Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessstriatum development

BBS1 BBS4 OGDH

1.77e-0522483GO:0021756
GeneOntologyBiologicalProcessubiquitin-dependent protein catabolic process via the N-end rule pathway

UBR2 UBR4

3.17e-054482GO:0071596
GeneOntologyBiologicalProcesssubpallium development

BBS1 BBS4 OGDH

3.72e-0528483GO:0021544
GeneOntologyCellularComponentBBSome

BBS1 BBS4

1.43e-048482GO:0034464
DomainLaminin_EGF

CRELD1 NTN1 MEGF10

9.24e-0535473PF00053
DomainLaminin_EGF

CRELD1 NTN1 MEGF10

1.18e-0438473IPR002049
Domainzf-UBR

UBR2 UBR4

1.29e-047472PF02207
DomainZnf_UBR

UBR2 UBR4

1.29e-047472IPR003126
DomainZnF_UBR1

UBR2 UBR4

1.29e-047472SM00396
DomainZF_UBR

UBR2 UBR4

1.29e-047472PS51157
Domain-

INPP5B ANGEL1

1.94e-03264723.60.10.10
DomainExo_endo_phos

INPP5B ANGEL1

1.94e-0326472PF03372
DomainEndo/exonuclease/phosphatase

INPP5B ANGEL1

2.09e-0327472IPR005135
DomainEGF_Lam

NTN1 MEGF10

3.50e-0335472SM00180
DomainEGF_1

HYAL4 CRELD1 NTN1 MEGF10

3.82e-03255474PS00022
DomainEGF_2

HYAL4 CRELD1 NTN1 MEGF10

4.38e-03265474PS01186
DomainGlycoside_hydrolase_SF

HYAL4 AGL

7.87e-0353472IPR017853
DomainQuinoprotein_ADH-like_supfam

BBS1 CFAP57

7.87e-0353472IPR011047
Pubmed

Loss of BBS proteins causes anosmia in humans and defects in olfactory cilia structure and function in the mouse.

BBS1 BBS4

1.94e-06249215322545
Pubmed

Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function.

BBS1 BBS4

1.94e-06249217959775
Pubmed

The BBSome assembly is spatially controlled by BBS1 and BBS4 in human cells.

BBS1 BBS4

1.94e-06249232759308
Pubmed

Loss of Bardet-Biedl syndrome proteins causes synaptic aberrations in principal neurons.

BBS1 BBS4

5.83e-06349231479441
Pubmed

Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators.

BBS1 BBS4

5.83e-06349224691443
Pubmed

Basal body proteins regulate Notch signaling through endosomal trafficking.

BBS1 BBS4

5.83e-06349224681783
Pubmed

Direct evidence for BBSome-associated intraflagellar transport reveals distinct properties of native mammalian cilia.

BBS1 BBS4

5.83e-06349225504142
Pubmed

A knockin mouse model of the Bardet-Biedl syndrome 1 M390R mutation has cilia defects, ventriculomegaly, retinopathy, and obesity.

BBS1 BBS4

1.16e-05449218032602
Pubmed

Reversal of ciliary mechanisms of disassembly rescues olfactory dysfunction in ciliopathies.

BBS1 BBS4

1.16e-05449235771640
Pubmed

Loss of Bardet-Biedl syndrome proteins alters the morphology and function of motile cilia in airway epithelia.

BBS1 BBS4

1.16e-05449218299575
Pubmed

A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons.

UBR2 UBR4

1.16e-05449216055722
Pubmed

Evaluation of complex inheritance involving the most common Bardet-Biedl syndrome locus (BBS1).

BBS1 BBS4

1.16e-05449212524598
Pubmed

The substrate recognition domains of the N-end rule pathway.

UBR2 UBR4

1.16e-05449219008229
Pubmed

BBS4 is required for intraflagellar transport coordination and basal body number in mammalian olfactory cilia.

BBS1 BBS4

1.16e-05449230665891
Pubmed

Regulation of Insulin Receptor Trafficking by Bardet Biedl Syndrome Proteins.

BBS1 BBS4

1.16e-05449226103456
Pubmed

The absence of BBSome function decreases synaptogenesis and causes ectopic synapse formation in the retina.

BBS1 BBS4

1.94e-05549232433491
Pubmed

Requirement of Bardet-Biedl syndrome proteins for leptin receptor signaling.

BBS1 BBS4

1.94e-05549219150989
Pubmed

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.

BBS1 BBS4

1.94e-05549216170314
Pubmed

BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes.

BBS1 BBS4

2.91e-05649222228099
Pubmed

Bardet-Biedl syndrome proteins 1 and 3 regulate the ciliary trafficking of polycystic kidney disease 1 protein.

BBS1 BBS4

2.91e-05649224939912
Pubmed

BBS mutations modify phenotypic expression of CEP290-related ciliopathies.

BBS1 BBS4

4.07e-05749223943788
Pubmed

Protein interaction perturbation profiling at amino-acid resolution.

BBS1 BBS4

4.07e-05749229039417
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

PLEKHG1 AGAP5 MDN1 GLG1 ANKS1B XPNPEP1 OGDH ELMO1 IFNAR1

5.20e-05124249930973865
Pubmed

Dissection of epistasis in oligogenic Bardet-Biedl syndrome.

BBS1 BBS4

5.42e-05849216327777
Pubmed

Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.

PLEKHG1 MEGF10 ELMO1

5.86e-055349323535033
Pubmed

Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation.

BBS1 BBS4

6.96e-05949222302990
Pubmed

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.

BBS1 BBS4

6.96e-05949218762586
Pubmed

The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia.

BBS1 BBS4

6.96e-05949220603001
Pubmed

Human immunodeficiency virus type 1 Vpr links proteasomal degradation and checkpoint activation.

UBR2 UBR4

6.96e-05949217855541
Pubmed

Ubiquitylation of BBSome is required for ciliary assembly and signaling.

BBS1 BBS4

6.96e-05949236744302
Pubmed

E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.

URB1 MDN1 AGL UBR4 NCBP1 CFAP57 MEGF10

7.33e-0573649729676528
Pubmed

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.

BBS1 BBS4

8.69e-051049222072986
Pubmed

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

BBS1 BBS4

8.69e-051049217574030
Pubmed

DAZ-interacting Protein 1 (Dzip1) Phosphorylation by Polo-like Kinase 1 (Plk1) Regulates the Centriolar Satellite Localization of the BBSome Protein during the Cell Cycle.

BBS1 BBS4

8.69e-051049227979967
Pubmed

Temporal expression pattern of Bardet-Biedl syndrome genes in adipogenesis.

BBS1 BBS4

8.69e-051049217379567
Pubmed

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes.

BBS1 BBS4

8.69e-051049222139371
Pubmed

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts.

NCBP1 ZFC3H1

8.69e-051049227871484
Pubmed

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

BBS1 BBS4

8.69e-051049219081074
Pubmed

The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.

BBS1 BBS4

1.06e-041149224550735
Pubmed

The cardiac-restricted protein ADP-ribosylhydrolase-like 1 is essential for heart chamber outgrowth and acts on muscle actin filament assembly.

ADPRHL1 POPDC2

1.06e-041149227217161
Pubmed

Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.

BBS1 BBS4

1.06e-041149225552655
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

NRDE2 URB1 GLG1 INPP5B ANGEL1 ZNF267 BBS4 BTLA

1.26e-04108449811544199
Pubmed

HIV-1 Vpr function is mediated by interaction with the damage-specific DNA-binding protein DDB1.

UBR2 UBR4

1.27e-041249217360488
Pubmed

TNF-α sculpts a maturation process in vivo by pruning tolerogenic dendritic cells.

BTLA IFNAR1

1.50e-041349235417681
Pubmed

Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome.

BBS1 BBS4

1.50e-041349222500027
Pubmed

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

BBS1 BBS4

2.02e-041549220080638
Pubmed

The BBSome controls IFT assembly and turnaround in cilia.

BBS1 BBS4

2.02e-041549222922713
Pubmed

Network-driven discovery yields new insight into Shox2-dependent cardiac rhythm control.

NTN1 MEGF10

2.61e-041749233706013
Pubmed

FIP200 controls the TBK1 activation threshold at SQSTM1/p62-positive condensates.

MDN1 CCDC47 BBS4 NCBP1

2.78e-0422349434226595
Pubmed

¹H NMR metabolic profiling of plasma reveals additional phenotypes in knockout mouse models.

AGL PRIMPOL

3.64e-042049225849460
Pubmed

Novel interaction partners of Bardet-Biedl syndrome proteins.

BBS1 BBS4

4.01e-042149218000879
Pubmed

Global landscape of HIV-human protein complexes.

UBR2 CHAF1B CCDC47 GLG1 UBR4

4.54e-0445749522190034
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

URB1 MDN1 NCBP1 ZFC3H1 OGDH MED12

6.66e-0475949635915203
Pubmed

Bardet-Biedl Syndrome Overview

BBS1 BBS4

6.67e-042749220301537
Pubmed

Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.

UBR2 MDN1 INPP5B UBR4 OGDH

7.78e-0451549531617661
Pubmed

Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.

BBS1 BBS4

8.25e-043049219077438
Pubmed

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

CHAF1B URB1 MDN1 CCDC47 UBR4 NCBP1 DDX60L OGDH

8.41e-04144049830833792
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

MDN1 CCDC47 UBR4 ANKS1B NCBP1 ZFC3H1 NEB OGDH

8.49e-04144249835575683
Pubmed

Loss of ER retention motif of AGR2 can impact mTORC signaling and promote cancer metastasis.

MDN1 GLG1 UBR4 NCBP1 XPNPEP1 OGDH

9.16e-0480749630575818
Pubmed

KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.

UBR2 UBR4

9.98e-043349225582440
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

PLEKHG1 URB1 MDN1 CCDC47 GLG1 UBR4 ZFC3H1 OGDH

1.04e-03148749833957083
Pubmed

Systematic identification of factors for provirus silencing in embryonic stem cells.

CHAF1B MDN1 UBR4

1.33e-0315349326365490
Cytoband3q13.2

USF3 BTLA

5.09e-04314923q13.2
CytobandEnsembl 112 genes in cytogenetic band chr3q13

USF3 BTLA POPDC2

1.72e-03221493chr3q13
Cytoband21q22.11

URB1 IFNAR1

2.03e-036249221q22.11
GeneFamilyUbiquitin protein ligase E3 component n-recognins

UBR2 UBR4

3.84e-057252785
GeneFamilyBardet-Biedl syndrome associated|BBSome

BBS1 BBS4

5.11e-0582521122
GeneFamilyBardet-Biedl syndrome associated|BBSome

BBS1 BBS4

3.79e-0421252980
GeneFamilyAnkyrin repeat domain containing

AGAP5 ANKS1B KANK4

4.38e-03242253403
CoexpressionGSE411_UNSTIM_VS_100MIN_IL6_STIM_SOCS3_KO_MACROPHAGE_UP

MDN1 CCDC47 AGL NEB MED12

3.57e-05200495M6004
CoexpressionGSE557_WT_VS_I_AB_KO_DC_UP

CRELD1 NRDE2 ANGEL1 NEB IFNAR1

3.57e-05200495M6009
CoexpressionGOLDRATH_NAIVE_VS_EFF_CD8_TCELL_UP

MDN1 DTX1 INPP5B UBR4 MED12

3.57e-05200495M3035
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-1|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 USF3 DTX1 BTLA

1.44e-06176495ad05dd934f4ac2e656b3455de091f4c8772de6c8
ToppCellHealthy-B_intermediate|Healthy / disease group, cell group and cell class

TLR10 PLEKHG1 DTX1 BTLA NEB

2.31e-06194495aabee48bf689367edae2079b4b90d253715f1097
ToppCelldroplet-Fat-Mat-18m-Mesenchymal-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARMCX6 NTN1 MED12 PRIMPOL

9.60e-06121494e82c9e10b98c8d7ad828cf8ac19a2342014be2ba
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 DTX1 NEB

2.61e-05156494d81e78bec5c8a3f3ec9e1447ebab2c5805b815eb
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-naive_B_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TLR10 PLEKHG1 DTX1 BTLA

2.88e-05160494bfbac5ed3273b4430314c6c25cdc1bf0c42b27a1
ToppCellAdult-Epithelial-lung_goblet_cell-D175|Adult / Lineage, Cell type, age group and donor

URB1 NHS NTN1 MUC5AC

3.17e-051644946e6aedb61f8e195d52e028fdda750a29bb14e57e
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_naive-B_naive-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 USF3 BTLA

3.25e-05165494fead3f2032f8fa5f7f0159a4434989b3d65debbb
ToppCell3'_v3-bone_marrow-Lymphocytic_B-ABC_aged-B_naive|bone_marrow / Manually curated celltypes from each tissue

TLR10 PLEKHG1 DTX1 TRMT5

3.73e-05171494fcc31a9a69f96de10d1324a5a4fbfe4289bf4984
ToppCellControl-B_cells-B_cells|Control / group, cell type (main and fine annotations)

TLR10 PLEKHG1 DTX1 BTLA

4.18e-05176494d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

URB1 NHS NTN1 MUC5AC

4.27e-05177494779ba86f53650772755b52460be03f18bb204e55
ToppCellnucseq-Epithelial-Epithelial_Airway-Secretory/RAS-Secretory|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

URB1 NHS NTN1 MUC5AC

4.27e-051774940f210cfb61b873c5fd77dc17eadf4d017306500e
ToppCellChildren_(3_yrs)-Immune-B_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TLR10 PLEKHG1 DTX1 BTLA

4.56e-0518049440a12eb852373ae3d7c8d9bca376b0ae99f724b3
ToppCellFetal_29-31_weeks-Immune-B_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TLR10 PLEKHG1 DTX1 BTLA

4.66e-0518149457f20341c3e9f9f6ed5b6c181605ad35bae91414
ToppCellnucseq-Immune-Lymphocytic_B-Lymphocytic_B-B|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TLR10 PLEKHG1 DTX1 BTLA

4.66e-051814948d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCellB_cells-Naive_B_cells_|World / Immune cells in Kidney/Urine in Lupus Nephritis

TLR10 PLEKHG1 DTX1 BTLA

4.76e-0518249463c3b63315276b66667d49fab09661ac320e7a36
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

PLEKHG1 DTX1 NTN1 ELMO1

4.86e-05183494bc98df870de65aff6dab295c24cbc199c7f2aa15
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 DTX1 NEB

4.86e-0518349401664fce6b70a02c9d39d747b6a6aabc86d57bc2
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 DTX1 NEB

5.18e-05186494d7d884ff4184636081c350d29f797bd923c6a3b4
ToppCell10x5'-Liver-Lymphocytic_B-Naive_B_cells|Liver / Manually curated celltypes from each tissue

TLR10 PLEKHG1 DTX1 BTLA

5.18e-0518649423efdcedbe67f5e6c59106e052f570cd0338f1c1
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-8|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 DTX1 BTLA

5.29e-05187494c10d6a774b3e83f64e47b9ad08f5d6b0dc60d163
ToppCellImmune-B_cell|World / Lineage, Cell type, age group and donor

TLR10 PLEKHG1 DTX1 BTLA

5.29e-05187494795690c6306c366e733279491138d0cd9b469b21
ToppCellHealthy-B_naive|World / disease group, cell group and cell class

TLR10 PLEKHG1 DTX1 BTLA

5.51e-051894941e533a43f739ff295740cf2b25479756dfb8e595
ToppCellcellseq2-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-VEC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

PLEKHG1 ZNF267 MED12 IQCK

5.51e-05189494bccb3481ffed597c845fe860da658505316105b5
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-B_lymphocytic-naive_B_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

TLR10 PLEKHG1 DTX1 BTLA

5.63e-05190494a7498fe55b7810c482291db782dc5282675d246a
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TLR10 PLEKHG1 DTX1 BTLA

5.63e-05190494112706d64ee73b55dcf76f33ca064ab1fc6ce87f
ToppCell3'_v3-bone_marrow-Lymphocytic_B-Naive_B_cells|bone_marrow / Manually curated celltypes from each tissue

TLR10 PLEKHG1 DTX1 BTLA

5.63e-051904943d45d5011305f13634013d9eeb98f235517dd54e
ToppCellControl-Lymphoid_B-B_intermediate|Control / Disease group, lineage and cell class

TLR10 PLEKHG1 DTX1 BTLA

5.74e-051914940082181dbc39c7c4fd3aa34c3ed61439548e844b
ToppCellFetal_29-31_weeks-Immune-B_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TLR10 PLEKHG1 DTX1 BTLA

5.74e-0519149484452125d1b5b76974e3f9126f611eff16d45c25
ToppCellHealthy-B_naive|Healthy / disease group, cell group and cell class

TLR10 PLEKHG1 DTX1 BTLA

5.86e-051924945fddf679dcc9c0077d6bfe04c1e602863fb959eb
ToppCell3'_v3-bone_marrow-Lymphocytic_B|bone_marrow / Manually curated celltypes from each tissue

TLR10 PLEKHG1 DTX1 BTLA

5.86e-051924948a284b6e499f5a3c116d5551430f00ecad4a3681
ToppCellHealthy/Control-B_intermediate|World / Disease group and Cell class

TLR10 PLEKHG1 DTX1 BTLA

5.86e-051924942266aa695955f5d885708e6bc0d5a8827c306223
ToppCellCOVID_non-vent-Lymphocytic-B_cell-|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

TLR10 PLEKHG1 DTX1 BTLA

5.98e-0519349491955c3773c9729a96e82f240f06b072367970d9
ToppCellCOVID_non-vent-Lymphocytic-B_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

TLR10 PLEKHG1 DTX1 BTLA

5.98e-0519349432d139f922cd19adc1cc1e0e9a828115be9945d6
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

URB1 NHS NTN1 MUC5AC

6.10e-05194494e0228f593c3493175962a4817500d4337ddc4e88
ToppCellControl-Lymphoid_B-B_naive|Control / Disease group, lineage and cell class

TLR10 PLEKHG1 DTX1 BTLA

6.10e-051944944f9600960a287cfc020c06b4af3528d4e5797916
ToppCellHealthy/Control-B_intermediate|Healthy/Control / Disease group and Cell class

TLR10 PLEKHG1 DTX1 BTLA

6.10e-051944948a4260eeccb4924c392798b1ffa23cdd3a4062e9
ToppCell10x5'-bone_marrow-Lymphocytic_B|bone_marrow / Manually curated celltypes from each tissue

TLR10 PLEKHG1 DTX1 BTLA

6.22e-05195494bcbf0305ca9337a6f3021178dbb47a7fbf1030a4
ToppCell10x3'2.3-week_17-19-Mesenchymal_myocytic-stroma-muscle|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

KANK4 NEB TRMT5 MEGF10

6.22e-0519549480b973d2a23ef9b101c90e1635e68c9a3f78f65d
ToppCellHealthy-B_intermediate|World / disease group, cell group and cell class

TLR10 PLEKHG1 DTX1 NEB

6.22e-051954949de79e0bdd9063ae65e5edb89cc3fe6f9a8173bc
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 DTX1 BTLA

6.35e-05196494fcbfd8c4771d99a45fc53e482ef98edabe8ef591
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

TLR10 PLEKHG1 DTX1 BTLA

6.35e-05196494f45cb8f714ae7ac800768df65f299b98a2d42962
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TLR10 PLEKHG1 DTX1 BTLA

6.35e-05196494d7e6c89cb49933b4a86d26d15f6772f2481d37ef
ToppCellcontrol-B_naive|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TLR10 PLEKHG1 DTX1 BTLA

6.47e-05197494559650fb53f18ecae4cfaa8221e978ae3fb63e06
ToppCellBronchial-NucSeq-Immune_Lymphocytic-B-B_cell|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

TLR10 PLEKHG1 BTLA ELMO1

6.47e-05197494da61afba697ec49ca86e062d35a825280da558ac
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 DTX1 NTN1 ELMO1

6.60e-051984949ab0db78394e730f6866b2db80047149024ad5f6
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 NHS NTN1 MUC5AC

6.60e-05198494af399569c718f5fd971d73a7926768c9311002a3
ToppCellParenchymal-NucSeq-Endothelial-Endothelia_lymphatic-Endothelia_Lymphatic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHG1 DTX1 NTN1 ELMO1

6.60e-05198494e47d0e2c6353315c85d7007742bb16b0f05795ed
ToppCellControl-Control-Lymphocyte-B-B_intermediate|Control / Disease, condition lineage and cell class

TLR10 PLEKHG1 DTX1 BTLA

6.73e-05199494ee6f07eec7edfe41d2f7fcb0b509ce00e99a6a95
ToppCellCOVID-19-COVID-19_Mild-Lymphocyte-B-B_naive|COVID-19_Mild / Disease, condition lineage and cell class

TLR10 PLEKHG1 DTX1 BTLA

6.86e-05200494e6a43eff47195e1d39530ad49ad908fc06a8b038
ToppCellControl-Control-Lymphocyte-B-B_naive|Control / Disease, condition lineage and cell class

TLR10 PLEKHG1 DTX1 BTLA

6.86e-0520049415e4b9956b9a0c2e6927a802e86e1cb4bb18b89a
ToppCellInfluenza-Influenza_Severe-Lymphocyte-B|Influenza_Severe / Disease, condition lineage and cell class

TLR10 PLEKHG1 DTX1 BTLA

6.86e-05200494bf238a0a074d6c5cba8cb73d3b715ee701a612b6
ToppCellLA-10._Endothelium_II|World / Chamber and Cluster_Paper

PLEKHG1 XPNPEP1 ELMO1

3.77e-04128493071becbe97598c2b65580b0989eb664d6fd6c85a
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-1|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 USF3 BTLA

4.03e-04131493a3a086ce6e69707ca6a042f3b15c130f81909acb
ToppCellPND01-03-samps-Mesenchymal-Pericyte-pericyte_E|PND01-03-samps / Age Group, Lineage, Cell class and subclass

AGL KANK4 ARMCX6

4.40e-0413549335928195cf34f055b353562c96f451aef2344d64
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_activate-7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PLEKHG1 BBS1 BTLA

4.69e-0413849376be06136c83c167cedece7515228ed4d29dd1f0
ToppCellHealthy-B_cell|World / disease group, cell group and cell class

PLEKHG1 BTLA NEB

5.53e-04146493588359d3df6ad7090b7fa6c7f8d29cc1717e7f4f
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_1|343B / Donor, Lineage, Cell class and subclass (all cells)

CHAF1B ANKS1B MUC5AC

5.87e-041494932a7f71da51c85e04de2123164914122480e60d66
ToppCellSmart-seq2-bone_marrow_(Smart-seq2)-lymphocytic-B_lymphocytic-naive_B_cell|bone_marrow_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PLEKHG1 DTX1 BTLA

6.10e-041514930f8f07e44c6edaf09574930b416fdce14d67095a
ToppCellDendritic_Cells-IPF_03|World / lung cells shred on cell class, cell subclass, sample id

TLR10 DTX1 BTLA

6.10e-04151493e089bf197ed60e7243160521d4390d4b40a3832b
ToppCellCOVID-19_Mild|World / 5 Neutrophil clusters in COVID-19 patients

USF3 DDX60L CFAP57

6.21e-041524932ff0980dfd8d430cca14649151d856edef115720
ToppCellHealthy-B_cell|Healthy / disease group, cell group and cell class

PLEKHG1 BTLA NEB

6.33e-041534937f82cd61b3f1ebaee3e4bbf68ba858a67c2065e7
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)

DTX1 BTLA IQCK

6.83e-0415749329622bac6b16bb39cec4319bf4c4f92d33345e8a
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-1M-Radial_glial-gliogenic/outer_RGCs_and_astrocytes|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.

KANK4 BBS1 SORCS3

6.83e-041574932c1219ee19a6246a3b9f5c2c1a37f26ea934a822
ToppCellLPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CHAF1B NHS IQCK

6.95e-041584937f5426585d0d299d2b48e5fcb349950feffdef33
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HYAL4 CFAP57 IQCK

6.95e-04158493f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HYAL4 CFAP57 IQCK

6.95e-041584938c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCell10x5'-Lung-Lymphocytic_B-ABC_aged-B_memory|Lung / Manually curated celltypes from each tissue

TLR10 PLEKHG1 SMIM18

7.08e-04159493d3202ddc291b8686dbe67690df13c7daffec2199
ToppCellSevere-B_naive-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

USF3 BTLA NSMCE3

7.08e-041594932881b054bbeb479221ee3c38bbd9b0815b123579
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HYAL4 BBS1 NTN1

7.21e-04160493174a4ab27114efcc63be36929b80680be3c35c9b
ToppCellPND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-NK-NK_prolif|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CHAF1B POPDC2 NEB

7.21e-041604935cc1b75e3c20d83112b3aa2f3c749a6c73910a2d
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTX1 ANKS1B BTLA

7.34e-0416149398be0cf8228496b31f7f3e0efd8787e95eb626d1
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

DTX1 ANKS1B BTLA

7.34e-041614937af3b0d4fc7967f6b3e2d255d23fd8b1fd01a7af
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KANK4 SORCS3 MEGF10

7.48e-04162493d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANKS1B NEB MEGF10

7.48e-04162493bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KANK4 SORCS3 MEGF10

7.48e-04162493eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USF3 DTX1 ANKS1B

7.48e-04162493e81dec1db8e5a808d96e58410c91961e5d065c94
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KANK4 SORCS3 MEGF10

7.48e-041624935bbd7130d4dad9035e73a439dda568195c136f31
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-13|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 PLEKHG1 CFAP57

7.48e-0416249328b3a6ae5519a267eefb70436d3190a387d027b9
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USF3 DTX1 ANKS1B

7.48e-04162493d19b469f64c9064cfb82dadb6c8135e28949a02a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

KANK4 SORCS3 MEGF10

7.48e-04162493e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellfacs-Lung-Endomucin_-18m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USF3 DTX1 ANKS1B

7.48e-0416249310c2aa047f33f48e4abe676236bbdb593079dd1d
ToppCell10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_naive|bone_marrow / Manually curated celltypes from each tissue

TLR10 PLEKHG1 NEB

7.48e-0416249344832055b11a789e320c802aadb345e065defc8f
ToppCellmetastatic_Brain-B_lymphocytes-Undetermined|metastatic_Brain / Location, Cell class and cell subclass

TLR10 NSMCE3 ELMO1

7.61e-041634934eac7fd8acdb7f09ce739335f22a879f9b8febfb
ToppCell10x_3'_v2v3-Non-neoplastic-Myeloid-Mono-Mono_naive-D|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

XPNPEP1 POPDC2 NEB

7.61e-041634934be3158f2a0ab460cfea8080a7370922910b5da9
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

TLR10 NTN1 BTLA

7.75e-0416449343045879505774ac0d9b7f760557955564f06d00
ToppCellBasal_cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

PLEKHG1 NHS ADPRHL1

7.75e-04164493b15a26130a1ea1b370b6e3be21f02a0d6aaf6b3c
ToppCell10x5'-blood-Lymphocytic_B-ABC_aged-B_memory|blood / Manually curated celltypes from each tissue

TLR10 PLEKHG1 DTX1

7.75e-041644930424b23fc540580e7c15c50a7a03dff7c25014fa
ToppCellLV-16._Neuronal|World / Chamber and Cluster_Paper

SORCS3 MEGF10 ELMO1

7.88e-041654936ed52cb756d21addf46c7f6c457458b01339fe04
ToppCelltumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_Tfh|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass

NHS BTLA NSMCE3

8.02e-04166493c73fce59256ad501864f44f76cfae2fc33b3777e
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLEKHG1 ANGEL1 ELMO1

8.02e-041664938e2faca6a2e76a625de04d6098aa6f98911945c6
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

KANK4 NTN1 NEB

8.02e-041664936a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCellAdult-Epithelial-lung_goblet_cell-D122|Adult / Lineage, Cell type, age group and donor

NHS NTN1 MUC5AC

8.16e-041674936efbb2ef6adc8da5dd67210969f825f5cc8ed022
ToppCellfacs-Trachea-3m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADPRHL1 POPDC2 NEB

8.16e-04167493d78356bf0c473816dbabaee51984940bd822f84e
ToppCellmild-Lymphocytic-B_cells_2|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PLEKHG1 DTX1 BTLA

8.16e-041674930811f7559c2a7151693771e52e14af3978997118
ToppCellLA-16._Neuronal|World / Chamber and Cluster_Paper

PLEKHG1 MEGF10 ELMO1

8.31e-041684932fd1fd2a16ac1c5eb028f93cc3a2477c7747693e
ToppCellLA-16._Neuronal|LA / Chamber and Cluster_Paper

PLEKHG1 MEGF10 ELMO1

8.31e-04168493c55bbfbde8bb954f1cb9af82007bdd1f8070fee3
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TLR10 NTN1 BTLA

8.45e-04169493e3410ccb3f85811c75694e286115803911169a2f
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KANK4 BTLA NEB

8.45e-04169493befb9b1618ea30fbf8983bcc493853da53b809c3
ToppCellmetastatic_Lymph_Node-Myeloid_cells-Microglia/Mac|Myeloid_cells / Location, Cell class and cell subclass

NRDE2 NEB MUC5AC

8.45e-04169493dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_11|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 NTN1 BTLA

8.45e-04169493a4f610d07c3ba5537f4497f523669b914f7eddc1
DiseaseBardet-Biedl syndrome (implicated_via_orthology)

BBS1 BBS4

1.35e-0411472DOID:1935 (implicated_via_orthology)
DiseaseBardet-Biedl syndrome 1 (disorder)

BBS1 BBS4

3.33e-0417472C2936862
DiseaseBardet-Biedl syndrome

BBS1 BBS4

3.74e-0418472cv:C0752166
DiseaseCiliopathies

CRELD1 BBS1 BBS4

7.25e-04110473C4277690
Diseaseposterior urethral valve

UBR2 MEGF10

9.81e-0429472MONDO_0019640

Protein segments in the cluster

PeptideGeneStartEntry
NQKDWEISHNLGVCY

BBS4

131

Q96RK4
QLNFIAPDKHEYCIW

ELMO1

651

Q92556
WNIHGKESCDVQLYI

BTLA

26

Q7Z6A9
CEIAWHNKEPVYSLD

CHAF1B

6

Q13112
PYEHKNTWSAQNCKN

ARMCX6

106

Q7L4S7
LNNPHNLTCWQSENY

NTN1

111

O95631
ACDFLTEWLYNQNPK

IQCK

166

Q8N0W5
QYWQHHPEKLIFQSC

ANKS1B

1046

Q7Z6G8
LNLEDPNVCSHWESY

MEGF10

26

Q96KG7
FHKQQEAPDLFQWLC

CRELD1

121

Q96HD1
AKAQLLQCQHHPAWY

KIAA0100

1601

Q14667
LNYVKEELHQLQCEW

MDN1

3251

Q9NU22
KPHPQEEYLDCLWAQ

NCBP1

221

Q09161
EPQNYLAHTWVADDK

CFAP57

196

Q96MR6
CLSQDWKLFLEQHYP

DDX60L

126

Q5H9U9
KLNQENEHIYNLWCS

CCDC47

196

Q96A33
GNHLYKWKQIPDCEN

IFNAR1

271

P17181
HPNNTALWQKYLLFC

NRDE2

411

Q9H7Z3
VNNWRDDQYLDDCKP

MED12

1511

Q93074
PCSLSVENEKYAQHW

MUC5AC

616

P98088
CITIQNAYEKQHPWL

DTX1

126

Q86Y01
QKYPNAELAWCQEEH

OGDH

946

Q02218
AELAWCQEEHKNQGY

OGDH

951

Q02218
ISSDCNHLLWNYKLN

GLG1

151

Q92896
AWNAPTDQCLIKYNL

HYAL4

51

Q2M3T9
GCAQLKPNNYLLAWH

ADPRHL1

106

Q8NDY3
EESYCKQWLNANPSR

INPP5B

711

P32019
LQEQWNCLEHGYPEL

KANK4

571

Q5T7N3
CISKNEWIQFNHPYT

KLHDC2

301

Q9Y2U9
SNEANSKWLDAHYDP

BBS1

16

Q8NFJ9
DLKNEVWYQKCHDPV

PRIMPOL

436

Q96LW4
NDLNPESHKWLLYNC

TRMT5

326

Q32P41
QNLLQHKNDENCSWP

TLR10

406

Q9BXR5
LPDCAWQDYLDHKRQ

NHS

821

Q6T4R5
CTKEDYQTWHLLNQG

SORCS3

696

Q9UPU3
AGHEEYLNTWKNRCE

IQCA1L

396

A6NCM1
VQKIYPFHDNWNTAC

SMIM18

21

P0DKX4
DHCLNKEVWQESGVY

URB1

471

O60287
NAHCVDYETQNPKWA

AGAP5

476

A6NIR3
PDILCLQEVQEDHYW

ANGEL1

291

Q9UNK9
SLTDKECDWLNNYHL

XPNPEP1

576

Q9NQW7
EEWEHLEPAQKNLYQ

ZNF267

16

Q14586
WKQDVEGAVYHLANC

POPDC2

21

Q9HBU9
KANDICLYDDPTIHW

USF3

111

Q68DE3
HNQDPKDWPAQYCEA

NSMCE3

271

Q96MG7
QPNKENWCQDHLYNS

PLEKHG1

1151

Q9ULL1
AWKEGPYCQKHELNT

UBR2

156

Q8IWV8
KPYCNEIHAQAQLWL

UBR4

4046

Q5T4S7
NNKDNPEIWCHYLRL

ZFC3H1

1396

O60293
KWIQEHPECAYNLVN

AGL

226

P35573
YKNYLHQWTCLPDQN

NEB

2381

P20929
NYLHQWTCLPDQSDV

NEB

2626

P20929
DYKNYLHQWTCLPDQ

NEB

2866

P20929
KNYLHEWTCLPDQND

NEB

3111

P20929