Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serine-type endopeptidase activity	MST1 TMPRSS9 MST1L KLKB1 CFB	1.60e-04	190	54	5	GO:0004252
GeneOntologyMolecularFunction	serine-type peptidase activity	MST1 TMPRSS9 MST1L KLKB1 CFB	2.39e-04	207	54	5	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	MST1 TMPRSS9 MST1L KLKB1 CFB	2.67e-04	212	54	5	GO:0017171
GeneOntologyMolecularFunction	U3 snoRNA binding	RRP9 TBL3	3.89e-04	11	54	2	GO:0034511
GeneOntologyMolecularFunction	calcium ion binding	THBS4 MEGF8 CAPN3 DGKA LTBP1 RET PKD1L2 NOTCH4	8.53e-04	749	54	8	GO:0005509
GeneOntologyMolecularFunction	endopeptidase activity	MST1 TMPRSS9 CAPN3 MST1L KLKB1 CFB	1.04e-03	430	54	6	GO:0004175
Domain	PAN	MST1 MST1L KLKB1	7.07e-07	7	52	3	PS50948
Domain	Pan_app	MST1 MST1L KLKB1	7.07e-07	7	52	3	IPR003609
Domain	PAN_1	MST1 MST1L KLKB1	7.07e-07	7	52	3	PF00024
Domain	Peptidase_S1A	MST1 TMPRSS9 MST1L KLKB1 CFB	1.54e-05	113	52	5	IPR001314
Domain	TRYPSIN_DOM	MST1 TMPRSS9 MST1L KLKB1 CFB	1.67e-05	115	52	5	PS50240
Domain	Tryp_SPc	MST1 TMPRSS9 MST1L KLKB1 CFB	1.82e-05	117	52	5	SM00020
Domain	Trypsin	MST1 TMPRSS9 MST1L KLKB1 CFB	2.14e-05	121	52	5	PF00089
Domain	Trypsin_dom	MST1 TMPRSS9 MST1L KLKB1 CFB	2.14e-05	121	52	5	IPR001254
Domain	Peptidase_S1_PA	MST1 TMPRSS9 MST1L KLKB1 CFB	2.32e-05	123	52	5	IPR009003
Domain	PAN_AP	MST1 MST1L	7.56e-05	5	52	2	SM00473
Domain	EGF_CA	THBS4 MEGF8 LTBP1 NOTCH4	9.58e-05	86	52	4	PF07645
Domain	EGF_Ca-bd_CS	THBS4 MEGF8 LTBP1 NOTCH4	1.53e-04	97	52	4	IPR018097
Domain	EGF_CA	THBS4 MEGF8 LTBP1 NOTCH4	1.65e-04	99	52	4	PS01187
Domain	ConA-like_dom	THBS4 NRXN2 BTNL3 TRIM68 HERC1	3.52e-04	219	52	5	IPR013320
Domain	EGF_CA	THBS4 MEGF8 LTBP1 NOTCH4	3.68e-04	122	52	4	SM00179
Domain	EGF-like_Ca-bd_dom	THBS4 MEGF8 LTBP1 NOTCH4	3.92e-04	124	52	4	IPR001881
Domain	EGF	THBS4 NRXN2 LTBP1 NOTCH4	4.16e-04	126	52	4	PF00008
Domain	EGF_3	THBS4 MEGF8 NRXN2 LTBP1 NOTCH4	4.85e-04	235	52	5	PS50026
Domain	EGF	THBS4 MEGF8 NRXN2 LTBP1 NOTCH4	4.85e-04	235	52	5	SM00181
Domain	EGF-like_dom	THBS4 MEGF8 NRXN2 LTBP1 NOTCH4	6.31e-04	249	52	5	IPR000742
Domain	EGF_1	THBS4 MEGF8 NRXN2 LTBP1 NOTCH4	7.02e-04	255	52	5	PS00022
Domain	EGF-like_CS	THBS4 MEGF8 NRXN2 LTBP1 NOTCH4	7.80e-04	261	52	5	IPR013032
Domain	EGF_2	THBS4 MEGF8 NRXN2 LTBP1 NOTCH4	8.35e-04	265	52	5	PS01186
Domain	Growth_fac_rcpt_	THBS4 MEGF8 LTBP1 NOTCH4	9.28e-04	156	52	4	IPR009030
Domain	Kringle	MST1 MST1L	1.01e-03	17	52	2	IPR000001
Domain	Kringle_CS	MST1 MST1L	1.01e-03	17	52	2	IPR018056
Domain	KRINGLE_2	MST1 MST1L	1.01e-03	17	52	2	PS50070
Domain	Kringle	MST1 MST1L	1.01e-03	17	52	2	PF00051
Domain	KRINGLE_1	MST1 MST1L	1.01e-03	17	52	2	PS00021
Domain	KR	MST1 MST1L	1.01e-03	17	52	2	SM00130
Domain	SPRY	BTNL3 TRIM68 HERC1	1.83e-03	87	52	3	SM00449
Domain	TRYPSIN_SER	TMPRSS9 KLKB1 CFB	2.02e-03	90	52	3	IPR033116
Domain	SPRY	BTNL3 TRIM68 HERC1	2.28e-03	94	52	3	PF00622
Domain	SPRY_dom	BTNL3 TRIM68 HERC1	2.28e-03	94	52	3	IPR003877
Domain	B30.2/SPRY	BTNL3 TRIM68 HERC1	2.35e-03	95	52	3	IPR001870
Domain	B302_SPRY	BTNL3 TRIM68 HERC1	2.35e-03	95	52	3	PS50188
Domain	ASX_HYDROXYL	MEGF8 LTBP1 NOTCH4	2.72e-03	100	52	3	PS00010
Domain	TRYPSIN_HIS	TMPRSS9 KLKB1 CFB	2.96e-03	103	52	3	IPR018114
Domain	TRYPSIN_SER	TMPRSS9 KLKB1 CFB	3.21e-03	106	52	3	PS00135
Domain	EGF-type_Asp/Asn_hydroxyl_site	MEGF8 LTBP1 NOTCH4	3.21e-03	106	52	3	IPR000152
Domain	TRYPSIN_HIS	TMPRSS9 KLKB1 CFB	3.30e-03	107	52	3	PS00134
Domain	Kringle-like	MST1 MST1L	3.57e-03	32	52	2	IPR013806
Domain	GPS	ADGRG2 PKD1L2	4.03e-03	34	52	2	SM00303
Domain	GPCR_2_secretin-like_CS	VIPR1 ADGRG2	4.03e-03	34	52	2	IPR017983
Domain	GPS	ADGRG2 PKD1L2	4.27e-03	35	52	2	PF01825
Domain	GPS	ADGRG2 PKD1L2	4.51e-03	36	52	2	PS50221
Domain	GPS	ADGRG2 PKD1L2	4.76e-03	37	52	2	IPR000203
Domain	SET	SMYD1 SUV39H1	5.82e-03	41	52	2	PF00856
Domain	PRY	BTNL3 TRIM68	6.10e-03	42	52	2	PF13765
Domain	SET	SMYD1 SUV39H1	7.28e-03	46	52	2	SM00317
Domain	PRY	BTNL3 TRIM68	7.90e-03	48	52	2	SM00589
Domain	PRY	BTNL3 TRIM68	7.90e-03	48	52	2	IPR006574
Domain	CUB	MEGF8 CSMD3	8.22e-03	49	52	2	PF00431
Pathway	REACTOME_SIGNALING_BY_MST1	MST1 MST1L	1.17e-04	6	40	2	MM15492
Pathway	BIOCARTA_MSP_PATHWAY	MST1 MST1L	1.63e-04	7	40	2	MM1580
Pathway	WP_MIR302367_PROMOTING_CARDIOMYOCYTE_PROLIFERATION	MST1 MST1L	2.17e-04	8	40	2	MM15986
Pubmed	Structure of the human D1F15S1A locus: a chromosome 1 locus with 97% identity to the chromosome 3 gene coding for hepatocyte growth factor-like protein.	MST1 MST1L	2.46e-06	2	55	2	10728827
Pubmed	Genetically selected Marchigian Sardinian alcohol-preferring (msP) rats: an animal model to study the neurobiology of alcoholism.	MST1 MST1L	2.46e-06	2	55	2	16961763
Pubmed	Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.	MST1 MST1L	2.46e-06	2	55	2	39253972
Pubmed	Mst1 regulates post-infarction cardiac injury through the JNK-Drp1-mitochondrial fission pathway.	MST1 MST1L	2.46e-06	2	55	2	29760744
Pubmed	Characterization of free alpha- and beta-chains of recombinant macrophage-stimulating protein.	MST1 KLKB1	2.46e-06	2	55	2	10068459
Pubmed	Cerebral ischemia-reperfusion is modulated by macrophage-stimulating 1 through the MAPK-ERK signaling pathway.	MST1 MST1L	2.46e-06	2	55	2	32017081
Pubmed	Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy.	MST1 MST1L	2.46e-06	2	55	2	30708325
Pubmed	Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.	MST1 MST1L	2.46e-06	2	55	2	24409221
Pubmed	Melatonin alleviates postinfarction cardiac remodeling and dysfunction by inhibiting Mst1.	MST1 MST1L	2.46e-06	2	55	2	27696525
Pubmed	Cloning, sequencing, and expression of human macrophage stimulating protein (MSP, MST1) confirms MSP as a member of the family of kringle proteins and locates the MSP gene on chromosome 3.	MST1 MST1L	2.46e-06	2	55	2	8393443
Pubmed	Hepatocyte-specific expression of the mouse hepatocyte growth factor-like protein.	MST1 MST1L	2.46e-06	2	55	2	8340069
Pubmed	Biological effects of targeted inactivation of hepatocyte growth factor-like protein in mice.	MST1 MST1L	2.46e-06	2	55	2	9486989
Pubmed	MSP is a negative regulator of inflammation and lipogenesis in ex vivo models of non-alcoholic steatohepatitis.	MST1 MST1L	2.46e-06	2	55	2	27609031
Pubmed	Hepatocyte growth factor-like protein is required for prostate tumor growth in the TRAMP mouse model.	MST1 MST1L	2.46e-06	2	55	2	24980820
Pubmed	Treatment with XMU-MP-1 erases hyperglycaemic memory in hearts of diabetic mice.	MST1 MST1L	2.46e-06	2	55	2	33887258
Pubmed	HGFL supports mammary tumorigenesis by enhancing tumor cell intrinsic survival and influencing macrophage and T-cell responses.	MST1 MST1L	2.46e-06	2	55	2	25938541
Pubmed	Mst1 deletion reduces hyperglycemia-mediated vascular dysfunction via attenuating mitochondrial fission and modulating the JNK signaling pathway.	MST1 MST1L	2.46e-06	2	55	2	31206688
Pubmed	Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.	MST1 MST1L	7.36e-06	3	55	2	27496379
Pubmed	Macrophage-stimulating protein cooperates with erythropoietin to induce colony formation and MAP kinase activation in primary erythroid progenitor cells.	MST1 MST1L	7.36e-06	3	55	2	12804176
Pubmed	Receptor tyrosine kinase Ron is expressed in mouse reproductive tissues during embryo implantation and is important in trophoblast cell function.	MST1 MST1L	7.36e-06	3	55	2	12606483
Pubmed	The Ron/STK receptor tyrosine kinase is essential for peri-implantation development in the mouse.	MST1 MST1L	7.36e-06	3	55	2	10225971
Pubmed	Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice.	MST1 MST1L	7.36e-06	3	55	2	36623453
Pubmed	Hippo Kinase MST1-Mediated Cell Metabolism Reprograms the Homeostasis and Differentiation of Granulocyte Progenitor Cells.	MST1 MST1L	7.36e-06	3	55	2	37184367
Pubmed	Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes.	MST1 MST1L	7.36e-06	3	55	2	38430683
Pubmed	Macrophage stimulating protein is a target-derived neurotrophic factor for developing sensory and sympathetic neurons.	MST1 MST1L	7.36e-06	3	55	2	12538524
Pubmed	Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes.	MST1 MST1L	7.36e-06	3	55	2	19339990
Pubmed	TRAF2 functions as an activator switch in the reactive oxygen species-induced stimulation of MST1.	MST1 MST1L	7.36e-06	3	55	2	26698664
Pubmed	CircRbms1 fosters MST1 mRNA and protein levels to motivate myocardial ischaemia-reperfusion injury via autophagic status.	MST1 MST1L	7.36e-06	3	55	2	38288506
Pubmed	The proto-oncogene RON is involved in development of epithelial, bone and neuro-endocrine tissues.	MST1 MST1L	7.36e-06	3	55	2	8545120
Pubmed	Hepatocyte growth factor-like protein is a positive regulator of early mammary gland ductal morphogenesis.	MST1 MST1L	7.36e-06	3	55	2	25049204
Pubmed	Characterization of the mouse cDNA and gene coding for a hepatocyte growth factor-like protein: expression during development.	MST1 MST1L	7.36e-06	3	55	2	1832957
Pubmed	Activation of pro-survival CaMK4β/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease.	MST1 MST1L	7.36e-06	3	55	2	25183307
Pubmed	MST1 mediates neuronal loss and cognitive deficits: A novel therapeutic target for Alzheimer's disease.	MST1 MST1L	7.36e-06	3	55	2	35525373
Pubmed	MST1 coordinately regulates autophagy and apoptosis in diabetic cardiomyopathy in mice.	MST1 MST1L	7.36e-06	3	55	2	27510910
Pubmed	Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition.	MST1 MST1L	7.36e-06	3	55	2	30063115
Pubmed	Combination of melatonin and irisin ameliorates lipopolysaccharide-induced cardiac dysfunction through suppressing the Mst1-JNK pathways.	MST1 MST1L	7.36e-06	3	55	2	31976559
Pubmed	Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury.	MST1 MST1L	7.36e-06	3	55	2	27218122
Pubmed	Over-expressed MST1 impaired spatial memory via disturbing neural oscillation patterns in mice.	MST1 MST1L	7.36e-06	3	55	2	32468668
Pubmed	Inhibition of endogenous Mst1 prevents apoptosis and cardiac dysfunction without affecting cardiac hypertrophy after myocardial infarction.	MST1 MST1L	7.36e-06	3	55	2	17395874
Pubmed	Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.	MST1 MST1L	7.36e-06	3	55	2	29127009
Pubmed	Mst1 Kinase Regulates the Actin-Bundling Protein L-Plastin To Promote T Cell Migration.	MST1 MST1L	7.36e-06	3	55	2	27465533
Pubmed	Genetic deletion of Mst1 alters T cell function and protects against autoimmunity.	MST1 MST1L	7.36e-06	3	55	2	24852423
Pubmed	Suramin protects hepatocytes from LPS-induced apoptosis by regulating mitochondrial stress and inactivating the JNK-Mst1 signaling pathway.	MST1 MST1L	7.36e-06	3	55	2	30771091
Pubmed	MST1 mediates the N-methyl-D-aspartate-induced excitotoxicity in mouse cortical neurons.	MST1 MST1L	7.36e-06	3	55	2	34967918
Pubmed	Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity.	MST1 MST1L	7.36e-06	3	55	2	38898027
Pubmed	WASP and Mst1 coregulate B-cell development and B-cell receptor signaling.	MST1 MST1L	7.36e-06	3	55	2	32045478
Pubmed	Impaired liver regeneration in aged mice can be rescued by silencing Hippo core kinases MST1 and MST2.	MST1 MST1L	7.36e-06	3	55	2	27940445
Pubmed	Mst1 regulates hepatic lipid metabolism by inhibiting Sirt1 ubiquitination in mice.	MST1 MST1L	1.47e-05	4	55	2	26903296
Pubmed	Glyceraldehyde-3-phosphate dehydrogenase interacts with proapoptotic kinase mst1 to promote cardiomyocyte apoptosis.	MST1 MST1L	1.47e-05	4	55	2	23527007
Pubmed	A cell-intrinsic role for Mst1 in regulating thymocyte egress.	MST1 MST1L	1.47e-05	4	55	2	19692642
Pubmed	Inhibition of TLR4-induced IκB kinase activity by the RON receptor tyrosine kinase and its ligand, macrophage-stimulating protein.	MST1 MST1L	1.47e-05	4	55	2	21078906
Pubmed	MST1 controls murine neutrophil homeostasis via the G-CSFR/STAT3 axis.	MST1 MST1L	1.47e-05	4	55	2	36618429
Pubmed	Melatonin protects against diabetic cardiomyopathy through Mst1/Sirt3 signaling.	MST1 MST1L	1.47e-05	4	55	2	28480597
Pubmed	Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion.	MST1 MST1L	1.47e-05	4	55	2	16892067
Pubmed	Hippo signaling pathway reveals a spatio-temporal correlation with the size of primordial follicle pool in mice.	MST1 MST1L	1.47e-05	4	55	2	25659841
Pubmed	Hyperglycemia-Induced Overexpression of PH Domain Leucine-Rich Repeat Protein Phosphatase 1 (PHLPP1) Compromises the Cardioprotective Effect of Ischemic Postconditioning Via Modulation of the Akt/Mst1 Pathway Signaling.	MST1 MST1L	1.47e-05	4	55	2	35715527
Pubmed	Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation.	MST1 MST1L	1.47e-05	4	55	2	26538561
Pubmed	MST1 functions as a key modulator of neurodegeneration in a mouse model of ALS.	MST1 MST1L	1.47e-05	4	55	2	23818595
Pubmed	Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.	MST1 MST1L	1.47e-05	4	55	2	25074980
Pubmed	RON (MST1R) and HGFL (MST1) Co-Overexpression Supports Breast Tumorigenesis through Autocrine and Paracrine Cellular Crosstalk.	MST1 MST1L	1.47e-05	4	55	2	35626096
Pubmed	Mammalian sterile 20-like kinase 1 suppresses lymphoma development by promoting faithful chromosome segregation.	MST1 MST1L	1.47e-05	4	55	2	22926556
Pubmed	OSM mitigates post-infarction cardiac remodeling and dysfunction by up-regulating autophagy through Mst1 suppression.	MST1 MST1L	1.47e-05	4	55	2	27825852
Pubmed	Treatment with Mammalian Ste-20-like Kinase 1/2 (MST1/2) Inhibitor XMU-MP-1 Improves Glucose Tolerance in Streptozotocin-Induced Diabetes Mice.	MST1 MST1L	1.47e-05	4	55	2	32987643
Pubmed	The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development.	MST1 MST1L	1.47e-05	4	55	2	30386341
Pubmed	MST1 deficiency promotes B cell responses by CD4+ T cell-derived IL-4, resulting in hypergammaglobulinemia.	MST1 MST1L	1.47e-05	4	55	2	28527887
Pubmed	Mst1 directs Myosin IIa partitioning of low and higher affinity integrins during T cell migration.	MST1 MST1L	1.47e-05	4	55	2	25133611
Pubmed	LncRNA SNHG17 knockdown promotes Parkin-dependent mitophagy and reduces apoptosis of podocytes through Mst1.	MST1 MST1L	1.47e-05	4	55	2	32627655
Pubmed	Macrophage MST1/2 Disruption Impairs Post-Infarction Cardiac Repair via LTB4.	MST1 MST1L	1.47e-05	4	55	2	34515499
Pubmed	Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex.	TYRO3 CAPN3	1.47e-05	4	55	2	9846490
Pubmed	A combination of SILAC and nucleotide acyl phosphate labelling reveals unexpected targets of the Rsk inhibitor BI-D1870.	MST1 MST1L	1.47e-05	4	55	2	27919044
Pubmed	Mst1/2 Kinases Modulate Glucose Uptake for Osteoblast Differentiation and Bone Formation.	MST1 MST1L	1.47e-05	4	55	2	29474739
Pubmed	mTORC2 regulates cardiac response to stress by inhibiting MST1.	MST1 MST1L	1.47e-05	4	55	2	25843706
Pubmed	The Mst1 and Mst2 kinases control activation of rho family GTPases and thymic egress of mature thymocytes.	MST1 MST1L	1.47e-05	4	55	2	22412158
Pubmed	Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide.	MST1 MST1L	1.47e-05	4	55	2	14734766
Pubmed	Thioredoxin-1 functions as a molecular switch regulating the oxidative stress-induced activation of MST1.	MST1 MST1L	1.47e-05	4	55	2	23085515
Pubmed	Functional role of Mst1/Mst2 in embryonic stem cell differentiation.	MST1 MST1L	1.47e-05	4	55	2	24224013
Pubmed	Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.	MST1 MST1L	2.45e-05	5	55	2	20080689
Pubmed	Mst1 regulates integrin-dependent thymocyte trafficking and antigen recognition in the thymus.	MST1 MST1L	2.45e-05	5	55	2	23033074
Pubmed	Assignment of the gene coding for hepatocyte growth factor-like protein to mouse chromosome 9.	MST1 MST1L	2.45e-05	5	55	2	1354648
Pubmed	The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naïve T cells.	MST1 MST1L	2.45e-05	5	55	2	19073936
Pubmed	Mst1 inhibits Sirt3 expression and contributes to diabetic cardiomyopathy through inhibiting Parkin-dependent mitophagy.	MST1 MST1L	2.45e-05	5	55	2	29674007
Pubmed	Mst1-Deficiency Induces Hyperactivation of Monocyte-Derived Dendritic Cells via Akt1/c-myc Pathway.	MST1 MST1L	2.45e-05	5	55	2	31572367
Pubmed	Tubule-Specific Mst1/2 Deficiency Induces CKD via YAP and Non-YAP Mechanisms.	MST1 MST1L	2.45e-05	5	55	2	32253273
Pubmed	Mst1 attenuates myocardial ischemia/reperfusion injury following heterotopic heart transplantation in mice through regulating Keap1/Nrf2 axis.	MST1 MST1L	2.45e-05	5	55	2	36646002
Pubmed	A single transcription factor is sufficient to induce and maintain secretory cell architecture.	MST1 MST1L	2.45e-05	5	55	2	28174210
Pubmed	A critical role for NF2 and the Hippo pathway in branching morphogenesis.	MST1 MST1L RET	2.57e-05	36	55	3	27480037
Pubmed	BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse.	BTNL3 NOTCH4	3.67e-05	6	55	2	10803852
Pubmed	Daxx mediates activation-induced cell death in microglia by triggering MST1 signalling.	MST1 MST1L	3.67e-05	6	55	2	21572393
Pubmed	Mst1-FoxO signaling protects Naïve T lymphocytes from cellular oxidative stress in mice.	MST1 MST1L	3.67e-05	6	55	2	19956688
Pubmed	Netrin1 deficiency activates MST1 via UNC5B receptor, promoting dopaminergic apoptosis in Parkinson's disease.	MST1 MST1L	3.67e-05	6	55	2	32929029
Pubmed	cDNA cloning and chromosomal mapping of the mouse type VII collagen gene (Col7a1): evidence for rapid evolutionary divergence of the gene.	MST1 MST1L	3.67e-05	6	55	2	8325648
Pubmed	Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL.	MST1 MST1L	3.67e-05	6	55	2	24813943
Pubmed	MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.	MST1 MST1L	5.13e-05	7	55	2	27701149
Pubmed	MOBKL1A/MOBKL1B phosphorylation by MST1 and MST2 inhibits cell proliferation.	MST1 MST1L	5.13e-05	7	55	2	18328708
Pubmed	Genome-wide association scan in north Indians reveals three novel HLA-independent risk loci for ulcerative colitis.	CFB NOTCH4	5.13e-05	7	55	2	24837172
Pubmed	Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.	CFB NOTCH4	6.83e-05	8	55	2	22694956
Pubmed	Mechanisms of mannose-binding lectin-associated serine proteases-1/3 activation of the alternative pathway of complement.	FCN2 CFB	1.10e-04	10	55	2	21943708
Pubmed	Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass.	MST1 MST1L	1.10e-04	10	55	2	26378466
Pubmed	Expression screening of a yeast artificial chromosome contig refines the location of the mouse H3a minor histocompatibility antigen gene.	TYRO3 CAPN3	1.10e-04	10	55	2	9670959
Pubmed	A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain.	MST1 NRXN2 MST1L	1.14e-04	59	55	3	15010206
Cytoband	9q34.3	FCN2 INPP5E LCN8	2.88e-04	106	55	3	9q34.3
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SMYD1 SUV39H1	1.96e-03	34	35	2	487
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	TYRO3 RET	2.71e-03	40	35	2	321
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	CSMD3 CFB	5.44e-03	57	35	2	1179
ToppCell	Control-Control-Lymphocyte-T/NK-NK_activated\|Control / Disease, condition lineage and cell class	MEGF8 NRXN2 FGFBP2 TNKS1BP1 HERC1	4.57e-06	198	55	5	76d5fe4e5bbe6c73a6ca409b80b5c3924e07cab7
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-CD4_CTL\|Multiple_Sclerosis / Disease, Lineage and Cell Type	NRN1L STBD1 FGFBP2 PAGE5	4.79e-05	162	55	4	d53de64df2511eddba79f899fc3f48b1b059923f
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B0\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	VIPR1 TMPRSS9 PACSIN1 LTBP1	5.14e-05	165	55	4	ebd668e87e5961a124d1d6fc25d1f03e4af05cd4
ToppCell	356C-Fibroblasts-Fibroblast-H-\|356C / Donor, Lineage, Cell class and subclass (all cells)	TYRO3 LTBP1 RET CFB	5.51e-05	168	55	4	b5d74500bdac0d680ce7eb7afa0b867b8d85e6a4
ToppCell	356C-Fibroblasts-Fibroblast-H\|356C / Donor, Lineage, Cell class and subclass (all cells)	TYRO3 LTBP1 RET CFB	5.51e-05	168	55	4	838ce47d4958ba12047882f97925eddd02f081c7
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|368C / Donor, Lineage, Cell class and subclass (all cells)	NRN1L THBS4 LTBP1 CRISPLD1	5.64e-05	169	55	4	1d5ce2c97f7ef7bdc9f861938077a9aa31d84db6
ToppCell	3'-Broncho-tracheal-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCN2 RFTN2 CRISPLD1 NOTCH4	5.64e-05	169	55	4	0d8b681404e18f3061d84425fb5f7d84e8e2b8d7
ToppCell	3'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TMPRSS9 NRXN2 FGFBP2 LTBP1	5.64e-05	169	55	4	2456b3e7776e8a2214972be1b4d66a3ca5480ae0
ToppCell	368C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	NRN1L THBS4 LTBP1 CRISPLD1	5.64e-05	169	55	4	58098f8801ca941aeddafb47e88ab0df8b9edb57
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_G2M\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	PACSIN1 SUV39H1 CAPN3 DGKA	5.77e-05	170	55	4	2d5e56eee0c3ce75a9641cc14dee0e0807141c32
ToppCell	COVID-pDC\|COVID / Condition, Cell_class and T cell subcluster	PACSIN1 IRF7 RET NOTCH4	6.04e-05	172	55	4	3ecbb000495dde32f6153ef6bdea9c8802ff3985
ToppCell	COVID-pDC-\|COVID / Condition, Cell_class and T cell subcluster	PACSIN1 IRF7 RET NOTCH4	6.04e-05	172	55	4	a7827faa1afab51fdaf0cb1a2babcd2e00d411e5
ToppCell	COPD-Myeloid-pDC\|World / Disease state, Lineage and Cell class	PACSIN1 IRF7 RET NOTCH4	6.32e-05	174	55	4	be8227398300711ccda5ecc41ad34064bb246b19
ToppCell	RSV-Healthy-1\|Healthy / Virus stimulation, Condition and Cluster	VIPR1 MEGF8 FGFBP2 IRF7	6.46e-05	175	55	4	ff3a27f512a3a710ebc863b7b75cce8167d5440b
ToppCell	RSV-Healthy-1\|RSV / Virus stimulation, Condition and Cluster	VIPR1 MEGF8 FGFBP2 IRF7	6.46e-05	175	55	4	ca52b99b03535a5b3a2751d6981708dc5b255b91
ToppCell	IPF-Myeloid-pDC\|World / Disease state, Lineage and Cell class	PACSIN1 IRF7 RET NOTCH4	6.46e-05	175	55	4	a06785a4ded01adfd29ca4c20f7759eccbe274cb
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)\|343B / Donor, Lineage, Cell class and subclass (all cells)	THBS4 STBD1 NRXN2 LTBP1	6.75e-05	177	55	4	e55d21d4d61a069b9bbe0e7595fbfb7cfbacfd87
ToppCell	343B-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	THBS4 STBD1 NRXN2 LTBP1	6.75e-05	177	55	4	43ba6f12c2fb32698a420bf799d46ac1b558f146
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR1 SLCO3A1 TNKS1BP1 TRIM68	6.75e-05	177	55	4	7c3d46ebd7e8726be6871aa9763e281fc0ec6ac8
ToppCell	facs-Heart-RV-18m-Mesenchymal-valve_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR1 SLCO3A1 TNKS1BP1 TRIM68	6.75e-05	177	55	4	e7b1f3092e6b8d0d580f82648035f5ad12be6961
ToppCell	COPD-Myeloid-pDC\|COPD / Disease state, Lineage and Cell class	PACSIN1 IRF7 RET NOTCH4	6.75e-05	177	55	4	415aa023195a7f961c09529f65cdcc7bb90eaf5d
ToppCell	IPF-Myeloid-pDC\|IPF / Disease state, Lineage and Cell class	PACSIN1 IRF7 RET NOTCH4	6.90e-05	178	55	4	8d9e28492e1f157bac3308aa947fd864ca16d277
ToppCell	COPD-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	PACSIN1 IRF7 RET NOTCH4	7.05e-05	179	55	4	29b058c5e33fda9f0d738c074bdb67ff16b9b6d5
ToppCell	IPF-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	PACSIN1 IRF7 RET NOTCH4	7.21e-05	180	55	4	0f8567aa835d4e3a52f6631ae15216eca18a030c
ToppCell	3'_v3-Lung-Myeloid_Dendritic-pDC\|Lung / Manually curated celltypes from each tissue	PACSIN1 IRF7 RET NOTCH4	7.36e-05	181	55	4	3d7f089fb434fbc989f1fa159e22133ae00b2487
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VIPR1 PACSIN1 CAPN3 DGKA	7.52e-05	182	55	4	01ae44b465e509b0aa75ccf61bd9bc0a89d6758c
ToppCell	myeloid-Dendritic_cell-Plasmacytoid_dendritic_cell\|World / Lineage, cell class and subclass	PACSIN1 IRF7 RET NOTCH4	7.85e-05	184	55	4	11619778bc773ecd1a9867330be04deaf324f31e
ToppCell	droplet-Spleen-SPLEEN-1m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR1 PACSIN1 DGKA SLCO3A1	8.01e-05	185	55	4	39f2b7a35253968f6d744c10ece1478a05cf24da
ToppCell	ILEUM-inflamed-(3)_MNP-(3)_pDC\|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PACSIN1 IRF7 RET NOTCH4	8.01e-05	185	55	4	308a98f111895071d8772bc010554471cc12fab2
ToppCell	IIH-NK\|IIH / Condition, Cell_class and T cell subcluster	IL12RB2 PACSIN1 FGFBP2 SCART1	8.18e-05	186	55	4	cab1249b849013cf0334f25ee8d840f0521f4eb8
ToppCell	IIH-NK-\|IIH / Condition, Cell_class and T cell subcluster	IL12RB2 PACSIN1 FGFBP2 SCART1	8.18e-05	186	55	4	2c90b45c8ccfd86bbf6840dba7f0d7f08b5ea914
ToppCell	droplet-Kidney-nan-18m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VIPR1 CRISPLD1 NOTCH4 JPH3	8.35e-05	187	55	4	e93cad16a087d1443cbf4e1690dc1b35d7a84c41
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TNKS1BP1 ARMCX4 CRISPLD1 NOTCH4	8.52e-05	188	55	4	5bc1537e079c7435196c163bff5f639ea392a33a
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NRXN2 SLCO3A1 RET JPH3	8.52e-05	188	55	4	bd091503f580dedab40e0996273101285d24b586
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Lobular_Carcinoma-6\|TCGA-Breast / Sample_Type by Project: Shred V9	THBS4 SHROOM1 NRXN2 NOTCH4	8.52e-05	188	55	4	c90669b51e1902fe7726555290c91c92a911df83
ToppCell	3'_v3-lymph-node_spleen-Myeloid_Dendritic-pDC\|lymph-node_spleen / Manually curated celltypes from each tissue	PACSIN1 IRF7 RET NOTCH4	8.70e-05	189	55	4	6c2ace61a7d62bcf7e76b73e2da8b722d03e713b
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 LTBP1 LOXL3 RET	8.70e-05	189	55	4	1db5dd1ef2a65251af2d5696622d1dd9c4ae2b55
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 LTBP1 LOXL3 RET	8.70e-05	189	55	4	bfb1c183a8a2752a2368b74150e66181c6a9da48
ToppCell	368C-Lymphocytic-NK_cells-Proliferating_NK_cell\|368C / Donor, Lineage, Cell class and subclass (all cells)	IL12RB2 FGFBP2 SUV39H1 TSEN54	8.70e-05	189	55	4	31d34bc75d4457fca197e1766922e987dbd5f8a9
ToppCell	facs-Thymus-Epithelium-3m-Mesenchymal-fibroblast\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	THBS4 LTBP1 LOXL3 RET	8.70e-05	189	55	4	14833feea8f80744a06ece73f813eaeff8c4dd61
ToppCell	(011)_pDC\|World / immune cells in Peripheral Blood (logTPM normalization)	PACSIN1 IRF7 RET NOTCH4	9.06e-05	191	55	4	d82ac4f6d9863734e09bf3cb71c1354a49b66b4f
ToppCell	background-Endothelial_cells\|background / Sample and Cell Type and Tumor Cluster (all cells)	FCN2 SLCO3A1 HERC1 NOTCH4	1.00e-04	196	55	4	e6fb0bfab1779ec64a8c35d01519eaafbf62e977
ToppCell	IPF-Endothelial-VE_Capillary_B\|Endothelial / Disease state, Lineage and Cell class	VIPR1 LSS LTBP1 NOTCH4	1.00e-04	196	55	4	8f0f72ead06abe02b575e443552eacc2151077ef
ToppCell	(5)_Fibroblast-J_(Lipofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	TYRO3 NRXN2 CRISPLD1 CFB	1.00e-04	196	55	4	afa29399decd17fda7d63add5039ff778627ccc2
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THBS4 LTBP1 CSMD3 CRISPLD1	1.02e-04	197	55	4	2cb1f557ce1400398975de94638126b4522567f3
ToppCell	distal-1-Hematologic-Plasmacytoid_Dendritic\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMPRSS9 PACSIN1 IRF7 RET	1.02e-04	197	55	4	166d47359df9279ea8c3946f10bd3d4b88c95857
ToppCell	mild-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	PACSIN1 BRD7 DGKA IRF7	1.02e-04	197	55	4	07a1f59c83b748825e0708cd1cc7b63a2cb856cc
ToppCell	Tracheal-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	THBS4 FGFBP2 LTBP1 CRISPLD1	1.04e-04	198	55	4	7a0c4dbc8c99968d42af00a718f4fedc544599ec
ToppCell	distal-2-Hematologic-Plasmacytoid_Dendritic\|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	TMPRSS9 PACSIN1 IRF7 RET	1.06e-04	199	55	4	78796b05d28b35e7361b6271d4a3858faa39c45c
ToppCell	Parenchymal-10x5prime-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	VIPR1 SHROOM1 LTBP1 NOTCH4	1.08e-04	200	55	4	ac6b8bc9998d303f788511b8f111e682ea9f3df8
ToppCell	(54)_pDC\|World / shred on Cell_type and subtype	PACSIN1 IRF7 RET NOTCH4	1.15e-04	203	55	4	b8ba3e51770ff7b45cd02472f3e63aa4d5816f6f
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.C1ql3_(Hippocampus_Excitatory_Neuron)-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	VIPR1 IL12RB2 CAPN3	2.35e-04	97	55	3	1da964954a95c497ac4a24df1ea3575df5747025
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	VIPR1 IL12RB2 CAPN3	2.35e-04	97	55	3	dd188763ba02337e4f25d56766eda886cffa810d
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	VIPR1 IL12RB2 CAPN3	2.35e-04	97	55	3	a0242258aad0766450ff52fe28278cbb2b8d63a0
ToppCell	Substantia_nigra-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1-Excitatory_Neuron.Slc17a7.C1ql3_(Hippocampus_Excitatory_Neuron)\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	VIPR1 IL12RB2 CAPN3	2.35e-04	97	55	3	98a31b9bf0adcad1cb1d803bf7a23d49b4e1f2d5
ToppCell	COVID-19_Mild-Lymphoid_T/NK-dn_T\|COVID-19_Mild / Disease group, lineage and cell class	PACSIN1 SMYD1 DGKA	4.07e-04	117	55	3	9d417dd137c27f8fe9e57842cd5515fdc2f2dc06
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-dn_T\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PACSIN1 SMYD1 DGKA	4.07e-04	117	55	3	e74dd01ccb6cc630759146655fccec359f725b1d
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-dn_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PACSIN1 SMYD1 DGKA	4.07e-04	117	55	3	3c67e8a184b5a8302cba584e5ee97006f6cd267f
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-dn_T-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PACSIN1 SMYD1 DGKA	4.18e-04	118	55	3	d95344ef24a1a838232186c02725f556c5fd51ac
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	DNAH12 PACSIN1 JPH3	4.18e-04	118	55	3	bc65345ee8e59fbda60f345696192376cdbf54b8
ToppCell	PBMC-Mild-Lymphocyte-T/NK-Other_T-dn_T\|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)	PACSIN1 SMYD1 DGKA	4.18e-04	118	55	3	c234ea1969726356ee47d9364b716044cfbd125a
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-8\|TCGA-Kidney / Sample_Type by Project: Shred V9	PACSIN1 LCN8 PKD1L2	4.72e-04	123	55	3	967f20fcb27c9989de93f4183038334105910175
ToppCell	LPS-antiTNF-Myeloid-Dendritic_cells-pDC\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PACSIN1 SMYD1 IRF7	5.42e-04	129	55	3	454bae525f6db3d0dd6347d2a2c3ea9dda9cd212
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_T_CD4-Tfh\|GI_small-bowel / Manually curated celltypes from each tissue	DNAH12 LTBP1 ARMCX4	6.05e-04	134	55	3	bf94ce5edde8912a27010e229c313d8102d6de62
ToppCell	LPS_only-Myeloid-Dendritic_cells-pDC\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PACSIN1 SMYD1 IRF7	6.18e-04	135	55	3	0afe232aa1a1e6c37a5b3183b67d7fa07e0ea791
ToppCell	Control-Fibroblasts-Mesothelial_FB\|Control / group, cell type (main and fine annotations)	ADGRG2 LTBP1 RET	6.73e-04	139	55	3	e769beb031b262dd92c9605b07dbf3c29fb82520
ToppCell	3'_v3-blood-Lymphocytic_Invariant-Inducer-like-MAIT\|blood / Manually curated celltypes from each tissue	IL12RB2 SCART1 CSMD3	7.16e-04	142	55	3	1175d4390d204ffa3a2d2fe24486f85d3b639b72
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_2-AT1_Progenitor\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NRXN2 CXCL17 IRF7	7.61e-04	145	55	3	186b8bd8ac2d5c66cc29fdc2dd6751eddce3e8b8
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ATL2 CSMD3 TBL3	7.76e-04	146	55	3	ec1f793409d1a81c0f9323eb3c82ffe01dae0e44
ToppCell	Club_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	TMPRSS9 CXCL17 RET	7.92e-04	147	55	3	5a824c89e4d045af465d7333275f8191fb29b041
ToppCell	facs-Marrow-B-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 PACSIN1 LCN8	7.92e-04	147	55	3	9d7e965fe61bd7b31e09c4b2129a5a98c36f4811
ToppCell	facs-Marrow-B-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NRXN2 PACSIN1 LCN8	7.92e-04	147	55	3	38552953ff65a0fc20bee6ef57dc5885306ad18b
ToppCell	frontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADGRG2 LTBP1 CRISPLD1	8.07e-04	148	55	3	5e738522d4ad35e08bc4ff8c41b7bea38ec6ef95
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NRXN2 RRP9 FGFBP2	8.07e-04	148	55	3	065177aaa63c0441d312260b43ecdac78c84ad03
ToppCell	3'_v3-blood-Lymphocytic_Invariant-Inducer-like\|blood / Manually curated celltypes from each tissue	IL12RB2 RET CSMD3	8.23e-04	149	55	3	75422e1a22736375e9ef439db0b2a5efa3f653a3
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	NPHP1 FGFBP2 ZNF343	8.23e-04	149	55	3	68661c8facfb638560bb2e2c20d509941286dacb
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c10-MKI67-GZMK\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	FGFBP2 SUV39H1 TBL3	8.55e-04	151	55	3	c1461d0dd622a081187eba77f454d2663df2732e
ToppCell	Int-URO-Other\|Int-URO / Disease, Lineage and Cell Type	NPHP1 IRF7 CFB	8.55e-04	151	55	3	ea5f25842e621be41a6491c9959d419d9cc7ebd6
ToppCell	Int-URO-Other-RBC\|Int-URO / Disease, Lineage and Cell Type	NPHP1 IRF7 CFB	8.55e-04	151	55	3	0344d482f1c55c9eaa15beb8d6bac1c6cdca21b3
ToppCell	10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-CD8_EM-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	IL12RB2 ADGRG2 DGKA	8.55e-04	151	55	3	e1ffd99001b6a5b795f3367882a9355955c0e569
ToppCell	COVID-19_Severe-CD8+_T_naive\|COVID-19_Severe / disease group, cell group and cell class	VIPR1 DGKA PAGE5	8.72e-04	152	55	3	e6dbf20504c4fb73d1084b587e040855335b8959
ToppCell	368C-Fibroblasts-Fibroblast-H-\|368C / Donor, Lineage, Cell class and subclass (all cells)	STBD1 NRXN2 CFB	8.72e-04	152	55	3	dbfb4d4de36ef9f5c7da1950baa915b12788685e
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PACSIN1 BRD7 DGKA	8.72e-04	152	55	3	405d19b290232bb3e564d61c0cff0cfdd247bdff
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PACSIN1 BRD7 DGKA	8.72e-04	152	55	3	06fa7d8acc8f56de00af9bee17884595b300410e
ToppCell	primary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Ntn1_Npy2r\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	ADGRG2 LTBP1 CRISPLD1	8.72e-04	152	55	3	8ff5a178a8f3550d89a003c0858820aab3773386
ToppCell	368C-Fibroblasts-Fibroblast-H\|368C / Donor, Lineage, Cell class and subclass (all cells)	STBD1 NRXN2 CFB	8.72e-04	152	55	3	9f3682da00fd627e80aa820ecc6f5fed23b9738a
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	PACSIN1 BRD7 DGKA	8.89e-04	153	55	3	b101cb1bce5db785dab46b6c4f7be9c3efe48b0e
ToppCell	Influenza_Severe-CD4+_CTL\|World / Disease group and Cell class	CRYBG2 DNAH12 FGFBP2	8.89e-04	153	55	3	0c6c2c6dbc81badd886f125f4e5ba0fb7d52101c
ToppCell	390C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0.5\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	MEGF8 FGFBP2 CFB	8.89e-04	153	55	3	e7d20c88466ff81db613869cf7a6a4bb95fd6c2f
ToppCell	PBMC-Severe-Lymphocyte-T/NK-Other_T-dn_T-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PACSIN1 BRD7 DGKA	8.89e-04	153	55	3	487388082bb596809ba1caf9197626b6814792ab
ToppCell	Ionocyte\|World / shred by cell class for nasal brushing	TMPRSS9 THBS4 RET	9.06e-04	154	55	3	6b78fb0c96fc7b5e901c39b3424f4aa8d0a6b9cf
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BTNL3 CXCL17 NOTCH4	9.06e-04	154	55	3	e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell	E18.5-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IL12RB2 CAPN3 PKD1L2	9.23e-04	155	55	3	d8e9f355ce933f6383c3d1e35ff55235a95c7fcd
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_B0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TMPRSS9 PACSIN1 LTBP1	9.23e-04	155	55	3	a16e3a72badafa78a3efc4f4ab62396f0ce99d1e
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	MST1 IL12RB2 CRYBG2	9.40e-04	156	55	3	84f01419d8c116714e8c8c857c4d153a755b7867
ToppCell	COVID-19_Severe-Lymphoid_T/NK-dn_T\|COVID-19_Severe / Disease group, lineage and cell class	PACSIN1 BRD7 DGKA	9.40e-04	156	55	3	83f25683e0f55472b56f915ee176fc05efc33a31
ToppCell	368C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	BTNL3 ZNF343 NOTCH4	9.40e-04	156	55	3	4877aabf647238c0279e497345b6a6d5ee07ef9c
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	MST1 IL12RB2 CRYBG2	9.40e-04	156	55	3	2285be9746d0d0f62a488b9c64fa67a834758dd7
ToppCell	368C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	BTNL3 ZNF343 NOTCH4	9.40e-04	156	55	3	1d681fa17e62815f5d5f90c86be3c248b38e011b
ToppCell	PBMC-Mild-cDC_6\|Mild / Compartment, Disease Groups and Clusters	THBS4 SHROOM1 LTBP1	9.40e-04	156	55	3	3db686849844120b3e376599929d11ad06f0d577
Computational	Metal / Ca ion binding.	MST1 THBS4 DGKA LTBP1 RET	4.14e-05	133	32	5	MODULE_324
Disease	inflammatory bowel disease (implicated_via_orthology)	MST1 MST1L KLKB1	1.03e-05	25	50	3	DOID:0050589 (implicated_via_orthology)
Disease	apolipoprotein A-IV measurement	SHROOM1 KLKB1	2.80e-05	5	50	2	EFO_0007848
Disease	Familial aplasia of the vermis	NPHP1 INPP5E	5.24e-04	20	50	2	cv:C0431399
Disease	sorbitol measurement	DHRS4-AS1 RET	6.96e-04	23	50	2	EFO_0010533
Disease	chronic hepatitis B virus infection	CFB NOTCH4	7.58e-04	24	50	2	EFO_0004239
Disease	L-arginine measurement	ADGRG2 KLKB1	9.61e-04	27	50	2	EFO_0006524
Disease	glycine measurement	CAPN3 PKD1L2 KLKB1	1.64e-03	137	50	3	EFO_0009767

Protein segments in the cluster

Peptide	Gene	Start	Entry
VGWYVGVCRDDVDRG	BTNL3	351	Q6UXE8
GTSEIICLGGGRRVW	CSMD3	1216	Q7Z407
DTSQSGEDGGCWQRE	BRD7	261	Q9NPI1
GEDGGCWQREREDSG	BRD7	266	Q9NPI1
RGGWSDNGCSVKDRR	ADGRG2	581	Q8IZP9
GRGSWADAREQVVGD	ARMCX4	1471	Q5H9R4
VRHGSDENCRSWNEG	RFTN2	186	Q52LD8
QRRTCQEGGSWSGTE	CFB	201	P00751
GRVEIQRAGEWGTIC	LOXL3	56	P58215
GTEQSVTECASRGWG	LOXL3	116	P58215
IGVQEGCSDRREWET	INPP5E	336	Q9NRR6
GAVDRTESGRECQRW	MST1L	171	Q2TV78
ENRGNEGTCVGVSRW	HERC1	2081	Q15751
GEQGTVACTWERGRD	IL12RB2	136	Q99665
CIGGFWREVGVASDQ	LCN8	31	Q6JVE9
TEGFRGWNGQCLDVD	LTBP1	1026	Q14766
DGGWGEDFESCEERR	LSS	626	P48449
REGWNRFICDCIGTG	NRXN2	706	Q9P2S2
GQGAGEVWLRVDCRN	FGFBP2	51	Q9BYJ0
DSRILVCGGDGTVGW	DGKA	426	P23743
WSIGGSCDTDGRRVF	DNAH12	1781	Q6ZR08
QARCRGEQISGTVGW	MEGF8	646	Q7Z7M0
RELCWREGPGTDQTE	IRF7	126	Q92985
GRTFRDAQSWCEGQG	PKD1L2	46	Q7Z442
GEEDEQGWCRGRLDS	PACSIN1	416	Q9BY11
ESENRVSEGRWGRGC	DHRS4-AS1	46	Q9P1J3
DTDGGGWTVFQRRVD	FCN2	136	Q15485
IDNDGGWVDITRQGR	CRISPLD1	346	Q9H336
CQGSGREVWGDIVDA	CRYBG2	996	Q8N1P7
GFTWRGGCERETTGI	ATL2	136	Q8NHH9
GGCERETTGIQVWNE	ATL2	141	Q8NHH9
TSWGEGCARREQPGV	KLKB1	596	P03952
GQASRRWLQEGGQEC	CXCL17	36	Q6UXB2
GAVDRTESGRECQRW	MST1	201	P26927
VSVNEGRWVRGCSAG	CAPN3	431	P20807
IRNSTGERGELSCGW	NPHP1	476	O15259
AGNRGWAGTREEVRD	PAGE5	6	Q96GU1
GRGGELETICRSWND	NRN1L	61	Q496H8
AREGVGCSWESGRAE	TSEN54	271	Q7Z6J9
EAGEIRWGAEGRDVC	SLCO3A1	136	Q9UIG8
GRQEGWCRDSTTDEQ	RABGGTA	336	Q92696
MWRVEREGTGLTEGC	SMYD1	111	Q8NB12
DDCWQGVNGSVGISR	SHROOM1	451	Q2M3G4
RGGGACLQARTWSVD	NOTCH4	1871	Q99466
CIFRTDDGRGWGVRT	SUV39H1	246	O43463
ERQGDVTCVCGVGWA	THBS4	441	P35443
IQGRNVSRSCTDEGW	VIPR1	96	P32241
VSCWFENAEGQERGG	ZNF343	161	Q6P1L6
EVEVGDRSEWGLGVC	TRIM68	361	Q6AZZ1
VENGGVTRWEECSNR	STBD1	326	O95210
CCVTAGGRDGTVRVW	RRP9	296	O43818
TGGCDGAVRVWDIVR	TBL3	126	Q12788
STREWASRCGIGQEE	TNKS1BP1	786	Q9C0C2
GTRCVITGWGSVREG	TMPRSS9	946	Q7Z410
SRCDGRVEVSLDGVW	SCART1	441	Q4G0T1
CEWRQGDGKGITRNF	RET	541	P07949
DAGRYWCQVEDGGET	TYRO3	111	Q06418
GRAGDCARSSWGEEQ	JPH3	521	Q8WXH2
CARSSWGEEQAGGSR	JPH3	526	Q8WXH2