Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionantigen binding

SLC7A8 IGLV2-14 IGLV2-11 IGLV2-8

5.08e-05190224GO:0003823
DomainTeashirt_fam

TSHZ2 TSHZ1

2.94e-063192IPR027008
DomainHOMEOBOX_1

TSHZ2 TSHZ1 PITX1

1.66e-03236193PS00027
DomainHOX

TSHZ2 TSHZ1 PITX1

1.68e-03237193SM00389
DomainHomeobox_dom

TSHZ2 TSHZ1 PITX1

1.72e-03239193IPR001356
DomainHOMEOBOX_2

TSHZ2 TSHZ1 PITX1

1.72e-03239193PS50071
DomainHomeodomain-like

TSHZ2 TSHZ1 PITX1

4.37e-03332193IPR009057
DomainHomeobox

TSHZ2 PITX1

2.32e-02234192PF00046
PathwayREACTOME_CD22_MEDIATED_BCR_REGULATION

IGLV2-14 IGLV2-11 IGLV2-8

3.38e-0561153M27581
PathwayREACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL

SLC7A8 IGLV2-14 IGLV2-11 IGLV2-8

4.22e-05194154M16312
PathwayREACTOME_FCGR_ACTIVATION

IGLV2-14 IGLV2-11 IGLV2-8

4.90e-0569153M27108
PathwayREACTOME_SCAVENGING_OF_HEME_FROM_PLASMA

IGLV2-14 IGLV2-11 IGLV2-8

4.90e-0569153M27150
PathwayREACTOME_CREATION_OF_C4_AND_C2_ACTIVATORS

IGLV2-14 IGLV2-11 IGLV2-8

5.33e-0571153M1078
PathwayREACTOME_ROLE_OF_LAT2_NTAL_LAB_ON_CALCIUM_MOBILIZATION

IGLV2-14 IGLV2-11 IGLV2-8

5.33e-0571153M27203
PathwayREACTOME_INITIAL_TRIGGERING_OF_COMPLEMENT

IGLV2-14 IGLV2-11 IGLV2-8

7.62e-0580153M6121
PathwayREACTOME_ROLE_OF_PHOSPHOLIPIDS_IN_PHAGOCYTOSIS

IGLV2-14 IGLV2-11 IGLV2-8

8.21e-0582153M27110
PathwayREACTOME_ANTIGEN_ACTIVATES_B_CELL_RECEPTOR_BCR_LEADING_TO_GENERATION_OF_SECOND_MESSENGERS

IGLV2-14 IGLV2-11 IGLV2-8

9.46e-0586153M601
PathwayREACTOME_FCERI_MEDIATED_CA_2_MOBILIZATION

IGLV2-14 IGLV2-11 IGLV2-8

9.46e-0586153M27206
PathwayREACTOME_FCERI_MEDIATED_MAPK_ACTIVATION

IGLV2-14 IGLV2-11 IGLV2-8

9.79e-0587153M27205
PathwayREACTOME_FCGR3A_MEDIATED_IL10_SYNTHESIS

IGLV2-14 IGLV2-11 IGLV2-8

1.27e-0495153M29842
PathwayREACTOME_BINDING_AND_UPTAKE_OF_LIGANDS_BY_SCAVENGER_RECEPTORS

IGLV2-14 IGLV2-11 IGLV2-8

1.40e-0498153M27152
PathwayREACTOME_COMPLEMENT_CASCADE

IGLV2-14 IGLV2-11 IGLV2-8

2.24e-04115153M19752
PathwayREACTOME_PARASITE_INFECTION

IGLV2-14 IGLV2-11 IGLV2-8

2.30e-04116153M29843
PathwayREACTOME_ANTI_INFLAMMATORY_RESPONSE_FAVOURING_LEISHMANIA_PARASITE_INFECTION

IGLV2-14 IGLV2-11 IGLV2-8

3.51e-04134153M29840
PathwayREACTOME_FCERI_MEDIATED_NF_KB_ACTIVATION

IGLV2-14 IGLV2-11 IGLV2-8

3.67e-04136153M27207
PathwayREACTOME_FCGAMMA_RECEPTOR_FCGR_DEPENDENT_PHAGOCYTOSIS

IGLV2-14 IGLV2-11 IGLV2-8

4.25e-04143153M27107
PathwayREACTOME_POTENTIAL_THERAPEUTICS_FOR_SARS

IGLV2-14 IGLV2-11 IGLV2-8

5.28e-04154153M39007
PathwayREACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR

IGLV2-14 IGLV2-11 IGLV2-8

6.57e-04166153M608
PathwayREACTOME_FC_EPSILON_RECEPTOR_FCERI_SIGNALING

IGLV2-14 IGLV2-11 IGLV2-8

9.15e-04186153M27175
PathwayREACTOME_IMMUNOREGULATORY_INTERACTIONS_BETWEEN_A_LYMPHOID_AND_A_NON_LYMPHOID_CELL

IGLV2-14 IGLV2-11 IGLV2-8

9.73e-04190153M8240
PathwayREACTOME_LEISHMANIA_INFECTION

IGLV2-14 IGLV2-11 IGLV2-8

1.47e-03219153M29836
PathwayREACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS

PRND PIGG

4.28e-0393152M26985
PathwayREACTOME_HEMOSTASIS

SLC7A8 IGLV2-14 IGLV2-11 IGLV2-8

4.76e-03679154M8395
PathwayREACTOME_POST_TRANSLATIONAL_MODIFICATION_SYNTHESIS_OF_GPI_ANCHORED_PROTEINS

PRND PIGG

4.83e-0399152MM14624
Pubmed

Vertebrate orthologues of the Drosophila region-specific patterning gene teashirt.

TSHZ2 TSHZ1

4.56e-07224210704881
Pubmed

Expression and regulation of mouse Mtsh1 during limb and branchial arch development.

TSHZ2 TSHZ1

4.56e-07224211668608
Pubmed

Teashirt 3 expression in the chick embryo reveals a remarkable association with tendon development.

TSHZ2 TSHZ1

1.37e-06324216631416
Pubmed

Analysis of TSHZ2 and TSHZ3 genes in congenital pelvi-ureteric junction obstruction.

TSHZ2 TSHZ1

1.37e-06324219745106
Pubmed

Three putative murine Teashirt orthologues specify trunk structures in Drosophila in the same way as the Drosophila teashirt gene.

TSHZ2 TSHZ1

1.37e-06324214973285
Pubmed

Sequence and evolution of the human germline V lambda repertoire.

IGLV2-14 IGLV2-11 IGLV2-8

5.21e-06492438951372
Pubmed

FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4.

TSHZ2 TSHZ1

9.56e-06724219343227
Pubmed

Expression patterns of the three Teashirt-related genes define specific boundaries in the developing and postnatal mouse forebrain.

TSHZ2 TSHZ1

1.27e-05824215834955
Pubmed

One-megabase sequence analysis of the human immunoglobulin lambda gene locus.

IGLV2-14 IGLV2-11 IGLV2-8

5.78e-051092439074928
Pubmed

TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.

TSHZ2 TSHZ1

1.25e-042424224487590
Pubmed

Tbx18 Regulates the Differentiation of Periductal Smooth Muscle Stroma and the Maintenance of Epithelial Integrity in the Prostate.

DPT PITX1

1.83e-042924227120339
Pubmed

Multimodal Hox5 activity generates motor neuron diversity.

TSHZ2 TSHZ1

1.83e-042924239289460
Pubmed

The von Hippel-Lindau Cullin-RING E3 ubiquitin ligase regulates APOBEC3 cytidine deaminases.

AKAP8 DNAJC10

3.50e-044024234004371
Pubmed

Activation of C1r by proteolytic cleavage.

IGLV2-14 IGLV2-11

4.05e-04432421249422
Pubmed

Physicochemical and functional characterization of the C1r subunit of the first complement component.

IGLV2-14 IGLV2-11

4.84e-0447242814163
Pubmed

Recognition of immunoglobulins by Fcgamma receptors.

IGLV2-14 IGLV2-11

5.05e-044824211955599
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

FUBP3 PITX1 AKAP8

6.41e-0424724332989298
Cytoband22q11.2

IGLV2-14 IGLV2-11 IGLV2-8

3.39e-0512024322q11.2
CytobandEnsembl 112 genes in cytogenetic band chr14q11

SLC7A8 TRAV8-1 TRAV1-1

6.78e-04332243chr14q11
CytobandEnsembl 112 genes in cytogenetic band chr22q11

IGLV2-14 IGLV2-11 IGLV2-8

1.32e-03419243chr22q11
Cytoband14q11

TRAV8-1 TRAV1-1

2.17e-0313224214q11
GeneFamilyImmunoglobulin lambda locus at 22q11.2

IGLV2-14 IGLV2-11 IGLV2-8

6.16e-0589163353
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

TSHZ2 TSHZ1

7.66e-0515162529
GeneFamilyT-cell receptor alpha locus at 14q11.2

TRAV8-1 TRAV1-1

4.70e-03117162371
CoexpressionAtlasratio_EmbryoidBody_vs_StemCell_top-relative-expression-ranked_500_k-means-cluster#1

TSHZ2 PTGS2 PITX1

1.59e-0550213ratio_EB_vs_SC_500_K1
ToppCell10x5'-Lung-Lymphocytic_B_plasma|Lung / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8 PITX1

3.09e-081722458156fb6de66a4c92ade703b71c2e9187291e50ef
ToppCell10x5'-Lung-Lymphocytic_B_plasma-Plasmablasts|Lung / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8 GGCX

3.77e-081792453fa75eec3e86fd1797eaa33362257df7f9b2a0bf
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.40e-061562445d9e1df70f2e9219f6b029be2e39297605d36726
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.47e-0615824417a13c5719eb363f2eb8f1d4e171429c6a1ce1e9
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.47e-06158244e5451cfe67e882eb0c1eca287740f8ab75370abc
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.47e-061582441397078f909338fa5fa3b01748db891e5e3fc9e7
ToppCellnormal_Lung-B_lymphocytes-MALT_B_cells|normal_Lung / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.51e-06159244fbd0131b66f4267f7b0d6c3ad874ad097b859074
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.51e-061592441827493fb464bbddb2ee23f99472cfbcaf57405b
ToppCellBAL-Mild-Lymphocyte-B-Plasmablast-Plasmablast|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.51e-061592446ecc3cb2daa5887b59836842be414a00cdcdaeec
ToppCellMild-Lymphoid-Plasma-|Mild / Condition, Lineage, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.55e-06160244aa79848913910c01249d6cacf4ed53ec0e4f5c3d
ToppCellMild-Lymphoid-Plasma|Mild / Condition, Lineage, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.55e-061602447fdb849f5caf5a127a2582326215e11f8eb4fa0e
ToppCellMild_COVID-19-B_cell-Plasmablast|Mild_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.63e-06162244b67f6fb3d7f6093c8ef02398ff8fea4d0fb41a3b
ToppCell10x5'-Lung-Lymphocytic_B_plasma-Plasma_cells|Lung / Manually curated celltypes from each tissue

IGLV2-14 IGLV2-11 IGLV2-8 PITX1

1.88e-06168244e8bd090de5c9fe286b08a8b314ce12cf988184f0
ToppCellBAL-Mild-Lymphocyte-B|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.93e-06169244307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCelltumor_Lung-B_lymphocytes-Plasma_cells|tumor_Lung / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

1.93e-06169244b36b7632ce55fc7b6b8b66020563d360b3de6fd7
ToppCell10x5'-Lung-Lymphocytic_B-Memory_B_cells|Lung / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.06e-061722442cb2dc7cfd6db5a98a393b1a84c23abf3d692a53
ToppCell3'_v3-bone_marrow-Lymphocytic_B_plasma-Plasma_cells|bone_marrow / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.21e-0617524451301f3f44d3e88397f367cedd1e2abaa2be4c6f
ToppCellControl-Lymphoid_P|Control / Disease group, lineage and cell class

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.26e-06176244d895a6b295cd649273ff80ad7785a3e0ae4c728a
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.26e-0617624467d6dc38708692f8c58cea5ed896f10718e9ffa6
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.26e-06176244125be81311f87563ca321472fcce6e0e0ae24c16
ToppCellControl-Lymphoid_P-Plasmablast|Control / Disease group, lineage and cell class

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.26e-061762444b4416f342b732d2cc60133838728880326257d8
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.31e-06177244c2b0fb5921eea24d248d6e6ccb57c29b0832602c
ToppCell-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

TSHZ2 PKHD1L1 IGLV2-14 IGLV2-11

2.31e-06177244ae2d2e138946535596fa30a55207f261cafda461
ToppCell(2)_Plasma_cells|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.31e-06177244ed3c936bb69f9bc7291b4f6cde1d204078117c48
ToppCellkidney_cells-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-Plasma_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.31e-06177244111fb0707ff37ca631d85bb5a09e067ffe568eb8
ToppCelltumor_Lung-B_lymphocytes-MALT_B_cells|tumor_Lung / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.31e-0617724437e03f51925345f5f716ef3abe1d2c4ccf129020
ToppCell356C-Lymphocytic-Plasma_cell|356C / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.53e-06181244f1d88b83a13acd1c8e6b9ff8bd0acaff3650ceef
ToppCell356C-Lymphocytic-Plasma_cell-|356C / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.53e-0618124470cd612706640d8ebf0e047582b1daa2c1121526
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.53e-06181244f7b08f662eb77ee7a777c6525ddc3195046aaf65
ToppCell10x5'-Lung-Lymphocytic_B|Lung / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.58e-06182244310f94437d197eaaaf6e30e68063b33e94befe77
ToppCellControl-Lymphocyte-B-B_memory|Control / Disease, Lineage and Cell Type

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.64e-06183244491fa04a1d2caeeec6c6403c9a38b4a1257fc2bc
ToppCell367C-Lymphocytic-Plasma_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.70e-06184244fc708a5c8a7b19fab973c72dc4383a7d30f8b59a
ToppCell367C-Lymphocytic-Plasma_cell-|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.70e-0618424414a5288d861260f63fbe0cbea3569cf643e7597e
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.76e-0618524496423bdcf0e85ca41370f79347d27c22f3de98f5
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.76e-061852440fff2608f507e019ebb69c27e58fd5be3b049bef
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Lymphocytic_B-Plasma_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.76e-0618524479edc1eeb7b5b9123961ac3ecf398ee68d9dddb9
ToppCellcellseq2-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

2.94e-0618824433360f1c30315d9772731c9067834dc059172b79
ToppCellnormal_Lymph_Node-B_lymphocytes-MALT_B_cells|normal_Lymph_Node / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

3.06e-061902441f907016980ccfbf089e354d91d931771e8a83e0
ToppCellcellseq2-Immune-Lymphocytic_B-Lymphocytic_B|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

3.13e-0619124417746a32f723c078aba1f7e320b0e3f1ab8bf5c6
ToppCellcellseq2-Immune-Lymphocytic_B|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

3.13e-06191244c2c450df810f83163987cd0f7ed9b50025cd3de1
ToppCellBronchial-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasma_IgA|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

3.40e-0619524413f4ee21568fd747608412d33559d10561dbb3c8
ToppCellBiopsy_IPF-Immune-Plasma_cells|Biopsy_IPF / Sample group, Lineage and Cell type

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

3.47e-06196244a1b6a8000b86efcb07843998aa3a49bb1f54bcda
ToppCellBAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TSHZ2 TRAV8-1 IGLV2-14 TRAV1-1

3.54e-061972449acf6719126ca335f584811a72b46af485d67437
ToppCellBAL-Control-Lymphocyte-T/NK-CD4+_T-CD4+_T|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TSHZ2 TRAV8-1 IGLV2-14 TRAV1-1

3.54e-0619724482eab092d075507889fe1d8845c754a7f0bed30a
ToppCellControl-Control-Lymphocyte-B-Plasmablast|Control / Disease, condition lineage and cell class

PKHD1L1 IGLV2-14 IGLV2-11 IGLV2-8

3.68e-06199244c11aa8bca3723a886e7082ae48bb922dd8396be4
ToppCelltumor_Lymph_Node_/_Brain-B_lymphocytes-Plasma_cells|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-8

1.73e-05942434b6623de5a517ebf5df865e0dcd615111622ad3e
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma-8|TCGA-Bladder / Sample_Type by Project: Shred V9

ATP8B1 PIGG AKAP8

6.85e-0514924389705865e94360c1288ee98c5a6b381f3c6242b3
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgG_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGLV2-11 IGLV2-8 PITX1

7.26e-05152243a2ba2d95ac9010e1a62db34dcad10d004f8a90cc
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

SLC7A8 GGCX PITX1

7.70e-05155243d7e26696fd9c0a759524f331243db43059b33ed9
ToppCell343B-Lymphocytic-Plasma_cell-|343B / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 IGLV2-14 IGLV2-8

7.99e-05157243554ddbaf83f5d6eb4669c673efdbb28fd87e2ba8
ToppCell343B-Lymphocytic-Plasma_cell|343B / Donor, Lineage, Cell class and subclass (all cells)

PKHD1L1 IGLV2-14 IGLV2-8

7.99e-051572432cb3deb5313ce734710c601935ca318e4179077e
ToppCellIIF-Lymphocyte-B-Plasmablast|IIF / Disease, Lineage and Cell Type

PKHD1L1 IGLV2-11 IGLV2-8

8.61e-051612434d78985e7b11e92591e75a4864fd769882db2d1c
ToppCell-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

PKHD1L1 DPT IGLV2-14

9.10e-051642432d65f025f921a5327bfd8d260815baaed00ef3fa
ToppCell3'-GW_trimst-1-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSHZ2 DPT AKAP8

9.10e-05164243d167c7a987b9b35d1e7725c803df4f9cd5380e47
ToppCellhealthy_donor-Lymphocytic-Plasma_cell-IgM_Plasmablast|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGLV2-14 IGLV2-11 IGLV2-8

9.43e-051662432b7b580bec8d9467b0deaf97098065f72dbf2a4f
ToppCell367C-Lymphocytic-Plasma_cell-|367C / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8

9.60e-05167243f2185eb72f0137136f6d71af2a70168fded6c940
ToppCell367C-Lymphocytic-Plasma_cell|367C / Donor, Lineage, Cell class and subclass (all cells)

IGLV2-14 IGLV2-11 IGLV2-8

9.60e-051672435e768cf24699893e05d1bcb1c92dba2336943a64
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-myeloid-myeloid_dendritic-plasmacytoid_dendritic_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

IGLV2-14 IGLV2-11 IGLV2-8

9.60e-05167243afb6d0993f3fd44a295874673055189d514f7b11
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-Plasma_cells-IgG_plasma_cell|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV2-14 IGLV2-11 IGLV2-8

9.94e-051692430c2384f780ec25710ebb35c0b0df8f4afb53c9b1
ToppCellE17.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TSHZ2 DPT ATP8B1

1.01e-041702437fa022471e14ac8a3bc147c793368a4d56a8e591
ToppCellmetastatic_Brain-B_lymphocytes-Plasma_cells|metastatic_Brain / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11

1.01e-0417024353634da9e9c72f6400639954c286c6e38ea5a188
ToppCellCOVID-19_Convalescent|World / Disease condition and Cell class

TSHZ2 IGLV2-14 IGLV2-8

1.03e-041712430784fcc45d7b5afba004dd65247d17f452f52b30
ToppCellmetastatic_Brain-B_lymphocytes-MALT_B_cells|metastatic_Brain / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-8

1.12e-0417624350e207403d48ce1b55a78897adb5519a2430a626
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

IGLV2-14 IGLV2-11 IGLV2-8

1.14e-041772434c434a7b7cc54cf4dac996bbc3f5124d9ef9a9cd
ToppCell10x5'-Liver-Lymphocytic_B_plasma-Plasmablasts|Liver / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11

1.14e-041772431d88ae316d65ca5fdc736c9da93885b6b40c32bb
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGLV2-14 IGLV2-11 IGLV2-8

1.14e-04177243fc40918825b7e1eb6861df59dfca944778a64b98
ToppCellHealthy-Plasmablast|Healthy / disease group, cell group and cell class

IGLV2-14 IGLV2-11 IGLV2-8

1.14e-041772434ff75c609ac9edf7a94bda42eb7124c559e8b6aa
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

IGLV2-14 IGLV2-11 IGLV2-8

1.14e-04177243d746122bf8d208c3aa4d156e8c12d0a0e555c6e5
ToppCellHealthy_donor-Plasmablast|Healthy_donor / disease group, cell group and cell class (v2)

IGLV2-14 IGLV2-11 PITX1

1.16e-04178243388b8b4fa20dcc6e9ae4b06118e20b2c20c52bde
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-14 IGLV2-11 IGLV2-8

1.18e-04179243837ed81f18257f444eaeadc4fac89deedd4e3061
ToppCell3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TSHZ2 PKHD1L1 PTGS2

1.18e-04179243ec1d7017da325647b629de703135a404bbdc627d
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-14 IGLV2-11 IGLV2-8

1.18e-04179243494febe77c6d4e6a2c6f0928bbf4c84b0301f188
ToppCellPBMC-Control-Lymphocyte-B-Plasmablast-Plasmablast|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

IGLV2-14 IGLV2-11 IGLV2-8

1.18e-04179243b6ee4f41d8fb5f047b7bdd8489dda0a89fc6d43f
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-14 IGLV2-11 IGLV2-8

1.20e-04180243cea079bc02e08c46600eed05ab9924ec90e1e3d3
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells-Plasma_cells_L.1.7.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PKHD1L1 IGLV2-14 IGLV2-8

1.24e-041822431bf2e4fd6222b41a7d08df6dcc500c9401db8c18
ToppCellcellseq-Immune-Lymphocytic_B-Lymphocytic_B-Plasma|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

IGLV2-14 IGLV2-11 IGLV2-8

1.26e-041832435ab4aa0304b832f98fff89b6c24ad5b7dd014c11
ToppCell10x5'-Liver-Lymphocytic_B_plasma-Plasma_cells|Liver / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-8

1.28e-041842436f70d8f8ab8362d51f8a58735d42223e06566397
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-14 IGLV2-11 IGLV2-8

1.28e-0418424315f2c10101ccc8ed059520fc082ee42593dff269
ToppCell3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-14 IGLV2-11 IGLV2-8

1.28e-04184243a90a58d9e319afa1cd572e4c2f516fadc42f56e5
ToppCellILEUM-non-inflamed-(5)_IgM_plasma_cells|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PKHD1L1 IGLV2-14 IGLV2-8

1.28e-04184243e34eab6e1b0354953c570d70b458e3065db75cbf
ToppCellmetastatic_Lymph_Node-B_lymphocytes-MALT_B_cells|metastatic_Lymph_Node / Location, Cell class and cell subclass

PKHD1L1 IGLV2-14 IGLV2-11

1.30e-04185243bb87fa174f80706fe7be60d3b9fc3e2a6b373038
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-14 IGLV2-11 IGLV2-8

1.30e-0418524308bc817908076734d66f2805cb954141f2cc5a18
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell-Plasma_cells|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PKHD1L1 IGLV2-14 IGLV2-8

1.30e-041852436ec009e48e50471c28e914c402f500e56a88f8f2
ToppCell3'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PKHD1L1 IGLV2-14 IGLV2-8

1.30e-04185243f49ad6401b2abd089e30eba245b11b5031ea2318
ToppCell5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-plasma_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

IGLV2-14 IGLV2-11 IGLV2-8

1.30e-041852431704a12153a9b107bf03ecccd1a036cf61334d7a
ToppCell10x5'-Liver-Lymphocytic_B_plasma|Liver / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11

1.32e-04186243a2c7430781f432c9c90ac4d620f4518ff767a223
ToppCellhealthy_donor-Lymphocytic-Plasma_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

IGLV2-14 IGLV2-11 IGLV2-8

1.36e-04188243bd53b0371154cff680226897b61c9809a239d1b6
ToppCellSevere_COVID-19-B_cell|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PKHD1L1 IGLV2-14 IGLV2-11

1.38e-0418924359ce8f15f413557d2059ee6b53ba5957b864cb8e
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PKHD1L1 IGLV2-14 IGLV2-11

1.38e-04189243b0fcbe13a91a4b8dfa507b7a484f45477ef31609
ToppCellSevere_COVID-19-B_cell-Plasmablast|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）

PKHD1L1 IGLV2-14 IGLV2-11

1.38e-04189243d7bfefc8c35374c5288807349a76dbb10e84c52b
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 IGLV2-14 IGLV2-11

1.38e-04189243d5d25f4151ea96e2d4b3a0e0910e7ff995eaf752
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic-plasma_cell|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PKHD1L1 IGLV2-14 IGLV2-11

1.38e-041892435a42be62552d912d0abf68f00d75ac80bbd69f2c
ToppCell3'_v3-bone_marrow-Lymphocytic_B_plasma|bone_marrow / Manually curated celltypes from each tissue

PKHD1L1 IGLV2-14 IGLV2-11

1.38e-04189243dceb011216deb4ffd830144a53c635c05dff5ec5
ToppCellBAL-Severe-Lymphocyte-B-Plasmablast-Plasmablast|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

PKHD1L1 IGLV2-14 IGLV2-11

1.38e-041892430f0607642eecc66222d23afe6d77b6872343cb8e
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-lymphocytic-B_lymphocytic|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PKHD1L1 IGLV2-14 IGLV2-11

1.41e-04190243a21d0c574abf21e7cb865a21a48f29c92d055fbe
ToppCellBAL-Severe-Lymphocyte-B|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PKHD1L1 IGLV2-14 IGLV2-11

1.41e-04190243e82fefea5ac03470d10463832d3efd2380895860
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT PTGS2 GGCX

1.41e-04190243990ac07f4b0a22041daac7502f74fafd6d258cba
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Plasma_cells|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IGLV2-14 IGLV2-11 IGLV2-8

1.41e-0419024379ee6d10dfbb775da149a1104da5823cf63bbb46
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal-fibroblast|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT PTGS2 GGCX

1.41e-04190243fc9bbe5e6e0ec3cfa47bf479d8b09a0fc53169cc
ToppCellfacs-Thymus-Flowthrough-24m-Mesenchymal|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DPT PTGS2 GGCX

1.41e-0419024339ecdf8815e235771132684dfc1aff1917e20965
Drug4-phenylchalcone Oxide

DPT PTGS2

1.70e-057212CID000150734
Drugalpha-estradiol; Up 200; 0.01uM; HL60; HT_HG-U133A

SLC7A8 TSHZ2 DPT RPGRIP1L

2.84e-051962142670_UP
DrugN-(3-oxododecanoyl)-L-homoserine lactone

GLB1 PTGS2

7.32e-0514212CID000127864
DrugnaBE

SLC7A8 PTGS2

1.09e-0417212CID000151475
Drugdhpta

GLB1 DPT PTGS2

1.16e-04104213CID000018465
Drug2,3-dibromopropyl-2,4,6-tribromophenyl ether

SLC7A8 PTGS2

1.85e-0422212ctd:C547124
Drugphenylalaninol

SLC7A8 TSHZ1

2.60e-0426212CID000076652
Drug14,15-DHET

GLB1 PTGS2

2.60e-0426212CID005283147
Drugesculin

GLB1 PITX1

3.95e-0432212CID005281417
DrugDB07831

GGCX PITX1

5.01e-0436212CID010477723
Drugcystamine

PRND DPT FOXRED1

5.91e-04181213CID000002915
DrugAC1L3U0V

GLB1 PRND

6.19e-0440212CID000122124
Drug18alpha-glycyrrhetinic acid

PTGS2 ATP8B1

6.19e-0440212ctd:C119129
Drug11,12,15-trihydroxyeicosatrienoic acid

GLB1 PTGS2

6.82e-0442212CID006439610
DrugTrimethoprim [738-70-5]; Down 200; 13.8uM; PC3; HT_HG-U133A

PTGS2 ATP8B1 PITX1

7.45e-041962137377_DN
DrugGleevec; Up 200; 10uM; PC3; HG-U133A

PRND FUBP3 ATP8B1

7.45e-04196213483_UP
Drugnordihydroguaiaretic acid; Down 200; 1uM; MCF7; HG-U133A

SLC7A8 ATP8B1 PITX1

7.45e-04196213203_DN
DrugNalidixic acid sodium salt hydrate; Up 200; 14.6uM; PC3; HT_HG-U133A

SLC7A8 DPT PITX1

7.45e-041962133668_UP
Drug2-methylbutylamine

SLC7A8 PRND

7.49e-0444212CID000007283
DrugMesoridazine besylate [32672-69-8]; Down 200; 7.4uM; HL60; HG-U133A

FUBP3 ATP8B1 DNAJC10

7.56e-041972131725_DN
DrugNiridazole [61-57-4]; Down 200; 18.6uM; MCF7; HT_HG-U133A

TRNAU1AP ATP8B1 AKAP8

7.56e-041972133301_DN
DrugSulmazole [73384-60-8]; Down 200; 14uM; PC3; HT_HG-U133A

PTGS2 RPGRIP1L PITX1

7.56e-041972134009_DN
DrugKynurenine, 3-hydroxy (R,S) [2147-61-7]; Up 200; 17.8uM; MCF7; HT_HG-U133A

SLC7A8 PRND RPGRIP1L

7.56e-041972135641_UP
DrugSotalol hydrochloride [959-24-0]; Down 200; 13uM; PC3; HT_HG-U133A

SLC7A8 PTGS2 PITX1

7.56e-041972134079_DN
DrugArecoline hydrobromide [300-08-3]; Down 200; 17uM; MCF7; HT_HG-U133A

SLC7A8 PITX1 AKAP8

7.68e-041982132657_DN
Drug2-propylpentanoic acid; Up 200; 50uM; PC3; HT_HG-U133A

SLC7A8 ATP8B1 PITX1

7.68e-041982131222_UP
DrugNilutamide [63612-50-0]; Up 200; 12.6uM; MCF7; HT_HG-U133A

SLC7A8 DPT PITX1

7.68e-041982136481_UP
DrugIsoniazid [54-85-3]; Down 200; 29.2uM; HL60; HG-U133A

GGCX ATP8B1 DNAJC10

7.79e-041992131399_DN
DrugAmino Acids, Peptides, and Proteins

SLC7A8 PTGS2

7.83e-0445212ctd:D000602
DrugXylenes

DPT PTGS2

7.83e-0445212ctd:D014992
DrugLoxapine succinate [27833-64-3]; Up 200; 9uM; HL60; HG-U133A

FUBP3 PTGS2 ATP8B1

7.90e-042002132016_UP
DrugNSC-364372

GLB1 PRND PTGS2 FOXRED1

9.06e-04484214CID000435143
Diseasebasophil measurement

SLC7A8 GGCX

7.55e-0460202EFO_0803539
DiseaseBenign Neoplasm

PTGS2 DNAJC10

9.68e-0468202C0086692
DiseaseNeoplasms

PTGS2 DNAJC10

9.68e-0468202C0027651
Diseasebipolar disorder, body mass index

TSHZ2 RPGRIP1L

1.08e-0372202EFO_0004340, MONDO_0004985
DiseaseKidney Diseases

PTGS2 RPGRIP1L

1.61e-0388202C0022658

Protein segments in the cluster

PeptideGeneStartEntry
AYGTGVASWQGYENY

AKAP8

21

O43823
VASWQGYENYNYYGA

AKAP8

26

O43823
PYQQYHDYSDDGWVN

DPT

26

Q07507
FWYSFFNGYSAQTAY

ATP8B1

966

O43520
GSFAYGGWNFLNYVT

SLC7A8

241

Q9UHI5
GQWVYYNYSNVIYVD

RPGRIP1L

1196

Q68CZ1
GTNFAYWNGANSPYA

GLB1

311

P16278
AWAEYYRQQVAFYGQ

FUBP3

546

Q96I24
YNADYGYKSWEAFSN

PTGS2

116

P35354
AGNNVQYIWSYYSVA

KCTD18

191

Q6PI47
AWAGYYDYNTFDQNG

FOXRED1

406

Q96CU9
DNQGGQYESWNYYRY

DNAJC10

106

Q8IXB1
SDVGGYNYVSWYQQH

IGLV2-11

46

P01706
SDVGGYNYVSWYQQH

IGLV2-14

46

P01704
YEDVYAAGYSYNNWA

PITX1

171

P78337
QNYYAQWGYDQNTGS

TRNAU1AP

201

Q9NX07
QWGYDQNTGSYSYSY

TRNAU1AP

206

Q9NX07
SDVGGYNYVSWYQQH

IGLV2-8

46

P01709
GYNNWTNGLYGYSWD

GGCX

386

P38435
GAEGNRYYEANYWQF

PRND

71

Q9UKY0
TQFTYNFAYGNNWTY

PKHD1L1

776

Q86WI1
SNNRYGYQNGASYTW

TSHZ2

356

Q9NRE2
GCNYSYGGTVNLFWY

TRAV8-1

41

A0A0A6YYK1
YQTSGFYGLSWYQQH

TRAV1-1

41

A0A0B4J248
HYWFGQAFFYFQGNS

PIGG

846

Q5H8A4
YGYQNGASYTWQFEA

TSHZ1

396

Q6ZSZ6