Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aryl hydrocarbon receptor binding	NCOA2 AHR	1.85e-04	9	46	2	GO:0017162
GeneOntologyMolecularFunction	G-rich strand telomeric DNA binding	HNRNPA1L2 HNRNPA2B1	2.82e-04	11	46	2	GO:0098505
GeneOntologyMolecularFunction	single-stranded telomeric DNA binding	HNRNPA1L2 HNRNPA2B1	3.98e-04	13	46	2	GO:0043047
GeneOntologyMolecularFunction	sequence-specific single stranded DNA binding	HNRNPA1L2 HNRNPA2B1	5.35e-04	15	46	2	GO:0098847
GeneOntologyCellularComponent	catalytic step 2 spliceosome	HNRNPA1L2 HNRNPA1L3 HNRNPA2B1 PPIL3	5.61e-05	97	45	4	GO:0071013
Domain	HnRNPA1	HNRNPA1L2 HNRNPA2B1	1.62e-05	3	44	2	PF11627
Domain	HnRNPA1	HNRNPA1L2 HNRNPA2B1	1.62e-05	3	44	2	IPR021662
Domain	PAS	NCOA2 AHR	1.57e-03	25	44	2	PF00989
Domain	PAS_fold	NCOA2 AHR	1.57e-03	25	44	2	IPR013767
Domain	PAC	NCOA2 AHR	1.70e-03	26	44	2	SM00086
Domain	PAC	NCOA2 AHR	1.70e-03	26	44	2	IPR001610
Domain	Cadherin_CS	PCDHB2 CDH9 FAT3	2.15e-03	109	44	3	IPR020894
Domain	Cadherin	PCDHB2 CDH9 FAT3	2.38e-03	113	44	3	PF00028
Domain	CADHERIN_1	PCDHB2 CDH9 FAT3	2.38e-03	113	44	3	PS00232
Domain	CADHERIN_2	PCDHB2 CDH9 FAT3	2.44e-03	114	44	3	PS50268
Domain	-	PCDHB2 CDH9 FAT3	2.44e-03	114	44	3	2.60.40.60
Domain	CA	PCDHB2 CDH9 FAT3	2.51e-03	115	44	3	SM00112
Domain	Cadherin-like	PCDHB2 CDH9 FAT3	2.57e-03	116	44	3	IPR015919
Domain	PAS	NCOA2 AHR	2.57e-03	32	44	2	SM00091
Domain	Cadherin	PCDHB2 CDH9 FAT3	2.70e-03	118	44	3	IPR002126
Domain	PAS	NCOA2 AHR	2.90e-03	34	44	2	IPR000014
Domain	PAS	NCOA2 AHR	2.90e-03	34	44	2	PS50112
Domain	SH3_1	SH3GLB1 FGR SH3BP4	6.76e-03	164	44	3	PF00018
Domain	Zinc_finger_PHD-type_CS	KMT2E PYGO1	1.03e-02	65	44	2	IPR019786
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	HELZ PDE3B ARID1A MYO6 HNRNPA2B1 SEC24B	1.28e-06	263	46	6	34702444
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	NCOA2 ANKRD44 PDE3B MME ARID1A MYO6 BCAS3 HNRNPA2B1 PLBD2 LRRC27 SH3BP4	2.86e-06	1489	46	11	28611215
Pubmed	A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1.	HNRNPA1L2 HNRNPA2B1	5.13e-06	3	46	2	27151978
Pubmed	Activation function 2 mediates dioxin-induced recruitment of estrogen receptor alpha to CYP1A1 and CYP1B1.	NCOA2 AHR	5.13e-06	3	46	2	19460354
Pubmed	Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.	HNRNPA1L2 MYO6 HNRNPA2B1	8.57e-06	30	46	3	28077597
Pubmed	Quantitative analysis of PPT1 interactome in human neuroblastoma cells.	HNRNPA1L2 TFG HNRNPA2B1 PLBD2 SCG2	8.58e-06	210	46	5	26217791
Pubmed	Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription.	NCOA2 AHR	1.03e-05	4	46	2	15383530
Pubmed	Fate-mapping analysis using Rorb-IRES-Cre reveals apical-to-basal gradient of Rorb expression in mouse cochlea.	RORB MYO6	1.03e-05	4	46	2	31487081
Pubmed	Decrease in hnRNP A/B expression during erythropoiesis mediates a pre-mRNA splicing switch.	HNRNPA1L2 HNRNPA2B1	1.03e-05	4	46	2	12426391
Pubmed	Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex.	NCOA2 AHR	1.03e-05	4	46	2	12024042
Pubmed	NcoA2-Dependent Inhibition of HIF-1α Activation Is Regulated via AhR.	NCOA2 AHR	1.03e-05	4	46	2	26350169
Pubmed	Calmodulin-dependent kinase IV stimulates vitamin D receptor-mediated transcription.	NCOA2 FGR	1.71e-05	5	46	2	15919723
Pubmed	The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.	HNRNPA1L2 HNRNPA2B1	1.71e-05	5	46	2	20133837
Pubmed	HNRNPA1-induced spliceopathy in a transgenic mouse model of myotonic dystrophy.	HNRNPA1L2 HNRNPA2B1	3.58e-05	7	46	2	32086392
Pubmed	Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions.	NCOA2 AHR	3.58e-05	7	46	2	15641800
Pubmed	WASH maintains NKp46+ ILC3 cells by promoting AHR expression.	AHR ARID1A	3.58e-05	7	46	2	28589939
Pubmed	Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor.	ARID1A TFG SEC24B	4.06e-05	50	46	3	27716508
Pubmed	The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.	NCOA2 ARID1A	7.65e-05	10	46	2	17363140
Pubmed	A neurogenomics approach to gene expression analysis in the developing brain.	PSMD8 PDE3B HNRNPA1L2 SCG2	7.66e-05	170	46	4	15582152
Pubmed	The biogenesis of the coiled body during early mouse development.	HNRNPA1L2 HNRNPA2B1	1.12e-04	12	46	2	7768196
Pubmed	Hepatocyte Growth Factor-c-MET Signaling Mediates the Development of Nonsensory Structures of the Mammalian Cochlea and Hearing.	MYO6 DCT	1.32e-04	13	46	2	27488639
Pubmed	SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.	PSMD8 ARID1A PLBD2 SEC24B SH3BP4	1.40e-04	378	46	5	34315543
Pubmed	Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.	PCDHB18P PCDHB2 CDH9	1.48e-04	77	46	3	10835267
Pubmed	An oocyte-specific ELAVL2 isoform is a translational repressor ablated from meiotically competent antral oocytes.	HNRNPA1L2 HNRNPA2B1	1.54e-04	14	46	2	24553115
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	ANKRD44 CPNE1 AASDHPPT PSMD8 ARID1A HNRNPA2B1	2.43e-04	670	46	6	22990118
Pubmed	The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.	RORB DCT FAT3	2.67e-04	94	46	3	23431145
Pubmed	Germline Chd8 haploinsufficiency alters brain development in mouse.	HNRNPA1L2 HNRNPA2B1	3.20e-04	20	46	2	28671691
Pubmed	The human and murine protocadherin-beta one-exon gene families show high evolutionary conservation, despite the difference in gene number.	PCDHB18P PCDHB2	3.20e-04	20	46	2	11322959
Pubmed	Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.	NCOA2 HELZ ARID1A TFG RAVER2	3.37e-04	457	46	5	32344865
Pubmed	Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.	HNRNPA1L2 HNRNPA2B1	3.89e-04	22	46	2	12456657
Pubmed	Human transcription factor protein interaction networks.	NCOA2 HELZ PSMD8 ARID1A MYO6 PPIL3 SEC24B PYGO1	5.16e-04	1429	46	8	35140242
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	PCDHB2 MYO6 TFG HNRNPA2B1 SEC24B SH3BP4	5.34e-04	777	46	6	35844135
Pubmed	SOX9 and SOX10 control fluid homeostasis in the inner ear for hearing through independent and cooperative mechanisms.	MME DCT	5.88e-04	27	46	2	36343245
Pubmed	Abnormal neocortex arealization and Sotos-like syndrome-associated behavior in Setd2 mutant mice.	PCDHB2 RORB	6.33e-04	28	46	2	33523829
Pubmed	TERRA transcripts are bound by a complex array of RNA-binding proteins.	HNRNPA1L2 HNRNPA2B1	6.33e-04	28	46	2	20975687
Pubmed	Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.	ARID1A TFG	6.33e-04	28	46	2	30037996
Pubmed	Fgf10 is required for specification of non-sensory regions of the cochlear epithelium.	MYO6 DCT	6.79e-04	29	46	2	25624266
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	MYO6 SEC24B	7.77e-04	31	46	2	22323290
Pubmed	Large-scale analysis of the human ubiquitin-related proteome.	USP4 PSMD8 MYO6 HNRNPA2B1	7.80e-04	313	46	4	16196087
Pubmed	Proline-rich sequence recognition: II. Proteomics analysis of Tsg101 ubiquitin-E2-like variant (UEV) interactions.	TFG SEC24B	8.28e-04	32	46	2	19542561
Pubmed	Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.	MYO6 HNRNPA2B1	8.28e-04	32	46	2	21951318
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	AASDHPPT PSMD8 HNRNPA1L2 ARID1A MYO6 HNRNPA2B1	8.37e-04	847	46	6	35235311
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	HELZ MYO6 BCAS3 SEC24B	8.66e-04	322	46	4	39098523
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	HELZ PDE3B BCAS3 WDR59 SEC24B SH3BP4	9.11e-04	861	46	6	36931259
Pubmed	HIV gp120 induced gene expression signatures in vaginal epithelial cells.	MME FGR	9.90e-04	35	46	2	23867815
Cytoband	7p15	AHR HNRNPA2B1	8.87e-05	14	46	2	7p15
Cytoband	2q33.1	ANKRD44 PPIL3	1.21e-03	51	46	2	2q33.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8q13	NCOA2 MCMDC2	2.67e-03	76	46	2	chr8q13
Cytoband	Ensembl 112 genes in cytogenetic band chr7p15	HOXA3 HNRNPA2B1	4.66e-03	101	46	2	chr7p15
Coexpression	TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_6HR_UP	HOXA3 PCDHB2 TEX15 CDH9	1.52e-05	87	45	4	M18559
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-5517_k-means-cluster#4_top-relative-expression-ranked_1000	HOXA3 NCOA2 MME BCAS3 FAT3 SEC24B SLITRK4	1.53e-05	385	45	7	gudmap_developingLowerUrinaryTract_e14.5_ urogenital sinus_1000_k4
ToppCell	(6)_ILC\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	HOXA3 AHR FAT3 SH3BP4 SORCS1	1.44e-06	188	46	5	de7cb273899d0e0748c85f45c6b5e7f0642ab057
ToppCell	(6)_ILC\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	HOXA3 AHR FAT3 SH3BP4 SORCS1	1.44e-06	188	46	5	f4734d5b703678670ece204a0519cf015e180a6e
ToppCell	10x5'-lymph-node_spleen-Hematopoietic_progenitors-Progenitor\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXA3 RORB MME FAT3	2.52e-05	165	46	4	7b992843bd8ef92a7a76b1d681fa84efde6f5bdd
ToppCell	Posterior_cortex-Neuronal-Inhibitory\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	MME CDH9 SCG2 PYGO1	2.65e-05	167	46	4	9a84f45345c75f2c8ff38a04245aadee2a26a240
ToppCell	wk_08-11-Epithelial-PNS-FGFBP2+_Neural_progenitor\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	RORB CDH9 SCG2 SORCS1	3.32e-05	177	46	4	15a5c96ea840376e54933ebe7a8334a11d9ce411
ToppCell	wk_15-18-Epithelial-PNS-Early_Schwann\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	RORB HNRNPA1L3 TMEM249 SORCS1	3.78e-05	183	46	4	7e8366ec8117d36cec67f77dcb0e9a6032d87fcb
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	HNRNPA1L3 SCG2 SLITRK4 SORCS1	4.03e-05	186	46	4	531774f2ba8bef5ed355edc86c670bb97ae85900
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	HOXA3 AHR SH3BP4 SORCS1	4.56e-05	192	46	4	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHR ANKRD44 MME CDH9	4.65e-05	193	46	4	c7e9e6e4bf5e07c9cbdf1aa7c8828f4b2500e3ff
ToppCell	Control-Stromal-Myofibroblast\|Stromal / Disease state, Lineage and Cell class	PDE3B MME BCAS3 FAT3	4.65e-05	193	46	4	5896242f713ae5fd1a4ebb63827f15d7279dced2
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	AHR ANKRD44 CDH9 PYGO1	4.75e-05	194	46	4	1bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCell	Control_saline-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	AHR PDE3B SH3GLB1 MYO6	5.34e-05	200	46	4	3372c488a39fe812fa94e4f0564594186fea3db5
ToppCell	Control_saline-Endothelial-Endothelial-Alv_Gen_Intermediate\|Control_saline / Treatment groups by lineage, cell group, cell type	AHR PDE3B SH3GLB1 MYO6	5.34e-05	200	46	4	041a34080120c9f613373c20dcc366292f558040
ToppCell	Control_saline-Endothelial-Endothelial\|Control_saline / Treatment groups by lineage, cell group, cell type	AHR PDE3B SH3GLB1 MYO6	5.34e-05	200	46	4	e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANKRD44 HELZ KMT2E HNRNPA2B1	5.34e-05	200	46	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	myopathy (implicated_via_orthology)	HNRNPA1L2 HNRNPA1L3 HNRNPA2B1	5.11e-05	48	44	3	DOID:423 (implicated_via_orthology)
Disease	optic cup area measurement	HNRNPA1L3 BCAS3 FAT3	8.11e-05	56	44	3	EFO_0006940
Disease	Lung Injury	AHR MME	4.48e-04	21	44	2	C0273115
Disease	Chronic Lung Injury	AHR MME	4.48e-04	21	44	2	C2350344
Disease	putamen volume	HELZ FAT3	9.83e-04	31	44	2	EFO_0006932
Disease	heart conduction disease (implicated_via_orthology)	MME PYGO1	1.05e-03	32	44	2	DOID:10273 (implicated_via_orthology)
Disease	pelvic organ prolapse	DCT HNRNPA1L3 CDH9	1.10e-03	136	44	3	EFO_0004710
Disease	neurodegenerative disease (implicated_via_orthology)	HNRNPA1L2 HNRNPA1L3 HNRNPA2B1	1.33e-03	145	44	3	DOID:1289 (implicated_via_orthology)
Disease	neuroticism measurement, cognitive function measurement	CPNE1 USP4 ARID1A MYO6 CDH9	1.49e-03	566	44	5	EFO_0007660, EFO_0008354
Disease	prostate cancer (is_marker_for)	NCOA2 KMT2E MYO6	1.64e-03	156	44	3	DOID:10283 (is_marker_for)
Disease	Congenital Heart Defects	HOXA3 AHR	1.98e-03	44	44	2	C0018798
Disease	thyroid peroxidase antibody measurement, anti-thyroglobulin antibody measurement	RORB WDR59	2.07e-03	45	44	2	EFO_0005666, EFO_0009896
Disease	Hypermetropia, Myopia	NCOA2 RORB PYGO1	2.82e-03	189	44	3	HP_0000540, HP_0000545

Protein segments in the cluster

Peptide	Gene	Start	Entry
PFNCPQQDPQQYNVF	AHR	661	P35869
KDSSNPYPNFNFNIS	AASDHPPT	96	Q9NRN7
QDSYNNFTNNNPGNP	BCAS3	501	Q9H6U6
NDFGNYNNQSSNFGP	HNRNPA1L2	261	Q32P51
NDFGNYNNQSSNFGP	HNRNPA1L3	216	A0A2R8Y4L2
NFSGSQPYLQSFPNL	RAVER2	521	Q9HCJ3
QDYQQSNQPGPFQFS	NOBOX	506	O60393
ANDNSPFVLYPLQNG	PCDHB2	556	Q9Y5E7
ANDNSPFVLYPLQNG	PCDHB18P	501	Q96TA0
RQPNYNALPNANYPS	ARID1A	811	O14497
AFQGYSNNQPFRFQS	MCMDC2	216	Q4G0Z9
PNYSNFSSQAINPGF	FGR	51	P09769
ANGFAYNANQQPYPA	HOXA3	21	O43365
YNANQQPYPASAALG	HOXA3	26	O43365
GNAPNTPDFYQQLRN	PDE3B	556	Q13370
SIFQGFLNLYFQNNP	GSTO2	221	Q9H4Y5
QPPFFSAQQSNSLNY	MME	561	P08473
QRNFYPAAQNLPANT	KMT2E	1496	Q8IZD2
YSQFNQQSLNSTAPP	KMT2E	1531	Q8IZD2
YGANVNQPNNNGFTP	ANKRD44	261	Q8N8A2
PAYQAGPNNAFFNSA	HELZ	1421	P42694
YVQHGAPANPQNFNI	IFT172	1466	Q9UG01
VNGSFPQCNNAPKYQ	FBXO45	211	P0C2W1
LDNNDNGPEFSQPNY	FAT3	1451	Q8TDW7
FQQYPQQYPGVNQLS	SEC24B	491	O95487
VNNNPPRFPQSTYQF	CDH9	261	Q9ULB4
ALNFNPSNPYCAGIQ	CPNE1	356	Q99829
FGNPSYNNALSQNVN	PYGO1	156	Q9Y3Y4
PPWSNFYHLNFQNNF	SLITRK4	56	Q8IW52
YSNNPFWNGVQTNPF	SH3BP4	156	Q9P0V3
LPAAQPQNTFFNTKY	LRRC27	506	Q9C0I9
FFGPNSPASLYQQNQ	RGS22	916	Q8NE09
ANQKTSYFPNPYNQE	SCG2	446	P13521
QLGSFPSNYLSNNNQ	SH3GLB1	251	Q9Y371
AQQFPFPPNYGISQQ	NCOA2	1296	Q15596
RFAPQFSGYQQQDSQ	USP4	381	Q13107
NDFGNYNQQPSNYGP	HNRNPA2B1	301	P22626
QQFQGYGQQPTSQAP	TFG	286	Q92734
NNGPNTNGSQFFITY	PPIL3	91	Q9H2H8
PNLFTYSSFNNGQLA	RORB	201	Q92753
GASVDNYQQPPFTQN	nan	196	A8MWL6
NPPFFQNSTFSFRNA	DCT	336	P40126
QYPNNAAPSFQFINP	WDR59	436	Q6PJI9
LNPANGSYPFQALRQ	PLBD2	511	Q8NHP8
GPNNYYSFASQQQKP	PSMD8	311	P48556
GYFQSQIPASNFRQP	TEX15	2731	Q9BXT5
QNCTEANRNQPFPGY	SORCS1	351	Q8WY21
LKNNSFYPFVQQEPN	TMEM249	36	Q2WGJ8
YDFAPFLNNSPQQNP	MYO6	1146	Q9UM54