Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	GLUD1 GLUD2	4.97e-06	2	45	2	GO:0016639
GeneOntologyMolecularFunction	glutamate dehydrogenase [NAD(P)+] activity	GLUD1 GLUD2	4.97e-06	2	45	2	GO:0004353
GeneOntologyMolecularFunction	glutamate dehydrogenase (NAD+) activity	GLUD1 GLUD2	4.97e-06	2	45	2	GO:0004352
GeneOntologyMolecularFunction	glutamate dehydrogenase (NADP+) activity	GLUD1 GLUD2	4.97e-06	2	45	2	GO:0004354
GeneOntologyMolecularFunction	carnitine O-palmitoyltransferase activity	CPT2 CPT1C	2.97e-05	4	45	2	GO:0004095
GeneOntologyMolecularFunction	O-palmitoyltransferase activity	CPT2 CPT1C	4.94e-05	5	45	2	GO:0016416
GeneOntologyMolecularFunction	carnitine O-acyltransferase activity	CPT2 CPT1C	7.41e-05	6	45	2	GO:0016406
GeneOntologyMolecularFunction	L-leucine binding	GLUD1 GLUD2	1.04e-04	7	45	2	GO:0070728
GeneOntologyMolecularFunction	quaternary ammonium group transmembrane transporter activity	SLC22A8 SLC6A14	5.12e-04	15	45	2	GO:0015651
GeneOntologyMolecularFunction	amino acid binding	GLUD1 YARS2 GLUD2	5.96e-04	73	45	3	GO:0016597
GeneOntologyMolecularFunction	ephrin receptor activity	NTRK1 EPHA10	8.29e-04	19	45	2	GO:0005003
GeneOntologyMolecularFunction	oxidoreductase activity, acting on the CH-NH2 group of donors	GLUD1 GLUD2	9.20e-04	20	45	2	GO:0016638
GeneOntologyMolecularFunction	NAD+ binding	GLUD1 GLUD2	9.20e-04	20	45	2	GO:0070403
GeneOntologyMolecularFunction	odorant binding	OR5K2 OR5K1 OR6K6	2.93e-03	127	45	3	GO:0005549
GeneOntologyMolecularFunction	palmitoyltransferase activity	CPT2 CPT1C	3.15e-03	37	45	2	GO:0016409
GeneOntologyMolecularFunction	ADP binding	GLUD1 GLUD2	5.24e-03	48	45	2	GO:0043531
GeneOntologyBiologicalProcess	glutamate biosynthetic process	GLUD1 GLUD2	4.63e-05	5	45	2	GO:0006537
GeneOntologyBiologicalProcess	response to aluminum ion	GLUD1 GLUD2	6.94e-05	6	45	2	GO:0010044
GeneOntologyBiologicalProcess	glutamate catabolic process	GLUD1 GLUD2	1.29e-04	8	45	2	GO:0006538
Domain	ELFV_dehydrog_N	GLUD1 GLUD2	5.68e-06	2	45	2	PF02812
Domain	Glu/Leu/Phe/Val_DH_C	GLUD1 GLUD2	5.68e-06	2	45	2	IPR006096
Domain	Glu/Leu/Phe/Val_DH_dimer_dom	GLUD1 GLUD2	5.68e-06	2	45	2	IPR006097
Domain	Glu/Leu/Phe/Val_DH	GLUD1 GLUD2	5.68e-06	2	45	2	IPR006095
Domain	ELFV_dehydrog	GLUD1 GLUD2	5.68e-06	2	45	2	PF00208
Domain	ELFV_dehydrog	GLUD1 GLUD2	5.68e-06	2	45	2	SM00839
Domain	Glu/Leu/Phe/Val_DH_AS	GLUD1 GLUD2	5.68e-06	2	45	2	IPR033524
Domain	NAD_bind_Glu_DH	GLUD1 GLUD2	5.68e-06	2	45	2	IPR033922
Domain	GLFV_DEHYDROGENASE	GLUD1 GLUD2	5.68e-06	2	45	2	PS00074
Domain	-	LGALS13 LAMA5 FAT4 FAT3	7.98e-05	95	45	4	2.60.120.200
Domain	LAM_G_DOMAIN	LAMA5 FAT4 FAT3	1.04e-04	38	45	3	PS50025
Domain	Carn_acyltransf	CPT2 CPT1C	1.18e-04	7	45	2	PF00755
Domain	ACYLTRANSF_C_1	CPT2 CPT1C	1.18e-04	7	45	2	PS00439
Domain	Carn_acyl_trans	CPT2 CPT1C	1.18e-04	7	45	2	IPR000542
Domain	ACYLTRANSF_C_2	CPT2 CPT1C	1.18e-04	7	45	2	PS00440
Domain	Laminin_G_2	LAMA5 FAT4 FAT3	1.21e-04	40	45	3	PF02210
Domain	LamG	LAMA5 FAT4 FAT3	1.62e-04	44	45	3	SM00282
Domain	Laminin_G	LAMA5 FAT4 FAT3	3.68e-04	58	45	3	IPR001791
Domain	EGF-like_CS	LAMA5 FAT4 FBN3 FAT3 EPHA10	3.97e-04	261	45	5	IPR013032
Domain	EGF_2	LAMA5 FAT4 FBN3 FAT3 EPHA10	4.25e-04	265	45	5	PS01186
Domain	EGF_CA	FAT4 FBN3 FAT3	1.16e-03	86	45	3	PF07645
Domain	EGF_Ca-bd_CS	FAT4 FBN3 FAT3	1.65e-03	97	45	3	IPR018097
Domain	EGF_CA	FAT4 FBN3 FAT3	1.74e-03	99	45	3	PS01187
Domain	ASX_HYDROXYL	FAT4 FBN3 FAT3	1.80e-03	100	45	3	PS00010
Domain	ConA-like_dom	LGALS13 LAMA5 FAT4 FAT3	1.88e-03	219	45	4	IPR013320
Domain	hEGF	FAT4 FBN3	2.06e-03	28	45	2	PF12661
Domain	EGF-type_Asp/Asn_hydroxyl_site	FAT4 FBN3 FAT3	2.12e-03	106	45	3	IPR000152
Domain	EGF	LAMA5 FAT4 FBN3 FAT3	2.43e-03	235	45	4	SM00181
Domain	EGF-like_dom	LAMA5 FAT4 FBN3 FAT3	2.99e-03	249	45	4	IPR000742
Domain	EGF_CA	FAT4 FBN3 FAT3	3.16e-03	122	45	3	SM00179
Domain	EGF_1	LAMA5 FAT4 FBN3 FAT3	3.26e-03	255	45	4	PS00022
Domain	EGF-like_Ca-bd_dom	FAT4 FBN3 FAT3	3.31e-03	124	45	3	IPR001881
Domain	Pkinase_Tyr	NTRK1 EPHA10 GUCY2D	3.70e-03	129	45	3	PF07714
Domain	Ser-Thr/Tyr_kinase_cat_dom	NTRK1 EPHA10 GUCY2D	4.46e-03	138	45	3	IPR001245
Domain	Growth_fac_rcpt_	LAMA5 FAT4 FBN3	6.27e-03	156	45	3	IPR009030
Domain	-	DECR2 GLUD1 GLUD2	7.82e-03	169	45	3	3.40.50.720
Domain	NAD(P)-bd_dom	DECR2 GLUD1 GLUD2	8.33e-03	173	45	3	IPR016040
Pubmed	Critical role of the cysteine 323 residue in the catalytic activity of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.64e-06	2	45	2	15750346
Pubmed	Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum.	GLUD1 GLUD2	1.64e-06	2	45	2	21446915
Pubmed	Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA.	GLUD1 GLUD2	1.64e-06	2	45	2	1711373
Pubmed	Glutamate Delta-1 Receptor Regulates Inhibitory Neurotransmission in the Nucleus Accumbens Core and Anxiety-Like Behaviors.	GLUD1 GLUD2	1.64e-06	2	45	2	34173171
Pubmed	Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.	GLUD1 GLUD2	1.64e-06	2	45	2	28621566
Pubmed	Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection.	GLUD1 GLUD2	1.64e-06	2	45	2	18688271
Pubmed	The complex regulation of human glud1 and glud2 glutamate dehydrogenases and its implications in nerve tissue biology.	GLUD1 GLUD2	1.64e-06	2	45	2	22658952
Pubmed	GluD1 knockout mice with a pure C57BL/6N background show impaired fear memory, social interaction, and enhanced depressive-like behavior.	GLUD1 GLUD2	1.64e-06	2	45	2	32078638
Pubmed	Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate.	GLUD1 GLUD2	1.64e-06	2	45	2	20529287
Pubmed	Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.	GLUD1 GLUD2	1.64e-06	2	45	2	23595828
Pubmed	Determination of glutamate dehydrogenase activity and its kinetics in mouse tissues using metabolic mapping (quantitative enzyme histochemistry).	GLUD1 GLUD2	1.64e-06	2	45	2	25124006
Pubmed	GluD1 binds GABA and controls inhibitory plasticity.	GLUD1 GLUD2	1.64e-06	2	45	2	38060673
Pubmed	Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice.	GLUD1 GLUD2	1.64e-06	2	45	2	24593767
Pubmed	Unexpected histone H3 tail-clipping activity of glutamate dehydrogenase.	GLUD1 GLUD2	1.64e-06	2	45	2	23673664
Pubmed	Increases in anterograde axoplasmic transport in neurons of the hyper-glutamatergic, glutamate dehydrogenase 1 (Glud1) transgenic mouse: Effects of glutamate receptors on transport.	GLUD1 GLUD2	1.64e-06	2	45	2	38124277
Pubmed	Potentiation of neuronal activity by tonic GluD1 current in brain slices.	GLUD1 GLUD2	1.64e-06	2	45	2	37154294
Pubmed	Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.	GLUD1 GLUD2	1.64e-06	2	45	2	19015267
Pubmed	Interaction between glutamate dehydrogenase (GDH) and L-leucine catabolic enzymes: intersecting metabolic pathways.	GLUD1 GLUD2	1.64e-06	2	45	2	21621574
Pubmed	Lack of evidence for direct ligand-gated ion channel activity of GluD receptors.	GLUD1 GLUD2	1.64e-06	2	45	2	39052831
Pubmed	Deletion of glutamate dehydrogenase 1 (Glud1) in the central nervous system affects glutamate handling without altering synaptic transmission.	GLUD1 GLUD2	1.64e-06	2	45	2	22924626
Pubmed	Metabolism changes during aging in the hippocampus and striatum of glud1 (glutamate dehydrogenase 1) transgenic mice.	GLUD1 GLUD2	1.64e-06	2	45	2	24442550
Pubmed	Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia.	GLUD1 GLUD2	1.64e-06	2	45	2	28911206
Pubmed	The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity.	GLUD1 GLUD2	1.64e-06	2	45	2	27137930
Pubmed	Human GLUD1 and GLUD2 glutamate dehydrogenase localize to mitochondria and endoplasmic reticulum.	GLUD1 GLUD2	1.64e-06	2	45	2	19448744
Pubmed	GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.	GLUD1 GLUD2	1.64e-06	2	45	2	26440896
Pubmed	Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell-specific abrogation of the glutamate dehydrogenase.	GLUD1 GLUD2	1.64e-06	2	45	2	22875990
Pubmed	Study of structure-function relationships in human glutamate dehydrogenases reveals novel molecular mechanisms for the regulation of the nerve tissue-specific (GLUD2) isoenzyme.	GLUD1 GLUD2	1.64e-06	2	45	2	12742085
Pubmed	Nerve tissue-specific (GLUD2) and housekeeping (GLUD1) human glutamate dehydrogenases are regulated by distinct allosteric mechanisms: implications for biologic function.	GLUD1 GLUD2	1.64e-06	2	45	2	11032875
Pubmed	Molecular basis of human glutamate dehydrogenase regulation under changing energy demands.	GLUD1 GLUD2	1.64e-06	2	45	2	15578726
Pubmed	Important role of Ser443 in different thermal stability of human glutamate dehydrogenase isozymes.	GLUD1 GLUD2	1.64e-06	2	45	2	15044002
Pubmed	Single amino acid substitution (G456A) in the vicinity of the GTP binding domain of human housekeeping glutamate dehydrogenase markedly attenuates GTP inhibition and abolishes the cooperative behavior of the enzyme.	GLUD1 GLUD2	1.64e-06	2	45	2	11950837
Pubmed	Induction of excitatory and inhibitory presynaptic differentiation by GluD1.	GLUD1 GLUD2	1.64e-06	2	45	2	22138648
Pubmed	Localization of Human Glutamate Dehydrogenases Provides Insights into Their Metabolic Role and Their Involvement in Disease Processes.	GLUD1 GLUD2	1.64e-06	2	45	2	29943084
Pubmed	Glutamate Dehydrogenase Is Important for Ammonia Fixation and Amino Acid Homeostasis in Brain During Hyperammonemia.	GLUD1 GLUD2	1.64e-06	2	45	2	34220417
Pubmed	Glutamate dehydrogenase deficiency disrupts glutamate homeostasis in hippocampus and prefrontal cortex and impairs recognition memory.	GLUD1 GLUD2	1.64e-06	2	45	2	31898404
Pubmed	Birth and adaptive evolution of a hominoid gene that supports high neurotransmitter flux.	GLUD1 GLUD2	1.64e-06	2	45	2	15378063
Pubmed	Widening Spectrum of Cellular and Subcellular Expression of Human GLUD1 and GLUD2 Glutamate Dehydrogenases Suggests Novel Functions.	GLUD1 GLUD2	1.64e-06	2	45	2	27422263
Pubmed	Expression of human GLUD1 and GLUD2 glutamate dehydrogenases in steroid producing tissues.	GLUD1 GLUD2	1.64e-06	2	45	2	26241911
Pubmed	Postsynaptic δ1 glutamate receptor assembles and maintains hippocampal synapses via Cbln2 and neurexin.	GLUD1 GLUD2	4.91e-06	3	45	2	29784783
Pubmed	Isolation of a human brain cDNA for glutamate dehydrogenase.	GLUD1 GLUD2	4.91e-06	3	45	2	3585334
Pubmed	The structure of apo human glutamate dehydrogenase details subunit communication and allostery.	GLUD1 GLUD2	4.91e-06	3	45	2	12054821
Pubmed	GOT1 regulates CD8+ effector and memory T cell generation.	GLUD1 GLUD2	4.91e-06	3	45	2	36640309
Pubmed	Screening for new inhibitors of the human Mitochondrial Pyruvate Carrier and their effects on hepatic glucose production and diabetes.	GLUD1 GLUD2	4.91e-06	3	45	2	37871770
Pubmed	Trans-Synaptic Signaling through the Glutamate Receptor Delta-1 Mediates Inhibitory Synapse Formation in Cortical Pyramidal Neurons.	GLUD1 GLUD2	4.91e-06	3	45	2	31704028
Pubmed	Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning.	GLUD1 GLUD2	4.91e-06	3	45	2	23560106
Pubmed	Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase.	GLUD1 GLUD2	4.91e-06	3	45	2	29229616
Pubmed	The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.	ZIC1 ZIC3	4.91e-06	3	45	2	22024047
Pubmed	Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis.	GLUD1 GLUD2	4.91e-06	3	45	2	30002133
Pubmed	Glutamate delta-1 receptor regulates cocaine-induced plasticity in the nucleus accumbens.	GLUD1 GLUD2	4.91e-06	3	45	2	30315226
Pubmed	Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.	GLUD1 GLUD2	4.91e-06	3	45	2	20670938
Pubmed	Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans.	ZIC1 ZIC3	4.91e-06	3	45	2	14679585
Pubmed	Identification of disulfide bond formation between MitoNEET and glutamate dehydrogenase 1.	GLUD1 GLUD2	4.91e-06	3	45	2	24295216
Pubmed	Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation.	ZIC1 ZIC3	4.91e-06	3	45	2	15261827
Pubmed	The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired.	ZIC1 ZIC3	4.91e-06	3	45	2	8557628
Pubmed	The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.	GLUD1 GLUD2	9.81e-06	4	45	2	23663782
Pubmed	Enriched expression of GluD1 in higher brain regions and its involvement in parallel fiber-interneuron synapse formation in the cerebellum.	GLUD1 GLUD2	9.81e-06	4	45	2	24872547
Pubmed	Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.	ZIC1 ZIC3	9.81e-06	4	45	2	15895369
Pubmed	Essential role of GluD1 in dendritic spine development and GluN2B to GluN2A NMDAR subunit switch in the cortex and hippocampus reveals ability of GluN2B inhibition in correcting hyperconnectivity.	GLUD1 GLUD2	9.81e-06	4	45	2	25721396
Pubmed	Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity.	CPT2 CPT1C	9.81e-06	4	45	2	11095714
Pubmed	An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.	ZIC1 ZIC3	9.81e-06	4	45	2	30297839
Pubmed	GLUD1 determines murine muscle stem cell fate by controlling mitochondrial glutamate levels.	GLUD1 GLUD2	9.81e-06	4	45	2	39121856
Pubmed	The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions.	CPT2 CPT1C	9.81e-06	4	45	2	26041663
Pubmed	A restriction fragment length polymorphism at murine Glud locus co-segregates with Rib-1, Es-10, and Tcra on chromosome 14.	GLUD1 GLUD2	9.81e-06	4	45	2	2566156
Pubmed	Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.	ZIC1 ZIC3	9.81e-06	4	45	2	11053430
Pubmed	A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.	ZIC1 ZIC3	9.81e-06	4	45	2	7931345
Pubmed	Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors.	RPL10L MPST LAMA5 CPT2 ADAM10 SNRNP200 CPT1C GLUD1 YARS2 GLUD2	1.30e-05	1451	45	10	30550785
Pubmed	Myogenic repressor I-mfa interferes with the function of Zic family proteins.	ZIC1 ZIC3	1.63e-05	5	45	2	15207726
Pubmed	SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.	GLUD1 GLUD2	1.63e-05	5	45	2	16959573
Pubmed	Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14.	GLUD1 GLUD2	1.63e-05	5	45	2	2045113
Pubmed	Proximity of the CTLA-1 serine esterase and Tcr alpha loci in mouse and man.	GLUD1 GLUD2	1.63e-05	5	45	2	3182016
Pubmed	Genomic organization and chromosomal localization of the mouse synexin gene.	GLUD1 GLUD2	1.63e-05	5	45	2	8053909
Pubmed	Macrophage-derived glutamine boosts satellite cells and muscle regeneration.	GLUD1 GLUD2	1.63e-05	5	45	2	33116312
Pubmed	Chromosomal assignment of 11 loci in the rat by mouse-rat somatic hybrids and linkage.	GLUD1 GLUD2	1.63e-05	5	45	2	7873882
Pubmed	Genomics of the human carnitine acyltransferase genes.	CPT2 CPT1C	2.45e-05	6	45	2	11001805
Pubmed	The human glutamate dehydrogenase gene family: gene organization and structural characterization.	GLUD1 GLUD2	2.45e-05	6	45	2	8486350
Pubmed	Physical and functional interactions between Zic and Gli proteins.	ZIC1 ZIC3	2.45e-05	6	45	2	11238441
Pubmed	Zic2 patterns binocular vision by specifying the uncrossed retinal projection.	ZIC1 ZIC3	3.42e-05	7	45	2	13678579
Pubmed	Distribution of a reeler gene-related antigen in the developing cerebellum: an immunohistochemical study with an allogeneic antibody CR-50 on normal and reeler mice.	ZIC1 ZIC3	3.42e-05	7	45	2	8863127
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	FAT4 FAT3	3.42e-05	7	45	2	16059920
Pubmed	Identification of quantitative trait loci for haloperidol-induced catalepsy on mouse chromosome 14.	GLUD1 GLUD2	3.42e-05	7	45	2	10454512
Pubmed	Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity.	FAT4 FAT3	3.42e-05	7	45	2	22510986
Pubmed	RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis.	GLUD1 GLUD2	3.42e-05	7	45	2	19498109
Pubmed	The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.	ZIC1 ZIC3	4.56e-05	8	45	2	9070329
Pubmed	Atypical cadherin FAT4 orchestrates lymphatic endothelial cell polarity in response to flow.	LAMA5 FAT4	4.56e-05	8	45	2	32182215
Pubmed	GluD1 is a signal transduction device disguised as an ionotropic receptor.	GLUD1 GLUD2	4.56e-05	8	45	2	34135511
Pubmed	Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα.	GLUD1 GLUD2	4.56e-05	8	45	2	34857752
Pubmed	Localization of Tfap2β, Casq2, Penk, Zic1, and Zic3 Expression in the Developing Retina, Muscle, and Sclera of the Embryonic Mouse Eye.	ZIC1 ZIC3	4.56e-05	8	45	2	31638440
Pubmed	Imbalance of excitatory/inhibitory synaptic protein expression in iPSC-derived neurons from FOXG1(+/-) patients and in foxg1(+/-) mice.	GLUD1 GLUD2	4.56e-05	8	45	2	26443267
Pubmed	Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic vascular system.	GLUD1 GLUD2	5.86e-05	9	45	2	8415706
Pubmed	Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice.	GLUD1 GLUD2	5.86e-05	9	45	2	9756038
Pubmed	Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues.	GLUD1 GLUD2	5.86e-05	9	45	2	2293612
Pubmed	Spatiotemporal expression of Zic genes during vertebrate inner ear development.	ZIC1 ZIC3	7.32e-05	10	45	2	23606270
Pubmed	Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.	ZIC1 ZIC3	7.32e-05	10	45	2	15136147
Pubmed	CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.	ZIC1 ZIC3	7.32e-05	10	45	2	18298960
Pubmed	An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19.	ECEL1 SNRNP200	7.32e-05	10	45	2	23500468
Pubmed	A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.	ZIC1 ZIC3	7.32e-05	10	45	2	21211521
Pubmed	Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.	ZIC1 ZIC3	8.94e-05	11	45	2	22623663
Pubmed	Absence of functional peroxisomes does not lead to deficiency of enzymes involved in cholesterol biosynthesis.	GLUD1 GLUD2	8.94e-05	11	45	2	11792727
Pubmed	Functional synergy of a human-specific and an ape-specific metabolic regulator in human neocortex development.	GLUD1 GLUD2	8.94e-05	11	45	2	38658571
Pubmed	Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a.	GLUD1 GLUD2	1.07e-04	12	45	2	7896292
Cytoband	3q11.2	OR5K2 OR5K1	3.01e-04	26	45	2	3q11.2
GeneFamily	Cadherin related	FAT4 FAT3	4.06e-04	17	32	2	24
Drug	oleoylcarnitine	CPT2 CPT1C GLUD1 GLUD2	2.38e-08	16	45	4	CID006441392
Drug	acetyl-L-carnitine	CPT2 ADAM10 CPT1C GLUD1 GLUD2	6.59e-07	84	45	5	CID000000001
Drug	palmitoylcarnitine	LGALS13 CPT2 CPT1C GLUD1 GLUD2	1.73e-06	102	45	5	CID000000461
Drug	triethyl lead chloride	CXCR1 GLUD1 GLUD2	3.23e-06	15	45	3	CID000014019
Drug	phenyltriethoxysilane	GLUD1 GLUD2	3.82e-06	2	45	2	CID000013075
Drug	methylmercuric bromide	GLUD1 GLUD2	3.82e-06	2	45	2	CID000068175
Drug	5-methylisophthalate	GLUD1 GLUD2	3.82e-06	2	45	2	CID000068137
Drug	G-3SH	GLUD1 GLUD2	3.82e-06	2	45	2	CID000174237
Drug	x 1 s	GLUD1 GLUD2	3.82e-06	2	45	2	CID000409694
Drug	iodoacetyldiethylstilbestrol	GLUD1 GLUD2	3.82e-06	2	45	2	CID006455327
Drug	ED20	ADAM10 NTRK1 GLUD1 GLUD2	5.22e-06	58	45	4	CID000062790
Drug	adipic acid	CPT2 SLC22A8 GLUD1 GLUD2	5.22e-06	58	45	4	CID000000196
Drug	AC1L193Y	CPT2 CPT1C GLUD1 GLUD2	8.25e-06	65	45	4	CID000000380
Drug	methoxyethylmercury	GLUD1 GLUD2	1.14e-05	3	45	2	CID000115155
Drug	4-methylumbelliferyl laurate	GLUD1 GLUD2	1.14e-05	3	45	2	CID000600674
Drug	lenthionine	GLUD1 GLUD2	1.14e-05	3	45	2	CID000067521
Drug	mildiomycin	GLUD1 GLUD2	1.14e-05	3	45	2	CID000125665
Drug	methylmercuric iodide	GLUD1 GLUD2	1.14e-05	3	45	2	CID000067347
Drug	2-bromopalmitoylcarnitine	CPT2 CPT1C	1.14e-05	3	45	2	CID003082365
Drug	methyl benzoquate	GLUD1 GLUD2	2.29e-05	4	45	2	CID000026383
Drug	8-BDB-TADP	GLUD1 GLUD2	2.29e-05	4	45	2	CID000130791
Drug	cadina-3,9-diene	GLUD1 GLUD2	2.29e-05	4	45	2	CID000010657
Drug	luxabendazole	GLUD1 GLUD2	2.29e-05	4	45	2	CID000072019
Drug	AC1L9CUQ	GLUD1 GLUD2	2.29e-05	4	45	2	CID000442451
Drug	ureidoglycine	GLUD1 GLUD2	2.29e-05	4	45	2	CID000439649
Drug	HCFC 225ca	CPT2 CPT1C	2.29e-05	4	45	2	CID000061112
Drug	N-butylmaleimide	GLUD1 GLUD2	2.29e-05	4	45	2	CID000239780
Drug	Ivin	GLUD1 GLUD2	2.29e-05	4	45	2	CID000014083
Drug	alpha-methylglutamate	GLUD1 GLUD2	2.29e-05	4	45	2	CID000095440
Drug	pentenoic acid	GLUD1 GLUD2	2.29e-05	4	45	2	CID000012299
Drug	R225A	CPT2 CPT1C	2.29e-05	4	45	2	CID000062353
Drug	2b E2	GLUD1 GLUD2	2.29e-05	4	45	2	CID005327076
Drug	alpha-ketoglutaramate	GLUD1 GLUD2	2.29e-05	4	45	2	CID000000048
Drug	palmitoylcholine	CPT2 CPT1C	2.29e-05	4	45	2	CID000151731
Drug	1-pheg	GLUD1 GLUD2	3.81e-05	5	45	2	CID000152041
Drug	bathocuproine	GLUD1 GLUD2	3.81e-05	5	45	2	CID000065149
Drug	TDGA-carnitine	CPT2 CPT1C	3.81e-05	5	45	2	CID000196388
Drug	4 t ha	CPT2 CPT1C	3.81e-05	5	45	2	CID000124503
Drug	choline sulfate	GLUD1 GLUD2	3.81e-05	5	45	2	CID000000485
Drug	l-413	GLUD1 GLUD2	3.81e-05	5	45	2	CID000012475
Drug	5'-FSBAzA	GLUD1 GLUD2	3.81e-05	5	45	2	CID000130430
Drug	adenine N1-oxide	GLUD1 GLUD2	3.81e-05	5	45	2	CID000093557
Drug	AC1NRA4I	GLUD1 GLUD2	3.81e-05	5	45	2	CID005287695
Drug	bezafibroyl CoA	CPT2 CPT1C	3.81e-05	5	45	2	CID000176137
Drug	isosteviol lactone	GLUD1 GLUD2	3.81e-05	5	45	2	CID000401559
Drug	3-aminopicolinate	GLUD1 GLUD2	3.81e-05	5	45	2	CID000073836
Drug	AC1L32HG	SLC22A8 GLUD1 GLUD2	4.14e-05	34	45	3	CID000107645
Drug	Tween 20	CPT2 CPT1C GLUD1 GLUD2	4.20e-05	98	45	4	CID000443314
Drug	S-(-)-Etomoxir	MYO18B CPT2 CPT1C SQLE	4.55e-05	100	45	4	CID000060765
Drug	alpha-monofluoromethylputrescine	GLUD1 GLUD2	5.70e-05	6	45	2	CID000134201
Drug	AC1L2K2J	CPT2 CPT1C	5.70e-05	6	45	2	CID000073552
Drug	TG-CoA	CPT2 CPT1C	5.70e-05	6	45	2	CID000124781
Drug	dadAB	GLUD1 GLUD2	5.70e-05	6	45	2	CID000022626
Drug	pisolithin A	CPT2 CPT1C	5.70e-05	6	45	2	CID000000355
Drug	N-methylhydantoin	GLUD1 GLUD2	5.70e-05	6	45	2	CID000069217
Drug	Emid	GLUD1 GLUD2	5.70e-05	6	45	2	CID000074798
Drug	FOX 988	CPT2 CPT1C	5.70e-05	6	45	2	CID005491458
Drug	dimethylmalonate	GLUD1 GLUD2	5.70e-05	6	45	2	CID000007943
Drug	PDCoA	CPT2 CPT1C	5.70e-05	6	45	2	CID000125034
Drug	AC1L8SA5	GLUD1 GLUD2	5.70e-05	6	45	2	CID000407285
Drug	ME(O)HP	CPT2 CPT1C	5.70e-05	6	45	2	CID000119096
Drug	NSC 88147	CPT2 CPT1C	5.70e-05	6	45	2	CID000258814
Drug	3-Hydroxy-5,5-dimethylhexanoic acid	CPT2 CPT1C	5.70e-05	6	45	2	CID000192450
Drug	2-methyl-1,2,3,4-tetrahydroisoquinoline	GLUD1 GLUD2	5.70e-05	6	45	2	CID000015362
Drug	diazonium-1-H-tetrazole	GLUD1 GLUD2	5.70e-05	6	45	2	CID000188312
Drug	AC1L2UAM	CPT2 CPT1C	5.70e-05	6	45	2	CID000128706
Drug	3-amino-5,5-dimethylhexanoic acid	CPT2 CPT1C	5.70e-05	6	45	2	CID010397086
Drug	lanosol	GLUD1 GLUD2	5.70e-05	6	45	2	CID000078659
Drug	AC1L448Y	GLUD1 GLUD2	5.70e-05	6	45	2	CID000200389
Drug	2-BDB-TAMP	GLUD1 GLUD2	5.70e-05	6	45	2	CID000127220
Drug	isodiazinon	GLUD1 GLUD2	5.70e-05	6	45	2	CID000133913
Drug	AC1L1AH5	LGALS13 CPT2 CPT1C GLUD1 GLUD2	6.44e-05	215	45	5	CID000000986
Drug	carbophenothion	GLUD1 GLUD2	7.97e-05	7	45	2	CID000013081
Drug	37474A	GLUD1 GLUD2	7.97e-05	7	45	2	CID004330138
Drug	AC1L1B5W	GLUD1 GLUD2	7.97e-05	7	45	2	CID000001296
Drug	2-oxoglutaconic acid	GLUD1 GLUD2	7.97e-05	7	45	2	CID006443759
Drug	d-serine methyl ester hydrochloride	GLUD1 GLUD2	7.97e-05	7	45	2	CID000090387
Drug	acetoacetate	CPT2 CPT1C GLUD1 GLUD2	9.86e-05	122	45	4	CID000000096
Drug	2'(3')-O-(2,4,6-trinitrophenyl)-ADP	GLUD1 GLUD2	1.06e-04	8	45	2	CID000644359
Drug	6-chloroquinoxaline-2,3-diol	GLUD1 GLUD2	1.06e-04	8	45	2	CID000081143
Drug	Nessler's reagent	GLUD1 GLUD2	1.06e-04	8	45	2	CID000024542
Drug	2-heptanol	GLUD1 GLUD2	1.06e-04	8	45	2	CID000010976
Drug	myristoylcarnitine	CPT2 CPT1C	1.06e-04	8	45	2	CID003413344
Drug	iminoglutarate	GLUD1 GLUD2	1.06e-04	8	45	2	CID000152649
Drug	bidisomide	GLUD1 GLUD2	1.06e-04	8	45	2	CID000059798
Drug	Pheg	GLUD1 GLUD2	1.06e-04	8	45	2	CID003080746
Drug	AC1MQ2IK	GLUD1 GLUD2	1.06e-04	8	45	2	CID003394958
Drug	UK5099	CPT2 CPT1C	1.06e-04	8	45	2	CID006438504
Drug	AC1N690Y	GLUD1 GLUD2	1.06e-04	8	45	2	CID004256264
Drug	methylthiopropionylcarnitine	CPT2 CPT1C	1.06e-04	8	45	2	CID000194919
Drug	AD-143	CPT2 CPT1C	1.06e-04	8	45	2	CID000333663
Drug	trimethyllead chloride	GLUD1 GLUD2	1.06e-04	8	45	2	CID000223969
Drug	AC1O5S5Y	CPT2 CPT1C	1.06e-04	8	45	2	CID006439672
Drug	benzophenone	LGALS13 GLUD1 GLUD2	1.10e-04	47	45	3	CID000003102
Drug	NHS-ASA	GLUD1 GLUD2	1.36e-04	9	45	2	CID003035647
Drug	DCQX	GLUD1 GLUD2	1.36e-04	9	45	2	CID000001845
Drug	adipamide	GLUD1 GLUD2	1.36e-04	9	45	2	CID000012364
Drug	temelastine	GLUD1 GLUD2	1.36e-04	9	45	2	CID000055482
Drug	dimethyl L-glutamate	GLUD1 GLUD2	1.36e-04	9	45	2	CID000093032
Drug	Asparagusate	GLUD1 GLUD2	1.36e-04	9	45	2	CID000016682
Disease	fascioliasis (biomarker_via_orthology)	GLUD1 GLUD2	5.65e-06	3	41	2	DOID:885 (biomarker_via_orthology)
Disease	childhood absence epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	2.82e-05	6	41	2	DOID:1825 (biomarker_via_orthology)
Disease	Joubert syndrome (implicated_via_orthology)	TMEM237 ZIC1	3.94e-05	7	41	2	DOID:0050777 (implicated_via_orthology)
Disease	X-13684 measurement	MPST GTF2H1	5.25e-05	8	41	2	EFO_0800737
Disease	hepatic encephalopathy (biomarker_via_orthology)	GLUD1 GLUD2	1.96e-04	15	41	2	DOID:13413 (biomarker_via_orthology)
Disease	Squamous cell carcinoma of esophagus	FAT4 KMT2D FAT3	3.15e-04	95	41	3	C0279626
Disease	Ciliopathies	TMEM237 GUCY2D ZIC3	4.85e-04	110	41	3	C4277690
Disease	temporal lobe epilepsy (biomarker_via_orthology)	GLUD1 GLUD2	8.54e-04	31	41	2	DOID:3328 (biomarker_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
GFTALHYAAMHGRAR	ASB7	81	Q9H672
RLDFHAHGRHFNLRM	ADAM10	61	O14672
DGHFHTVIARRAGMA	FAT4	4056	Q6V0I7
EQGFFRMHHLRGVSS	FBN3	2746	Q75N90
GGRLDMNHGFVHHIR	C2orf68	16	Q2NKX9
KQGGRGEFHHVAMFL	DPP10	391	Q8N608
AAMGQGFDRHLFALR	CPT2	546	P23786
AGNLHSMIHVGLVFR	OR5K2	151	Q8NHB8
AGMVYLAGLHFVHRD	NTRK1	636	P04629
RFGHHMAVLRGAVFA	KLHL34	516	Q8N239
HRMSARTHGLLGQFF	ITIH1	821	P19827
MGLAGAFLAHYVRHR	GUCY2D	476	Q02846
PVAMVHARDGTHRFF	HHIPL1	196	Q96JK4
GFRIAEIFMRHGCHT	DECR2	41	Q9NUI1
MSHGALDGFLRRHEG	EPHA10	726	Q5JZY3
VGRAMTFHGHGFLRL	LAMA5	3121	O15230
NRHFGMALGALFVHE	ECEL1	446	O95672
AGNLHSMIHVGLVFR	OR5K1	151	Q8NHB7
HIDFGRFLGHAQMFG	PIK3C2B	1211	O00750
AFRFRVHFGNHVVMN	LGALS13	51	Q9UHV8
QHVAVFHRGRFFRMG	CPT1C	331	Q8TCG5
FHRGRFFRMGTHSRN	CPT1C	336	Q8TCG5
NVGLHSMRYLHRFGA	GLUD1	311	P00367
GRAFHHGRFIMSLRK	SQLE	221	Q14534
FVGLHMHGFRRTLRN	FAT3	3661	Q8TDW7
LGDFRHTMHVGRAGD	CDC42EP4	31	Q9H3Q1
NFRHGFLKILAMHGL	CXCR1	311	P25024
GGFLMAGSLARRLHH	B3GNT7	301	Q8NFL0
ILDRVGSMGHFQFLH	SLC22A8	6	Q8TCC7
NVGLHSMRYLHRFGA	GLUD2	311	P49448
RGMKNGAGRFFHLDH	MORN3	166	Q6PF18
LFSMFPHAHRGGLLF	OR6K6	41	Q8NGW6
GRDGFHMRVRLHPFH	RPL10L	81	Q96L21
MFRAFGHHAVSLLDG	MPST	116	P25325
VLFGDGHRLIMRGAH	MRPL53	66	Q96EL3
HLVDFLAAVGGHFRM	YARS2	181	Q9Y2Z4
VHRAFRMIGLFSHGF	TMEM237	221	Q96Q45
AAHHGPGAFFRYMRQ	ZIC3	231	O60481
RFNHHSAMVLAAGLR	GTF2H1	306	P32780
LSVHAGIRGEAMRFH	PJVK	171	Q0ZLH3
HRTGYADHMGLTRFR	MYO18B	1256	Q8IUG5
GFAIHHAGMTRVDRT	SNRNP200	781	O75643
AHHGAGAFFRYMRQP	ZIC1	206	Q15915
AFHMILAGHRFSKAG	TRAPPC8	561	Q9Y2L5
AGFAIFSILGHMAHI	SLC6A14	361	Q9UN76
HMFRVGGLVFHAIGQ	KMT2D	5176	O14686