Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF597 ZNF263 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF888 ZNF205 ZNF616 ZNF880 ZNF524 ZNF606 ZFP69 ZNF658B ZNF623 SNAI3 ZNF181 ZNF239	1.57e-24	1459	50	32	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF597 ZNF263 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF888 ZNF205 ZNF616 ZNF880 ZNF606 ZFP69 ZNF658B ZNF623 SNAI3 ZNF181 ZNF239	1.29e-23	1412	50	31	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF597 ZNF263 ZNF600 ZNF527 ZNF586 ZSCAN10 ZNF628 ZNF473 ZFP3 ZNF658 ZNF341 ZBTB25 ZFP30 ZSCAN26 ZNF202 MECOM ZNF888 ZNF205 ZNF616 ZNF880 ZNF524 ZNF606 ZNF658B ZNF623 SNAI3 ZNF181 ZNF239	5.80e-20	1244	50	27	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF597 ZNF263 ZNF600 ZNF527 ZNF586 ZSCAN10 ZNF628 ZNF473 ZFP3 ZNF658 ZNF341 ZBTB25 ZFP30 ZSCAN26 ZNF202 MECOM ZNF888 ZNF205 ZNF616 ZNF880 ZNF524 ZNF606 ZNF658B ZNF623 SNAI3 ZNF181 ZNF239	1.01e-19	1271	50	27	GO:0000987
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	SETDB2 PRDM8 MECOM	4.15e-06	13	50	3	GO:0046974
GeneOntologyMolecularFunction	DNA-binding transcription activator activity	ZNF597 ZNF600 ZNF628 ZNF473 ZNF658 ZNF341 MECOM ZNF606 ZNF658B	9.85e-06	566	50	9	GO:0001216
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF263 ZFP3 ZBTB25 ZNF202 ZNF205 SNAI3 ZNF239	1.41e-05	320	50	7	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF263 ZFP3 ZBTB25 ZNF202 ZNF205 SNAI3 ZNF239	1.59e-05	326	50	7	GO:0001217
GeneOntologyMolecularFunction	DNA-binding transcription activator activity, RNA polymerase II-specific	ZNF597 ZNF600 ZNF628 ZNF473 ZNF658 MECOM ZNF606 ZNF658B	6.92e-05	560	50	8	GO:0001228
GeneOntologyMolecularFunction	histone H3K9 monomethyltransferase activity	SETDB2 MECOM	1.70e-04	8	50	2	GO:0140948
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETDB2 PRDM8 MECOM	1.82e-04	44	50	3	GO:0140938
GeneOntologyMolecularFunction	histone modifying activity	SETDB2 PRDM8 MECOM JADE1 HUWE1	2.64e-04	229	50	5	GO:0140993
GeneOntologyMolecularFunction	histone H3K9me2 methyltransferase activity	SETDB2 MECOM	2.73e-04	10	50	2	GO:0140947
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	SETDB2 PRDM8 MECOM	6.60e-04	68	50	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	SETDB2 PRDM8 MECOM	6.89e-04	69	50	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	SETDB2 PRDM8 MECOM	7.49e-04	71	50	3	GO:0042054
GeneOntologyMolecularFunction	protein methyltransferase activity	SETDB2 PRDM8 MECOM	2.19e-03	103	50	3	GO:0008276
GeneOntologyMolecularFunction	N-methyltransferase activity	SETDB2 PRDM8 MECOM	2.31e-03	105	50	3	GO:0008170
GeneOntologyBiologicalProcess	negative regulation of DNA-templated transcription	SETDB2 ZNF263 PRDM8 ZSCAN10 DKK1 ZNF473 ZFP3 ZNF658 ZBTB25 ZNF202 MECOM ZNF205 ZNF488 CTNNB1 SNAI3 ZNF239	1.00e-07	1399	50	16	GO:0045892
GeneOntologyBiologicalProcess	negative regulation of RNA biosynthetic process	SETDB2 ZNF263 PRDM8 ZSCAN10 DKK1 ZNF473 ZFP3 ZNF658 ZBTB25 ZNF202 MECOM ZNF205 ZNF488 CTNNB1 SNAI3 ZNF239	1.15e-07	1413	50	16	GO:1902679
Domain	-	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	5.53e-35	679	48	32	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	1.12e-34	694	48	32	IPR013087
Domain	ZINC_FINGER_C2H2_2	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	3.84e-33	775	48	32	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	4.17e-33	777	48	32	PS00028
Domain	zf-C2H2	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	5.45e-33	693	48	31	PF00096
Domain	Znf_C2H2-like	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	9.04e-33	796	48	32	IPR015880
Domain	Znf_C2H2	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	1.29e-32	805	48	32	IPR007087
Domain	ZnF_C2H2	ZNF597 ZNF263 PRDM8 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	1.46e-32	808	48	32	SM00355
Domain	zf-C2H2_6	ZNF597 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF473 ZNF658 ZNF391 ZFP30 MECOM ZNF616 ZNF880 ZNF524 ZNF606 ZNF181	1.18e-18	314	48	17	PF13912
Domain	KRAB	ZNF597 ZNF263 ZNF527 ZNF586 ZNF555 ZNF473 ZNF658 ZFP30 ZNF436 ZNF202 ZNF205 ZNF616 ZNF880 ZNF606 ZFP69 ZNF181	3.07e-16	358	48	16	PS50805
Domain	KRAB	ZNF597 ZNF263 ZNF527 ZNF586 ZNF555 ZNF473 ZNF658 ZFP30 ZNF436 ZNF202 ZNF205 ZNF616 ZNF880 ZNF606 ZFP69 ZNF181	3.07e-16	358	48	16	PF01352
Domain	KRAB	ZNF597 ZNF263 ZNF527 ZNF586 ZNF555 ZNF473 ZNF658 ZFP30 ZNF436 ZNF202 ZNF205 ZNF616 ZNF880 ZNF606 ZFP69 ZNF181	4.95e-16	369	48	16	SM00349
Domain	KRAB	ZNF597 ZNF263 ZNF527 ZNF586 ZNF555 ZNF473 ZNF658 ZFP30 ZNF436 ZNF202 ZNF205 ZNF616 ZNF880 ZNF606 ZFP69 ZNF181	5.16e-16	370	48	16	IPR001909
Domain	SCAN_BOX	ZNF263 ZSCAN10 ZSCAN26 ZNF202 ZFP69	3.74e-07	58	48	5	PS50804
Domain	LCE	LCE3D LCE3E LCE3C	1.06e-05	17	48	3	PF14672
Domain	LCE	LCE3D LCE3E LCE3C	1.06e-05	17	48	3	IPR028205
Domain	SCAN	ZNF263 ZSCAN10 ZSCAN26 ZNF202	1.28e-05	56	48	4	SM00431
Domain	SCAN	ZNF263 ZSCAN10 ZSCAN26 ZNF202	1.47e-05	58	48	4	PF02023
Domain	SCAN_dom	ZNF263 ZSCAN10 ZSCAN26 ZNF202	1.47e-05	58	48	4	IPR003309
Domain	Retrov_capsid_C	ZNF263 ZSCAN10 ZSCAN26 ZNF202	1.58e-05	59	48	4	IPR008916
Domain	SPRR/LCE	LCE3E LCE3C	2.34e-03	28	48	2	IPR026075
Domain	SET	SETDB2 PRDM8	6.23e-03	46	48	2	SM00317
Domain	SET_dom	SETDB2 PRDM8	7.32e-03	50	48	2	IPR001214
Domain	SET	SETDB2 PRDM8	7.32e-03	50	48	2	PS50280
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF597 ZNF263 ZNF600 ZNF586 ZNF555 ZNF473 ZNF658 ZFP30 ZNF436 ZNF202 ZNF205 ZNF616 CTNNB1 ZNF606 ZFP69	4.77e-08	1387	31	15	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF263 ZNF473 ZFP30 ZNF202 ZNF205 ZNF616 CTNNB1 ZNF606 ZFP69	2.75e-05	768	31	9	MM14851
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	ZNF263 ZNF473 ZFP30 ZNF202 ZNF205 ZNF616 CTNNB1 ZNF606 ZFP69	2.50e-04	1022	31	9	MM15436
Pathway	WP_BMP2WNT4FOXO1_PATHWAY_IN_PRIMARY_ENDOMETRIAL_STROMAL_CELL_DIFFERENTIATION	DKK1 CTNNB1	3.60e-04	13	31	2	M39378
Pathway	REACTOME_FORMATION_OF_THE_NEPHRIC_DUCT	MECOM CTNNB1	7.01e-04	18	31	2	M48242
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF597 ZNF263 ZNF473 PRICKLE3 ZBTB25 ZFP30 ZNF436 ZNF202 JADE1 CTNNB1 ZNF524 ZNF623	3.09e-09	877	50	12	20211142
Pubmed	Molecular cloning and characterization of a novel mouse epidermal differentiation gene and its promoter.	LCE3D LCE3E LCE3C	1.12e-08	4	50	3	11350120
Pubmed	Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.	LCE3D LCE3E LCE3C	2.79e-08	5	50	3	11159194
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF263 ZNF473 PRICKLE3 ZNF202 ZNF205 ZNF616 JADE1 CTNNB1 ZNF623 ZNF239	1.92e-07	808	50	10	20412781
Pubmed	Zinc finger protein genes in the mouse genome.	ZFP3 ZFP30 MECOM	6.09e-07	12	50	3	1797234
Pubmed	Fate and plasticity of the epidermis in response to congenital activation of BRAF.	LCE3D LCE3E LCE3C	7.92e-07	13	50	3	25202828
Pubmed	p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.	LCE3D LCE3E LCE3C	1.55e-06	16	50	3	21930775
Pubmed	Rodent Lce gene clusters; new nomenclature, gene organization, and divergence of human and rodent genes.	LCE3D LCE3E LCE3C	1.55e-06	16	50	3	17410201
Pubmed	Differential expression of β-catenin and Dickkopf-1 in the third trimester placentas from normal and preeclamptic pregnancies: a comparative study.	DKK1 CTNNB1	2.03e-06	2	50	2	23452984
Pubmed	HIV-1 protein induced modulation of primary human osteoblast differentiation and function via a Wnt/β-catenin-dependent mechanism.	DKK1 CTNNB1	2.03e-06	2	50	2	23281130
Pubmed	Expression and clinical significance of von Hippel-Lindau downstream genes: Jade-1 and β-catenin related to renal cell carcinoma.	JADE1 CTNNB1	2.03e-06	2	50	2	22516360
Pubmed	DKK1 promotes migration and invasion of non-small cell lung cancer via β-catenin signaling pathway.	DKK1 CTNNB1	2.03e-06	2	50	2	28677426
Pubmed	Wnt/β-catenin signaling pathway in severe preeclampsia.	DKK1 CTNNB1	2.03e-06	2	50	2	29603045
Pubmed	Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas.	DKK1 CTNNB1	2.03e-06	2	50	2	19303159
Pubmed	Involvement of Wnt signaling in dermal fibroblasts.	DKK1 CTNNB1	2.03e-06	2	50	2	20042673
Pubmed	Prognostic value of Dickkopf-1 and ß-catenin expression according to the antitumor immunity of CD8-positive tumor-infiltrating lymphocytes in biliary tract cancer.	DKK1 CTNNB1	2.03e-06	2	50	2	35121803
Pubmed	Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.	LCE3D LCE3E LCE3C	4.22e-06	22	50	3	15854049
Pubmed	Differentially expressed late constituents of the epidermal cornified envelope.	LCE3D LCE3E LCE3C	4.85e-06	23	50	3	11698679
Pubmed	miR-33a-5p inhibits the progression of esophageal cancer through the DKK1-mediated Wnt/β-catenin pathway.	DKK1 CTNNB1	6.07e-06	3	50	2	34426559
Pubmed	Frizzled gene expression and negative regulation of canonical WNT-β-catenin signaling in mouse F9 teratocarcinoma cells.	DKK1 CTNNB1	6.07e-06	3	50	2	28177772
Pubmed	Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function.	DKK1 CTNNB1	6.07e-06	3	50	2	33085496
Pubmed	An autocrine mechanism for constitutive Wnt pathway activation in human cancer cells.	DKK1 CTNNB1	6.07e-06	3	50	2	15542433
Pubmed	E3 ubiquitin ligase Mule targets β-catenin under conditions of hyperactive Wnt signaling.	CTNNB1 HUWE1	6.07e-06	3	50	2	28137882
Pubmed	Wnt-independent activation of beta-catenin mediated by a Dkk1-Fz5 fusion protein.	DKK1 CTNNB1	6.07e-06	3	50	2	15694380
Pubmed	Wnt-beta-catenin signaling initiates taste papilla development.	DKK1 CTNNB1	6.07e-06	3	50	2	17128274
Pubmed	Eosinophil cationic protein enhances stabilization of β-catenin during cardiomyocyte differentiation in P19CL6 embryonal carcinoma cells.	RNASE3 CTNNB1	6.07e-06	3	50	2	23271121
Pubmed	β-catenin causes renal dysplasia via upregulation of Tgfβ2 and Dkk1.	DKK1 CTNNB1	6.07e-06	3	50	2	21436291
Pubmed	Dickkopf-1 inhibits thyroid cancer cell survival and migration through regulation of β-catenin/E-cadherin signaling.	DKK1 CTNNB1	6.07e-06	3	50	2	23261982
Pubmed	Protective effects of miR-29a on diabetic glomerular dysfunction by modulation of DKK1/Wnt/β-catenin signaling.	DKK1 CTNNB1	6.07e-06	3	50	2	27460630
Pubmed	Dickkopf-1 enhances migration of HEK293 cell by beta-catenin/E-cadherin degradation.	DKK1 CTNNB1	6.07e-06	3	50	2	19273195
Pubmed	Proliferation and migration mediated by Dkk-1/Wnt/beta-catenin cascade in a model of hepatocellular carcinoma cells.	DKK1 CTNNB1	6.07e-06	3	50	2	17964517
Pubmed	Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.	LCE3D LCE3E LCE3C	6.29e-06	25	50	3	23132931
Pubmed	Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.	LCE3D LCE3E LCE3C	6.29e-06	25	50	3	23906066
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	ZNF597 ZNF263 ZNF473 ZNF658 PRICKLE3 ZNF436 ZSCAN26 ZNF205 CTNNB1 ZNF239	6.88e-06	1203	50	10	29180619
Pubmed	Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.	LCE3D LCE3E LCE3C	7.10e-06	26	50	3	15454262
Pubmed	Wnt/beta-catenin signaling suppresses Rapsyn expression and inhibits acetylcholine receptor clustering at the neuromuscular junction.	DKK1 CTNNB1	1.21e-05	4	50	2	18541538
Pubmed	Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding.	DKK1 CTNNB1	1.21e-05	4	50	2	17507982
Pubmed	IFN-gamma mediates enhancement of HIV replication in astrocytes by inducing an antagonist of the beta-catenin pathway (DKK1) in a STAT 3-dependent manner.	DKK1 CTNNB1	1.21e-05	4	50	2	21562161
Pubmed	Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling.	DKK1 CTNNB1	1.21e-05	4	50	2	18606139
Pubmed	Activation of EVI1 transcription by the LEF1/β-catenin complex with p53-alteration in myeloid blast crisis of chronic myeloid leukemia.	MECOM CTNNB1	1.21e-05	4	50	2	27908728
Pubmed	An LRP5 receptor with internal deletion in hyperparathyroid tumors with implications for deregulated WNT/beta-catenin signaling.	DKK1 CTNNB1	1.21e-05	4	50	2	18044981
Pubmed	miR-590-3p promotes colon cancer cell proliferation via Wnt/β-catenin signaling pathway by inhibiting WIF1 and DKK1.	DKK1 CTNNB1	1.21e-05	4	50	2	29164578
Pubmed	FHL2 mediates dexamethasone-induced mesenchymal cell differentiation into osteoblasts by activating Wnt/beta-catenin signaling-dependent Runx2 expression.	DKK1 CTNNB1	1.21e-05	4	50	2	18653765
Pubmed	Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling.	DKK1 CTNNB1	1.21e-05	4	50	2	12050670
Pubmed	Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.	LCE3D LCE3E LCE3C	1.22e-05	31	50	3	20930145
Pubmed	Jade-1 inhibits Wnt signalling by ubiquitylating beta-catenin and mediates Wnt pathway inhibition by pVHL.	JADE1 CTNNB1	2.02e-05	5	50	2	18806787
Pubmed	The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes beta-catenin/TCF-mediated transcription.	DKK1 CTNNB1	2.02e-05	5	50	2	20019092
Pubmed	Analysis of association of LRP5, LRP6, SOST, DKK1, and CTNNB1 genes with bone mineral density in a Slovenian population.	DKK1 CTNNB1	2.02e-05	5	50	2	19898734
Pubmed	Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms.	DKK1 CTNNB1	2.02e-05	5	50	2	27918563
Pubmed	Rhou maintains the epithelial architecture and facilitates differentiation of the foregut endoderm.	DKK1 CTNNB1	2.02e-05	5	50	2	21903671
Pubmed	Upregulation of miR-501-5p activates the wnt/β-catenin signaling pathway and enhances stem cell-like phenotype in gastric cancer.	DKK1 CTNNB1	2.02e-05	5	50	2	27846906
Pubmed	FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.	DKK1 CTNNB1	2.02e-05	5	50	2	15592430
Pubmed	Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway.	DKK1 CTNNB1	2.02e-05	5	50	2	23164821
Pubmed	Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer.	DKK1 CTNNB1	3.03e-05	6	50	2	27045006
Pubmed	R-spondin 1/dickkopf-1/beta-catenin machinery is involved in testicular embryonic angiogenesis.	DKK1 CTNNB1	4.23e-05	7	50	2	25910078
Pubmed	Crooked tail (Cd) model of human folate-responsive neural tube defects is mutated in Wnt coreceptor lipoprotein receptor-related protein 6.	DKK1 CTNNB1	4.23e-05	7	50	2	16126904
Pubmed	The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression.	DKK1 CTNNB1	4.23e-05	7	50	2	24469828
Pubmed	Identification of SCAN dimerization domains in four gene families.	ZNF263 ZNF202	4.23e-05	7	50	2	11342224
Pubmed	TGIF governs a feed-forward network that empowers Wnt signaling to drive mammary tumorigenesis.	DKK1 CTNNB1	4.23e-05	7	50	2	25873176
Pubmed	TGFβ regulates epithelial-mesenchymal interactions through WNT signaling activity to control muscle development in the soft palate.	DKK1 CTNNB1	4.23e-05	7	50	2	24496627
Pubmed	Dkk1 in the peri-cloaca mesenchyme regulates formation of anorectal and genitourinary tracts.	DKK1 CTNNB1	5.64e-05	8	50	2	24479159
Pubmed	Expression and distribution of the zinc finger protein, SNAI3, in mouse ovaries and pre-implantation embryos.	CTNNB1 SNAI3	5.64e-05	8	50	2	29445069
Pubmed	Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix.	DKK1 CTNNB1	7.25e-05	9	50	2	18458345
Pubmed	Pax9's dual roles in modulating Wnt signaling during murine palatogenesis.	DKK1 CTNNB1	7.25e-05	9	50	2	32390226
Pubmed	The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis.	DKK1 CTNNB1	7.25e-05	9	50	2	17397822
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZNF473 ZFP30 ZNF436 ZNF616 ZNF606 ZNF623	7.37e-05	493	50	6	15368895
Pubmed	Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo.	DKK1 CTNNB1	9.05e-05	10	50	2	21924256
Pubmed	Aberrantly activated Wnt/β-catenin pathway co-receptors LRP5 and LRP6 regulate osteoblast differentiation in the developing coronal sutures of an Apert syndrome (Fgfr2S252W/+ ) mouse model.	DKK1 CTNNB1	9.05e-05	10	50	2	32822074
Pubmed	A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.	LCE3D LCE3E LCE3C	9.96e-05	62	50	3	26644517
Pubmed	Stringent requirement of a proper level of canonical WNT signalling activity for head formation in mouse embryo.	DKK1 CTNNB1	1.10e-04	11	50	2	21228006
Pubmed	Formation of multiple hearts in mice following deletion of beta-catenin in the embryonic endoderm.	DKK1 CTNNB1	1.10e-04	11	50	2	12194849
Pubmed	PRDM paralogs antagonistically balance Wnt/β-catenin activity during craniofacial chondrocyte differentiation.	MECOM CTNNB1	1.32e-04	12	50	2	35132438
Pubmed	Epithelial Wnt/β-catenin signaling regulates palatal shelf fusion through regulation of Tgfβ3 expression.	DKK1 CTNNB1	1.32e-04	12	50	2	21185284
Pubmed	AVE protein expression and visceral endoderm cell behavior during anterior-posterior axis formation in mouse embryos: Asymmetry in OTX2 and DKK1 expression.	DKK1 CTNNB1	1.32e-04	12	50	2	25910836
Pubmed	Molecular dynamics of Dkk4 modulates Wnt action and regulates meibomian gland development.	DKK1 CTNNB1	1.32e-04	12	50	2	27864382
Pubmed	GATA3 mediates nonclassical β-catenin signaling in skeletal cell fate determination and ectopic chondrogenesis.	DKK1 CTNNB1	1.32e-04	12	50	2	36449606
Pubmed	Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.	DKK1 CTNNB1	1.56e-04	13	50	2	15907834
Pubmed	Mesenchymal Wnt/β-catenin signaling limits tooth number.	DKK1 CTNNB1	1.56e-04	13	50	2	29437780
Pubmed	Levels of mesenchymal FGFR2 signaling modulate smooth muscle progenitor cell commitment in the lung.	DKK1 CTNNB1	1.82e-04	14	50	2	16989802
Pubmed	Apical ectodermal ridge morphogenesis in limb development is controlled by Arid3b-mediated regulation of cell movements.	DKK1 CTNNB1	2.10e-04	15	50	2	21307092
Pubmed	Single-Cell Analysis Reveals a Hair Follicle Dermal Niche Molecular Differentiation Trajectory that Begins Prior to Morphogenesis.	DKK1 CTNNB1	2.10e-04	15	50	2	30595533
Pubmed	WNT signals are required for the initiation of hair follicle development.	DKK1 CTNNB1	2.10e-04	15	50	2	12015971
Pubmed	HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.	DKK1 CTNNB1	2.40e-04	16	50	2	22007134
Pubmed	GLI3 repressor but not GLI3 activator is essential for mouse eye patterning and morphogenesis.	DKK1 CTNNB1	2.40e-04	16	50	2	30953627
Pubmed	Regional Control of Hairless versus Hair-Bearing Skin by Dkk2.	DKK1 CTNNB1	2.40e-04	16	50	2	30509557
Pubmed	Bmpr1a is required for proper migration of the AVE through regulation of Dkk1 expression in the pre-streak mouse embryo.	DKK1 CTNNB1	2.40e-04	16	50	2	20211162
Pubmed	Sustained epithelial beta-catenin activity induces precocious hair development but disrupts hair follicle down-growth and hair shaft formation.	DKK1 CTNNB1	2.40e-04	16	50	2	18256193
Pubmed	Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm.	DKK1 CTNNB1	2.40e-04	16	50	2	16256739
Pubmed	Decomposing a deterministic path to mesenchymal niche formation by two intersecting morphogen gradients.	DKK1 CTNNB1	2.40e-04	16	50	2	35421372
Pubmed	Ectodermal Wnt/β-catenin signaling shapes the mouse face.	DKK1 CTNNB1	2.72e-04	17	50	2	21087601
Pubmed	Epiblast-specific loss of HCF-1 leads to failure in anterior-posterior axis specification.	DKK1 CTNNB1	3.05e-04	18	50	2	27521049
Pubmed	Embryonic hair follicle fate change by augmented beta-catenin through Shh and Bmp signaling.	DKK1 CTNNB1	3.05e-04	18	50	2	19141668
Pubmed	Loss of Anks6 leads to YAP deficiency and liver abnormalities.	DKK1 CTNNB1	3.05e-04	18	50	2	32886109
Pubmed	A beta-catenin gradient links the clock and wavefront systems in mouse embryo segmentation.	DKK1 CTNNB1	3.05e-04	18	50	2	18157121
Pubmed	p120-catenin regulates WNT signaling and EMT in the mouse embryo.	DKK1 CTNNB1	3.41e-04	19	50	2	31371508
Pubmed	The Dkk1 dose is critical for eye development.	DKK1 CTNNB1	3.41e-04	19	50	2	21539829
Pubmed	Role of Epiprofin, a zinc-finger transcription factor, in limb development.	DKK1 CTNNB1	3.41e-04	19	50	2	19913006
Pubmed	Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.	DKK1 CTNNB1	3.41e-04	19	50	2	17002498
Pubmed	Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.	DKK1 CTNNB1	3.41e-04	19	50	2	27671872
Pubmed	Genome-wide association study of blood pressure and hypertension.	MECOM LDLRAD4	3.41e-04	19	50	2	19430479
Interaction	KRTAP10-6 interactions	ZNF600 ZNF672 LCE3D ZNF239 LCE3E LCE3C	7.01e-08	88	49	6	int:KRTAP10-6
Interaction	KRTAP2-3 interactions	ZNF672 LCE3D ZNF524 LCE3E LCE3C	3.39e-06	95	49	5	int:KRTAP2-3
Interaction	KRTAP2-4 interactions	ZNF672 LCE3D ZNF524 LCE3E LCE3C	4.58e-06	101	49	5	int:KRTAP2-4
Interaction	KRTAP10-7 interactions	ZSCAN10 ZNF555 LCE3D ZSCAN26 ZNF524 LCE3E LCE3C	6.51e-06	293	49	7	int:KRTAP10-7
Interaction	NOTCH2 interactions	ZNF263 ZNF672 ZNF555 ZNF628 ZNF341 ZSCAN26 ZNF888 ZNF623	7.48e-06	423	49	8	int:NOTCH2
Interaction	ZNF473 interactions	ZSCAN10 ZNF473 ZFP3 ZNF202	1.03e-05	56	49	4	int:ZNF473
Interaction	KRTAP10-9 interactions	ZNF473 LCE3D ZSCAN26 ZNF524 LCE3E LCE3C	2.50e-05	241	49	6	int:KRTAP10-9
Interaction	ZSCAN10 interactions	ZSCAN10 ZNF473 ZFP3	3.38e-05	26	49	3	int:ZSCAN10
Interaction	KRTAP10-1 interactions	DKK1 LCE3D ZSCAN26 LCE3E LCE3C	3.44e-05	153	49	5	int:KRTAP10-1
Interaction	ZFAT interactions	ZSCAN10 ZNF473 ZFP3	4.24e-05	28	49	3	int:ZFAT
Interaction	ZNF710 interactions	ZSCAN10 ZNF473 ZFP3	5.24e-05	30	49	3	int:ZNF710
Interaction	ZFP3 interactions	ZSCAN10 ZNF473 ZFP3	5.24e-05	30	49	3	int:ZFP3
Interaction	KRTAP4-1 interactions	LCE3D LCE3E LCE3C	5.79e-05	31	49	3	int:KRTAP4-1
Interaction	ZNF382 interactions	ZSCAN10 ZNF473 ZFP3	7.00e-05	33	49	3	int:ZNF382
Interaction	MDFI interactions	DKK1 LCE3D ZBTB25 ZNF205 ZNF524 LCE3E LCE3C	7.60e-05	430	49	7	int:MDFI
Interaction	ZNF513 interactions	ZSCAN10 ZNF473 ZFP3	7.67e-05	34	49	3	int:ZNF513
Interaction	ZFP28 interactions	ZSCAN10 ZNF473 ZFP3	9.90e-05	37	49	3	int:ZFP28
Interaction	MZF1 interactions	ZNF473 ZNF202 ZNF623	9.90e-05	37	49	3	int:MZF1
Interaction	TRIM28 interactions	ZNF263 ZNF600 ZNF527 DRG2 ZNF555 ZNF658 ZFP30 ZNF888 ZNF616 CTNNB1 HUWE1 ZNF181	1.63e-04	1474	49	12	int:TRIM28
Interaction	KRTAP17-1 interactions	LCE3D ZBTB25 LCE3C	2.16e-04	48	49	3	int:KRTAP17-1
Interaction	RGS17 interactions	LCE3D LCE3E LCE3C	2.16e-04	48	49	3	int:RGS17
Interaction	ZFP37 interactions	ZSCAN10 ZNF473 ZFP3	2.30e-04	49	49	3	int:ZFP37
Interaction	PRDM4 interactions	ZSCAN10 ZNF473 ZFP3	2.75e-04	52	49	3	int:PRDM4
Interaction	ZNF667 interactions	ZSCAN10 ZNF473 ZFP3	2.90e-04	53	49	3	int:ZNF667
Interaction	EFEMP2 interactions	ZNF263 LCE3D LCE3E LCE3C	3.32e-04	136	49	4	int:EFEMP2
Interaction	KRTAP10-8 interactions	ZNF473 LCE3D ZBTB25 ZNF524 LCE3E LCE3C	4.06e-04	401	49	6	int:KRTAP10-8
Interaction	ZNF287 interactions	ZSCAN10 ZNF473 ZFP3	4.19e-04	60	49	3	int:ZNF287
Interaction	CTCFL interactions	ZSCAN10 ZNF473 ZFP3	4.62e-04	62	49	3	int:CTCFL
Interaction	KRTAP5-2 interactions	LCE3D LCE3E LCE3C	4.62e-04	62	49	3	int:KRTAP5-2
Interaction	SLIT2 interactions	PRICKLE3 CTNNB1 HUWE1	4.84e-04	63	49	3	int:SLIT2
Interaction	MAGI3 interactions	MECOM CTNNB1 LDLRAD4	4.84e-04	63	49	3	int:MAGI3
Interaction	KRTAP5-4 interactions	LCE3D LCE3E LCE3C	4.84e-04	63	49	3	int:KRTAP5-4
Interaction	ZNF768 interactions	ZNF263 ZSCAN10 ZNF473 ZFP3	4.94e-04	151	49	4	int:ZNF768
Interaction	ZNF787 interactions	ZSCAN10 ZNF473 ZFP3	5.07e-04	64	49	3	int:ZNF787
Interaction	KRTAP10-11 interactions	LCE3D LCE3E LCE3C	5.07e-04	64	49	3	int:KRTAP10-11
Interaction	KRTAP5-11 interactions	LCE3D LCE3E LCE3C	5.55e-04	66	49	3	int:KRTAP5-11
Interaction	KRTAP5-3 interactions	LCE3D LCE3E LCE3C	5.55e-04	66	49	3	int:KRTAP5-3
Interaction	KRTAP10-5 interactions	LCE3D ZSCAN26 LCE3E LCE3C	6.14e-04	160	49	4	int:KRTAP10-5
Interaction	KRTAP4-12 interactions	LCE3D ZSCAN26 LCE3E LCE3C	6.28e-04	161	49	4	int:KRTAP4-12
Interaction	ZNF423 interactions	ZSCAN10 ZNF473 ZFP3	7.45e-04	73	49	3	int:ZNF423
Interaction	CHIC2 interactions	LCE3D LCE3E LCE3C	7.45e-04	73	49	3	int:CHIC2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF600 ZNF527 ZNF586 ZNF628 ZNF473 ZFP30 ZNF888 ZNF616 ZNF880 ZNF524 ZNF606 ZNF181	4.34e-09	1192	50	12	chr19q13
Cytoband	19q13.41	ZNF600 ZNF888 ZNF616 ZNF880	1.67e-06	78	50	4	19q13.41
Cytoband	16p13.3	ZNF597 ZNF263 ZSCAN10 ZNF205	1.48e-04	244	50	4	16p13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr16p13	ZNF597 ZNF263 ZSCAN10 ZNF205	1.20e-03	426	50	4	chr16p13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF597 ZNF263 ZNF600 ZNF527 ZNF672 ZNF586 ZSCAN10 ZNF555 ZNF628 ZNF473 ZFP3 ZNF658 ZNF391 ZNF341 ZBTB25 ZFP30 ZNF436 ZSCAN26 ZNF202 MECOM ZNF888 ZNF205 ZNF616 ZNF880 ZNF488 ZNF524 ZNF606 ZFP69 ZNF623 SNAI3 ZNF181 ZNF239	2.84e-36	718	43	32	28
GeneFamily	Late cornified envelope proteins	LCE3D LCE3E LCE3C	9.97e-06	18	43	3	627
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETDB2 PRDM8 MECOM	7.12e-05	34	43	3	487
GeneFamily	Zinc fingers C2H2-type\|PR/SET domain family	PRDM8 MECOM	7.35e-04	17	43	2	1197
ToppCell	COVID-CD4-CD4_Treg\|COVID / Condition, Cell_class and T cell subcluster	PRDM8 ZNF527 ZNF628 ZFP30 ZNF202	9.64e-07	159	50	5	037cd97c41eb2f91fd3f69bbb3ffdfd6c0158410
Disease	preeclampsia, hypertension, pregnancy-induced	PRDM8 MECOM	3.06e-04	16	48	2	EFO_0000668, MONDO_0024664
Disease	preeclampsia, parental genotype effect measurement	PRDM8 MECOM	3.06e-04	16	48	2	EFO_0000668, EFO_0005939
Disease	mean arterial pressure, unipolar depression	PRDM8 MECOM	1.25e-03	32	48	2	EFO_0003761, EFO_0006340
Disease	unipolar depression, systolic blood pressure	PRDM8 MECOM	1.41e-03	34	48	2	EFO_0003761, EFO_0006335
Disease	systolic blood pressure, alcohol consumption measurement	PRDM8 MECOM	2.67e-03	47	48	2	EFO_0006335, EFO_0007878
Disease	mean arterial pressure, alcohol consumption measurement	PRDM8 MECOM	3.26e-03	52	48	2	EFO_0006340, EFO_0007878
Disease	diastolic blood pressure, alcohol consumption measurement	PRDM8 MECOM	3.51e-03	54	48	2	EFO_0006336, EFO_0007878
Disease	Psoriasis	LCE3D LCE3C	3.91e-03	57	48	2	C0033860
Disease	Pustulosis of Palms and Soles	LCE3D LCE3C	3.91e-03	57	48	2	C0030246
Disease	carcinoma (implicated_via_orthology)	CTNNB1 SNAI3	4.90e-03	64	48	2	DOID:305 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RHIRSQHVGARAHAC	MECOM	336	Q03112
ARCTAGTLHNLSHHR	CTNNB1	211	P35222
HRGLTCNRSSTRHHE	GPR39	186	O43194
HNRTLNNCHRSRFRV	RNASE3	91	P12724
HRVLRNLCYHAQTRH	HUWE1	3206	Q7Z6Z7
HHNRHPSRRRHYQCD	PRICKLE3	521	O43900
RSHQHASQRAEHARS	GAB4	216	Q2WGN9
HHRHFRSHQCRRQRS	LCE3C	56	Q5T5A8
GCFLNHHRRHHRCRR	LCE3D	51	Q9BYE3
GCFLNHHRRHHRCRR	LCE3E	51	Q5T5B0
HHRRHHRCRRQRSNS	LCE3E	56	Q5T5B0
HHQASNSSRLHTCQR	DKK1	251	O94907
HARHQESCLHTTRTS	RGP1	286	Q92546
CNESFRERHHLSRHM	PRDM8	671	Q9NQV8
EHVCHRIHRSLASQF	DRG2	316	P55039
NSRSQHRRSSCSRHE	JADE1	26	Q6IE81
HCSRAFADRSNLRAH	SNAI3	241	Q3KNW1
RFDSRSNLRQHLHTH	ZBTB25	246	P24278
SFRHSSSFRRHQRVH	ZNF586	381	Q9NXT0
CHFQRRHAKTNSHSS	SETDB2	171	Q96T68
SFSRRAHLAEHQRAH	ZNF341	691	Q9BYN7
VCQEHFRERHHLSRH	ZNF488	321	Q96MN9
RHRLSLSNHQRFHTG	ZNF880	446	Q6PDB4
CHLCGHRFRQSSHLS	ZSCAN10	351	Q96SZ4
FRNSSNLARHRRSHT	ZSCAN10	616	Q96SZ4
FCRLSHLIQHQRTHS	ZNF436	231	Q9C0F3
AFRHRSNLVCHRRIH	ZNF616	361	Q08AN1
YSCRSHLRMHVRTHN	ZNF555	181	Q8NEP9
RQCAHLSRHQRIHTS	ZFP30	196	Q9Y2G7
HFSNHHSSSLLRCVR	SPEM2	111	Q0P670
HSRSLSQHQRAHTRA	ZNF672	406	Q499Z4
SQRTHLCAHQRIHTG	ZNF658	836	Q5TYW1
NFRRSSHLNRHQRIH	ZSCAN26	346	Q16670
VFRTQSQLACHHRLH	ZNF888	586	P0CJ79
CFSQRSNLIAHNRTH	ZNF205	456	O95201
KCSASFRQHSHLSRH	ZNF597	216	Q96LX8
FKRSSHLRRHCNIHA	ZNF524	151	Q96C55
FSQSSNLHIHRCIHT	ZNF239	356	Q16600
FCHSSDLIRHQRVHT	ZNF623	216	O75123
SQRSYLHCHRRLHSG	ZNF600	536	Q6ZNG1
FTCNSHLVRHLRTHT	ZNF202	406	O95125
SFSRRDHLVRHQRTH	ZNF202	601	O95125
FCCSSHLTRHQRIHT	ZNF181	386	Q2M3W8
FSQSCHLVAHRRIHT	ZNF606	661	Q8WXB4
FRHRSSLNQHHRTHT	ZFP69	336	Q49AA0
FSRSSHLLRHQSVHC	ZFP3	486	Q96NJ6
FRCHSSLSRHQRVHN	ZNF473	851	Q8WTR7
SQRTHLCAHQRIHTG	ZNF658B	596	Q4V348
AFRNTSCLRRHRHVH	ZNF628	546	Q5EBL2
FSCVSALRRHQRIHN	ZNF527	591	Q8NB42
AFCQSSTLIRHQHLH	ZNF391	341	Q9UJN7
FSCNSNLHRHQRTHT	ZNF263	471	O14978
SFLHHQRSNAHRGSR	LDLRAD4	266	O15165