Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartate:glutamate, proton antiporter activity	SLC25A12 SLC25A13	1.11e-05	2	67	2	GO:0000515
GeneOntologyMolecularFunction	3-sulfino-L-alanine: proton, glutamate antiporter activity	SLC25A12 SLC25A13	1.11e-05	2	67	2	GO:0000514
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC25A12 SLC13A1 SLC12A9 SLC25A13 SLC28A3 CPOX ATP1A2	6.62e-05	301	67	7	GO:0022853
GeneOntologyMolecularFunction	amino acid:monoatomic cation antiporter activity	SLC25A12 SLC25A13	1.10e-04	5	67	2	GO:0140848
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC25A12 SLC13A1 SLC12A9 SLC17A9 SLC25A13 SLC28A3 CPOX ATP1A2	1.90e-04	477	67	8	GO:0022804
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC25A12 SLC13A1 SLC12A9 SLC17A9 SLC25A13 SLC28A3	4.71e-04	296	67	6	GO:0015291
GeneOntologyMolecularFunction	P-type sodium transporter activity	CPOX ATP1A2	4.91e-04	10	67	2	GO:0008554
GeneOntologyMolecularFunction	P-type sodium:potassium-exchanging transporter activity	CPOX ATP1A2	4.91e-04	10	67	2	GO:0005391
GeneOntologyMolecularFunction	L-aspartate transmembrane transporter activity	SLC25A12 SLC25A13	4.91e-04	10	67	2	GO:0015183
GeneOntologyMolecularFunction	sulfur amino acid transmembrane transporter activity	SLC25A12 SLC25A13	5.98e-04	11	67	2	GO:0000099
GeneOntologyMolecularFunction	P-type potassium transmembrane transporter activity	CPOX ATP1A2	5.98e-04	11	67	2	GO:0008556
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	SLC25A12 KCNA5 SLC13A1 SLC12A9 SLC25A13 SLC28A3 CPOX ATP1A2 ANO8	9.30e-04	758	67	9	GO:0015318
GeneOntologyMolecularFunction	sulfur compound transmembrane transporter activity	SLC25A12 SLC13A1 SLC25A13	1.13e-03	61	67	3	GO:1901682
GeneOntologyMolecularFunction	C4-dicarboxylate transmembrane transporter activity	SLC25A12 SLC25A13	1.13e-03	15	67	2	GO:0015556
GeneOntologyMolecularFunction	L-glutamate transmembrane transporter activity	SLC25A12 SLC25A13	1.13e-03	15	67	2	GO:0005313
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC25A12 KCNA5 SLC13A1 SLC12A9 SLC25A13 SLC28A3 CPOX ATP1A2	1.15e-03	627	67	8	GO:0022890
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC25A12 KCNA5 SLC13A1 SLC12A9 SLC25A13 SLC28A3 CPOX ATP1A2 ANO8	1.27e-03	793	67	9	GO:0015075
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC25A12 KCNA5 SLC13A1 SLC12A9 SLC25A13 SLC28A3 CPOX ATP1A2	1.66e-03	664	67	8	GO:0008324
GeneOntologyMolecularFunction	lamin binding	NARF TMEM201	1.83e-03	19	67	2	GO:0005521
GeneOntologyMolecularFunction	acidic amino acid transmembrane transporter activity	SLC25A12 SLC25A13	2.03e-03	20	67	2	GO:0015172
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCNA5 SLC12A9 CPOX ATP1A2	2.40e-03	167	67	4	GO:0015079
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC13A1 SLC28A3 CPOX ATP1A2	2.62e-03	171	67	4	GO:0015081
GeneOntologyMolecularFunction	R-SMAD binding	SMURF1 MEN1	3.42e-03	26	67	2	GO:0070412
GeneOntologyMolecularFunction	monoatomic anion:monoatomic cation symporter activity	SLC13A1 SLC12A9	3.42e-03	26	67	2	GO:0015296
GeneOntologyMolecularFunction	calcium ion binding	PITPNM1 SCUBE1 STAB2 SLC25A12 DSC2 SLC25A13 CDH4 F7	3.49e-03	749	67	8	GO:0005509
GeneOntologyMolecularFunction	transporter activity	PITPNM1 SLC25A12 KCNA5 SLC13A1 SLC12A9 SLC17A9 SLC25A13 SLC28A3 CPOX ATP1A2 ANO8	3.54e-03	1289	67	11	GO:0005215
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNA5 SLC13A1 SLC12A9 SLC28A3 CPOX ATP1A2	4.65e-03	465	67	6	GO:0046873
GeneOntologyMolecularFunction	dicarboxylic acid transmembrane transporter activity	SLC25A12 SLC25A13	4.84e-03	31	67	2	GO:0005310
Domain	Cadherin_pro	DSC2 CDH4	2.71e-04	7	68	2	PF08758
Domain	Cadherin_pro_dom	DSC2 CDH4	3.61e-04	8	68	2	IPR014868
Domain	ACTINS_1	ACTA1 ACTC1	3.61e-04	8	68	2	PS00406
Domain	Cadherin_pro	DSC2 CDH4	3.61e-04	8	68	2	SM01055
Domain	ARM-rpt_dom	ARMCX2 ARMCX1	7.03e-04	11	68	2	IPR006911
Domain	Arm_2	ARMCX2 ARMCX1	7.03e-04	11	68	2	PF04826
Domain	EGF_3	SCUBE1 STAB2	8.42e-04	12	68	2	PF12947
Domain	EGF_dom	SCUBE1 STAB2	8.42e-04	12	68	2	IPR024731
Domain	GPCR_2_secretin-like	FZD2 ADGRA2 ADGRA3	1.36e-03	60	68	3	IPR000832
Domain	GPCR_2-like	FZD2 ADGRA2 ADGRA3	1.36e-03	60	68	3	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	FZD2 ADGRA2 ADGRA3	1.43e-03	61	68	3	PS50261
Domain	Actin_CS	ACTA1 ACTC1	1.52e-03	16	68	2	IPR004001
Domain	ACTINS_2	ACTA1 ACTC1	1.71e-03	17	68	2	PS00432
Domain	-	CRYZ PTGR2	1.92e-03	18	68	2	3.90.180.10
Domain	Actin/actin-like_CS	ACTA1 ACTC1	1.92e-03	18	68	2	IPR020902
Domain	ADH_zinc_N	CRYZ PTGR2	2.15e-03	19	68	2	PF00107
Domain	ADH_SF_Zn-type	CRYZ PTGR2	2.15e-03	19	68	2	IPR002085
Domain	ADH_C	CRYZ PTGR2	2.15e-03	19	68	2	IPR013149
Domain	ACTINS_ACT_LIKE	ACTA1 ACTC1	2.15e-03	19	68	2	PS01132
Domain	-	FZD2 MUSK	2.62e-03	21	68	2	1.10.2000.10
Domain	Frizzled_dom	FZD2 MUSK	3.42e-03	24	68	2	IPR020067
Domain	FZ	FZD2 MUSK	3.42e-03	24	68	2	PS50038
Domain	Fz	FZD2 MUSK	3.42e-03	24	68	2	PF01392
Domain	GroES-like	CRYZ PTGR2	3.42e-03	24	68	2	IPR011032
Domain	Cadherin_cytoplasmic-dom	DSC2 CDH4	3.71e-03	25	68	2	IPR000233
Domain	Cadherin_C	DSC2 CDH4	3.71e-03	25	68	2	PF01049
Domain	Cys-rich_flank_reg_C	LRFN3 ADGRA2 ADGRA3	4.33e-03	90	68	3	IPR000483
Domain	Homeobox_metazoa	NKX2-8 NKX2-3 NKX1-1	4.33e-03	90	68	3	IPR020479
Domain	LRRCT	LRFN3 ADGRA2 ADGRA3	4.33e-03	90	68	3	SM00082
Domain	HRM	ADGRA2 ADGRA3	4.64e-03	28	68	2	PF02793
Domain	Aden_trnslctor	SLC25A12 SLC25A13	4.64e-03	28	68	2	IPR002113
Domain	Catenin_binding_dom	DSC2 CDH4	4.98e-03	29	68	2	IPR027397
Domain	-	DSC2 CDH4	4.98e-03	29	68	2	4.10.900.10
Domain	Ig_I-set	LRFN3 PAPLN MUSK ADGRA3	5.09e-03	190	68	4	IPR013098
Domain	I-set	LRFN3 PAPLN MUSK ADGRA3	5.09e-03	190	68	4	PF07679
Domain	Actin	ACTA1 ACTC1	5.67e-03	31	68	2	IPR004000
Domain	Actin	ACTA1 ACTC1	5.67e-03	31	68	2	PF00022
Domain	ACTIN	ACTA1 ACTC1	5.67e-03	31	68	2	SM00268
Domain	Mit_carrier	SLC25A12 SLC25A13	6.04e-03	32	68	2	IPR002067
Domain	GPS	ADGRA2 ADGRA3	6.80e-03	34	68	2	SM00303
Domain	GPS	ADGRA2 ADGRA3	7.19e-03	35	68	2	PF01825
Domain	GPS	ADGRA2 ADGRA3	7.60e-03	36	68	2	PS50221
Domain	GPS	ADGRA2 ADGRA3	8.01e-03	37	68	2	IPR000203
Domain	G_PROTEIN_RECEP_F2_1	ADGRA2 ADGRA3	9.32e-03	40	68	2	PS00649
Domain	GPCR_2_extracellular_dom	ADGRA2 ADGRA3	9.32e-03	40	68	2	IPR001879
Domain	ARM_REPEAT	ARMCX2 ARMCX1	9.32e-03	40	68	2	PS50176
Domain	G_PROTEIN_RECEP_F2_3	ADGRA2 ADGRA3	9.32e-03	40	68	2	PS50227
Domain	ARM	ARMCX2 ARMCX1	9.32e-03	40	68	2	SM00185
Domain	EGF_CA	SCUBE1 STAB2 F7	1.00e-02	122	68	3	SM00179
Domain	EGF-like_Ca-bd_dom	SCUBE1 STAB2 F7	1.05e-02	124	68	3	IPR001881
Pubmed	Mice lacking factor VII develop normally but suffer fatal perinatal bleeding.	ACTA1 ACTC1 F7	2.60e-07	7	69	3	9384381
Pubmed	Calcium-induced conformational changes of the regulatory domain of human mitochondrial aspartate/glutamate carriers.	SLC25A12 SLC25A13	3.88e-06	2	69	2	25410934
Pubmed	Rescue of skeletal muscle alpha-actin-null mice by cardiac (fetal) alpha-actin.	ACTA1 ACTC1	3.88e-06	2	69	2	19468071
Pubmed	Investigation of changes in skeletal muscle alpha-actin expression in normal and pathological human and mouse hearts.	ACTA1 ACTC1	3.88e-06	2	69	2	20706863
Pubmed	alpha-Actin proteins and gene transcripts are colocalized in embryonic mouse muscle.	ACTA1 ACTC1	3.88e-06	2	69	2	1893870
Pubmed	Differential regulation of coproporphyrinogen oxidase gene between erythroid and nonerythroid cells.	GATA1 CPOX	3.88e-06	2	69	2	9787185
Pubmed	A 5' duplication of the alpha-cardiac actin gene in BALB/c mice is associated with abnormal levels of alpha-cardiac and alpha-skeletal actin mRNAs in adult cardiac tissue.	ACTA1 ACTC1	3.88e-06	2	69	2	3023046
Pubmed	Exogenous aralar/slc25a12 can replace citrin/slc25a13 as malate aspartate shuttle component in liver.	SLC25A12 SLC25A13	3.88e-06	2	69	2	36967723
Pubmed	AGC1/2, the mitochondrial aspartate-glutamate carriers.	SLC25A12 SLC25A13	3.88e-06	2	69	2	27132995
Pubmed	Expression of the aspartate/glutamate mitochondrial carriers aralar1 and citrin during development and in adult rat tissues.	SLC25A12 SLC25A13	3.88e-06	2	69	2	12084073
Pubmed	Transcripts of alpha-cardiac and alpha-skeletal actins are early markers for myogenesis in the mouse embryo.	ACTA1 ACTC1	3.88e-06	2	69	2	3075543
Pubmed	ARMCX Family Gene Expression Analysis and Potential Prognostic Biomarkers for Prediction of Clinical Outcome in Patients with Gastric Carcinoma.	ARMCX2 ARMCX1	3.88e-06	2	69	2	32685472
Pubmed	The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein.	SLC25A12 SLC25A13	3.88e-06	2	69	2	10369257
Pubmed	Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle.	SLC25A12 SLC25A13	3.88e-06	2	69	2	17213189
Pubmed	A developmental study of the abnormal expression of alpha-cardiac and alpha-skeletal actins in the striated muscle of a mutant mouse.	ACTA1 ACTC1	3.88e-06	2	69	2	2731651
Pubmed	A fetal skeletal muscle actin mRNA in the mouse and its identity with cardiac actin mRNA.	ACTA1 ACTC1	3.88e-06	2	69	2	6897014
Pubmed	Chromatin remodelling complex dosage modulates transcription factor function in heart development.	KCNA5 GATA1 ACTC1	4.98e-06	17	69	3	21304516
Pubmed	Bmp2 regulates the interaction between EPDCs and myocytes in cardiac OFT.	ACTA1 ACTC1	1.16e-05	3	69	2	22647617
Pubmed	Lineage tree for the venous pole of the heart: clonal analysis clarifies controversial genealogy based on genetic tracing.	ACTA1 ACTC1	1.16e-05	3	69	2	22855565
Pubmed	Actin and myosin genes are transcriptionally regulated during mouse skeletal muscle development.	ACTA1 ACTC1	1.16e-05	3	69	2	1728592
Pubmed	ALEX1, a novel human armadillo repeat protein that is expressed differentially in normal tissues and carcinomas.	ARMCX2 ARMCX1	1.16e-05	3	69	2	11162520
Pubmed	Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma.	ACTA1 ACTC1	1.16e-05	3	69	2	14507647
Pubmed	Actin-DBP: the perfect structural fit?	ACTA1 ACTC1	1.16e-05	3	69	2	12554937
Pubmed	Reexamination of chromosomal loci of human muscle actin genes by fluorescence in situ hybridization.	ACTA1 ACTC1	1.16e-05	3	69	2	7780165
Pubmed	Direct binding of the human homologue of the Drosophila disc large tumor suppressor gene to seven-pass transmembrane proteins, tumor endothelial marker 5 (TEM5), and a novel TEM5-like protein.	ADGRA2 ADGRA3	1.16e-05	3	69	2	15021905
Pubmed	The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis.	ACTA1 ACTC1	1.16e-05	3	69	2	12438125
Pubmed	Comparison of three actin-coding sequences in the mouse; evolutionary relationships between the actin genes of warm-blooded vertebrates.	ACTA1 ACTC1	1.16e-05	3	69	2	3084797
Pubmed	The genes coding for the cardiac muscle actin, the skeletal muscle actin and the cytoplasmic beta-actin are located on three different mouse chromosomes.	ACTA1 ACTC1	1.16e-05	3	69	2	6641707
Pubmed	Slc25a13-knockout mice harbor metabolic deficits but fail to display hallmarks of adult-onset type II citrullinemia.	SLC25A12 SLC25A13	2.32e-05	4	69	2	14701727
Pubmed	Phosphorylation of spinophilin modulates its interaction with actin filaments.	ACTA1 ACTC1	2.32e-05	4	69	2	12417592
Pubmed	Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria.	SLC25A12 SLC25A13	2.32e-05	4	69	2	11566871
Pubmed	Transcriptional regulation of actin and myosin genes during differentiation of a mouse muscle cell line.	ACTA1 ACTC1	2.32e-05	4	69	2	2201580
Pubmed	High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility.	SLC25A12 SLC13A1 SLC25A13	2.92e-05	30	69	3	19401682
Pubmed	Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin.	CCT5 ACTA1	3.86e-05	5	69	2	11580270
Pubmed	The A-to-I RNA Editing Enzyme Adar1 Is Essential for Normal Embryonic Cardiac Growth and Development.	ACTA1 ACTC1	3.86e-05	5	69	2	32362246
Pubmed	Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.	CCT5 ACTA1 SMURF1 ACTC1 PFKP	4.01e-05	191	69	5	33762435
Pubmed	Expression pattern of LRR and Ig domain-containing protein (LRRIG protein) in the early mouse embryo.	LRFN3 ADGRA2 ADGRA3	4.28e-05	34	69	3	18848646
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	RCC1L SLC12A9 CCT5 GLI3 SLC25A13 AEBP2 SMURF1 CPOX MAPK6 PFKP MEN1	5.72e-05	1327	69	11	32694731
Pubmed	Virus assembly and plasma membrane domains: which came first?	ACTA1 ACTC1	5.79e-05	6	69	2	22989508
Pubmed	HIV-1 protease cleaves actin during acute infection of human T-lymphocytes.	ACTA1 ACTC1	5.79e-05	6	69	2	1540415
Pubmed	HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motility.	ACTA1 ACTC1	5.79e-05	6	69	2	11709093
Pubmed	Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein.	ACTA1 ACTC1	5.79e-05	6	69	2	9971772
Pubmed	Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin.	ACTA1 ACTC1	5.79e-05	6	69	2	10049817
Pubmed	Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants.	ACTA1 ACTC1	5.79e-05	6	69	2	12009869
Pubmed	Apoptosis in the developing mouse heart.	ACTA1 ACTC1	5.79e-05	6	69	2	16881058
Pubmed	HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury.	ACTA1 ACTC1	5.79e-05	6	69	2	23811015
Pubmed	Retroviral assembly and budding occur through an actin-driven mechanism.	ACTA1 ACTC1	5.79e-05	6	69	2	19883584
Pubmed	Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells.	ACTA1 ACTC1	5.79e-05	6	69	2	21917091
Pubmed	HIV-1 Gag protein associates with F-actin present in microfilaments.	ACTA1 ACTC1	5.79e-05	6	69	2	8661406
Pubmed	A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA.	ACTA1 ACTC1	5.79e-05	6	69	2	23017337
Pubmed	Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin.	ACTA1 ACTC1	5.79e-05	6	69	2	10074138
Pubmed	Synaptodendritic recovery following HIV Tat exposure: neurorestoration by phytoestrogens.	ACTA1 ACTC1	5.79e-05	6	69	2	23875777
Pubmed	Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton.	ACTA1 ACTC1	5.79e-05	6	69	2	9841925
Pubmed	HIV-1 replication from after cell entry to the nuclear periphery.	ACTA1 ACTC1	8.09e-05	7	69	2	17504171
Pubmed	The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry.	ACTA1 ACTC1	8.09e-05	7	69	2	22535526
Pubmed	There exist at least 30 human G-protein-coupled receptors with long Ser/Thr-rich N-termini.	ADGRA2 ADGRA3	8.09e-05	7	69	2	12565841
Pubmed	siRNA and pharmacological inhibition of endocytic pathways to characterize the differential role of macropinocytosis and the actin cytoskeleton on cellular uptake of dextran and cationic cell penetrating peptides octaarginine (R8) and HIV-Tat.	ACTA1 ACTC1	8.09e-05	7	69	2	22465675
Pubmed	Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice.	ACTA1 ACTC1	8.09e-05	7	69	2	19118250
Pubmed	A Novel Mouse Model for Cilia-Associated Cardiovascular Anomalies with a High Penetrance of Total Anomalous Pulmonary Venous Return.	ACTA1 ACTC1	8.09e-05	7	69	2	30289203
Pubmed	NKX2 gene expression in neuroectoderm but not in mesendodermally derived structures depends on sonic hedgehog in mouse embryos.	NKX2-8 NKX2-3	8.09e-05	7	69	2	10603087
Pubmed	Selective targeting of ITK blocks multiple steps of HIV replication.	ACTA1 ACTC1	8.09e-05	7	69	2	18443296
Pubmed	The trinity of the cortical actin in the initiation of HIV-1 infection.	ACTA1 ACTC1	8.09e-05	7	69	2	22640593
Pubmed	Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production.	ACTA1 ACTC1	1.08e-04	8	69	2	14694110
Pubmed	Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.	ACTA1 ACTC1	1.08e-04	8	69	2	20147394
Pubmed	Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm.	GATA1 ETV2	1.08e-04	8	69	2	21911838
Pubmed	Cloning and characterization of a novel cardiac-specific kinase that interacts specifically with cardiac troponin I.	ACTA1 ACTC1	1.08e-04	8	69	2	12721663
Pubmed	Myod and H19-Igf2 locus interactions are required for diaphragm formation in the mouse.	ACTA1 ACTC1	1.08e-04	8	69	2	23406902
Pubmed	Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization.	ACTA1 ACTC1	1.08e-04	8	69	2	23260110
Pubmed	Skeletal muscle phenotypes initiated by ectopic MyoD in transgenic mouse heart.	ACTA1 ACTC1	1.08e-04	8	69	2	1618148
Pubmed	Investigation of genetic linkage between myosin and actin genes using an interspecific mouse back-cross.	ACTA1 ACTC1	1.08e-04	8	69	2	2983233
Pubmed	Reduced versican cleavage due to Adamts9 haploinsufficiency is associated with cardiac and aortic anomalies.	ACTA1 ACTC1	1.08e-04	8	69	2	20096780
Pubmed	ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.	TMEM201 CRYZ DSC2 FURIN SLC25A13 ACTA1 NUP133 ACTC1 PODXL2	1.08e-04	952	69	9	38569033
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PRDM8 SLC25A12 PYROXD1 SLC25A13 ACTA1 ACTC1 CPOX ATP1A2 MAPK6 PFKP MEN1	1.20e-04	1442	69	11	35575683
Pubmed	Modulation of cardiac growth and development by HOP, an unusual homeodomain protein.	ACTA1 ACTC1	1.38e-04	9	69	2	12297046
Pubmed	Sequence and chromosomal assignment of human BAPX1, a bagpipe-related gene, to 4p16.1: a candidate gene for skeletal dysplasia.	NKX2-8 NKX2-3	1.38e-04	9	69	2	9344671
Pubmed	Genome-wide association study (GWAS) for molar-incisor hypomineralization (MIH).	SCUBE1 SLC28A3	1.38e-04	9	69	2	23918034
Pubmed	Cytoskeletal proteins inside human immunodeficiency virus type 1 virions.	ACTA1 ACTC1	1.38e-04	9	69	2	8892894
Pubmed	Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).	SMURF1 NKX2-3	1.38e-04	9	69	2	20228798
Pubmed	Functional interaction between the cytoplasmic leucine-zipper domain of HIV-1 gp41 and p115-RhoGEF.	ACTA1 ACTC1	1.38e-04	9	69	2	10556093
Pubmed	HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells.	ACTA1 ACTC1	1.38e-04	9	69	2	18775311
Pubmed	Muscle-specific gene expression during myogenesis in the mouse.	ACTA1 ACTC1	1.38e-04	9	69	2	7787235
Pubmed	The expression of myosin genes in developing skeletal muscle in the mouse embryo.	ACTA1 ACTC1	1.73e-04	10	69	2	2211821
Pubmed	Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.	ACTA1 ACTC1	1.73e-04	10	69	2	21749862
Pubmed	Non-viral cellular substrates for human immunodeficiency virus type 1 protease.	ACTA1 ACTC1	1.73e-04	10	69	2	1991513
Pubmed	Gelsolin activity controls efficient early HIV-1 infection.	ACTA1 ACTC1	1.73e-04	10	69	2	23575248
Pubmed	Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus.	ACTA1 ACTC1	1.73e-04	10	69	2	1907279
Pubmed	Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin.	FURIN ACTC1	1.73e-04	10	69	2	9811571
Pubmed	Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.	MAPK6 CDH4	1.73e-04	10	69	2	8444355
Pubmed	Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks.	GLI3 FOXD1	1.73e-04	10	69	2	33006313
Pubmed	ACMG recommendations for reporting of incidental findings in clinical exome and genome sequencing.	DSC2 ACTC1 MEN1	2.03e-04	57	69	3	23788249
Pubmed	The Eutherian Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro and Trak2.	ARMCX2 ARMCX1	2.11e-04	11	69	2	22569362
Pubmed	CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function.	ACTA1 ACTC1	2.11e-04	11	69	2	30962377
Pubmed	N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton.	ACTA1 ACTC1	2.11e-04	11	69	2	23294842
Pubmed	Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity.	ACTA1 ACTC1	2.11e-04	11	69	2	8136524
Pubmed	Quantitative proteomic analysis of lentiviral vectors using 2-DE.	ACTA1 ACTC1	2.11e-04	11	69	2	19639585
Pubmed	FRS2α-mediated FGF signals suppress premature differentiation of cardiac stem cells through regulating autophagy activity.	ACTA1 ACTC1	2.11e-04	11	69	2	22207710
Pubmed	Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.	ACTC1 ADGRA2 CDH4	2.13e-04	58	69	3	24144296
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	TCTN3 TMEM201 SLC25A12 CCT5 SLC25A13 NUP133 PFKP	2.14e-04	613	69	7	22268729
Pubmed	HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting Gα(i2) for degradation through ubiquitination.	ACTA1 ACTC1	2.53e-04	12	69	2	23071112
Pubmed	A homeodomain feedback circuit underlies step-function interpretation of a Shh morphogen gradient during ventral neural patterning.	NKX2-8 GLI3	2.53e-04	12	69	2	21062862
Cytoband	Xq21.33-q22.2	ARMCX2 ARMCX1	2.23e-06	2	69	2	Xq21.33-q22.2
Cytoband	20q13.3	COL9A3 CDH4	4.16e-04	20	69	2	20q13.3
Cytoband	12q23.3	STAB2 TMEM119	1.28e-03	35	69	2	12q23.3
Cytoband	1q42.13	ACTA1 NUP133	2.50e-03	49	69	2	1q42.13
GeneFamily	Immunoglobulin like domain containing\|Adhesion G protein-coupled receptors, subfamily A	ADGRA2 ADGRA3	1.81e-05	3	45	2	911
GeneFamily	Actins	ACTA1 ACTC1	9.03e-05	6	45	2	929
GeneFamily	Solute carriers	SLC25A12 SLC13A1 SLC12A9 SLC17A9 SLC25A13 SLC28A3	4.15e-04	395	45	6	752
GeneFamily	NKL subclass homeoboxes and pseudogenes	NKX2-8 NKX2-3 NKX1-1	6.17e-04	67	45	3	519
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRFN3 PAPLN MUSK ADGRA3	6.79e-04	161	45	4	593
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMCX2 ARMCX1	5.13e-03	43	45	2	409
ToppCell	Neuroendocrine-neuroendo-1\|World / Class top	APLP1 PODXL2 CHKB CDH4 F7 MEN1	3.67e-07	180	69	6	50fdd182a083380899b5943cb5f55ffd77e2a7d4
ToppCell	wk_20-22-Mesenchymal-Chondrocyte-Resting_chondrocyte\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	COL9A3 ATP1A2 CHKB TSPYL4 ADGRA3	9.34e-06	182	69	5	03a5a02acd48f0eb210485348bfe0cd21f486215
ToppCell	(5)_Fibroblast-K_(Pericytes)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	KCNA5 ACTA1 ACTC1 ATP1A2 CHKB	1.34e-05	196	69	5	e3c89c5bd674289738d5590ebfd30c605f5156a5
ToppCell	(5)_Fibroblasts-(5)_Fibroblast-K_(Pericytes)\|(5)_Fibroblasts / Lung cell shreds - cell class (v4) and cell subclass (v4)	KCNA5 ACTA1 ACTC1 ATP1A2 CHKB	1.34e-05	196	69	5	541b1fcf509e362f6f48720046cb5378aaf7c591
ToppCell	Macroglial-Astrocytes\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GLI3 PAPLN ATP1A2 PFKP ADGRA3	1.47e-05	200	69	5	941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_NOS-7\|TCGA-Stomach / Sample_Type by Project: Shred V9	SCUBE1 KCNA5 BHMT2 ATP1A2	4.54e-05	127	69	4	5e4d110cc6e68cd8fc7a4771a65e6f8cd83e7721
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Oprk1_(Claustrum_cortex)\|Striatum / BrainAtlas - Mouse McCarroll V32	PRDM8 SCUBE1 HTR1A FURIN	4.68e-05	128	69	4	7e3f5cea91af005f08d8e9340fb8630bf1c887c3
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6\|Striatum / BrainAtlas - Mouse McCarroll V32	PRDM8 SCUBE1 HTR1A FURIN	4.68e-05	128	69	4	a876303c852db2af9418d1a1711d7c950805018a
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Excitatory_Neuron.Slc17a6.Oprk1_(Claustrum_cortex)-\|Striatum / BrainAtlas - Mouse McCarroll V32	PRDM8 SCUBE1 HTR1A FURIN	4.68e-05	128	69	4	388062f840fd04cb8087f27a9a78e7a192920e3e
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells-Mast-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRDM8 SLC13A1 GATA1 ARHGAP30	5.44e-05	133	69	4	81189e8516a431d5890a0909f9fc7c82ec3442bc
ToppCell	Parenchymal-10x3prime_v2-Stromal-Pericyte-Muscle_pericyte_systemic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	PODXL2 ATP1A2 ADGRA2 F7	6.82e-05	141	69	4	dcc56aef1b31bfe0de84cb0b5c77d242681cf19c
ToppCell	Control-Hematopoietic_Mast-Mast_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRDM8 SCUBE1 BHMT2 ARHGAP30	7.01e-05	142	69	4	a81f7ea4516a869c7c9b9a3f4ef74844ff9fffcd
ToppCell	Control-Hematopoietic_Mast-Mast_cells-T-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRDM8 SCUBE1 BHMT2 ARHGAP30	7.01e-05	142	69	4	70f8c1be134835e0d21e6d426b7122f0f5d3d3e5
ToppCell	Control-Hematopoietic_Mast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PRDM8 SCUBE1 BHMT2 ARHGAP30	7.01e-05	142	69	4	db9b7acbab730ae391a362f1ca8177507e52250d
ToppCell	TCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Mucinous-3\|TCGA-Stomach / Sample_Type by Project: Shred V9	STAB2 SLC13A1 TMEM119 ADGRA2	8.23e-05	148	69	4	c95a732163050cfb5d604c2a4c9eb1afa9f19a95
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_NKT-iNKT/MAIT-T-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PITPNM1 ARHGAP30 PFKP ANO8	1.11e-04	160	69	4	5c931e859acf67c1c8664941e0e44d195f8ba75b
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM119 FZD2 FOXD1 LRRC74B	1.25e-04	165	69	4	4cdd80580d5638fd649280ba3893251c2f898f3f
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMEM119 FZD2 FOXD1 LRRC74B	1.25e-04	165	69	4	c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCell	facs-Mammary_Gland-Mammary_Gland-3m-Epithelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ACTA1 GATA1 ACTC1 MUSK	1.31e-04	167	69	4	69caf4a53805f8c104d7dd8f88665fc992e23720
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ACTC1 ATP1A2 FZD2 FOXD1	1.31e-04	167	69	4	4ae9f2c5df13463709ea880ab035965fd99e7626
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ACTC1 ATP1A2 FZD2 FOXD1	1.31e-04	167	69	4	4e58f9bf1e9d47720c871776ec34513ded4de9b7
ToppCell	Hippocampus-Endothelial-ENDOTHELIAL_TIP\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TMEM119 ADGRA2 MUSK FOXD1	1.34e-04	168	69	4	26aa96b2b547d11941cb803995ea3d302ee0518c
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM119 ATP1A2 FZD2 FOXD1	1.34e-04	168	69	4	9930bd63b60c03f0152838a79eef77da1c2dd8e5
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	TMEM201 ACTC1 PAPLN FZD2	1.37e-04	169	69	4	ea600c63cf9572bc4b3cad6392f67bd0d92c7fc9
ToppCell	368C-Myeloid-Macrophage-SPP1+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	TMEM201 ACTC1 PAPLN FZD2	1.44e-04	171	69	4	26b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM119 ATP1A2 FZD2 FOXD1	1.44e-04	171	69	4	2e43fb129ee9bdc3b31febc43c10f959bf0f4a7d
ToppCell	frontal_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM119 ATP1A2 FZD2 FOXD1	1.44e-04	171	69	4	e219a1aa59a96e4bc3e2eacf985679174a51de41
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-lymphatic_endothelial-LEC1_(ACKR4+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	STAB2 BHMT2 TSPYL4 ADGRA2	1.50e-04	173	69	4	85083b9ce20351dd69aa2327ad087b848b4307ff
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 ACTA1 ACTC1 ATP1A2	1.50e-04	173	69	4	ecbf7167d4bec685e3460d826318544946f5f5c2
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 ACTA1 ACTC1 ATP1A2	1.50e-04	173	69	4	b8dc978c52de64afba21ff6cb32e79f07167448e
ToppCell	primary_visual_cortex-Non-neuronal-leptomeningeal_cell\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM119 FZD2 MUSK FOXD1	1.54e-04	174	69	4	2891ab2fd05eb4bbd239d1a2865f21ef7f2df39e
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM4-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SLC17A9 GATA1 PAPLN MAPK6	1.54e-04	174	69	4	fe105550a43b935affc73e32796115d20328a2f8
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM4\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	SLC17A9 GATA1 PAPLN MAPK6	1.54e-04	174	69	4	9191f6abb37ca65da5105f91e21689d11ec1059b
ToppCell	primary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM119 FZD2 MUSK FOXD1	1.54e-04	174	69	4	eade55f86ef1f7a5355ad65cec3aa6bfc5d3c62d
ToppCell	wk_15-18-Mesenchymal-Chondrocyte-intermediate_chondrocyte\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	COL9A3 ATP1A2 FZD2 FOXD1	1.57e-04	175	69	4	a84965d28438a4228d841b357c2cd75cf4b59a63
ToppCell	Pericytes-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	KCNA5 ACTC1 ATP1A2 ADGRA2	1.57e-04	175	69	4	ddf721023a7afc8085c5de17aa254a6575444c0f
ToppCell	3'-Child04-06-SmallIntestine-Mesenchymal-Pericytes-Contractile_pericyte_(PLN+)\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	KCNA5 ACTC1 ATP1A2 ADGRA2	1.60e-04	176	69	4	90f36f10c6ed440a0ca549f23219398853f1fbc3
ToppCell	primary_visual_cortex-Non-neuronal-leptomeningeal_cell-VLMC-VLMC_Osr1_Mc5r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TMEM119 FZD2 MUSK FOXD1	1.64e-04	177	69	4	599cf7f5b774e197a1b43c98e4b9a8c1a618f38a
ToppCell	facs-Marrow-B-cells-18m-Hematologic-MPP_Fraction_B_+_C\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A13 TMEM119 ARMCX2 TSPYL4	1.75e-04	180	69	4	7368ab31c3273374ef260f0d710d4eea83cbc4a2
ToppCell	normal_Lung-Myeloid_cells-CD207+CD1a+_LCs\|normal_Lung / Location, Cell class and cell subclass	TCTN3 CRYZ GATA1 SMPD2	1.79e-04	181	69	4	b55dbcfae8c92d322071906831489830a22239b9
ToppCell	normal_Lung-Myeloid_cells-CD207+CD1a+_LCs\|Myeloid_cells / Location, Cell class and cell subclass	TCTN3 CRYZ GATA1 SMPD2	1.82e-04	182	69	4	8dd79fef8f8463ad3194f9cc07c6cacf2c886304
ToppCell	Pericytes-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	KCNA5 ACTA1 ACTC1 ATP1A2	1.86e-04	183	69	4	d04deef7cd4e1738227a6593b84874ce0168c773
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GLI3 FZD2 MUSK FOXD1	1.90e-04	184	69	4	235890e8b424f4386b6ea52d173d20a00898df73
ToppCell	droplet-Kidney-nan-21m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI3 TMEM119 ATP1A2 FZD2	1.94e-04	185	69	4	33cc0e9d8b54cb7408b51235f2a70e044ebae04d
ToppCell	droplet-Spleen-nan-21m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GATA1 MACROD2 CPOX ARMCX1	1.94e-04	185	69	4	239cc5184825b3cc98638d4aec0a1de8e508d76c
ToppCell	droplet-Kidney-nan-21m-Mesenchymal-Stroma____fibroblast\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GLI3 TMEM119 ATP1A2 FZD2	1.94e-04	185	69	4	9954fc85b183c1cc45c3c24e3dadc7984ee6f649
ToppCell	Mid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLI3 PAPLN ATP1A2 ADGRA3	1.98e-04	186	69	4	41e03be964044dae690d566bd078dab3d8045eba
ToppCell	10x5'v1-week_14-16-Mesenchymal_myocytic-stroma-muscle\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ACTA1 ACTC1 TMEM119 CDH4	1.98e-04	186	69	4	b5c1afbe065746ed662527b2f052321f200ba0a8
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLI3 PAPLN ATP1A2 ADGRA3	2.02e-04	187	69	4	dd1d91f101b837bba513f77defa6e6902b2c0570
ToppCell	metastatic_Lymph_Node-Fibroblasts-COL13A1+_matrix_FBs\|metastatic_Lymph_Node / Location, Cell class and cell subclass	PAPLN TMEM119 ADGRA2 MUSK	2.02e-04	187	69	4	e04fb35f2f5b120659d06b5ae427ab1ec56d5c36
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1-6_FGFR3_ETNPPL\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLI3 PAPLN ATP1A2 ADGRA3	2.02e-04	187	69	4	4d2115a05ec36dd179ca1d4a525f2d4501aea557
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLI3 PAPLN ATP1A2 ADGRA3	2.02e-04	187	69	4	ae90c263f80c36a410150d499e268d198944a3d9
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Astro-Astrocyte-Astro_L1_FGFR3_MT1G\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GLI3 PAPLN ATP1A2 ADGRA3	2.02e-04	187	69	4	2b1b2c3792d6c9ab69675ce88842bb589414b530
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRDM8 MACROD2 NKX2-3 ARMCX1	2.02e-04	187	69	4	e1b41560c26795a7d353b9468b1bb6fc7c6b379e
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP1 TMEM119 ATP1A2 ARMCX2	2.11e-04	189	69	4	a5306561026e4dfcc39beeb785e5108ac595d136
ToppCell	facs-Kidney-nan-3m-Mesenchymal\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP1 TMEM119 ATP1A2 ARMCX2	2.11e-04	189	69	4	381058f55908f84375b54601d617389ef43ab855
ToppCell	facs-Kidney-nan-3m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP1 TMEM119 ATP1A2 ARMCX2	2.11e-04	189	69	4	302b950a6ad578f8aeff7ea6fd15fe631225287d
ToppCell	Neuroendocrine-neuroendo-2-Calca\|World / Class top	APLP1 PODXL2 CHKB MEN1	2.11e-04	189	69	4	6baa9a74560121cc008bb8fa9b2b7a335b3aeee0
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNA5 ACTA1 ACTC1 ATP1A2	2.19e-04	191	69	4	d35692c652977500a3c36aa26c347a072b71e441
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNA5 ACTA1 ACTC1 ATP1A2	2.19e-04	191	69	4	2a107e9096eb58b81b3da61547904d85754f6b2f
ToppCell	10x5'v1-week_17-19-Endothelial-stroma-proliferating_EC\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	STAB2 LRFN3 BHMT2 CDH4	2.19e-04	191	69	4	dc9e5eb6aa31b8d79aeec33e59b9138dfb469a3b
ToppCell	Pericytes\|World / lung cells shred on cell class, cell subclass, sample id	KCNA5 ACTC1 ATP1A2 ADGRA2	2.24e-04	192	69	4	057ad22b878c0c5fb59ed1412ca13db945c57a5a
ToppCell	Neuroendocrine\|World / Class top	APLP1 PODXL2 CHKB MEN1	2.24e-04	192	69	4	0199da3ef9ddb6673e9aa41f346f374838aec182
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)\|368C / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 ATP1A2	2.28e-04	193	69	4	5182284dfa7c94027e94172e08f78c86b95d63f4
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 ATP1A2	2.28e-04	193	69	4	5260ac95a15cc43a19909badad0c7e3854da920d
ToppCell	droplet-Lung-30m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17\|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GLI3 PODXL2 ATP1A2 MUSK	2.28e-04	193	69	4	64edc1d6fb0fe117767d494cf4a5723bf8be2804
ToppCell	18-Distal-Mesenchymal-Cartilage\|Distal / Age, Tissue, Lineage and Cell class	COL9A3 SCUBE1 ACTC1 ADGRA3	2.28e-04	193	69	4	52f3d1bb8d8ca91ba12439d46392f377928ff8f8
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 ATP1A2	2.28e-04	193	69	4	5ec917931b438dd0e7fb03eb6af459d3ef6b84ba
ToppCell	368C-Fibroblasts-Fibroblast-K_(Pericytes)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 ATP1A2	2.28e-04	193	69	4	4f7bab0115469c855160636d168bd6e5d4e2dd2f
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 ACTC1 ATP1A2 ADGRA2	2.33e-04	194	69	4	5099e6ad7c19e5f8b73449d904aaefd97f1b1959
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KCNA5 ACTC1 ATP1A2 ADGRA2	2.33e-04	194	69	4	71734ef7b34ab33b349595368176fa0e1175d4d0
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL9A3 MACROD2 APLP1 ARHGEF3	2.42e-04	196	69	4	429de4119c8b2193c992d36a6af84f806730cbee
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCUBE1 KCNA5 ACTA1 ATP1A2	2.42e-04	196	69	4	5159d8625d80c20eb28157b2603c8bde9d377a35
ToppCell	Pericytes\|World / shred by cell class for parenchyma	KCNA5 ACTA1 ACTC1 ATP1A2	2.42e-04	196	69	4	8e7ecbe77d312a7fc6aadd8fd52c13dd1834cc7e
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response-SM_activated_stress_response_L.2.3.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNA5 ACTA1 ACTC1 ATP1A2	2.42e-04	196	69	4	ac4c8571bd792538f8df7b9bdd90ef58405fd3b1
ToppCell	PND28-Mesenchymal\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ACTC1 TMEM119 ATP1A2 FZD2	2.42e-04	196	69	4	119265efd2219f328d8152dbee52af8327aec89c
ToppCell	(08)_PNEC\|World / shred by cell type and Timepoint	APLP1 CHKB TSPYL4 MEN1	2.42e-04	196	69	4	2ee37155c03cd5009427a4bffe6c80ed2ac6939e
ToppCell	5'-GW_trimst-1-SmallIntestine-Mesenchymal-mesothelial_cell-Mesothelium_(RGS5+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	COL9A3 MACROD2 APLP1 ARHGEF3	2.42e-04	196	69	4	8c8a73d9d9581b8d9a9babfa93459d12fb9eb3ac
ToppCell	3'-Broncho-tracheal-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-Fibromyocytes-Fibromyocytes_L.2.3.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SCUBE1 KCNA5 ACTA1 ATP1A2	2.42e-04	196	69	4	6b5b7dbcb2cce8a736e44145a01290905876a5e9
ToppCell	3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-tracheobronchial_smooth_muscle_cell-SM_activated_stress_response\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNA5 ACTA1 ACTC1 ATP1A2	2.42e-04	196	69	4	70b2e0b4ff4f1bc03fb72ace07a8a44f4b415922
ToppCell	P03-Mesenchymal-myocytic_cell\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KCNA5 ACTC1 APLP1 CDH4	2.47e-04	197	69	4	079db904a08743b3c555cb7b3f5fb5c978dde25a
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)\|343B / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 ATP1A2	2.47e-04	197	69	4	78d45d11820ec379942c4c3defd619d5f8cc8e1f
ToppCell	343B-Fibroblasts-Fibroblast-K_(Pericytes)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 ATP1A2	2.47e-04	197	69	4	31bc9fd679d78550541d4158568e8dd09ff29e8e
ToppCell	Parenchymal-10x3prime_v2-Stromal-Myofibroblastic-Muscle_smooth_systemic_arterial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KCNA5 ACTA1 ACTC1 ATP1A2	2.47e-04	197	69	4	470e23dee4ca35e1fd021b7cdd58fcbc90639837
ToppCell	Bronchial-10x5prime-Stromal-Fibroblastic-Fibro_immune_recruiting\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	PAPLN TMEM119 ADGRA2 MUSK	2.56e-04	199	69	4	0cdbedf09ec72734b86ddab3fec562e066afed92
ToppCell	Tracheal-10x3prime_v2-Stromal-Myofibroblastic\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KCNA5 ACTA1 ACTC1 ATP1A2	2.56e-04	199	69	4	534dcfe8b65ad92bb8d749d1c7036ad4807e09cd
ToppCell	390C-Fibroblasts-Fibroblast-K_(Pericytes)-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 PFKP	2.61e-04	200	69	4	2bc7f462a551292de2501028164573935232f899
ToppCell	Macroglial-Astrocytes-SLC14A1---\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GLI3 PAPLN ATP1A2 PFKP	2.61e-04	200	69	4	d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCell	Macroglial-Astrocytes-SLC14A1----L1-6\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GLI3 PAPLN ATP1A2 PFKP	2.61e-04	200	69	4	f861509b54185d89931db64da1b9d81986cc7938
ToppCell	Macroglial-Astrocytes-SLC14A1\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GLI3 PAPLN ATP1A2 PFKP	2.61e-04	200	69	4	16f468217427921fa18c6d078ffa990eb019b257
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	NARF PRDM8 APLP1 PODXL2	2.61e-04	200	69	4	e4f0bb57be1112869c7068d0a789c2b802a442dd
ToppCell	Macroglial-Astrocytes-SLC14A1--\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GLI3 PAPLN ATP1A2 PFKP	2.61e-04	200	69	4	0442894c39eec69850c090957a5dc7bcecd21e04
ToppCell	Macroglial-Astrocytes-SLC14A1-\|Macroglial / cells hierarchy compared to all cells using T-Statistic	GLI3 PAPLN ATP1A2 PFKP	2.61e-04	200	69	4	01819446deeab9054f5cfe889d53bb49d137dbc0
ToppCell	3'-GW_trimst-1-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_2_(ZEB2+)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NKX2-3 TMEM119 ADGRA2 MUSK	2.61e-04	200	69	4	ac8a5d71acd4d401995babd233f0d3738e8ad2a5
ToppCell	390C-Fibroblasts-Fibroblast-K_(Pericytes)\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	KCNA5 ACTA1 ACTC1 PFKP	2.61e-04	200	69	4	8b80a65b69b36ed405214564b939452c90aa40d6
Disease	common bile duct disease (implicated_via_orthology)	SLC25A12 SLC25A13	4.93e-06	2	66	2	DOID:4137 (implicated_via_orthology)
Disease	citrullinemia (implicated_via_orthology)	SLC25A12 SLC25A13	1.48e-05	3	66	2	DOID:9273 (implicated_via_orthology)
Disease	intrahepatic cholestasis (implicated_via_orthology)	SLC25A12 SLC25A13	2.95e-05	4	66	2	DOID:1852 (implicated_via_orthology)
Disease	Moyamoya disease (implicated_via_orthology)	ACTA1 ACTC1	1.37e-04	8	66	2	DOID:13099 (implicated_via_orthology)
Disease	autosomal dominant nonsyndromic deafness 20 (implicated_via_orthology)	ACTA1 ACTC1	1.37e-04	8	66	2	DOID:0110550 (implicated_via_orthology)
Disease	Baraitser-Winter syndrome 1 (implicated_via_orthology)	ACTA1 ACTC1	1.37e-04	8	66	2	DOID:0081112 (implicated_via_orthology)
Disease	thoracic aortic aneurysm (implicated_via_orthology)	ACTA1 ACTC1	1.37e-04	8	66	2	DOID:14004 (implicated_via_orthology)
Disease	intestinal atresia (implicated_via_orthology)	ACTA1 ACTC1	2.19e-04	10	66	2	DOID:10486 (implicated_via_orthology)
Disease	patent ductus arteriosus (implicated_via_orthology)	ACTA1 ACTC1	2.19e-04	10	66	2	DOID:13832 (implicated_via_orthology)
Disease	hearing threshold measurement, hearing measurement	SCUBE1 MACROD2 PFKP	3.51e-04	61	66	3	EFO_0007616, EFO_0007618
Disease	epilepsy (implicated_via_orthology)	KCNA5 SLC13A1 ATP1A2 CHKB	4.95e-04	163	66	4	DOID:1826 (implicated_via_orthology)
Disease	cis/trans-18:2 fatty acid measurement, trans fatty acid measurement	CDH4 MUSK	5.08e-04	15	66	2	EFO_0006821, EFO_0006824
Disease	preeclampsia, hypertension, pregnancy-induced	PRDM8 FURIN	5.79e-04	16	66	2	EFO_0000668, MONDO_0024664
Disease	depressive disorder (is_implicated_in)	HTR1A GATA1	6.56e-04	17	66	2	DOID:1596 (is_implicated_in)
Disease	Disproportionate short stature	TCTN3 COL9A3 GLI3	6.95e-04	77	66	3	C0878659
Disease	alcoholic liver disease	GLI3 MACROD2 ADGRA3	8.34e-04	82	66	3	EFO_0008573
Disease	mean arterial pressure, alcohol drinking	PRDM8 GLI3 FURIN	1.40e-03	98	66	3	EFO_0004329, EFO_0006340
Disease	PCSK9 protein measurement	KCNA5 MUSK	1.55e-03	26	66	2	EFO_0006899
Disease	myeloperoxidase measurement	ACTA1 NUP133	1.55e-03	26	66	2	EFO_0005243
Disease	thrombocytopenia (is_implicated_in)	GATA1 F7	1.67e-03	27	66	2	DOID:1588 (is_implicated_in)
Disease	hypertension (biomarker_via_orthology)	KCNA5 ACTC1 ATP1A2 F7	1.69e-03	227	66	4	DOID:10763 (biomarker_via_orthology)
Disease	ceramide measurement	SLC13A1 MACROD2 MUSK ADGRA3	1.92e-03	235	66	4	EFO_0010222
Disease	arteriosclerosis (is_marker_for)	FURIN F7	1.92e-03	29	66	2	DOID:2349 (is_marker_for)
Disease	factor VIII measurement, coronary artery disease	PRDM8 STAB2 FURIN	2.10e-03	113	66	3	EFO_0001645, EFO_0004630

Protein segments in the cluster

Peptide	Gene	Start	Entry
VVGGCNASFASQGGL	AEBP2	331	Q6ZN18
ACQGAVLGGVGEKSG	COL9A3	666	Q14050
VLCAAGQAGVLDSEG	ARHGEF3	451	Q9NR81
VCDNGSGLVKAGFAG	ACTA1	11	P68133
LAQSQVCEAGAAAGG	ADGRA2	1141	Q96PE1
GAGRAAGAAEGKVVC	ADGRA3	51	Q8IWK6
TAAGAVCLPAGGAGE	C2orf27A	151	P0DPF5
GAAEAPGSAQVAGLC	APLP1	46	P51693
TAVAGSGAVGGCLAK	CHKB	6	Q9Y259
VGASAQGVCGTVGSG	DSC2	761	Q02487
DAGCVAAGIVIGAGA	ARMCX2	6	Q7L311
GCGGEGAAPRQALAA	ANO8	1156	Q9HCE9
AACGGTGCAVLNGEG	RCC1L	341	Q96I51
GASGGVGLAACQIAR	CRYZ	156	Q08257
SGGGCAAQAAVGPAA	FOXD1	406	Q16676
LSGGGTGFVAGNVCV	KRT26	21	Q7Z3Y9
TGFVAGNVCVGSGAR	KRT26	26	Q7Z3Y9
GVAFAVVGACQALGL	MEN1	161	O00255
LVGGAFLGACVAGSD	PODXL2	21	Q9NZ53
AQGDSVLGAGACGGV	NUP133	446	Q8WUM0
GALDGACGAGIQASK	GLI3	1266	P10071
QAVARGAGEAGAAGE	PNMA6F	111	A0A0J9YX94
LGCGGNGLVFSAVDN	MAPK6	26	Q16659
NLCVIGGDGSLTGAN	PFKP	121	Q01813
GQIDGDLLSGVCFVG	FZD2	391	Q14332
GGIFTCIAANAAGEA	LRFN3	361	Q9BTN0
GGEVGTAAAQEKCGA	NKX2-8	186	O15522
GECQLAAVDGGQAGS	NEU4	221	Q8WWR8
LCVLAAGGGAGEAAI	SMPD2	341	O60906
VVAGGSGSGNCGEVA	GATA1	336	P15976
GCQRQGAIVAVTGDG	ATP1A2	701	P50993
EARAGCGQATGGELQ	KCNA5	21	P22460
VAGKGDALVAGGICQ	BHMT2	101	Q9H2M3
VCAGGDGVISACNGD	CTRC	201	Q99895
EVAAVANNGVCGVGV	FURIN	201	P09958
AGGNVVDAGVGAALC	GGT6	121	Q6P531
NGDCTTIGAVAAAGL	CDH4	716	P55283
GVESKAGGALCANGA	HTR1A	266	P08908
AGGALCANGAVRQGD	HTR1A	271	P08908
VEVACNGLLGAGKGS	MAN2C1	146	Q9NTJ4
GCGAGADGVLVVGTT	FIGNL2	521	A6NMB9
GELGQLCQQAAAGAG	FIGNL2	596	A6NMB9
AAGSEGAAGQNCVPV	ETV2	121	O00321
GAAGQNCVPVAGEAT	ETV2	126	O00321
AILVGGGFALADGCE	SLC13A1	436	Q9BZW2
KALEGQGACGAGQVL	SCUBE1	611	Q8IWY4
GGGGISCVLQDGCVF	CPOX	186	P36551
GTAAGAACAQGTLQG	NKX2-3	346	Q8TAU0
DNGLCGAGAEALAGA	LRRC74B	116	Q6ZQY2
EAAGCGRQALGQGGE	ARHGAP30	636	Q7Z6I6
ANASLLGGGGVDGCI	MACROD2	91	A1Z1Q3
GARGSGCQGAAETDA	NKX1-1	221	Q15270
QGCLAAGGVAKASGG	F7	16	P08709
AVKLQGAADLNGGCG	PRDM8	546	Q9NQV8
NTAGALAGVVGVCLG	SLC17A9	376	Q9BYT1
GGGAAEISCALAVSQ	CCT5	421	P48643
CGFANIGSLGIVIGG	SLC28A3	561	Q9HAS3
TGAAAGGGNCRFVES	SMURF1	186	Q9HCE7
VCDNGSGLVKAGFAG	ACTC1	11	P68032
EAGCVAAGVVIGAGA	ARMCX1	6	Q9P291
LPAEVLAGGCAGGSQ	SLC25A12	426	O75746
LAGGCAGGSQVIFTN	SLC25A12	431	O75746
EILAGGCAGGSQVIF	SLC25A13	431	Q9UJS0
EGAGFCGQVALIGDG	PITPNM1	551	O00562
VATAAGPLGEGCVGQ	PAPLN	731	O95428
VGGGIAGVTCAEQLA	PYROXD1	16	Q8WU10
CAIATNGAVQGGGAY	SLC12A9	91	Q9BXP2
AGQKALEACGAGGLG	TSPYL4	126	Q9UJ04
CFGNGICLDGVNGTG	STAB2	1356	Q8WWQ8
LAGGLGVTACAAAGV	TMEM201	16	Q5SNT2
AGVGAGGLCAESNPA	TCTN3	231	Q6NUS6
CSGVLEGAVVAGEGQ	TMEM119	236	Q4V9L6
SGAAGACGSVAGQIG	PTGR2	161	Q8N8N7
VLACAGGCLNGRGQA	NARF	371	Q9UHQ1
ANNGVGGAVESCGAL	MUSK	101	O15146