Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme activity	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	5.54e-06	37	139	5	GO:0061631
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme activity	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.18e-05	43	139	5	GO:0061650
GeneOntologyMolecularFunction	(R)-limonene 6-monooxygenase activity	CYP2C19 CYP2C9	4.81e-05	2	139	2	GO:0052741
GeneOntologyMolecularFunction	(S)-limonene 6-monooxygenase activity	CYP2C19 CYP2C9	4.81e-05	2	139	2	GO:0018675
GeneOntologyMolecularFunction	(S)-limonene 7-monooxygenase activity	CYP2C19 CYP2C9	4.81e-05	2	139	2	GO:0018676
GeneOntologyMolecularFunction	limonene monooxygenase activity	CYP2C19 CYP2C9	4.81e-05	2	139	2	GO:0019113
GeneOntologyMolecularFunction	arachidonate 11,12-epoxygenase activity	CYP2C19 CYP2C9	2.86e-04	4	139	2	GO:0008405
GeneOntologyMolecularFunction	linoleic acid epoxygenase activity	CYP2C19 CYP2C9	2.86e-04	4	139	2	GO:0071614
GeneOntologyMolecularFunction	fatty acid omega-1 hydroxylase activity	CYP2C19 CYP2C9	4.75e-04	5	139	2	GO:0120502
GeneOntologyMolecularFunction	long-chain fatty acid omega-1 hydroxylase activity	CYP2C19 CYP2C9	4.75e-04	5	139	2	GO:0120319
GeneOntologyMolecularFunction	arachidonate 14,15-epoxygenase activity	CYP2C19 CYP2C9	4.75e-04	5	139	2	GO:0008404
GeneOntologyMolecularFunction	sulfatide binding	PPT1 TPP1	7.09e-04	6	139	2	GO:0120146
GeneOntologyMolecularFunction	prolactin receptor binding	GH1 GH2	9.87e-04	7	139	2	GO:0005148
GeneOntologyMolecularFunction	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor	CYP2C19 CYP2C9	1.31e-03	8	139	2	GO:0033695
GeneOntologyMolecularFunction	lysophosphatidic acid binding	PPT1 TPP1	1.31e-03	8	139	2	GO:0035727
GeneOntologyMolecularFunction	caffeine oxidase activity	CYP2C19 CYP2C9	1.31e-03	8	139	2	GO:0034875
GeneOntologyMolecularFunction	phospholipid binding	ADGRB1 SNX19 ASAP1 ITPR3 PPT1 TPP1 PAFAH2 OSBPL5 ZFYVE26 ACAP2 RPE65	1.59e-03	548	139	11	GO:0005543
GeneOntologyMolecularFunction	phosphatidylserine binding	ADGRB1 ASAP1 OSBPL5 RPE65	1.69e-03	73	139	4	GO:0001786
Domain	-	SEMA6C SEMA4B IFT140 STRN3 DMXL2 WDR31 WDR18 BIRC6 ERCC8 AAAS NBEAL2 WDR90	8.63e-06	333	141	12	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	SEMA6C SEMA4B IFT140 STRN3 DMXL2 WDR31 WDR18 BIRC6 ERCC8 AAAS NBEAL2 WDR90	9.17e-06	335	141	12	IPR015943
Domain	UQ_con	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.07e-05	39	141	5	PF00179
Domain	UBIQUITIN_CONJUGAT_1	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.21e-05	40	141	5	PS00183
Domain	UBIQUITIN_CONJUGAT_2	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.38e-05	41	141	5	PS50127
Domain	UBQ-conjugat_E2	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.38e-05	41	141	5	IPR000608
Domain	UBQ-conjugating_AS	UBE2D1 UBE2D2 UBE2D3 UBE2D4	3.48e-05	25	141	4	IPR023313
Domain	-	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	4.06e-05	51	141	5	3.10.110.10
Domain	UBQ-conjugating_enzyme/RWD	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	4.90e-05	53	141	5	IPR016135
Domain	WD40	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	1.57e-04	259	141	9	PF00400
Domain	WD40	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	2.03e-04	268	141	9	SM00320
Domain	WD40_repeat	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	2.27e-04	272	141	9	IPR001680
Domain	WD_REPEATS_1	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	2.66e-04	278	141	9	PS00678
Domain	WD_REPEATS_2	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	2.73e-04	279	141	9	PS50082
Domain	WD_REPEATS_REGION	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	2.73e-04	279	141	9	PS50294
Domain	-	DAGLB TG NLGN3 PPT1 PAFAH2 LYPLA1	2.87e-04	119	141	6	3.40.50.1820
Domain	AB_hydrolase	DAGLB TG NLGN3 PPT1 PAFAH2 LYPLA1	2.87e-04	119	141	6	IPR029058
Domain	WD40_repeat_dom	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	4.32e-04	297	141	9	IPR017986
Domain	Somatotropin_CS	GH1 GH2	5.58e-04	5	141	2	IPR018116
Domain	Ig_I-set	UNC5B L1CAM CEACAM21 LINGO4 KDR ROBO3 SDK1	6.06e-04	190	141	7	IPR013098
Domain	I-set	UNC5B L1CAM CEACAM21 LINGO4 KDR ROBO3 SDK1	6.06e-04	190	141	7	PF07679
Domain	SOMATOTROPIN_2	GH1 GH2	8.32e-04	6	141	2	PS00338
Domain	SOMATOTROPIN_1	GH1 GH2	8.32e-04	6	141	2	PS00266
Domain	Hormone_1	GH1 GH2	8.32e-04	6	141	2	PF00103
Domain	ARM-type_fold	HEATR5A MEI1 NCDN ARFGEF3 HEATR6 PSME4 NBEAL2 IFRD2 MMS19	1.10e-03	339	141	9	IPR016024
Domain	Somatotropin	GH1 GH2	1.16e-03	7	141	2	IPR001400
Domain	ArfGap	ASAP1 ACAP2 ACAP3	1.33e-03	29	141	3	SM00105
Domain	ARFGAP	ASAP1 ACAP2 ACAP3	1.33e-03	29	141	3	PS50115
Domain	ArfGap	ASAP1 ACAP2 ACAP3	1.33e-03	29	141	3	PF01412
Domain	ArfGAP	ASAP1 ACAP2 ACAP3	1.33e-03	29	141	3	IPR001164
Domain	IG	UNC5B L1CAM CEACAM3 LAG3 CEACAM21 LINGO4 KDR CTLA4 ROBO3 SDK1	1.37e-03	421	141	10	SM00409
Domain	Ig_sub	UNC5B L1CAM CEACAM3 LAG3 CEACAM21 LINGO4 KDR CTLA4 ROBO3 SDK1	1.37e-03	421	141	10	IPR003599
Domain	AH/BAR-dom	ASAP1 ACAP2 ACAP3	1.47e-03	30	141	3	IPR027267
Domain	-	ASAP1 ACAP2 ACAP3	1.47e-03	30	141	3	1.20.1270.60
Domain	WD40_repeat_CS	STRN3 WDR31 WDR18 ERCC8 AAAS WDR90	1.55e-03	164	141	6	IPR019775
Domain	HEAT_REPEAT	HEATR5A HEATR6 PSME4 MMS19	1.94e-03	70	141	4	PS50077
Domain	IGc2	UNC5B L1CAM CEACAM21 LINGO4 KDR ROBO3 SDK1	2.07e-03	235	141	7	SM00408
Domain	Ig_sub2	UNC5B L1CAM CEACAM21 LINGO4 KDR ROBO3 SDK1	2.07e-03	235	141	7	IPR003598
Domain	G-protein_beta_WD-40_rep	STRN3 WDR31 WDR18 ERCC8	3.93e-03	85	141	4	IPR020472
Domain	IG_LIKE	UNC5B L1CAM CEACAM3 LAG3 CEACAM21 LINGO4 KDR CTLA4 ROBO3 SDK1	4.14e-03	491	141	10	PS50835
Domain	I-BAR_dom	ASAP1 ACAP3	4.18e-03	13	141	2	IPR013606
Domain	Carboxylesterase_B_CS	TG NLGN3	4.18e-03	13	141	2	IPR019819
Domain	ARM-like	HEATR5A MEI1 HEATR6 PSME4 NBEAL2 IFRD2 MMS19	4.46e-03	270	141	7	IPR011989
Domain	CARBOXYLESTERASE_B_2	TG NLGN3	4.85e-03	14	141	2	PS00941
Domain	COesterase	TG NLGN3	4.85e-03	14	141	2	PF00135
Domain	CarbesteraseB	TG NLGN3	4.85e-03	14	141	2	IPR002018
Domain	Ig-like_dom	UNC5B L1CAM CEACAM3 LAG3 CEACAM21 LINGO4 KDR CTLA4 ROBO3 SDK1	4.90e-03	503	141	10	IPR007110
Domain	Ig-like_fold	SEMA4B UNC5B L1CAM CEACAM3 LAG3 CEACAM21 LINGO4 KDR CTLA4 ROBO3 SDK1 IL27RA	7.28e-03	706	141	12	IPR013783
Domain	Quinoprotein_ADH-like_supfam	SEMA6C DMXL2 WDR90	7.49e-03	53	141	3	IPR011047
Pubmed	Inhibition of UVSSA ubiquitination suppresses transcription-coupled nucleotide excision repair deficiency caused by dissociation from USP7.	ERCC8 UBE2D1 UBE2D2 UBE2D3 UBE2D4	6.29e-11	8	144	5	29323787
Pubmed	h-Goliath, paralog of GRAIL, is a new E3 ligase protein, expressed in human leukocytes.	RNF130 UBE2D1 UBE2D2 UBE2D3	4.20e-09	6	144	4	16549277
Pubmed	The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	9.77e-09	7	144	4	21685362
Pubmed	Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	9.77e-09	7	144	4	30884854
Pubmed	Ube2W conjugates ubiquitin to α-amino groups of protein N-termini.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.95e-08	8	144	4	23560854
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SEMA6C SEMA4B SPHK2 MRPS12 PIEZO1 L1CAM BIRC6 KIAA2013 ITPR3 CNPPD1 EFNA2 PSME4 DNAJC14 NBEAL2 IFRD2 OSBPL5 PYGB ZFYVE26 HMGXB3 WDR90	3.38e-08	1105	144	20	35748872
Pubmed	Mechanism and chain specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon Holmes syndrome.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	5.81e-08	10	144	4	31087003
Pubmed	Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	5.81e-08	10	144	4	28757353
Pubmed	The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function.	UBE2D1 UBE2D2 KDR	6.95e-08	3	144	3	37226882
Pubmed	Identification of a family of closely related human ubiquitin conjugating enzymes.	UBE2D1 UBE2D2 UBE2D3	6.95e-08	3	144	3	8530467
Pubmed	The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.36e-07	12	144	4	24211586
Pubmed	Ubiquitination of STING at lysine 224 controls IRF3 activation.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.96e-07	13	144	4	28763789
Pubmed	Divergent self-association properties of paralogous proteins TRIM2 and TRIM3 regulate their E3 ligase activity.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	2.73e-07	14	144	4	36481767
Pubmed	Physical and functional interactions between ZIP kinase and UbcH5.	UBE2D1 UBE2D2 UBE2D3	2.77e-07	4	144	3	18515077
Pubmed	Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	6.43e-07	17	144	4	33650289
Pubmed	Elucidation of ubiquitin-conjugating enzymes that interact with RBR-type ubiquitin ligases using a liquid-liquid phase separation-based method.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	6.43e-07	17	144	4	36563856
Pubmed	Non-response to antiepileptic pharmacotherapy is associated with the ABCC2 -24C>T polymorphism in young and adult patients with epilepsy.	CYP2C19 CYP2C9 ABCC2	6.91e-07	5	144	3	19415824
Pubmed	E3 ubiquitin ligase activity of the trifunctional ARD1 (ADP-ribosylation factor domain protein 1).	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	15684077
Pubmed	Systematic E2 screening reveals a UBE2D-RNF138-CtIP axis promoting DNA repair.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	26502057
Pubmed	Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	25327252
Pubmed	The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	14562029
Pubmed	Tripartite motif ligases catalyze polyubiquitin chain formation through a cooperative allosteric mechanism.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	23408431
Pubmed	Mitochondrial ubiquitin ligase MITOL ubiquitinates mutant SOD1 and attenuates mutant SOD1-induced reactive oxygen species generation.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	19741096
Pubmed	Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	8090726
Pubmed	ADP-ribosylation factor domain protein 1 (ARD1), a multifunctional protein with ubiquitin E3 ligase, GAP, and ARF domains.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	16413270
Pubmed	The RING domain of mitochondrial E3 ubiquitin ligase 1 and its complex with Ube2D2: crystallization and X-ray diffraction.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	31929179
Pubmed	Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis.	UBE2D1 UBE2D2 UBE2D3	6.91e-07	5	144	3	23509263
Pubmed	Synthesis of Isomeric Phosphoubiquitin Chains Reveals that Phosphorylation Controls Deubiquitinase Activity and Specificity.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.04e-06	19	144	4	27425610
Pubmed	Fbxl17 is rearranged in breast cancer and loss of its activity leads to increased global O-GlcNAcylation.	RLF UBE2D1 UBE2D2 UBE2D3 PSME4	1.36e-06	46	144	5	31560077
Pubmed	Positive regulation of p53 stability and activity by the deubiquitinating enzyme Otubain 1.	UBE2D1 UBE2D2 UBE2D3	1.38e-06	6	144	3	22124327
Pubmed	The E3 ubiquitin ligase TRIM32 regulates myoblast proliferation by controlling turnover of NDRG2.	UBE2D1 UBE2D2 UBE2D3	1.38e-06	6	144	3	25701873
Pubmed	Znf179 E3 ligase-mediated TDP-43 polyubiquitination is involved in TDP-43- ubiquitinated inclusions (UBI) (+)-related neurodegenerative pathology.	UBE2D1 UBE2D2 UBE2D3	1.38e-06	6	144	3	30404641
Pubmed	Role of E2-RING Interactions in Governing RNF4-Mediated Substrate Ubiquitination.	UBE2D1 UBE2D2 UBE2D3	1.38e-06	6	144	3	27678051
Pubmed	Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo.	UBE2D1 UBE2D2 UBE2D3	1.38e-06	6	144	3	15280377
Pubmed	Negative regulation of the RLH signaling by the E3 ubiquitin ligase RNF114.	UBE2D1 UBE2D2 UBE2D3	1.38e-06	6	144	3	28625874
Pubmed	NEDD4 regulates ubiquitination and stability of the cell adhesion molecule IGPR-1 via lysosomal pathway.	UBE2D1 UBE2D2 UBE2D3	1.38e-06	6	144	3	33962630
Pubmed	Defining the membrane proteome of NK cells.	RCE1 CPT1A BIRC6 NCDN KIAA2013 ITPR3 AAAS DNAJC14 GTF3C1 PPT1 NBEAL2 OSBPL5 PYGB CHPF2 MMS19 ACAP2 PIGO ADPGK	1.75e-06	1168	144	18	19946888
Pubmed	The MALDI-TOF E2/E3 Ligase Assay as Universal Tool for Drug Discovery in the Ubiquitin Pathway.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	2.35e-06	23	144	4	30017913
Pubmed	A ubiquitin ligase complex assembles linear polyubiquitin chains.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	17006537
Pubmed	Lys-63-linked ubiquitination by E3 ubiquitin ligase Nedd4-1 facilitates endosomal sequestration of internalized α-synuclein.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	24831002
Pubmed	UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	17719635
Pubmed	A molecular circuit composed of CPEB-1 and c-Jun controls growth hormone-mediated synaptic plasticity in the mouse hippocampus.	GH1 GH2 CPEB1	2.40e-06	7	144	3	18716208
Pubmed	RNF122: a novel ubiquitin ligase associated with calcium-modulating cyclophilin ligand.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	20553626
Pubmed	The E3 ubiquitin ligase MID1 catalyzes ubiquitination and cleavage of Fu.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	25278022
Pubmed	Priming and extending: a UbcH5/Cdc34 E2 handoff mechanism for polyubiquitination on a SCF substrate.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	20347421
Pubmed	Lysine 63-linked polyubiquitination of the dopamine transporter requires WW3 and WW4 domains of Nedd4-2 and UBE2D ubiquitin-conjugating enzymes.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	20051513
Pubmed	Measuring rates of ubiquitin chain formation as a functional readout of ligase activity.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	22350887
Pubmed	In Vitro Analysis of E3 Ubiquitin Ligase Function.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	34057440
Pubmed	The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.	UBE2D1 UBE2D2 UBE2D3	2.40e-06	7	144	3	33282879
Pubmed	Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	2.81e-06	24	144	4	24647965
Pubmed	Reconstitution of human CMG helicase ubiquitylation by CUL2LRR1 and multiple E2 enzymes.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	2.81e-06	24	144	4	34195792
Pubmed	Structure and catalytic activation of the TRIM23 RING E3 ubiquitin ligase.	UBE2D2 UBE2D3 UBE2D4	3.83e-06	8	144	3	28681414
Pubmed	The mechanism of neural precursor cell expressed developmentally down-regulated 4-2 (Nedd4-2)/NEDD4L-catalyzed polyubiquitin chain assembly.	UBE2D1 UBE2D2 UBE2D3	3.83e-06	8	144	3	28972136
Pubmed	Hypoxia-associated factor, a novel E3-ubiquitin ligase, binds and ubiquitinates hypoxia-inducible factor 1alpha, leading to its oxygen-independent degradation.	UBE2D1 UBE2D2 UBE2D3	3.83e-06	8	144	3	18838541
Pubmed	MID1 catalyzes the ubiquitination of protein phosphatase 2A and mutations within its Bbox1 domain disrupt polyubiquitination of alpha4 but not of PP2Ac.	UBE2D1 UBE2D2 UBE2D3	3.83e-06	8	144	3	25207814
Pubmed	A novel route for F-box protein-mediated ubiquitination links CHIP to glycoprotein quality control.	UBE2D1 UBE2D2 UBE2D3	3.83e-06	8	144	3	16682404
Pubmed	The BAL-binding protein BBAP and related Deltex family members exhibit ubiquitin-protein isopeptide ligase activity.	UBE2D1 UBE2D2 UBE2D3	3.83e-06	8	144	3	12670957
Pubmed	Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.	UBE2D1 UBE2D2 UBE2D3	3.83e-06	8	144	3	15247280
Pubmed	Cbl-c suppresses v-Src-induced transformation through ubiquitin-dependent protein degradation.	UBE2D1 UBE2D2 UBE2D3	3.83e-06	8	144	3	14661060
Pubmed	The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	3.93e-06	26	144	4	20061386
Pubmed	Functional interactions between ubiquitin E2 enzymes and TRIM proteins.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	4.59e-06	27	144	4	21143188
Pubmed	Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay.	UBE2D1 UBE2D2 UBE2D3 UBE2D4	4.59e-06	27	144	4	30097011
Pubmed	Negative Regulation of CARD11 Signaling and Lymphoma Cell Survival by the E3 Ubiquitin Ligase RNF181.	UBE2D1 UBE2D2 UBE2D3	5.73e-06	9	144	3	26711259
Pubmed	Cellular inhibitor of apoptosis 1 and 2 are ubiquitin ligases for the apoptosis inducer Smac/DIABLO.	UBE2D1 UBE2D2 UBE2D3	5.73e-06	9	144	3	12525502
Pubmed	Negative regulation of the RIG-I signaling by the ubiquitin ligase RNF125.	UBE2D1 UBE2D2 UBE2D3	5.73e-06	9	144	3	17460044
Pubmed	Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.	UBE2D1 UBE2D2 UBE2D3	5.73e-06	9	144	3	32049508
Pubmed	TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase.	UBE2D1 UBE2D2 UBE2D3	5.73e-06	9	144	3	17544371
Pubmed	Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis.	USP30 UBE2D1 UBE2D3 UBE2D4	8.13e-06	31	144	4	25527291
Pubmed	Inflammasome activation and metabolic remodelling in p16-positive aging cells aggravates high-fat diet-induced lung fibrosis by inhibiting NEDD4L-mediated K48-polyubiquitin-dependent degradation of SGK1.	UBE2D1 UBE2D2 UBE2D3	8.17e-06	10	144	3	37345264
Pubmed	Bag1 directly routes immature BCR-ABL for proteasomal degradation.	UBE2D1 UBE2D2 UBE2D3	8.17e-06	10	144	3	20675402
Pubmed	E2 conjugating enzyme selectivity and requirements for function of the E3 ubiquitin ligase CHIP.	UBE2D1 UBE2D2 UBE2D3	8.17e-06	10	144	3	21518764
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	SFXN4 CYP2C9 SLC16A9 UNC5B CALHM3 UBE2D1 MMS19 ZNF488 ABCC2 CFAP46	9.75e-06	415	144	10	16385451
Pubmed	A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.	RNF130 TRIM65 UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.02e-05	118	144	6	19690564
Pubmed	A dimer-monomer switch controls CHIP-dependent substrate ubiquitylation and processing.	UBE2D1 UBE2D2 UBE2D3	1.12e-05	11	144	3	36027913
Pubmed	Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.	UBE2D1 UBE2D2 UBE2D3	1.12e-05	11	144	3	24438103
Pubmed	Dynamic interactions of proteins in complex networks: identifying the complete set of interacting E2s for functional investigation of E3-dependent protein ubiquitination.	UBE2D1 UBE2D2 UBE2D3	1.12e-05	11	144	3	19712108
Pubmed	Monoubiquitinated histone H2A destabilizes photolesion-containing nucleosomes with concomitant release of UV-damaged DNA-binding protein E3 ligase.	UBE2D1 UBE2D2 UBE2D3	1.12e-05	11	144	3	22334663
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SEMA6C IFT140 PIEZO1 NUDCD3 PSME4 NBEAL2 OSBPL5 HMGXB3 WDR90 ACAP2 ACAP3	1.38e-05	529	144	11	14621295
Pubmed	Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding.	UBE2D1 UBE2D2 UBE2D3	1.49e-05	12	144	3	24905733
Pubmed	E1-E2 interactions in ubiquitin and Nedd8 ligation pathways.	UBE2D1 UBE2D2 UBE2D3	1.49e-05	12	144	3	22069333
Pubmed	Accumulation of p53 via down-regulation of UBE2D family genes is a critical pathway for cadmium-induced renal toxicity.	UBE2D2 UBE2D4	1.70e-05	2	144	2	26912277
Pubmed	Neuronal ceroid lipofuscinoses caused by defects in soluble lysosomal enzymes (CLN1 and CLN2).	PPT1 TPP1	1.70e-05	2	144	2	12125808
Pubmed	Important amino acid residues that confer CYP2C19 selective activity to CYP2C9.	CYP2C19 CYP2C9	1.70e-05	2	144	2	18511451
Pubmed	Association of Cytotoxic T-Lymphocyte Antigen 4 (CTLA4) and Thyroglobulin (TG) Genetic Variants with Autoimmune Hypothyroidism.	TG CTLA4	1.70e-05	2	144	2	26963610
Pubmed	Developmental expression of human hepatic CYP2C9 and CYP2C19.	CYP2C19 CYP2C9	1.70e-05	2	144	2	14634042
Pubmed	Association study of early-immediate genes in childhood-onset mood disorders and suicide attempt.	NPTX2 GRM1	1.70e-05	2	144	2	22460132
Pubmed	NBEAL2 deficiency in humans leads to low CTLA-4 expression in activated conventional T cells.	NBEAL2 CTLA4	1.70e-05	2	144	2	37349339
Pubmed	CYP2C40, a unique arachidonic acid 16-hydroxylase, is the major CYP2C in murine intestinal tract.	CYP2C19 CYP2C9	1.70e-05	2	144	2	10908295
Pubmed	Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme.	CYP2C19 CYP2C9	1.70e-05	2	144	2	1847130
Pubmed	Cytochromes P450 catalyze oxidation of alpha,beta-unsaturated aldehydes.	CYP2C19 CYP2C9	1.70e-05	2	144	2	17599801
Pubmed	Dosage recommendation of phenytoin for patients with epilepsy with different CYP2C9/CYP2C19 polymorphisms.	CYP2C19 CYP2C9	1.70e-05	2	144	2	15385837
Pubmed	[Effect of original and generic clopidogrel on prognosis in relation to different gene polymorphisms].	CYP2C19 CYP2C9	1.70e-05	2	144	2	25518510
Pubmed	The predictive value of CTLA-4 and Tg polymorphisms in the recurrence of Graves' disease after antithyroid withdrawal.	TG CTLA4	1.70e-05	2	144	2	17526951
Pubmed	Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.	CYP2C19 CYP2C9	1.70e-05	2	144	2	15842554
Pubmed	Rapid identification of the hepatic cytochrome P450 2C19 activity using a novel and noninvasive [13C]pantoprazole breath test.	CYP2C19 CYP2C9	1.70e-05	2	144	2	19136640
Pubmed	Mouse Cyp2c expression and zonation structure in the liver begins in the early neonatal stage.	CYP2C19 CYP2C9	1.70e-05	2	144	2	35748067
Pubmed	Time serial transcriptome reveals Cyp2c29 as a key gene in hepatocellular carcinoma development.	CYP2C19 CYP2C9	1.70e-05	2	144	2	32587777
Pubmed	Genetic polymorphisms of cytochrome P450 enzymes 2C9 and 2C19 in a healthy Iranian population.	CYP2C19 CYP2C9	1.70e-05	2	144	2	17201743
Pubmed	CYP2C9 (2&3) and CYP2C19 (2&3) polymorphisms among children with nonlesional epilepsy: a single-center study.	CYP2C19 CYP2C9	1.70e-05	2	144	2	32683556
Pubmed	Evaluation of phenytoin dosage regimens based on genotyping of CYP2C subfamily in routinely treated Japanese patients.	CYP2C19 CYP2C9	1.70e-05	2	144	2	15855721
Interaction	UVSSA interactions	ERCC8 AAAS UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.97e-07	37	140	6	int:UVSSA
Interaction	ARK2C interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.06e-06	12	140	4	int:ARK2C
Interaction	RNF150 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	9.91e-06	20	140	4	int:RNF150
Interaction	UBOX5 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.78e-05	23	140	4	int:UBOX5
Interaction	TRIM3 interactions	NCDN UBE2D1 UBE2D2 UBE2D3 UBE2D4 ASL	1.99e-05	80	140	6	int:TRIM3
Interaction	TRIM10 interactions	IFT140 UBE2D1 UBE2D2 UBE2D3 UBE2D4	2.03e-05	48	140	5	int:TRIM10
Interaction	TRIM2 interactions	NCDN UBE2D1 UBE2D2 UBE2D3 UBE2D4	3.31e-05	53	140	5	int:TRIM2
Interaction	NTF3 interactions	ITIH3 HARS2 PYGB KCTD18	3.46e-05	27	140	4	int:NTF3
Interaction	MYLIP interactions	VLDLR UBE2D1 UBE2D2 UBE2D3 UBE2D4	4.33e-05	56	140	5	int:MYLIP
Interaction	RNF103 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	4.63e-05	29	140	4	int:RNF103
Interaction	CADPS2 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	5.31e-05	30	140	4	int:CADPS2
Interaction	TRIM62 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	6.90e-05	32	140	4	int:TRIM62
Interaction	BIRC8 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	6.90e-05	32	140	4	int:BIRC8
Interaction	TRIM45 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	7.81e-05	33	140	4	int:TRIM45
Interaction	TRIM17 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	8.80e-05	34	140	4	int:TRIM17
Interaction	NRP1 interactions	SEMA6C SEMA4B MRPS12 L1CAM AAAS OSBPL5 KDR MMS19 CTLA4 IL27RA	9.11e-05	324	140	10	int:NRP1
Interaction	DTX1 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	9.88e-05	35	140	4	int:DTX1
Interaction	ZNRF1 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.11e-04	36	140	4	int:ZNRF1
Interaction	ZNRF4 interactions	KIAA2013 ITPR3 UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.20e-04	110	140	6	int:ZNRF4
Interaction	UBTD1 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	1.68e-04	40	140	4	int:UBTD1
Interaction	RNF122 interactions	UBE2D1 UBE2D2 UBE2D3	1.72e-04	16	140	3	int:RNF122
Interaction	MARCHF7 interactions	TRIM65 UBE2D1 UBE2D2 UBE2D3 KLHL34	2.12e-04	78	140	5	int:MARCHF7
Interaction	ANAPC11 interactions	TRIM65 BIRC6 UBE2D1 UBE2D2 UBE2D3	2.12e-04	78	140	5	int:ANAPC11
Interaction	RNF25 interactions	UBE2D1 UBE2D2 UBE2D3 UBE2D4	2.23e-04	43	140	4	int:RNF25
Interaction	MARCHF3 interactions	UBE2D2 UBE2D3 UBE2D4 CHPF2	2.23e-04	43	140	4	int:MARCHF3
Cytoband	10q24	CYP2C19 CYP2C9 ABCC2	1.84e-04	35	144	3	10q24
GeneFamily	Ubiquitin conjugating enzymes E2	BIRC6 UBE2D1 UBE2D2 UBE2D3 UBE2D4	2.85e-06	41	99	5	102
GeneFamily	WD repeat domain containing	IFT140 STRN3 DMXL2 WDR31 WDR18 ERCC8 AAAS NBEAL2 WDR90	1.36e-05	262	99	9	362
GeneFamily	X-linked mental retardation\|Rho GTPase activating proteins\|BAR-PH domain containing	ASAP1 ACAP2 ACAP3	1.02e-04	17	99	3	1291
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	UNC5B L1CAM LINGO4 KDR ROBO3 SDK1	2.57e-04	161	99	6	593
GeneFamily	Growth hormone family	GH1 GH2	4.39e-04	6	99	2	1175
GeneFamily	ArfGAPs	ASAP1 ACAP2 ACAP3	7.71e-04	33	99	3	395
GeneFamily	G protein-coupled receptors, Class A orphans	GPR15 GPR22 GPR149 GPR75	8.85e-04	78	99	4	262
GeneFamily	Immunoglobulin like domain containing	LAG3 CEACAM21 KDR ROBO3 SDK1	4.19e-03	193	99	5	594
GeneFamily	Immunoglobulin like domain containing\|Semaphorins	SEMA6C SEMA4B	5.29e-03	20	99	2	736
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	ASAP1 OSBPL5 ACAP2 ACAP3 FGD3	5.51e-03	206	99	5	682
GeneFamily	F-box and leucine rich repeat proteins	FBXL4 KDM2A	5.82e-03	21	99	2	558
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGZ PIGO	5.82e-03	21	99	2	680
ToppCell	COVID-19-kidney-PCT-S3-2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	CYP2C9 CALHM3 F2 ITIH3 ZNF488 ABCC2 SLC39A14	1.74e-06	176	144	7	b6497324e3e52f514ce556a3fa0c3011c45dcc7b
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf\|Thalamus / BrainAtlas - Mouse McCarroll V32	DCST1 UBE2D1 UBE2D4 CTLA4 SEC14L5	5.48e-06	78	144	5	5b45aacaff2a2b98c4ef8e7ac51ad482a69a1d8b
ToppCell	Thalamus-Macroglia-POLYDENDROCYTE-P1-P1_1-Trf-Oligodendrocyte.Trf.Ctps_(Ctps)\|Thalamus / BrainAtlas - Mouse McCarroll V32	DCST1 UBE2D1 UBE2D4 CTLA4 SEC14L5	5.48e-06	78	144	5	afed2f358c8a33889931bc5ad8cb24f92323e6f8
ToppCell	Club_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	ADAMTS13 NCDN HHIPL2 LRRC26 LINGO4 SDK1	9.12e-06	149	144	6	81c813588bb5efb7b31141a75d387210dcb76094
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma-3\|TCGA-Endometrium / Sample_Type by Project: Shred V9	CYP2C9 L1CAM NYX GH2 RAPGEF3 ASL	1.23e-05	157	144	6	ef70abc999be3a2c1eed7d21aef4b484f69d8567
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 GPR15 LAG3 MEI1 ARFGEF3 CTLA4	1.80e-05	168	144	6	04a7810f95196a21325356b42084f96c11af5964
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-CD45____plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAG3 SRM TG CREG2 CTLA4 PCK2	2.13e-05	173	144	6	60e427f6c7d953cef5f692043670ff0b49cdce72
ToppCell	droplet-Kidney-nan-18m-Lymphocytic-plasma_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAG3 SRM TG CREG2 CTLA4 PCK2	2.20e-05	174	144	6	c92eec5a14ca5269673582dd115ead8516e64c3e
ToppCell	droplet-Lung-nan-21m-Lymphocytic-Plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAG3 TG CHPF2 CREG2 CTLA4 PCK2	2.20e-05	174	144	6	3f4277763e312b46ebd4401ea4a2f5d4c850c768
ToppCell	droplet-Lung-nan-21m-Lymphocytic-plasma_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LAG3 TG CHPF2 CREG2 CTLA4 PCK2	2.20e-05	174	144	6	fad66d1a8407574b6a835e0bdb824a53afa58650
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	RNF130 L1CAM NLGN3 OR6B3 MTNR1A SEC14L5	3.20e-05	186	144	6	6f88b68735d0f7c9904eb8413e6007910d556185
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM3 LAG3 ASAP1 PPT1 SLC9A7 CTLA4	3.40e-05	188	144	6	c39083b8020ae507246959abbb299d78bcd14042
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM3 LAG3 ASAP1 PPT1 SLC9A7 CTLA4	3.40e-05	188	144	6	6e7a678474715f035cc13a0e226a937688f54121
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Dendritic-conventional_dendritic_cell-DC1_(conventional_dendritic_cell)-DC1_L.1.2.1.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CEACAM3 LAG3 ASAP1 PPT1 SLC9A7 CTLA4	3.40e-05	188	144	6	8862ecb87fc9b95eccc527387f2332dcc92cfdc3
Disease	isolated growth hormone deficiency (implicated_via_orthology)	TG GH1 GH2	3.46e-06	7	138	3	DOID:0060870 (implicated_via_orthology)
Disease	X-21258 measurement	CYP2C19 CYP2C9	6.49e-05	3	138	2	EFO_0800802
Disease	Hashimoto Disease	TG CTLA4	6.49e-05	3	138	2	C0677607
Disease	type 2 diabetes mellitus (biomarker_via_orthology)	CYP2C19 CPT1A GH1 GH2 MTNR1A ABCC2	6.91e-05	147	138	6	DOID:9352 (biomarker_via_orthology)
Disease	systemic scleroderma (is_marker_for)	ADAMTS13 F2 KDR IL27RA	1.12e-04	53	138	4	DOID:418 (is_marker_for)
Disease	Juvenile neuronal ceroid lipofuscinosis	PPT1 TPP1	1.29e-04	4	138	2	cv:CN293564
Disease	isolated growth hormone deficiency type II (implicated_via_orthology)	GH1 GH2	2.15e-04	5	138	2	DOID:0060872 (implicated_via_orthology)
Disease	Infantile neuronal ceroid lipofuscinosis	PPT1 TPP1	2.15e-04	5	138	2	C0268281
Disease	Non-alcoholic Fatty Liver Disease	VLDLR CPT1A F2 ABCC2	3.31e-04	70	138	4	C0400966
Disease	Nonalcoholic Steatohepatitis	VLDLR CPT1A F2 ABCC2	3.31e-04	70	138	4	C3241937
Disease	wellbeing measurement, smoking behaviour measurement	GRM1 PAFAH2	4.49e-04	7	138	2	EFO_0005671, EFO_0007869
Disease	Disorder of eye	NPHP1 NYX PPT1 TPP1 RPE65 SNRNP200	5.01e-04	212	138	6	C0015397
Disease	liver cirrhosis (is_marker_for)	ADAMTS13 F2 KDR CPEB1	6.04e-04	82	138	4	DOID:5082 (is_marker_for)
Disease	Neuronal ceroid lipofuscinosis	PPT1 TPP1	7.65e-04	9	138	2	cv:C0027877
Disease	retinitis pigmentosa (is_implicated_in)	IFT140 RPE65 SNRNP200	9.37e-04	41	138	3	DOID:10584 (is_implicated_in)
Disease	celiac disease (is_implicated_in)	F2 CTLA4	9.53e-04	10	138	2	DOID:10608 (is_implicated_in)
Disease	disseminated intravascular coagulation (is_marker_for)	ADAMTS13 F2	9.53e-04	10	138	2	DOID:11247 (is_marker_for)
Disease	X-11308 measurement	CYP2C19 CYP2C9	1.16e-03	11	138	2	EFO_0800693
Disease	myocardial infarction (is_implicated_in)	F2 GH1 KDR CTLA4	1.22e-03	99	138	4	DOID:5844 (is_implicated_in)
Disease	autoimmune thyroiditis (is_implicated_in)	TG CTLA4	1.39e-03	12	138	2	DOID:7188 (is_implicated_in)
Disease	thymol sulfate measurement	CYP2C19 CYP2C9	1.39e-03	12	138	2	EFO_0021170
Disease	arachidonoylcarnitine (C20:4) measurement	SLC16A9 CPT1A	1.39e-03	12	138	2	EFO_0800544
Disease	Unipolar Depression	CYP2C19 CYP2C9 GRM1 TG KDR CTLA4	1.41e-03	259	138	6	C0041696
Disease	Thrombosis	CYP2C19 ADAMTS13 F2	1.58e-03	49	138	3	C0040053
Disease	dihomo-linolenoylcarnitine (C20:3n3 or 6) measurement	SLC16A9 CPT1A	1.64e-03	13	138	2	EFO_0800547
Disease	autoimmune hepatitis (is_implicated_in)	F2 CTLA4	1.64e-03	13	138	2	DOID:2048 (is_implicated_in)
Disease	Colorectal Carcinoma	SETD4 GRM1 NCDN CNPPD1 FANCG KDR KDM2A ABCC2 SNRNP200 PIGO	1.76e-03	702	138	10	C0009402
Disease	congenital hypothyroidism (biomarker_via_orthology)	GH1 GH2	1.90e-03	14	138	2	DOID:0050328 (biomarker_via_orthology)
Disease	3-hydroxyanthranilic acid measurement	TG CREG2	2.19e-03	15	138	2	EFO_0010447
Disease	Hemorrhage	CYP2C9 F2	3.90e-03	20	138	2	C0019080
Disease	end stage renal disease (implicated_via_orthology)	F2 ABCC2	3.90e-03	20	138	2	DOID:783 (implicated_via_orthology)
Disease	Deep Vein Thrombosis	F2 KDR	4.30e-03	21	138	2	C0149871
Disease	Venous Thrombosis	F2 KDR	4.30e-03	21	138	2	C0042487

Protein segments in the cluster

Peptide	Gene	Start	Entry
DPRWLCTNVLGKLLS	DAPK1	1036	P53355
CILIWTLDPTSLSTR	AAAS	216	Q9NRG9
SLLLLWGLATPCQEL	BPIFB3	6	P59826
ELPGSALRSLWSSLC	ADPGK	26	Q9BRR6
RSLLCLNSWSSSLPL	LINC01551	146	Q86U37
SLATCQLSEPLLWFI	BIRC6	3071	Q9NR09
ARWSLTLLPRLECSG	LINC00269	71	Q8N2A0
RAGASLWSSCVVLPL	ADGRB1	1131	O14514
ECIPWQGLLLTASLL	CEACAM21	11	Q3KPI0
LRCLSQAIGWSVTLL	CALHM3	176	Q86XJ0
SIWFISCLLGLPTLL	GPR15	156	P49685
LLLEAFSWNLCLPTP	CCNJL	181	Q8IV13
LCNTLARGLIISWIP	CFAP46	786	Q8IYW2
LLGSTIPLCSAQWER	CPT1A	296	P50416
PRWASINLGVLLCIE	ACAP3	426	Q96P50
RLWAETLLPEDCLLG	DMXL2	266	Q8TDJ6
DPRWASINLGITLCI	ACAP2	421	Q15057
RPGTRLSWLLCCSAL	CREG2	11	Q8IUH2
AWSPCSRRQLLSLLS	ADAMTS13	261	Q76LX8
RLAALALLTCSLWPA	RNF130	11	Q86XS8
LLQSTTRLLECPWLQ	ITPR3	1501	Q14573
WLGTCRLPLTETISE	KCTD19	331	Q17RG1
FILLLAALPSWDTCN	SLC16A9	476	Q7RTY1
FSWLDSPALQRCLTL	DNAJC14	366	Q6Y2X3
LLGLALAWLRQEPTT	KLHL34	196	Q8N239
SRWPQELLQLLGSVS	NCDN	661	Q9UBB6
SLWSLEPGKCVLVNL	NUDCD3	251	Q8IVD9
LASRCLPGEQILAWA	MTMR11	41	A4FU01
RSWLLPPGTLDQFIC	LCN12	151	Q6JVE5
SGPCRSQAFTLLLWV	MMS19	791	Q96T76
RQTCSTLSGLLWELI	ASL	126	P04424
QPFSRGSFLIWLLLC	LINC00312	31	Q9Y6C7
NVWLSPVGCALSTLL	HLCS	511	P50747
GLWQSALRDCQPLLS	C1orf109	26	Q9NX04
GPQECWLLTASRLQT	HMGXB3	766	Q12766
LSPLCVLLWRELTGI	RCE1	81	Q9Y256
LSPLGWPSCRSIQTL	PCK2	16	Q16822
GSSEPCWLIRLCISI	HEATR6	646	Q6AI08
WEPLTNLSLVCLDSA	IL27RA	306	Q6UWB1
LECQSNTSLLLRWQP	L1CAM	926	P32004
PQSLRSWITCFLGII	ABCC2	1096	Q92887
PGSLRASDWVILNCS	LAG3	176	P18627
LWDSVLRASCLLPEL	FANCG	121	O15287
LLCGPLRLSESGETW	FGD3	606	Q5JSP0
RPGTVCLLSGLDWSQ	PRSS37	126	A4D1T9
VSPRLCRTLASASWL	OR2I1P	136	Q8NGU4
SLQWGITSPLLRCDE	GREB1L	871	Q9C091
ASFPCTVLLTLLLWA	GPR75	156	O95800
SGSRDCNILAWVPSL	ERCC8	351	Q13216
AERLGCTLPQLAIAW	KCNAB2	296	Q13303
ADSPRTALLCSAWLL	MEI1	1001	Q5TIA1
PLLELACSDTLLNQW	OR12D3	181	Q9UGF7
TVWAASLLLSALPLC	GPR149	156	Q86SP6
AVALLPWTCASRALQ	PPT1	11	P50897
LIECWTLEERPLLGS	KCTD18	231	Q6PI47
PTVGRSLCLTLWFLS	NLGN3	16	Q9NZ94
LLEQPTWQLALGSLC	CNPPD1	211	Q9BV87
LLRSALTTILDCWDP	HEATR5A	1801	Q86XA9
STSSCPLLRTLDLRW	KDM2A	996	Q9Y2K7
LSCLLLLSIWRQSSG	CYP2C19	11	P33261
LLLTQSLWCRVRVPS	DBF4B	546	Q8NFT6
LLEELDLGWCPTLQS	FBXL4	506	Q9UKA2
TVQRLLTWGLPVSCS	DCST1	21	Q5T197
TQPLLGEQSLLTRWS	DAGLB	556	Q8NCG7
VGCWKNLIDTLSTPL	ARFGEF3	866	Q5TH69
EPTWLSTNLGILTCI	ASAP1	461	Q9ULH1
ECIPWQGLLLTASLL	CEACAM3	11	P40198
AALQAWALLLTICPS	IFRD2	301	Q12894
LAGVTALSCWLPLRA	LYPLA1	136	O75608
GCRLFLSTIPVLWTL	EFNA2	196	O43921
AQLNLATRTWPCTLL	CTLA4	11	P16410
CLGLQSLSLTGWDRP	CPEB1	96	Q9BZB8
IALDSLSWLLLRLPC	ELP5	121	Q8TE02
LSWLLLRLPCTTLCQ	ELP5	126	Q8TE02
LSCLLLLSLWRQSSG	CYP2C9	11	P11712
WSLLLLSSALLREGC	COLGALT2	11	Q8IYK4
RAPWLSSGILCLCLI	HHIPL2	16	Q6UWX4
LPNITLGSEIRDSCW	GRM1	96	Q13255
WTPISVLNTTILCLG	GPR22	326	Q99680
QLGRPISSWTCLLDL	SEC14L5	371	O43304
RLVLTCLAEGSWPLE	SDK1	121	Q7Z5N4
QSCLLLTLLGLWRTT	SLC39A14	11	Q15043
ITVLRWSPSGNCLLS	IFT140	106	Q96RY7
SRPSRISLILTLWSC	NPHP1	376	O15259
SGNPLTCDCRLLWLL	LINGO4	356	Q6UY18
ITLAVLRIPSATGCW	OR6B2	221	Q6IFH4
LFNLAVGSCRLPVSW	PAFAH2	76	Q99487
TPGLLQSPRSWFLLC	OSBPL5	851	Q9H0X9
RQPWFLLASCLLPSV	NYX	456	Q9GZU5
TGRIPLWLTGSLLRC	RPE65	31	Q16518
LLSCSADGTVRLWNP	STRN3	601	Q13033
AWASLLSQLLRPPCA	HARS2	11	P49590
PGSLWILKLSCTVLA	SFXN4	281	Q6P4A7
WPCLILALLSSLAAS	ITIH3	6	Q06033
CSWLVPLVRTLLDRA	NBEAL2	1661	Q6ZNJ1
CPLLSNLATRLWLRN	SEMA4B	611	Q9NPR2
GPSWRLLTALKLLCL	SETD4	336	Q9NVD3
PQLDRGTLCQWSTLS	THNSL2	36	Q86YJ6
LVWSLCSVLQADPSR	WDR18	146	Q9BV38
TICLWLRSSASPGIG	NPTX2	251	P47972
ITLAVLRIPSATGCW	OR6B3	221	Q8NGW1
NTSLTCGPALVPRLW	MRPS12	11	O15235
SWLTARCFLPRLDTG	AURKAIP1	76	Q9NWT8
SLGCSLSLLRVSWIQ	CHPF2	21	Q9P2E5
LCLSWLQEGSAFPTI	GH2	16	P01242
RWIQSLALLLPNCSS	SWI5	86	Q1ZZU3
NGSICLDILRSQWSP	UBE2D2	81	P62837
SCIQGLRWTPLTNSE	RAPGEF3	66	O95398
LNTTDLACWGRLSTP	ZNF488	196	Q96MN9
PSGARWTCLQLDLQD	WDR90	136	Q96KV7
ASGLRPCLWQLETEL	RLF	46	Q13129
QRWATALTCLLRGLP	SPHK2	151	Q9NRA0
LTLRWLLGDPTCCVL	SLC27A5	31	Q9Y2P5
TLVLGSSVWLPCRVT	ROBO3	461	Q96MS0
QLPWLNUSSCLSLLR	SELENON	121	Q9NZV5
RWLLLCNPGLADTIV	PYGB	491	P11216
NGSICLDILRSQWSP	UBE2D3	81	P61077
LLLLSSWCRTGLADP	RAET1G	16	Q6H3X3
RTSLLLAFGLLCLPW	GH1	6	P01241
RVLVPWDSQTLLACG	SEMA6C	126	Q9H3T2
LCLDLGAVLSPAWVT	TMEM47	31	Q9BQJ4
FRETCSLWPGQALSL	SRM	21	P19623
LSLLRVLWCLLPQTG	PIGZ	41	Q86VD9
LLCWDPRLSQAGTDS	UNC5B	16	Q8IZJ1
LWELLCPLLRTALSN	PSME4	1401	Q14997
CRLSWGLVLESLQQP	SNX19	931	Q92543
TLDGLLCTSLPVWLE	GART	316	P22102
CVDVLSSNGWLSPAL	SNRNP200	1926	O75643
PQELLCGASLISDRW	F2	386	P00734
SLLQGLSACPAFIRW	USP30	81	Q70CQ3
LLLLWPFLCESQGLR	PIGO	956	Q8TEQ8
LWLCVETRAASVGLP	KDR	11	P35968
RLDQLLGPSCSRWET	PIEZO1	86	Q92508
LCTGSRDNTLLLWDV	WDR31	161	Q8NA23
NGSICLDILRSQWSP	UBE2D4	81	Q9Y2X8
TTTLPAWCGLLARCL	SLC9A7	621	Q96T83
LDGLCLPALWSRLET	GTF3C1	16	Q12789
GWALVSDILLCLPLS	GTF3C1	901	Q12789
TPVFWLLEGRTLTLC	TRIM65	486	Q6PJ69
PLICSLESGRWESQL	TG	1261	P01266
EFRPLSCLLVLLGWT	ZFYVE26	361	Q68DK2
ALSGPCQLWSLTLSV	PSPN	61	O60542
CQLWSLTLSVAELGL	PSPN	66	O60542
NGSICLDILRSQWSP	UBE2D1	81	P51668
TCWLSIRQAELLLPG	TPP1	121	O14773
LLLALCWAPRESGAT	VLDLR	11	P98155
PGLLSSSWARRLLCL	KIAA2013	11	Q8IYS2
ARPSWLASALACVLI	MTNR1A	21	P48039
AETVLCVWPGRLTLS	LRRC26	226	Q2I0M4