Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	CHDCT2	CHD5 CHD4	2.64e-05	3	56	2	PF08074
Domain	CHDNT	CHD5 CHD4	2.64e-05	3	56	2	PF08073
Domain	DUF1086	CHD5 CHD4	2.64e-05	3	56	2	IPR009462
Domain	DUF1087	CHD5 CHD4	2.64e-05	3	56	2	IPR009463
Domain	CHD_N	CHD5 CHD4	2.64e-05	3	56	2	IPR012958
Domain	CHD_C2	CHD5 CHD4	2.64e-05	3	56	2	IPR012957
Domain	DUF1087	CHD5 CHD4	2.64e-05	3	56	2	PF06465
Domain	DUF1086	CHD5 CHD4	2.64e-05	3	56	2	PF06461
Domain	DUF1087	CHD5 CHD4	2.64e-05	3	56	2	SM01147
Domain	DUF1086	CHD5 CHD4	2.64e-05	3	56	2	SM01146
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH7	7.85e-04	14	56	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH7	7.85e-04	14	56	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH7	7.85e-04	14	56	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH7	7.85e-04	14	56	2	PF08393
Domain	IMPORTIN_B_NT	IPO9 XPO6	7.85e-04	14	56	2	PS50166
Domain	MT	DNAH3 DNAH7	7.85e-04	14	56	2	PF12777
Domain	AAA_8	DNAH3 DNAH7	7.85e-04	14	56	2	PF12780
Domain	CNH	TNIK MAP4K3	7.85e-04	14	56	2	SM00036
Domain	DHC_fam	DNAH3 DNAH7	9.04e-04	15	56	2	IPR026983
Domain	IBN_N	IPO9 XPO6	9.04e-04	15	56	2	PF03810
Domain	CNH	TNIK MAP4K3	9.04e-04	15	56	2	PF00780
Domain	Dynein_heavy_dom	DNAH3 DNAH7	9.04e-04	15	56	2	IPR004273
Domain	CNH	TNIK MAP4K3	9.04e-04	15	56	2	PS50219
Domain	CNH_dom	TNIK MAP4K3	9.04e-04	15	56	2	IPR001180
Domain	Dynein_heavy	DNAH3 DNAH7	9.04e-04	15	56	2	PF03028
Domain	HMG_box_dom	SOX9 CHD5 CHD4	9.78e-04	65	56	3	IPR009071
Domain	IBN_N	IPO9 XPO6	1.03e-03	16	56	2	SM00913
Domain	Importin-beta_N	IPO9 XPO6	1.17e-03	17	56	2	IPR001494
Domain	WD40_repeat_CS	BOP1 WDFY3 HERC1 PHIP	1.48e-03	164	56	4	IPR019775
Domain	Chromo_domain	CHD5 CHD4	2.34e-03	24	56	2	IPR023780
Domain	Chromo	CHD5 CHD4	2.74e-03	26	56	2	PF00385
Domain	CHROMO_1	CHD5 CHD4	3.17e-03	28	56	2	PS00598
Domain	CHROMO_2	CHD5 CHD4	3.17e-03	28	56	2	PS50013
Domain	ARM-type_fold	IPO9 XPO6 MROH2A ZNFX1 WDFY3	3.42e-03	339	56	5	IPR016024
Domain	SNF2_N	CHD5 CHD4	4.13e-03	32	56	2	IPR000330
Domain	Chromodomain-like	CHD5 CHD4	4.13e-03	32	56	2	IPR016197
Domain	SNF2_N	CHD5 CHD4	4.13e-03	32	56	2	PF00176
Domain	Chromo/shadow_dom	CHD5 CHD4	4.39e-03	33	56	2	IPR000953
Domain	CHROMO	CHD5 CHD4	4.39e-03	33	56	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD5 CHD4	4.93e-03	35	56	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD5 CHD4	5.79e-03	38	56	2	PS00690
Domain	WD40	BOP1 WDFY3 HERC1 PHIP	7.55e-03	259	56	4	PF00400
Domain	WD40	BOP1 WDFY3 HERC1 PHIP	8.49e-03	268	56	4	SM00320
Domain	ARM-like	IPO9 XPO6 MROH2A WDFY3	8.71e-03	270	56	4	IPR011989
Domain	WD40_repeat	BOP1 WDFY3 HERC1 PHIP	8.93e-03	272	56	4	IPR001680
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 SOX9 ZNF99	5.24e-07	10	58	3	18588511
Pubmed	Chd4 and associated proteins function as corepressors of Sox9 expression during BMP-2-induced chondrogenesis.	SOX9 CHD4	2.73e-06	2	58	2	23519980
Pubmed	NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression.	CHD4 SUZ12	8.19e-06	3	58	2	22139358
Pubmed	SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation.	SENP2 NDN CIDEA	9.86e-06	25	58	3	31433978
Pubmed	Active maintenance of nuclear actin by importin 9 supports transcription.	IPO9 XPO6	1.64e-05	4	58	2	22323606
Pubmed	E6-AP/UBE3A protein acts as a ubiquitin ligase toward SOX9 protein.	SOX9 HERC1	1.64e-05	4	58	2	24155239
Pubmed	The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.	CHD4 SUZ12	2.72e-05	5	58	2	23624931
Pubmed	A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.	CHD5 CHD4 PHIP	3.02e-05	36	58	3	29089422
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	TNIK XPO6 CHD5 SENP2 WDFY3	3.76e-05	225	58	5	12168954
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TYK2 XPO6 AHNAK CHD5 SCN5A MTMR8 SENP2 WDFY3 HERC1	8.39e-05	1105	58	9	35748872
Pubmed	Depression compromises antiviral innate immunity via the AVP-AHI1-Tyk2 axis.	TYK2 BOP1	1.22e-04	10	58	2	35821088
Pubmed	A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.	TNIK ROBO1	1.22e-04	10	58	2	19023125
Pubmed	Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors.	SOX9 CHD4 SUZ12	1.48e-04	61	58	3	19796622
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF99	1.49e-04	11	58	2	15469996
Pubmed	De novo genic mutations among a Chinese autism spectrum disorder cohort.	WDFY3 YTHDC1	1.78e-04	12	58	2	27824329
Pubmed	Rescuing the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance.	SOX9 UTY	1.78e-04	12	58	2	28949961
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF99	2.11e-04	13	58	2	19850934
Pubmed	ZBTB2 protein is a new partner of the Nucleosome Remodeling and Deacetylase (NuRD) complex.	CHD5 CHD4 SUZ12 YTHDC1 PHIP	2.26e-04	330	58	5	33301849
Pubmed	Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brain.	ROBO1 WDFY3	2.46e-04	14	58	2	27648578
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH3 DNAH7	2.46e-04	14	58	2	9373155
Pubmed	Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.	CHD4 DNAH7 PHIP	2.73e-04	75	58	3	25593309
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF99	2.83e-04	15	58	2	15885501
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD5 CHD4	2.83e-04	15	58	2	35695185
Pubmed	The chromatin remodeling factor CHD5 is a transcriptional repressor of WEE1.	CHD5 CHD4	2.83e-04	15	58	2	25247294
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	IPO9 ACACB AHNAK BOP1 CHD4 RP9 YTHDC1 PRPF39 PHIP	3.13e-04	1318	58	9	30463901
Pubmed	Ikaros SUMOylation: switching out of repression.	SENP2 CHD4	3.66e-04	17	58	2	15767674
Pubmed	A Functional Switch of NuRD Chromatin Remodeling Complex Subunits Regulates Mouse Cortical Development.	CHD5 CHD4	3.66e-04	17	58	2	27806305
Pubmed	TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation.	CHD4 SUZ12	4.11e-04	18	58	2	28068325
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	TYK2 CHD5 SCN5A CHD4 SUZ12 WDFY3 PHIP NUFIP1	5.06e-04	1116	58	8	31753913
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	SOX9 CHD5 BOP1 CHD4 SUZ12 PHIP	5.21e-04	608	58	6	36089195
Pubmed	Isolation of differentially expressed genes from wild-type and Twist mutant mouse limb buds.	SOX9 CHD4	5.62e-04	21	58	2	12124942
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TNIK SENP2 SUZ12 EPG5 PDZD2	5.90e-04	407	58	5	12693553
Pubmed	Terminal differentiation of cortical neurons rapidly remodels RanGAP-mediated nuclear transport system.	SENP2 NDN	6.18e-04	22	58	2	27717094
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	ACACB AHNAK HERC1 UTY	6.37e-04	234	58	4	36243803
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	IPO9 ACACB ZNFX1 WDFY3 DNAH7 UTY	6.71e-04	638	58	6	31182584
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	TNIK ACACB MTMR8 HERC1 DNAH7	6.79e-04	420	58	5	28065597
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	WDFY3 UTY	7.37e-04	24	58	2	17452356
Pubmed	Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex.	AHNAK SENP2 CHD4	7.52e-04	106	58	3	19394292
Pubmed	Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.	SLC9A9 EPG5	9.34e-04	27	58	2	18649358
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	AHNAK CHD5 BOP1 CHD4 RP9 MRPL3 YTHDC1	9.87e-04	949	58	7	36574265
Pubmed	Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.	TSHZ2 PDZD2	1.00e-03	28	58	2	24322204
Pubmed	Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation.	MRPL44 MRPL3	1.00e-03	28	58	2	32376682
Pubmed	The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap.	SOX9 ROBO1	1.08e-03	29	58	2	25336744
Pubmed	Anteroposterior Limb Skeletal Patterning Requires the Bifunctional Action of SWI/SNF Chromatin Remodeling Complex in Hedgehog Pathway.	SOX9 SUZ12	1.08e-03	29	58	2	26959361
Pubmed	Gene expression and characterization of clonally derived murine embryonic brown and brite adipocytes.	ACACB CIDEA	1.08e-03	29	58	2	38972757
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF99	1.08e-03	29	58	2	14563677
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	AHNAK SENP2 SUZ12 YTHDC1 PHIP	1.11e-03	469	58	5	27634302
Pubmed	Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate.	SOX9 ROBO1	1.40e-03	33	58	2	18480165
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	ACACB SCN5A	1.48e-03	34	58	2	26378152
Pubmed	Robo signalling controls pancreatic progenitor identity by regulating Tead transcription factors.	SOX9 ROBO1	1.48e-03	34	58	2	30504829
Pubmed	Inceptor counteracts insulin signalling in β-cells to control glycaemia.	SOX9 ACACB	1.48e-03	34	58	2	33505018
Pubmed	Mettl14-mediated m6A modification ensures the cell-cycle progression of late-born retinal progenitor cells.	SOX9 YTHDC1	1.57e-03	35	58	2	37269288
Pubmed	Identification of the BRD1 interaction network and its impact on mental disorder risk.	CHD5 CHD4	1.57e-03	35	58	2	27142060
Pubmed	Axon guidance genes control hepatic artery development.	SOX9 ROBO1	1.66e-03	36	58	2	37497580
Pubmed	An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.	TYK2 XPO6 RALBP1 MTMR8 YTHDC1	1.66e-03	514	58	5	29892012
Cytoband	19p12	ZNF729 ZNF723 ZNF99	2.08e-04	90	58	3	19p12
Cytoband	Ensembl 112 genes in cytogenetic band chr19p12	ZNF729 ZNF723 ZNF99	5.08e-04	122	58	3	chr19p12
GeneFamily	PHD finger proteins\|NuRD complex	CHD5 CHD4	3.11e-04	12	40	2	1305
GeneFamily	Dyneins, axonemal	DNAH3 DNAH7	6.36e-04	17	40	2	536
GeneFamily	WD repeat domain containing	BOP1 WDFY3 HERC1 PHIP	2.61e-03	262	40	4	362
Disease	homocitrulline measurement	SLC7A9 TNIK	7.12e-05	7	55	2	EFO_0021018
Disease	apolipoprotein A 1 measurement	GPR180 ACACB TSHZ2 XPO6 HERC1 RNF145 PHIP	9.65e-04	848	55	7	EFO_0004614
Disease	Autistic Disorder	SLC9A9 DAO ROBO1 CHD4	1.43e-03	261	55	4	C0004352

Protein segments in the cluster

Peptide	Gene	Start	Entry
IAAQMMDIWVPIKIG	ACSBG2	276	Q5FVE4
VSRMVHAIKMGWIQP	BOP1	256	Q14137
RKLPWKDLHPDQMLM	EPG5	2056	Q9HCE0
GIKPEWMMIHRILNH	CHD5	586	Q8TDI0
NKPKWAMNMAILLSH	ADORA2B	266	P29275
IKMQEGVKMALHLPW	CDCP1	186	Q9H5V8
VEVQGPDWHLKMPKM	AHNAK	866	Q09666
DVEMQGPDWNLKMPK	AHNAK	986	Q09666
VHGPDWHLKMPKVKM	AHNAK	1501	Q09666
VQGPDWHLKMPKIKM	AHNAK	3141	Q09666
VHGPDWHLKMPKVKM	AHNAK	4051	Q09666
VHGPDWHLKMPKVKM	AHNAK	4771	Q09666
YWIHKGMPSEKVVMG	CHI3L2	251	Q15782
VVLKQVMKPLRWSNM	RALBP1	371	Q15311
TLMGEWKMGPVLCHL	NPY2R	111	P49146
QIMKVDAPWMKHFIL	DAO	201	P14920
LKEWVQKLMMTLRHP	ACACB	1021	O00763
PGKMHAKIWLMKTSL	C20orf96	91	Q9NUD7
WVEPMQKFMLIKHID	MAP4K3	701	Q8IVH8
MAWMLLLILIMVHPG	NCR3	1	O14931
LMILIEKEWISMGHK	MTMR8	366	Q96EF0
HWISKQGQKLEMMLE	KIAA2026	176	Q5HYC2
MATMIPPVKLKWLEH	HERC1	1	Q15751
KPLVGLMHFDAWNIM	PDZD2	2806	O15018
DNKMKLFLHWINPEM	FAM205C	256	A6NFA0
SLWQAIKKGGPMHMI	GPR180	191	Q86V85
HLPKKPMVHMLWAAF	PRPF39	416	Q86UA1
NSMLVGKVPAMWAAK	DNAH3	3916	Q8TD57
WDLMVGLTPKTIMHL	DNM1P34	51	Q6PK57
WAQKISKPITMHLQM	SLC7A9	461	P82251
SILNVKIPEMWMGKS	DNAH7	3826	Q8WXX0
KHMVSSMQQILPIVW	IPO9	281	Q96P70
GLSMVDWHLIKEMKP	COX15	96	Q7KZN9
GIKPEWMMIHRILNH	CHD4	616	Q14839
KKVLDNMHHVLLVWM	CYP4F22	86	Q6NT55
KMWKLVHTTPLPEEM	MROH2A	1271	A6NES4
KGEVKKAWIPLMLHS	MROH2A	1511	A6NES4
MMPLWTKDGQKHVVT	MRPL3	106	P09001
QMPLFRKKMVWEILH	SENP2	571	Q9HC62
PMVHLSWNMARNIKV	UTY	1216	O14607
KELFEMWKIINPMGL	MRPL44	226	Q9H9J2
GLWMPLGKEVKVMQC	RP9	91	Q8TA86
LGRKQKIPWNFQHMM	SLC9A9	421	Q8IVB4
IKMVHLLVLSGAWGM	TMEM205	11	Q6UW68
PLWMSIKQGVKLVVM	SCN5A	701	Q14524
MIHPLCNMTLKGVVW	SIAE	261	Q9HAT2
NKPHVKRPMNAFMVW	SOX9	101	P48436
NTHFMILEKGQKWMP	CIDEA	96	O60543
KMVVSMTLGLHPWIA	CNDP1	406	Q96KN2
LKQGKEPWNMKRHEM	ZNF99	56	A8MXY4
KKNPPGMDDQLWLVM	TNIK	91	Q9UKE5
GQWHHLVLVMSKGML	WDFY3	1191	Q8IZQ1
HWRNMHAPGMKKIKL	NUFIP1	216	Q9UHK0
QPWHKMELREQELMK	PHIP	991	Q8WWQ0
KEVMKLWNLHVMKHG	SUZ12	611	Q15022
LEQGKEPWNMKRHKM	ZNF723	56	P0DPD5
PMHDASMWHLKKNGI	THNSL1	136	Q8IYQ7
MKWKHVPFLVMISLL	ROBO1	1	Q9Y6N7
KWKVMPLVSMPTHLA	TSHZ2	581	Q9NRE2
IHWVLPAGMSAKMLG	YTHDC1	426	Q96MU7
IGNMQMLAKVPLWSK	ZNFX1	1231	Q9P2E3
LINKMWLGVPSQDKM	XPO6	71	Q96QU8
MKTKQIWLFSAHMLP	RNF145	141	Q96MT1
PMAAMGGLKVLLHWA	TYK2	21	P29597
KQGKEPWNMKRHEMV	ZNF729	66	A6NN14
KMIIWFPDMVKDVIG	NDN	116	Q99608