Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	zf-B_box	TRIM63 RNF207 TRIM26	5.27e-04	72	41	3	PF00643
Domain	ZF_BBOX	TRIM63 RNF207 TRIM26	7.17e-04	80	41	3	PS50119
Domain	Znf_B-box	TRIM63 RNF207 TRIM26	7.44e-04	81	41	3	IPR000315
Domain	zf-C3HC4	TRIM63 RNF207 TRIM26 NFX1	1.42e-03	223	41	4	PF00097
Domain	Kazal_2	FSTL3 SLCO1A2	2.83e-03	36	41	2	PF07648
Domain	ZF_RING_1	TRIM63 RNF207 TRIM26 NFX1	3.71e-03	291	41	4	PS00518
Domain	ZF_RING_2	TRIM63 RNF207 TRIM26 NFX1	4.04e-03	298	41	4	PS50089
Domain	RING	TRIM63 RNF207 TRIM26 NFX1	4.39e-03	305	41	4	SM00184
Domain	KAZAL	FSTL3 SLCO1A2	4.58e-03	46	41	2	SM00280
Domain	KAZAL_2	FSTL3 SLCO1A2	5.39e-03	50	41	2	PS51465
Domain	Znf_RING	TRIM63 RNF207 TRIM26 NFX1	5.55e-03	326	41	4	IPR001841
Domain	Kazal_dom	FSTL3 SLCO1A2	5.60e-03	51	41	2	IPR002350
Domain	Znf_C3HC4_RING-type	TRIM63 RNF207 TRIM26	6.33e-03	172	41	3	IPR018957
Domain	BBOX	TRIM63 TRIM26	1.01e-02	69	41	2	SM00336
Domain	-	TRIM63 TRIM26	1.06e-02	71	41	2	4.10.45.10
Domain	F-box_dom	TMEM183BP FBXO22	1.18e-02	75	41	2	IPR001810
Pubmed	MEK1/2 inhibitors activate macrophage ABCG1 expression and reverse cholesterol transport-An anti-atherogenic function of ERK1/2 inhibition.	NR1H3 ABCG1	1.64e-06	2	45	2	27365310
Pubmed	Homocysteine accelerates atherosclerosis via inhibiting LXRα-mediated ABCA1/ABCG1-dependent cholesterol efflux from macrophages.	NR1H3 ABCG1	4.91e-06	3	45	2	30393020
Pubmed	Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXRα signaling pathway in THP-1 macrophage-derived foam cells.	NR1H3 ABCG1	4.91e-06	3	45	2	23564066
Pubmed	Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes.	NR1H3 ABCG1	4.91e-06	3	45	2	27251372
Pubmed	α-Lipoic acid ameliorates foam cell formation via liver X receptor α-dependent upregulation of ATP-binding cassette transporters A1 and G1.	NR1H3 ABCG1	4.91e-06	3	45	2	21034810
Pubmed	Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes.	NR1H3 ABCG1	4.91e-06	3	45	2	26603933
Pubmed	LXR signaling couples sterol metabolism to proliferation in the acquired immune response.	NR1H3 ABCG1	9.81e-06	4	45	2	18614014
Pubmed	GPS2 is required for cholesterol efflux by triggering histone demethylation, LXR recruitment, and coregulator assembly at the ABCG1 locus.	NR1H3 ABCG1	9.81e-06	4	45	2	19481530
Pubmed	Bis(monoacylglycero)phosphate accumulation in macrophages induces intracellular cholesterol redistribution, attenuates liver-X receptor/ATP-Binding cassette transporter A1/ATP-binding cassette transporter G1 pathway, and impairs cholesterol efflux.	NR1H3 ABCG1	9.81e-06	4	45	2	23788762
Pubmed	Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein.	NR1H3 ABCG1	9.81e-06	4	45	2	15319426
Pubmed	The critical role of ABCG1 and PPARγ/LXRα signaling in TLR4 mediates inflammatory responses and lipid accumulation in vascular smooth muscle cells.	NR1H3 ABCG1	9.81e-06	4	45	2	27807703
Pubmed	PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway.	NR1H3 ABCG1	1.63e-05	5	45	2	22503545
Pubmed	Apoptotic cells promote their own clearance and immune tolerance through activation of the nuclear receptor LXR.	NR1H3 ABCG1	1.63e-05	5	45	2	19646905
Pubmed	Plasma concentrations of TNF-alpha and its soluble receptors sTNFR1 and sTNFR2 in patients with coronary artery disease.	TNFRSF1A ADA	1.63e-05	5	45	2	19845893
Pubmed	Liver X receptors are required for thymic resilience and T cell output.	NR1H3 ABCG1	1.63e-05	5	45	2	32716519
Pubmed	Propofol up-regulates expression of ABCA1, ABCG1, and SR-B1 through the PPARγ/LXRα signaling pathway in THP-1 macrophage-derived foam cells.	NR1H3 ABCG1	1.63e-05	5	45	2	25600616
Pubmed	Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.	M6PR VPS53	1.63e-05	5	45	2	18367545
Pubmed	TGF-beta1 up-regulates expression of ABCA1, ABCG1 and SR-BI through liver X receptor alpha signaling pathway in THP-1 macrophage-derived foam cells.	NR1H3 ABCG1	1.63e-05	5	45	2	20057170
Pubmed	Defective cholesterol clearance limits remyelination in the aged central nervous system.	NR1H3 ABCG1	2.45e-05	6	45	2	29301957
Pubmed	LXR Suppresses Inflammatory Gene Expression and Neutrophil Migration through cis-Repression and Cholesterol Efflux.	NR1H3 ABCG1	3.42e-05	7	45	2	30590048
Pubmed	Liver X receptors inhibit macrophage proliferation through downregulation of cyclins D1 and B1 and cyclin-dependent kinases 2 and 4.	NR1H3 ABCG1	7.32e-05	10	45	2	21398609
Pubmed	USP9X-mediated KDM4C deubiquitination promotes lung cancer radioresistance by epigenetically inducing TGF-β2 transcription.	PPP2R2A FBXO22	8.94e-05	11	45	2	33558705
Pubmed	Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm.	XPO5 EIF1AX	2.47e-04	18	45	2	12426392
Pubmed	Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.	TNFRSF1A PLEKHG6	6.06e-04	28	45	2	24836286
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	RSPO2 WNT8A	6.50e-04	29	45	2	22956684
Pubmed	Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.	RSPO2 WNT8A	6.96e-04	30	45	2	21936019
Pubmed	Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.	RSPO2 WNT8A	6.96e-04	30	45	2	19282366
Pubmed	Liver X receptors and oxysterols promote ventral midbrain neurogenesis in vivo and in human embryonic stem cells.	NR1H3 ABCG1	7.43e-04	31	45	2	19796621
Pubmed	Genetic variations in humans associated with differences in the course of hepatitis C.	TNFRSF1A ADA	7.92e-04	32	45	2	15063762
Pubmed	Proximity labeling reveals dynamic changes in the SQSTM1 protein network.	SASS6 KANK1 TBRG4 NFX1	7.97e-04	322	45	4	39098523
Pubmed	Hypertrophic Cardiomyopathy Overview	TRIM63 MYPN	8.94e-04	34	45	2	20301725
Pubmed	A Y2H-seq approach defines the human protein methyltransferase interactome.	RSPO2 NR1H3 VPS37A JMJD1C	9.96e-04	342	45	4	23455924
Cytoband	10q21.3	JMJD1C MYPN	5.17e-04	34	45	2	10q21.3
GeneFamily	Ring finger proteins	TRIM63 RNF207 TRIM26	7.77e-03	275	27	3	58
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM63 TRIM26	8.80e-03	95	27	2	59
Disease	Nephrotic Syndrome	KANK1 XPO5	6.79e-04	27	42	2	C0027726
Disease	progressive supranuclear palsy	DAND5 SLCO1A2	8.96e-04	31	42	2	MONDO_0019037
Disease	cortical thickness	RSPO2 PPP2R2A DAND5 ABCG1 XPO5 JMJD1C SLCO1A2	9.05e-04	1113	42	7	EFO_0004840
Disease	apolipoprotein A 1 measurement	NR1H3 DAND5 ADA M6PR VPS53 JMJD1C	1.20e-03	848	42	6	EFO_0004614
Disease	mitochondrial DNA measurement	TBRG4 POLG2 ADA JMJD1C	1.20e-03	328	42	4	EFO_0006312
Disease	interleukin 12 measurement	JMJD1C NFX1	2.60e-03	53	42	2	EFO_0004753
Disease	Hypertrophic Cardiomyopathy	TRIM63 MYPN	3.00e-03	57	42	2	C0007194

Protein segments in the cluster

Peptide	Gene	Start	Entry
ERDFGVKARSILCCM	ADA	141	P00813
VRAVREGMCDSDHKR	ABCG1	341	P45844
IRLCDMRASALCDRH	PPP2R2A	251	P63151
IGKCRAEMLEHVRRT	ARC	31	Q7LC44
VKVTCLREFIRMHCT	BEND4	456	Q6ZU67
CTCTDRRAEKLVMDG	PKD1L1-AS1	101	Q9H7B7
RKCRQAGMREECVLS	NR1H3	156	Q13133
ECRGHKRARKRTSME	FBXO22	116	Q8NEZ5
RRVKISTMLIEGCHC	DAND5	171	Q8N907
DCREHCRRGMKAKQL	HHLA3	66	Q9XRX5
KRAVRGVREMCDACE	JMJD1C	1836	Q15652
AFMTKTCECGRTRHT	NFX1	471	Q12986
ECGRRKEMVICSEAS	NFX1	891	Q12986
VKERVEMHDRCAGRS	KANK1	571	Q14678
MRSRVAVRACHKVCR	POLG2	1	Q9UHN1
HMVCTGRTHTDRICR	POMGNT2	66	Q8NAT1
EDGGCRRKCFQVMRH	MAB21L3	251	Q8N8X9
CEKHKRSGRQMLCDL	PLEKHG6	291	Q3KR16
GLCDRCMVTQELARK	RBBP8NL	71	Q8NC74
CLGDHSMRARDRARV	RGL4	281	Q8IZJ4
SLGVAMHLCCRRRRA	CD8B2	186	A6NJW9
EAHTNILRCMRDCRV	FHIP1A	506	Q05DH4
VMYRGRCRKSCEHVV	FSTL3	161	O95633
RLAHCRSTMEVVREK	CCDC183	81	Q5T5S1
AESCLDRRSEMRLKH	IP6K1	346	Q92551
CKDCEERRVSIRMSI	SASS6	16	Q6UVJ0
MAAHLVKRCTCLLRE	TBRG4	1	Q969Z0
IRCFRDMQKESRAHC	RNF207	176	Q6ZRF8
PSCLCEMKIRRRRHE	TMEM105	71	Q8N8V8
ESMEKLHCLRACVIR	TMEM183BP	191	Q1AE95
MGETEKRIETHRIRC	SLCO1A2	1	P46721
AESRRCKMTMRHCPG	RSPO2	191	Q6UXX9
MSRRRISCKDLGHAD	CNK3/IPCEF1	491	G9CGD6
GRFRCPTCRHEVIMD	TRIM63	71	Q969Q1
CSECRKTFRHRSGLM	ZSCAN30	471	Q86W11
LRKSRVEFCHEEMRT	TNIP3	181	Q96KP6
HCGKEQRRAVVMISC	M6PR	131	P20645
HKRTDRSILCCLRKG	PTGES3	66	Q15185
RRHACSSIIKMCRDY	XPO5	601	Q9HAV4
DGKLLCVMCRESREH	TRIM26	116	Q12899
CHVTRAELAKIMRTR	VPS53	321	Q5VIR6
AVRATMKRTCKCHGI	WNT8A	171	Q9H1J5
LRHCLSCSKCRKEMG	TNFRSF1A	96	P19438
FMEKRTICHCRRAKE	VPS37A	366	Q8NEZ2
RMHSGEKRFICSECG	ZNF606	756	Q8WXB4
KNRRCHMVERLCESR	ZNF14	61	P17017
HMVERLCESRRGSKC	ZNF14	66	P17017
RLEAMCFDGVKRLCH	EIF1AX	46	P47813
DMVAHEGRLCRLDCK	MYPN	1081	Q86TC9