

1.29e-0328358430585729
Pubmed

Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.

WDR36 ANAPC1

1.31e-033258223817571
Pubmed

Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.

OPN1LW EGFLAM

1.31e-033258225757744
Pubmed

The functional interactome landscape of the human histone deacetylase family.

WDR36 PRKDC MME ADNP

1.39e-0328958423752268
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

OGT ANAPC1 KLHL15 ADNP KDM6A

1.41e-0349558527705803
Pubmed

BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.

OGT WDR36 ADNP

1.48e-0313458325452129
Pubmed

Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry.

SF3B1 PRKDC

1.48e-033458211101529
Pubmed

Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.

USP4 IDH1 EIF3I

1.57e-0313758337039823
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

WDR36 AP2A1 PRKDC EIF3I SRBD1 NEURL4

1.63e-0375958635915203
Cytoband2q33.3

PLEKHM3 IDH1

6.67e-04305822q33.3
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B MME LRP1B SORCS1

5.63e-05160584c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1B MME LRP1B SORCS1

5.63e-0516058425c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CACNA1B MME SEZ6L SORCS1

6.64e-051675843edb0570e583bb527165bcd8a4c25a042054043b
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

TNIK EGFLAM FHDC1 SORCS1

8.32e-0517758459726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellChildren_(3_yrs)|World / Lineage, Cell type, age group and donor

TNIK ACACB VEPH1 MME

8.51e-05178584df2ecd3214590b914f2762db57efe780ba038db3
ToppCellRA-11._Adipocyte|RA / Chamber and Cluster_Paper

ACACB MME IDH1 LRP1B

8.88e-05180584d48a3d27357f7d184132a6805950f93080146b59
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-alveolar_macrophage-Alveolar_macrophages-Alveolar_macrophages_L.1.0.5.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ACACB CHDH MME IFI6

9.47e-05183584103c4c4595d8daa677679fd2fa1e99cd398e56dd
ToppCellLA-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB MME IDH1 LRP1B

9.47e-05183584b177be283e1553fb1f69a346f1ba79ad00297fa2
ToppCellLA-11._Adipocyte|LA / Chamber and Cluster_Paper

ACACB MME IDH1 LRP1B

9.47e-051835843f9011976782fa8aa95cdd6f00f07a91094d411b
ToppCellfacs-Liver-Hepatocytes-24m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ACADS CHDH CLUH OPLAH

9.47e-05183584d0721c6aa426953a520d40e976b6e65aa7ca65e8
ToppCellTCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1|TCGA-Pancreas / Sample_Type by Project: Shred V9

TNIK STAM2 ZNF283 ITGA1

1.01e-0418658403db813598b67b1e08f759758a1c2023396921fa
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.03e-041875845c73010fe4c85fb5cc1273f5504821229ca0cc4b
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.03e-04187584dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.03e-0418758493c78fc7f126132eb84feb47be2c4e8c568b9e91
ToppCelldroplet-Fat-SCAT-30m-Epithelial|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHDH ACP3 SRBD1 PLXNB1

1.03e-041875845fada3c5a58c1890029ccbfff2608b33f8cd2df7
ToppCelldroplet-Fat-SCAT-30m-Epithelial-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHDH ACP3 SRBD1 PLXNB1

1.03e-04187584766e808138fc2cd623c2e6d57fcb5c7378da0e03
ToppCelldroplet-Fat-SCAT-30m-Epithelial-epithelial_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHDH ACP3 SRBD1 PLXNB1

1.03e-04187584f49d06600060deeb2fc1b1da5b93496535f20104
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.03e-04187584ae90c263f80c36a410150d499e268d198944a3d9
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

TNIK CHDH MME SORCS1

1.03e-04187584acd305475f3609800af0d7bc68d83ef41228080b
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.03e-041875845d3d68519c8e19f10c29f9d81712125be78ca15a
ToppCellRA-11._Adipocyte|World / Chamber and Cluster_Paper

ACACB MME IDH1 LRP1B

1.05e-041885844dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK CHDH MME SORCS1

1.07e-0418958413fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 GLI2 ACP3 MME

1.07e-041895846f0fc5271a7d3682f145e734abc3be6473dda2e2
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 GLI2 ITGA1 CEMIP

1.07e-0418958471397e993a77d70b2eeede240bdfc7660b558987
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 GLI2 ITGA1 CEMIP

1.07e-041895844eea4759520c312bd17a681034d8074e47093d2b
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TNIK CHDH MME SORCS1

1.07e-04189584204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellfacs-Brain_Non-Myeloid-Striatum_-18m-Epithelial-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FBLN1 GLI2 ACP3 MME

1.07e-041895843b9ce8964b16cb2200d30cbb0bfc711dcad2380e
ToppCellIPF-Myeloid-Macrophage_Alveolar|Myeloid / Disease state, Lineage and Cell class

ACACB ACOX1 GALNT12 MME

1.09e-041905842592765016f291565697265800a232b2edef3792
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.09e-041905845c64b727669b23d2a23c8ad1d5d6caab7af37d56
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.09e-041905843a55cc5dc2549788bfe55f649686887b21a1fdd2
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.09e-04190584b56c55f608b30f7379941ac7d5f0f5200f305fca
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Astro-Astrocyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.09e-041905841c3d601422efa60fad8565f9ccd9032b847e4a91
ToppCell5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SGSM1 CHDH FHDC1 IFI6

1.12e-0419158454f07e4de61735051498846afb44b1798bed8144
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro-Astrocyte|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.14e-04192584f7e4509003d71f805b9d4587098e90d2897b6739
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.14e-0419258443beaac1de99b9c1a6dab4a450b4e81286987b64
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Astro|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.14e-04192584705ce805cb00a53793b57bcf466d0fbec590a83c
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro-Astrocyte|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.16e-04193584b03d908d4b8940927f72c76a1b0f237d13f39056
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Astro|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FBLN1 ACACB GLI2 PLXNB1

1.16e-0419358440edc07b6e7f19f6ee885fa5af0b63ef1b0f2468
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TNIK GLI2 ITGA1 CEMIP

1.19e-0419458435f132cc38ac133be01834ed0946188aa0757eb4
ToppCellFetal_29-31_weeks-Mesenchymal-matrix_fibroblast_1_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TNIK FBLN1 GLI2 ITGA1

1.19e-04194584011e14d9ed1393275f892060e7708ffadcd0767f
ToppCellMild|World / Disease group and Cell class

ITGA1 IFI6 TAP1 KDM6A

1.23e-041965845e4ed4a5a437cfa002b92775992a791e27aa4c27
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 GLI2 ITGA1 CEMIP

1.26e-04197584ae0435f4b4a9cdedb1c201fc56921048390097bf
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FBLN1 GLI2 ITGA1 CEMIP

1.26e-0419758437f6b6f2809b952382eaebb642b0aad6371f4251
ToppCellSevere-CD8+_T_activated|Severe / Disease group and Cell class

OGT ITGA1 IFI6 TAP1

1.26e-04197584bb1e3e1d841c2c7141eb1099e7755860b168b6fc
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial-Astrocyte|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CHDH VEPH1 IDH1 SEZ6L

1.33e-04200584158ba898312c73bcb54c675a4860874a1dd58662
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Macroglial|GW26 / Sample Type, Dataset, Time_group, and Cell type.

CHDH VEPH1 IDH1 SEZ6L

1.33e-0420058446f99bed98da09e6d3f45d4443cbaa6b6c1589bb
Drughydroxyl radicals

AP2A1 ACADS ANAPC1 PDP1 ACOX1 CHDH ACP3 PRKCG USP4 MME IDH1 PLOD1 LRP1B OPLAH

4.97e-0613415814CID000000961
DrugMoxonidine [75438-57-2]; Down 200; 16.6uM; HL60; HT_HG-U133A

TNIK STAM2 FBLN1 ACADS SEC31B IFI6

1.05e-051965862923_DN
DrugPinacidil [85371-64-8]; Down 200; 16.4uM; PC3; HT_HG-U133A

TNIK STAM2 ACADS GALNT12 ITGA1 CFAP44

1.18e-052005866356_DN
DiseaseProstatic Neoplasms

FBLN1 SF3B1 PDP1 PRKDC MME IDH1 LRP1B TAP1 KDM6A

2.25e-06616569C0033578
DiseaseMalignant neoplasm of prostate

FBLN1 SF3B1 PDP1 PRKDC MME IDH1 LRP1B TAP1 KDM6A

2.25e-06616569C0376358
Diseaseinterleukin-17 receptor B measurement

CHDH PLOD1

7.38e-057562EFO_0801719
Diseaseepilepsy (implicated_via_orthology)

TNIK CACNA1B PRICKLE3 LRP1B

2.64e-04163564DOID:1826 (implicated_via_orthology)
Diseasemyelodysplastic syndrome (is_implicated_in)

SF3B1 IDH1

1.49e-0330562DOID:0050908 (is_implicated_in)
Diseasecolorectal cancer (is_implicated_in)

GALNT12 LRP1B KDM6A

1.59e-03121563DOID:9256 (is_implicated_in)
DiseaseR-warfarin measurement

TNIK CACNA1B GALNT12 MME

1.62e-03265564EFO_0803324

Protein segments in the cluster

PeptideGeneStartEntry
RIGYQVTAMIGHTNV

ADNP

246

Q9H2P0
NGALYVGGMKEIALH

EGFLAM

961

Q63HQ2
HQAIQILGGMGYVTE

ACADS

361

P16219
ACHENMVKVGGYILG

AP2A1

491

O95782
NAVMYHGIESQGGVS

CACNA1B

666

Q00975
GTELKHMGQQLVGQY

CEMIP

541

Q8WUJ3
HNGPINQIMLYEGEV

CFAP44

366

Q96MT7
QQEAYQVHVGPMRGT

CHDH

416

Q8NE62
IVNQVSGYFVLGHPM

OPN1LW

111

P04000
GGVQIMHYNGVSHIT

ACACB

1981

O00763
QVGGDMCVHAYLSGQ

ANAPC1

1861

Q9H1A4
HLVLQAGNIMNAGGY

FHDC1

296

Q9C0D6
EYPHIGRVGMDGTNQ

LRP1B

3151

Q9NZR2
YGIQALGGMLVESVH

ASMTL

176

O95671
HVGHTILGMNTVQLY

KDM6A

1121

O15550
GQHVQDVLGMVTVAG

PLXNB1

1096

O43157
LTGQMARIYGAVGHV

VEPH1

286

Q14D04
NSLNYGGIGMVIGHE

MME

571

P08473
LEQLLYGNHVVGSEM

NKIRAS2

21

Q9NYR9
YGAVTVMQVVGHKEG

MARCHF5

116

Q9NX47
IHMYEQDGGLENLGS

GLI2

1451

P10070
YVTGGDLMYHIQQLG

PRKCG

436

P05129
VVHAAVPGYMGRQNE

PLEKHM3

306

Q6ZWE6
HTGQVIIYRMEDGNI

ITGA1

461

P56199
IAVGGYKVTLGQMHG

PDP1

446

Q9P0J1
GGYENVPTIDIHMNQ

PLOD1

591

Q02809
GFGQLTQLGMEQHYE

ACP3

66

P15309
EHIGLDQGQMAYEGQ

PRICKLE3

316

O43900
LEMNYVVGGVVSHRN

FBLN1

676

P23142
QIIGTYAQTEMGHGT

ACOX1

131

Q15067
TYLVHNFEEGGGVAM

IDH1

166

O75874
DKQIMVLGGLCYNGH

KLHL15

541

Q96M94
YDHVVLGGGQEAMDV

EIF3I

241

Q13347
VVIGNIGALMGYATH

IFI6

106

P09912
GHQVILYLCHGMGQN

GALNT12

471

Q8IXK2
YEAGFSQHGMIGVTQ

DHX40

91

Q8IX18
LVEMGFHYVGQAGLE

C9orf85

161

Q96MD7
GNGVMHNGTTILDEY

NEURL4

611

Q96JN8
DGIHILVNMNGYTKG

OGT

631

O15294
GSIHNDLYVIGGQMK

KBTBD12

381

Q3ZCT8
GDEVMPHILGQYLGN

SEZ6L

686

Q9BYH1
IGQYGLDVVQAYMGH

OPLAH

941

O14841
LVYMLEGLGIHTGVN

HMGCL

281

P35914
LEFVGDGIYNNTMGH

TAP1

241

Q03518
GGDNGMLILYNVTHI

SEC31B

91

Q9NQW1
HIGVGMYQHDVSQTL

SRBD1

676

Q8N5C6
LDNNIGLVLHGVMEY

CLUH

1106

O75153
SNEQYNVGMVGTHGL

TNIK

871

Q9UKE5
DLIAVSNHYGAMGVG

USP4

866

Q13107
VVQHMSLGVYGFGCE

SF3B1

1191

O75533
GGNYMGQSIHQVTVA

STAM2

401

O75886
QHIEIGYVQGMCDLL

SGSM1

971

Q2NKQ1
NNGGEGIHYMVVEIV

PRKDC

2176

P78527
MEGHYVHAGNIIATQ

MRPL27

56

Q9P0M9
HSVLYLDQGGVLVAM

SORCS1

586

Q8WY21
MLETYGHLLSVGNQI

ZNF606

91

Q8WXB4
GLKGHQEGYFSQMII

ZNF283

166

Q8N7M2
GTVDVYNMQSGIHRG

WDR36

516

Q8NI36