Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglutamate-gated calcium ion channel activity

GRIN2C GRIN2D

2.54e-048612GO:0022849
GeneOntologyMolecularFunctionNMDA glutamate receptor activity

GRIN2C GRIN2D

2.54e-048612GO:0004972
GeneOntologyMolecularFunctionzinc ion binding

ENPP3 RNF112 TET1 CXXC4 NFX1 KDM4A ADAMTS5 NSMCE2 USP20 USP33

3.39e-048916110GO:0008270
GeneOntologyMolecularFunctionRNA polymerase II transcription regulatory region sequence-specific DNA binding

ZNF711 ZNF280D ZC3H8 TET1 ZNF254 ZNF667 NFX1 ZNF510 RREB1 ZNF439 ZNF786 ZFP82 ZFX

3.85e-0414596113GO:0000977
GeneOntologyMolecularFunctionRoundabout binding

SLIT2 SLIT1

5.94e-0412612GO:0048495
GeneOntologyMolecularFunctionDNA-binding transcription factor activity, RNA polymerase II-specific

ZNF711 RLF ZNF280D ZC3H8 ZNF254 NFX1 ZNF510 RREB1 ZNF439 ZNF786 ZFP82 ZFX

1.02e-0314126112GO:0000981
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIN2C GRIN2D

1.21e-0317612GO:0004970
GeneOntologyBiologicalProcesschemorepulsion involved in embryonic olfactory bulb interneuron precursor migration

SLIT2 SLIT1

2.49e-053602GO:0021834
GeneOntologyBiologicalProcessepigenetic regulation of gene expression

RLF PHF19 BAZ1A TET1 ZNF254 FAM47E H1-9P

4.70e-05330607GO:0040029
GeneOntologyBiologicalProcessdorsal/ventral axon guidance

SLIT2 SLIT1

4.97e-054602GO:0033563
GeneOntologyBiologicalProcessembryonic olfactory bulb interneuron precursor migration

SLIT2 SLIT1

8.27e-055602GO:0021831
DomainZINC_FINGER_C2H2_2

ZNF711 RLF PRDM10 PHF20 ZNF280D RBM10 ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

1.93e-087756115PS50157
DomainZnf_C2H2-like

ZNF711 RLF PRDM10 PHF20 ZNF280D RBM10 ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

2.75e-087966115IPR015880
DomainZnf_C2H2

ZNF711 RLF PRDM10 PHF20 ZNF280D RBM10 ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

3.20e-088056115IPR007087
DomainZnF_C2H2

ZNF711 RLF PRDM10 PHF20 ZNF280D RBM10 ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

3.36e-088086115SM00355
Domainzf-C2H2

ZNF711 RLF PRDM10 PHF20 ZNF280D ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

3.68e-086936114PF00096
DomainZINC_FINGER_C2H2_1

ZNF711 RLF PRDM10 PHF20 ZNF280D ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

1.51e-077776114PS00028
Domain-

PHF20 PHF19 UBE4B BAZ1A RNF112 PHF11 PHF7 KDM4A NSMCE2 USP20 USP33

1.94e-0744961113.30.40.10
DomainZnf_RING/FYVE/PHD

PHF20 PHF19 UBE4B BAZ1A RNF112 PHF11 PHF7 KDM4A NSMCE2 USP20 USP33

2.42e-074596111IPR013083
DomainPHD

PHF20 PHF19 BAZ1A PHF11 PHF7 KDM4A

4.44e-0789616SM00249
DomainZnf_PHD

PHF20 PHF19 BAZ1A PHF11 PHF7 KDM4A

5.07e-0791616IPR001965
DomainZF_PHD_2

PHF20 PHF19 BAZ1A PHF11 PHF7 KDM4A

6.54e-0795616PS50016
DomainZF_PHD_1

PHF20 PHF19 BAZ1A PHF11 PHF7 KDM4A

6.96e-0796616PS01359
Domain-

ZNF711 RLF PRDM10 ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

1.64e-0667961123.30.160.60
DomainZnf_C2H2/integrase_DNA-bd

ZNF711 RLF PRDM10 ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

2.06e-066946112IPR013087
DomainZnf_FYVE_PHD

PHF20 PHF19 BAZ1A PHF11 PHF7 KDM4A

8.34e-06147616IPR011011
DomainZfx_Zfy_act

ZNF711 ZFX

3.14e-053612PF04704
DomainTranscrp_activ_Zfx/Zfy-dom

ZNF711 ZFX

3.14e-053612IPR006794
DomainEPHD

PHF11 PHF7 KDM4A

4.88e-0522613PS51805
DomainZinc_finger_PHD-type_CS

PHF20 PHF19 BAZ1A NFX1

6.01e-0565614IPR019786
DomainTUDOR

PHF20 PHF19 KDM4A

9.17e-0527613SM00333
DomainhEGF

SLIT2 FAT4 SLIT1

1.02e-0428613PF12661
DomainTudor

PHF20 PHF19 KDM4A

1.26e-0430613IPR002999
DomainZnf_PHD-finger

PHF20 PHF19 BAZ1A NFX1

1.29e-0479614IPR019787
DomainDUSP

USP20 USP33

1.56e-046612SM00695
DomainDUSP

USP20 USP33

1.56e-046612PF06337
DomainKRAB

ZNF254 ZNF667 ZNF510 ZNF230 ZNF439 ZNF786 ZFP82

1.61e-04358617PS50805
DomainKRAB

ZNF254 ZNF667 ZNF510 ZNF230 ZNF439 ZNF786 ZFP82

1.61e-04358617PF01352
DomainKRAB

ZNF254 ZNF667 ZNF510 ZNF230 ZNF439 ZNF786 ZFP82

1.94e-04369617SM00349
DomainKRAB

ZNF254 ZNF667 ZNF510 ZNF230 ZNF439 ZNF786 ZFP82

1.97e-04370617IPR001909
Domain-

USP20 USP33

2.18e-0476123.30.2230.10
DomainDUSP

USP20 USP33

2.18e-047612PS51283
DomainPept_C19_DUSP

USP20 USP33

2.18e-047612IPR006615
DomainLAM_G_DOMAIN

SLIT2 FAT4 SLIT1

2.58e-0438613PS50025
DomainLaminin_G_2

SLIT2 FAT4 SLIT1

3.00e-0440613PF02210
DomainLamG

SLIT2 FAT4 SLIT1

3.99e-0444613SM00282
DomainFol_N

SLIT2 SLIT1

5.66e-0411612IPR003645
DomainZnf_CXXC

TET1 CXXC4

5.66e-0411612IPR002857
DomainZF_CXXC

TET1 CXXC4

5.66e-0411612PS51058
DomainG_GB1_RHD3_dom

GBP5 RNF112

5.66e-0411612IPR030386
Domainzf-CXXC

TET1 CXXC4

5.66e-0411612PF02008
DomainGuanylate-bd_C

GBP5 RNF112

5.66e-0411612IPR003191
DomainGBP

GBP5 RNF112

5.66e-0411612PF02263
DomainZnF_UBP

USP20 USP33

5.66e-0411612SM00290
DomainGuanylate-bd_N

GBP5 RNF112

5.66e-0411612IPR015894
DomainFOLN

SLIT2 SLIT1

5.66e-0411612SM00274
DomainG_GB1_RHD3

GBP5 RNF112

5.66e-0411612PS51715
DomainLaminin_G

SLIT2 FAT4 SLIT1

9.00e-0458613IPR001791
DomainZnf_UBP

USP20 USP33

9.31e-0414612IPR001607
Domainzf-UBP

USP20 USP33

9.31e-0414612PF02148
DomainZF_UBP

USP20 USP33

9.31e-0414612PS50271
DomainUSP_CS

USP20 USP47 USP33

1.31e-0366613IPR018200
DomainIontro_rcpt

GRIN2C GRIN2D

1.55e-0318612IPR001320
DomainLig_chan-Glu_bd

GRIN2C GRIN2D

1.55e-0318612PF10613
DomainIono_rcpt_met

GRIN2C GRIN2D

1.55e-0318612IPR001508
DomainGlu/Gly-bd

GRIN2C GRIN2D

1.55e-0318612IPR019594
DomainLig_chan-Glu_bd

GRIN2C GRIN2D

1.55e-0318612SM00918
DomainCTCK_1

SLIT2 SLIT1

1.55e-0318612PS01185
DomainLig_chan

GRIN2C GRIN2D

1.55e-0318612PF00060
DomainPBPe

GRIN2C GRIN2D

1.55e-0318612SM00079
DomainUSP_1

USP20 USP47 USP33

1.55e-0370613PS00972
DomainUCH

USP20 USP47 USP33

1.62e-0371613PF00443
DomainUSP_2

USP20 USP47 USP33

1.62e-0371613PS00973
DomainUSP_3

USP20 USP47 USP33

1.68e-0372613PS50235
DomainUSP_dom

USP20 USP47 USP33

1.68e-0372613IPR028889
DomainPeptidase_C19_UCH

USP20 USP47 USP33

1.68e-0372613IPR001394
DomainPHD

PHF20 PHF19 BAZ1A

1.89e-0375613PF00628
DomainCT

SLIT2 SLIT1

2.32e-0322612SM00041
DomainCys_knot_C

SLIT2 SLIT1

3.00e-0325612IPR006207
DomainCTCK_2

SLIT2 SLIT1

3.00e-0325612PS01225
Domainzf-C2H2_6

PRDM10 ZNF667 RREB1 ZNF439 ZFP82

3.59e-03314615PF13912
Domain-

SLIT2 FAT4 SLIT1

3.71e-03956132.60.120.200
DomainEGF_Ca-bd_CS

SLIT2 FAT4 SLIT1

3.93e-0397613IPR018097
DomainEGF_CA

SLIT2 FAT4 SLIT1

4.16e-0399613PS01187
DomainAlkaline_phosphatase_core

ENPP3 ARSI

4.59e-0331612IPR017850
DomainAlkaline_Pase-like_a/b/a

ENPP3 ARSI

4.59e-0331612IPR017849
Domain-

ENPP3 ARSI

4.59e-03316123.40.720.10
DomainLRRCT

SLIT2 SLIT1

4.89e-0332612PF01463
DomainEGF-type_Asp/Asn_hydroxyl_site

SLIT2 FAT4 SLIT1

5.04e-03106613IPR000152
DomainANF_lig-bd_rcpt

GRIN2C GRIN2D

6.49e-0337612IPR001828
DomainANF_receptor

GRIN2C GRIN2D

6.49e-0337612PF01094
PathwayWP_NRXN1_DELETION_SYNDROME

NLGN3 GRIN2C GRIN2D

2.74e-0518473M48098
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

GRIN2C GRIN2D

1.08e-045472MM15655
PathwayKEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

1.08e-045472M47667
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

1.62e-046472M47668
PathwayWP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV

NLGN3 GRIN2C GRIN2D

1.77e-0433473M39875
PathwayREACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS

SLIT2 USP33

2.26e-047472MM15593
PathwayREACTOME_REGULATION_OF_COMMISSURAL_AXON_PATHFINDING_BY_SLIT_AND_ROBO

SLIT2 SLIT1

4.81e-0410472M27348
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_LIGAND_GATED_CA2_CHANNEL

GRIN2C GRIN2D

7.03e-0412472M47953
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

NLGN3 GRIN2C GRIN2D

8.51e-0456473M27616
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

1.11e-0315472M47691
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

NLGN3 GRIN2C GRIN2D

1.43e-0367473MM15327
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

1.61e-0318472M47761
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM

GRIN2C GRIN2D

1.79e-0319472M47677
PathwayBIOCARTA_NOS1_PATHWAY

GRIN2C GRIN2D

1.99e-0320472MM1445
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

GRIN2C GRIN2D

1.99e-0320472MM15485
PathwayREACTOME_SIGNALING_BY_ROBO_RECEPTORS

SLIT2 USP33

1.99e-0320472MM14974
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

GRIN2C GRIN2D

2.19e-0321472M27736
PathwayBIOCARTA_NOS1_PATHWAY

GRIN2C GRIN2D

2.19e-0321472M11650
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

GRIN2C GRIN2D

2.19e-0321472M838
PathwayREACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION

GRIN2C GRIN2D

2.19e-0321472M27944
PathwayWP_GDNFRET_SIGNALING_AXIS

SLIT2 FAT4

2.41e-0322472MM15887
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

GRIN2C GRIN2D

2.41e-0322472MM15104
PathwayREACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS

SLIT2 SLIT1 RPS26 USP33

2.54e-03172474M27876
PathwayREACTOME_LONG_TERM_POTENTIATION

GRIN2C GRIN2D

2.63e-0323472M27949
PathwayWP_GDNFRET_SIGNALING_AXIS

SLIT2 FAT4

2.63e-0323472M39814
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

NLGN3 GRIN2C GRIN2D

3.03e-0387473M27617
Pubmed

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.

ZC3H10 GGNBP2 PHF20 ZNF280D PHF19 BAZ1A ZC3H8 RBM10 ZNF254 KDM4A ZNF786

1.44e-07808611120412781
Pubmed

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.

GRIN2C GRIN2D

3.03e-06261229651654
Pubmed

Permissive corridor and diffusible gradients direct medial ganglionic eminence cell migration to the neocortex.

SLIT2 SLIT1

3.03e-06261212515855
Pubmed

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.

GRIN2C GRIN2D

3.03e-06261231110197
Pubmed

Steerable-filter based quantification of axonal populations at the developing optic chiasm reveal significant defects in Slit2(-/-) as well as Slit1(-/-)Slit2(-/-) embryos.

SLIT2 SLIT1

3.03e-06261223320558
Pubmed

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.

GRIN2C GRIN2D

3.03e-06261229317596
Pubmed

Slit1 and slit2 proteins control the development of the lateral olfactory tract.

SLIT2 SLIT1

3.03e-06261212097499
Pubmed

Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes.

SLIT2 SLIT1

3.03e-06261212200164
Pubmed

Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.

GRIN2C GRIN2D

3.03e-06261235057644
Pubmed

NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.

GRIN2C GRIN2D

3.03e-06261233766086
Pubmed

Directional guidance of neuronal migration in the olfactory system by the protein Slit.

SLIT2 SLIT1

3.03e-06261210432110
Pubmed

Deubiquitinases USP20/33 promote the biogenesis of tail-anchored membrane proteins.

USP20 USP33

3.03e-06261233792613
Pubmed

NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.

GRIN2C GRIN2D

3.03e-06261231786200
Pubmed

Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain.

SLIT2 SLIT1

9.07e-06361216162649
Pubmed

Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT.

SLIT2 USP33

9.07e-06361230896071
Pubmed

Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.

GRIN2C GRIN2D

9.07e-0636129718984
Pubmed

Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.

GRIN2C GRIN2D

9.07e-06361235867797
Pubmed

The noncoding RNA linc-ADAMTS5 cooperates with RREB1 to protect from intervertebral disc degeneration through inhibiting ADAMTS5 expression.

ADAMTS5 RREB1

9.07e-06361228341660
Pubmed

Identification of a deubiquitinating enzyme subfamily as substrates of the von Hippel-Lindau tumor suppressor.

USP20 USP33

9.07e-06361212056827
Pubmed

USP33, a new player in lung cancer, mediates Slit-Robo signaling.

SLIT2 USP33

9.07e-06361224981056
Pubmed

Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system.

SLIT2 SLIT1

9.07e-0636129813312
Pubmed

Facilitation of GluN2C-containing NMDA receptors in the external globus pallidus increases firing of fast spiking neurons and improves motor function in a hemiparkinsonian mouse model.

GRIN2C GRIN2D

9.07e-06361233421565
Pubmed

Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels.

GRIN2C GRIN2D

9.07e-0636129480759
Pubmed

Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.

USP20 USP33

9.07e-06361212865408
Pubmed

A molecular mechanism for the heparan sulfate dependence of slit-robo signaling.

SLIT2 SLIT1

9.07e-06361217062560
Pubmed

Conserved modularity and potential for alternate splicing in mouse and human Slit genes.

SLIT2 SLIT1

9.07e-06361212141424
Pubmed

New neurons follow the flow of cerebrospinal fluid in the adult brain.

SLIT2 SLIT1

9.07e-06361216410488
Pubmed

Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain.

SLIT2 SLIT1

9.07e-06361210364234
Pubmed

Intraislet SLIT-ROBO signaling is required for beta-cell survival and potentiates insulin secretion.

SLIT2 SLIT1

9.07e-06361224065825
Pubmed

Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits.

SLIT2 SLIT1

9.07e-06361216840550
Pubmed

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters.

ZNF711 ZFX

9.07e-06361232406922
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF711 RLF ZNF280D BAZ1A RACGAP1 KDM4A RREB1 ZFP82

1.09e-0560861836089195
Pubmed

Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling.

USP20 USP33

1.81e-05461221525354
Pubmed

The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.

USP20 USP33

1.81e-05461219424180
Pubmed

The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance.

SLIT2 SLIT1

1.81e-05461210433822
Pubmed

Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum.

GRIN2C GRIN2D

1.81e-0546128699248
Pubmed

Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel.

GRIN2C GRIN2D

1.81e-0546129768843
Pubmed

Multiple roles for slits in the control of cell migration in the rostral migratory stream.

SLIT2 SLIT1

1.81e-05461214960623
Pubmed

Contralateral migration of oculomotor neurons is regulated by Slit/Robo signaling.

SLIT2 SLIT1

1.81e-05461227770832
Pubmed

Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.

GRIN2C GRIN2D

1.81e-05461236309015
Pubmed

Slits contribute to the guidance of retinal ganglion cell axons in the mammalian optic tract.

SLIT2 SLIT1

1.81e-05461216828733
Pubmed

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

GRIN2C GRIN2D

3.02e-05561226875626
Pubmed

Slit and robo: expression patterns in lung development.

SLIT2 SLIT1

3.02e-05561212609596
Pubmed

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

GRIN2C GRIN2D

3.02e-05561226919761
Pubmed

Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.

GRIN2C GRIN2D

3.02e-0556127518475
Pubmed

Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum.

GRIN2C GRIN2D

3.02e-0556127518474
Pubmed

Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit.

GRIN2C GRIN2D

3.02e-0556129147327
Pubmed

Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina.

GRIN2C GRIN2D

3.02e-0556127510577
Pubmed

Neurotransmission and bipolar disorder: a systematic family-based association study.

GRIN2C GRIN2D

3.02e-05561218444252
Pubmed

Extracellular Ig domains 1 and 2 of Robo are important for ligand (Slit) binding.

SLIT2 SLIT1

3.02e-05561215207848
Pubmed

Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland.

GRIN2C GRIN2D

3.02e-0556128015722
Pubmed

Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain.

GRIN2C GRIN2D

3.02e-05561215003177
Pubmed

Slit2 signaling through Robo1 and Robo2 is required for retinal neovascularization.

SLIT2 SLIT1

3.02e-05561225894826
Pubmed

GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions.

GRIN2C GRIN2D

3.02e-0556127723623
Pubmed

Expression patterns of Slit and Robo family members in adult mouse spinal cord and peripheral nervous system.

SLIT2 SLIT1

3.02e-05561228234971
Pubmed

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene.

GRIN2C GRIN2D

3.02e-0556128756432
Pubmed

On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion.

SLIT2 SLIT1

3.02e-05561212954717
Pubmed

Slit1 is specifically expressed in the primary and secondary enamel knots during molar tooth cusp formation.

SLIT2 SLIT1

3.02e-05561211520671
Pubmed

Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.

GRIN2C GRIN2D

3.02e-05561212082569
Pubmed

Emergent growth cone responses to combinations of Slit1 and Netrin 1 in thalamocortical axon topography.

SLIT2 SLIT1

3.02e-05561222000108
Pubmed

Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.

GRIN2C GRIN2D

3.02e-05561221945132
Pubmed

Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina.

SLIT2 SLIT1

3.02e-05561216885222
Pubmed

Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins.

GRIN2C GRIN2D

3.02e-05561218233995
Pubmed

Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex.

GRIN2C GRIN2D

3.02e-05561211488959
Pubmed

Developmental changes in distribution of NMDA receptor channel subunit mRNAs.

GRIN2C GRIN2D

3.02e-0556121493227
Pubmed

N-methyl-D-aspartic acid receptor structure and function.

GRIN2C GRIN2D

3.02e-0556128036251
Pubmed

NMDA receptor activation by HIV-Tat protein is clade dependent.

GRIN2C GRIN2D

3.02e-05561219020013
Pubmed

Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals.

SLIT2 SLIT1

3.02e-05561221118670
Pubmed

PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islands.

TET1 PROSER1

3.02e-05561234667079
Pubmed

Slit proteins are not dominant chemorepellents for olfactory tract and spinal motor axons.

SLIT2 SLIT1

3.02e-05561211748139
Pubmed

Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord.

GRIN2C GRIN2D

3.02e-0556127929904
Pubmed

Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system.

SLIT2 SLIT1

4.52e-05661211804570
Pubmed

Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.

GRIN2C GRIN2D

4.52e-05661225760043
Pubmed

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.

GRIN2C GRIN2D

4.52e-05661223665428
Pubmed

SLITs suppress tumor growth in vivo by silencing Sdf1/Cxcr4 within breast epithelium.

SLIT2 SLIT1

4.52e-05661218829537
Pubmed

Slit antagonizes netrin-1 attractive effects during the migration of inferior olivary neurons.

SLIT2 SLIT1

4.52e-05661212051827
Pubmed

The role of Slit-Robo signaling in the generation, migration and morphological differentiation of cortical interneurons.

SLIT2 SLIT1

4.52e-05661218054781
Pubmed

Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse.

GRIN2C GRIN2D

4.52e-0566128996814
Pubmed

Slit2 is a repellent for retinal ganglion cell axons.

SLIT2 SLIT1

4.52e-05661210864954
Pubmed

Robo1 and robo2 control the development of the lateral olfactory tract.

SLIT2 SLIT1

4.52e-05661217360927
Pubmed

Slit2 and netrin 1 act synergistically as adhesive cues to generate tubular bi-layers during ductal morphogenesis.

SLIT2 SLIT1

4.52e-05661216439476
Pubmed

Pioneer longitudinal axons navigate using floor plate and Slit/Robo signals.

SLIT2 SLIT1

4.52e-05661218842816
Pubmed

Robo2 Receptor Gates the Anatomical Divergence of Neurons Derived From a Common Precursor Origin.

SLIT2 SLIT1

4.52e-05661234249921
Pubmed

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.

GRIN2C GRIN2D

4.52e-0566129458051
Pubmed

Autocrine/juxtaparacrine regulation of axon fasciculation by Slit-Robo signaling.

SLIT2 SLIT1

4.52e-05661222306607
Pubmed

Deubiquitinating enzyme USP33/VDU1 is required for Slit signaling in inhibiting breast cancer cell migration.

SLIT2 USP33

4.52e-05661219706539
Pubmed

NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.

GRIN2C GRIN2D

4.52e-05661215317856
Pubmed

Slit/Robo-mediated chemorepulsion of vagal sensory axons in the fetal gut.

SLIT2 SLIT1

4.52e-05661223161783
Pubmed

USP33 regulates centrosome biogenesis via deubiquitination of the centriolar protein CP110.

USP20 USP33

4.52e-05661223486064
Pubmed

Islet architecture: A comparative study.

SLIT2 SLIT1

6.32e-05761220606719
Pubmed

Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus.

GRIN2C GRIN2D

6.32e-05761212103442
Pubmed

VEGF-A and neuropilin 1 (NRP1) shape axon projections in the developing CNS via dual roles in neurons and blood vessels.

SLIT2 SLIT1

6.32e-05761228676569
Pubmed

MARCH2 promotes endocytosis and lysosomal sorting of carvedilol-bound β(2)-adrenergic receptors.

USP20 USP33

6.32e-05761223166351
Pubmed

Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.

GRIN2C GRIN2D

6.32e-05761223267846
Pubmed

Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.

GRIN2C GRIN2D

6.32e-05761219036954
Pubmed

Slit-Robo signals regulate pioneer axon pathfinding of the tract of the postoptic commissure in the mammalian forebrain.

SLIT2 SLIT1

6.32e-05761221688288
Pubmed

Slit molecules prevent entrance of trunk neural crest cells in developing gut.

SLIT2 SLIT1

6.32e-05761225490618
Pubmed

Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

GRIN2C GRIN2D

6.32e-05761222833210
Pubmed

HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.

GRIN2C GRIN2D

6.32e-05761222940423
Pubmed

Slit/Robo signaling mediates spatial positioning of spiral ganglion neurons during development of cochlear innervation.

SLIT2 SLIT1

8.42e-05861223884932
GeneFamilyPHD finger proteins

PHF20 PHF19 BAZ1A PHF11 NFX1 PHF7

1.33e-079048688
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF711 RLF PRDM10 ZNF254 ZNF667 ZNF510 ZNF230 RREB1 ZNF439 ZNF786 ZFP82 ZFX

2.63e-07718481228
GeneFamilyTudor domain containing

PHF20 PHF19 KDM4A

1.28e-0437483780
GeneFamilyGlutamate ionotropic receptor NMDA type subunits

GRIN2C GRIN2D

1.44e-0474821201
GeneFamilyUbiquitin specific peptidases

USP20 USP47 USP33

4.41e-0456483366
GeneFamilyZinc fingers CXXC-type

TET1 CXXC4

4.48e-0412482136
GeneFamilyZinc fingers CCCH-type

ZC3H10 ZC3H8

3.88e-033548273
CoexpressionGSE3565_CTRL_VS_LPS_INJECTED_DUSP1_KO_SPLENOCYTES_DN

PRKD2 UBE4B CSNK1G1 TET1 RPS26 TREML2

2.91e-06171616M6321
CoexpressionGSE21546_WT_VS_SAP1A_KO_DP_THYMOCYTES_UP

PRKD2 FAM111A BAZ1A CSNK1G1 PHF11 H1-9P

6.58e-06197616M7543
CoexpressionAtlasDevelopingGonad_e16.5_testes_emap-8444_k-means-cluster#4_top-relative-expression-ranked_1000

GGNBP2 UBE4B LIPG CSNK1G1 PHF7

2.34e-05123595gudmap_developingGonad_e16.5_testes_1000_k4
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ZC3H10 PHF19 ZNF254 ZFP82 C2CD5

3.34e-061676157e61c5d2cdcfa6a2e3484b3994aec6b64ad75f07
ToppCellmild_COVID-19_(asymptomatic)-RBC|World / disease group, cell group and cell class (v2)

NLGN3 PHF19 PHF7 ZNF439 USP20

3.54e-061696152bda6ab3f32e05cb7daf91eb7c39b4fcc9ae91bb
ToppCellmild_COVID-19_(asymptomatic)-RBC|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)

NLGN3 PHF19 PHF7 ZNF439 USP20

3.75e-0617161578491478ba65bad45238fe114f5251b2adea323d
ToppCell356C-Myeloid-Monocyte-CD16+_Monocyte|Monocyte / Donor, Lineage, Cell class and subclass (all cells)

ZC3H10 PHF19 ZNF254 ZFP82 C2CD5

3.85e-061726159dca1542145d88559527db7e0f6ad150df59ca2d
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)-|356C / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 RNF112 ZNF667 SRPX ARSI

4.43e-06177615cdfd2f0ee2f692271b1525e414b0f645cdadb1f6
ToppCell356C-Fibroblasts-Fibroblast-C_(Myofibroblast)|356C / Donor, Lineage, Cell class and subclass (all cells)

SLIT2 RNF112 ZNF667 SRPX ARSI

4.43e-06177615db222faaecbe5600da39277243c4e7e764eb63c9
Drugmetaphit

ASIC1 GRIN2C GRIN2D

1.00e-0516613CID000114745
Drugalpha-Santonin [481-06-1]; Down 200; 16.2uM; MCF7; HT_HG-U133A

SLIT2 PHF20 UBE4B KDM4A USP20 ZFX

1.50e-051986164353_DN
Drugcarbetapentane

ASIC1 GRIN2C GRIN2D

2.35e-0521613CID000002562
DrugD-G-G

RNF112 GRIN2C GRIN2D

3.12e-0523613CID000444866
DrugRS)-2-chloro-5-hydroxyphenylglycine

NFX1 GRIN2C GRIN2D

3.56e-0524613CID003645780
Drug5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione

GRIN2C GRIN2D

7.02e-055612ctd:C498554
Drug2-Aminoadipic Acid

GRIN2C GRIN2D

7.02e-055612ctd:D015074
Drug(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid

GRIN2C GRIN2D

7.02e-055612ctd:C491996
DrugSDZ EAA 494

GRIN2C GRIN2D

7.02e-055612ctd:C065286
DrugNaphthols

GRIN2C GRIN2D

1.05e-046612ctd:D009284
DrugMeperidine

GRIN2C GRIN2D

1.05e-046612DB00454
Drug1,5-(diethylamino)piperidine

GRIN2C GRIN2D

1.05e-046612CID000004025
DrugSAHA; Down 200; 10uM; PC3; HT_HG-U133A

PRDM10 BAZ1A PHF11 ZFX C2CD5

1.06e-041756151220_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

PRDM10 PHF11 RREB1 ZFX C2CD5

1.18e-041796152105_DN
DrugPhTX-343

TRPM7 GRIN2C GRIN2D

1.23e-0436613CID000159548
DrugTenocyclidine

GRIN2C GRIN2D

1.47e-047612DB01520
Drug3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid

GRIN2C GRIN2D

1.47e-047612ctd:C050592
Drugtetrazol-5-yl)glycine

GRIN2C GRIN2D

1.47e-047612CID000126383
Drughomoquinolinate

GRIN2C GRIN2D

1.47e-047612CID003080554
DrugS)-piperazine-2-carboxylic acid

GRIN2C GRIN2D

1.47e-047612CID001502069
DrugSKF 82958

NFX1 GRIN2C GRIN2D

1.56e-0439613CID000001225
DrugPramoxine hydrochloride [637-58-1]; Down 200; 12.2uM; MCF7; HT_HG-U133A

PHF20 ZNF280D ASIC1 NFX1 ZFX

1.64e-041926156054_DN
DrugMethylergometrine maleate [113-42-8]; Down 200; 8.8uM; PC3; HT_HG-U133A

FAT4 UBE4B CSNK1G1 ZNF667 ZFX

1.68e-041936156704_DN
DrugCyclizine hydrochloride [303-25-3]; Up 200; 13.2uM; HL60; HG-U133A

SLIT2 ZNF280D ASIC1 NFX1 ADAMTS5

1.77e-041956151731_UP
DrugLevopropoxyphene napsylate [5714-90-9]; Up 200; 7.4uM; MCF7; HT_HG-U133A

SLIT2 NFX1 ZNF510 SRPX ZNF230

1.77e-041956153543_UP
DrugLoxapine succinate [27833-64-3]; Down 200; 9uM; MCF7; HT_HG-U133A

PRKD2 FAM111A UBE4B PROSER1 USP20

1.81e-041966155293_DN
DrugNitrofurantoin [67-20-9]; Down 200; 16.8uM; MCF7; HT_HG-U133A

SLIT2 UBE4B AP5Z1 NFX1 USP20

1.81e-041966154697_DN
DrugAC1NNRU4

NFX1 GRIN2C GRIN2D

1.81e-0441613CID005126051
Drugfludrocortisone acetate; Up 200; 1uM; MCF7; HG-U133A

UBE4B RBM10 PHF11 NFX1 USP20

1.85e-04197615282_UP
DrugGuanadrel sulfate [22195-34-2]; Down 200; 7.6uM; PC3; HT_HG-U133A

ZNF280D UBE4B ZNF254 KDM4A ZFX

1.85e-041976157396_DN
DrugOxprenolol hydrochloride [6452-73-9]; Down 200; 13.2uM; HL60; HT_HG-U133A

ZNF280D ASIC1 ZNF254 ZNF667 ZFX

1.85e-041976156145_DN
DrugSulfamonomethoxine [1220-83-3]; Up 200; 14.2uM; PC3; HT_HG-U133A

PHF7 PROSER1 ZNF230 USP20 ZFX

1.85e-041976155843_UP
DrugSuprofen [40828-46-4]; Down 200; 15.4uM; PC3; HT_HG-U133A

ASIC1 ZNF667 PHF7 ZNF510 ZFX

1.90e-041986154005_DN
Drug6-chloroquinoxaline-2,3-diol

GRIN2C GRIN2D

1.96e-048612CID000081143
DrugES-242-1

GRIN2C GRIN2D

1.96e-048612CID000131976
DrugSDZ 220-581

GRIN2C GRIN2D

1.96e-048612CID000128019
Drug3alpha5betaHS

GRIN2C GRIN2D

1.96e-048612CID000165024
Drugneramexane

GRIN2C GRIN2D

1.96e-048612CID006433106
Drugpiperazine-2,3-dicarboxylic acid

GRIN2C GRIN2D

1.96e-048612CID000280973
DrugL-687,414

GRIN2C GRIN2D

1.96e-048612CID000125556
Diseaseuridine measurement

PRKD2 SLIT2

1.94e-0332602EFO_0010546
Diseasehyperuricemia

PRKD2 RREB1

2.06e-0333602EFO_0009104
Diseasephosphatidylcholine 38:2 measurement

TRHR LIPG

2.32e-0335602EFO_0010384
DiseaseGastric Adenocarcinoma

PRKD2 TRPM7

3.81e-0345602C0278701
Diseasecreatinine measurement

PRKD2 TRHR RNF112 PHF7 FAM47E RREB1 USP20

3.96e-03995607EFO_0004518
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GRIN2C GRIN2D

4.50e-0349602DOID:0060037 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
KKGIHRCTKCRLQFL

ZNF280D

471

Q6N043
KKCKICKLRSFFRKL

ARSI

546

Q5FYB1
RICLQGKCVDKTKKK

ADAMTS5

546

Q9UNA0
LSLILCNQCRGKKAK

FAT4

4521

Q6V0I7
LKKFCSRICKLLQAE

AP5Z1

21

O43299
ILNARCKICRKKGDA

BAZ1A

1146

Q9NRL2
KCGVQNFKRREKCFK

RBM10

221

P98175
RPRACLNFLKLCKIK

PPIL4

21

Q8WUA2
KRKNRRKNKCVCDIP

GGNBP2

376

Q9H3C7
CCCFFKRKRKKTAQR

CSNK1G1

406

Q9HCP0
RQKRKKKAYCPQIGC

NSMCE2

201

Q96MF7
KRCNKKRLCGRHKCN

NFX1

686

Q12986
FKLKCIFCKKRRKRT

KDM4A

826

O75164
TVCQACKKLLKGLFR

PRKD2

276

Q9BZL6
CKKLLKGLFRQGLQC

PRKD2

281

Q9BZL6
NRFKKGICLSCRKNR

LIPG

301

Q9Y5X9
RLCIQKFFPKKKCFI

GBP5

221

Q96PP8
KCLQCGKAFREKDKL

PRDM10

531

Q9NQV6
RCKRILEQAFKGGCK

PROSER1

116

Q86XN7
ISKECARKPNKKICR

NLGN3

156

Q9NZ94
RKLEKQGSCRKKCFD

ENPP3

46

O14638
IGKCKRRIVKCGKLH

FAM111A

191

Q96PZ2
ICKFRKCEELKKKPG

CXXC4

166

Q9H2H0
KRLIKGVRRVAKCHC

H1-9P

216

P60008
GCLIQARLCRLKKKA

C2CD5

511

Q86YS7
KFRCKVVDCLKFFRK

PHF20

451

Q9BVI0
GKECKRACNKTPIKR

FAM47E

376

Q6ZV65
CKIRKKKCEPGFARV

TREML2

56

Q5T2D2
KFRAAFRKLCNCKQK

TRHR

326

P34981
ARASRKICFVCKKKG

PHF7

91

Q9BWX1
CKFRVKVRVKRCGKL

SRPX

251

P78539
RIKFGKLSLKCRDCR

RACGAP1

306

Q9H0H5
KKRKRCGVCEPCQQK

TET1

586

Q8NFU7
IKHKLCRRGKCQKEA

ASIC1

461

P78348
KCRKCGKLFNRISPL

ZNF667

331

Q5HYK9
KAVGLKLKQCERCDR

WDR88

406

Q6ZMY6
ECRKICKQKRGLRSL

RNF112

96

Q9ULX5
TKRELVKCKKIFACK

RLF

1351

Q13129
KADKRKKVCSVCNKR

RREB1

1506

Q92766
KKLVRCKACADAGLL

UBE4B

821

O95155
RCKKKCDARKGLRFL

USP47

366

Q96K76
CGKEIKKKKCIFRLR

PHF19

326

Q5T6S3
KRIGQIKSKKFRCSA

SLIT2

466

O94813
EIQRGRKLKCKFCHK

PHF11

101

Q9UIL8
RKLKCKFCHKRGATV

PHF11

106

Q9UIL8
ERCKKLRNGVKYCKV

USP20

561

Q9Y2K6
PFQCLKCDKRFRLKG

ZNF786

536

Q8N393
KCKECGKAFRLRQKL

ZFP82

451

Q8N141
KPFECKECRKAFRLN

ZFP82

476

Q8N141
CKRCRKGFRQQSELK

ZFX

721

P17010
RKKPFKCEDCGKRLV

ZNF230

416

Q9UIE0
KCNECGKKFVRKAIL

ZNF510

601

Q9Y2H8
CARCVPKDKAIKKFV

RPS26

26

P62854
KFCLFCFRKLAKKGK

UGT2B15

511

P54855
RDFLKGDCQRGAKCK

ZC3H10

141

Q96K80
TKDQPLKCKRCKRGF

ZNF711

671

Q9Y462
RIGQIKSKKFRCSAK

SLIT1

476

O75093
LFCCICKRRKKDKTS

TRPM7

1141

Q96QT4
KRYKCLECGKAFKQL

ZNF254

376

O75437
EKCKKLRNGVKFCKV

USP33

591

Q8TEY7
SRKKLYECKQCGKAL

ZNF439

321

Q8NDP4
RKGKQICKYFLERKC

ZC3H8

191

Q8N5P1
KLCCKGFCIDILKKL

GRIN2C

451

Q14957
KRCCKGFCIDILKRL

GRIN2D

481

O15399