Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioncalcium ion binding

JAG2 SLIT2 EYS NOTCH2NLB CELSR3 CELSR2 MEGF8 NRXN1 LRP4 LTBP1 LTBP2 PLSCR3 CUBN LRP1B TENM2 NOTCH2 NOTCH4 CRB2

6.39e-097499118GO:0005509
GeneOntologyMolecularFunctionextracellular matrix binding

TINAGL1 SLIT2 LTBP1 LTBP2 ITGB3 CTSS

1.01e-0673916GO:0050840
GeneOntologyMolecularFunctionneuroligin family protein binding

NRXN3 NRXN1

2.04e-045912GO:0097109
GeneOntologyMolecularFunctionNotch binding

JAG2 NOTCH2NLB NOTCH4

2.47e-0427913GO:0005112
GeneOntologyMolecularFunctionmicrofibril binding

LTBP1 LTBP2

3.04e-046912GO:0050436
GeneOntologyMolecularFunctionpolysaccharide binding

CLEC18A CLEC18B CLEC18C

3.75e-0431913GO:0030247
GeneOntologyMolecularFunctionlaminin binding

TINAGL1 SLIT2 CTSS

4.95e-0434913GO:0043236
GeneOntologyMolecularFunctionintegrin binding

ADAM23 TNR ITGB3 ITGB6 ITGB8

1.24e-03175915GO:0005178
GeneOntologyMolecularFunctionsodium:phosphate symporter activity

SLC17A2 SLC17A1

1.32e-0312912GO:0005436
GeneOntologyBiologicalProcessaxon guidance

SLIT2 NRXN3 CELSR3 MEGF8 NRXN1 TNR TENM2 NOTCH2 USP33

3.91e-06285899GO:0007411
GeneOntologyBiologicalProcessneuron projection guidance

SLIT2 NRXN3 CELSR3 MEGF8 NRXN1 TNR TENM2 NOTCH2 USP33

4.03e-06286899GO:0097485
GeneOntologyBiologicalProcesscell morphogenesis involved in neuron differentiation

SLIT2 NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 TECTA PLXNB2 TNR TENM2 NOTCH2 USP33

1.87e-057488913GO:0048667
GeneOntologyBiologicalProcessaxon development

SLIT2 NRXN3 CELSR3 MEGF8 NRXN1 LRP4 GRN PLXNB2 TNR TENM2 NOTCH2 USP33

1.99e-056428912GO:0061564
GeneOntologyBiologicalProcessaxonogenesis

SLIT2 NRXN3 CELSR3 MEGF8 NRXN1 LRP4 PLXNB2 TNR TENM2 NOTCH2 USP33

3.18e-055668911GO:0007409
GeneOntologyBiologicalProcessneuron cell-cell adhesion

NRXN3 NRXN1 TNR

4.18e-0516893GO:0007158
GeneOntologyBiologicalProcesscell morphogenesis

SLIT2 NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 TECTA PLXNB2 TNR ITGB3 TENM2 ITGB6 NOTCH2 NOTCH4 USP33

4.63e-0511948916GO:0000902
GeneOntologyBiologicalProcesscell projection morphogenesis

SLIT2 NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 PLXNB2 TNR ITGB3 TENM2 NOTCH2 USP33

5.23e-058268913GO:0048858
GeneOntologyBiologicalProcesscellular response to growth factor stimulus

TRIM33 SLIT2 MEGF8 NRXN1 FBXW7-AS1 LTBP1 LTBP2 GDF9 ITGB3 ITGB6 ITGB8 NOTCH2 CRB2

7.00e-058508913GO:0071363
GeneOntologyBiologicalProcessresponse to growth factor

TRIM33 SLIT2 MEGF8 NRXN1 FBXW7-AS1 LTBP1 LTBP2 GDF9 ITGB3 ITGB6 ITGB8 NOTCH2 CRB2

1.03e-048838913GO:0070848
GeneOntologyBiologicalProcessLangerhans cell differentiation

ITGB6 ITGB8

1.10e-044892GO:0061520
GeneOntologyBiologicalProcesstransforming growth factor beta receptor superfamily signaling pathway

TRIM33 MEGF8 LTBP1 LTBP2 GDF9 ITGB6 ITGB8 NOTCH2 CRB2

1.29e-04445899GO:0141091
GeneOntologyBiologicalProcessneuron projection morphogenesis

SLIT2 NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 PLXNB2 TNR TENM2 NOTCH2 USP33

1.67e-048028912GO:0048812
GeneOntologyBiologicalProcesscell-cell adhesion

SLIT2 NRXN3 RASAL3 CELSR3 CELSR2 NRXN1 PLXNB2 TNR ITGB3 TENM2 ITGB6 ITGB8 NOTCH4 CRB2

2.01e-0410778914GO:0098609
GeneOntologyBiologicalProcessplasma membrane bounded cell projection morphogenesis

SLIT2 NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 PLXNB2 TNR TENM2 NOTCH2 USP33

2.03e-048198912GO:0120039
GeneOntologyBiologicalProcesssecondary palate development

JAG2 ITGB6 ITGB8

2.11e-0427893GO:0062009
GeneOntologyBiologicalProcesscell surface receptor protein serine/threonine kinase signaling pathway

TRIM33 MEGF8 LTBP1 LTBP2 GDF9 ITGB6 ITGB8 NOTCH2 CRB2

2.34e-04482899GO:0007178
GeneOntologyBiologicalProcessmyeloid dendritic cell differentiation

ITGB6 ITGB8 NOTCH2

2.35e-0428893GO:0043011
GeneOntologyBiologicalProcessneuron projection development

SLIT2 NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 GRN TECTA PLXNB2 TNR TENM2 VPS13B NOTCH2 USP33

3.72e-0412858915GO:0031175
GeneOntologyBiologicalProcesssynapse assembly

GABRG1 SLIT2 NRXN3 HTR4 NRXN1 LRP4 PLXNB2

3.74e-04308897GO:0007416
GeneOntologyBiologicalProcessneuron development

SLIT2 NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 GRN TECTA PLXNB2 TNR TENM2 VPS13B NOTCH2 CRB2 USP33

4.78e-0414638916GO:0048666
GeneOntologyBiologicalProcesschordate embryonic development

JAG2 HINFP PCSK5 SLIT2 MEGF8 GRN CUBN PLXNB2 LRP1B NCAPG2 NOTCH2 CRB2

5.06e-049068912GO:0043009
GeneOntologyBiologicalProcessmulticellular organismal-level homeostasis

SLC12A3 HTR4 TLE3 SIVA1 CUBN ITGB3 NCAPG2 ITGB6 CTSS VPS13B PLAC8 CRB2 TFF2

5.18e-0410438913GO:0048871
GeneOntologyBiologicalProcessdevelopmental growth

SLIT2 EYS MEGF8 ATRX LRP4 GRN GDF9 TNR NCAPG2 VPS13B PLAC8 NOTCH2

5.31e-049118912GO:0048589
GeneOntologyBiologicalProcessenzyme-linked receptor protein signaling pathway

TRIM33 MEGF8 NRXN1 PDGFRL LRP4 FBXW7-AS1 LTBP1 LTBP2 GDF9 ITGB3 ITGB6 ITGB8 NOTCH2 CRB2

5.34e-0411868914GO:0007167
GeneOntologyBiologicalProcessanatomical structure homeostasis

HTR4 CUBN ITGB3 CTSS VPS13B CRB2 TFF2

6.07e-04334897GO:0060249
GeneOntologyBiologicalProcesstissue homeostasis

HTR4 CUBN ITGB3 CTSS VPS13B CRB2 TFF2

6.07e-04334897GO:0001894
GeneOntologyBiologicalProcessembryo development ending in birth or egg hatching

JAG2 HINFP PCSK5 SLIT2 MEGF8 GRN CUBN PLXNB2 LRP1B NCAPG2 NOTCH2 CRB2

6.32e-049298912GO:0009792
GeneOntologyBiologicalProcessblood vessel development

PCSK5 SLIT2 NRXN3 MEGF8 NRXN1 APOLD1 GRN LTBP1 ITGB3 ITGB8 NOTCH2 NOTCH4

6.32e-049298912GO:0001568
GeneOntologyBiologicalProcessmaintenance of synapse structure

NRXN1 GRN ITGB3

6.84e-0440893GO:0099558
GeneOntologyBiologicalProcesspostsynapse assembly

NRXN3 HTR4 NRXN1 LRP4

7.06e-0493894GO:0099068
GeneOntologyBiologicalProcesssynapse organization

GABRG1 SLIT2 NRXN3 HTR4 NRXN1 LRP4 GRN PLXNB2 TNR ITGB3

7.32e-046858910GO:0050808
GeneOntologyCellularComponentprotein complex involved in cell adhesion

NRXN1 TNR ITGB3 ITGB6 ITGB8

5.51e-0659905GO:0098636
GeneOntologyCellularComponentcell surface

SLIT2 SIGLEC7 NRXN1 MRGPRX1 LRP4 CLDND1 SCART1 CUBN PLXNB2 TNR ITGB3 ITGB6 ITGB8 CTSS NOTCH2 NOTCH4

1.90e-0511119016GO:0009986
GeneOntologyCellularComponentintegrin complex

ITGB3 ITGB6 ITGB8

3.50e-0432903GO:0008305
DomainEGF

JAG2 PCSK5 SLIT2 CNTNAP3B CLEC18A HGFAC EYS NRXN3 CELSR3 CELSR2 CLEC18B MEGF8 NRXN1 ADAM23 CNTNAP3 LRP4 CLEC18C LTBP1 LTBP2 CUBN TECTA TNR LRP1B TENM2 ITGB8 NOTCH2 NOTCH4 CRB2

2.15e-322358628SM00181
DomainEGF_1

JAG2 SLIT2 CNTNAP3B CLEC18A HGFAC EYS NRXN3 CELSR3 CELSR2 CLEC18B MEGF8 NRXN1 ADAM23 CNTNAP3 LRP4 CLEC18C LTBP1 LTBP2 CUBN TNR LRP1B ITGB3 TENM2 ITGB6 ITGB8 NOTCH2 NOTCH4 CRB2

2.28e-312558628PS00022
DomainEGF_2

JAG2 SLIT2 CNTNAP3B CLEC18A HGFAC EYS NRXN3 CELSR3 CELSR2 CLEC18B MEGF8 NRXN1 ADAM23 CNTNAP3 LRP4 CLEC18C LTBP1 LTBP2 CUBN TNR LRP1B ITGB3 TENM2 ITGB6 ITGB8 NOTCH2 NOTCH4 CRB2

6.90e-312658628PS01186
DomainEGF-like_dom

JAG2 PCSK5 SLIT2 CNTNAP3B CLEC18A HGFAC EYS NRXN3 CELSR3 CELSR2 CLEC18B MEGF8 NRXN1 ADAM23 CNTNAP3 LRP4 CLEC18C LTBP1 LTBP2 CUBN TECTA TNR LRP1B TENM2 NOTCH2 NOTCH4 CRB2

4.51e-302498627IPR000742
DomainEGF-like_CS

JAG2 SLIT2 CLEC18A HGFAC EYS NRXN3 CELSR3 CELSR2 CLEC18B MEGF8 NRXN1 ADAM23 CNTNAP3 LRP4 CLEC18C LTBP1 LTBP2 CUBN TNR LRP1B ITGB3 TENM2 ITGB6 ITGB8 NOTCH2 NOTCH4 CRB2

1.66e-292618627IPR013032
DomainEGF_3

JAG2 SLIT2 CNTNAP3B CLEC18A HGFAC EYS NRXN3 CELSR3 CELSR2 CLEC18B MEGF8 NRXN1 ADAM23 CNTNAP3 LRP4 CLEC18C LTBP1 LTBP2 CUBN TNR LRP1B TENM2 NOTCH2 NOTCH4 CRB2

1.34e-272358625PS50026
DomainEGF

JAG2 SLIT2 HGFAC EYS NRXN3 CELSR3 CELSR2 NRXN1 CNTNAP3 LRP4 LTBP1 LTBP2 CUBN TECTA LRP1B ITGB3 NOTCH2 NOTCH4 CRB2

5.17e-241268619PF00008
DomainASX_HYDROXYL

JAG2 SLIT2 EYS NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 LTBP1 LTBP2 CUBN LRP1B NOTCH2 NOTCH4 CRB2

9.28e-211008616PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

JAG2 SLIT2 EYS NRXN3 CELSR3 CELSR2 MEGF8 NRXN1 LRP4 LTBP1 LTBP2 CUBN LRP1B NOTCH2 NOTCH4 CRB2

2.49e-201068616IPR000152
DomainEGF_CA

JAG2 SLIT2 EYS CELSR3 CELSR2 MEGF8 LRP4 LTBP1 LTBP2 CUBN LRP1B TENM2 NOTCH2 NOTCH4 CRB2

1.02e-171228615SM00179
DomainEGF-like_Ca-bd_dom

JAG2 SLIT2 EYS CELSR3 CELSR2 MEGF8 LRP4 LTBP1 LTBP2 CUBN LRP1B TENM2 NOTCH2 NOTCH4 CRB2

1.32e-171248615IPR001881
DomainEGF_Ca-bd_CS

JAG2 SLIT2 EYS MEGF8 LRP4 LTBP1 LTBP2 CUBN LRP1B NOTCH2 NOTCH4 CRB2

2.13e-14978612IPR018097
DomainEGF_CA

JAG2 SLIT2 EYS MEGF8 LRP4 LTBP1 LTBP2 CUBN LRP1B NOTCH2 NOTCH4 CRB2

2.74e-14998612PS01187
DomainLAM_G_DOMAIN

SLIT2 CNTNAP3B EYS NRXN3 CELSR3 CELSR2 NRXN1 CNTNAP3 CRB2

8.85e-1438869PS50025
DomainLaminin_G_2

SLIT2 CNTNAP3B EYS NRXN3 CELSR3 CELSR2 NRXN1 CNTNAP3 CRB2

1.47e-1340869PF02210
DomainGrowth_fac_rcpt_

JAG2 PCSK5 EYS CELSR2 MEGF8 ELAPOR1 LRP4 LTBP1 LTBP2 CUBN LRP1B NOTCH2 NOTCH4

2.99e-131568613IPR009030
DomainLamG

SLIT2 CNTNAP3B EYS NRXN3 CELSR3 CELSR2 NRXN1 CNTNAP3 CRB2

3.76e-1344869SM00282
DomainLaminin_G

SLIT2 CNTNAP3B EYS NRXN3 CELSR3 CELSR2 NRXN1 CNTNAP3 CRB2

5.37e-1258869IPR001791
DomainhEGF

JAG2 SLIT2 EYS CELSR2 NOTCH2 NOTCH4 CRB2

3.75e-1128867PF12661
DomainEGF_CA

JAG2 MEGF8 LRP4 LTBP1 LTBP2 CUBN LRP1B NOTCH2 NOTCH4

2.09e-1086869PF07645
DomainEGF_extracell

JAG2 ADAM23 LTBP2 TNR LRP1B ITGB3 ITGB6 ITGB8

3.05e-1060868IPR013111
DomainEGF_2

JAG2 ADAM23 LTBP2 TNR LRP1B ITGB3 ITGB6 ITGB8

3.05e-1060868PF07974
Domain-

SLIT2 EYS NRXN3 CELSR3 CELSR2 NRXN1 CNTNAP3 CRB2

1.27e-08958682.60.120.200
DomainIntegin_beta_N

MEGF8 ITGB3 ITGB6 ITGB8

5.19e-089864IPR033760
DomainPSI_integrin

MEGF8 ITGB3 ITGB6 ITGB8

5.19e-089864PF17205
DomainConA-like_dom

SLIT2 CNTNAP3B EYS NRXN3 CELSR3 CELSR2 NRXN1 CNTNAP3 CRB2

7.48e-07219869IPR013320
DomainPSI

MEGF8 PLXNB2 ITGB3 ITGB6 ITGB8

1.74e-0644865IPR016201
DomainPSI

MEGF8 PLXNB2 ITGB3 ITGB6 ITGB8

2.17e-0646865SM00423
DomainIntegrin_beta

ITGB3 ITGB6 ITGB8

5.19e-068863PF00362
DomainINB

ITGB3 ITGB6 ITGB8

5.19e-068863SM00187
DomainIntegrin_bsu_VWA

ITGB3 ITGB6 ITGB8

5.19e-068863IPR002369
DomainIntegrin_bsu

ITGB3 ITGB6 ITGB8

7.76e-069863IPR015812
DomainINTEGRIN_BETA

ITGB3 ITGB6 ITGB8

7.76e-069863PS00243
Domain-

CLEC18A CLEC18B CLEC18C

4.12e-05158633.40.33.10
DomainCAP

CLEC18A CLEC18B CLEC18C

4.12e-0515863PF00188
DomainCAP_domain

CLEC18A CLEC18B CLEC18C

4.12e-0515863IPR014044
DomainSCP

CLEC18A CLEC18B CLEC18C

4.12e-0515863SM00198
DomainAllrgn_V5/Tpx1

CLEC18A CLEC18B CLEC18C

4.12e-0515863IPR001283
DomainNotch

NOTCH2 NOTCH4

1.25e-044862IPR008297
DomainNODP

NOTCH2 NOTCH4

1.25e-044862PF07684
DomainNotch_NODP_dom

NOTCH2 NOTCH4

1.25e-044862IPR011656
DomainNotch_NOD_dom

NOTCH2 NOTCH4

1.25e-044862IPR010660
DomainNOD

NOTCH2 NOTCH4

1.25e-044862PF06816
Domain-

ITGB3 ITGB6

1.25e-0448621.20.5.630
DomainNOD

NOTCH2 NOTCH4

1.25e-044862SM01338
DomainNODP

NOTCH2 NOTCH4

1.25e-044862SM01339
DomainEphrin_rec_like

PCSK5 ELAPOR1 TG

2.01e-0425863SM01411
DomainIntegrin_dom

ITGB3 ITGB6 ITGB8

2.01e-0425863IPR032695
DomainTyr-kin_ephrin_A/B_rcpt-like

PCSK5 ELAPOR1 TG

2.01e-0425863IPR011641
DomainGroucho_enhance

TLE3 TLE4

2.08e-045862IPR009146
DomainTLE_N

TLE3 TLE4

2.08e-045862PF03920
DomainLNR

NOTCH2 NOTCH4

2.08e-045862PS50258
DomainGroucho/TLE_N

TLE3 TLE4

2.08e-045862IPR005617
DomaincEGF

LRP4 LTBP1 LRP1B

2.27e-0426863IPR026823
DomaincEGF

LRP4 LTBP1 LRP1B

2.27e-0426863PF12662
DomainIntegrin_bsu_cyt_dom

ITGB3 ITGB6

3.11e-046862IPR014836
DomainIntegrin_b_cyt

ITGB3 ITGB6

3.11e-046862SM01241
DomainIntegrin_b_cyt

ITGB3 ITGB6

3.11e-046862PF08725
DomainEGF_LAM_2

CELSR3 CELSR2 MEGF8

3.50e-0430863PS50027
DomainEGF_LAM_1

CELSR3 CELSR2 MEGF8

3.50e-0430863PS01248
DomainFIBRINOGEN_C_1

CNTNAP3B CNTNAP3 TNR

4.25e-0432863PS00514
DomainFibrinogen_a/b/g_C_dom

CNTNAP3B CNTNAP3 TNR

4.25e-0432863IPR002181
DomainFIBRINOGEN_C_2

CNTNAP3B CNTNAP3 TNR

4.25e-0432863PS51406
DomainIntegrin_bsu_tail

ITGB3 ITGB6

4.34e-047862IPR012896
DomainTB

LTBP1 LTBP2

4.34e-047862PF00683
DomainNotch_dom

NOTCH2 NOTCH4

4.34e-047862IPR000800
DomainSyndecan

NRXN3 NRXN1

4.34e-047862PF01034
DomainNotch

NOTCH2 NOTCH4

4.34e-047862PF00066
DomainSyndecan/Neurexin_dom

NRXN3 NRXN1

4.34e-047862IPR027789
DomainIntegrin_B_tail

ITGB3 ITGB6

4.34e-047862SM01242
DomainNL

NOTCH2 NOTCH4

4.34e-047862SM00004
DomainIntegrin_B_tail

ITGB3 ITGB6

4.34e-047862PF07965
DomainLaminin_EGF

CELSR3 CELSR2 MEGF8

5.55e-0435863PF00053
DomainEGF_Lam

CELSR3 CELSR2 MEGF8

5.55e-0435863SM00180
Domain-

LTBP1 LTBP2

5.76e-0488623.90.290.10
DomainLaminin_EGF

CELSR3 CELSR2 MEGF8

7.08e-0438863IPR002049
DomainTB

LTBP1 LTBP2

7.39e-049862PS51364
DomainTB_dom

LTBP1 LTBP2

7.39e-049862IPR017878
Domain-

LRP4 LRP1B TENM2

7.64e-04398632.120.10.30
DomainZnf_RING

TRIM33 ATRX ANKIB1 NFXL1 BIRC2 RNF122 RNF170

7.65e-04326867IPR001841
DomainC-type_lectin_CS

CLEC18A CLEC18B CLEC18C

1.02e-0343863IPR018378
DomainPept_his_AS

TINAGL1 CTSS

1.12e-0311862IPR025660
DomainGAIN_dom_N

CELSR3 CELSR2

1.12e-0311862IPR032471
DomainLaminin_G_1

SLIT2 EYS

1.12e-0311862PF00054
DomainGAIN

CELSR3 CELSR2

1.12e-0311862PF16489
Domain6-blade_b-propeller_TolB-like

LRP4 LRP1B TENM2

1.24e-0346863IPR011042
DomainEGF_3

MEGF8 CUBN

1.34e-0312862PF12947
DomainEGF_dom

MEGF8 CUBN

1.34e-0312862IPR024731
DomainPept_C1

TINAGL1 CTSS

1.58e-0313862SM00645
DomainPeptidase_C1A_C

TINAGL1 CTSS

1.58e-0313862IPR000668
DomainPeptidase_C1

TINAGL1 CTSS

1.58e-0313862PF00112
DomainPeptidase_C1A

TINAGL1 CTSS

1.58e-0313862IPR013128
DomainLdl_recept_b

LRP4 LRP1B

1.84e-0314862PF00058
DomainLDLRB

LRP4 LRP1B

1.84e-0314862PS51120
DomainNeurexin-like

NRXN3 NRXN1

1.84e-0314862IPR003585
Domain4.1m

NRXN3 NRXN1

1.84e-0314862SM00294
DomainLY

LRP4 LRP1B

2.12e-0315862SM00135
DomainLDLR_classB_rpt

LRP4 LRP1B

2.12e-0315862IPR000033
DomainZF_RING_1

TRIM33 ANKIB1 NFXL1 BIRC2 RNF122 RNF170

2.25e-03291866PS00518
Domain-

RASAL3 PLXNB2

2.41e-03168621.10.506.10
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

2.57e-0732625MM14854
PathwayREACTOME_MOLECULES_ASSOCIATED_WITH_ELASTIC_FIBRES

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

5.46e-0737625M27134
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

6.27e-0738625MM14874
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

7.17e-0739625MM14601
PathwayREACTOME_ELASTIC_FIBRE_FORMATION

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

1.33e-0644625M26969
PathwayREACTOME_TGF_BETA_RECEPTOR_SIGNALING_ACTIVATES_SMADS

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

1.86e-0647625M646
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

TRIM33 LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

3.41e-0694626M1041
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

NRXN1 LRP4 LTBP1 LTBP2 TNR ITGB3 ITGB6 ITGB8 CTSS

5.99e-06300629M610
PathwayREACTOME_SIGNALING_BY_TGF_BETA_RECEPTOR_COMPLEX

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

2.16e-0577625MM14670
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH2 NOTCH4

2.25e-0513623M47423
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

TRIM33 LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

7.33e-05161626M27871
PathwayREACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION

LTBP1 LTBP2 TNR ITGB3 ITGB6 ITGB8 CTSS

1.32e-04258627MM14572
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOGAP_RHOA_SIGNALING_PATHWAY

ITGB3 ITGB6 ITGB8

1.35e-0423623M47537
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOGEF_RHOA_SIGNALING_PATHWAY

ITGB3 ITGB6 ITGB8

1.35e-0423623M47720
PathwayREACTOME_SIGNALING_BY_TGFB_FAMILY_MEMBERS

LTBP1 LTBP2 ITGB3 ITGB6 ITGB8

1.67e-04118625MM15588
PathwayREACTOME_DEFECTIVE_LFNG_CAUSES_SCDO3

NOTCH2 NOTCH4

1.89e-045622M27411
PathwayPID_INTEGRIN_CS_PATHWAY

ITGB3 ITGB6 ITGB8

1.96e-0426623M47
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_FAK_CDC42_SIGNALING_PATHWAY

ITGB3 ITGB6 ITGB8

1.96e-0426623M47719
PathwayWP_CANONICAL_AND_NONCANONICAL_NOTCH_SIGNALING

JAG2 NOTCH2 NOTCH4

2.20e-0427623M39545
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_RHOG_RAC_SIGNALING_PATHWAY

ITGB3 ITGB6 ITGB8

2.45e-0428623M47655
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_THE_ENDOPLASMIC_RETICULUM

NOTCH2 NOTCH4

2.82e-046622M27068
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_TALIN_VINCULIN_SIGNALING_PATHWAY

ITGB3 ITGB6 ITGB8

3.02e-0430623M47724
PathwayKEGG_MEDICUS_REFERENCE_ITGA_B_FAK_RAC_SIGNALING_PATHWAY

ITGB3 ITGB6 ITGB8

3.02e-0430623M47718
PathwayREACTOME_ECM_PROTEOGLYCANS

LRP4 TNR ITGB3 ITGB6

3.43e-0476624M27219
PathwayREACTOME_REGULATION_OF_EXPRESSION_OF_SLITS_AND_ROBOS

SLIT2 USP33

3.94e-047622MM15593
PathwayKEGG_ECM_RECEPTOR_INTERACTION

TNR ITGB3 ITGB6 ITGB8

5.03e-0484624M7098
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE3 TLE4

8.37e-0410622MM15156
PathwayWP_NOTCH_SIGNALING_WP268

JAG2 NOTCH2 NOTCH4

1.01e-0345623M39571
PathwayKEGG_MEDICUS_REFERENCE_NOTCH_PROTEOLYTIC_ACTIVATION

NOTCH2 NOTCH4

1.02e-0311622M47865
PathwayWP_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH2 NOTCH4

1.07e-0346623MM15971
PathwayWP_ADHD_AND_AUTISM_ASD_PATHWAYS

GABRG1 NRXN3 HTR4 NRXN1 SCN9A CNTNAP3 CUBN

1.10e-03367627M48346
PathwayREACTOME_ECM_PROTEOGLYCANS

TNR ITGB3 ITGB6

1.14e-0347623MM14925
PathwayKEGG_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH2 NOTCH4

1.14e-0347623M7946
PathwayWP_MECHANOREGULATION_AND_PATHOLOGY_OF_YAPTAZ_VIA_HIPPO_AND_NONHIPPO_MECHANISMS

ITGB3 ITGB6 ITGB8

1.14e-0347623M39829
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00380

NOTCH2 NOTCH4

1.22e-0312622M47532
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00381

NOTCH2 NOTCH4

1.22e-0312622M47533
PathwayWP_FOCAL_ADHESION

BIRC2 TNR ITGB3 ITGB6 ITGB8

1.37e-03187625MM15913
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E6_TO_NOTCH_SIGNALING_PATHWAY_N00382

NOTCH2 NOTCH4

1.44e-0313622M47534
PathwayWP_OSTEOBLAST_SIGNALING

SLC17A2 ITGB3

1.67e-0314622M39599
PathwayREACTOME_REPRESSION_OF_WNT_TARGET_GENES

TLE3 TLE4

1.67e-0314622M27402
PathwayWP_FOCAL_ADHESION

BIRC2 TNR ITGB3 ITGB6 ITGB8

1.80e-03199625M39402
PathwayKEGG_FOCAL_ADHESION

BIRC2 TNR ITGB3 ITGB6 ITGB8

1.80e-03199625M7253
PathwayKEGG_MEDICUS_VARIANT_NOTCH_OVEREXPRESSION_TO_NOTCH_SIGNALING_PATHWAY

JAG2 NOTCH4

2.20e-0316622M47424
PathwayPID_NOTCH_PATHWAY

JAG2 NOTCH2 NOTCH4

2.21e-0359623M17
PathwayWP_NOTCH_SIGNALING_WP61

JAG2 NOTCH2 NOTCH4

2.43e-0361623M39540
PathwayPID_INTEGRIN5_PATHWAY

ITGB6 ITGB8

2.48e-0317622M212
PathwayREACTOME_PRE_NOTCH_PROCESSING_IN_GOLGI

NOTCH2 NOTCH4

2.78e-0318622M614
PathwayREACTOME_NOTCH4_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION

NOTCH2 NOTCH4

3.44e-0320622M27881
PathwayREACTOME_SIGNALING_BY_ROBO_RECEPTORS

SLIT2 USP33

3.44e-0320622MM14974
PathwayREACTOME_NOTCH2_ACTIVATION_AND_TRANSMISSION_OF_SIGNAL_TO_THE_NUCLEUS

JAG2 NOTCH2

4.15e-0322622M27210
PathwayWP_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY

ITGB3 ITGB6 ITGB8

4.21e-0374623M39462
PathwayKEGG_ARRHYTHMOGENIC_RIGHT_VENTRICULAR_CARDIOMYOPATHY_ARVC

ITGB3 ITGB6 ITGB8

4.21e-0374623M16376
PathwayREACTOME_SIGNALING_BY_NOTCH1

JAG2 TLE3 TLE4

4.21e-0374623M616
PathwayREACTOME_SIGNALING_BY_NOTCH

JAG2 TLE3 TLE4 NOTCH2 NOTCH4

4.48e-03246625M10189
PathwayREACTOME_INTEGRIN_CELL_SURFACE_INTERACTIONS

ITGB3 ITGB6 ITGB8

4.53e-0376623MM14867
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

TINAGL1 CLEC18A HGFAC SIGLEC7 CLEC18B RETNLB ELAPOR1 CLEC18C IGFL2 SHISA4 SLURP2 DKK2

3.93e-09460931220562862
Pubmed

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening.

CELSR3 CELSR2 MEGF8 LRP4

5.97e-0999349693030
Pubmed

Coexpression of Cux-1 and Notch signaling pathway components during kidney development.

TLE3 TLE4 NOTCH2 NOTCH4

1.56e-081193415499562
Pubmed

Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.

CLEC18A CLEC18B CLEC18C

1.85e-08393326170455
Pubmed

The C-type lectin-like domain superfamily.

CLEC18A CLEC18B CLEC18C

1.85e-08393316336259
Pubmed

Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.

CLEC18A CLEC18B CLEC18C

1.85e-08393333603190
Pubmed

Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway.

JAG2 TLE3 TLE4 NOTCH2

6.39e-08159349291577
Pubmed

The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.

CLEC18A CLEC18B CLEC18C

7.39e-08493316709836
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

JAG2 PPP2R2A CELSR3 CELSR2 MEGF8 CNTNAP3 LRP4 GRN LTBP1 LTBP2 PLXNB2 LRP1B NCAPG2 ITGB8 NOTCH2 RNF170

1.16e-071201931635696571
Pubmed

Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins.

TLE3 TLE4 NOTCH2

1.84e-0759331303260
Pubmed

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

ITGB3 ITGB6 ITGB8

3.68e-07693324216753
Pubmed

Identification of candidate lung cancer susceptibility genes in mouse using oligonucleotide arrays.

HTR4 GRN SPOP PPIH NOTCH4

5.02e-075893512205107
Pubmed

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier.

JAG2 SLIT2 ITGB3 ITGB8 NOTCH4

5.48e-075993521421844
Pubmed

Human ligands of the Notch receptor.

JAG2 NOTCH2 NOTCH4

6.43e-07793310079256
Pubmed

The distribution of Notch receptors and their ligands during articular cartilage development.

JAG2 NOTCH2 NOTCH4

6.43e-07793312846471
Pubmed

Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear.

JAG2 NOTCH2 NOTCH4

1.03e-0689339858718
Pubmed

Notch signaling regulates ovarian follicle formation and coordinates follicular growth.

JAG2 GDF9 NOTCH2 NOTCH4

1.24e-063093424552588
Pubmed

Dynamic expression patterns of the pudgy/spondylocostal dysostosis gene Dll3 in the developing nervous system.

JAG2 NOTCH2 NOTCH4

1.54e-06993311118901
Pubmed

Notch1 signals through Jagged2 to regulate apoptosis in the apical ectodermal ridge of the developing limb bud.

JAG2 NOTCH2 NOTCH4

1.54e-06993316245338
Pubmed

Spatiotemporal expression of Notch receptors and ligands in developing mouse placenta.

JAG2 NOTCH2 NOTCH4

2.19e-061093323665443
Pubmed

Jag2-Notch1 signaling regulates oral epithelial differentiation and palate development.

JAG2 NOTCH2 NOTCH4

3.01e-061193316607638
Pubmed

Localisation of members of the notch system and the differentiation of vibrissa hair follicles: receptors, ligands, and fringe modulators.

JAG2 NOTCH2 NOTCH4

3.01e-061193310878608
Pubmed

Notch-associated gene expression in embryonic and adult taste papillae and taste buds suggests a role in taste cell lineage decisions.

JAG2 NOTCH2 NOTCH4

3.01e-061193312866128
Pubmed

Developmental expression of the Notch signaling pathway genes during mouse preimplantation development.

JAG2 NOTCH2 NOTCH4

4.00e-061293315465494
Pubmed

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2.

JAG2 NOTCH2 NOTCH4 TFF2

4.50e-064193422675208
Pubmed

Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

JAG2 NOTCH2 NOTCH4

5.19e-061393311578869
Pubmed

Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway.

JAG2 NOTCH2 NOTCH4

6.60e-061493314757642
Pubmed

Latent transforming growth factor-β binding proteins (LTBP-1 and LTBP-2) and gingiva keratinization.

LTBP1 LTBP2

7.07e-06293225858550
Pubmed

The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice.

CNTNAP3B CNTNAP3

7.07e-06293231150793
Pubmed

Receptor-binding domain of SARS-CoV-2 is a functional αv-integrin agonist.

ITGB3 ITGB6

7.07e-06293236669646
Pubmed

Notch receptors and hematopoiesis.

NOTCH2 NOTCH4

7.07e-06293211532344
Pubmed

Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8.

ITGB6 ITGB8

7.07e-06293219920174
Pubmed

Neurexin-3 subsynaptic densities are spatially distinct from Neurexin-1 and essential for excitatory synapse nanoscale organization in the hippocampus.

NRXN3 NRXN1

7.07e-06293237543682
Pubmed

Neurexin I alpha is a major alpha-latrotoxin receptor that cooperates in alpha-latrotoxin action.

NRXN3 NRXN1

7.07e-0629329430716
Pubmed

Gro/TLE enables embryonic stem cell differentiation by repressing pluripotent gene expression.

TLE3 TLE4

7.07e-06293225446531
Pubmed

TLE3 and TLE4-coordinated colonic macrophage-CD4+ T cell crosstalk maintains intestinal immune homeostasis.

TLE3 TLE4

7.07e-06293236801171
Pubmed

Expression of integrin cell adhesion receptors during human airway epithelial repair in vivo.

ITGB6 ITGB8

7.07e-0629329252563
Pubmed

ADAM23 is downregulated in side population and suppresses lung metastasis of lung carcinoma cells.

ADAM23 ITGB3

7.07e-06293226800504
Pubmed

Chromosomal localization of Celsr2 and Celsr3 in the mouse; Celsr3 is a candidate for the tippy (tip) lethal mutant on chromosome 9.

CELSR3 CELSR2

7.07e-06293210790539
Pubmed

The transcriptional co-repressor TLE3 regulates development of trophoblast giant cells lining maternal blood spaces in the mouse placenta.

TLE3 NOTCH2

7.07e-06293223954203
Pubmed

Caspr3-Deficient Mice Exhibit Low Motor Learning during the Early Phase of the Accelerated Rotarod Task.

CNTNAP3B CNTNAP3

7.07e-06293226807827
Pubmed

Association of a polymorphism in the NRXN3 gene with the degree of smoking in schizophrenia: a preliminary study.

NRXN3 NRXN1

7.07e-06293219658047
Pubmed

The Tat protein of the caprine arthritis encephalitis virus interacts with the Notch2 EGF-like repeats and the epithelin/granulin precursor.

GRN NOTCH2

7.07e-06293212931033
Pubmed

notch2, notch4 gene polymorphisms in psoriasis vulgaris.

NOTCH2 NOTCH4

7.07e-06293223587900
Pubmed

Inflammation dysregulates Notch signaling in endothelial cells: implication of Notch2 and Notch4 to endothelial dysfunction.

NOTCH2 NOTCH4

7.07e-06293220643108
Pubmed

Notch signaling in kidney development.

JAG2 NOTCH2

7.07e-06293212496659
Pubmed

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development.

JAG2 NOTCH2 NOTCH4

8.23e-061593312971992
Pubmed

Expression of Notch pathway components in fetal and adult mouse small intestine.

JAG2 NOTCH2 NOTCH4

1.01e-051693312617809
Pubmed

Notch gene expression during pancreatic organogenesis.

JAG2 NOTCH2 NOTCH4

1.01e-051693310842072
Pubmed

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation.

JAG2 NOTCH2 NOTCH4

1.01e-051693317273555
Pubmed

Gamma-secretase activation of notch signaling regulates the balance of proximal and distal fates in progenitor cells of the developing lung.

JAG2 NOTCH2 NOTCH4

1.22e-051793318694942
Pubmed

Segmental expression of Notch and Hairy genes in nephrogenesis.

JAG2 NOTCH2 NOTCH4

1.22e-051793315821257
Pubmed

Developmental coronary maturation is disturbed by aberrant cardiac vascular endothelial growth factor expression and Notch signalling.

JAG2 NOTCH2 NOTCH4

1.47e-051893318093989
Pubmed

RBPjkappa-dependent Notch function regulates Gata2 and is essential for the formation of intra-embryonic hematopoietic cells.

JAG2 NOTCH2 NOTCH4

1.47e-051893315689374
Pubmed

Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia.

JAG2 PCSK5 MEGF8 GRN LTBP1

1.69e-0511893521078624
Pubmed

Notch 2 and Notch 1/3 segregate to neuronal and glial lineages of the developing olfactory epithelium.

JAG2 NOTCH2 NOTCH4

1.74e-051993316518823
Pubmed

Deterministic and stochastic allele specific gene expression in single mouse blastomeres.

JAG2 ADAM23 TLE3 TLE4 LRP4 GDF9 NOTCH2 NOTCH4

1.88e-0542493821731673
Pubmed

Endogenous β-neurexins on axons and within synapses show regulated dynamic behavior.

NRXN3 NRXN1

2.12e-05393234133920
Pubmed

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+ Influx.

NRXN3 NRXN1

2.12e-05393238891114
Pubmed

Notch signaling drives multiple myeloma induced osteoclastogenesis.

JAG2 NOTCH2

2.12e-05393225257302
Pubmed

Clinicopathological analysis of ATRX, DAXX and NOTCH receptor expression in angiosarcomas.

ATRX NOTCH2

2.12e-05393228796347
Pubmed

ADAM 23/MDC3, a human disintegrin that promotes cell adhesion via interaction with the alphavbeta3 integrin through an RGD-independent mechanism.

ADAM23 ITGB3

2.12e-05393210749942
Pubmed

αVβ8 integrin targeting to prevent posterior capsular opacification.

ITGB6 ITGB8

2.12e-05393234554928
Pubmed

The within-subject application of diffusion tensor MRI and CLARITY reveals brain structural changes in Nrxn2 deletion mice.

NRXN3 NRXN1

2.12e-05393230858964
Pubmed

Differential expression of Notch genes in human osteoblastic cells.

NOTCH2 NOTCH4

2.12e-05393211836628
Pubmed

Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.

NRXN3 NRXN1

2.12e-05393228013231
Pubmed

Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A.

PCSK5 LTBP2

2.12e-05393221700711
Pubmed

alpha-Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction.

NRXN3 NRXN1

2.12e-05393216406382
Pubmed

Ketamine Restores Thalamic-Prefrontal Cortex Functional Connectivity in a Mouse Model of Neurodevelopmental Disorder-Associated 2p16.3 Deletion.

NRXN3 NRXN1

2.12e-05393231812984
Pubmed

Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction.

JAG2 NOTCH2

2.12e-05393218458347
Pubmed

αvβ6- and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion.

ITGB6 ITGB8

2.12e-05393224367260
Pubmed

Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing.

NRXN3 NRXN1

2.12e-05393212036300
Pubmed

Reduced USP33 expression in gastric cancer decreases inhibitory effects of Slit2-Robo1 signalling on cell migration and EMT.

SLIT2 USP33

2.12e-05393230896071
Pubmed

β-Neurexins Control Neural Circuits by Regulating Synaptic Endocannabinoid Signaling.

NRXN3 NRXN1

2.12e-05393226213384
Pubmed

Neurexin gene family variants as risk factors for autism spectrum disorder.

NRXN3 NRXN1

2.12e-05393229045040
Pubmed

Alternative Splicing of Presynaptic Neurexins Differentially Controls Postsynaptic NMDA and AMPA Receptor Responses.

NRXN3 NRXN1

2.12e-05393231005376
Pubmed

Structural and functional characterization of the IgSF21-neurexin2α complex and its related signaling pathways in the regulation of inhibitory synapse organization.

NRXN3 NRXN1

2.12e-05393238571813
Pubmed

Deletion of β-Neurexins in Mice Alters the Distribution of Dense-Core Vesicles in Presynapses of Hippocampal and Cerebellar Neurons.

NRXN3 NRXN1

2.12e-05393235173587
Pubmed

The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development.

CELSR3 CELSR2

2.12e-05393211677057
Pubmed

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.

NOTCH2 NOTCH4

2.12e-05393211823422
Pubmed

USP33, a new player in lung cancer, mediates Slit-Robo signaling.

SLIT2 USP33

2.12e-05393224981056
Pubmed

LTBP-2 specifically interacts with the amino-terminal region of fibrillin-1 and competes with LTBP-1 for binding to this microfibrillar protein.

LTBP1 LTBP2

2.12e-05393217293099
Pubmed

Notch signaling: cell fate control and signal integration in development.

NOTCH2 NOTCH4

2.12e-05393210221902
Pubmed

Dissociation of HSV gL from gH by αvβ6- or αvβ8-integrin promotes gH activation and virus entry.

ITGB6 ITGB8

2.12e-05393226157134
Pubmed

Integrins as triggers of Epstein-Barr virus fusion and epithelial cell infection.

ITGB6 ITGB8

2.12e-05393221178476
Pubmed

Interaction of alphaVbeta3 and alphaVbeta6 integrins with human parechovirus 1.

ITGB3 ITGB6

2.12e-05393220554778
Pubmed

Integrin expression and glycosylation patterns regulate cell-matrix adhesion and alter with breast cancer progression.

ITGB3 ITGB6

2.12e-05393229577899
Pubmed

Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.

JAG2 NOTCH2

2.12e-05393228572448
Pubmed

Pharmacologic Blockade of αvβ1 Integrin Ameliorates Renal Failure and Fibrosis In Vivo.

ITGB3 ITGB8

2.12e-05393228220032
Pubmed

Neurexins are differentially expressed in the embryonic nervous system of mice.

NRXN3 NRXN1

2.12e-0539327722633
Pubmed

Regulated Dynamic Trafficking of Neurexins Inside and Outside of Synaptic Terminals.

NRXN3 NRXN1

2.12e-05393226446217
Pubmed

The Notch-mediated circuitry in the evolution and generation of new cell lineages: the tooth model.

JAG2 NOTCH2

2.12e-05393237330998
Pubmed

Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity.

NRXN3 NRXN1

2.12e-05393211944992
Pubmed

Alternative splicing of neurexins 1-3 is modulated by neuroinflammation in the prefrontal cortex of a murine model of multiple sclerosis.

NRXN3 NRXN1

2.12e-05393233058888
Pubmed

Important contribution of alpha-neurexins to Ca2+-triggered exocytosis of secretory granules.

NRXN3 NRXN1

2.12e-05393217035546
Pubmed

Neurexins: three genes and 1001 products.

NRXN3 NRXN1

2.12e-0539329448462
Pubmed

Deletion of α-neurexin II results in autism-related behaviors in mice.

NRXN3 NRXN1

2.12e-05393225423136
Pubmed

Tle corepressors are differentially partitioned to instruct CD8+ T cell lineage choice and identity.

TLE3 TLE4

2.12e-05393230045946
Pubmed

The gene organization of the human beta 7 subunit, the common beta subunit of the leukocyte integrins HML-1 and LPAM-1.

ITGB3 ITGB6

2.12e-0539321382574
Pubmed

Latent transforming growth factor-beta binding proteins (LTBPs)--structural extracellular matrix proteins for targeting TGF-beta action.

LTBP1 LTBP2

2.12e-05393210743502
InteractionFBXO2 interactions

TINAGL1 JAG2 PCSK5 SLIT2 CNTNAP3B CELSR3 MEGF8 ADAM23 CNTNAP3 GRN GDF9 PLXNB2 ERVMER34-1 LRP1B NOTCH2

1.98e-104118615int:FBXO2
InteractionIGFL3 interactions

JAG2 PCSK5 UBR5 LRP4 GRN LRP1B NOTCH2

3.15e-0875867int:IGFL3
InteractionNTN5 interactions

JAG2 LRP4 LTBP1 LRP1B NOTCH2

5.02e-0824865int:NTN5
InteractionSLURP1 interactions

PCSK5 CNTNAP3B MEGF8 CNTNAP3 GRN PLXNB2 ERVMER34-1 NOTCH2

1.85e-07144868int:SLURP1
InteractionCBLN4 interactions

CNTNAP3B NRXN3 CELSR2 MEGF8 PDGFRL CNTNAP3 PLXNB2

1.19e-06127867int:CBLN4
InteractionATN1 interactions

JAG2 HINFP PCSK5 MEGF8 ATRX TLE3 GRN LTBP1

1.35e-06187868int:ATN1
InteractionCD160 interactions

PCSK5 CELSR3 CELSR2 CNTNAP3 PLXNB2

1.86e-0648865int:CD160
InteractionZFP41 interactions

LRP4 GRN LTBP1 LRP1B NOTCH2

4.42e-0657865int:ZFP41
InteractionCACNA1A interactions

JAG2 PCSK5 MEGF8 SCN9A GRN LTBP1

1.44e-05123866int:CACNA1A
InteractionRNASE4 interactions

CNTNAP3 LRP1B NOTCH2

2.64e-0514863int:RNASE4
InteractionZNF408 interactions

LRP4 GRN LTBP1 LTBP2 LRP1B NOTCH2

3.66e-05145866int:ZNF408
InteractionRETNLB interactions

RETNLB CNTNAP3 LTBP1

4.89e-0517863int:RETNLB
InteractionPATE1 interactions

JAG2 CNTNAP3 PLXNB2 LRP1B

5.66e-0549864int:PATE1
InteractionSDF2L1 interactions

JAG2 PCSK5 CNTNAP3B MEGF8 CNTNAP3 PLXNB2 ERVMER34-1 CTSS

7.01e-05322868int:SDF2L1
InteractionTRGV3 interactions

CNTNAP3B MEGF8 CNTNAP3 PLXNB2

8.93e-0555864int:TRGV3
InteractionLYPD1 interactions

JAG2 PCSK5 MEGF8 NOTCH2

1.10e-0458864int:LYPD1
InteractionHOXA1 interactions

JAG2 PCSK5 SLIT2 MEGF8 SIVA1 GRN LTBP1 PLSCR3

1.40e-04356868int:HOXA1
InteractionCNTNAP3 interactions

JAG2 CNTNAP3B RETNLB CNTNAP3 PLXNB2

1.45e-04117865int:CNTNAP3
InteractionFBN2 interactions

TRIM33 LTBP1 LTBP2 NOTCH2

1.72e-0465864int:FBN2
InteractionIL5RA interactions

PCSK5 CELSR2 MEGF8 CNTNAP3 PLXNB2

1.90e-04124865int:IL5RA
InteractionCFC1 interactions

PCSK5 CNTNAP3B MEGF8 CNTNAP3 NOTCH2

2.05e-04126865int:CFC1
InteractionPRG2 interactions

TINAGL1 JAG2 PCSK5 CNTNAP3B CELSR2 CNTNAP3 NOTCH2

2.18e-04285867int:PRG2
InteractionZSCAN21 interactions

LRP4 GRN LTBP2 LRP1B NOTCH2

2.21e-04128865int:ZSCAN21
InteractionFEZF1 interactions

TLE4 LRP4 LRP1B

2.28e-0428863int:FEZF1
InteractionCDH16 interactions

CELSR2 CNTNAP3 LTBP1

2.28e-0428863int:CDH16
InteractionFIBIN interactions

JAG2 CNTNAP3B MEGF8 CNTNAP3

2.42e-0471864int:FIBIN
InteractionPCDH20 interactions

CNTNAP3B CELSR3 CELSR2 LTBP1

2.42e-0471864int:PCDH20
InteractionASIC4 interactions

JAG2 CNTNAP3B CNTNAP3 NFXL1 PLXNB2

2.73e-04134865int:ASIC4
InteractionGFI1B interactions

JAG2 MEGF8 UBR5 TLE3 GRN

2.92e-04136865int:GFI1B
InteractionLY86 interactions

JAG2 PCSK5 CNTNAP3B CELSR2 CNTNAP3 PLXNB2

3.34e-04217866int:LY86
InteractionLILRA5 interactions

JAG2 CNTNAP3B CNTNAP3

3.40e-0432863int:LILRA5
InteractionTAFA3 interactions

PPP2R2A BIRC2 GRN LRP1B

3.47e-0478864int:TAFA3
InteractionZNF594 interactions

LTBP2 NOTCH2

3.73e-047862int:ZNF594
InteractionCELA3A interactions

PCSK5 CNTNAP3 NFXL1

4.08e-0434863int:CELA3A
InteractionZNF74 interactions

JAG2 LRP4 LTBP2

4.08e-0434863int:ZNF74
GeneFamilyCD molecules|Integrin beta subunits

ITGB3 ITGB6 ITGB8

2.73e-0695931159
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR3 CELSR2

3.13e-053592913
GeneFamilyAdhesion G protein-coupled receptors, subfamily C|CELSR cadherins

CELSR3 CELSR2

3.13e-0535921189
GeneFamilyLatent transforming growth factor beta binding proteins

LTBP1 LTBP2

6.26e-054592628
GeneFamilyC-type lectin domain family

CLEC18A CLEC18B CLEC18C

4.83e-0447593494
GeneFamilyLow density lipoprotein receptors

LRP4 LRP1B

7.98e-0413592634
CoexpressionNABA_MATRISOME

TINAGL1 PCSK5 SLIT2 CLEC18A HGFAC EYS CLEC18B MEGF8 ADAM23 CLEC18C LTBP1 LTBP2 TECTA GDF9 PLXNB2 TNR CTSS

6.60e-0810269017M5889
CoexpressionNABA_MATRISOME

TINAGL1 PCSK5 SLIT2 CLEC18A HGFAC CLEC18B MEGF8 ADAM23 CLEC18C LTBP1 LTBP2 TECTA GDF9 PLXNB2 TNR CTSS

3.02e-0710089016MM17056
CoexpressionNABA_ECM_GLYCOPROTEINS

TINAGL1 SLIT2 EYS LTBP1 LTBP2 TECTA TNR

5.19e-06196907M3008
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 NOTCH2 NOTCH4

2.12e-0516903MM1296
CoexpressionFUKUSHIMA_TNFSF11_TARGETS

JAG2 NOTCH2 NOTCH4

2.12e-0516903M2207
CoexpressionNABA_CORE_MATRISOME

TINAGL1 SLIT2 EYS LTBP1 LTBP2 TECTA TNR

4.61e-05275907M5884
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

CELSR2 TLE3 RETNLB SIVA1 LTBP1 LTBP2 PPIH TENM2 DKK2 TG

4.66e-056109010M3854
CoexpressionNABA_ECM_GLYCOPROTEINS

TINAGL1 SLIT2 LTBP1 LTBP2 TECTA TNR

5.19e-05191906MM17059
CoexpressionMARTINEZ_RB1_AND_TP53_TARGETS_DN

CELSR2 TLE3 RETNLB SIVA1 LTBP1 LTBP2 PPIH TENM2 DKK2 TG

7.90e-056509010MM1042
CoexpressionAtlasFacebaseRNAseq_e10.5_Medial Nasal Eminence_top-relative-expression-ranked_1000

SLIT2 CELSR2 ATRX SLC17A1 ADAM23 SCN9A ELAPOR1 LRP4 LTBP1 SHISA4 MAP3K6 ITGB6 ITGB8 CTSS PSD4

9.52e-069798715Facebase_RNAseq_e10.5_Medial Nasal Eminence_1000
CoexpressionAtlasECTO blastocyst_vs_ECTO bone marrow-Confounder_removed-fold2.0_adjp0.05

SLIT2 CLEC18A CLEC18B LRP4 CLEC18C LTBP1

2.71e-05143876PCBC_ratio_ECTO blastocyst_vs_ECTO bone marrow_cfr-2X-p05
ToppCellParenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

TINAGL1 JAG2 PCSK5 CNTNAP3B CNTNAP3 CUBN DKK2 NOTCH4

7.96e-09197928ad4a3b5da2190be9495382a2952991e1de9f190d
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

EYS NRXN1 SLC17A1 CUBN TNR LRP1B

4.47e-07139926a1945b07f177cde40e7eea03a19236ce76165857
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 NRXN3 SLC16A5 ADAM23 SCN9A TENM2

9.48e-07158926f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCSK5 NRXN3 SLC16A5 ADAM23 SCN9A TENM2

9.48e-071589268c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellfacs-Diaphragm-Limb_Muscle-24m|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NRXN3 SCN9A LTBP2 CUBN DNAH6 LRP1B

1.40e-0616992612bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

JAG2 PCSK5 GABRG1 HTR4 DKK2 NOTCH4

1.66e-0617492618ab52d8bbca0507fee220e0c4fc765fc47dda34
ToppCellfacs-Aorta|facs / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 APOLD1 LTBP2 TECTA DNAH6 DKK2

1.78e-061769260b3491451be02c18a16cdb875645be47eb867a7f
ToppCellPCW_13-14-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

JAG2 CNTNAP3B EYS CNTNAP3 DKK2 NOTCH4

1.90e-06178926c227da59dc7beb73f84405bf13356bdeb59d9338
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC17A1 UGT2B7 CUBN LRP1B ITGB6 ITGB8

2.16e-061829269d67717a6e13bcb54c1297a3e4e3abf4e51628a3
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 HTR4 PDGFRL LRP4 LTBP1 LTBP2

2.23e-061839267eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-pulmonary_artery_endothelial_cell-EC_arterial-EC_arterial_L.2.4.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TINAGL1 JAG2 CUBN ERVMER34-1 DKK2 NOTCH4

2.23e-06183926ce8be9418b473ea94ec806edc7a2078cc30c1703
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B EYS HTR4 SCN9A CNTNAP3

2.23e-0618392604d3cc76038b8192c915f1c08c3e26f2ad3b3779
ToppCellPCW_10-12-Endothelial-Endothelial_mature-endo_arterial_(9)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

JAG2 CNTNAP3B EYS CNTNAP3 DKK2 NOTCH4

2.30e-06184926a809b0fa52df8a159f60f87eefcef61220af5e34
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B EYS HTR4 SCN9A CNTNAP3

2.37e-06185926e87e6e097dc29ece8aea671935bde281b99b93ea
ToppCellCOVID-19-kidney-tDL|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

2.52e-06187926d35d27ca3c0e65f92f4508e1cb98a743f44fdcdf
ToppCelldroplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

JAG2 PCSK5 MAP3K6 ITGB3 DKK2 NOTCH4

2.52e-06187926e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCellCOVID-19-kidney-PCT-S2|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

2.68e-061899260be5c669b6b308bd98ddb70c84877c62a6244bbd
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B EYS HTR4 SCN9A CNTNAP3

2.76e-061909263f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B EYS HTR4 SCN9A CNTNAP3

2.76e-0619092639ab890104b4264c68a968f920f4ccd84f0bc681
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B EYS HTR4 SCN9A CNTNAP3

2.76e-061909260acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_large_blood_vessel-SVEC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

TINAGL1 CNTNAP3B ADAM23 RNF122 ITGB3 NOTCH4

2.94e-06192926c3dda7c48732b0b8bde36de282d64192f5e9b98f
ToppCelldroplet-Kidney-nan-18m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 JAG2 PCSK5 APOLD1 DKK2 NOTCH4

2.94e-06192926144503af50274eaed5cf6effa892c640eab28663
ToppCelldroplet-Kidney-nan-18m-Endothelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 JAG2 PCSK5 APOLD1 DKK2 NOTCH4

2.94e-06192926c96736bb3a6bb052678b1b078f7823063ca69e6d
ToppCellIPF-Endothelial-VE_Arterial|World / Disease state, Lineage and Cell class

TINAGL1 JAG2 CNTNAP3B LTBP1 DKK2 NOTCH4

3.03e-0619392670a9aadda83a97e06e9bc2d1327ce60dd3c58767
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 PPP2R2A LTBP1 CUBN SHISA4 DKK2

3.12e-06194926582db7f7fa9aa08027ae18ed607945b5d1dc908a
ToppCell(6)_Endothelial-B_(Artery)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

TINAGL1 JAG2 CNTNAP3B CUBN DKK2 NOTCH4

3.12e-061949260cf4e67d4024652794b5bfdd4a71a7d98900b4c8
ToppCell343B-Endothelial_cells-Endothelial-B_(Artery)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

PCSK5 PPP2R2A LTBP1 CUBN SHISA4 DKK2

3.12e-06194926bda89111386398a072b70e8153b2a762298a047a
ToppCellfacs-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PDGFRL ADAM23 SHISA4 RNF122 DKK2 PLAC8

3.21e-0619592618b01ab63ee1deae3cf29669d66fff9ca4efc5c4
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_systemic-EC_venous_systemic_L.2.2.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TINAGL1 CNTNAP3B APOLD1 ADAM23 CNTNAP3 RNF122

3.31e-061969265609b2d93172a488b35d854298a3a4e504e17e28
ToppCellBronchial-NucSeq-Stromal-Schwann|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

SLIT2 NRXN3 NRXN1 ADAM23 SHISA4 ITGB8

3.31e-06196926a90c76d9c57a4491b94a321ba541b792ec5d8e83
ToppCell(4)_Endothelial_cells-(41)_EC-arteriolar|(4)_Endothelial_cells / Cell class and subclass of bone marrow stroma cells in homeostatis

JAG2 PCSK5 LRP4 SLCO3A1 DKK2 NOTCH4

3.40e-06197926482e3f8926880afed88ed37553ed2b5ed58b8c99
ToppCellEpithelial_cells-Basal_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

TINAGL1 JAG2 LRP4 LTBP2 TENM2 ITGB8

3.51e-061989264235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-MEPE-|Neuronal / cells hierarchy compared to all cells using T-Statistic

TINAGL1 SLIT2 CNTNAP3B EYS SCN9A CNTNAP3

3.71e-06200926d4161fcbbe47236aac4a077c0994887e765b0b47
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons|GW26 / Sample Type, Dataset, Time_group, and Cell type.

JAG2 SLIT2 NRXN3 SCN9A SLCO3A1 TENM2

3.71e-06200926bad32a95b759fad509401b07bc96a56687c2a592
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-MEPE|Neuronal / cells hierarchy compared to all cells using T-Statistic

TINAGL1 SLIT2 CNTNAP3B EYS SCN9A CNTNAP3

3.71e-062009260d0c69758370d3c44ffe6640e332b6118fc5ce58
ToppCellLPS_IL1RA_TNF-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

PCSK5 HTR4 PDGFRL LRP4 LTBP1 LTBP2

3.71e-0620092609537dc25f8b8b4654a7c183827ee1522a41a4e0
ToppCellNeuronal-Inhibitory-iB-iB_2(PVALB)-MEPE--L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

TINAGL1 SLIT2 CNTNAP3B EYS SCN9A CNTNAP3

3.71e-06200926c546fa80876640bd57a5252df611977009bef9e8
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GABRG1 HTR4 SCN9A TECTA LRP1B

1.27e-0514592596712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellTCGA-Kidney|World / Sample_Type by Project: Shred V9

CLEC18A CLEC18B SLC17A1 UGT2B7 CUBN

1.55e-05151925e31974c0d0a0c644205a0ee6013ab74a09d8a306
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Differentiating_glia|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PCSK5 CLEC18B NRXN1 ZDHHC22 SCN9A

2.51e-0516792517c653b46507c8bb85da95836ae72a6015336142
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A3 SLC16A5 NCAPG2 CTSS TG

2.59e-0516892541da200bbff5c663c39f67c38d6d5f43b0ad9494
ToppCellfacs-Lung-EPCAM-24m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC12A3 SLC16A5 NCAPG2 CTSS TG

2.59e-05168925a77259c13508f19186d7b0f80b34dc6d89497ab5
ToppCell3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN3 NRXN1 TLE3 SCN9A LTBP1

2.66e-051699252456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCellControl-Stromal_mesenchymal-Lung_smooth_muscle-Pericyte_2|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLIT2 NRXN1 APOLD1 LRP1B NOTCH2

2.74e-051709255570c0e825bca77613bf0ebde620cf744fa1cb84
ToppCellASK440-Epithelial-Transformed_epithelium|ASK440 / Donor, Lineage and Cell class of Lung cells from Dropseq

CELSR2 SLC16A5 ELAPOR1 CNTNAP3 LTBP2

2.90e-05172925df3800bcd9777d02900eba0cfc26ab73de8a1d95
ToppCellCOVID-19-kidney-Distal_Epi_Doublet_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

SLC17A1 UGT2B7 CUBN LRP1B ITGB6

3.23e-0517692536f77d878a53b30465b0dea8333a3865dba75613
ToppCellFetal_29-31_weeks-Endothelial-endothelial_cell_of_artery|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

JAG2 PCSK5 MAP3K6 DKK2 NOTCH4

3.32e-051779255ff8dcfb030312126695d53a026d2e104a401b83
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 CNTNAP3B TLE4 CNTNAP3 TECTA

3.32e-051779254c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EYS ELAPOR1 SLCO3A1 SCART1 PSD4

3.41e-051789250b59e3d75b143bd7bf91a7800a49699c51e68c5a
ToppCellwk_15-18-Mesenchymal-Mesothelial-intermediate_mesothelial|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

IGFL2 SLURP2 ITGB8 CRB2 TG

3.50e-05179925b1f085e4c8d65d5cdbfaf2db80343638abb08979
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TINAGL1 SLIT2 CNTNAP3B SCN9A CNTNAP3

3.50e-05179925d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCSK5 HTR4 PDGFRL LRP4 LTBP2

3.50e-0517992502c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell3'-GW_trimst-1-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

EYS SIGLEC7 RASAL3 SCART1 PSD4

3.50e-05179925dd3cf8fd10dc257d933a7f45860dc2e244c158b7
ToppCellCOVID-19-Heart-EC_2|COVID-19 / Disease (COVID-19 only), tissue and cell type

JAG2 PCSK5 CNTNAP3B DKK2 NOTCH4

3.50e-051799252a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCellCOVID-19-kidney-PCT-S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

3.60e-05180925358923e4228035a3e90e2957392089219e90dcd7
ToppCellCOVID-19-kidney-tDL|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

3.60e-05180925864c895b5eaedefae86f5829fa344f7b686fb59f
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_vein-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

TINAGL1 CNTNAP3B ADAM23 CNTNAP3 MAP3K6

3.60e-0518092527e8bbee388e64dd79d70b160b76d45b1f398006
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

NRXN3 CELSR2 NRXN1 ADAM23 SCN9A

3.69e-05181925a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3 DNAH6 LRP1B ITGB8 DKK2

3.69e-051819259de2f2cc5f02e0ca599c9e0d2cb1e1e4b5aac112
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TINAGL1 SLIT2 CNTNAP3B SCN9A CNTNAP3

3.79e-05182925d4cb23b5a974c096a0ce84b47fe351eef44894d7
ToppCelldroplet-Thymus-nan-18m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 MEGF8 ADAM23 GRN DNAH6

3.79e-05182925f6717e97e87513384149800c9fd8dea821ab9393
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TINAGL1 SLIT2 CNTNAP3B EYS CNTNAP3

3.79e-05182925a3c5c0eff527c8d3848acda14af8f9e99c69b0de
ToppCelldroplet-Thymus-nan-18m-Myeloid-professional_antigen_presenting_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 MEGF8 ADAM23 GRN DNAH6

3.79e-05182925c33b0d532822186a1e8e645500347972468718c0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TINAGL1 SLIT2 CNTNAP3B SCN9A CNTNAP3

3.89e-05183925121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCellwk_15-18-Epithelial-PNS-intermediate_Schwann|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

TINAGL1 NRXN3 NRXN1 ADAM23 ITGB8

3.89e-05183925d874aa9a856f79626c8a8371f6196a77b7d662ee
ToppCell(7)_DC_plasmacytoid|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

SLC12A3 SCN9A GRN PLXNB2 NOTCH4

3.89e-051839252c6475c935b5a90931be6b3c53f1f707cfcd11f4
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CNTNAP3B EYS HTR4 SCN9A CNTNAP3

3.99e-051849252ba98708dfd7f1b2a661578a334684094ff453ad
ToppCellCOVID-19-kidney-PCT-S1/S2|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 SLIT2 CNTNAP3B SLC17A1 CUBN

3.99e-05184925dc71f22583fc54b89b242cbb602f4bbe86f576ec
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_FAM150B|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B HTR4 SCN9A CNTNAP3

3.99e-051849257d41784eac0935e77d6bc701f20c693adf998730
ToppCellP28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TINAGL1 PCSK5 APOLD1 DKK2 PLAC8

3.99e-051849258ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCellmetastatic_Brain-Endothelial_cells-Stalk-like_ECs|metastatic_Brain / Location, Cell class and cell subclass

CNTNAP3B APOLD1 CUBN DKK2 NOTCH4

4.10e-05185925ad52970e88e8947ef256095bd4b40229b912d58a
ToppCellEndothelial-A-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

TINAGL1 CNTNAP3B CNTNAP3 DKK2 NOTCH4

4.10e-05185925ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCellCOVID-19-kidney-Mito-rich_PCT|COVID-19 / Disease (COVID-19 only), tissue and cell type

CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

4.10e-051859251bbc2ba8a20f72f61981b1301cdd6018cdd9150d
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

TINAGL1 SLIT2 CNTNAP3B SCN9A CNTNAP3

4.10e-05185925f4ac62009c0ad3346e71b809e17727303c4df153
ToppCellControl-Endothelial-Endothelial-Artery|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

JAG2 PCSK5 LTBP1 LRP1B DKK2

4.21e-051869252d3a975d2bf92e18e3410dd413fc9f84831d82de
ToppCell356C-Endothelial_cells-Endothelial-E-|356C / Donor, Lineage, Cell class and subclass (all cells)

CNTNAP3 CUBN GDF9 DKK2 NOTCH4

4.21e-051869252e024097ee361eeb1d855a4edb8ac8cdad35da06
ToppCell356C-Endothelial_cells-Endothelial-E|356C / Donor, Lineage, Cell class and subclass (all cells)

CNTNAP3 CUBN GDF9 DKK2 NOTCH4

4.21e-05186925c3449e54454009973818fc1101933c6f0168258c
ToppCellAnterior_Cingulate_gyrus_(CgG)|World / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PCSK5 CNTNAP3B SCN9A CNTNAP3 PSD4

4.21e-0518692532af3f211f9ad5d5c6b86b83325cfbf2f8466b56
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B EYS SCN9A CNTNAP3

4.31e-05187925d413fb4b1531b297af5012a392b88128510c2de8
ToppCellIIH-pDC-|IIH / Condition, Cell_class and T cell subcluster

SLC12A3 SCN9A GRN PLAC8 NOTCH4

4.31e-05187925ad87b146ea8dd9f695e722f8f0e8e1057c7f3167
ToppCellIIH-pDC|IIH / Condition, Cell_class and T cell subcluster

SLC12A3 SCN9A GRN PLAC8 NOTCH4

4.31e-051879255e59e9153a18bcfb5c8dc94599080216661de7ce
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 CNTNAP3B SLC17A1 UGT2B7 CUBN

4.31e-05187925dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

JAG2 PCSK5 CNTNAP3B DKK2 NOTCH4

4.31e-0518792540ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PCSK5 CNTNAP3B SLC17A1 UGT2B7 CUBN

4.31e-05187925f1356273bd3587b6883295edf15cb9cdb706c057
ToppCellCOVID-19-kidney|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLC17A1 UGT2B7 CUBN LRP1B ITGB8

4.31e-05187925d23aae9419d460b78b1d4092d7acd9108a47cfbe
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-myocytic-SMC_(PLPP2+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TINAGL1 NRXN3 LTBP1 LTBP2 DKK2

4.31e-051879253912bbb610a4a84791e9bda92a2d57a52c31d29e
ToppCellCOVID-19-kidney-Stressed_PCT|kidney / Disease (COVID-19 only), tissue and cell type

PCSK5 SLIT2 CNTNAP3B SLC17A1 CUBN

4.31e-05187925acd305475f3609800af0d7bc68d83ef41228080b
ToppCellP15-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TINAGL1 PCSK5 DKK2 PLAC8 NOTCH4

4.42e-0518892550b27fc12347ca16bd62333baf345c83cb422a8f
ToppCellkidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

TINAGL1 JAG2 CNTNAP3B APOLD1 NOTCH4

4.42e-05188925a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCellCOVID-19-Heart-Fib_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

SLIT2 HTR4 PDGFRL LTBP1 LTBP2

4.42e-05188925fe361215f4ba841aa5e1e581fb56f2f4d3ccd201
ToppCellTCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6|TCGA-Breast / Sample_Type by Project: Shred V9

PCSK5 SLIT2 LTBP2 DKK2 NOTCH4

4.42e-05188925c90669b51e1902fe7726555290c91c92a911df83
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLIT2 CNTNAP3B EYS SCN9A CNTNAP3

4.42e-051889258de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellP28-Endothelial-large_vessel_endothelial_cell|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

TINAGL1 PCSK5 APOLD1 DKK2 PLAC8

4.42e-05188925263169029293e005bcffd87db20221fdd2d3917e
ToppCelldroplet-Kidney-nan-21m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TINAGL1 JAG2 PCSK5 APOLD1 NOTCH4

4.54e-051899252ce330d8078833c05775c481e73770f9ee4a5c88
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

4.54e-05189925204ab61ae606b2d9be0cb6bf6a83a011740693a8
ToppCellEndothelial-endothelial_cell_of_artery|World / Lineage, Cell type, age group and donor

JAG2 CNTNAP3B CNTNAP3 DKK2 NOTCH4

4.54e-05189925fdd89c71113ac99b7c800c6def8888e512ff1128
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC16A5 SLCO3A1 DNAH6 LRP1B ITGB6

4.54e-05189925e059be2965cca70ff5576df055d0af1775b76e00
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

4.54e-0518992513fd07cc408a9486f61a7b2c3a132c52d14b438d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

JAG2 PCSK5 CNTNAP3B CNTNAP3 NOTCH4

4.54e-051899256463890d8dbee4bc198f91628a5f784970de786a
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

CNTNAP3B SLC17A1 UGT2B7 CUBN ITGB8

4.54e-0518992528b502611829e4a24caff2562545c7db97686099
Diseasesevere acute respiratory syndrome, COVID-19

EYS NRXN1 ADAM23 LTBP2 TNR LRP1B TENM2 TG

4.92e-05447868EFO_0000694, MONDO_0100096
DiseaseX-25371 measurement

SLC17A1 SCART1

8.35e-055862EFO_0800923
Diseasebombesin receptor-activated protein C6orf89 measurement

RASAL3 CUBN

8.35e-055862EFO_0801428
Diseasevisceral heterotaxy (implicated_via_orthology)

PCSK5 SLIT2 MEGF8

1.73e-0437863DOID:0050545 (implicated_via_orthology)
DiseasePolysyndactyly

JAG2 LRP4

1.75e-047862C0265553
Diseasetriacylglycerol 58:6 measurement

LRP1B TENM2

2.32e-048862EFO_0010440
Diseaseautosomal recessive intellectual developmental disorder (implicated_via_orthology)

CNTNAP3B CNTNAP3

2.32e-048862DOID:0060308 (implicated_via_orthology)
DiseaseSyndactyly

JAG2 LRP4

2.32e-048862C0039075
Diseaselymphocyte count

RASAL3 HTR4 APOLD1 TLE4 RETNLB CLEC18C OR2W5P WDR27 LTBP2 PLXNB2 CTSS NOTCH2 PSD4

3.10e-0414648613EFO_0004587
Diseasetelomere length

NRXN3 CLEC18C SLCO3A1 SPOP TNR DKK2

3.13e-04313866EFO_0004505
DiseaseGlioblastoma Multiforme

JAG2 TRIM33 ATRX NOTCH2

3.18e-04111864C1621958
Diseaselung adenocarcinoma (is_implicated_in)

UBR5 SPOP LRP1B

4.00e-0449863DOID:3910 (is_implicated_in)
Diseasecalcium measurement

HINFP HGFAC CELSR2 APOLD1 TLE3 TLE4 LRP1B CTSS

4.98e-04628868EFO_0004838
Diseasecomplement C1q tumor necrosis factor-related protein 1 measurement

CELSR2 GRN

5.44e-0412862EFO_0801493
Diseasegranulins measurement

CELSR2 GRN

5.44e-0412862EFO_0008141
Diseasedementia (is_implicated_in)

GRN NOTCH4

5.44e-0412862DOID:1307 (is_implicated_in)
DiseaseX-19141 measurement

SLC17A1 UGT2B7

6.41e-0413862EFO_0800799
Diseasegestational age

SLIT2 EYS UBR5 UGT2B7

7.23e-04138864EFO_0005112
Diseaserelapsing-remitting multiple sclerosis (is_marker_for)

GRN CTSS

8.60e-0415862DOID:2378 (is_marker_for)
Diseaseamyotrophic lateral sclerosis, age at onset

PCSK5 NRXN3

8.60e-0415862EFO_0004847, MONDO_0004976
DiseaseGraves' disease (is_marker_for)

ITGB3 TG

8.60e-0415862DOID:12361 (is_marker_for)
Diseaseradiation-induced disorder

SLIT2 PPP2R2A NRXN1

1.00e-0367863EFO_0009565
Diseaseautism spectrum disorder (implicated_via_orthology)

CNTNAP3B NRXN3 NRXN1 CNTNAP3

1.04e-03152864DOID:0060041 (implicated_via_orthology)
DiseaseAstrocytosis

TNR ITGB3

1.11e-0317862C3887640
DiseaseGliosis

TNR ITGB3

1.11e-0317862C0017639
DiseaseMalignant neoplasm of breast

JAG2 TLE3 ELAPOR1 BIRC2 CUBN TECTA MAP3K6 VPS13B NOTCH2 NOTCH4

1.13e-0310748610C0006142
Diseasetransient cerebral ischemia (biomarker_via_orthology)

SLIT2 NRXN1 LTBP1 ITGB3

1.17e-03157864DOID:224 (biomarker_via_orthology)
Diseaseprimary ciliary dyskinesia (implicated_via_orthology)

PCSK5 SLIT2

1.39e-0319862DOID:9562 (implicated_via_orthology)
Diseaselung non-small cell carcinoma (is_marker_for)

UBR5 BIRC2 SPOP ITGB3

1.53e-03169864DOID:3908 (is_marker_for)
Diseaseglomerulonephritis (biomarker_via_orthology)

LTBP1 ITGB3

1.54e-0320862DOID:2921 (biomarker_via_orthology)
Diseasetrauma exposure measurement

NRXN3 LTBP1 LRP1B TENM2

1.63e-03172864EFO_0010703
DiseaseX-24947 measurement

SLC17A1 UGT2B7

1.87e-0322862EFO_0800910
Diseaseprogranulin measurement

CELSR2 GRN

1.87e-0322862EFO_0004625
DiseaseLiver Cirrhosis, Experimental

SLC17A2 SLC17A1 GRN LTBP1 ITGB3 ITGB6 CTSS PLAC8

1.90e-03774868C0023893
DiseaseAutism Spectrum Disorders

NRXN3 NRXN1 ITGB3

1.99e-0385863C1510586
DiseaseRenal glomerular disease

SLC12A3 CRB2

2.04e-0323862C0268731
DiseaseGlomerulopathy Assessment

SLC12A3 CRB2

2.04e-0323862C4521256
DiseaseCarcinoma, Pancreatic Ductal

JAG2 NOTCH4

2.22e-0324862C0887833
Diseasetemperament and character inventory

NRXN1 TG

2.22e-0324862EFO_0004825
Diseasecreatinine measurement

TINAGL1 JAG2 HGFAC CELSR3 CELSR2 CUBN PLXNB2 CTSS PSD4

2.45e-03995869EFO_0004518
Diseasebody surface area

PCSK5 NRXN3 LTBP1 LTBP2 ITGB3 ITGB8 PSD4

2.75e-03643867EFO_0022196
Diseaseretinitis pigmentosa (implicated_via_orthology)

EYS CRB2

2.81e-0327862DOID:10584 (implicated_via_orthology)
Diseasecaudate volume change measurement, age at assessment

NRXN3 NRXN1

2.81e-0327862EFO_0008007, EFO_0021491

Protein segments in the cluster

PeptideGeneStartEntry
ECSQSWDTFSCDCLG

CNTNAP3

561

Q9BZ76
CSNEATCICDFTWAG

ADAM23

751

O75077
TCICDFTWAGTDCSI

ADAM23

756

O75077
SLAIFCWSFQGGCVS

C8orf44

106

Q96CB5
CIFDKFECCWNGSDS

PPP2R2A

341

P63151
SGAWGCCPFTQAVCC

GRN

301

P28799
CGHDFCRGCWESFLN

ANKIB1

351

Q9P2G1
SCSFTGCWCCRGDDV

ANKRD26P1

16

Q6NSI1
GGTCVNQWDAFSCEC

CELSR2

1586

Q9HCU4
SSDCIEGFCCARHFW

DKK2

186

Q9UBU2
CFQVTWTGGSRCFSC

RASAL3

261

Q86YV0
GCQFFITCSKCDWLD

PPIH

121

O43447
LSCLEFFCRWQGCGD

APOLD1

166

Q96LR9
CTCQVGFTGKECQWT

NOTCH2NLB

131

P0DPK3
CTCQVGFTGKECQWT

NOTCH2

131

Q04721
DCVSSRFWCDGDFDC

LRP1B

3526

Q9NZR2
SVYCNCTTGWKGSFC

EYS

2631

Q5T1H1
QAVWSCSGCFCIFHM

NFXL1

171

Q6ZNB6
CFNGGTCLVTWNDFH

CRB2

816

Q5IJ48
GGICVDGVNWFRCEC

JAG2

801

Q9Y219
SVCLGTRQCSWFAGC

ERVMER34-1

176

Q9H9K5
CSDGTCDGCNFHFLW

ELAPOR1

836

Q6UXG2
LCFPSVGHCQWFCGL

MAP3K6

601

O95382
SCDQNGCYWCEEGFF

PCSK5

1091

Q92824
CWTCGCGTDTNFEVK

PLSCR3

211

Q9NRY6
WCGGQSRCVYEALCN

PLXNB2

781

O15031
GECVCRSGWTGEYCN

ITGB6

561

P18564
CCGTVGTSWGFNKCQ

LTBP1

581

Q14766
TVAWCCGFLNSFIMC

OR2W5P

146

A6NFC9
WGSITCIICFTCVGS

FBXW7-AS1

16

B0L3A2
ICDCTGTGYWGRTCE

NRXN3

666

Q9Y4C0
YSSCLGCLADQGCGW

MEGF8

851

Q7Z7M0
GVCLQQWDGFSCDCS

NRXN1

1096

Q9ULB1
EQCECFGGRTWCEGT

HGFAC

226

Q04756
ECEAGRCQCFSGWEG

ITGB8

566

P26012
CACGYGCGSWDVQLE

RETNLB

76

Q9BQ08
YFCKCDSGWTGVNCT

CUBN

416

O60494
RWCAEGGNLICCDFC

ATRX

221

P46100
FSGLAQSGAWCCFDE

DNAH6

1511

Q9C0G6
FCCFEDCRTGSWREG

GABRG1

416

Q8N1C3
TFWPCFELCCLDSFG

IGFL2

71

Q6UWQ7
GCFCLCWAPFFVTNI

HTR4

266

Q13639
CCGSVGAFWGVTLCA

LTBP2

576

Q14767
CCCTQGASWGDACDL

LTBP2

1436

Q14767
GQCSCGDCLCDSDWT

ITGB3

566

P05106
CVTEVKYQGSCGACW

CTSS

126

P25774
CGACWAFSAVGALEA

CTSS

136

P25774
FCCFAWLCFPISLGS

GDF9

11

O60383
FCSERWGSFSCDCPV

CELSR3

1736

Q9NYQ7
EEEFSCLWQECGFCS

HINFP

61

Q9BQA5
CLWQECGFCSLDSSA

HINFP

66

Q9BQA5
ECSQSWDTFSCDCLG

CNTNAP3B

561

Q96NU0
AVGFCVECGEWLCKT

TRIM33

226

Q9UPN9
VSDCCPDFWDFCLGV

TINAGL1

81

Q9GZM7
AGPRWEAFCCNSCGA

SMYD4

611

Q8IYR2
GIDSTCLFWSTFCGE

SLCO3A1

596

Q9UIG8
CLFWSTFCGEQGACV

SLCO3A1

601

Q9UIG8
GACGCAVCLLWFVLF

SLC17A1

206

Q14916
CSENSASGECFSWGA

PSD4

256

Q8NDX1
PEACFTDGCVWRFSC

SCN9A

1151

Q15858
NCGHLFCGACIIAYW

RNF170

101

Q96K19
GCFQNLTCSVPWACE

SIGLEC7

161

Q9Y286
WHPGFNCEFFTFCCG

SHISA4

41

Q96DD7
TCQCYSGWKGAECDV

TENM2

621

Q9NT68
CGFLFSGADSAWCQT

MRGPRX1

161

Q96LB2
ADTGEFSCWVQLCSG

PDGFRL

136

Q15198
CVCVSGWGGTSCEEN

NOTCH4

341

Q99466
EAIWCHQCTGFGGCS

SLURP2

21

P0DP57
CFCCDGGLRCWESGD

BIRC2

306

Q13490
DNVSGEFGWSFCLAC

CLDND1

206

Q9NY35
YCTLLDCLCSWGQVG

NCAPG2

706

Q86XI2
GAWCSLCTASVSGCF

CLEC18A

201

A5D8T8
GAWCSLCTASVSGCF

CLEC18B

201

Q6UXF7
GAWCSLCTASVSGCF

CLEC18C

201

Q8NCF0
FWVDLDCQIFCYCSG

TECTA

1051

O75443
LWFAIGLACAGFCCH

ZDHHC22

191

Q8N966
VCAASGDFWVLVGYC

SLC16A5

321

O15375
WCNGCFCGLGLVSTN

RNF122

6

Q9H9V4
VCFSCCSDGNIAVWD

TLE4

591

Q04727
GGLWENSRFTDCCLC

SPOP

191

O43791
GCCFDSSVTGVPWCF

TFF2

56

Q03403
FGSTGCVCCLLWFTV

SLC17A2

216

O00624
FSFESCGCICNEGWF

TNR

181

Q92752
CEGLACSYGWNFTEC

SLC12A3

416

P55017
GTCCCAGWLDVFYNG

SCART1

666

Q4G0T1
GFWCICADGFEGENC

SLIT2

981

O94813
CFFGESFCICDGTVW

TEX50

16

A0A1B0GTY4
CFSCCSDGNIAVWDL

TLE3

591

Q04726
CWSLGQCGGVFLSCT

VPS13B

1391

Q7Z7G8
WQTGMCDCFSDCGVC

PLAC8

26

Q9NZF1
VCCIQYSGDGQWLAC

WDR27

516

A2RRH5
FCFSSGNCGKVLVWA

UGT2B7

16

P16662
CFSGECWCVNSWGKE

TG

631

P01266
GQCVRTCWGCGSVAC

SIVA1

136

O15304
LWACLENRCSYVGCG

USP33

71

Q8TEY7
YNCNVCGKGFRWSSC

ZNF284

371

Q2VY69
YVLCCNDTCSFTWTG

UBR5

1171

O95071
SQGCTNSEGAFQCWC

LRP4

406

O75096