Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainInt_alpha_beta-p

GPLD1 ITGA8 ITGA3

1.50e-0519483IPR013519
DomainInt_alpha

GPLD1 ITGA8 ITGA3

1.50e-0519483SM00191
DomainDistal-less_N

DLX3 DLX5

1.94e-053482IPR022135
DomainDLL_N

DLX3 DLX5

1.94e-053482PF12413
DomainFG_GAP

GPLD1 ITGA8 ITGA3

2.37e-0522483PS51470
DomainFG-GAP

GPLD1 ITGA8 ITGA3

3.10e-0524483PF01839
DomainFG-GAP

GPLD1 ITGA8 ITGA3

3.10e-0524483IPR013517
Domain-

HNRNPDL EWSR1 TAF15 HNRNPAB RBM20 NCBP3

3.62e-052444863.30.70.330
DomainREJ

PKD1L2 PKDREJ

3.87e-054482PS51111
DomainREJ_dom

PKD1L2 PKDREJ

3.87e-054482IPR014010
DomainNucleotide-bd_a/b_plait

HNRNPDL EWSR1 TAF15 HNRNPAB RBM20 NCBP3

4.95e-05258486IPR012677
DomainPKD_2

PKD1L2 PKDREJ

6.44e-055482IPR003915
DomainPKD/REJ-like

PKD1L2 PKDREJ

9.64e-056482IPR002859
DomainREJ

PKD1L2 PKDREJ

9.64e-056482PF02010
DomainRRM

HNRNPDL EWSR1 TAF15 HNRNPAB RBM20

2.31e-04217485SM00360
DomainRRM_dom

HNRNPDL EWSR1 TAF15 HNRNPAB RBM20

2.84e-04227485IPR000504
Domain-

EWSR1 TAF15

2.87e-04104824.10.1060.10
DomainRRM

HNRNPDL EWSR1 TAF15 HNRNPAB RBM20

3.02e-04230485PS50102
DomainPeptidase_S9

PREP ABHD17C

3.51e-0411482PF00326
DomainPKD_channel

PKD1L2 PKDREJ

3.51e-0411482PF08016
DomainPeptidase_S9

PREP ABHD17C

3.51e-0411482IPR001375
DomainPKD1_2_channel

PKD1L2 PKDREJ

3.51e-0411482IPR013122
DomainIntegrin_alpha_C_CS

ITGA8 ITGA3

7.58e-0416482IPR018184
DomainIntegrin_alpha-2

ITGA8 ITGA3

9.64e-0418482IPR013649
DomainIntegrin_alpha2

ITGA8 ITGA3

9.64e-0418482PF08441
DomainLH2

PKD1L2 PKDREJ

9.64e-0418482SM00308
DomainIntegrin_alpha

ITGA8 ITGA3

9.64e-0418482IPR000413
DomainINTEGRIN_ALPHA

ITGA8 ITGA3

9.64e-0418482PS00242
DomainPLAT

PKD1L2 PKDREJ

1.32e-0321482PS50095
Domain-

PKD1L2 PKDREJ

1.32e-03214822.60.60.20
DomainPLAT

PKD1L2 PKDREJ

1.32e-0321482PF01477
DomainPLAT/LH2_dom

PKD1L2 PKDREJ

1.32e-0321482IPR001024
Domainzf-RanBP

EWSR1 TAF15

1.45e-0322482PF00641
DomainZnF_RBZ

EWSR1 TAF15

1.58e-0323482SM00547
DomainZF_RANBP2_2

EWSR1 TAF15

1.58e-0323482PS50199
DomainZF_RANBP2_1

EWSR1 TAF15

1.72e-0324482PS01358
DomainZnf_RanBP2

EWSR1 TAF15

1.87e-0325482IPR001876
DomainIntegrin_dom

ITGA8 ITGA3

1.87e-0325482IPR032695
DomainRRM_1

HNRNPDL EWSR1 TAF15 HNRNPAB

1.98e-03208484PF00076
DomainFIBRINOGEN_C_1

CNTNAP5 FGG

3.05e-0332482PS00514
DomainFibrinogen_a/b/g_C_dom

CNTNAP5 FGG

3.05e-0332482IPR002181
DomainFIBRINOGEN_C_2

CNTNAP5 FGG

3.05e-0332482PS51406
DomainGPS

PKD1L2 PKDREJ

3.44e-0334482SM00303
DomainLaminin_EGF

LAMA3 PEAR1

3.65e-0335482PF00053
DomainEGF_Lam

LAMA3 PEAR1

3.65e-0335482SM00180
DomainGPS

PKD1L2 PKDREJ

4.07e-0337482IPR000203
DomainLAM_G_DOMAIN

CNTNAP5 LAMA3

4.29e-0338482PS50025
DomainLaminin_EGF

LAMA3 PEAR1

4.29e-0338482IPR002049
DomainLaminin_G_2

CNTNAP5 LAMA3

4.74e-0340482PF02210
DomainLamG

CNTNAP5 LAMA3

5.71e-0344482SM00282
PathwayPID_INTEGRIN1_PATHWAY

ITGA8 LAMA3 FGG ITGA3

1.25e-0566314M18
PathwayPID_UPA_UPAR_PATHWAY

GPLD1 FGG ITGA3

1.04e-0442313M174
Pubmed

Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.

HNRNPDL ILF3 DDX17 ZG16B EWSR1 TAF15 HNRNPAB

5.13e-0824449729884807
Pubmed

Identifying and quantifying in vivo methylation sites by heavy methyl SILAC.

ILF3 EWSR1 TAF15 HNRNPAB

9.27e-083049415782174
Pubmed

New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TUBGCP4 HNRNPAB NCBP3

2.55e-0746249831138677
Pubmed

EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes.

EWSR1 TAF15 TAF5

3.13e-07104939488465
Pubmed

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB GSN

5.45e-0734649725324306
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

HNRNPDL ARID1B ILF3 DDX17 CENPC EIF4G1 EWSR1 TAF15 HNRNPAB NCBP3

7.17e-07954491036373674
Pubmed

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme.

HNRNPDL ILF3 DDX17 CENPC FGG TAF5 HNRNPAB

1.21e-0639049717643375
Pubmed

Identification of proteins associated with ligand-activated estrogen receptor α in human breast cancer cell nuclei by tandem affinity purification and nano LC-MS/MS.

DDX17 EIF4G1 EWSR1 TF HNRNPAB GSN

1.25e-0624549621182205
Pubmed

Identifying biological pathways that underlie primordial short stature using network analysis.

HNRNPDL ILF3 DDX17 SACS EIF4G1 EWSR1 TAF15 HNRNPAB GSN NCBP3

1.36e-061024491024711643
Pubmed

SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 HNRNPAB

1.68e-0625849637794589
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 HNRNPAB

1.76e-0626049636199071
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB NCBP3

1.93e-0660549828977666
Pubmed

Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis.

EWSR1 TAF15

1.94e-06249222454397
Pubmed

Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins.

EWSR1 TAF15

1.94e-0624928954779
Pubmed

A cell signal pathway involving laminin-5, alpha3beta1 integrin, and mitogen-activated protein kinase can regulate epithelial cell proliferation.

LAMA3 ITGA3

1.94e-0624929950675
Pubmed

Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.

HNRNPDL ILF3 DDX17 EWSR1 TAF15 FGG HNRNPAB

2.01e-0642149734650049
Pubmed

TRIM28-mediated nucleocapsid protein SUMOylation enhances SARS-CoV-2 virulence.

HNRNPDL ILF3 DDX17 EWSR1 TAF15 FGG HNRNPAB

2.31e-0643049738172120
Pubmed

mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.

ILF3 DDX17 EIF4G1 EWSR1 HNRNPAB NCBP3

2.38e-0627449634244482
Pubmed

Proteomic analysis of the cullin 4B interactome using proximity-dependent biotinylation in living cells.

HNRNPDL ILF3 DDX17 EWSR1 TAF15

2.52e-0615349528225217
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

HNRNPDL ARID1B ILF3 DDX17 CENPC EIF4G1 TAF15 TUBGCP4 TF HNRNPAB

3.97e-061155491020360068
Pubmed

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.

HNRNPDL DDX17 HNRNPAB

3.97e-062249326420826
Pubmed

PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB GSN

4.46e-0667849830209976
Pubmed

FET family fusion oncoproteins target the SWI/SNF chromatin remodeling complex.

ARID1B EWSR1 TAF15

4.56e-062349330962207
Pubmed

EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.

HNRNPDL DDX17 ZG16B EWSR1 GSN

4.72e-0617449535031058
Pubmed

TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions.

HNRNPDL ARID1B DDX17 CENPC CCDC34 EIF4G1 EWSR1 HNRNPAB ABHD17C

4.93e-0692249927609421
Pubmed

CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB

5.73e-0649449726831064
Pubmed

The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.

EWSR1 TAF15

5.83e-06349218620564
Pubmed

Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia.

EWSR1 TAF15

5.83e-06349212359745
Pubmed

mRNA and protein levels of FUS, EWSR1, and TAF15 are upregulated in liposarcoma.

EWSR1 TAF15

5.83e-06349221344536
Pubmed

Sequence variants in DLX5, HOXD13 and 445 kb-microduplication surrounding BTRC cause split-hand/foot malformation in three different families.

HOXD13 DLX5

5.83e-06349237776184
Pubmed

EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma.

HOXD13 EWSR1

5.83e-06349235653119
Pubmed

A conserved N-terminal motif is required for complex formation between FUS, EWSR1, TAF15 and their oncogenic fusion proteins.

EWSR1 TAF15

5.83e-06349223975937
Pubmed

Aggregation of FET Proteins as a Pathological Change in Amyotrophic Lateral Sclerosis.

EWSR1 TAF15

5.83e-06349227311318
Pubmed

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.

EWSR1 TAF15

5.83e-06349221856723
Pubmed

Role of FET proteins in neurodegenerative disorders.

EWSR1 TAF15

5.83e-06349227415968
Pubmed

NR4A3 fusion proteins trigger an axon guidance switch that marks the difference between EWSR1 and TAF15 translocated extraskeletal myxoid chondrosarcomas.

EWSR1 TAF15

5.83e-06349231020999
Pubmed

O-GlcNAc glycosylation stoichiometry of the FET protein family: only EWS is glycosylated with a high stoichiometry.

EWSR1 TAF15

5.83e-06349227903134
Pubmed

Characterization of a new brain-specific isoform of the EWS oncoprotein.

EWSR1 TAF15

5.83e-06349211422378
Pubmed

Gene expression responses to FUS, EWS, and TAF15 reduction and stress granule sequestration analyses identifies FET-protein non-redundant functions.

EWSR1 TAF15

5.83e-06349223049996
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

HNRNPDL ILF3 DDX17 EIF4G1 TAF15 HNRNPAB GSN NCBP3

6.44e-0671349829802200
Pubmed

Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15.

HNRNPDL ILF3 DDX17 EIF4G1 SHMT1 HNRNPAB GSN NCBP3

6.51e-0671449828302793
Pubmed

Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.

HNRNPDL ARID1B ILF3 DDX17 KCNA10 SHMT1 TAF5 HNRNPAB

7.65e-0673049834857952
Pubmed

ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB

7.66e-0633649631253590
Pubmed

PRP19 transforms into a sensor of RPA-ssDNA after DNA damage and drives ATR activation via a ubiquitin-mediated circuitry.

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB

8.20e-0634049624332808
Pubmed

Interactomic analysis of REST/NRSF and implications of its functional links with the transcription suppressor TRIM28 during neuronal differentiation.

ILF3 DDX17 EWSR1 TAF15 HNRNPAB

1.05e-0520549527976729
Pubmed

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production.

HNRNPDL ILF3 DDX17 EWSR1 HNRNPAB

1.07e-0520649522174317
Pubmed

Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB

1.16e-0555149734728620
Pubmed

Post-transcriptional regulation of FUS and EWS protein expression by miR-141 during neural differentiation.

EWSR1 TAF15

1.16e-05449228453628
Pubmed

Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

DLX3 DLX5

1.16e-05449215456894
Pubmed

BMP2 commitment to the osteogenic lineage involves activation of Runx2 by DLX3 and a homeodomain transcriptional network.

DLX3 DLX5

1.16e-05449217060321
Pubmed

Human mast cells adhere to and migrate on epithelial and vascular basement membrane laminins LM-332 and LM-511 via alpha3beta1 integrin.

LAMA3 ITGA3

1.16e-05449219752234
Pubmed

Structural requirement of carboxyl-terminal globular domains of laminin alpha 3 chain for promotion of rapid cell adhesion and migration by laminin-5.

LAMA3 ITGA3

1.16e-05449210801807
Pubmed

The neurodegenerative diseases ALS and SMA are linked at the molecular level via the ASC-1 complex.

EWSR1 TAF15

1.16e-05449230398641
Pubmed

The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription.

EWSR1 TAF15

1.16e-0544929660765
Pubmed

The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3.

HNRNPDL ILF3 DDX17 EWSR1 TF HNRNPAB GSN

1.18e-0555249736293380
Pubmed

BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.

HNRNPDL ILF3 DDX17 EIF4G1 ATL3 EWSR1 TAF15 TAF5 TF HNRNPAB

1.26e-051318491030463901
Pubmed

Regulation of endodermal differentiation of human embryonic stem cells through integrin-ECM interactions.

ITGA8 LAMA3 ITGA3

1.27e-053249323154389
Pubmed

Characterization of molecules binding to the 70K N-terminal region of fibronectin by IFAST purification coupled with mass spectrometry.

FGG TF GSN

1.27e-053249323750785
Pubmed

Distinct roles and regulations for HoxD genes in metanephric kidney development.

HOXD13 ITGA8 ITGA3

1.39e-053349318159948
Pubmed

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

HNRNPDL ILF3 DDX17 EIF4G1 HNRNPAB

1.57e-0522349520020773
Pubmed

Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 TAF5 HNRNPAB

1.61e-0580949832129710
Pubmed

Recombinant human laminin-5 domains. Effects of heterotrimerization, proteolytic processing, and N-glycosylation on alpha3beta1 integrin binding.

LAMA3 ITGA3

1.94e-05549214612440
Pubmed

The evolution of the vertebrate Dlx gene family.

DLX3 DLX5

1.94e-0554928855272
Pubmed

Gene expression of runx2, Osterix, c-fos, DLX-3, DLX-5, and MSX-2 in dental follicle cells during osteogenic differentiation in vitro.

DLX3 DLX5

1.94e-05549216467978
Pubmed

Role of the Dlx homeobox genes in proximodistal patterning of the branchial arches: mutations of Dlx-1, Dlx-2, and Dlx-1 and -2 alter morphogenesis of proximal skeletal and soft tissue structures derived from the first and second arches.

DLX3 DLX5

1.94e-0554929187081
Pubmed

Cre recombinase-regulated Endothelin1 transgenic mouse lines: novel tools for analysis of embryonic and adult disorders.

DLX3 DLX5

1.94e-05549225725491
Pubmed

Study of FOXO1-interacting proteins using TurboID-based proximity labeling technology.

ZG16B TAF15 FGG TF HNRNPAB

2.37e-0524349536964488
Pubmed

Cellular RNA binding proteins NS1-BP and hnRNP K regulate influenza A virus RNA splicing.

ILF3 DDX17 HNRNPAB

2.50e-054049323825951
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

ILF3 DDX17 SACS EIF4G1 EWSR1 TAF15 FGG TF HNRNPAB GSN

2.56e-051431491037142655
Pubmed

Arginine methylation of SARS-Cov-2 nucleocapsid protein regulates RNA binding, its ability to suppress stress granule formation, and viral replication.

HNRNPDL ILF3 EWSR1 HNRNPAB

2.62e-0512149434029587
Pubmed

Tumor suppressor BAP1 nuclear import is governed by transportin-1.

HNRNPDL ILF3 DDX17 PREP EIF4G1 SHMT1 EWSR1 HNRNPAB GSN

2.84e-05114949935446349
Pubmed

Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription.

EWSR1 TAF15

2.91e-05649218509338
Pubmed

Expression of Dlx genes during the development of the murine dentition.

DLX3 DLX5

2.91e-05649211180832
Pubmed

Differential expression of orthologous Dlx genes in zebrafish and mice: implications for the evolution of the Dlx homeobox gene family.

DLX3 DLX5

2.91e-05649211069141
Pubmed

The hnRNP RALY regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization.

EWSR1 TAF15

2.91e-05649230354839
Pubmed

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

HNRNPDL DDX17 EWSR1 PKDREJ HNRNPAB

3.04e-0525649524189400
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

HNRNPDL ILF3 DDX17 EIF4G1 TAF15 HNRNPAB

3.54e-0544149631239290
Pubmed

Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.

ILF3 DDX17 EWSR1 GSN

3.57e-0513149434551306
Pubmed

ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.

HNRNPDL ILF3 DDX17 EIF4G1 HNRNPAB GSN NCBP3

3.69e-0566049732780723
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

ILF3 DDX17 EIF4G1 ATL3 GSN

3.78e-0526849533024031
Pubmed

ZF21 is a new regulator of focal adhesion disassembly and a potential member of the spreading initiation center.

DDX17 EWSR1 TAF15

3.82e-054649320890123
Pubmed

Homeobox gene Dlx3 is regulated by p63 during ectoderm development: relevance in the pathogenesis of ectodermal dysplasias.

DLX3 DLX5

4.07e-05749217164413
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

HNRNPDL ARID1B ILF3 EWSR1 TAF15 HNRNPAB

4.11e-0545349629656893
Pubmed

Landscape of the SOX2 protein-protein interactome.

ILF3 DDX17 EWSR1 TAF15

4.13e-0513649421280222
Pubmed

Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network.

HNRNPDL ILF3 DDX17 HNRNPAB

4.13e-0513649426979993
Pubmed

Interactome analysis of the human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein.

ILF3 DDX17 EIF4G1 HNRNPAB

4.38e-0513849430320910
Pubmed

Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.

ARID1B DDX17 EWSR1 TAF15 HNRNPAB

4.90e-0528349528533407
Pubmed

A novel role for the peptidyl-prolyl cis-trans isomerase Cyclophilin A in DNA-repair following replication fork stalling via the MRE11-RAD50-NBS1 complex.

HNRNPDL ARID1B ILF3 PREP HNRNPAB NCBP3

5.16e-0547249638943005
Pubmed

Generation of regionally specified neurons in expanded glial cultures derived from the mouse and human lateral ganglionic eminence.

DLX3 DLX5

5.42e-05849211358480
Pubmed

Roles for Msx and Dlx homeoproteins in vertebrate development.

DLX3 DLX5

5.42e-05849210773441
Pubmed

Elucidating timing and function of endothelin-A receptor signaling during craniofacial development using neural crest cell-specific gene deletion and receptor antagonism.

DLX3 DLX5

5.42e-05849219185569
Pubmed

Hepatocyte growth factor activator inhibitor-1 (HAI-1) is essential for the integrity of basement membranes in the developing placental labyrinth.

DLX3 ST14

5.42e-05849217174946
Pubmed

Spatial and temporal control of laminin-332 and -511 expressions during hair morphogenesis.

LAMA3 ITGA3

5.42e-05849223529140
Pubmed

Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.

HNRNPDL ILF3 HNRNPAB

5.53e-055249324591637
Pubmed

Mutual regulation between OGT and XIAP to control colon cancer cell growth and invasion.

HNRNPDL ILF3 DDX17 ATL3 EWSR1 TAF15 HNRNPAB

5.55e-0570449732994395
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

HNRNPDL YIPF5 ILF3 DDX17 EIF4G1 LAMA3 EWSR1 HNRNPAB GSN

5.70e-05125749936526897
Pubmed

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.

HNRNPDL YIPF5 ILF3 DDX17 EIF4G1 SHMT1 EWSR1 TAF15 HNRNPAB

5.70e-05125749937317656
Pubmed

BPA modulates the WDR5/TET2 complex to regulate ERβ expression in eutopic endometrium and drives the development of endometriosis.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB

5.90e-0571149733022573
Pubmed

Systematic Determination of Human Cyclin Dependent Kinase (CDK)-9 Interactome Identifies Novel Functions in RNA Splicing Mediated by the DEAD Box (DDX)-5/17 RNA Helicases.

ILF3 DDX17 EIF4G1 EWSR1 GSN

5.96e-0529549526209609
Pubmed

Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 HNRNPAB

6.07e-0548649630940648
InteractionTAF15 interactions

HNRNPDL ILF3 DDX17 PREP ZG16B EWSR1 TAF15 TAF5 HNRNPAB

4.36e-07408489int:TAF15
InteractionFN1 interactions

HNRNPDL RHBDD1 ILF3 DDX17 EIF4G1 ITGA8 EWSR1 FGG ITGA3 TF HNRNPAB GSN

4.90e-078484812int:FN1
InteractionKHDRBS2 interactions

HNRNPDL ILF3 DDX17 EWSR1 FGG

1.37e-05129485int:KHDRBS2
InteractionFOXC1 interactions

ILF3 DDX17 HOXD13 EWSR1 DLX5 GSN

1.62e-05228486int:FOXC1
InteractionSNRNP40 interactions

HNRNPDL ARID1B ILF3 DDX17 CENPC EWSR1 TAF15 HNRNPAB RBM20

1.66e-05637489int:SNRNP40
InteractionFOXO1 interactions

HOXD13 ZG16B TAF15 DLX5 FGG TF HNRNPAB

1.69e-05347487int:FOXO1
InteractionHNRNPDL interactions

HNRNPDL ILF3 DDX17 PREP EWSR1 TAF15 HNRNPAB

2.30e-05364487int:HNRNPDL
InteractionSOX7 interactions

ARID1B HOXD13 EWSR1 RBM20

4.32e-0582484int:SOX7
InteractionCELF1 interactions

HNRNPDL ILF3 EWSR1 TAF15 HNRNPAB RBM20

5.99e-05288486int:CELF1
InteractionSNRPC interactions

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB NCBP3

7.66e-05440487int:SNRPC
InteractionTRIM31 interactions

HNRNPDL ILF3 DDX17 EWSR1 TAF15 FGG HNRNPAB

9.32e-05454487int:TRIM31
InteractionARIH2 interactions

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB

9.65e-05314486int:ARIH2
InteractionSMC5 interactions

HNRNPDL ARID1B ILF3 DDX17 CENPC EIF4G1 EWSR1 TAF15 HNRNPAB NCBP3

1.01e-0410004810int:SMC5
InteractionGLDC interactions

ILF3 DDX17 EIF4G1 EWSR1 HNRNPAB NCBP3

1.09e-04321486int:GLDC
InteractionSRPK1 interactions

HNRNPDL ILF3 DDX17 ZG16B EWSR1 TAF15 TF

1.27e-04477487int:SRPK1
InteractionRBM45 interactions

HNRNPDL ILF3 DDX17 EWSR1 HNRNPAB

1.30e-04207485int:RBM45
InteractionSNRPA interactions

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB NCBP3

1.35e-04482487int:SNRPA
InteractionMCAT interactions

HNRNPDL SHMT1 EWSR1 TAF5

1.56e-04114484int:MCAT
InteractionRC3H2 interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB GSN

1.62e-04667488int:RC3H2
InteractionSCARNA22 interactions

ILF3 DDX17 EWSR1 HNRNPAB

1.78e-04118484int:SCARNA22
InteractionHNRNPA3 interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB

1.93e-04511487int:HNRNPA3
InteractionCHRNB3 interactions

ZG16B HNRNPAB

1.98e-049482int:CHRNB3
InteractionSNRPB interactions

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB NCBP3

2.08e-04517487int:SNRPB
InteractionTARDBP interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB

2.15e-04520487int:TARDBP
InteractionSRSF3 interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 NCBP3

2.20e-04522487int:SRSF3
InteractionGNG8 interactions

ZG16B FGG TF GSN

2.22e-04125484int:GNG8
InteractionCPSF6 interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 NCBP3

2.31e-04526487int:CPSF6
InteractionPHB1 interactions

HNRNPDL YIPF5 ILF3 DDX17 EIF4G1 ATL3 EWSR1 TAF15 HNRNPAB ST14

2.61e-0411234810int:PHB1
InteractionCUL4B interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB NCBP3

2.93e-04728488int:CUL4B
InteractionNEDD8 interactions

HNRNPDL ILF3 DDX17 EWSR1 TAF15 HNRNPAB

3.25e-04393486int:NEDD8
InteractionHNRNPA1 interactions

HNRNPDL ILF3 DDX17 CENPC EWSR1 TAF15 HNRNPAB RBM20 GSN

3.40e-04945489int:HNRNPA1
InteractionIL7R interactions

HNRNPDL ILF3 LAMA3 HNRNPAB

3.52e-04141484int:IL7R
InteractionTNIP2 interactions

HNRNPDL ARID1B DDX17 CENPC CCDC34 EIF4G1 EWSR1 HNRNPAB ABHD17C

3.59e-04952489int:TNIP2
InteractionCHD3 interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB NCBP3

3.80e-04757488int:CHD3
InteractionDAZL interactions

HNRNPDL ILF3 TAF15 RBM20

3.91e-04145484int:DAZL
InteractionSTX17 interactions

VWA5A PREP FGG TF GSN

4.08e-04265485int:STX17
InteractionFLI1 interactions

ARID1B EWSR1 TAF15

4.35e-0462483int:FLI1
InteractionSNRNP70 interactions

HNRNPDL ILF3 DDX17 EIF4G1 EWSR1 TAF15 HNRNPAB GSN NCBP3

4.57e-04984489int:SNRNP70
InteractionCUL2 interactions

HNRNPDL ARID1B ILF3 DDX17 EWSR1 TAF15 HNRNPAB

4.67e-04591487int:CUL2
InteractionREST interactions

ILF3 DDX17 EWSR1 TAF15 HNRNPAB

4.76e-04274485int:REST
InteractionIFIT2 interactions

HNRNPDL ILF3 HNRNPAB

4.77e-0464483int:IFIT2
InteractionDCUN1D1 interactions

HNRNPDL ILF3 EWSR1 TAF15 HNRNPAB

4.84e-04275485int:DCUN1D1
GeneFamilyRNA binding motif containing

HNRNPDL EWSR1 TAF15 HNRNPAB RBM20

1.71e-05213285725
GeneFamilyCD molecules|Integrin alpha subunits

ITGA8 ITGA3

3.48e-04182821160
GeneFamilyZinc fingers RANBP2-type |RNA binding motif containing

EWSR1 TAF15

4.77e-042128289
GeneFamilyNKL subclass homeoboxes and pseudogenes

DLX3 DLX5

4.81e-0367282519
ToppCellfacs-Skin-Anagen|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIDT2 FGG HNRNPAB GSN ABHD17C

2.04e-06189495adbfc723130079b4caf551f66d2aee86fab1903c
ToppCell(04)_Pre-ciliated-(2)_48hpi|(04)_Pre-ciliated / shred by cell type and Timepoint

EIF4G1 ATL3 SHMT1 GSN

2.81e-05159494e1f36b237e314ef6a18224eb8f3b97a612c39506
ToppCellTCGA-Adrenal-Primary_Tumor-Adrenocortical_carcinoma-Usual_Type-6|TCGA-Adrenal / Sample_Type by Project: Shred V9

USP2 BCO2 PKD1L2 SPAG17

3.02e-051624940e8fb83acb8ea9905cc3ca985feb8a00931549ff
ToppCellICU-NoSEP-Lymphocyte-T_NK-MAIT|ICU-NoSEP / Disease, Lineage and Cell Type

BCO2 SHMT1 ITGA3 NXPE3

3.33e-05166494d3fa2e42497201f1ca57f4f977fbaa0def950033
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

USP2 CNTNAP5 SPAG17 MORN3

3.73e-051714941854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCelldroplet-Lung-30m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ILF3 HLA-DOA SHMT1 TUBGCP4

3.82e-05172494b043d4f81dced7fb3326043f68474123be47cc5d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

VWA5A ITGA8 RBM20 ST14

4.18e-05176494ed421d8525108d2f585265d2cf777f07b29f44f0
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZG16B ST14 GSN ABHD17C

4.46e-05179494c833ded1f9e87be2ba2037820d92a389560b711c
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DLX3 DLX5 TF RBM20

4.66e-0518149447dce04db3392333eb2f7b9b24c32e6740d2d02f
ToppCell10x3'2.3-week_12-13-Mesenchymal_myocytic-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

DLX3 DLX5 TF RBM20

4.66e-0518149419103221c3a5a16b16378348004b2c50caee4f01
ToppCell10x3'2.3-week_14-16-Mesenchymal_myocytic-stroma-muscle_stem_cell|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

ITGA8 DLX3 DLX5 TF

5.40e-05188494de6f4889e0c5f39fbbaefd85526f645c6afa09d5
ToppCellfacs-Skin-Anagen-3m-Epithelial|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIDT2 FGG HNRNPAB GSN

5.63e-05190494888ded899f0513d41bf655896d59ae8ef74e0978
ToppCellfacs-Skin-Anagen-3m|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SIDT2 FGG HNRNPAB GSN

5.63e-051904943466cebab16964e94da130d0673fa32e7d90b5ed
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

ITGA8 DLX3 DLX5 TF

5.74e-0519149498b907f8fa024cf32e462323b782c5a371327bbd
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAK CCDC34 SPAG17 MORN3

5.74e-05191494e8d56e9f43943e9cc4dce83f2c234f19c2dd487d
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

MAK CCDC34 SPAG17 MORN3

5.74e-0519149452e8d7dfaf1ebb6df8bf3a1f4546af59faa67657
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZG16B ST14 GSN ABHD17C

6.22e-05195494c5f33b420c9ac14dc67fea632b8c2bc2442cbf3d
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-goblet-Goblet_cell|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ZG16B ST14 GSN ABHD17C

6.22e-05195494219c5d0cde7f6082755154f54db221413ec555cb
ToppCell10x5'v1-week_17-19-Mesenchymal_osteo-stroma-osteoblast_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

ITGA8 DLX3 DLX5 TF

6.35e-0519649457df2a57b35be9851ac0b1e5731baa53052511f0
ToppCellILEUM-non-inflamed-(6)_ILC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

BCO2 VWA5A ZG16B GSN

6.47e-0519749476a233eb9611d24b9bb9f4359c26606332a3c29e
ToppCellSepsis-ICU-NoSEP-Lymphocyte-T/NK-MAIT|ICU-NoSEP / Disease, condition lineage and cell class

BCO2 SHMT1 ITGA3 NXPE3

6.86e-052004944f03b5f4110ed1637ffe17cb6ff309265a3af9a8
Drug3-amino-9-ethylcarbazole

DLX3 DLX5 ITGA3 TF HNRNPAB

1.60e-0692495CID000008588
Diseaseamyotrophic lateral sclerosis type 6 (implicated_via_orthology)

EWSR1 TAF15

8.10e-063492DOID:0060198 (implicated_via_orthology)
DiseaseExtraskeletal Myxoid Chondrosarcoma

EWSR1 TAF15

2.69e-055492C1275278
DiseaseJunctional Epidermolysis Bullosa

LAMA3 ITGA3

4.04e-056492C0079301
DiseaseParatuberculosis

TF GSN

4.04e-056492C0030524
Diseaseautosomal dominant limb-girdle muscular dystrophy type 3 (implicated_via_orthology)

HNRNPDL HNRNPAB

4.04e-056492DOID:0110306 (implicated_via_orthology)
Diseasejunctional epidermolysis bullosa (is_implicated_in)

LAMA3 ITGA3

5.64e-057492DOID:3209 (is_implicated_in)
Diseasefrontotemporal dementia (implicated_via_orthology)

EWSR1 TAF15

1.76e-0412492DOID:9255 (implicated_via_orthology)
Diseaseamyotrophic lateral sclerosis (implicated_via_orthology)

EWSR1 TAF15

1.14e-0330492DOID:332 (implicated_via_orthology)
DiseaseHereditary Diffuse Gastric Cancer

PREP ITGA8 TAF15 FGG

1.42e-03293494C1708349
DiseaseStomach Neoplasms

PREP ITGA8 TAF15 FGG

1.49e-03297494C0038356
Diseaseglycine measurement

FGG PKD1L2 TUBGCP4

1.54e-03137493EFO_0009767
DiseaseMalignant neoplasm of stomach

PREP ITGA8 TAF15 FGG

1.55e-03300494C0024623

Protein segments in the cluster

PeptideGeneStartEntry
YSQPVQGYGTGAYDT

EWSR1

86

Q01844
QEMYNQYGGSYSGPD

ARID1B

1471

Q8NFD5
YNMGNSFGPYGFSYK

BCO2

236

Q9BYV7
GTGAYSPKSEYTYGA

DLX3

76

O60479
NGSAGSYPAKAYADY

DLX5

81

P56178
SYSTYGNPGSQGYGQ

TAF15

16

Q92804
YGQSQSGYSQSYGGY

TAF15

56

Q92804
AGFYEYGKASSGQTY

RBM20

226

Q5T481
QGYADYSGQQSTYGK

HNRNPDL

391

O14979
NGLYYTPVSNYGDGD

OVOS1

586

Q6IE37
YCQGGPDFYGSSVSY

DUSP13

76

Q6B8I1
PTSYLGDKVSSYGGY

LAMA3

1521

Q16787
SYGGYLTYQAKSFGL

LAMA3

1531

Q16787
YFGAPGAYNWKGNSY

ITGA3

211

P26006
SYSYSNGPGPFYNKG

PEAR1

891

Q5VY43
RSQYYMKYGNPNYGG

NCBP3

276

Q53F19
YNKYYTQAGGTLGSF

TUBGCP4

651

Q9UGJ1
LTVYSGPKGSYFGYA

ITGA8

46

P53708
GYGYHPNKSSYDAQT

PKD1L2

1211

Q7Z442
YGYGGFNISITPNYS

PREP

471

P48147
PSFDGILYYYQSGGK

KCNA10

136

Q16322
NGVYYQGGTYSKAST

FGG

371

P02679
MGSYGPAFYQSYGAS

HLA-DOA

31

P06340
YANGKLTGFYSGNSY

CCDC34

296

Q96HJ3
STGDSFYVPSGNYYN

CENPC

911

Q03188
GYGGNSATAGYSQFY

ILF3

676

Q12906
GGGSDYNYESKFNYS

ILF3

796

Q12906
YNYESKFNYSGSGGR

ILF3

801

Q12906
SFYQGYTSPYQHVPG

HOXD13

191

P35453
YDYSGYGVSSGKPSE

ABHD17C

166

Q6PCB6
SFPYEYSYGLQGGMA

ATL3

216

Q6DD88
TEFGTYAGAYYPAQG

EIF4G1

136

Q04637
GSYATYNQSGYIPSF

MAK

536

P20794
DPATYGQFYGGDSYI

GSN

461

P06396
FGAQAGQYTYGQGTY

DDX17

626

Q92841
PYKTGQYGIGFNSVY

SACS

2616

Q9NZJ4
QIYSGNSYYFGGCPD

CNTNAP5

481

Q8WYK1
SGYGIQFFGPKEYYE

MORN3

101

Q6PF18
NKYSEGYPGQRYYGG

SHMT1

71

P34896
TQFSPYGYYFVSGGH

TAF5

591

Q15542
YGYGPGYDYSQGSTN

HNRNPAB

301

Q99729
GYDYSQGSTNYGKSQ

HNRNPAB

306

Q99729
SSPYEGYNYGSFENV

SIDT2

351

Q8NBJ9
GYPGRQYYFNSSGSS

RHBDD1

226

Q8TEB9
QGSGTFPSGYYYKDQ

NXPE3

316

Q969Y0
YGSGGYALYFFPEQQ

PKDREJ

1876

Q9NTG1
ISGSNYYLYPSDGGQ

SPAG17

1031

Q6Q759
YGPGGGKYFSTTEDY

ZG16B

56

Q96DA0
EPNNKEGYYGYTGAF

TF

526

P02787
KAQGTFNSPYYPGHY

ST14

346

Q9Y5Y6
YKGAVYVYFGSKQGG

GPLD1

481

P80108
PIGCYFNIYGFGSSY

VWA5A

321

O00534
YDYGGSGGPYSKQYA

YIPF5

26

Q969M3
SGGPYSKQYAGYDYS

YIPF5

31

Q969M3
GYGAYTPSSYGANLA

USP2

26

O75604
NVYIYYPSSAGGGSQ

PPIP5K1

206

Q6PFW1
NYGSYYGVGDYPVVK

ZP4

326

Q12836