Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZNF729 ZNF280A ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF219 KCNH8 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF543 ZNF107 ZNF692 ZNF646 ZNF304	7.61e-22	1459	78	37	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZNF729 ZNF280A ZNF793 ZNF34 ZNF136 ZNF836 ZNF320 ZNF219 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF543 ZNF107 ZNF692 ZNF292 ZNF646 ZNF304	3.32e-20	1412	78	35	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF280A ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF219 KCNH8 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF334 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF543 ZNF107 ZNF692 ZNF646 ZNF304	8.70e-19	1244	78	32	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZNF729 ZNF280A ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF219 KCNH8 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF334 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF543 ZNF107 ZNF692 ZNF646 ZNF304	1.64e-18	1271	78	32	GO:0000987
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity, RNA polymerase II-specific	ZNF729 ZNF219 ZBTB17 PATZ1 TRPS1 KLF17 ZNF107 ZNF692	3.53e-05	320	78	8	GO:0001227
GeneOntologyMolecularFunction	DNA-binding transcription repressor activity	ZNF729 ZNF219 ZBTB17 PATZ1 TRPS1 KLF17 ZNF107 ZNF692	4.02e-05	326	78	8	GO:0001217
Domain	ZINC_FINGER_C2H2_2	ZNF729 ZNF280A ZNF462 ZNF793 ZNF567 ZNF34 BNC2 ZNF136 ZNF137P ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 JAZF1 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF385A ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	3.64e-39	775	82	44	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF729 ZNF280A ZNF462 ZNF793 ZNF567 ZNF34 BNC2 ZNF136 ZNF137P ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 JAZF1 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF385A ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	4.08e-39	777	82	44	PS00028
Domain	Znf_C2H2	ZNF729 ZNF280A ZNF462 ZNF793 ZNF567 ZNF34 BNC2 ZNF136 ZNF137P ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 JAZF1 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF385A ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	1.91e-38	805	82	44	IPR007087
Domain	ZnF_C2H2	ZNF729 ZNF280A ZNF462 ZNF793 ZNF567 ZNF34 BNC2 ZNF136 ZNF137P ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 JAZF1 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF385A ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	2.24e-38	808	82	44	SM00355
Domain	zf-C2H2	ZNF729 ZNF462 ZNF793 ZNF567 ZNF34 BNC2 ZNF136 ZNF137P ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 JAZF1 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	7.09e-37	693	82	41	PF00096
Domain	Znf_C2H2-like	ZNF729 ZNF280A ZNF462 ZNF793 ZNF567 ZNF34 BNC2 ZNF136 ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 JAZF1 ZNF534 ZNF264 ZNF766 KLF17 ZNF619 ZNF385A ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	7.98e-36	796	82	42	IPR015880
Domain	-	ZNF729 ZNF280A ZNF462 ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 JAZF1 ZNF534 ZNF264 ZNF766 KLF17 ZNF619 ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	2.22e-34	679	82	39	3.30.160.60
Domain	Znf_C2H2/integrase_DNA-bd	ZNF729 ZNF280A ZNF462 ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 JAZF1 ZNF534 ZNF264 ZNF766 KLF17 ZNF619 ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	5.15e-34	694	82	39	IPR013087
Domain	KRAB	ZNF729 ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF613 ZNF577 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 ZNF534 ZNF264 ZNF766 ZNF543 ZNF282 ZNF304	1.41e-23	358	82	25	PS50805
Domain	KRAB	ZNF729 ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF613 ZNF577 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 ZNF534 ZNF264 ZNF766 ZNF543 ZNF282 ZNF304	1.41e-23	358	82	25	PF01352
Domain	KRAB	ZNF729 ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF613 ZNF577 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 ZNF534 ZNF264 ZNF766 ZNF543 ZNF282 ZNF304	2.98e-23	369	82	25	SM00349
Domain	KRAB	ZNF729 ZNF793 ZNF567 ZNF34 ZNF136 ZNF836 ZNF320 ZNF613 ZNF577 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 ZNF534 ZNF264 ZNF766 ZNF543 ZNF282 ZNF304	3.19e-23	370	82	25	IPR001909
Domain	zf-C2H2_6	ZNF729 ZNF567 ZNF136 ZNF836 ZNF320 ZNF613 ZNF473 ZNF556 ZNF334 ZNF532 PATZ1 ZNF549 ZFP30 ZNF735 ZNF283 ZNF805 ZNF766 ZNF619 ZNF543 ZNF107 ZNF282 ZNF646	9.01e-21	314	82	22	PF13912
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	ZNF729 ZNF793 ZNF567 ZNF34 ZNF136 ZNF320 BRIP1 ZNF613 ZNF577 ZNF473 ZNF556 ZNF334 ZNF337 ZNF559 ZNF549 ZFP30 ZNF735 ZNF264 ZNF619 ZNF385A ZNF543 TTC5 ZNF692 ZNF282 RHNO1 ZNF304	1.88e-12	1387	56	26	M734
Pathway	REACTOME_GENERIC_TRANSCRIPTION_PATHWAY	ZNF729 ZNF136 ZNF836 BRIP1 ZNF473 ZFP30 ZNF385A TTC5 ZNF107 ZNF282 RHNO1	1.83e-04	768	56	11	MM14851
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	ZNF729 ZNF462 BNC2 ZNF836 ZNF219 ZBTB17 ZNF473 ZNF334 PATZ1 TRPS1 JAZF1 KLF17 ZNF385A ZNF282 ZNF292 ZNF646	6.23e-11	808	82	16	20412781
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF567 ZNF34 ZNF136 ZNF320 ZNF805 ZNF264 ZNF766 ZNF543 ZNF107	4.85e-10	181	82	9	37372979
Pubmed	The interactome of KRAB zinc finger proteins reveals the evolutionary history of their functional diversification.	ZNF793 ZNF136 ZNF577 ZNF282	2.03e-07	22	82	4	31403225
Pubmed	Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.	CSNK1D CSNK1E	5.49e-06	2	82	2	19043076
Pubmed	CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation.	CSNK1D CSNK1E	5.49e-06	2	82	2	24424021
Pubmed	Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.	CSNK1D CSNK1E	5.49e-06	2	82	2	9632646
Pubmed	Effects of altered expression and activity levels of CK1δ and ɛ on tumor growth and survival of colorectal cancer patients.	CSNK1D CSNK1E	5.49e-06	2	82	2	25404202
Pubmed	Trps1 is associated with the multidrug resistance of osteosarcoma by regulating MDR1 gene expression.	TRPS1 ABCB1	5.49e-06	2	82	2	24491996
Pubmed	An evaluation of polymorphisms in casein kinase 1 delta and epsilon genes in major psychiatric disorders.	CSNK1D CSNK1E	5.49e-06	2	82	2	22981886
Pubmed	Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders.	ZNF136 ZNF137P ZBTB17	8.39e-06	17	82	3	7557990
Pubmed	ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold.	ZNF729 TRPM6 ZNF836 IRS4 ZNF766 ZNF543 ZNF107 LRRC47	1.16e-05	451	82	8	36168627
Pubmed	Targeting of the circadian clock via CK1δ/ε to improve glucose homeostasis in obesity.	CSNK1D CSNK1E	1.64e-05	3	82	2	27439882
Pubmed	CKIepsilon/delta-dependent phosphorylation is a temperature-insensitive, period-determining process in the mammalian circadian clock.	CSNK1D CSNK1E	1.64e-05	3	82	2	19805222
Pubmed	Centrosomal anchoring of the protein kinase CK1delta mediated by attachment to the large, coiled-coil scaffolding protein CG-NAP/AKAP450.	CSNK1D CSNK1E	1.64e-05	3	82	2	12270714
Pubmed	Casein kinase 1 proteomics reveal prohibitin 2 function in molecular clock.	CSNK1D CSNK1E	1.64e-05	3	82	2	22384121
Pubmed	Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin.	CSNK1D CSNK1E	1.64e-05	3	82	2	25724478
Pubmed	A comparative study of structural and conformational properties of casein kinase-1 isoforms: insights from molecular dynamics and principal component analysis.	CSNK1D CSNK1E	1.64e-05	3	82	2	25665722
Pubmed	CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1.	CSNK1D CSNK1E	1.64e-05	3	82	2	32321936
Pubmed	The Influence of MDR1 Expression Regulated by miR-138 through TRPS1 Signaling Pathway on Multidrug Resistance of Osteosarcoma and Formation of Bacterial Infection Biofilm.	TRPS1 ABCB1	1.64e-05	3	82	2	37571901
Pubmed	Casein kinase 1-epsilon or 1-delta required for Wnt-mediated intestinal stem cell maintenance.	CSNK1D CSNK1E	1.64e-05	3	82	2	28963394
Pubmed	Human Rad17 C-terminal tail is phosphorylated by concerted action of CK1δ/ε and CK2 to promote interaction with the 9-1-1 complex.	CSNK1D CSNK1E	1.64e-05	3	82	2	31353086
Pubmed	Sequence analysis of the cDNA for the human casein kinase I delta (CSNK1D) gene and its chromosomal localization.	CSNK1D CSNK1E	1.64e-05	3	82	2	8786104
Pubmed	CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.	CSNK1D CSNK1E	3.28e-05	4	82	2	29784789
Pubmed	Involvement of casein kinase 1 epsilon/delta (Csnk1e/d) in the pathogenesis of familial Parkinson's disease caused by CHCHD2.	CSNK1D CSNK1E	3.28e-05	4	82	2	37578019
Pubmed	Casein kinase 1 delta functions at the centrosome to mediate Wnt-3a-dependent neurite outgrowth.	CSNK1D CSNK1E	3.28e-05	4	82	2	21422228
Pubmed	The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.	CSNK1D CSNK1E	3.28e-05	4	82	2	20192920
Pubmed	Identification of pathogenic variants in genes related to channelopathy and cardiomyopathy in Korean sudden cardiac arrest survivors.	RYR2 MYBPC3	3.28e-05	4	82	2	28202948
Pubmed	Therapeutic Targeting of Casein Kinase 1δ/ε in an Alzheimer's Disease Mouse Model.	CSNK1D CSNK1E	3.28e-05	4	82	2	31334659
Pubmed	p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs.	CSNK1D CSNK1E	3.28e-05	4	82	2	9349507
Pubmed	Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.	CSNK1D CSNK1E	3.28e-05	4	82	2	7797465
Pubmed	Casein kinase 1 delta (CK1delta) regulates period length of the mouse suprachiasmatic circadian clock in vitro.	CSNK1D CSNK1E	3.28e-05	4	82	2	20421981
Pubmed	Involvement of casein kinase Iepsilon in cytokine-induced granulocytic differentiation.	CSNK1D CSNK1E	3.28e-05	4	82	2	15070676
Pubmed	Phosphorylation of human enhancer filamentation 1 (HEF1) stimulates interaction with Polo-like kinase 1 leading to HEF1 localization to focal adhesions.	CSNK1D CSNK1E	5.47e-05	5	82	2	29191835
Pubmed	Control of intracellular dynamics of mammalian period proteins by casein kinase I epsilon (CKIepsilon) and CKIdelta in cultured cells.	CSNK1D CSNK1E	5.47e-05	5	82	2	11865049
Pubmed	Casein kinase 1 delta regulates the pace of the mammalian circadian clock.	CSNK1D CSNK1E	5.47e-05	5	82	2	19414593
Pubmed	Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.	CSNK1D CSNK1E	5.47e-05	5	82	2	10848614
Pubmed	Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes.	CSNK1D CSNK1E	5.47e-05	5	82	2	29463694
Pubmed	Wnt-3a utilizes a novel low dose and rapid pathway that does not require casein kinase 1-mediated phosphorylation of Dvl to activate beta-catenin.	CSNK1D CSNK1E	5.47e-05	5	82	2	17027228
Pubmed	The CK1δ/ε-AES axis regulates tumorigenesis and metastasis in colorectal cancer.	CSNK1D CSNK1E	5.47e-05	5	82	2	33754069
Pubmed	Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.	CSNK1D CSNK1E	5.47e-05	5	82	2	19948962
Pubmed	Association of genetic variation in genes implicated in the beta-catenin destruction complex with risk of breast cancer.	CSNK1D CSNK1E	8.19e-05	6	82	2	18708403
Pubmed	A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP).	CSNK1D CSNK1E	8.19e-05	6	82	2	20048001
Pubmed	Phosphorylation at Ser244 by CK1 determines nuclear localization and substrate targeting of PKD2.	CSNK1D CSNK1E	8.19e-05	6	82	2	17962809
Pubmed	Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.	CSNK1D CSNK1E	8.19e-05	6	82	2	11818547
Pubmed	Physiological role for casein kinase 1 in glutamatergic synaptic transmission.	CSNK1D CSNK1E	8.19e-05	6	82	2	16014721
Pubmed	BRCT domains of the DNA damage checkpoint proteins TOPBP1/Rad4 display distinct specificities for phosphopeptide ligands.	BRIP1 RHNO1	8.19e-05	6	82	2	30295604
Pubmed	Identification of a novel Wnt5a-CK1ɛ-Dvl2-Plk1-mediated primary cilia disassembly pathway.	CSNK1D CSNK1E	8.19e-05	6	82	2	22609948
Pubmed	High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase.	CSNK1D CSNK1E	8.19e-05	6	82	2	21179498
Pubmed	SPOP-mediated ubiquitination and degradation of PDK1 suppresses AKT kinase activity and oncogenic functions.	CSNK1D CSNK1E	1.14e-04	7	82	2	34353330
Pubmed	Targeted deletion of Sox10 by Wnt1-cre defects neuronal migration and projection in the mouse inner ear.	MYO7A NTF3	1.14e-04	7	82	2	24718611
Pubmed	Modeling of a human circadian mutation yields insights into clock regulation by PER2.	CSNK1D CSNK1E	1.14e-04	7	82	2	17218255
Pubmed	Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway.	CSNK1D CSNK1E	1.14e-04	7	82	2	12000790
Pubmed	SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis.	CSNK1D CSNK1E	1.14e-04	7	82	2	30177679
Pubmed	Tagging genes with cassette-exchange sites.	ZNF462 BNC2 USP5 NAV2 SMARCAD1 ZNF292	1.45e-04	335	82	6	15741177
Pubmed	Casein kinase 1 delta (CK1delta) interacts with the SNARE associated protein snapin.	CSNK1D CSNK1E	1.52e-04	8	82	2	17101137
Pubmed	The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.	CSNK1D CSNK1E	1.52e-04	8	82	2	21930935
Pubmed	Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism.	CSNK1D CSNK1E	1.52e-04	8	82	2	17244647
Pubmed	Dysbindin structural homologue CK1BP is an isoform-selective binding partner of human casein kinase-1.	CSNK1D CSNK1E	1.52e-04	8	82	2	16618118
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ZNF462 ZNF793 KCNH8 ZNF532 NTF3 CSNK1D TRPS1 BTAF1 ZNF385A TEP1 ZNF107 PDZD2	1.88e-04	1489	82	12	28611215
Pubmed	The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development.	SAMHD1 LRRC47	1.96e-04	9	82	2	31186535
Pubmed	SDCBP promotes pancreatic cancer progression by preventing YAP1 from β-TrCP-mediated proteasomal degradation.	CSNK1D CSNK1E	1.96e-04	9	82	2	36828627
Pubmed	Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase.	CSNK1D CSNK1E	1.96e-04	9	82	2	20708156
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	ZNF793 ZNF34 ZNF836 ZNF473 ZNF334 ZNF532 ENPP2 TRPS1 SMARCAD1 ZNF619 ZNF292	2.13e-04	1285	82	11	35914814
Pubmed	Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR.	ZNF729 ZNF836 ZNF107	2.15e-04	49	82	3	9630514
Pubmed	An atlas of combinatorial transcriptional regulation in mouse and man.	ZNF567 ZNF137P ZNF219 BRIP1 ZNF473 ZNF556 ZFP30 TRPS1 ZNF292	2.24e-04	877	82	9	20211142
Pubmed	Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.	CSNK1D CSNK1E	2.44e-04	10	82	2	25500533
Pubmed	Functional analysis of the SRY-KRAB interaction in mouse sex determination.	ZNF729 ZNF107	2.44e-04	10	82	2	18588511
Pubmed	Sry associates with the heterochromatin protein 1 complex by interacting with a KRAB domain protein.	ZNF729 ZNF107	2.98e-04	11	82	2	15469996
Pubmed	Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models.	RYR2 MYBPC3	2.98e-04	11	82	2	27766308
Pubmed	A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.	ZNF462 BNC2 ZNF219 PATZ1	4.04e-04	146	82	4	23892456
Pubmed	Epigenetic gene silencing by the SRY protein is mediated by a KRAB-O protein that recruits the KAP1 co-repressor machinery.	ZNF729 ZNF107	4.21e-04	13	82	2	19850934
Pubmed	Clock genes may influence bipolar disorder susceptibility and dysfunctional circadian rhythm.	CSNK1D CSNK1E	4.21e-04	13	82	2	18228528
Pubmed	A molecular mechanism for circadian clock negative feedback.	CSNK1D CSNK1E	4.21e-04	13	82	2	21680841
Pubmed	Conditional deletion of Atoh1 using Pax2-Cre results in viable mice without differentiated cochlear hair cells that have lost most of the organ of Corti.	MYO7A NTF3	4.91e-04	14	82	2	21146598
Pubmed	Disorganized innervation and neuronal loss in the inner ear of Slitrk6-deficient mice.	MYO7A NTF3	4.91e-04	14	82	2	19936227
Pubmed	Expansion and diversification of KRAB zinc-finger genes within a cluster including Regulator of sex-limitation 1 and 2.	ZNF729 ZNF107	5.65e-04	15	82	2	15885501
Pubmed	Association of CPI-17 with protein kinase C and casein kinase I.	CSNK1D CSNK1E	5.65e-04	15	82	2	15003508
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	ZNF462 ZNF567 ZNF136 BRIP1 BTAF1 SMARCAD1 ZNF292	5.91e-04	608	82	7	36089195
Pubmed	USP7 Is a Tumor-Specific WNT Activator for APC-Mutated Colorectal Cancer by Mediating β-Catenin Deubiquitination.	CSNK1D CSNK1E	6.45e-04	16	82	2	29045831
Pubmed	Expression of Neurog1 instead of Atoh1 can partially rescue organ of Corti cell survival.	MYO7A NTF3	6.45e-04	16	82	2	22292060
Pubmed	ARMC5 is part of an RPB1-specific ubiquitin ligase implicated in adrenal hyperplasia.	USP5 IRS4 SAMHD1 LRRC47	6.55e-04	166	82	4	35687106
Pubmed	Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain.	ZNF473 SMARCAD1 LRRC47	7.84e-04	76	82	3	10574461
Pubmed	Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo.	ZNF473 TRPS1 NAV2 SAMHD1 ABCB1	1.06e-03	326	82	5	17015433
Pubmed	Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937.	ZNF136 ZNF283	1.12e-03	21	82	2	7865130
Pubmed	Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia.	CSNK1D CSNK1E	1.12e-03	21	82	2	19839995
Pubmed	Trans-differentiation of outer hair cells into inner hair cells in the absence of INSM1.	BRIP1 MYO7A	1.23e-03	22	82	2	30305733
Pubmed	Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene.	CSNK1D CSNK1E	1.23e-03	22	82	2	22305495
Pubmed	Tbx2 is a master regulator of inner versus outer hair cell differentiation.	BRIP1 MYO7A	1.35e-03	23	82	2	35508658
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	ZNF462 ZNF219 ZNF532 TRPS1 KLF17 ZNF692 ZNF292	1.44e-03	709	82	7	22988430
Pubmed	High-throughput screen for genes predominantly expressed in the ICM of mouse blastocysts by whole mount in situ hybridization.	BNC2 ZNF219 PATZ1	1.45e-03	94	82	3	16325481
Pubmed	Hedgehog signalling controls sinoatrial node development and atrioventricular cushion formation.	RYR2 MYBPC3	1.47e-03	24	82	2	34062094
Pubmed	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.	DNHD1 RHNO1	1.86e-03	27	82	2	17525332
Pubmed	Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression.	ZNF729 ZNF107	2.14e-03	29	82	2	14563677
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	KCNH8 PATZ1 ZNF282 ZNF292	2.28e-03	233	82	4	37704626
Interaction	LTBP2 interactions	ZNF136 ZNF320 ZNF766 ZNF107 ZNF282 ZNF646	1.28e-06	85	82	6	int:LTBP2
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	ZNF793 ZNF567 ZNF137P ZNF836 ZNF320 ZNF613 ZNF577 ZNF473 ZNF549 ZFP30 ZNF283 ZNF805 ZNF534 ZNF525 ZNF264 ZNF766 ZNF543 ZNF304	3.10e-12	1192	82	18	chr19q13
Cytoband	19q13.41	ZNF836 ZNF320 ZNF613 ZNF577 ZNF534 ZNF766	6.25e-09	78	82	6	19q13.41
Cytoband	19q13.12	ZNF793 ZNF567 ZFP30	3.00e-04	72	82	3	19q13.12
Cytoband	19q13.4	ZNF137P ZNF264 ZNF304	3.94e-04	79	82	3	19q13.4
Cytoband	19q13.43	ZNF549 ZNF805 ZNF543	5.22e-04	87	82	3	19q13.43
Cytoband	1q25.3	ZNF648 MR1	1.42e-03	31	82	2	1q25.3
Cytoband	3p22.1	SNRK ZNF619	2.35e-03	40	82	2	3p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr14q11	RPGRIP1 ZNF219 TTC5 TEP1	3.02e-03	332	82	4	chr14q11
Cytoband	Ensembl 112 genes in cytogenetic band chr12p13	USP5 NTF3 MRPL51 RHNO1	3.75e-03	353	82	4	chr12p13
Cytoband	12p13	USP5 NTF3	5.91e-03	64	82	2	12p13
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF729 ZNF462 ZNF793 ZNF567 ZNF34 BNC2 ZNF136 ZNF836 ZNF320 ZNF219 ZNF613 ZNF577 ZBTB17 ZNF473 ZNF556 ZNF334 ZNF532 ZNF337 ZNF559 PATZ1 ZNF648 ZNF549 ZFP30 ZNF735 ZNF283 TRPS1 ZNF805 JAZF1 ZNF534 ZNF525 ZNF264 ZNF766 KLF17 ZNF619 ZNF543 ZNF107 ZNF692 ZNF282 ZNF292 ZNF646 ZNF304	7.31e-42	718	64	41	28
Coexpression	BLANCO_MELO_MERS_COV_INFECTION_MCR5_CELLS_UP	ZNF462 DNHD1 EVC2 ZNF473 MYO7A TIGD3 ZNF543 PDZD2	4.08e-06	299	81	8	M34002
ToppCell	Adult-Epithelial-basal_cell-D175\|Adult / Lineage, Cell type, age group and donor	TRPM6 ZNF320 KCNH8 NTF3 CHP2	9.41e-06	153	82	5	9ee3e7f3f19a2474283c1c79045269686f35a541
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Fibroblasts-Pericyte_2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DNHD1 BNC2 KCNH8 ZNF549 RYR2	1.10e-05	158	82	5	7f5426585d0d299d2b48e5fcb349950feffdef33
ToppCell	LPS-antiTNF-Endothelial-Mes-Like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZNF577 SNRK ZNF385A ABCB1 ZNF304	1.10e-05	158	82	5	50df52d64d07178975563abd98ce4fddb9f2f7ef
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	ZNF793 NTF3 ZNF549 ZNF805 TIGD3	1.36e-05	165	82	5	3d2acdae0dd2b79a15f74158e8e566ce22b4218e
ToppCell	10x3'2.3-week_14-16-Hematopoietic-HSC/MPP_and_pro-LMPP\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ZNF219 ZNF334 ZNF559 ZNF805 TTC5	2.17e-05	182	82	5	69b5cae6fe3bbb0fc60bd2f71b6cfa6cbb0b00ee
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_Arw_fibro_(16)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	BNC2 NTF3 TRPS1 NAV2 RYR2	2.35e-05	185	82	5	7dcdc009c5681ee05dd18968f7e85c3403fe34af
ToppCell	Control-Lymphoid-T_Regulatory\|Lymphoid / Disease state, Lineage and Cell class	TRPS1 JAZF1 SAMHD1 ZNF282 ZNF292	2.35e-05	185	82	5	e481cacda0b6b25f5f0062b962df9a442053ac30
ToppCell	IPF-Endothelial-VE_Peribronchial\|Endothelial / Disease state, Lineage and Cell class	TRPM6 BNC2 ENPP2 NAV2 ABCB1	3.25e-05	198	82	5	b8bd1ba268480f54451648e01631b615a3401144
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW08-Mesenchymal\|GW08 / Sample Type, Dataset, Time_group, and Cell type.	CPA6 MYO7A MR1 SAMHD1 ZNF385A	3.41e-05	200	82	5	e5b7d9622b96bb20c81ac76b4e60e8b44fa9cca1
Drug	vinylene	ZNF462 ZNF219 EVC2 TRPS1 ZNF264 TEP1 ZNF107 ZNF304	2.62e-06	245	81	8	CID000006326
Disease	syndromic X-linked intellectual disability Najm type (implicated_via_orthology)	CSNK1D CSNK1E	1.44e-04	7	78	2	DOID:0060807 (implicated_via_orthology)
Disease	invasive ductal carcinoma (is_implicated_in)	CSNK1E ABCB1	3.74e-04	11	78	2	DOID:3008 (is_implicated_in)
Disease	actinic keratosis	BNC2 TRPS1	6.15e-04	14	78	2	EFO_0002496
Disease	phosphoglyceric acid measurement	NTF3 ZNF107	9.14e-04	17	78	2	EFO_0010523
Disease	skin aging measurement	BNC2 TRPS1 JAZF1 PKD1L3	1.37e-03	181	78	4	EFO_0008006
Disease	sunburn	BNC2 TRPS1 JAZF1	2.13e-03	96	78	3	EFO_0003958
Disease	suntan	BNC2 TRPS1 SAMHD1	2.60e-03	103	78	3	EFO_0004279

Protein segments in the cluster

Peptide	Gene	Start	Entry
NSRRKKGHFRQYPAH	ZNF280A	71	P59817
AHYKGNRHARRVKGI	ZNF385A	91	Q96PM9
LRHKQGKQHVSFRRV	FAM210A	81	Q96ND0
NKGTLRVHYKTVHLR	BNC2	1046	Q6ZN30
HKIRQEKGTRASNYR	DNHD1	2766	Q96M86
VANFLRKHRKHIRAY	CPA6	306	Q8N4T0
GRQIHKIRKQFFHAI	ABCB1	141	P08183
QKKRQSVSGLHRYLH	LRRC47	426	Q8N1G4
KYHAKNGHRTQIRVR	JAZF1	191	Q86VZ6
LRRFKHKAHSTYNGN	PDZD2	176	O15018
GLAKKYRDARTHQHI	CSNK1D	151	P48730
QASKRYHLSKRFGHR	EVC2	581	Q86UK5
NRTSRRKRYAEHKSH	NTF3	131	P20783
QRGIRLHYKNSIFHR	PPIL6	186	Q8IXY8
LKRQYNDHHSKLRGL	BRIP1	796	Q9BX63
GKIFRDVYHLNRHKL	PATZ1	361	Q9HBE1
KHRGIITLYRHQKAA	BTAF1	966	O14981
GKAYTKRSHLVSHQR	KLF17	291	Q5JT82
DKGKQKLRQLHTHRY	RYR2	4456	Q92736
KQHLPKRLHYANNRR	ENPP2	426	Q13822
KVELKRLQRHYNHSG	MR1	96	Q95460
KRGYLRKQKHGHRRY	IRS4	81	O14654
RKQKHGHRRYFVLKL	IRS4	86	O14654
AYQKHQNRARHSSRK	RHNO1	71	Q9BSD3
EHQVVSYSRRKHGKR	RPGRIP1	996	Q96KN7
KHHQHRYLRLDGKTQ	SMARCAD1	891	Q9H4L7
RNSLHRRAYQHKVGN	SAMHD1	366	Q9Y3Z3
NHYLAKSGHKRLIRD	NAV2	96	Q8IVL1
RNGNNSHLYQRHKKT	PKD1L3	151	Q7Z443
TVHKRYHRRKSQGRG	SNRK	521	Q9NRH2
LHHRFRALDRNKKGY	CHP2	31	O43745
IRGLRKKFRALHSNH	TCEAL7	76	Q9BRU2
LERHRRIHNGEKLYK	ZNF525	426	Q8N782
VRAFKAHYRHRLLGK	TIGD3	301	Q6B0B8
FSYKRNLIVHQRTHK	ZNF567	626	Q8N184
KHFRKYHLGLHNRTR	TRPS1	241	Q9UHF7
SNRYKRRHTGNKHFK	ZNF107	91	Q9UII5
CRHNRIKHKGIRKVY	ZNF532	1071	Q9HCE3
NLSRHQKIHARKNAY	ZNF793	381	Q6ZN11
NSNRHNARYTGKKHL	ZNF735	171	P0CB33
LIRHQRIHTGQKSYK	ZNF320	456	A2RRD8
EHQRVHTGEKAYKRR	ZNF549	236	Q6P9A3
AFNKRYSLVRHQKVH	ZNF549	621	Q6P9A3
GKAFRQYAHLTRHQR	ZFP30	276	Q9Y2G7
NIKDHYKHRGRNLRS	ZNF136	51	P52737
KSYLVVHQRTHRGEK	ZNF334	361	Q9HCZ1
LYRKYKHQRHSSGNR	TRPM6	541	Q9BX84
QLAKYNPRKHRAKRH	TEP1	376	Q99973
NKRIRYLYKHFNRHG	MRPL51	111	Q4U2R6
RLNRHQRSHTGEKLY	ZNF577	256	Q9BSK1
LKFSVYHVDRQRKHQ	SYT15B	281	X6R8R1
SLIRHKRAHSGQKLY	ZNF556	161	Q9HAH1
FLGHRIVRHAQKHYK	ZNF292	551	O60281
LRLHRIQHKGKDYSF	TTC5	391	Q8N0Z6
LIRHQRIHTGQKSYK	ZNF137P	171	P52743
RTYRHAGSLINHRKS	ZNF646	381	O15015
YHTQIHVRSTRGRNK	WDR44	726	Q5JSH3
ARHRKIHTGGRRYKC	ZNF534	411	Q76KX8
SFRNLKNKRDYHKHR	RIOK2	131	Q9BVS4
KAFNHRSYLKRHQRI	ZNF264	406	O43296
RSYLKRHQRIHTGEK	ZNF264	411	O43296
LLNLHKKRHSGEARY	ZBTB17	376	Q13105
GKAFNRRSHLKQHQR	ZNF543	401	Q08ER8
KSRLIYHQRVHTGEK	ZNF613	216	Q6PF04
TRKGIARHYRIKHNN	ZNF462	1671	Q96JM2
KAYSHRGTLQQHRRL	ZNF648	286	Q5T619
GKAYSRSSHLVRHQK	ZNF304	621	Q9HCX3
RIYSGVKTHIFNKHR	ZNF766	151	Q5HY98
KHIRLRTRGKHYVCN	ZNF559	286	Q9BR84
RYNSKLSRHQKIHTG	ZNF619	226	Q8N2I2
HFNKTGQRVYLHLRR	USP5	61	P45974
KAFNHRSYLKRHQRI	ZNF805	406	Q5CZA5
RSYLKRHQRIHTGEK	ZNF805	411	Q5CZA5
LKYHLQRHHREQRSG	ZNF219	541	Q9P2Y4
KTYSRKEHLQNHQRL	ZNF282	581	Q9UDV7
GRIFSNRQYLNHHKK	ZNF692	336	Q9BU19
RSKLVYHQRNHTGEK	ZNF836	846	Q6ZNA1
QRSYLNNHKRVHRSK	ZNF34	206	Q8IZ26
SSYNKHLRAHLGEKR	ZNF337	501	Q9Y3M9
IRHKRIHIRQNIYKC	ZNF729	196	A6NN14
RNYLVQHERTHARKK	ZNF473	686	Q8WTR7
VHQRFHTGEKLYQRK	ZNF283	616	Q8N7M2
GLAKKYRDARTHQHI	CSNK1E	151	P49674
LYHISGHLQRREKNK	KCNH8	171	Q96L42
HRSRKLHQQYRLARQ	MYO7A	801	Q13402
YRFKKDGQRHHLIIN	MYBPC3	501	Q14896