Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein antigen binding

PLG LPA

2.94e-0416322GO:1990405
GeneOntologyMolecularFunctionapolipoprotein binding

PLG LPA

4.64e-0420322GO:0034185
GeneOntologyBiologicalProcessregulation of blood coagulation

TMX1 PLG EMILIN1 LPA

1.32e-0591334GO:0030193
GeneOntologyBiologicalProcessregulation of hemostasis

TMX1 PLG EMILIN1 LPA

1.43e-0593334GO:1900046
GeneOntologyBiologicalProcessregulation of coagulation

TMX1 PLG EMILIN1 LPA

1.63e-0596334GO:0050818
GeneOntologyBiologicalProcesspositive regulation of hemostasis

PLG EMILIN1 LPA

1.63e-0531333GO:1900048
GeneOntologyBiologicalProcesspositive regulation of blood coagulation

PLG EMILIN1 LPA

1.63e-0531333GO:0030194
GeneOntologyBiologicalProcesspositive regulation of coagulation

PLG EMILIN1 LPA

2.16e-0534333GO:0050820
GeneOntologyBiologicalProcesspositive regulation of fibrinolysis

PLG LPA

2.47e-055332GO:0051919
GeneOntologyBiologicalProcessplacenta blood vessel development

PLG LPA NOTCH2

4.73e-0544333GO:0060674
GeneOntologyBiologicalProcesstrans-synaptic signaling by BDNF, modulating synaptic transmission

PLG LPA

5.19e-057332GO:0099183
GeneOntologyBiologicalProcesstrans-synaptic signaling by BDNF

PLG LPA

6.91e-058332GO:0099191
GeneOntologyBiologicalProcessregulation of wound healing

TMX1 PLG EMILIN1 LPA

1.38e-04166334GO:0061041
GeneOntologyBiologicalProcessnegative regulation of blood coagulation

TMX1 PLG LPA

1.82e-0469333GO:0030195
GeneOntologyBiologicalProcessnegative regulation of hemostasis

TMX1 PLG LPA

1.90e-0470333GO:1900047
GeneOntologyBiologicalProcessnegative regulation of coagulation

TMX1 PLG LPA

2.06e-0472333GO:0050819
GeneOntologyBiologicalProcesspositive regulation of wound healing

PLG EMILIN1 LPA

2.15e-0473333GO:0090303
GeneOntologyBiologicalProcessnegative regulation of fibrinolysis

PLG LPA

2.23e-0414332GO:0051918
GeneOntologyBiologicalProcessneuron projection morphogenesis

PPP3CB SEMA5B PLXNB2 UNC13A NOTCH2 CNTNAP1 LAMA1

2.31e-04802337GO:0048812
GeneOntologyBiologicalProcessaxonogenesis

PPP3CB SEMA5B PLXNB2 NOTCH2 CNTNAP1 LAMA1

2.45e-04566336GO:0007409
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

PPP3CB SEMA5B PLXNB2 UNC13A NOTCH2 CNTNAP1 LAMA1

2.62e-04819337GO:0120039
GeneOntologyBiologicalProcesscell projection morphogenesis

PPP3CB SEMA5B PLXNB2 UNC13A NOTCH2 CNTNAP1 LAMA1

2.76e-04826337GO:0048858
GeneOntologyBiologicalProcessextracellular matrix organization

ADAMTSL1 PLG EMILIN1 LPA LAMA1

3.09e-04377335GO:0030198
GeneOntologyBiologicalProcesstube morphogenesis

PLG CSMD1 THSD7A PLXNB2 EMILIN1 LPA NOTCH2 LAMA1

3.12e-041125338GO:0035239
GeneOntologyBiologicalProcessextracellular structure organization

ADAMTSL1 PLG EMILIN1 LPA LAMA1

3.13e-04378335GO:0043062
GeneOntologyBiologicalProcessexternal encapsulating structure organization

ADAMTSL1 PLG EMILIN1 LPA LAMA1

3.17e-04379335GO:0045229
GeneOntologyBiologicalProcessregulation of response to wounding

TMX1 PLG EMILIN1 LPA

3.84e-04217334GO:1903034
GeneOntologyBiologicalProcesstrophoblast giant cell differentiation

PLG LPA

4.17e-0419332GO:0060707
GeneOntologyBiologicalProcessregulation of fibrinolysis

PLG LPA

4.17e-0419332GO:0051917
GeneOntologyBiologicalProcesspositive regulation of response to wounding

PLG EMILIN1 LPA

4.39e-0493333GO:1903036
GeneOntologyBiologicalProcesscell morphogenesis

PPP3CB SEMA5B PLXNB2 UNC13A NOTCH2 ARAP1 CNTNAP1 LAMA1

4.66e-041194338GO:0000902
GeneOntologyBiologicalProcessaxon development

PPP3CB SEMA5B PLXNB2 NOTCH2 CNTNAP1 LAMA1

4.80e-04642336GO:0061564
GeneOntologyBiologicalProcessnegative regulation of wound healing

TMX1 PLG LPA

5.12e-0498333GO:0061045
GeneOntologyBiologicalProcessvasculature development

PLG PPP3CB THSD7A EMILIN1 LPA NOTCH2 LAMA1

7.22e-04969337GO:0001944
GeneOntologyBiologicalProcessmononuclear cell migration

PLG MED23 EMILIN1 LPA

7.36e-04258334GO:0071674
GeneOntologyBiologicalProcessblood coagulation

TMX1 PLG EMILIN1 LPA

7.57e-04260334GO:0007596
GeneOntologyBiologicalProcessneuron projection development

PPP3CB SEMA5B PLXNB2 UNC13A NOTCH2 ROR1 CNTNAP1 LAMA1

7.59e-041285338GO:0031175
GeneOntologyBiologicalProcesstrans-synaptic signaling, modulating synaptic transmission

PLG LPA

7.88e-0426332GO:0099550
GeneOntologyBiologicalProcesscoagulation

TMX1 PLG EMILIN1 LPA

8.24e-04266334GO:0050817
GeneOntologyBiologicalProcesshemostasis

TMX1 PLG EMILIN1 LPA

8.48e-04268334GO:0007599
GeneOntologyBiologicalProcessfibrinolysis

PLG LPA

9.81e-0429332GO:0042730
GeneOntologyBiologicalProcesslabyrinthine layer blood vessel development

PLG LPA

9.81e-0429332GO:0060716
GeneOntologyBiologicalProcesswound healing

TMX1 PLG EMILIN1 LPA NOTCH2

1.04e-03493335GO:0042060
GeneOntologyBiologicalProcessnegative regulation of response to wounding

TMX1 PLG LPA

1.06e-03126333GO:1903035
GeneOntologyBiologicalProcessprotein processing

MEP1A PLG SPRTN LPA

1.07e-03285334GO:0016485
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

PPP3CB SEMA5B PLXNB2 NOTCH2 CNTNAP1 LAMA1

1.07e-03748336GO:0048667
GeneOntologyBiologicalProcessmuscle cell cellular homeostasis

PLG LPA

1.12e-0331332GO:0046716
GeneOntologyBiologicalProcesstube development

PLG CSMD1 THSD7A PLXNB2 EMILIN1 LPA NOTCH2 LAMA1

1.34e-031402338GO:0035295
GeneOntologyBiologicalProcesscell differentiation involved in embryonic placenta development

PLG LPA

1.35e-0334332GO:0060706
GeneOntologyBiologicalProcessembryo development

OCRL PLG CUBN PLXNB2 POLE LPA NOTCH2 LAMA1

1.57e-031437338GO:0009790
GeneOntologyBiologicalProcessblood vessel morphogenesis

PLG THSD7A EMILIN1 LPA NOTCH2 LAMA1

1.68e-03817336GO:0048514
GeneOntologyBiologicalProcessneuron development

PPP3CB SEMA5B PLXNB2 UNC13A NOTCH2 ROR1 CNTNAP1 LAMA1

1.76e-031463338GO:0048666
GeneOntologyBiologicalProcessanatomical structure formation involved in morphogenesis

PLG PPP3CB THSD7A PLXNB2 EMILIN1 LPA NOTCH2 CNTNAP1

1.92e-031483338GO:0048646
GeneOntologyBiologicalProcessregulation of platelet aggregation

TMX1 EMILIN1

2.05e-0342332GO:0090330
GeneOntologyBiologicalProcessmuscle structure development

PLG PPP3CB LPA NOTCH2 CNTNAP1 LAMA1

2.15e-03858336GO:0061061
GeneOntologyCellularComponentcollagen-containing extracellular matrix

ADAMTSL1 PLG PLXNB2 EMILIN1 LPA LAMA1

1.60e-04530336GO:0062023
GeneOntologyCellularComponentprotein complex involved in cell-matrix adhesion

EMILIN1 LAMA1

3.24e-0417332GO:0098637
GeneOntologyCellularComponentextracellular matrix

ADAMTSL1 PLG PLXNB2 EMILIN1 LPA LAMA1

5.01e-04656336GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

ADAMTSL1 PLG PLXNB2 EMILIN1 LPA LAMA1

5.10e-04658336GO:0030312
GeneOntologyCellularComponentGolgi-associated vesicle

OCRL CUBN UNC13A

7.65e-04114333GO:0005798
GeneOntologyCellularComponentcell surface

CLEC9A PLG CUBN PLXNB2 LPA NOTCH2 ROR1

1.49e-031111337GO:0009986
GeneOntologyCellularComponentmediator complex

MED23 MED13

1.55e-0337332GO:0016592
GeneOntologyCellularComponentreceptor complex

CUBN PLXNB2 EMILIN1 NOTCH2 ROR1

2.03e-03581335GO:0043235
MousePhenoabnormal mammary gland connective tissue morphology

PLG LPA

3.87e-062282MP:0009507
MousePhenoesophageal ulcer

PLG LPA

3.87e-062282MP:0004547
MousePhenoduodenal ulcer

PLG LPA

3.87e-062282MP:0003273
MousePhenoperianal ulcer

PLG LPA

3.87e-062282MP:0005035
MousePhenoectropion

PLG LPA

3.87e-062282MP:0006164
MousePhenoabsent cornea epithelium

PLG LPA

1.16e-053282MP:0020856
MousePhenoincreased circulating fibrinogen level

PLG LPA

2.32e-054282MP:0012331
MousePhenoproctitis

PLG LPA

2.32e-054282MP:0003305
MousePhenogastric ulcer

PLG LPA

5.77e-056282MP:0003282
MousePhenoincreased acute phase protein level

PLG LPA

8.07e-057282MP:0014499
MousePhenoabnormal conjunctival epithelium morphology

PLG LPA

8.07e-057282MP:0004481
MousePhenovenoocclusion

PLG LPA

8.07e-057282MP:0006137
MousePhenopeptic ulcer

PLG LPA

8.07e-057282MP:0003301
MousePhenodecreased keratinocyte migration

PLG LPA

1.08e-048282MP:0012194
MousePhenoabnormal circulating fibrinogen level

PLG LPA

1.08e-048282MP:0010213
MousePhenodecreased susceptibility to induced choroidal neovascularization

PLG LPA

1.72e-0410282MP:0003434
MousePhenoabnormal kidney thrombosis

PLG LPA

1.72e-0410282MP:0011507
MousePhenoabnormal keratinocyte migration

PLG LPA

2.10e-0411282MP:0012192
MousePhenoabnormal anus morphology

PLG LPA

2.98e-0413282MP:0005034
MousePhenoabnormal conjunctiva morphology

PLG LPA

2.98e-0413282MP:0001310
MousePhenoabnormal chorion morphology

CUBN MED23 NOTCH2

4.24e-0474283MP:0002836
MousePhenoincreased hepatocyte proliferation

PLG LPA

5.16e-0417282MP:0003893
MousePhenolactation failure

PLG LPA

5.16e-0417282MP:0010249
MousePhenochoroidal neovascularization

PLG LPA

6.48e-0419282MP:0005546
MousePhenoabnormal involution of the mammary gland

PLG LPA

1.04e-0324282MP:0006271
MousePhenointestinal ulcer

PLG LPA

1.04e-0324282MP:0000512
MousePhenodecreased pulmonary respiratory rate

UNC13A ARAP1

1.13e-0325282MP:0005574
MousePhenoabnormal acute phase protein level

PLG LPA

1.13e-0325282MP:0010211
MousePhenoconjunctivitis

PLG LPA

1.22e-0326282MP:0001852
MousePhenoabnormal eye vasculature morphology

TRIM68 PLG LPA NOTCH2 LAMA1

1.26e-03415285MP:0031346
MousePhenoabnormal choroid vasculature morphology

PLG LPA

1.32e-0327282MP:0006237
MousePhenoabnormal anal canal morphology

PLG LPA

1.32e-0327282MP:0009053
MousePhenoabnormal mammary gland growth during lactation

PLG LPA

1.42e-0328282MP:0006270
MousePhenorectal prolapse

PLG LPA

1.52e-0329282MP:0000493
DomainKringle

PLG LPA ROR1

3.06e-0617323IPR000001
DomainKringle_CS

PLG LPA ROR1

3.06e-0617323IPR018056
DomainKRINGLE_2

PLG LPA ROR1

3.06e-0617323PS50070
DomainKringle

PLG LPA ROR1

3.06e-0617323PF00051
DomainKRINGLE_1

PLG LPA ROR1

3.06e-0617323PS00021
DomainKR

PLG LPA ROR1

3.06e-0617323SM00130
DomainEGF_1

MEP1A NTN5 CUBN NOTCH2 CNTNAP1 LAMA1

4.11e-06255326PS00022
DomainEGF_2

MEP1A NTN5 CUBN NOTCH2 CNTNAP1 LAMA1

5.13e-06265326PS01186
DomainKringle-like

PLG LPA ROR1

2.19e-0532323IPR013806
DomainConA-like_dom

MEP1A TRIM68 MAMDC4 CNTNAP1 LAMA1

3.29e-05219325IPR013320
DomainEGF

MEP1A CUBN NOTCH2 CNTNAP1 LAMA1

4.61e-05235325SM00181
DomainEGF-like_dom

MEP1A CUBN NOTCH2 CNTNAP1 LAMA1

6.07e-05249325IPR000742
DomainEGF

MEP1A CUBN NOTCH2 CNTNAP1

6.13e-05126324PF00008
DomainEGF-like_CS

MEP1A CUBN NOTCH2 CNTNAP1 LAMA1

7.58e-05261325IPR013032
DomainTSP_1

ADAMTSL1 THSD7A SEMA5B

1.69e-0463323PF00090
DomainTSP1

ADAMTSL1 THSD7A SEMA5B

1.86e-0465323SM00209
DomainTSP1_rpt

ADAMTSL1 THSD7A SEMA5B

1.86e-0465323IPR000884
DomainTSP1

ADAMTSL1 THSD7A SEMA5B

1.86e-0465323PS50092
DomainMAM_1

MEP1A MAMDC4

3.36e-0416322PS00740
DomainMAM

MEP1A MAMDC4

3.81e-0417322SM00137
DomainMAM

MEP1A MAMDC4

4.28e-0418322PF00629
DomainMAM_dom

MEP1A MAMDC4

4.28e-0418322IPR000998
DomainMAM_2

MEP1A MAMDC4

4.28e-0418322PS50060
DomainRho_GTPase_activation_prot

OCRL PLXNB2 ARAP1

4.54e-0488323IPR008936
DomainEGF_3

MEP1A CUBN NOTCH2 CNTNAP1

6.66e-04235324PS50026
DomainEGF_LAM_2

NTN5 LAMA1

1.20e-0330322PS50027
DomainEGF_LAM_1

NTN5 LAMA1

1.20e-0330322PS01248
DomainSema

SEMA5B PLXNB2

1.28e-0331322SM00630
DomainSemap_dom

SEMA5B PLXNB2

1.28e-0331322IPR001627
DomainSema

SEMA5B PLXNB2

1.28e-0331322PF01403
DomainSEMA

SEMA5B PLXNB2

1.28e-0331322PS51004
DomainPSI

SEMA5B PLXNB2

1.37e-0332322PF01437
DomainPlexin_repeat

SEMA5B PLXNB2

1.37e-0332322IPR002165
DomainLaminin_EGF

NTN5 LAMA1

1.63e-0335322PF00053
DomainEGF_Lam

NTN5 LAMA1

1.63e-0335322SM00180
DomainLAM_G_DOMAIN

CNTNAP1 LAMA1

1.92e-0338322PS50025
DomainLaminin_EGF

NTN5 LAMA1

1.92e-0338322IPR002049
DomainLaminin_G_2

CNTNAP1 LAMA1

2.13e-0340322PF02210
DomainGrowth_fac_rcpt_

CUBN NOTCH2 LAMA1

2.37e-03156323IPR009030
DomainPSI

SEMA5B PLXNB2

2.57e-0344322IPR016201
DomainLamG

CNTNAP1 LAMA1

2.57e-0344322SM00282
DomainPSI

SEMA5B PLXNB2

2.81e-0346322SM00423
DomainCUB

CUBN CSMD1

3.18e-0349322PF00431
DomainCUB

CUBN CSMD1

3.31e-0350322SM00042
Domain-

CUBN CSMD1

3.57e-03523222.60.120.290
DomainCUB

CUBN CSMD1

3.71e-0353322PS01180
DomainIg_I-set

LRIT2 ADAMTSL1 ROR1

4.14e-03190323IPR013098
DomainI-set

LRIT2 ADAMTSL1 ROR1

4.14e-03190323PF07679
DomainCUB_dom

CUBN CSMD1

4.28e-0357322IPR000859
DomainLaminin_G

CNTNAP1 LAMA1

4.43e-0358322IPR001791
DomainRhoGAP

OCRL ARAP1

5.04e-0362322SM00324
DomainRhoGAP

OCRL ARAP1

5.20e-0363322PF00620
DomainRHOGAP

OCRL ARAP1

5.37e-0364322PS50238
DomainRhoGAP_dom

OCRL ARAP1

5.37e-0364322IPR000198
Domain-

OCRL ARAP1

5.37e-03643221.10.555.10
DomainIGc2

LRIT2 ADAMTSL1 ROR1

7.45e-03235323SM00408
DomainIg_sub2

LRIT2 ADAMTSL1 ROR1

7.45e-03235323IPR003598
PathwayREACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS

ADAMTSL1 THSD7A SEMA5B NOTCH2

6.83e-0668264M27303
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 THSD7A SEMA5B

4.87e-0539263M27417
PathwayREACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS

ADAMTSL1 THSD7A SEMA5B

4.87e-0539263MM15165
PathwayREACTOME_DISEASES_OF_METABOLISM

ADAMTSL1 CUBN THSD7A SEMA5B NOTCH2

8.17e-05250265M27554
PathwayREACTOME_DISEASES_OF_GLYCOSYLATION

ADAMTSL1 THSD7A SEMA5B NOTCH2

1.28e-04143264M27275
PathwayBIOCARTA_FIBRINOLYSIS_PATHWAY

PLG LPA

2.13e-0412262MM1398
PathwayBIOCARTA_PLATELETAPP_PATHWAY

PLG LPA

2.94e-0414262MM1458
PathwayREACTOME_DISSOLUTION_OF_FIBRIN_CLOT

PLG LPA

3.38e-0415262MM15450
PathwayWP_BDNF_PATHWAY

PLG LPA

3.86e-0416262MM15816
PathwayWP_BLOOD_CLOTTING_CASCADE

PLG LPA

8.08e-0423262MM15936
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL1 THSD7A SEMA5B

1.03e-03109263MM15164
PathwayREACTOME_O_LINKED_GLYCOSYLATION

ADAMTSL1 THSD7A SEMA5B

1.08e-03111263M27416
PathwayPID_SYNDECAN_4_PATHWAY

PLG LAMA1

1.57e-0332262M165
PathwayKEGG_AXON_GUIDANCE

PPP3CB SEMA5B PLXNB2

1.67e-03129263M5539
Pubmed

The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.

ADAMTSL1 PLG PLXNB2 EMILIN1 LPA LAMA1

1.35e-0816734622159717
Pubmed

Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.

ADAMTSL1 PLG PLXNB2 EMILIN1 LPA LAMA1

1.78e-0817534628071719
Pubmed

O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.

ADAMTSL1 CUBN THSD7A SEMA5B

8.81e-077534420637190
Pubmed

Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function.

PLG LPA

9.28e-07234221239499
Pubmed

Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice.

PLG LPA

9.28e-07234231690812
Pubmed

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer's disease.

PLG LPA

9.28e-07234230254165
Pubmed

Plasminogen-independent initiation of the pro-urokinase activation cascade in vivo. Activation of pro-urokinase by glandular kallikrein (mGK-6) in plasminogen-deficient mice.

PLG LPA

9.28e-07234210642175
Pubmed

Plasminogen mRNA induction in the mouse brain after kainate excitation: codistribution with plasminogen activator inhibitor-2 (PAI-2) mRNA.

PLG LPA

9.28e-07234212225871
Pubmed

Fibrinogen deficiency reduces vascular accumulation of apolipoprotein(a) and development of atherosclerosis in apolipoprotein(a) transgenic mice.

PLG LPA

9.28e-0723429770530
Pubmed

Plasminogen deficiency exacerbates skeletal muscle loss during mechanical unloading in developing mice.

PLG LPA

9.28e-07234238328826
Pubmed

Reduced transplant arteriosclerosis in plasminogen-deficient mice.

PLG LPA

9.28e-0723429819364
Pubmed

Plasminogen activation is required for the development of radiation-induced dermatitis.

PLG LPA

9.28e-07234230323258
Pubmed

Plasminogen deficiency suppresses pancreatic ductal adenocarcinoma disease progression.

PLG LPA

9.28e-07234237971174
Pubmed

The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.

PLG LPA

9.28e-0723429884337
Pubmed

Persistent corneal haze after excimer laser photokeratectomy in plasminogen-deficient mice.

PLG LPA

9.28e-07234210634603
Pubmed

Colonic Lesions, Cytokine Profiles, and Gut Microbiota in Plasminogen-Deficient Mice.

PLG LPA

9.28e-07234226473342
Pubmed

Thrombomodulin functions as a plasminogen receptor to modulate angiogenesis.

PLG LPA

9.28e-07234223943648
Pubmed

In vivo plasminogen deficiency reduces fat accumulation.

PLG LPA

9.28e-07234212083480
Pubmed

Polymorphonuclear leukocyte phagocytic function increases in plasminogen knockout mice.

PLG LPA

9.28e-07234218420257
Pubmed

Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

PLG LPA

9.28e-0723427705657
Pubmed

Nonfibrinolytic functions of plasminogen.

PLG LPA

9.28e-07234210816371
Pubmed

Nucleocytoplasmic coagulation: an injury-induced aggregation event that disulfide crosslinks proteins and facilitates their removal by plasmin.

PLG LPA

9.28e-07234223041318
Pubmed

Plasminogen alleles influence susceptibility to invasive aspergillosis.

PLG LPA

9.28e-07234218566672
Pubmed

A novel role for plasmin-mediated degradation of opsonizing antibody in the evasion of host immunity by virulent, but not attenuated, Francisella tularensis.

PLG LPA

9.28e-07234219752236
Pubmed

Plasminogen is a critical regulator of cutaneous wound healing.

PLG LPA

9.28e-07234226791370
Pubmed

Selection of mutant µplasmin for amyloid-β cleavage in vivo.

PLG LPA

9.28e-07234232694536
Pubmed

Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

PLG LPA

9.28e-0723427525077
Pubmed

Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

PLG LPA

9.28e-0723426216475
Pubmed

Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models.

PLG LPA

9.28e-07234216052596
Pubmed

Functional corpora lutea are formed in matrix metalloproteinase inhibitor-treated plasminogen-deficient mice.

PLG LPA

9.28e-07234217122079
Pubmed

The generation and characterization of mice expressing a plasmin-inactivating active site mutation.

PLG LPA

9.28e-07234220653841
Pubmed

Influence of plasminogen deficiency on the contribution of polymorphonuclear leucocytes to fibrin/ogenolysis: studies in plasminogen knock-out mice.

PLG LPA

9.28e-07234212428098
Pubmed

Tissue-type plasminogen activator is a neuroprotectant in the mouse hippocampus.

PLG LPA

9.28e-07234220440070
Pubmed

Role of plasminogen in propagation of scrapie.

PLG LPA

9.28e-07234216103174
Pubmed

Plasminogen deficiency causes reduced corticospinal axonal plasticity and functional recovery after stroke in mice.

PLG LPA

9.28e-07234224732409
Pubmed

Differential expression of oxidized/native lipoprotein(a) and plasminogen in human carotid and cerebral artery plaques.

PLG LPA

9.28e-07234221300353
Pubmed

A central role for plasminogen in the inflammatory response to biomaterials.

PLG LPA

9.28e-07234215456492
Pubmed

Plasminogen promotes macrophage phagocytosis in mice.

PLG LPA

9.28e-07234224876560
Pubmed

Plasminogen is a joint-specific positive or negative determinant of arthritis pathogenesis in mice.

PLG LPA

9.28e-07234224574269
Pubmed

Spontaneous development of otitis media in plasminogen-deficient mice.

PLG LPA

9.28e-07234216956791
Pubmed

Staphylococcus aureus manganese transport protein C (MntC) is an extracellular matrix- and plasminogen-binding protein.

PLG LPA

9.28e-07234225409527
Pubmed

Beta-amyloid (Abeta) causes detachment of N1E-115 neuroblastoma cells by acting as a scaffold for cell-associated plasminogen activation.

PLG LPA

9.28e-07234215737740
Pubmed

Selective behaviors altered in plasminogen-deficient mice are reconstituted with intracerebroventricular injection of plasminogen.

PLG LPA

9.28e-07234211306011
Pubmed

The mouse plasminogen locus maps to the recombination breakpoints of the tLub2 and TtOrl partial t haplotypes but is not at the tw73 locus.

PLG LPA

9.28e-0723421543918
Pubmed

Localization of regulatory elements mediating constitutive and cytokine-stimulated plasminogen gene expression.

PLG LPA

9.28e-07234212149246
Pubmed

Restoration of thrombolytic potential in plasminogen-deficient mice by bolus administration of plasminogen.

PLG LPA

9.28e-0723428704243
Pubmed

Plasminogen deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis.

PLG LPA

9.28e-07234222056679
Pubmed

Plasmin(ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals.

PLG LPA

9.28e-07234217267741
Pubmed

Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis.

PLG LPA

9.28e-07234218311818
Pubmed

Localization of plasminogen in mouse hippocampus, cerebral cortex, and hypothalamus.

PLG LPA

9.28e-07234221190118
Pubmed

The lack of binding of VEK-30, an internal peptide from the group A streptococcal M-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain.

PLG LPA

9.28e-07234218039665
Pubmed

Reduced metastasis of Polyoma virus middle T antigen-induced mammary cancer in plasminogen-deficient mice.

PLG LPA

9.28e-0723429671388
Pubmed

A physiological function for apolipoprotein(a): a natural regulator of the inflammatory response.

PLG LPA

9.28e-07234218997104
Pubmed

Growth and behavioral development in plasminogen gene-targeted mice.

PLG LPA

9.28e-07234210885855
Pubmed

Plasmin promotes foam cell formation by increasing macrophage catabolism of aggregated low-density lipoprotein.

PLG LPA

9.28e-07234223702659
Pubmed

Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen on the surface of vascular endothelial and smooth muscle cells.

PLG LPA

9.28e-07234229990619
Pubmed

Cellular density regulation of plasminogen gene expression in mouse hepatocytes.

PLG LPA

9.28e-07234212559391
Pubmed

Reduction of experimental diabetic vascular leakage by delivery of angiostatin with a recombinant adeno-associated virus vector.

PLG LPA

9.28e-07234217293777
Pubmed

Physiologic variations in blood plasminogen levels affect outcomes after acute cerebral thromboembolism in mice: a pathophysiologic role for microvascular thrombosis.

PLG LPA

9.28e-07234227319402
Pubmed

Plasminogen is a critical host pathogenicity factor for group A streptococcal infection.

PLG LPA

9.28e-07234215333838
Pubmed

Apo(a) promotes thrombosis in a vascular injury model by a mechanism independent of plasminogen.

PLG LPA

9.28e-07234216150044
Pubmed

Plasminogen has a broad extrahepatic distribution.

PLG LPA

9.28e-07234211916082
Pubmed

Plasminogen plays a crucial role in bone repair.

PLG LPA

9.28e-07234223456978
Pubmed

Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction.

PLG LPA

9.28e-07234210854210
Pubmed

Unaltered prion protein cleavage in plasminogen-deficient mice.

PLG LPA

9.28e-07234216543819
Pubmed

Essential role of DNA-PKcs and plasminogen for the development of doxorubicin-induced glomerular injury in mice.

PLG LPA

9.28e-07234234423816
Pubmed

Delayed invasion of the kidney and brain by Borrelia crocidurae in plasminogen-deficient mice.

PLG LPA

9.28e-07234211500461
Pubmed

Gender affects skin wound healing in plasminogen deficient mice.

PLG LPA

9.28e-07234223527289
Pubmed

Dengue virus-induced autoantibodies bind to plasminogen and enhance its activation.

PLG LPA

9.28e-07234222079981
Pubmed

Growth of human squamous cell carcinoma xenografts in mice is inhibited by local angiostatin gene therapy.

PLG LPA

9.28e-07234212167431
Pubmed

Impaired wound healing in mice with a disrupted plasminogen gene.

PLG LPA

9.28e-0723428612226
Pubmed

Role of plasminogen activation in neuronal organization and survival.

PLG LPA

9.28e-07234219683575
Pubmed

Plasminogen deficiency differentially affects recruitment of inflammatory cell populations in mice.

PLG LPA

9.28e-0723429490683
Pubmed

Ovulation in plasminogen-deficient mice.

PLG LPA

9.28e-07234210537128
Pubmed

Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.

PLG LPA

9.28e-07234223555246
Pubmed

Kringle 5 of human plasminogen suppresses hepatocellular carcinoma growth both in grafted and xenografted mice by anti-angiogenic activity.

PLG LPA

9.28e-07234216481742
Pubmed

Apolipoprotein(a) inhibits the conversion of Glu-plasminogen to Lys-plasminogen: a novel mechanism for lipoprotein(a)-mediated inhibition of plasminogen activation.

PLG LPA

9.28e-07234218983515
Pubmed

Binding of plasminogen to hepatocytes isolated from injured mouse liver and nonparenchymal-cell-dependent proliferation of hepatocytes.

PLG LPA

9.28e-07234218685433
Pubmed

Plasminogen mediates communication between the peripheral and central immune systems during systemic immune challenge with lipopolysaccharide.

PLG LPA

9.28e-07234231462325
Pubmed

Plasminogen Regulates Fracture Repair by Promoting the Functions of Periosteal Mesenchymal Progenitors.

PLG LPA

9.28e-07234234378815
Pubmed

Plasmin generation plays different roles in the formation and removal of arterial and venous thrombus in mice.

PLG LPA

9.28e-07234211848464
Pubmed

Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.

PLG LPA

9.28e-0723427586361
Pubmed

Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

PLG LPA

9.28e-0723429242524
Pubmed

Histone H3 lysine 36 methyltransferase Hypb/Setd2 is required for embryonic vascular remodeling.

PLG LPA LAMA1

9.62e-072034320133625
Pubmed

Endogenous tissue-type plasminogen activator is protective during Escherichia coli-induced abdominal sepsis in mice.

PLG LPA

2.78e-06334216818777
Pubmed

Skin wound healing in MMP2-deficient and MMP2 / plasminogen double-deficient mice.

PLG LPA

2.78e-06334220163454
Pubmed

Membrane-anchored uPAR regulates the proliferation, marrow pool size, engraftment, and mobilization of mouse hematopoietic stem/progenitor cells.

PLG LPA

2.78e-06334219273908
Pubmed

Ligneous conjunctivitis in plasminogen-deficient mice.

PLG LPA

2.78e-0633429473227
Pubmed

Protective role of thrombin activatable fibrinolysis inhibitor in obstructive nephropathy-associated tubulointerstitial fibrosis.

PLG LPA

2.78e-06334217988229
Pubmed

Genetic background determines response to hemostasis and thrombosis.

PLG LPA

2.78e-06334217022820
Pubmed

Plasminogen binds to disease-associated prion protein of multiple species.

PLG LPA

2.78e-06334211438139
Pubmed

Lactational competence and involution of the mouse mammary gland require plasminogen.

PLG LPA

2.78e-06334211003846
Pubmed

Plasminogen regulates pro-opiomelanocortin processing.

PLG LPA

2.78e-06334215099286
Pubmed

Pneumococcal phosphoglycerate kinase interacts with plasminogen and its tissue activator.

PLG LPA

2.78e-06334224196407
Pubmed

Plasmin deficiency does not alter endogenous murine amyloid beta levels in mice.

PLG LPA

2.78e-06334215364412
Pubmed

Plasmin and plasminogen induce macrophage reprogramming and regulate key steps of inflammation resolution via annexin A1.

PLG LPA

2.78e-06334228320709
Pubmed

Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice.

PLG LPA

2.78e-06334217722076
Pubmed

Regulation of macrophage migration by a novel plasminogen receptor Plg-R KT.

PLG LPA

2.78e-06334221940822
Pubmed

Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification.

PLG LPA

2.78e-06334226214526
Pubmed

Plasminogen directs the pleiotropic effects of uPA in liver injury and repair.

PLG LPA

2.78e-06334212431907
InteractionFBN2 interactions

NTN5 ADAMTSL1 TRIM68 NOTCH2

3.76e-0665334int:FBN2
InteractionMEP1A interactions

MEP1A PLG LAMA1

7.91e-0624333int:MEP1A
CytobandEnsembl 112 genes in cytogenetic band chr6q26

PLG LPA

6.35e-0516342chr6q26
Cytoband6q26

PLG LPA

8.08e-05183426q26
Cytoband22q13.33

SBF1 PLXNB2

3.68e-043834222q13.33
Cytoband11p15.4

DNHD1 TRIM68

9.67e-0320034211p15.4
GeneFamilyCyclins|Mediator complex

MED23 MED13

7.98e-04332321061
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRIT2 ADAMTSL1 ROR1

1.08e-03161233593
CoexpressionNABA_MATRISOME

MEP1A NTN5 ADAMTSL1 CLEC9A PLG SEMA5B PLXNB2 EMILIN1 LPA LAMA1

3.82e-0710083410MM17056
CoexpressionNABA_MATRISOME

MEP1A NTN5 ADAMTSL1 CLEC9A PLG SEMA5B PLXNB2 EMILIN1 LPA LAMA1

4.50e-0710263410M5889
CoexpressionRANKIN_ANGIOGENIC_TARGETS_OF_VHL_HIF2A_UP

PLG LPA

2.44e-056342MM555
CoexpressionNABA_MATRISOME_ASSOCIATED

MEP1A ADAMTSL1 CLEC9A PLG SEMA5B PLXNB2 LPA

3.78e-05738347MM17058
CoexpressionNABA_MATRISOME_ASSOCIATED

MEP1A ADAMTSL1 CLEC9A PLG SEMA5B PLXNB2 LPA

4.22e-05751347M5885
CoexpressionMIKKELSEN_IPS_LCP_WITH_H3K4ME3

EXOC3L1 ADAMTSL1 EMILIN1 ARAP1

7.61e-05175344M1975
CoexpressionMIKKELSEN_IPS_LCP_WITH_H3K4ME3

EXOC3L1 ADAMTSL1 EMILIN1 ARAP1

8.31e-05179344MM845
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_TIP|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

EMILIN1 NOTCH2 ROR1 LAMA1

1.14e-05184344235890e8b424f4386b6ea52d173d20a00898df73
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Interneuron|GW19 / Sample Type, Dataset, Time_group, and Cell type.

CUBN THSD7A CNTNAP1

1.07e-04121343b2d571f571133c281d72584fe925cebbd2317829
ToppCell(03)_Secretory-(1)_24hpi|(03)_Secretory / shred by cell type and Timepoint

MEP1A POLE CNTNAP1

1.48e-041353436e473296dfe1ff7a63d701e56920c0a1b043ddc6
ToppCellprimary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EMILIN1 ROR1 LAMA1

1.71e-04142343f4e4cde228149d5a536fbf0517ed71d81e296faf
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1|Thalamus / BrainAtlas - Mouse McCarroll V32

EMILIN1 ROR1 LAMA1

2.14e-04153343e9c6fb5c41adb6595c66c3a917fe455348279e54
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_1|Thalamus / BrainAtlas - Mouse McCarroll V32

EMILIN1 ROR1 LAMA1

2.14e-04153343b8b5ff7d2feea3e3a352fb5530e49f639fe1ff88
ToppCellThalamus-Endothelial-ENDOTHELIAL_TIP|Thalamus / BrainAtlas - Mouse McCarroll V32

EMILIN1 ROR1 LAMA1

2.14e-041533432513edfae62a44e51d3556675a096723194c966c
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Spp1_Col15a1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EMILIN1 ROR1 LAMA1

2.39e-0415934334c90711c5857cf6ada7b3acff99f1d48c7caf29
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CUBN CSMD1 UNC13A

2.76e-041673433edb0570e583bb527165bcd8a4c25a042054043b
ToppCell3'-GW_trimst-2-SmallIntestine-Epithelial-Tuft-related|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A PLG CSMD1

2.76e-041673437cb5b52aaa5b595fe2e97d9e175294ea8d63b165
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NTN5 SEMA5B ROR1

2.81e-041683433fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCellfacs-Heart-LV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

THSD7A EMILIN1 ROR1

2.86e-04169343849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCelldroplet-Kidney-nan-3m-Epithelial-brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MEP1A CUBN MAMDC4

2.91e-04170343dd48fd3c5c67eb71183981f42975a538f12077c3
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EMILIN1 NOTCH2 LAMA1

2.96e-041713432e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLEC9A SBF1 ROR1

2.96e-041713431018d7bd378ce20bee56a77d5851b3538c55098c
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_3|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CSMD1 SEMA5B NOTCH2

2.96e-041713434ede831aed364cb5271f49a8b09bb6d0452f9b35
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C_(NP)-Glut_NP_L5/6_FEZF2-Exc_L5-6_FEZF2_MYBPHL|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADAMTSL1 SEMA5B ROR1

2.96e-041713430417fa805ca0acb7e9f6a30bc7b6bdbaba77844d
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLEC9A SBF1 ROR1

2.96e-04171343173bb5318fdbaef6e695b6f9e3e0ff4a5432a1a4
ToppCell3'-Distal_airway-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CLEC9A SBF1 ROR1

2.96e-041713436bda333bb751d7835a04f21ac959eea79f2516aa
ToppCellfrontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

EMILIN1 NOTCH2 LAMA1

2.96e-04171343e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCellThalamus-Neuronal-Excitatory|Thalamus / BrainAtlas - Mouse McCarroll V32

PPP3CB THSD7A UNC13A

3.22e-04176343d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCellprimary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Penk_Fst|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NTN5 SEMA5B ROR1

3.22e-04176343a1b9f8f199a028b3fa85de43fe96bc29f387bfd8
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

3.22e-041763431595dbeee336a81e581325d63208ec6262664ee9
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

3.27e-041773432f81b26be89cc2fd8eafadaf7eae3c6ad6521462
ToppCellPosterior_cortex-Endothelial-ENDOTHELIAL_TIP|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

EMILIN1 NOTCH2 LAMA1

3.33e-04178343cda7695411655bd6d0ba69e5041ca7530a9dad3a
ToppCellSmart-start-Cell-Wel_seq-Neoplastic-Differentiated-like-MES-like-MES-like_hypoxia/MHC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

EXOC3L1 CUBN SEMA5B

3.44e-04180343e4add4c94f892a2d93926e5c6dac6a738319d091
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

3.50e-04181343bec917f6f56ae252639a5a76024be5df5c70a6d5
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

3.55e-04182343e1e58176f533092b6b974ca1ce8b02192a6e193d
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

3.55e-041823434a9c13932e7163fd37a3dcc4c6ca3bbea5372459
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

3.55e-0418234357bb5a2da976464ba7c4460106bd9f692008ebd9
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

3.61e-0418334385446581999cd66b171c4f69b7eb8b0bbbaa8617
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

PLG CUBN ROR1

3.67e-04184343dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

3.79e-04186343a417e1e21313a7e05951038cdef5ac672a9f727c
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

PLG LPA ROR1

3.79e-041863434d68ee3d32f7ef884faf402ef92b31b0eb4656f1
ToppCellCOVID-19-kidney-Mito-rich_PCT|kidney / Disease (COVID-19 only), tissue and cell type

PLG CUBN ROR1

3.85e-04187343738ec2611b4be6a08eedad16b57fba84e1f11fef
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

PLG CUBN ROR1

3.85e-04187343acd305475f3609800af0d7bc68d83ef41228080b
ToppCellfacs-Trachea-nan-3m-Mesenchymal-smooth_muscle_cell_of_trachea|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NTN5 CSMD1 ROR1

3.91e-04188343794fc1d9a726945c42f7eac221eed938309b47a9
ToppCellCOVID-19-Heart-EC_(POSTN)|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTSL1 CSMD1 THSD7A

3.97e-041893437346c1112e2e155dbd71b6dbc80e680fd262a691
ToppCellCOPD-Endothelial-VE_Arterial|Endothelial / Disease state, Lineage and Cell class

CSMD1 THSD7A ROR1

4.09e-04191343ef16ad1c1cd2c0c0377957398c98775b62a81754
ToppCelldroplet-Kidney-nan-18m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 CSMD1 EMILIN1

4.15e-0419234338d7a24ae205ef91ed2e0f402d8022f2a9cdb243
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 CSMD1 EMILIN1

4.15e-0419234384149a5c6c3b3c9b86aed77cf8e72d99ef099fab
ToppCelldroplet-Kidney-nan-18m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 CSMD1 EMILIN1

4.15e-0419234304d155897ed075c359933080e36a4ab2150b6e9f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PLG CUBN CSMD1

4.15e-041923433e1a4cb0d83efd502c8613d41a1692bdda5860ed
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

4.22e-0419334332eb026d4317c1499d51294d396dfd5f293f9deb
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

EXOC3L1 ADAMTSL1 THSD7A

4.22e-04193343af5108260783e69a7d67896c5bf64f862525926d
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Colonocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

4.22e-04193343930df79b0600f43617052313294be33bcf5631f0
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

THSD7A EMILIN1 ROR1

4.28e-04194343b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

4.28e-04194343fcbf9c4f3801ab1a34fcd62c752fabc97fc7bde1
ToppCell5'-Adult-SmallIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A SEMA5B NOTCH2

4.35e-04195343e87b11e3242fdbed2e7f383e6876ec375af32bd4
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic-neutrophil|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ADAMTSL1 CSMD1 LAMA1

4.35e-04195343d3755929ebbbf5e3afde44281e9056ddb614a291
ToppCelldroplet-Bladder-BLADDER-1m-Epithelial-bladder_mesenchymal_cell_(Scara5+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADAMTSL1 EMILIN1 ARAP1

4.35e-04195343d663d54a4bcc94e2c9b50ed931e2b2db4ca41373
ToppCellSmart-seq2-spleen_(Smart-seq2)-myeloid-myeloid_granulocytic|spleen_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ADAMTSL1 CSMD1 LAMA1

4.35e-0419534319853c654ac64b3ae3bc99841c6cb29c8aaba85c
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

THSD7A EMILIN1 ROR1

4.35e-041953431cdf5f296029ae424d9dba42e86a6d111e4896e6
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

THSD7A EMILIN1 ROR1

4.35e-041953430e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCellPCW_05-06-Mesenchymal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

EMILIN1 NOTCH2 ROR1

4.41e-04196343dca52c57ba35d9395cdbca8b881f12ece721b10f
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

THSD7A EMILIN1 ROR1

4.41e-041963431450cb69c5bf469e97c03bf1890f6f7c54165b8a
ToppCellfacs-Bladder-nan-3m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMILIN1 NOTCH2 ARAP1

4.41e-0419634344f5b1b474399c9316729155f2ea95a82ca66e30
ToppCellfacs-Bladder-nan-3m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EMILIN1 NOTCH2 ARAP1

4.41e-04196343c0e90d964baa2eb4fbd18a52379ccec5d3bf59a8
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG-25|World / Primary Cells by Cluster

SEMA5B NOTCH2 LAMA1

4.48e-041973439d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature3_(17)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

THSD7A EMILIN1 ROR1

4.48e-0419734331a1852911bda38543916585fda34255fd62a134
ToppCellNon-neuronal-Non-dividing-Radial_Glia-tRG|World / Primary Cells by Cluster

SEMA5B NOTCH2 LAMA1

4.48e-0419734361749ccafeb938c310cff1de5ff924a1c794325a
ToppCellfacs-Trachea-3m|Trachea / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TMX1 EMILIN1 NOTCH2

4.48e-04197343e77016d64b1cac9825fec7cfe5071f1567401187
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

4.48e-04197343a6a27e5809ee2c9b56c7e06c35e4f140f9fa13ad
ToppCellfacs-Trachea-nan-3m|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TMX1 EMILIN1 NOTCH2

4.48e-041973430353d925ee4b7aefc2c51b5fab873f465cdf9ebc
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

THSD7A EMILIN1 ROR1

4.54e-0419834317dc055e2a289496d9c5cdbf3297bdf906dc6d22
ToppCellTransverse-T_cell-Tcm|T_cell / Region, Cell class and subclass

OCRL EMILIN1 UNC13A

4.54e-0419834362990b9ff7ca20895fed07461baba6c2caaa995e
ToppCellCOVID-19-lung-Capillary_2|lung / Disease (COVID-19 only), tissue and cell type

EXOC3L1 CSMD1 THSD7A

4.61e-04199343793ce71b78a68033ef4419ed571e1dd86b40124f
ToppCellFetal_29-31_weeks|World / Lineage, Cell type, age group and donor

ADAMTSL1 EMILIN1 ROR1

4.61e-041993435b9d355795dd03a22f0961dfd143425c367a4654
ToppCellTracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTSL1 UNC13A ROR1

4.61e-04199343fbec5c034576cb1adaf05f6f97cc5525d19e0c1b
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SEMA5B ROR1 CNTNAP1

4.61e-0419934383383d9ae4f501754fd3da0215ce6f0e3c70562c
ToppCellBronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_epineurial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADAMTSL1 ROR1 CNTNAP1

4.61e-04199343a13f4b8a039304e685464cc8879659824cad5a3e
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-DC-DC3-E|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLEC9A SBF1 CNTNAP1

4.61e-041993437271dbeca9aa838b88ad44d00059263a29c0316b
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related-BEST4+_epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A PLXNB2 NOTCH2

4.61e-0419934301d101b0fd5326947a9e5dddae6c2f93ab6e0a4d
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

4.61e-04199343f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

4.61e-04199343a10768e1cddd2d38291c30d24820a94040a72211
ToppCell3'-Adult-LargeIntestine-Epithelial-Tuft-related|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A PLXNB2 NOTCH2

4.61e-041993436d439c0c5e6b72fcb8d4dc72e7445eb6a01fe095
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

MEP1A CUBN MAMDC4

4.68e-0420034373bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm|1m / Sample Type, Dataset, Time_group, and Cell type.

EXOC3L1 MED23 CNTNAP1

4.68e-04200343c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
DrugAminocaproic Acid

PLG LPA

5.74e-063322DB00513
Diseasechronic kidney disease, APOL1 risk genotype carrier status

PLG LPA

1.29e-055342EFO_0003884, EFO_0009324
Diseaseplasma plasminogen measurement

PLG LPA

1.29e-055342EFO_0006309
Diseaseangiostatin measurement

PLG LPA

1.93e-056342EFO_0008024
Diseaselipoprotein A measurement, apolipoprotein A 1 measurement

PLG LPA

2.70e-057342EFO_0004614, EFO_0006925
Diseasealbuminuria

CUBN CSMD1 LPA

1.74e-0494343EFO_0004285
DiseaseDeep Vein Thrombosis

PLG LPA

2.67e-0421342C0149871
DiseaseVenous Thrombosis

PLG LPA

2.67e-0421342C0042487
Diseasearginine measurement

CSMD1 MED23

3.21e-0423342EFO_0020990
Diseaseresponse to angiotensin-converting enzyme inhibitor, response to angiotensin receptor blocker, angioedema

ADAMTSL1 THSD7A

4.12e-0426342EFO_0005325, EFO_0005532, EFO_0010735
Diseaseblood manganese measurement

OCRL CSMD1

4.44e-0427342EFO_0007581
Diseasecolorectal cancer (implicated_via_orthology)

POLE NOTCH2

5.49e-0430342DOID:9256 (implicated_via_orthology)
Diseaseprostate cancer (implicated_via_orthology)

MEP1A POLE

6.65e-0433342DOID:10283 (implicated_via_orthology)
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

PLG LPA

7.06e-0434342EFO_0008317, EFO_0008596, EFO_0020944
Diseasechylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

PLG LPA

7.06e-0434342EFO_0008317, EFO_0008596, EFO_0020947
Diseasecholesteryl esters to total lipids in medium LDL percentage

PLG LPA

8.37e-0437342EFO_0022252
Diseaselipoprotein-associated phospholipase A(2) measurement

PLG LPA

9.78e-0440342EFO_0004746
Diseasecholesteryl esters to total lipids in small LDL percentage

PLG LPA

1.08e-0342342EFO_0022255
DiseaseCharcot-Marie-Tooth disease

SBF1 CNTNAP1

1.08e-0342342cv:C0007959
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

PLG LPA

1.08e-0342342EFO_0008317, EFO_0008596, EFO_0020945
Diseasefree cholesterol to total lipids in very small VLDL percentage

PLG LPA

1.13e-0343342EFO_0022290

Protein segments in the cluster

PeptideGeneStartEntry
PLPVPSNQCCNWNYF

UNC13A

166

Q9UPW8
AVRPGPCWAPNYCSF

MAMDC4

801

Q6UXC1
PCCPPQYNVVQLWAH

EXOC3L1

296

Q86VI1
PALYCNCDADQPQWR

CNTNAP1

726

P78357
CVQLNNRFFWQPDPP

CSMD1

1431

Q96PZ7
INRNWNYPFPRCDAP

CSMD1

2131

Q96PZ7
PCPACPFVQAQWSRQ

DNHD1

161

Q96M86
VDGVNTYNCRCPPQW

NOTCH2

276

Q04721
TYNCRCPPQWTGQFC

NOTCH2

281

Q04721
CSSPLPCWDYINNQC

NOTCH2

1466

Q04721
FLNWPAYQKCRQPDC

LRIT2

171

A6NDA9
QACNRFNCPPAWYPA

ADAMTSL1

721

Q8N6G6
FNCPPAWYPAQWQPC

ADAMTSL1

726

Q8N6G6
DQVYRGQPCSCWPRP

PLXNB2

1496

O15031
PFPNCDWRFNEFPNP

MED23

1086

Q9ULK4
VLPQWLCSNCQAPYD

POLE

2181

Q07864
VWPCYDSCPRAQPDA

SBF1

1636

O95248
SPNFPNNYPNNWECI

CUBN

1061

O60494
KNYCRNPDPVAAPWC

LPA

986

P08519
KYQPCAWGQPQCPQS

EMILIN1

81

Q9Y6C2
RQFNCSPHPYWLPNF

PPP3CB

341

P16298
CPCDKYNAQPVGNWS

THSD7A

956

Q9UPZ6
CHYCQPGFWRDPSQP

NTN5

251

Q8WTR8
NLNRYCQEHWPFQPC

TEX48

101

A0A1B0GUV7
CNRCCPGYHQQPWRP

LAMA1

301

P25391
WPQYFRDPCDPNPCQ

MEP1A

666

Q16819
FWSACPQAQYQCPLF

MED13

2081

Q9UHV7
YCRNPDNDPQGPWCY

PLG

151

P00747
WLNCDPNPPDIYCIG

OCRL

261

Q01968
PNRFCADCGAPQPDW

ARAP1

546

Q96P48
SPCPNNWIQNRESCY

CLEC9A

111

Q6UXN8
TCQPPQFQLLWLCPY

NDUFV1-DT

191

Q8NBR9
YCRNPGNQKEAPWCF

ROR1

361

Q01973
QNWGYTCPLCRAPVQ

TRIM68

51

Q6AZZ1
RFCNENTPCPVPIFW

SEMA5B

711

Q9P283
WWRCNGPCQHRPPYY

SPRTN

166

Q9H040
NARPDNWFCYPCIPN

ZMYND11

266

Q15326
FYAPWCPACQNLQPE

TMX1

51

Q9H3N1