Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Cys-rich_flank_reg_C	VASN RTN4R SLITRK3 TRIL SLITRK2 TLR4 TLR5 SLITRK5 RTN4RL2 GP5	7.28e-11	90	104	10	IPR000483
Domain	LRRCT	VASN RTN4R SLITRK3 TRIL SLITRK2 TLR4 TLR5 SLITRK5 RTN4RL2 GP5	7.28e-11	90	104	10	SM00082
Domain	LRR_8	VASN RTN4R SLITRK3 TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 RTN4RL2 GP5	2.93e-09	171	104	11	PF13855
Domain	Leu-rich_rpt_typical-subtyp	VASN RTN4R SLITRK3 TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 RTN4RL2 GP5	4.22e-09	177	104	11	IPR003591
Domain	LRR_TYP	VASN RTN4R SLITRK3 TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 RTN4RL2 GP5	4.22e-09	177	104	11	SM00369
Domain	LRR_1	VASN RTN4R SLITRK3 TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 RTN4RL2 GP5	3.85e-08	219	104	11	PF00560
Domain	LRRNT	VASN RTN4R SLITRK3 TRIL SLITRK2 SLITRK5 RTN4RL2 GP5	7.32e-08	98	104	8	IPR000372
Domain	LRRNT	VASN RTN4R SLITRK3 TRIL SLITRK2 SLITRK5 RTN4RL2 GP5	7.32e-08	98	104	8	SM00013
Domain	-	VASN RTN4R SLITRK3 TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 RTN4RL2 TBCEL GP5	2.28e-07	321	104	12	3.80.10.10
Domain	L_dom-like	VASN RTN4R SLITRK3 TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 RTN4RL2 TBCEL GP5	2.87e-07	328	104	12	IPR032675
Domain	Leu-rich_rpt	VASN RTN4R SLITRK3 TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 RTN4RL2 GP5	3.32e-07	271	104	11	IPR001611
Domain	LRRCT	VASN TRIL TLR4 TLR5 GP5	8.68e-07	32	104	5	PF01463
Domain	LRR	VASN RTN4R TRIL SLITRK2 LRRC27 TLR4 TLR5 SLITRK5 GP5	1.84e-06	201	104	9	PS51450
Domain	Dopey_N	DOP1A DOP1B	3.07e-05	2	104	2	IPR007249
Domain	Dopey_N	DOP1A DOP1B	3.07e-05	2	104	2	PF04118
Domain	Homez_dom	ZHX3 ZHX1	9.18e-05	3	104	2	IPR024578
Domain	Homez	ZHX3 ZHX1	9.18e-05	3	104	2	PF11569
Domain	RCC1	HERC2 HERC6 HERC5	1.78e-04	20	104	3	PF00415
Domain	RCC1_1	HERC2 HERC6 HERC5	2.07e-04	21	104	3	PS00625
Domain	RCC1_2	HERC2 HERC6 HERC5	2.07e-04	21	104	3	PS00626
Domain	RCC1_3	HERC2 HERC6 HERC5	2.07e-04	21	104	3	PS50012
Domain	Reg_chr_condens	HERC2 HERC6 HERC5	2.39e-04	22	104	3	IPR000408
Domain	-	HERC2 HERC6 HERC5	2.39e-04	22	104	3	2.130.10.30
Domain	RCC1/BLIP-II	HERC2 HERC6 HERC5	2.74e-04	23	104	3	IPR009091
Domain	Homeobox	ZHX3 HLX POU2F1 ZFHX4 ZFHX3 ZHX1 CUX1	3.36e-04	234	104	7	PF00046
Domain	HOMEOBOX_1	ZHX3 HLX POU2F1 ZFHX4 ZFHX3 ZHX1 CUX1	3.53e-04	236	104	7	PS00027
Domain	HOX	ZHX3 HLX POU2F1 ZFHX4 ZFHX3 ZHX1 CUX1	3.63e-04	237	104	7	SM00389
Domain	HOMEOBOX_2	ZHX3 HLX POU2F1 ZFHX4 ZFHX3 ZHX1 CUX1	3.81e-04	239	104	7	PS50071
Domain	Homeobox_dom	ZHX3 HLX POU2F1 ZFHX4 ZFHX3 ZHX1 CUX1	3.81e-04	239	104	7	IPR001356
Domain	HECT	HERC2 HERC6 HERC5	4.45e-04	27	104	3	PF00632
Domain	HECTc	HERC2 HERC6 HERC5	4.45e-04	27	104	3	SM00119
Domain	HECT_dom	HERC2 HERC6 HERC5	4.45e-04	27	104	3	IPR000569
Domain	HECT	HERC2 HERC6 HERC5	4.45e-04	27	104	3	PS50237
Domain	Abhydrolase_1	ABHD10 LIPK ABHD1	6.73e-04	31	104	3	PF00561
Domain	AB_hydrolase_1	ABHD10 LIPK ABHD1	8.10e-04	33	104	3	IPR000073
Domain	-	ZHX3 HLX POU2F1 ZFHX4 ZFHX3 ZHX1 CUX1	1.03e-03	283	104	7	1.10.10.60
Domain	R3H	YTHDC2 R3HDM2	1.08e-03	9	104	2	SM00393
Domain	R3H	YTHDC2 R3HDM2	1.63e-03	11	104	2	PS51061
Domain	R3H	YTHDC2 R3HDM2	1.63e-03	11	104	2	PF01424
Domain	-	YTHDC2 R3HDM2	1.63e-03	11	104	2	3.30.1370.50
Domain	ZnF_UBP	USP39 USP33	1.63e-03	11	104	2	SM00290
Domain	R3H_dom	YTHDC2 R3HDM2	1.63e-03	11	104	2	IPR001374
Domain	Homeodomain-like	ZHX3 HLX POU2F1 ZFHX4 ZFHX3 ZHX1 CUX1	2.57e-03	332	104	7	IPR009057
Domain	Znf_UBP	USP39 USP33	2.68e-03	14	104	2	IPR001607
Domain	zf-UBP	USP39 USP33	2.68e-03	14	104	2	PF02148
Domain	ZF_UBP	USP39 USP33	2.68e-03	14	104	2	PS50271
Domain	CNH	MINK1 CDC42BPB	2.68e-03	14	104	2	SM00036
Domain	CNH	MINK1 CDC42BPB	3.08e-03	15	104	2	PF00780
Domain	CNH	MINK1 CDC42BPB	3.08e-03	15	104	2	PS50219
Domain	CNH_dom	MINK1 CDC42BPB	3.08e-03	15	104	2	IPR001180
Domain	LRRNT	VASN SLITRK2 SLITRK5	3.21e-03	53	104	3	PF01462
Domain	Homeobox_CS	HLX POU2F1 ZFHX4 ZFHX3 CUX1	3.86e-03	186	104	5	IPR017970
Domain	-	ABHD10 YTHDC2 LIPK ABHD1	4.41e-03	119	104	4	3.40.50.1820
Domain	AB_hydrolase	ABHD10 YTHDC2 LIPK ABHD1	4.41e-03	119	104	4	IPR029058
Pubmed	Human transcription factor protein interaction networks.	ZHX3 BICRA UBR4 ETV4 POU2F1 E2F3 R3HDM2 SMG5 WASHC2A UBN1 ZFHX4 SYNE2 MARF1 ZFHX3 HERC2 ZHX1 CUX1 DCP1A PPP6R3	6.05e-08	1429	106	19	35140242
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	BICRA UBR4 ANKLE1 SMG5 ATG2A FHIP1B TEP1 WASHC2A CDC42BPB SLC25A22 UBN1 SLC16A5 BAMBI HERC2 IQGAP3 AGAP3	2.45e-07	1105	106	16	35748872
Pubmed	Identification and characterization of Slitrk, a novel neuronal transmembrane protein family controlling neurite outgrowth.	SLITRK3 SLITRK2 SLITRK5	5.47e-07	6	106	3	14550773
Pubmed	Differential expression of Slitrk family members in the mouse nervous system.	SLITRK3 SLITRK2 SLITRK5	5.47e-07	6	106	3	19924824
Pubmed	Human SLITRK family genes: genomic organization and expression profiling in normal brain and brain tumor tissue.	SLITRK3 SLITRK2 SLITRK5	5.47e-07	6	106	3	14557068
Pubmed	Molecular reclassification of Crohn's disease by cluster analysis of genetic variants.	POU2F1 CCNY TLR4 HERC2	6.90e-07	23	106	4	20886065
Pubmed	Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases.	SLITRK3 SLITRK2 SLITRK5	9.55e-07	7	106	3	23345436
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	MINK1 SLITRK3 CDC42BPB CCNY CDKL5 PROM1 SLITRK2 PPP3CB ANO6 MAPK13 GAB1	1.40e-06	569	106	11	30639242
Pubmed	Genetic risk profiling and prediction of disease course in Crohn's disease patients.	POU2F1 CCNY TLR4 HERC2	1.58e-06	28	106	4	19422935
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CA11 VIM UBR4 ASH1L CHD9 E2F3 SMG5 CDC42BPB PPP3CB RNF38 HERC2 CUX1 USP33 DOP1B ZNF292 AGAP3	1.78e-06	1285	106	16	35914814
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	VIM MCMBP EMC1 MINK1 SYNE2 SIK2 CNOT4 BICC1 GAB1 DOP1A DCP1A DOP1B AGAP3	2.29e-06	861	106	13	36931259
Pubmed	Inhibitory activity of myelin-associated glycoprotein on sensory neurons is largely independent of NgR1 and NgR2 and resides within Ig-Like domains 4 and 5.	RTN4R RTN4RL2	9.20e-06	2	106	2	19367338
Pubmed	Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori.	TLR4 TLR5	9.20e-06	2	106	2	16044857
Pubmed	Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria.	TLR4 TLR5	9.20e-06	2	106	2	16891416
Pubmed	Missense mutation of the reticulon-4 receptor alters spatial memory and social interaction in mice.	RTN4R RTN4RL2	9.20e-06	2	106	2	21645550
Pubmed	Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells.	TLR4 TLR5	9.20e-06	2	106	2	16829963
Pubmed	Toll-like receptors 4 and 5 induce distinct types of vasculitis.	TLR4 TLR5	9.20e-06	2	106	2	19150884
Pubmed	Decreased expression of Toll-like receptor 4 and 5 during progression of prostate transformation in transgenic adenocarcinoma of mouse prostate mice.	TLR4 TLR5	9.20e-06	2	106	2	25797291
Pubmed	Toll-like Receptors 4 and 5 Cooperatively Initiate the Innate Immune Responses to Uropathogenic Escherichia coli Infection in Mouse Epididymal Epithelial Cells.	TLR4 TLR5	9.20e-06	2	106	2	26819479
Pubmed	The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers.	ZFHX4 ZFHX3	9.20e-06	2	106	2	10873665
Pubmed	The GM-CSF Released by Airway Epithelial Cells Orchestrates the Mucosal Adjuvant Activity of Flagellin.	TLR4 TLR5	9.20e-06	2	106	2	33008952
Pubmed	Cell-surface Vimentin: A mislocalized protein for isolating csVimentin(+) CD133(-) novel stem-like hepatocellular carcinoma cells expressing EMT markers.	VIM PROM1	9.20e-06	2	106	2	25487874
Pubmed	Porcine Toll-like receptors: the front line of pathogen monitoring and possible implications for disease resistance.	TLR4 TLR5	9.20e-06	2	106	2	18590761
Pubmed	Association of TLR4 and TLR5 gene polymorphisms with Graves' disease in Chinese Cantonese population.	TLR4 TLR5	9.20e-06	2	106	2	24830583
Pubmed	Morphogenesis in Aspergillus nidulans requires Dopey (DopA), a member of a novel family of leucine zipper-like proteins conserved from yeast to humans.	DOP1A DOP1B	9.20e-06	2	106	2	10931277
Pubmed	TLR4 Deficiency Protects against Hepatic Fibrosis and Diethylnitrosamine-Induced Pre-Carcinogenic Liver Injury in Fibrotic Liver.	ABCB4 TLR4	9.20e-06	2	106	2	27391331
Pubmed	TRIL, a functional component of the TLR4 signaling complex, highly expressed in brain.	TRIL TLR4	9.20e-06	2	106	2	19710467
Pubmed	Expression and functional analysis of toll-like receptors of peripheral blood cells in asthmatic patients: implication for immunopathological mechanism in asthma.	TLR4 TLR5	9.20e-06	2	106	2	19067129
Pubmed	Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5.	TLR4 TLR5	9.20e-06	2	106	2	20952467
Pubmed	Toll-like receptor triggering in cord blood mesenchymal stem cells.	TLR4 TLR5	9.20e-06	2	106	2	20196781
Pubmed	Nogo-receptors NgR1 and NgR2 do not mediate regulation of CD4 T helper responses and CNS repair in experimental autoimmune encephalomyelitis.	RTN4R RTN4RL2	9.20e-06	2	106	2	22096481
Pubmed	Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes.	TLR4 TLR5	9.20e-06	2	106	2	12794153
Pubmed	Lipopolysaccharide-Induced TRPA1 Upregulation in Trigeminal Neurons is Dependent on TLR4 and Vesicular Exocytosis.	TRPA1 TLR4	9.20e-06	2	106	2	37643860
Pubmed	Nogo receptor is involved in the adhesion of dendritic cells to myelin.	RTN4R RTN4RL2	9.20e-06	2	106	2	21906273
Pubmed	Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface.	RTN4R RTN4RL2	9.20e-06	2	106	2	24956133
Pubmed	Toll-like receptors -4 and -5 in oral and cutaneous squamous cell carcinomas.	TLR4 TLR5	9.20e-06	2	106	2	25047824
Pubmed	The E3 ligase HERC5 promotes antimycobacterial responses in macrophages by ISGylating the phosphatase PTEN.	HERC6 HERC5	9.20e-06	2	106	2	37279284
Pubmed	Gene Expression Profiling of Toll-Like Receptor 4 and 5 in Peripheral Blood Mononuclear Cells in Rheumatic Disorders: Ankylosing Spondylitis and Rheumatoid Arthritis.	TLR4 TLR5	9.20e-06	2	106	2	26996117
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	MCMBP EMC1 MINK1 UBR4 SPART WASHC2A CDC42BPB ANO6 SYNE2 SIK2 HERC2 CUX1 GAB1 HERC5 USP33 PPP6R3	1.12e-05	1487	106	16	33957083
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	BICRA MINK1 ASH1L CHD9 E2F3 SLITRK3 TEP1 CDC42BPB CCNY LRRC27 ZFHX3 TMEM143 SLC4A5 CUX1 DOP1A AGAP3	1.14e-05	1489	106	16	28611215
Pubmed	Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.	ZHX3 SLITRK3 SLITRK2 ZFHX4 SLITRK5 TCF25 CUX1	1.24e-05	251	106	7	29031500
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZHX3 POU2F1 CHD9 E2F3 UBN1 USP39 HERC2 ZHX1 CUX1 ZNF292	1.75e-05	608	106	10	36089195
Pubmed	Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.	VIM PROM1 CUX1	2.17e-05	18	106	3	17589506
Pubmed	Lis1-Nde1-dependent neuronal fate control determines cerebral cortical size and lamination.	VIM PROM1 CUX1	2.17e-05	18	106	3	18469343
Pubmed	The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.	UBR4 CHD9 WASHC2A CLOCK ZFHX4 IQGAP3 CUX1	2.63e-05	282	106	7	23667531
Pubmed	Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia.	TLR4 TLR5	2.76e-05	3	106	2	21455638
Pubmed	Attenuated TLRs in middle ear mucosa contributes to susceptibility of chronic suppurative otitis media.	TLR4 TLR5	2.76e-05	3	106	2	24882571
Pubmed	Activation of enteroendocrine cells via TLRs induces hormone, chemokine, and defensin secretion.	TLR4 TLR5	2.76e-05	3	106	2	17371986
Pubmed	Expression and prognostic significance of zinc fingers and homeoboxes family members in renal cell carcinoma.	ZHX3 ZHX1	2.76e-05	3	106	2	28152006
Pubmed	Circular RNA circZNF292 regulates H2 O2 -induced injury in human lens epithelial HLE-B3 cells depending on the regulation of the miR-222-3p/E2F3 axis.	E2F3 ZNF292	2.76e-05	3	106	2	33851769
Pubmed	NudC-like protein 2 restrains centriole amplification by stabilizing HERC2.	HERC2 USP33	2.76e-05	3	106	2	31427565
Pubmed	Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide.	TLR4 TLR5	2.76e-05	3	106	2	20566829
Pubmed	Increased Expression of Toll-Like Receptors 4, 5, and 9 in Small Bowel Mucosa from Patients with Irritable Bowel Syndrome.	TLR4 TLR5	2.76e-05	3	106	2	28246611
Pubmed	TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.	TRPA1 TLR4	2.76e-05	3	106	2	24445575
Pubmed	Degradation of the deubiquitinating enzyme USP33 is mediated by p97 and the ubiquitin ligase HERC2.	HERC2 USP33	2.76e-05	3	106	2	24855649
Pubmed	The nogo receptor family restricts synapse number in the developing hippocampus.	RTN4R RTN4RL2	2.76e-05	3	106	2	22325200
Pubmed	Intestinal epithelial cell toll-like receptor 5 regulates the intestinal microbiota to prevent low-grade inflammation and metabolic syndrome in mice.	TLR4 TLR5	2.76e-05	3	106	2	25172014
Pubmed	The presence of functionally relevant toll-like receptor polymorphisms does not significantly correlate with development or outcome of sepsis.	TLR4 TLR5	2.76e-05	3	106	2	21721932
Pubmed	Ligand-induced differential cross-regulation of Toll-like receptors 2, 4 and 5 in intestinal epithelial cells.	TLR4 TLR5	2.76e-05	3	106	2	17493681
Pubmed	Novel NOD2 haplotype strengthens the association between TLR4 Asp299gly and Crohn's disease in an Australian population.	TLR4 TLR5	2.76e-05	3	106	2	18213697
Pubmed	TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity.	TLR4 TLR5	2.76e-05	3	106	2	21182074
Pubmed	ExoS and ExoT ADP ribosyltransferase activities mediate Pseudomonas aeruginosa keratitis by promoting neutrophil apoptosis and bacterial survival.	TLR4 TLR5	2.76e-05	3	106	2	22250085
Pubmed	Association of toll-like receptor 4, 5 and 10 polymorphisms with Helicobacter pylori-positive peptic ulcer disease in a center in Jordan.	TLR4 TLR5	2.76e-05	3	106	2	34420402
Pubmed	Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin.	TLR4 TLR5	2.76e-05	3	106	2	18566425
Pubmed	Polymorphisms in toll-like receptors 2, 4 and 5 are associated with Legionella pneumophila infection.	TLR4 TLR5	2.76e-05	3	106	2	23526294
Pubmed	Agenesis of the corpus callosum in Nogo receptor deficient mice.	RTN4R RTN4RL2	2.76e-05	3	106	2	27339102
Pubmed	LPS/TLR4 Signaling Enhances TGF-β Response Through Downregulating BAMBI During Prostatic Hyperplasia.	TLR4 BAMBI	2.76e-05	3	106	2	27243216
Pubmed	Toll-like receptor stimulation differentially regulates vasoactive intestinal peptide type 2 receptor in macrophages.	TLR4 TLR5	2.76e-05	3	106	2	20196778
Pubmed	Toll-like receptor genetic variants are associated with Gram-negative infections in VLBW infants.	TLR4 TLR5	2.76e-05	3	106	2	23867959
Pubmed	The association of variations in TLR genes and spontaneous immune control of hepatitis B virus.	TLR4 TLR5	2.76e-05	3	106	2	29276096
Pubmed	Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene.	ETV4 ZHX1	2.76e-05	3	106	2	12527199
Pubmed	Association between TLR2, TLR4, and TLR5 genetic variants and the risk of hepatocellular carcinoma in Moroccan population.	TLR4 TLR5	2.76e-05	3	106	2	37330637
Pubmed	Human MARF1 is an endoribonuclease that interacts with the DCP1:2 decapping complex and degrades target mRNAs.	MARF1 DCP1A	2.76e-05	3	106	2	30364987
Pubmed	An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke.	RTN4R RTN4RL2	2.76e-05	3	106	2	21057507
Pubmed	TLR5 participates in the TLR4 receptor complex and promotes MyD88-dependent signaling in environmental lung injury.	TLR4 TLR5	2.76e-05	3	106	2	31989925
Pubmed	Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.	RTN4R RTN4RL2	2.76e-05	3	106	2	18411262
Pubmed	Nogo receptor-vimentin interaction: a novel mechanism for the invasive activity of glioblastoma multiforme.	VIM RTN4R	2.76e-05	3	106	2	31649250
Pubmed	Toll-like receptor (TLR2, TLR4 and TLR5) gene polymorphisms and Helicobacter pylori infection in children with and without duodenal ulcer.	TLR4 TLR5	2.76e-05	3	106	2	18809506
Pubmed	Mon2, a relative of large Arf exchange factors, recruits Dop1 to the Golgi apparatus.	DOP1A DOP1B	2.76e-05	3	106	2	16301316
Pubmed	Activation of Toll-like receptor 5 in microglia modulates their function and triggers neuronal injury.	TLR4 TLR5	2.76e-05	3	106	2	32912327
Pubmed	TLR 5, but neither TLR2 nor TLR4, is involved in lung epithelial cell response to Burkholderia cenocepacia.	TLR4 TLR5	2.76e-05	3	106	2	18680520
Pubmed	Posttranslational ISGylation of NLRP3 by HERC enzymes facilitates inflammasome activation in models of inflammation.	HERC6 HERC5	2.76e-05	3	106	2	37651190
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	EMC1 MINK1 YTHDC2 WASHC5 MARF1 SIK2 TCF25 IQGAP3 CNOT4 USP33	3.09e-05	650	106	10	38777146
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	EMC1 SPART E2F3 SMG5 ATG2A CLOCK WASHC5 MED12L PPP6R3	3.62e-05	529	106	9	14621295
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ZHX3 R3HDM2 FHIP1B WASHC2A TRIL TCF25 USP33 DOP1B	3.65e-05	407	106	8	12693553
Pubmed	Confirmation of multiple Crohn's disease susceptibility loci in a large Dutch-Belgian cohort.	POU2F1 CCNY HERC2	4.06e-05	22	106	3	19174780
Pubmed	Slitrk4 is required for the development of inhibitory neurons in the fear memory circuit of the lateral amygdala.	SLITRK3 SLITRK2 SLITRK5	4.06e-05	22	106	3	38736483
Pubmed	TRPV4 activation triggers protective responses to bacterial lipopolysaccharides in airway epithelial cells.	TRPA1 TLR4	5.50e-05	4	106	2	29057902
Pubmed	Metagenomic analysis of the effects of toll-like receptors on bacterial infection in the peritoneal cavity following cecum ligation and puncture in mice.	TLR4 TLR5	5.50e-05	4	106	2	31348811
Pubmed	Deletion of TLR5 results in spontaneous colitis in mice.	TLR4 TLR5	5.50e-05	4	106	2	18008007
Pubmed	Damaged spermatogenic cells induce inflammatory gene expression in mouse Sertoli cells through the activation of Toll-like receptors 2 and 4.	TLR4 TLR5	5.50e-05	4	106	2	23123736
Pubmed	SIGIRR inhibits toll-like receptor 4, 5, 9-mediated immune responses in human airway epithelial cells.	TLR4 TLR5	5.50e-05	4	106	2	20364327
Pubmed	Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation.	TLR4 TLR5	5.50e-05	4	106	2	25378591
Pubmed	Behavioral abnormalities observed in Zfhx2-deficient mice.	ZFHX4 ZFHX3	5.50e-05	4	106	2	23300874
Pubmed	Amyloid Beta Peptides Block New Synapse Assembly by Nogo Receptor-Mediated Inhibition of T-Type Calcium Channels.	RTN4R RTN4RL2	5.50e-05	4	106	2	29024660
Pubmed	Source of biomass cooking fuel determines pulmonary response to household air pollution.	TLR4 TLR5	5.50e-05	4	106	2	24102120
Pubmed	Differences in the expression of TLRs and inflammatory cytokines in pre-eclamptic compared with healthy pregnant women.	TLR4 TLR5	5.50e-05	4	106	2	25549591
Pubmed	PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter.	CLOCK PIK3CB	5.50e-05	4	106	2	27022680
Pubmed	Toll-like receptor signaling in airborne Burkholderia thailandensis infection.	TLR4 TLR5	5.50e-05	4	106	2	19797072
Pubmed	Expression patterns and functions of toll-like receptors in mouse sertoli cells.	TLR4 TLR5	5.50e-05	4	106	2	18499758
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZHX3 ZFHX4 ZFHX3 ZHX1	2.28e-07	15	67	4	529
GeneFamily	WASH complex	WASHC2A WASHC5	2.01e-04	6	67	2	1331
GeneFamily	CD molecules\|Toll like receptors	TLR4 TLR5	5.97e-04	10	67	2	948
Coexpression	GSE37534_UNTREATED_VS_ROSIGLITAZONE_TREATED_CD4_TCELL_PPARG1_AND_FOXP3_TRASDUCED_UP	YTHDC2 CLOCK ZFHX4 SLC16A5 PIK3CB SYNE2 ZFHX3 DOP1A	1.42e-06	197	106	8	M8983
Coexpression	DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN	ZHX3 CHD9 E2F3 R3HDM2 CLOCK PPP3CB MARF1 CNOT4 CUX1 DOP1B ZNF292	3.04e-06	466	106	11	M13522
Coexpression	GSE3982_MAC_VS_TH1_UP	ZHX3 GPT CHD9 CLOCK PIK3CB TLR4 DOP1B	1.69e-05	199	106	7	M5510
Drug	tyrphostin AG-825; Down 200; 25.2uM; MCF7; HT_HG-U133A_EA	CHD9 E2F3 BAMBI CNOT4 CUX1 DOP1A SERTAD3 ZNF292	2.33e-06	185	105	8	1114_DN
Drug	Pivmecillinam hydrochloride [32887-03-9]; Up 200; 8.4uM; MCF7; HT_HG-U133A	VIM EMC1 MINK1 YTHDC2 TEP1 SLC16A5 DOP1B GP5	3.57e-06	196	105	8	3535_UP
Drug	Proscillaridin A [466-06-8]; Up 200; 7.6uM; MCF7; HT_HG-U133A	UBR4 POU2F1 TCF25 CNOT4 SERTAD3 DCP1A ZNF292	9.48e-06	160	105	7	4404_UP
Drug	Lanatoside C [17575-22-3]; Up 200; 4uM; MCF7; HT_HG-U133A	ASH1L YTHDC2 TCF25 CNOT4 SERTAD3 DCP1A ZNF292	1.11e-05	164	105	7	3963_UP
Drug	Sparteine (-) [90-39-1]; Down 200; 17uM; MCF7; HT_HG-U133A	SPART PIK3CB MAPK13 UTY CNOT4 GAB1 HERC5	3.29e-05	194	105	7	4391_DN
Drug	Colchicine [64-86-8]; Down 200; 10uM; MCF7; HT_HG-U133A	VIM ZHX3 ASH1L YTHDC2 UTY CNOT4 HERC5	3.63e-05	197	105	7	5675_DN
Drug	Fenspiride hydrochloride [5053-08-7]; Up 200; 13.4uM; PC3; HT_HG-U133A	CA11 ZHX3 UBE2NL ASH1L TEP1 UTY CNOT4	3.75e-05	198	105	7	2106_UP
Drug	Triamterene [396-01-0]; Down 200; 15.8uM; PC3; HT_HG-U133A	MCMBP MINK1 HLX SPART TEP1 SLITRK5 SERTAD3	3.75e-05	198	105	7	7307_DN
Drug	Niacin [59-67-6]; Down 200; 32.4uM; MCF7; HT_HG-U133A	ZHX3 EMC1 MINK1 SMG5 TLR5 HERC5 TBCEL	3.87e-05	199	105	7	3381_DN
Drug	Thiamphenicol [15318-45-3]; Down 200; 11.2uM; PC3; HT_HG-U133A	MCMBP MINK1 ASH1L HLX CNOT4 ZNF292 VEGFB	3.87e-05	199	105	7	7274_DN
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; HL60; HT_HG-U133A	CA11 EMC1 UBR4 GPT SLITRK3 ABCB4 TBCEL	3.87e-05	199	105	7	6153_UP
Drug	Spironolactone [52-01-7]; Down 200; 9.6uM; PC3; HT_HG-U133A	TEP1 PIK3CB SLITRK5 ZFHX3 HERC6 UTY CNOT4	3.87e-05	199	105	7	5781_DN
Disease	primary immunodeficiency disease (implicated_via_orthology)	TLR4 TLR5	3.40e-05	3	100	2	DOID:612 (implicated_via_orthology)
Disease	synophrys measurement	ZFHX4 TCF25 HERC2 PPP6R3	8.56e-05	68	100	4	EFO_0007906
Disease	glucose metabolism disease (implicated_via_orthology)	PIK3CB TLR4 TLR5	1.16e-04	28	100	3	DOID:4194 (implicated_via_orthology)
Disease	bipolar disorder (implicated_via_orthology)	ETV4 CLOCK	2.36e-04	7	100	2	DOID:3312 (implicated_via_orthology)
Disease	Prostatic Neoplasms	VIM ACRBP ASH1L ETV4 PIK3CB TLR4 TLR5 ZFHX3 ZNF292	2.50e-04	616	100	9	C0033578
Disease	Malignant neoplasm of prostate	VIM ACRBP ASH1L ETV4 PIK3CB TLR4 TLR5 ZFHX3 ZNF292	2.50e-04	616	100	9	C0376358
Disease	IGF-1 measurement	ZHX3 TICRR HLX E2F3 R3HDM2 SYNE2 DOP1B CCDC33	2.60e-04	488	100	8	EFO_0004627
Disease	Neurodevelopmental Disorders	ASH1L CDC42BPB CDKL5 ZNF292	2.88e-04	93	100	4	C1535926
Disease	ankylosing spondylitis (is_marker_for)	TLR4 TLR5	5.03e-04	10	100	2	DOID:7147 (is_marker_for)
Disease	collagen disease (implicated_via_orthology)	TLR4 TLR5	7.34e-04	12	100	2	DOID:854 (implicated_via_orthology)
Disease	obesity (implicated_via_orthology)	ETV4 ZFHX4 TLR4 MED12L ZFHX3	8.42e-04	215	100	5	DOID:9970 (implicated_via_orthology)
Disease	Adenocarcinoma Of Esophagus	SPART TLR4	1.01e-03	14	100	2	C0279628
Disease	diabetic neuropathy (implicated_via_orthology)	TRPA1 TLR4	1.01e-03	14	100	2	DOID:9743 (implicated_via_orthology)
Disease	Malignant neoplasm of breast	VIM UBR4 ETV4 POU2F1 PIK3CB SYNE2 HERC2 CUX1 GAB1 DOP1A VEGFB	1.04e-03	1074	100	11	C0006142
Disease	Down syndrome (implicated_via_orthology)	DOP1A DOP1B	1.16e-03	15	100	2	DOID:14250 (implicated_via_orthology)
Disease	Early infantile epileptic encephalopathy with suppression bursts	SLC25A22 CDKL5	1.32e-03	16	100	2	C0393706
Disease	sphingomyelin 14:0 measurement	SYNE2 ZFHX3	1.50e-03	17	100	2	EFO_0010390
Disease	perinatal necrotizing enterocolitis (biomarker_via_orthology)	TLR4 TLR5	1.50e-03	17	100	2	DOID:8677 (biomarker_via_orthology)
Disease	S-6-hydroxywarfarin measurement	MINK1 CHD9 LIPK CCNY PROM1 ZFHX3	1.61e-03	368	100	6	EFO_0803326
Disease	atrial fibrillation	BICRA ZFHX4 SYNE2 ZFHX3 ADGRD2 ZNF292	1.68e-03	371	100	6	EFO_0000275
Disease	uridine diphosphate measurement	YTHDC2 CDKL5	2.08e-03	20	100	2	EFO_0010545
Disease	triglyceride measurement, low density lipoprotein cholesterol measurement	ZHX3 E2F3 R3HDM2 SYNE2	2.49e-03	166	100	4	EFO_0004530, EFO_0004611

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLSIQALLNAPNPDD	UBE2NL	106	Q5JXB2
LALCVNPDLLSSPNF	GPT	86	P24298
PPQQFALSNSAAIRA	AGAP3	21	Q96P47
DSSRQALAAPLLNLP	ASH1L	2461	Q9NR48
LNARLQALTLTPPNA	ANKLE1	271	Q8NAG6
ENFLTPNNSKALPTL	CCDC33	571	Q8N5R6
QAALDPALKQAPLSQ	CUX1	721	P39880
LLLPLAPAAAQDSTQ	ACRBP	16	Q8NEB7
PPAQLFQLQARSAAL	BTBD17	261	A6NE02
DLALALPSENLPQFQ	DOP1A	2306	Q5JWR5
FQSLSGNSRPLQPLA	CA11	281	O75493
LAEANNLSFPLEPLS	CCNY	281	Q8ND76
PNSLLNALNSSVSPL	BICC1	471	Q9H694
ASLIANQSPFRAPLN	DCP1A	366	Q9NPI6
PLTNPLLNLDNTDLF	ATG2A	351	Q2TAZ0
ALFSLAFPDNQRPAL	ETV4	426	P43268
FPSPLAAQNASLRLN	R3HDM2	936	Q9Y2K5
LSLPPSTQRLFLQNN	RTN4RL2	56	Q86UN3
SDNSNIPNSELLPFL	PAAT	321	Q9H8K7
VASFPLAPLLALVNN	ANO6	681	Q4KMQ2
FLSSPLRTLNQLPSQ	FHIP1B	721	Q8N612
QAALFAAQARPSPQL	MED12L	1911	Q86YW9
NEASAILSPLNSNPR	HLX	231	Q14774
LQQQPLSAALRSLPA	MYO15A	2476	Q9UKN7
QGTSAPLLPLLQRFQ	HERC2	331	O95714
SLQAPADLPLAINTA	GAB1	131	Q13480
QRLPVPALQENFSSL	DOP1B	1771	Q9Y3R5
RRSLNSQPLNLALSP	ERVMER34-1	516	Q9H9K5
RPFDPSLLLAQATSN	CYP2S1	166	Q96SQ9
PLFANLNQLGRPASE	SLC25A22	206	Q9H936
GLSLFNLNVANLPFP	HERC6	766	Q8IVU3
SLSALDQFAGLLPNQ	ODAM	76	A1E959
TQLFPRASPQAADLL	MAPK13	271	O15264
LNLVNPNDPSLAFLS	CDC42BPB	1406	Q9Y5S2
GQRAPLANNLLPTSQ	GPR83	391	Q9NYM4
QNPSALLENLREPLA	IQGAP3	231	Q86VI3
VTAPLFLNPQNLSLL	POU2F1	671	P14859
NFSFPVNFSLSLLNP	ABCB4	91	P21439
DAAALNILALSPPAQ	GBA	126	P04062
LSLFNCNVANLPFPL	HERC5	776	Q9UII4
ALNTAAAANPLALNP	CHD9	2781	Q3L8U1
AAANPLALNPLLLSN	CHD9	2786	Q3L8U1
NLSPLASPANLLQQT	E2F3	396	O00716
CFSRLLDPQNSNSPL	BAMBI	51	Q13145
NPQLAAVLRSAALAP	GGT6	251	Q6P531
QRAAQLQLPQLPLAA	F8A1;	166	P23610
LSVNPAALNPASLQC	MS4A6E	71	Q96DS6
PNLLNRASPLAFNIA	MARF1	761	Q9Y4F3
LALNQNQLDFLPASL	GP5	151	P40197
AFSSLDRPQLPQVLQ	EMC1	821	Q8N766
QPLSPFNLGATLQSL	ESRG	101	Q1W209
LPAENKAFASNLPTL	BICRA	1031	Q9NZM4
AARANSLQLLSPQPG	CDKL5	636	O76039
FDSLPLAALLNQQFL	PPP3CB	191	P16298
SPAAILDNSPAFLNV	SASS6	111	Q6UVJ0
LNSLNLSSPFDLNFP	MCMBP	216	Q9BTE3
PFPILRSTDLNNNKS	P2RY10	166	O00398
SLQDQPTRNLAAFPA	MINK1	601	Q8N4C8
NNLSALPTEALAPLR	RTN4R	236	Q9BZR6
SPNLLIADNPQLSAL	UTY	716	O14607
VRLQSLFPLLPSDQN	RNF38	26	Q9H0F5
FRLAPTFSNLLLQPT	SMG5	581	Q9UPR3
ANAVLQALSNVPPLR	USP39	236	Q53GS9
FLQNSSVLDRLPQPA	SYNE2	5446	Q8WXH0
QLFNALTLFNLAQDP	TMEM120A	286	Q9BXJ8
NLSLGLPAAQPQNTF	LRRC27	501	Q9C0I9
GFNNISELLPRPLNA	SLITRK3	396	O94933
LNNNLLRTLPTDAFA	SLITRK3	511	O94933
AKANSLPPGNLRNSL	PROM1	656	O43490
NDNLLLSLPSNVFRF	SLITRK2	166	Q9H156
NLAPAAPQLQDLASS	SIK2	631	Q9H0K1
EAAINRNSSNLPLPL	PIK3CB	301	P42338
SQGPNPDFQLLLSLR	PLPBP	191	O94903
TLQQLQAALRLAPAP	SERTAD3	61	Q9UJW9
LETPLNSLLFNQPLT	ABHD1	241	Q96SE0
QKTSLSFLNRPDLPN	ABHD10	51	Q9NUJ1
LFSVAAPALPNALQL	ADGRD2	161	Q7Z7M1
APALPNALQLRAFAE	ADGRD2	166	Q7Z7M1
PSTQLILSAAFPLQQ	CLOCK	796	O15516
NPTSNSNFLDLNLPP	CNOT4	516	O95628
NSLDTVLNRPPGFLQ	SPART	256	Q8N0X7
INPFQLDPATAAALA	ZFHX4	846	Q86UP3
ASALQALTQSPLLFQ	TICRR	1841	Q7Z2Z1
LLNLQDPFSSPLLSI	TRPA1	891	O75762
PLLRINQANSPDLLS	WASHC5	596	Q12768
PSLNINLLRFPNFTN	TRAPPC11	1091	Q7Z392
LEAQLRNQALPFPSN	TEP1	576	Q99973
PPLAGLLLDATNNFS	SLC16A5	381	O15375
ALEPLLAQANFSPLS	TMEM143	156	Q96AN5
DNLLSSLPNNLFRFV	SLITRK5	186	O94991
NNLLQALAPGTLAPL	TRIL	116	Q7L0X0
PSFLQLLAENRSPAF	ZNF292	1451	O60281
LLAENRSPAFLPNTF	ZNF292	1456	O60281
IPTYNAALDNNPLLL	ZHX1	286	Q9UKY1
ISLPLPNFSSLNLRE	VIM	411	P08670
APLAPDTNASLYNLL	SLC4A5	696	Q9BY07
LPSGVFQPLANLSNL	VASN	91	Q6EMK4
AALLQLAPAQAPVSQ	VEGFB	11	P49765
PLLLSINLNDLQFAA	XNDC1N	196	Q6ZNB5
LAINPAALLPTAASQ	WASHC2A	961	Q641Q2
PARLASNALQEPSSF	YTHDC2	1066	Q9H6S0
SLQSPLNFLAEQALA	UBN1	731	Q9NPG3
SRNQLLAPNPDVFVS	TLR5	556	O60602
LLLSLPAPASVQQQS	UBR4	2511	Q5T4S7
PEQLRALESSFAQNP	ZHX3	621	Q9H4I2
NLPFSTKNLDLSFNP	TLR4	51	O00206
LNDSPLNPLLASFFS	PPP6R3	111	Q5H9R7
NLSQLPNFAFSVPLA	TCF25	411	Q9BQ70
QLEFLNLSSNPLNLS	TBCEL	101	Q5QJ74
LASRIGENPFNLPLQ	TYRO3	616	Q06418
QALSNCPPLTQFFLD	USP33	201	Q8TEY7
LFDPSNPLLASQLLS	ZFHX3	2576	Q15911
NLPNNSLAFLLADSG	LIPK	96	Q5VXJ0