Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnatural killer cell lectin-like receptor binding

MICA MICB

2.36e-0417272GO:0046703
DomainMHC_I

MICA MICB

3.85e-0421262PF00129
DomainMHC_I_a_a1/a2

MICA MICB

3.85e-0421262IPR001039
Domain-

MICA MICB

5.05e-04242623.30.500.10
DomainMHC_I-like_Ag-recog

MICA MICB

5.05e-0424262IPR011161
DomainMHC_I/II-like_Ag-recog

MICA MICB

1.27e-0338262IPR011162
DomainC1-set

MICA MICB

2.55e-0354262PF07654
DomainIGc1

MICA MICB

2.74e-0356262SM00407
DomainIg_C1-set

MICA MICB

2.94e-0358262IPR003597
PathwayKEGG_MEDICUS_PATHOGEN_KSHV_MIR2_TO_CELL_SURFACE_MOLECULE_ENDOCYTOSIS

MICA MICB

2.57e-056192M47469
Pubmed

PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis.

MICA MICB

5.80e-07227210691930
Pubmed

Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules.

MICA MICB

5.80e-0722729770516
Pubmed

[The polymorphism distributions of MICA and MICB microsatellite in Guangdong Han population].

MICA MICB

5.80e-07227215192843
Pubmed

[The study on the haplotype of MICA and MICB microsatellite locus in Guangzhou Han population].

MICA MICB

5.80e-07227215640005
Pubmed

MICA/B expression is inhibited by unfolded protein response and associated with poor prognosis in human hepatocellular carcinoma.

MICA MICB

5.80e-07227225228093
Pubmed

MICA/B expression in macrophage foam cells infiltrating atherosclerotic plaques.

MICA MICB

5.80e-07227224997223
Pubmed

Association Between Major Histocompatibility Complex Class I Chain-Related Gene Polymorphisms and Susceptibility of Systemic Lupus Erythematosus.

MICA MICB

5.80e-07227229078849
Pubmed

Inhibition of the HDAC/Suv39/G9a pathway restores the expression of DNA damage-dependent major histocompatibility complex class I-related chain A and B in cancer cells.

MICA MICB

5.80e-07227228677817
Pubmed

Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.

MICA MICB

5.80e-07227226902929
Pubmed

Associations between MICA and MICB Genetic Variants, Protein Levels, and Colorectal Cancer: Atherosclerosis Risk in Communities (ARIC).

MICA MICB

5.80e-07227236958849
Pubmed

High frequency of MIC null haplotype (HLA-B48-MICA-del-MICB*0107 N) in the Angaite Amerindian community in Paraguay.

MICA MICB

5.80e-07227212242594
Pubmed

MICA, MICB Polymorphisms and Linkage Disequilibrium with HLA-B in a Chinese Mongolian Population.

MICA MICB

5.80e-07227227028549
Pubmed

Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium.

MICA MICB

5.80e-0722728901601
Pubmed

Structure of MHC class I-like MILL2 reveals heparan-sulfate binding and interdomain flexibility.

MICA MICB

5.80e-07227230337538
Pubmed

Associations of high-resolution-typing-defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients.

MICA MICB

5.80e-07227233835601
Pubmed

Association study of MICA and MICB in Alzheimer's disease.

MICA MICB

5.80e-07227219691640
Pubmed

Impact of MICA-TM, MICB-C1_2_A and C1_4_1 microsatellite polymorphisms on the susceptibility to chronic periodontitis in Germany.

MICA MICB

5.80e-07227221388352
Pubmed

Diversity and characterization of polymorphic 5' promoter haplotypes of MICA and MICB genes.

MICA MICB

5.80e-07227224962621
Pubmed

MICB*002 and MICB*014 protect against rheumatoid arthritis, whereas MICA*009 and MICA*A6 are associated with rheumatoid arthritis in a Hainan Han Chinese population.

MICA MICB

5.80e-07227229665245
Pubmed

High resolution MIC genotyping: design and application to the investigation of inflammatory bowel disease susceptibility.

MICA MICB

5.80e-07227212392511
Pubmed

A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing.

MICA MICB

5.80e-07227218560379
Pubmed

Association of MICA and MICB alleles with symptomatic dengue infection.

MICA MICB

5.80e-07227221762746
Pubmed

In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer.

MICA MICB

5.80e-07227217565371
Pubmed

Conserved amino acids within the adenovirus 2 E3/19K protein differentially affect downregulation of MHC class I and MICA/B proteins.

MICA MICB

5.80e-07227219949079
Pubmed

The alteration of placental-derived soluble MHC class I chain-related protein A and B during pregnancy.

MICA MICB

5.80e-07227221426309
Pubmed

AluyMICB dimorphism within the class I region of the major histocompatibility complex is associated with asthma and airflow obstruction in the Busselton population.

MICA MICB

5.80e-07227216776673
Pubmed

Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB.

MICA MICB

5.80e-07227210359807
Pubmed

The association between MICA/MICB polymorphism and respiratory syncytial virus infection in children.

MICA MICB

5.80e-07227228925058
Pubmed

Major Histocompatibility Complex Class I Chain-Related A and B (MICA and MICB) Gene, Allele, and Haplotype Associations With Dengue Infections in Ethnic Thais.

MICA MICB

5.80e-07227232737971
Pubmed

Expression of major histocompatibility complex class I-related chain A/B (MICA/B) in pancreatic carcinoma.

MICA MICB

5.80e-07227224173243
Pubmed

MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue.

MICA MICB

5.80e-07227228334733
Pubmed

Increased Concentrations of Circulating Soluble MHC Class I-Related Chain A (sMICA) and sMICB and Modulation of Plasma Membrane MICA Expression: Potential Mechanisms and Correlation With Natural Killer Cell Activity in Systemic Lupus Erythematosus.

MICA MICB

5.80e-07227234012432
Pubmed

Hepatitis B surface antigen inhibits MICA and MICB expression via induction of cellular miRNAs in hepatocellular carcinoma cells.

MICA MICB

5.80e-07227223917076
Pubmed

Wide distribution of the MICA-MICB null haplotype in East Asians.

MICA MICB

5.80e-07227211169252
Pubmed

Propionic acid secreted from propionibacteria induces NKG2D ligand expression on human-activated T lymphocytes and cancer cells.

MICA MICB

5.80e-07227219553547
Pubmed

Association of MICA-TM and MICB C1_2_A microsatellite polymorphisms with tumor progression in patients with colorectal cancer.

MICA MICB

5.80e-07227219353249
Pubmed

2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation.

MICA MICB

5.80e-07227222227571
Pubmed

Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabine-induced MICA/B expression.

MICA MICB

5.80e-07227221605422
Pubmed

MIC gene polymorphism and haplotype diversity in Zhuang nationality of Southern China.

MICA MICB

5.80e-07227225167773
Pubmed

A new polymorphic and multicopy MHC gene family related to nonmammalian class I.

MICA MICB

5.80e-0722727927538
Pubmed

Expression and role of MICA and MICB in human hepatocellular carcinomas and their regulation by retinoic acid.

MICA MICB

5.80e-07227212569559
Pubmed

Evasion from NK cell immunity by MHC class I chain-related molecules expressing colon adenocarcinoma.

MICA MICB

5.80e-07227214662896
Pubmed

Broad MICA/B expression in the small bowel mucosa: a link between cellular stress and celiac disease.

MICA MICB

5.80e-07227224058482
Pubmed

Clinical significance of tumor expression of major histocompatibility complex class I-related chains A and B (MICA/B) in gastric cancer patients.

MICA MICB

5.80e-07227226708143
Pubmed

Diversity and characterisation of polymorphic 3' untranslated region haplotypes of MICA and MICB genes.

MICA MICB

5.80e-07227230471210
Pubmed

Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia.

MICA MICB

5.80e-07227212714493
Pubmed

MICA and MICB microsatellite alleles in HLA extended haplotypes.

MICA MICB

5.80e-07227211881819
Pubmed

Alternatively spliced forms of MICA and MICB lacking exon 3 in a human cell line and evidence of presence of similar RNA in human peripheral blood mononuclear cells.

MICA MICB

5.80e-07227212466900
Pubmed

Allelic and interlocus comparison of the PERB11 multigene family in the MHC.

MICA MICB

5.80e-0722728995188
Pubmed

Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition.

MICA MICB

5.80e-07227234482362
Pubmed

Association of MICA and MICB polymorphisms with the susceptibility of leukemia in Korean patients.

MICA MICB

5.80e-07227229895953
Pubmed

Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells.

MICA MICB

5.80e-0722729497295
Pubmed

HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals from the Bulgarian population.

MICA MICB

5.80e-07227235525711
Pubmed

MICB polymorphisms and haplotypes with MICA and HLA alleles in Koreans.

MICA MICB

5.80e-07227221554252
Pubmed

Sodium valproate, a histone deacetylase inhibitor, augments the expression of cell-surface NKG2D ligands, MICA/B, without increasing their soluble forms to enhance susceptibility of human osteosarcoma cells to NK cell-mediated cytotoxicity.

MICA MICB

5.80e-07227221042760
Pubmed

MICB microsatellite polymorphism is associated with ulcerative colitis in Chinese population.

MICA MICB

5.80e-07227216679067
Pubmed

[Expression of MICA/B protein in esophageal cancer and its clinical significance].

MICA MICB

5.80e-07227223291067
Pubmed

Adenovirus E3/19K promotes evasion of NK cell recognition by intracellular sequestration of the NKG2D ligands major histocompatibility complex class I chain-related proteins A and B.

MICA MICB

1.74e-06327218287244
Pubmed

Expression of MICA, MICB and NKG2D in human leukemic myelomonocytic and cervical cancer cells.

MICA MICB

1.74e-06327221477352
Pubmed

MMP9 Promoter Polymorphism (-1562 C/T) Does not Affect the Serum Levels of Soluble MICB and MICA in Breast Cancer.

MICA MICB

1.74e-06327227026046
Pubmed

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells.

MICA MICB

1.74e-06327226071561
Pubmed

Study on the haplotypes of MICA and MICB microsatellite and HLA-B locus in the Guangzhou Han population.

MICA MICB

1.74e-06327215304009
Pubmed

Midkine upregulates MICA/B expression in human gastric cancer cells and decreases natural killer cell cytotoxicity.

MICA MICB

1.74e-06327222415659
Pubmed

Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.

MICA MICB

1.74e-06327216923796
Pubmed

Critical role of MHC class I-related chain A and B expression on IFN-alpha-stimulated dendritic cells in NK cell activation: impairment in chronic hepatitis C virus infection.

MICA MICB

1.74e-06327212538683
Pubmed

Mutual activation of CD4+ T cells and monocytes mediated by NKG2D-MIC interaction requires IFN-gamma production in systemic lupus erythematosus.

MICA MICB

1.74e-06327219200602
Pubmed

Altered microRNA expression after infection with human cytomegalovirus leads to TIMP3 downregulation and increased shedding of metalloprotease substrates, including MICA.

MICA MICB

1.74e-06327224973455
Pubmed

[Expression of NKG2D ligands in multidrug-resistant nasopharyngeal carcinoma cell line CNE2/DDP and their effects on cytotoxicity of natural killer cells].

MICA MICB

1.74e-06327217584663
Pubmed

Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D.

MICA MICB

1.74e-06327217202358
Pubmed

Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation.

MICA MICB

1.74e-06327212384702
Pubmed

Regulation of the expression of MHC class I-related chain A, B (MICA, MICB) via chromatin remodeling and its impact on the susceptibility of leukemic cells to the cytotoxicity of NKG2D-expressing cells.

MICA MICB

1.74e-06327217625602
Pubmed

The prognostic significance of soluble NKG2D ligands in B-cell chronic lymphocytic leukemia.

MICA MICB

1.74e-06327220428196
Pubmed

Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis.

MICA MICB

1.74e-06327218791713
Pubmed

MHC class I-like MILL molecules are beta2-microglobulin-associated, GPI-anchored glycoproteins that do not require TAP for cell surface expression.

MICA MICB

1.74e-06327216920948
Pubmed

Estrogen upregulates MICA/B expression in human non-small cell lung cancer through the regulation of ADAM17.

MICA MICB

1.74e-06327225363527
Pubmed

Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression.

MICA MICB

1.74e-06327221857986
Pubmed

Associations of major histocompatibility complex class I chain-related molecule polymorphisms with Behcet's disease in Caucasian patients.

MICA MICB

1.74e-06327216101830
Pubmed

Immunostimulation by induced expression of NKG2D and its MIC ligands in HTLV-1-associated neurologic disease.

MICA MICB

1.74e-06327216568261
Pubmed

Reconstructing an ancestral mammalian immune supercomplex from a marsupial major histocompatibility complex.

MICA MICB

1.74e-06327216435885
Pubmed

MHC class I chain-related gene B (MICB) is associated with rheumatoid arthritis susceptibility.

MICA MICB

1.74e-06327217003176
Pubmed

The fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B shedding.

MICA MICB

3.48e-06427232968163
Pubmed

Potential role of NKG2D/MHC class I-related chain A interaction in intrathymic maturation of single-positive CD8 T cells.

MICA MICB

3.48e-06427212902493
Pubmed

Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity.

MICA MICB

3.48e-06427225775242
Pubmed

Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17.

MICA MICB

3.48e-06427223526433
Pubmed

The inhibitory effects of synthetic short peptides, mimicking MICA and targeting at NKG2D receptors, on function of NK cells.

MICA MICB

3.48e-06427215652646
Pubmed

Expression of the nonclassical HLA class I and MICA/B molecules in human hepatocellular carcinoma.

MICA MICB

3.48e-06427221744989
Pubmed

HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines.

MICA MICB

3.48e-06427222301547
Pubmed

Genetic influence of the nonclassical major histocompatibility complex class I molecule MICB in multiple sclerosis susceptibility.

MICA MICB

3.48e-06427218588574
Pubmed

A second lineage of mammalian major histocompatibility complex class I genes.

MICA MICB

3.48e-0642728022771
Pubmed

Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate.

CTNND2 ATN1

3.48e-06427210332026
Pubmed

[Expression of NKG2D ligands on dendritic cells at different development stages and its effect on cytotoxicity of NK cells].

MICA MICB

3.48e-06427218394338
Pubmed

Sequencing-based genotyping and association analysis of the MICA and MICB genes in type 1 diabetes.

MICA MICB

3.48e-06427218332098
Pubmed

MICA rather than MICB, TNFA, or HLA-DRB1 is associated with susceptibility to psoriatic arthritis.

MICA MICB

5.80e-06527212022360
Pubmed

[Expression of NKG2D and NKG2A with their ligands MHC-I A/B and HLA-E in acute leukemia patients and its significance].

MICA MICB

5.80e-06527221518478
Pubmed

A family of MHC class I-like genes located in the vicinity of the mouse leukocyte receptor complex.

MICA MICB

8.69e-06627212370446
Pubmed

Interactions of human NKG2D with its ligands MICA, MICB, and homologs of the mouse RAE-1 protein family.

MICA MICB

8.69e-06627211491531
Pubmed

Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

MICA MICB

8.69e-06627210894171
Pubmed

The haplotype block, NFKBIL1-ATP6V1G2-BAT1-MICB-MICA, within the class III-class I boundary region of the human major histocompatibility complex may control susceptibility to hepatitis C virus-associated dilated cardiomyopathy.

MICA MICB

8.69e-06627216101831
Pubmed

ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor.

MICA MICB

1.22e-05727211239445
Pubmed

Genes in a 220-kb region spanning the TNF cluster in human MHC.

MICA MICB

1.22e-0572728824804
InteractionLRFN1 interactions

MICA MAP3K21 CDC25C HDAC7

1.84e-05124264int:LRFN1
InteractionMAGI1 interactions

ATN1 MAP3K21 CDC25C HDAC7

3.59e-05147264int:MAGI1
InteractionGIGYF1 interactions

ATN1 MAP3K21 CDC25C HDAC7

7.39e-05177264int:GIGYF1
InteractionINPP5E interactions

MAP3K21 CDC25C HDAC7

7.90e-0565263int:INPP5E
GeneFamilyC1-set domain containing

MICA MICB

7.01e-0442172591
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#1_top-relative-expression-ranked_100

RARB TP53INP1 FOXF1

1.27e-0536273DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k1_100
DrugPNU-0230031 [267429-39-0]; Down 200; 1uM; PC3; HT_HG-U133A

TNS2 RARB ATN1 SH3TC1 HDAC7

2.96e-061942754291_DN
DrugHydralazine hydrochloride [304-20-1]; Down 200; 20.4uM; PC3; HT_HG-U133A

TNS2 SAMD9 CTNND2 SH3TC1 HDAC7

3.11e-061962753724_DN
DrugPhensuximide [86-34-0]; Up 200; 21.2uM; MCF7; HT_HG-U133A

TNS2 SAMD9 RARB CDC25C HPX

3.27e-061982753521_UP
DrugNovobiocin sodium salt [1476-53-5]; Down 200; 6.4uM; PC3; HT_HG-U133A

SAMD9 ATN1 CDC25C SH3TC1 HDAC7

3.27e-061982754569_DN
DrugATN-2

ATN1 HPX

2.03e-056272CID003081684
DrugClomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; MCF7; HT_HG-U133A

SAMD9 ATN1 SH3TC1 HPX

7.10e-051902746825_UP
DrugAcenocoumarol [152-72-7]; Up 200; 11.4uM; MCF7; HT_HG-U133A

SAMD9 RARB ATN1 HDAC7

8.00e-051962742240_UP
Drughaloperidol; Up 200; 10uM; MCF7; HT_HG-U133A

ATN1 CDC25C HDAC7 HPX

8.16e-051972745563_UP
DrugApomorphine hydrochloride hemihydrate [41372-20-7]; Up 200; 6.4uM; PC3; HT_HG-U133A

CTNND2 ATN1 CDC25C SH3TC1

8.16e-051972746683_UP
DrugZoxazolamine [61-80-3]; Up 200; 23.8uM; MCF7; HT_HG-U133A

SH3TC1 HDAC7 ARIH2 HPX

8.32e-051982745390_UP
Drugnordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A

TNS2 SAMD9 ATN1 HPX

8.32e-051982745583_DN
DrugArtemisinin [63968-64-9]; Up 200; 14.2uM; MCF7; HT_HG-U133A

TNS2 SAMD9 CTNND2 ATN1

8.65e-052002747007_UP
DiseaseGeneralized hypotonia

PIGB ATN1

7.78e-0515262C1858120
DiseaseMHC class I polypeptide-related sequence B measurement

MICA MICB

3.20e-0430262EFO_0008234
DiseaseAnorectal Malformations

CTNND2 FOXF1

5.99e-0441262C3495676
Diseasesusceptibility to common cold measurement

MICA RARB

1.04e-0354262EFO_0008417
Diseaseplatelet crit

ATP13A1 HDAC7 UBALD1 MICB ARIH2

1.29e-03952265EFO_0007985
DiseaseAlzheimer disease, educational attainment

SAMD9 RARB ARIH2

1.31e-03247263EFO_0011015, MONDO_0004975
DiseaseMHC class I polypeptide-related sequence A measurement

MICA MICB

1.64e-0368262EFO_0008233
Diseaseasthma, endometriosis

RARB MICB

1.94e-0374262EFO_0001065, MONDO_0004979

Protein segments in the cluster

PeptideGeneStartEntry
HHECHFPNKAMPSAG

ABCA4

51

P78363
HSMFSQCPPDYHHIH

ATP13A1

661

Q9HD20
GGSSHHAHPYAMSPS

ATN1

521

P54259
PTSHPPHHCAVCMQF

ARIH2

131

O95376
SPSPMSHGHYSMHCL

DLX1

31

P56177
NCFMPSPLHPHYHFS

DNHD1

2576

Q96M86
VHHRPPASEYTMHLG

CTNND2

1176

Q9UQB3
HACPVPAVNGHMTHY

RARB

6

P10826
TCYMEHSGNHSTHPV

MICA

281

Q29983
AATVECMYGHKGPHH

FBXO31

201

Q5XUX0
MRQAFHSHPGTHCPS

ERAL1

266

O75616
TCYMEHSGNHGTHPV

MICB

281

Q29980
HAMDIRCYHSGGPLH

RFESD

51

Q8TAC1
LCEPQSYCPMHHQDH

CDC25C

426

P30307
PPGHHADHSTAMGFC

HDAC7

666

Q8WUI4
CPHSHRTSQYMPASD

HSFX1

396

Q9UBD0
HSVPHLPSNGGHSYM

FOXF1

211

Q12946
NSTHHGPEYMRCSPH

HPX

246

P02790
MMPCHSTPYYSHVHC

PIGB

436

Q92521
HHIPCPEHYNGFCMH

TMEFF2

261

Q9UIK5
NVPYCASSKHRPSHH

MAP3K21

876

Q5TCX8
YHHPGCGGTTLAMHI

SAMD9

736

Q5K651
HPDYHPMTHANDICL

PRSS57

111

Q6UWY2
YSHHGCHGPAITFMT

SH3TC1

796

Q8TE82
HPSMSVYAVHNSCPG

TP53INP1

126

Q96A56
ACGHHHAPMPDYSCL

TNS2

741

Q63HR2
NIPYSHHHHQMMCTP

UBALD1

51

Q8TB05