Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 TAAR2 GPR52 OR4D11 TSHR SSTR3 CRHR1 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 OR4D5 GNRHR HRH3	7.45e-11	884	139	27	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 INSRR OR4E2 OR4C45 TAAR2 GPR52 OR4D11 TSHR GRIN2B SSTR3 CR1 NFAM1 CRHR1 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 SCN7A OR4D5 GNRHR HRH3	6.81e-10	1353	139	32	GO:0004888
GeneOntologyMolecularFunction	olfactory receptor activity	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	3.43e-07	431	139	15	GO:0004984
GeneOntologyMolecularFunction	protein-hormone receptor activity	INSRR TSHR LHCGR ADIPOR1 GNRHR	3.64e-07	22	139	5	GO:0016500
GeneOntologyMolecularFunction	N,N-dimethylaniline monooxygenase activity	FMO1 FMO3 FMO6P	6.50e-06	6	139	3	GO:0004499
GeneOntologyMolecularFunction	trimethylamine monooxygenase activity	FMO1 FMO3	4.81e-05	2	139	2	GO:0034899
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	FMO1 FMO3 FMO6P CYP4X1	1.69e-04	40	139	4	GO:0016709
GeneOntologyMolecularFunction	G protein-coupled amine receptor activity	TAAR2 ADRB2 ADRB3 HRH3	1.86e-04	41	139	4	GO:0008227
GeneOntologyMolecularFunction	norepinephrine binding	ADRB2 ADRB3	2.86e-04	4	139	2	GO:0051380
GeneOntologyMolecularFunction	beta-adrenergic receptor activity	ADRB2 ADRB3	2.86e-04	4	139	2	GO:0004939
GeneOntologyMolecularFunction	hypotaurine monooxygenase activity	FMO1 FMO3	4.75e-04	5	139	2	GO:0047822
GeneOntologyBiologicalProcess	activation of adenylate cyclase activity	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	1.01e-07	34	140	6	GO:0007190
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 TAAR2 GPR52 OR4D11 TSHR SSTR3 CRHR1 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 OR4D5 LYN GNRHR HRH3	1.87e-07	1395	140	28	GO:0007186
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	2.58e-07	432	140	15	GO:0050911
GeneOntologyBiologicalProcess	positive regulation of adenylate cyclase activity	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	2.79e-07	40	140	6	GO:0045762
GeneOntologyBiologicalProcess	sensory perception of smell	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	6.56e-07	465	140	15	GO:0007608
GeneOntologyBiologicalProcess	positive regulation of cyclase activity	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	8.52e-07	48	140	6	GO:0031281
GeneOntologyBiologicalProcess	positive regulation of lyase activity	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	9.66e-07	49	140	6	GO:0051349
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	1.11e-06	485	140	15	GO:0050907
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 GRIN2B OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	2.22e-06	582	140	16	GO:0050906
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	2.88e-06	524	140	15	GO:0009593
GeneOntologyBiologicalProcess	regulation of adenylate cyclase activity	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	2.94e-06	59	140	6	GO:0045761
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	4.84e-06	547	140	15	GO:0007606
GeneOntologyBiologicalProcess	regulation of cyclase activity	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	7.41e-06	69	140	6	GO:0031279
GeneOntologyBiologicalProcess	detection of stimulus	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 GPR52 OR4D11 GRIN2B OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	8.28e-06	722	140	17	GO:0051606
GeneOntologyBiologicalProcess	regulation of lyase activity	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	1.03e-05	73	140	6	GO:0051339
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TSHR SSTR3 LHCGR ADRB3 HRH3	5.88e-05	61	140	5	GO:0007187
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	CACNA2D1 TSPOAP1 GJC2 GRIN2B DYSF CRHR1 LHCGR ADRB2 TRPM8 LYN OGA	7.70e-05	392	140	11	GO:0070588
GeneOntologyBiologicalProcess	positive regulation of molecular function	RALGAPA1 CACNA2D1 RELN VRK3 INSRR TRIM21 TSHR TRIM68 GRIN2B TRIM6 WRAP53 CR1 TRIM27 NFAM1 TRIM22 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 PXN LYN TSSK4	9.33e-05	1430	140	23	GO:0044093
GeneOntologyBiologicalProcess	sensory perception	RPGRIP1 OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 RBP3 OR4E2 OR4C45 OR4D11 GRIN2B OR4K14 OR1L8 OR10G3 OR4K1 TRPM8 OR4D5	1.18e-04	1072	140	19	GO:0007600
GeneOntologyBiologicalProcess	regulation of calcium ion transmembrane transport	CACNA2D1 GJC2 DYSF CRHR1 LHCGR ADRB2 LYN OGA	1.24e-04	218	140	8	GO:1903169
GeneOntologyBiologicalProcess	norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure	ADRB2 ADRB3	1.37e-04	3	140	2	GO:0002025
GeneOntologyBiologicalProcess	calcium ion transport	CACNA2D1 TSPOAP1 GJC2 GRIN2B DYSF TRIM27 CRHR1 LHCGR ADRB2 TRPM8 LYN OGA	1.87e-04	509	140	12	GO:0006816
GeneOntologyBiologicalProcess	taurine biosynthetic process	FMO1 FMO3	2.72e-04	4	140	2	GO:0042412
GeneOntologyBiologicalProcess	alkanesulfonate biosynthetic process	FMO1 FMO3	2.72e-04	4	140	2	GO:0046305
GeneOntologyBiologicalProcess	regulation of calcium ion transport	CACNA2D1 GJC2 DYSF TRIM27 CRHR1 LHCGR ADRB2 LYN OGA	3.69e-04	323	140	9	GO:0051924
GeneOntologyBiologicalProcess	positive regulation of DNA-binding transcription factor activity	RELN TRIM21 TRIM68 TRIM6 TRIM27 NFAM1 TRIM22 TSSK4	4.19e-04	261	140	8	GO:0051091
GeneOntologyBiologicalProcess	positive regulation of AMPA receptor activity	RELN ADRB2	4.51e-04	5	140	2	GO:2000969
GeneOntologyBiologicalProcess	dermatan sulfate biosynthetic process	UST DSEL	4.51e-04	5	140	2	GO:0030208
GeneOntologyBiologicalProcess	lipid localization	ABCA12 ZDHHC5 DYSF CRHR1 LHCGR SLC22A6 PLA2R1 OSBPL6 LYN ABCG8 SOAT2 HRH3	4.81e-04	565	140	12	GO:0010876
GeneOntologyBiologicalProcess	regulation of viral entry into host cell	TRIM21 TRIM68 TRIM6 TRIM22	5.30e-04	55	140	4	GO:0046596
Domain	GPCR_Rhodpsn_7TM	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4D10 OR4D9 OR4E2 TAAR2 GPR52 OR4D11 TSHR SSTR3 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 OR4D5 GNRHR HRH3	9.36e-11	670	136	24	IPR017452
Domain	7tm_1	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4D10 OR4D9 OR4E2 TAAR2 GPR52 OR4D11 TSHR SSTR3 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 OR4D5 GNRHR HRH3	1.16e-10	677	136	24	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4D10 OR4D9 OR4E2 TAAR2 GPR52 OR4D11 TSHR SSTR3 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 OR4D5 GNRHR HRH3	1.47e-10	685	136	24	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4D10 OR4D9 OR4E2 TAAR2 GPR52 OR4D11 TSHR SSTR3 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 OR4D5 GNRHR HRH3	1.76e-10	691	136	24	PS50262
Domain	GPCR_Rhodpsn	OR5M10 GPR18 OR5M1 OR4N5 OR1B1 OR4D10 OR4D9 OR4E2 TAAR2 GPR52 OR4D11 TSHR SSTR3 OR4K14 OR1L8 LHCGR ADORA2B ADRB2 ADRB3 OR10G3 OR4K1 OR4D5 GNRHR HRH3	1.81e-10	692	136	24	IPR000276
Domain	Olfact_rcpt	OR5M10 OR5M1 OR4N5 OR1B1 OR4D10 OR4D9 OR4E2 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	6.08e-06	393	136	13	IPR000725
Domain	TF_fork_head_CS_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.05e-05	46	136	5	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.28e-05	47	136	5	IPR018122
Domain	FH	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.80e-05	49	136	5	SM00339
Domain	FORK_HEAD_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.80e-05	49	136	5	PS00657
Domain	FORK_HEAD_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.80e-05	49	136	5	PS00658
Domain	Fork_head_dom	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.80e-05	49	136	5	IPR001766
Domain	FORK_HEAD_3	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.80e-05	49	136	5	PS50039
Domain	Forkhead	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.80e-05	49	136	5	PF00250
Domain	TMEM151	TMEM151B TMEM151A	5.26e-05	2	136	2	PF14857
Domain	Tmem151	TMEM151B TMEM151A	5.26e-05	2	136	2	IPR026767
Domain	BBOX	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	1.47e-04	69	136	5	SM00336
Domain	Butyrophylin	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	1.57e-04	70	136	5	IPR003879
Domain	-	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	1.68e-04	71	136	5	4.10.45.10
Domain	zf-B_box	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	1.80e-04	72	136	5	PF00643
Domain	ZF_BBOX	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	2.95e-04	80	136	5	PS50119
Domain	Znf_B-box	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	3.13e-04	81	136	5	IPR000315
Domain	Znf_B-box_chordata	TRIM21 TRIM27	3.13e-04	4	136	2	IPR020457
Domain	PRY	TRIM21 TRIM68 TRIM6 TRIM27	4.08e-04	48	136	4	SM00589
Domain	PRY	TRIM21 TRIM68 TRIM6 TRIM27	4.08e-04	48	136	4	IPR006574
Domain	SPRY	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	4.35e-04	87	136	5	SM00449
Domain	CUB	CSMD3 SEZ6L2 ST14 CUZD1	4.42e-04	49	136	4	PF00431
Domain	CUB	CSMD3 SEZ6L2 ST14 CUZD1	4.78e-04	50	136	4	SM00042
Domain	Flavin_mOase	FMO1 FMO3	5.19e-04	5	136	2	IPR000960
Domain	DiMe-aniline_mOase	FMO1 FMO3	5.19e-04	5	136	2	IPR012143
Domain	FMO-like	FMO1 FMO3	5.19e-04	5	136	2	PF00743
Domain	Flavin_mOase-like	FMO1 FMO3	5.19e-04	5	136	2	IPR020946
Domain	-	CSMD3 SEZ6L2 ST14 CUZD1	5.55e-04	52	136	4	2.60.120.290
Domain	CUB	CSMD3 SEZ6L2 ST14 CUZD1	5.97e-04	53	136	4	PS01180
Domain	SPRY	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	6.21e-04	94	136	5	PF00622
Domain	SPRY_dom	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	6.21e-04	94	136	5	IPR003877
Domain	B30.2/SPRY	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	6.52e-04	95	136	5	IPR001870
Domain	B302_SPRY	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	6.52e-04	95	136	5	PS50188
Domain	Gphrmn_rcpt_fam	TSHR LHCGR	7.75e-04	6	136	2	IPR002131
Domain	CUB_dom	CSMD3 SEZ6L2 ST14 CUZD1	7.88e-04	57	136	4	IPR000859
Domain	7TM_GPCR_Srsx	TAAR2 SSTR3 ADORA2B ADRB2 ADRB3	1.37e-03	112	136	5	SM01381
Domain	LRR_5	TSHR LHCGR	2.28e-03	10	136	2	PF13306
Domain	LRR_5	TSHR LHCGR	2.28e-03	10	136	2	IPR026906
Domain	ADR_fam	ADRB2 ADRB3	2.28e-03	10	136	2	IPR002233
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	6.41e-07	417	108	15	M4072
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR5M10 OR5M1 OR4N5 OR1B1 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	1.56e-06	389	108	14	M14091
Pathway	KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION	TAAR2 TSHR GRIN2B SSTR3 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 GNRHR HRH3	7.43e-06	272	108	11	M13380
Pathway	REACTOME_SENSORY_PERCEPTION	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 RBP3 OR4E2 OR4C45 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	2.60e-05	636	108	16	M41834
Pathway	WP_GPCRS_NONODORANT	GPR18 TSHR SSTR3 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 GNRHR HRH3	3.69e-05	266	108	10	MM15843
Pathway	REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS	TSHR LHCGR GNRHR	9.15e-05	12	108	3	M13070
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	TAAR2 TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	1.13e-04	143	108	7	MM15055
Pathway	PID_ARF6_PATHWAY	TSHR LHCGR ADRB2 PXN	1.42e-04	35	108	4	M86
Pathway	REACTOME_HORMONE_LIGAND_BINDING_RECEPTORS	TSHR LHCGR GNRHR	1.86e-04	15	108	3	MM14972
Pathway	REACTOME_G_ALPHA_S_SIGNALLING_EVENTS	TAAR2 TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	2.02e-04	157	108	7	M4904
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	GPR18 TAAR2 TSHR SSTR3 LHCGR ADORA2B ADRB2 ADRB3 GNRHR HRH3	2.19e-04	330	108	10	M18334
Pathway	REACTOME_CLASS_A_1_RHODOPSIN_LIKE_RECEPTORS	GPR18 TAAR2 TSHR SSTR3 LHCGR ADORA2B ADRB2 ADRB3 GNRHR HRH3	2.36e-04	333	108	10	MM14963
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	TAAR2 ADRB2 ADRB3 HRH3	2.91e-04	42	108	4	M5868
Pathway	REACTOME_AMINE_LIGAND_BINDING_RECEPTORS	TAAR2 ADRB2 ADRB3 HRH3	2.91e-04	42	108	4	MM14971
Pathway	REACTOME_GPCR_LIGAND_BINDING	GPR18 TAAR2 TSHR SSTR3 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 GNRHR HRH3	4.52e-04	430	108	11	MM15160
Pathway	WP_CATALYTIC_CYCLE_OF_MAMMALIAN_FLAVINCONTAINING_MONOOXYGENASES_FMOS	FMO1 FMO3	5.73e-04	5	108	2	M39449
Pathway	REACTOME_GPCR_LIGAND_BINDING	GPR18 TAAR2 TSHR SSTR3 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 GNRHR HRH3	8.35e-04	463	108	11	M507
Pathway	WP_GPCRS_CLASS_A_RHODOPSINLIKE	GPR18 GPR52 SSTR3 LHCGR ADORA2B ADRB2 ADRB3 HRH3	8.64e-04	260	108	8	M39397
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	6.79e-12	6	144	5	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	6.29e-11	8	144	5	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	1.41e-10	9	144	5	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	1.42e-09	13	144	5	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	1.42e-09	13	144	5	7957066
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	3.30e-09	15	144	5	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	3.30e-09	15	144	5	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	4.78e-09	16	144	5	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	4.78e-09	16	144	5	10208738
Pubmed	Unique features of TRIM5alpha among closely related human TRIM family members.	TRIM21 TRIM6 TRIM27 TRIM22	9.77e-09	7	144	4	17156811
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	TAAR2 TSHR SSTR3 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 GNRHR HRH3	1.24e-08	200	144	10	18240029
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	1.26e-08	19	144	5	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	1.67e-08	20	144	5	12812790
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR5M10 OR5M1 OR4N5 OR1B1 OR4D10 OR4E2 OR4C45 OR4D11 OR1L8 OR10G3 OR4K1 OR4D5	2.05e-08	340	144	12	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR5M10 OR5M1 OR4N5 OR1B1 OR4D10 OR4E2 OR4C45 OR4D11 OR1L8 OR10G3 OR4K1 OR4D5	2.05e-08	340	144	12	11802173
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.19e-08	21	144	5	9449667
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR5M10 OR5M1 OR4N5 OR1B1 OR4D10 OR4E2 OR4C45 OR4D11 OR1L8 OR10G3 OR4K1 OR4D5	2.26e-08	343	144	12	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR5M10 OR5M1 OR4N5 OR1B1 OR4D10 OR4E2 OR4C45 OR4D11 OR1L8 OR10G3 OR4K1 OR4D5	2.49e-08	346	144	12	14611657
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	2.82e-08	22	144	5	17389379
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	4.53e-08	24	144	5	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	4.53e-08	24	144	5	29992973
Pubmed	The human olfactory receptor gene family.	OR5M10 OR5M1 OR4N5 OR1B1 OR4Q2 OR4D10 OR4D9 OR4E2 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1 OR4D5	6.38e-08	541	144	14	14983052
Pubmed	Targeted sequencing identifies genetic polymorphisms of flavin-containing monooxygenase genes contributing to susceptibility of nicotine dependence in European American and African American.	FMO1 FMO3 FMO6P	6.95e-08	3	144	3	28413702
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	6.96e-08	26	144	5	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	1.24e-07	29	144	5	22972626
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR5M1 OR4Q2 OR4D10 OR4E2 OR4D11 OR4K14 OR1L8 OR10G3 OR4K1	3.60e-07	219	144	9	12213199
Pubmed	Selective inhibition of heterotrimeric Gs signaling. Targeting the receptor-G protein interface using a peptide minigene encoding the Galpha(s) carboxyl terminus.	TSHR CRHR1 LHCGR ADORA2B ADRB2 ADRB3	4.78e-07	70	144	6	12036966
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L6 FOXD4L5 FOXD4L4	6.91e-07	5	144	3	12234674
Pubmed	Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans.	FMO1 FMO3 FMO6P	1.38e-06	6	144	3	12527699
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	FMO1 FMO3 INSRR SSTR3 CRHR1 LHCGR ADRB2 UGT2B4 GNRHR	2.38e-06	275	144	9	20734064
Pubmed	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	RELN GRIN2B SSTR3 CRHR1 LHCGR ADORA2B ADRB2 LYN GNRHR	4.82e-06	300	144	9	19086053
Pubmed	Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy.	FMO1 FMO3 FMO6P UGT2B4 UGT2B28	8.28e-06	66	144	5	19898482
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L1 FOXD4L3	8.91e-06	67	144	5	22711520
Pubmed	Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone.	CRHR1 ADORA2B ADIPOR1 ADRB2 ADRB3 HRH3	9.73e-06	117	144	6	18996102
Pubmed	Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.	FOXD4L4 FOXD4L1 FOXD4L3	1.12e-05	11	144	3	12421752
Pubmed	Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing.	TSHR LHCGR	1.70e-05	2	144	2	2293030
Pubmed	Influence of ADRB2 Gln27Glu and ADRB3 Trp64Arg polymorphisms on body weight and body composition changes after a controlled weight-loss intervention.	ADRB2 ADRB3	1.70e-05	2	144	2	26888112
Pubmed	Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate.	FMO1 FMO3	1.70e-05	2	144	2	34509493
Pubmed	Association of polymorphisms in the beta-2 and beta-3 adrenoceptor genes with risk of colorectal cancer in Japanese.	ADRB2 ADRB3	1.70e-05	2	144	2	11706779
Pubmed	Interactions among the beta2- and beta3- adrenergic receptor genes and total body fat and abdominal fat level in the HERITAGE Family Study.	ADRB2 ADRB3	1.70e-05	2	144	2	12629568
Pubmed	beta2- and beta3-, but not beta1-adrenergic receptors are involved in osteogenesis of mouse mesenchymal stem cells via cAMP/PKA signaling.	ADRB2 ADRB3	1.70e-05	2	144	2	20138019
Pubmed	Regulation of mouse liver flavin-containing monooxygenases 1 and 3 by sex steroids.	FMO1 FMO3	1.70e-05	2	144	2	9186481
Pubmed	An analysis of the link between polymorphisms of the beta2 and beta3 adrenergic receptor gene and metabolic parameters among Polish Caucasians with familial obesity.	ADRB2 ADRB3	1.70e-05	2	144	2	12824951
Pubmed	Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation.	ADRB2 ADRB3	1.70e-05	2	144	2	32755608
Pubmed	The genetic polymorphisms of beta3-adrenergic receptor (AR) Trp64Arg and beta2-AR Gln27Glu are associated with obesity in Chinese male hypertensive patients.	ADRB2 ADRB3	1.70e-05	2	144	2	17439327
Pubmed	The beta(2)-adrenergic receptor Arg16-gly polymorphism and interactions involving beta(2)- and beta(3)-adrenergic receptor polymorphisms are associated with variations in longitudinal serum lipid profiles: the Bogalusa Heart Study.	ADRB2 ADRB3	1.70e-05	2	144	2	15334382
Pubmed	Molecular and functional characteristics of β3-adrenoceptors in late pregnant mouse uterus: a comparison with β2-adrenoceptors.	ADRB2 ADRB3	1.70e-05	2	144	2	23219791
Pubmed	The relationship between birthweight and longitudinal changes of blood pressure is modulated by beta-adrenergic receptor genes: the Bogalusa Heart Study.	ADRB2 ADRB3	1.70e-05	2	144	2	20467565
Pubmed	Beta2-adrenoceptor polymorphisms relate to insulin resistance and sympathetic overactivity as early markers of metabolic disease in nonobese, normotensive individuals.	ADRB2 ADRB3	1.70e-05	2	144	2	16054001
Pubmed	Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding.	TSHR LHCGR	1.70e-05	2	144	2	1651314
Pubmed	Developmental and tissue-specific expression of human flavin-containing monooxygenases 1 and 3.	FMO1 FMO3	1.70e-05	2	144	2	16863467
Pubmed	Influence of FMO1 and 3 polymorphisms on serum olanzapine and its N-oxide metabolite in psychiatric patients.	FMO1 FMO3	1.70e-05	2	144	2	23147717
Pubmed	Severe gastrointestinal dysmotility developed after treatment with gonadotropin-releasing hormone analogs.	LHCGR GNRHR	1.70e-05	2	144	2	25592315
Pubmed	Beta2- and beta3-adrenergic receptor polymorphisms are related to the onset of weight gain and blood pressure elevation over 5 years.	ADRB2 ADRB3	1.70e-05	2	144	2	15956122
Pubmed	Localization of genes encoding three distinct flavin-containing monooxygenases to human chromosome 1q.	FMO1 FMO3	1.70e-05	2	144	2	8486388
Pubmed	Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes.	ADRB2 ADRB3	1.70e-05	2	144	2	11380082
Pubmed	Human hepatic flavin-containing monooxygenases 1 (FMO1) and 3 (FMO3) developmental expression.	FMO1 FMO3	1.70e-05	2	144	2	11809920
Pubmed	Epinephrine Activation of the β2-Adrenoceptor Is Required for IL-13-Induced Mucin Production in Human Bronchial Epithelial Cells.	ADRB2 MUC5AC	1.70e-05	2	144	2	26161982
Pubmed	Association of polymorphisms in the beta2 and beta3 adrenoceptor gene with polycystic ovary syndrome.	ADRB2 ADRB3	1.70e-05	2	144	2	16779985
Pubmed	No evidence for an association between genetic polymorphisms of beta(2)- and beta(3)-adrenergic receptor genes with body mass index in Aymara natives from Chile.	ADRB2 ADRB3	1.70e-05	2	144	2	11882399
Pubmed	Beta2- and beta3-adrenergic receptor polymorphisms and exercise hemodynamics in postmenopausal women.	ADRB2 ADRB3	1.70e-05	2	144	2	14715679
Pubmed	Genetic polymorphisms of beta2- and beta3-adrenergic receptor genes associated with characteristics of the metabolic syndrome in black South African women.	ADRB2 ADRB3	1.70e-05	2	144	2	18393130
Pubmed	Genetic factors and clinical significance of acanthosis nigricans in obese Japanese children and adolescents.	ADRB2 ADRB3	1.70e-05	2	144	2	16449022
Pubmed	[Polymorphisms in the beta2 and beta3 adrenergic receptor genes in obstructive sleep apnea/hypopnea syndrome].	ADRB2 ADRB3	1.70e-05	2	144	2	16009000
Pubmed	beta-Blockade and increased dyslipidemia in patients bearing Glu27 variant of beta2 adrenergic receptor gene.	ADRB2 ADRB3	1.70e-05	2	144	2	16027735
Pubmed	Gonadotropin-Releasing Hormone Stimulate Aldosterone Production in a Subset of Aldosterone-Producing Adenoma.	LHCGR GNRHR	1.70e-05	2	144	2	27196470
Pubmed	Impact of polymorphisms of human beta-adrenergic receptor gene on changes in height during growth hormone treatment.	ADRB2 ADRB3	1.70e-05	2	144	2	12008746
Pubmed	A case of primary aldosteronism in pregnancy: do LH and GNRH receptors have a potential role in regulating aldosterone secretion?	LHCGR GNRHR	1.70e-05	2	144	2	21330483
Pubmed	Beta-adrenoceptor subtype expression in human placenta and umbilical arteries in normal and preeclamptic pregnancies.	ADRB2 ADRB3	1.70e-05	2	144	2	18484422
Pubmed	Role for O-glycosylation of RFP in the interaction with enhancer of polycomb.	TRIM27 EPC1	1.70e-05	2	144	2	11779184
Pubmed	An intracellular loop (IL2) residue confers different basal constitutive activities to the human lutropin receptor and human thyrotropin receptor through structural communication between IL2 and helix 6, via helix 3.	TSHR LHCGR	1.70e-05	2	144	2	18162522
Pubmed	A conserved Asn in transmembrane helix 7 is an on/off switch in the activation of the thyrotropin receptor.	TSHR LHCGR	1.70e-05	2	144	2	11312274
Pubmed	Folic acid supplementation modifies beta-adrenoceptor-mediated in vitro lipolysis of obese/diabetic (+db/+db) mice.	ADRB2 ADRB3	1.70e-05	2	144	2	19596833
Pubmed	Possible association of beta2- and beta3-adrenergic receptor gene polymorphisms with susceptibility to breast cancer.	ADRB2 ADRB3	1.70e-05	2	144	2	11434877
Pubmed	Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties.	ADRB2 ADRB3	1.70e-05	2	144	2	15123695
Pubmed	Identification of an interactive effect of beta3- and alpha2b-adrenoceptor gene polymorphisms on fat mass in Caucasian women.	ADRB2 ADRB3	1.70e-05	2	144	2	11147800
Pubmed	Beta-adrenergic receptor polymorphisms in patients with elevated factor VIII levels with venous thrombosis.	ADRB2 ADRB3	1.70e-05	2	144	2	14510956
Pubmed	beta2- and beta3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals.	ADRB2 ADRB3	1.70e-05	2	144	2	17378367
Pubmed	β-Adrenergic receptor expression in vascular tumors.	ADRB2 ADRB3	1.70e-05	2	144	2	22743651
Pubmed	RIM-binding protein 2 regulates release probability by fine-tuning calcium channel localization at murine hippocampal synapses.	TSPOAP1 RIMBP2	1.70e-05	2	144	2	27671655
Pubmed	Insights into differential modulation of receptor function by hinge region using novel agonistic lutropin receptor and inverse agonistic thyrotropin receptor antibodies.	TSHR LHCGR	1.70e-05	2	144	2	22309849
Pubmed	The implications of polymorphisms in mammalian flavin-containing monooxygenases in drug discovery and development.	FMO1 FMO3	1.70e-05	2	144	2	15203093
Pubmed	The tripartite motif family identifies cell compartments.	TRIM21 TRIM6 TRIM27 TRIM22	2.53e-05	41	144	4	11331580
Pubmed	Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy.	ADRB2 ADRB3	5.09e-05	3	144	2	18801900
Pubmed	Association between accumulation of visceral fat and the combination of β3 adrenergic receptor Trp64Arg, β2 adrenergic receptor Arg16Gly and uncoupling protein 1 -3826A>G polymorphisms detected by Smart Amplification Process 2.	ADRB2 ADRB3	5.09e-05	3	144	2	21959333
Pubmed	Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation.	ADRB2 ADRB3	5.09e-05	3	144	2	11013230
Pubmed	Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice.	ADRB2 ADRB3	5.09e-05	3	144	2	28752049
Pubmed	Differential expression and role of hyperglycemia induced oxidative stress in epigenetic regulation of β1, β2 and β3-adrenergic receptors in retinal endothelial cells.	ADRB2 ADRB3	5.09e-05	3	144	2	24885710
Pubmed	The extreme C-terminal region of Gαs differentially couples to the luteinizing hormone and beta2-adrenergic receptors.	LHCGR ADRB2	5.09e-05	3	144	2	21622536
Pubmed	Variants in the human beta 1-, beta 2-, and beta 3-adrenergic receptor genes are not associated with morbid obesity in children and adolescents.	ADRB2 ADRB3	5.09e-05	3	144	2	15479221
Pubmed	betaAR signaling required for diet-induced thermogenesis and obesity resistance.	ADRB2 ADRB3	5.09e-05	3	144	2	12161655
Pubmed	Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.	ADRB2 ADRB3	5.09e-05	3	144	2	21138422
Pubmed	Uroguanylin Action in the Brain Reduces Weight Gain in Obese Mice via Different Efferent Autonomic Pathways.	ADRB2 ADRB3	5.09e-05	3	144	2	26566631
Pubmed	Nebulized Menthol Impairs Mucociliary Clearance via TRPM8 and MUC5AC/MUC5B in Primary Airway Epithelial Cells.	TRPM8 MUC5AC	5.09e-05	3	144	2	36675209
Pubmed	Lys418Asn polymorphism of the alpha2-adrenoceptor gene relates to serum uric acid levels but not to insulin sensitivity.	ADRB2 ADRB3	5.09e-05	3	144	2	15939803
Pubmed	Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.	ADRB2 ADRB3	5.09e-05	3	144	2	23473322
Pubmed	Norepinephrine induces lipolysis in beta1/beta2/beta3-adrenoceptor knockout mice.	ADRB2 ADRB3	5.09e-05	3	144	2	15939797
Pubmed	Tyrosine sulfation is required for agonist recognition by glycoprotein hormone receptors.	TSHR LHCGR	5.09e-05	3	144	2	11847099
Pubmed	Impact of variation in ADRB2, ADRB3, and GNB3 genes on body mass index and waist circumference in a Brazilian population.	ADRB2 ADRB3	5.09e-05	3	144	2	16493638
Pubmed	Association between body fat response to exercise training and multilocus ADR genotypes.	ADRB2 ADRB3	5.09e-05	3	144	2	15166301
Cytoband	9q21.11	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	2.39e-06	30	144	4	9q21.11
Cytoband	11q12.1	OR5M10 OR5M1 OR4D10 OR4D9 ZDHHC5 OR4D11	1.27e-05	161	144	6	11q12.1
Cytoband	14q11.2	OR4N5 OR4Q2 OR4E2 OR4K14 OR10G3 OR4K1	2.38e-05	180	144	6	14q11.2
Cytoband	1q24.3	FMO1 FMO3 FMO6P	3.31e-05	20	144	3	1q24.3
Cytoband	Ensembl 112 genes in cytogenetic band chr14q11	RPGRIP1 OR4N5 OR4Q2 OR4E2 OR4K14 OR10G3 OR4K1	9.15e-05	332	144	7	chr14q11
Cytoband	Ensembl 112 genes in cytogenetic band chr11q12	OR5M10 OR5M1 OR4D10 OR4D9 ZDHHC5 OR4D11 SLC22A6	1.16e-04	345	144	7	chr11q12
Cytoband	Ensembl 112 genes in cytogenetic band chr1q24	FMO1 FMO3 NTMT2 FMO6P	7.54e-04	129	144	4	chr1q24
GeneFamily	Olfactory receptors, family 4	OR4N5 OR4Q2 OR4D10 OR4D9 OR4E2 OR4C45 OR4D11 OR4K14 OR4K1 OR4D5	1.45e-09	129	95	10	151
GeneFamily	Glycoprotein hormone receptors	TSHR LHCGR	8.17e-05	3	95	2	199
GeneFamily	Ring finger proteins\|Tripartite motif containing\|ARF GTPase family	TRIM21 TRIM68 TRIM6 TRIM27 TRIM22	1.44e-04	95	95	5	59
GeneFamily	Adrenoceptors	ADRB2 ADRB3	9.60e-04	9	95	2	169
Drug	2-fluoronorepinephrine	ADRB2 ADRB3 HRH3	4.69e-06	6	142	3	CID000172745
Drug	hexoprenaline	CACNA2D1 ADRB2 ADRB3	1.30e-05	8	142	3	CID000003609
Drug	Sgd 101/75	CACNA2D1 ADRB2 ADRB3	1.30e-05	8	142	3	CID000121924
Drug	fenthion sulfoxide	FMO1 FMO3 DBT	1.94e-05	9	142	3	CID000019577
Drug	melatonin	ARHGAP9 GRIN2B PPAT BHLHE40 CLIP1 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 CYP4X1 NCOA1	2.26e-05	443	142	12	CID000000896
Drug	St-587	CACNA2D1 ADRB2 ADRB3	2.76e-05	10	142	3	CID000114696
Drug	nylidrin	GRIN2B ADRB2 ADRB3	2.76e-05	10	142	3	CID000004567
Drug	detomidine	LBR ADRB2 ADRB3	2.76e-05	10	142	3	CID000056031
Drug	amitriptyline	CACNA2D1 GDPD3 DYSF ADORA2B ADRB2 ADRB3 HRH3	2.85e-05	140	142	7	CID000002160
Drug	N,N-dimethylaniline-N-oxide	FMO1 FMO3 FMO6P	3.78e-05	11	142	3	CID000000950
Drug	Cetrorelix	LHCGR GNRHR	3.86e-05	2	142	2	DB00050
Drug	Goserelin	LHCGR GNRHR	3.86e-05	2	142	2	DB00014
Drug	Buserelin	LHCGR GNRHR	3.86e-05	2	142	2	DB06719
Drug	AN-201	RELN SSTR3 NDC80 GNRHR	4.00e-05	31	142	4	CID000119196
Drug	BDF 6143	ADRB2 ADRB3 HRH3	5.01e-05	12	142	3	CID000131283
Drug	metoprolol	CACNA2D1 SSTR3 ADORA2B ADRB2 ADRB3 HRH3	5.13e-05	105	142	6	CID000004171
Drug	forskolin from Coleus forskohlii	CACNA2D1 COL10A1 GPR18 RBP3 TSHR SSTR3 BHLHE40 CRHR1 LHCGR ADORA2B ADRB2 ADRB3 NDC80 SCN7A NCOA1 DSEL GNRHR HRH3	6.14e-05	1013	142	18	CID000003413
Drug	dimethindene	ADRB2 ADRB3 HRH3	6.49e-05	13	142	3	CID000021855
Drug	guanethidine	CACNA2D1 FMO1 FMO3 ADORA2B ADRB2 ADRB3	7.73e-05	113	142	6	CID000003518
Drug	rilmenidine	CACNA2D1 GRIN2B ADRB2 ADRB3	8.16e-05	37	142	4	CID000068712
Drug	methyl p-tolyl sulfide	FMO1 FMO3 FMO6P	8.22e-05	14	142	3	CID000069334
Drug	carteolol	CACNA2D1 ADRB2 ADRB3 NDC80 CYP4X1	8.79e-05	72	142	5	CID000002583
Drug	indoline	WDR7 SLC22A6 ADRB3 SOAT2	1.01e-04	39	142	4	CID000010328
Drug	arbutamine	ADRB2 ADRB3	1.15e-04	3	142	2	ctd:C076559
Drug	N-(3-hydroxy-1-(naphthalen-1-yl)-1,8,11-trioxa-5-azatridecan-13-yl)-6-(2-(2-(4,4-difluoro-4,4a-dihydro-5-(thiophen-2-yl)-4-bora-3a,4a-diaza-s-indacene-3-yl)vinyl)phenoxyacetamido)hexanamide	ADRB2 ADRB3	1.15e-04	3	142	2	ctd:C568515
Drug	3-iodopindolol	ADRB2 ADRB3	1.15e-04	3	142	2	CID000123825
Drug	p-azidobenzylcarazolol	ADRB2 ADRB3	1.15e-04	3	142	2	CID000133262
Drug	Fenoterol	ADRB2 ADRB3	1.15e-04	3	142	2	DB01288
Drug	LCB 2183	ADRB2 ADRB3	1.15e-04	3	142	2	CID000133046
Drug	U-43,465F	ADRB2 ADRB3	1.15e-04	3	142	2	CID000134388
Drug	Arbutamine	ADRB2 ADRB3	1.15e-04	3	142	2	DB01102
Drug	broxaterol	ADRB2 ADRB3	1.15e-04	3	142	2	ctd:C045916
Drug	pBABC	ADRB2 ADRB3	1.15e-04	3	142	2	CID000126676
Drug	EXP063	ADRB2 ADRB3	1.15e-04	3	142	2	CID003037493
Drug	ICYP-azide-2	ADRB2 ADRB3	1.15e-04	3	142	2	CID003036190
Drug	BAM-CYP	ADRB2 ADRB3	1.15e-04	3	142	2	CID000125252
Drug	butofilolol	ADRB2 ADRB3	1.15e-04	3	142	2	CID000068838
Drug	soquinolol	ADRB2 ADRB3	1.15e-04	3	142	2	CID000068811
Drug	CS 476	ADRB2 ADRB3	1.15e-04	3	142	2	CID000100459
Drug	butyl p-tolyl sulfide	FMO1 FMO3	1.15e-04	3	142	2	CID000304040
Drug	exaprolol	ADRB2 ADRB3	1.15e-04	3	142	2	CID000065484
Drug	AHR-9377	ADRB2 ADRB3	1.15e-04	3	142	2	CID000054961
Drug	dicyclopropyl ketoxime	ADRB2 ADRB3	1.15e-04	3	142	2	CID000015072
Drug	Oberadilol	ADRB2 ADRB3	1.15e-04	3	142	2	CID003047798
Drug	CGP-12177-NBD	ADRB2 ADRB3	1.15e-04	3	142	2	CID003081105
Drug	Bupranolol	ADRB2 ADRB3	1.15e-04	3	142	2	DB08808
Drug	p-azidoclonidine	ADRB2 ADRB3	1.15e-04	3	142	2	CID003035819
Drug	ICYP-azide-1	ADRB2 ADRB3	1.15e-04	3	142	2	CID000133837
Drug	AC1L4W2Z	ADRB2 ADRB3	1.15e-04	3	142	2	CID000193350
Drug	GS 332	ADRB2 ADRB3	1.15e-04	3	142	2	CID003041006
Drug	H 216/44	ADRB2 ADRB3	1.15e-04	3	142	2	CID000130141
Drug	AC1L1TT8	ADRB2 ADRB3	1.15e-04	3	142	2	CID000060729
Drug	ADATN	ADRB2 ADRB3	1.15e-04	3	142	2	CID000133861
Drug	imipramine	FMO1 FMO3 TSPOAP1 GDPD3 GRIN2B FMO6P ADRB2 ADRB3	1.17e-04	235	142	8	CID000003696
Drug	N6-(phenylisopropyl)adenosine	TSHR ADORA2B ADRB2 ADRB3	1.23e-04	41	142	4	CID000034507
Drug	NBI-27914	TSPOAP1 GRIN2B CRHR1	1.25e-04	16	142	3	CID000176157
Drug	8-azaguanine	PPAT ST14 FCGRT UGT2B4 UGT2B28	1.29e-04	78	142	5	CID000008646
Drug	tripelennamine	ADRB2 ADRB3 UGT2B4 HRH3	1.35e-04	42	142	4	CID000005587
Drug	methimazole	DPYSL3 FMO1 FMO3 TSHR FMO6P NCOA1	1.41e-04	126	142	6	CID001349907
Drug	ritodrine	CACNA2D1 ADRB2 ADRB3	1.51e-04	17	142	3	CID000031728
Drug	synephrine	TAAR2 ADRB2 ADRB3	1.81e-04	18	142	3	CID000007172
Drug	esmolol	CACNA2D1 ADRB2 ADRB3	1.81e-04	18	142	3	CID000059768
Drug	indolizine	CACNA2D1 FCGRT HRH3	1.81e-04	18	142	3	CID000009230
Drug	beta-hydroxyaspartic acid	BEAN1 GRIN2B FCGRT PROS1	2.10e-04	47	142	4	CID000005425
Drug	BRL 26830A	PPAT ADRB2 ADRB3	2.14e-04	19	142	3	CID006438331
Drug	v315	ADRB2 ADRB3	2.30e-04	4	142	2	CID000053925
Drug	NHNPNBE	ADRB2 ADRB3	2.30e-04	4	142	2	CID006453817
Drug	eclanamine	ADRB2 ADRB3	2.30e-04	4	142	2	CID000051228
Drug	Tobanum	ADRB2 ADRB3	2.30e-04	4	142	2	CID000065814
Drug	Gs-Cbl	MTR PROS1	2.30e-04	4	142	2	CID006450098
Drug	flestolol	ADRB2 ADRB3	2.30e-04	4	142	2	CID000055884
Drug	DAPN	ADRB2 ADRB3	2.30e-04	4	142	2	CID000125184
Drug	SOM-1122	ADRB2 ADRB3	2.30e-04	4	142	2	CID000068918
Drug	tienoxolol	ADRB2 ADRB3	2.30e-04	4	142	2	CID000065678
Drug	Alp-NBD	ADRB2 ADRB3	2.30e-04	4	142	2	CID000126953
Drug	i 583	ADRB2 ADRB3	2.30e-04	4	142	2	CID000072881
Drug	cyanopindolol	ADRB2 ADRB3	2.30e-04	4	142	2	ctd:C047975
Drug	Benzydamine	FMO1 FMO3	2.30e-04	4	142	2	ctd:D001591
Drug	acebutolol azide	ADRB2 ADRB3	2.30e-04	4	142	2	CID000133410
Drug	CGP 20712A	ADRB2 ADRB3	2.30e-04	4	142	2	ctd:C049763
Drug	iodoazidobenzylpindolol	ADRB2 ADRB3	2.30e-04	4	142	2	CID000132676
Drug	4-(1H-imidazol-4-ylmethyl)piperidine	ADRB2 HRH3	2.30e-04	4	142	2	ctd:C085755
Drug	demeton-O	FMO1 FMO3	2.30e-04	4	142	2	CID000009273
Drug	Fusaric acid [536-69-6]; Up 200; 22.4uM; PC3; HT_HG-U133A	RALGAPA1 CACNA2D1 COL10A1 GDPD3 SLC22A6 OGA GNRHR	2.35e-04	196	142	7	3986_UP
Drug	idazoxan	CACNA2D1 ADORA2B ADRB2 ADRB3 HRH3	2.40e-04	89	142	5	CID000054459
Drug	chlorpromazine	DAGLB CACNA2D1 FMO1 FMO3 GDPD3 ADRB2 ADRB3	2.42e-04	197	142	7	CID000002726
Drug	arotinolol	CACNA2D1 ADRB2 ADRB3	2.51e-04	20	142	3	CID000002239
Disease	S-methylcysteine measurement	FMO3 FMO6P	1.93e-05	2	130	2	EFO_0800054
Disease	heart septal defect	WDR7 YTHDC2	2.86e-04	6	130	2	MONDO_0002078
Disease	uronyl 2-sulfotransferase measurement	DAGLB UST	3.99e-04	7	130	2	EFO_0803240
Disease	cholesteryl ester 24:4 measurement	ABCG8 SOAT2	3.99e-04	7	130	2	EFO_0021447
Disease	hyperthyroidism	TSHR TRIM27 MUC22	4.93e-04	35	130	3	EFO_0009189
Disease	obesity (is_implicated_in)	CRHR1 ADRB2 ADRB3 ABCG8	7.15e-04	91	130	4	DOID:9970 (is_implicated_in)
Disease	multisite chronic pain	MON1B ZCCHC4 CEP120 SLC25A13	8.40e-04	95	130	4	EFO_0010100
Disease	Thromboembolism	TRIM21 TRIM6 TRIM22	9.70e-04	44	130	3	HP_0001907
Disease	granulosa cell tumor (is_marker_for)	ST14 LHCGR	1.03e-03	11	130	2	DOID:2999 (is_marker_for)
Disease	Adrenal Gland Neoplasms	TSHR GNRHR	1.03e-03	11	130	2	C0001624
Disease	Adrenal Cancer	TSHR GNRHR	1.03e-03	11	130	2	C0750887
Disease	Autistic Disorder	RELN GRIN2B CSMD3 SEZ6L2 ADRB2 SCN7A	1.08e-03	261	130	6	C0004352
Disease	gastric ulcer (implicated_via_orthology)	MUC5AC HRH3	1.69e-03	14	130	2	DOID:10808 (implicated_via_orthology)
Disease	dystonia (is_implicated_in)	TSPOAP1 TMEM151A	1.69e-03	14	130	2	DOID:543 (is_implicated_in)
Disease	lentiform nucleus measurement	FMO3 FMO6P	1.69e-03	14	130	2	EFO_0004913
Disease	hypertension (is_implicated_in)	FMO3 ADRB2 ADRB3 MTR	2.05e-03	121	130	4	DOID:10763 (is_implicated_in)
Disease	response to beta blocker, heart rate	TAAR2 ARHGAP9 TMEM131L	2.06e-03	57	130	3	EFO_0004326, EFO_0007766
Disease	Lipidemias	ADRB2 ADRB3	2.51e-03	17	130	2	C1706412
Disease	Hyperlipidemia	ADRB2 ADRB3	2.51e-03	17	130	2	C0020473
Disease	cystic fibrosis (is_marker_for)	ADRB2 ADRB3 MUC5AC	2.61e-03	62	130	3	DOID:1485 (is_marker_for)
Disease	acute pancreatitis	ADRB2 ABCG8	2.81e-03	18	130	2	EFO_1000652
Disease	phosphatidylcholine 36:4 measurement	UGT2B4 UGT2B28	2.81e-03	18	130	2	EFO_0010382
Disease	osteoarthritis	DAGLB RELN CSMD3 BHLHE40 SLC25A13	3.08e-03	222	130	5	MONDO_0005178
Disease	temporal lobe epilepsy (is_marker_for)	RELN GRIN2B	3.47e-03	20	130	2	DOID:3328 (is_marker_for)
Disease	polycystic ovary syndrome (biomarker_via_orthology)	ADRB2 ADRB3	3.83e-03	21	130	2	DOID:11612 (biomarker_via_orthology)
Disease	testosterone measurement	DAGLB CACNA2D1 FMO3 ARHGAP9 WRAP53 CSMD3 LHCGR CEP120 FCGRT UGT2B4 NCOA1 RIMBP2 DNMBP	4.19e-03	1275	130	13	EFO_0004908

Protein segments in the cluster

Peptide	Gene	Start	Entry
CKPEFRFGYPVCSYV	EOGT	86	Q5NDL2
PFAFRRKAGCQYYAP	EPC1	401	Q9H2F5
YVNSGFNPLIYCRSP	ADRB2	316	P07550
GYTLIYTCQPGFFLA	CSMD3	3431	Q7Z407
AIPYTGPFNLLCYQL	CPSF3	516	Q9UKF6
YMVYFNFFGCVLPPL	ADORA2B	181	P29275
PLSRPFQLGNYCNFY	CCAR1	406	Q8IX12
FSEFRTYSFPCYLPQ	CDK18	371	Q07002
YGIPINSTPFCFSLY	ABCA12	771	Q86UK0
FCLPFYLIPPSATAY	BHLHE40	321	O14503
LYMYCTEPFRIPFAG	ATP13A1	511	Q9HD20
GRFIPCSPFSDYVYK	DPYSL3	466	Q14195
EYFCQILGALTVFYP	GPR18	91	Q14330
VQYFTAIGYPCPRYS	ABCG8	301	Q9H221
GFVYSSFLKPYNPRR	DNMBP	1336	Q6XZF7
YANSAFNPLIYCRSP	ADRB3	336	P13945
VPFAVCVVSRFPYYN	DENND3	106	A2RUS2
PYIPFRDAAYGSCNF	CDC14C	131	A4D256
FSVRAKQTYPYCALP	ATXN7L2	331	Q5T6C5
FYGTLFCMYVRPPSE	OR5M10	251	Q6IEU7
QVFLARYSYNPFEGP	TSPOAP1	656	O95153
PCGFNHILPYFYIIY	LBR	561	Q14739
CLPRFNPDGFFYAYV	MON1B	326	Q7L1V2
VLKPNYVCFFGYPSF	DBT	31	P11182
FVPCIYVYARPFTAL	OR4D11	251	Q8NGI4
YPTIPAARCLAQFFF	OR1B1	91	Q8NGR6
FLYGTIICVYFQPPF	OR1B1	256	Q8NGR6
YSFYCSPQPRLIYLS	ADIPOR1	226	Q96A54
VYFGPCSPYQFRLVG	FMO3	461	P31513
FYPINSCANPFLYAI	LHCGR	611	P22888
RNLFFPLRYCGIYYP	MUC22	1686	E2RYF6
QYLLYGFEVRPFFPC	GJC2	231	Q5T442
VFYFPRCQGFTSVPS	CSRNP1	91	Q96S65
LSGICAFISGRFPYY	FOXD4L4	131	Q8WXT5
LSGICAFISGRFPYY	FOXD4L3	131	Q6VB84
LFRPSYGFNLTDPYC	FSIP2	76	Q5CZC0
CSAFSFYPPELQLRF	FCGRT	221	P55899
FVPCSYLYLRPLTSF	OR4C45	246	A6NMZ5
FGPCIYFYIWPFSRL	OR4K1	251	Q8NGD4
FFGPCIFVYVRPFSR	OR4K14	251	Q8NGD5
FGPAIFIYTCPFQAF	OR4N5	251	Q8IXE1
TLFFGPCIFIYARPF	OR4Q2	246	P0C623
GLFAPLPTYSYCKQI	DEPDC1	711	Q5TB30
FFCFLPNIINRTYFP	GDPD3	226	Q7L5L3
LEVYFGPCSPYQFRL	FMO6P	466	O60774
RTPSICPLFCDYYNP	MUC5AC	1156	P98088
KPIPFGGCVAQLYFY	OR10G3	91	Q8NGC4
RLPYCGPNQVDYFFC	OR10G3	166	Q8NGC4
AYFTGFIVCLLYAPA	GPR52	201	Q9Y2T5
YCSTYFRAGSKPFNP	OSBPL6	636	Q9BZF3
AAGYYPRFSPFFFLC	RELN	26	P78509
RSPPKYRPFLACFTY	MTERF2	21	Q49AM1
FVPCIYVYARPFTAL	OR4D9	251	Q8NGE8
NLFSPRCYYCNGPIL	PXN	411	P49023
PGYYVQRSCGLFTAP	HECTD1	2216	Q9ULT8
FAFLNPCFDPLIYGY	GNRHR	311	P30968
FEFPIGTYLNYECRP	CR1	61	P17927
TPRFTLCPNGYYFAI	CACNA2D1	501	P54289
PINCILRYSYPFFGS	CEP120	471	Q8N960
LRAAYPQVRCYAFSP	DAGLB	456	Q8NCG7
PRAYTYSAFFCPSER	CPAMD8	936	Q8IZJ3
LTVFFGPCSPYQFRL	FMO1	461	Q01740
PYAYLPFSAGSRNCI	CYP4X1	441	Q8N118
GVVCFFPSYEYLRQV	DDX12P	721	Q92771
RPCPAFFYGVRYNTT	CRHR1	66	P34998
YVPCARFLFGSSFPV	FAM166B	186	A8MTA8
FLVGAFCIPLYVPYV	HRH3	81	Q9Y5N1
GGYYISPRITFPCIS	LYN	191	P07948
RPSFRLLSFYYSPEC	INSRR	1251	P14616
SGICAFISGRFPYYR	FOXD4L1	131	Q9NU39
GFPSLSYGSRFCYPN	KRTAP13-4	121	Q3LI77
YYVPRPCQGSSFLPA	KRTAP26-1	86	Q6PEX3
FYYFFSPNISIPNCG	CUZD1	141	Q86UP6
PCPLARYNRTSYFYP	BEAN1	6	Q3B7T3
GPLQTPRYFAFAQEY	SBK3	106	P0C264
FAPNFPIYCAFRLLS	SLC22A6	181	Q4U2R8
VFYGPYINVSSCRFI	DSEL	681	Q8IZU8
YLGFLPTFGPCYINL	DYSF	511	O75923
CYINLYGSPREFTGF	DYSF	521	O75923
YFNPCYATARLKPTF	CRLS1	226	Q9UJA2
RYFQCQPKYGLFAPV	CLIP1	261	P30622
FVPCIYVYTRPFRTF	OR4D5	251	Q8NGN0
LFYGSIFCVYLQPPS	OR1L8	251	Q8NGR8
FVPCIYVYARPFTAL	OR4D10	251	Q8NGI6
CYSLQEFTPPFRRYD	NTMT2	171	Q5VVY1
YLCPVYISFFGLGAV	SLC5A7	326	Q9GZV3
DGPPSLTTICFYAFY	TAF5L	251	O75529
LCVARYSYNPFDGPN	RIMBP2	171	O15034
FCGPVRPYFSLSYSG	TRIM27	466	P14373
LGTQPSPYAVYRFFT	RPGRIP1	816	Q96KN7
IAFSPAQPLYACGSY	WRAP53	331	Q9BUR4
LPYANSCANPILYGF	SSTR3	301	P32745
VVCKEYYPGFNPFRA	TMEM131L	1566	A2VDJ0
SPCSNGYVYIPLAFL	TMEM151B	106	Q8IW70
YLGLTDPCQPYRSAF	NBPF12	1161	Q5TAG4
GCSPLFVYLVPYALS	SLC16A12	296	Q6ZSM3
GTFCYPNVSQSPYLR	OGA	221	O60502
PSGYRLRLFFYGVCN	SLC35G2	161	Q8TBE7
IYAFFQPQGREPSYA	NCOA1	296	Q15788
FYGTLFCMYVRPPSE	OR5M1	251	Q8NGP8
LPCTLPFEYIYFRSR	PNPLA5	346	Q7Z6Z6
LSGICAFISGRFPYY	FOXD4L5	131	Q5VV16
LSGICAFISGRFPYY	FOXD4L6	131	Q3SYB3
ISFSCRITYPYTPQF	NFAM1	61	Q8NET5
YVLCYPNAGLPNTFG	MTR	281	Q99707
TCFYQPAPYFAAEAR	TENT5D	346	Q8NEK8
YPTPLYFGTRGQFRC	SLC26A10	421	Q8NG04
ASPCSDGYLYIPLAF	TMEM151A	91	Q8N4L1
YRPGALATFSCLPGY	SEZ6L2	481	Q6UXD5
FYPKYLVCLRSFQTG	PROS1	81	P07225
LAGFRNPYYPATNFS	PLA2R1	1431	Q13018
PSFSSYLYFLFCPTL	SOAT2	266	O75908
LQPRIYCPFAGYFVE	CMAHP	246	Q9Y471
LRDIPFSAIYFPCYA	SLC25A13	491	Q9UJS0
TGIFTCQIPGIYYFS	COL10A1	586	Q03692
SNPRLFYIIPYFCGQ	UST	241	Q9Y2C2
FCTFVLAYAGYIPYP	PHF13	31	Q86YI8
VAYRSFNPFFPLLGC	ZYG11B	646	Q9C0D3
SFAYACPEILRGLPY	TSSK4	201	Q6SA08
GRLLPYFSPCYSIGT	TRIM68	456	Q6AZZ1
CVYGAQCFSNPRYFP	RALGAPA1	1436	Q6GYQ0
PGSYSTAIPLLCSYF	RBP3	786	P10745
RTQLPYEYYSLPFCQ	TM9SF4	51	Q92544
FGPCIFIYTRPDTSF	OR4E2	251	Q8NGC2
IPFVYSLRFSPGYAI	UGT2B4	166	P06133
VQLCGTYPPSYNLTF	ST14	291	Q9Y5Y6
PVAFCIFEYVYFARP	PPAT	276	Q06203
FPCLLYGAYAFLPFD	TMEM79	211	Q9BSE2
PPRGSQLCALYAFTY	ARHGAP9	21	Q9BRR9
FNSTCNPLIYGFFYP	TAAR2	306	Q9P1P5
QVTLAGYGFAFRYCP	VRK3	321	Q8IV63
KFCSFVLAYAGYIPP	PHF23	36	Q9BUL5
YSFSECAFTGPLRPF	TRIM21	431	P19474
PVCRVFPSYCFIYQS	TAMM41	396	Q96BW9
LFPGFRPAVEACYFN	ZSWIM8	471	A7E2V4
FFAFTCPGLSLYVSP	ZDHHC5	31	Q9C0B5
FIRYFGSCPVIYIQG	YTHDC2	356	Q9H6S0
FPYFFESRICQFFPS	ZCCHC4	316	Q9H5U6
CGNPSVGIFYFVSYI	SCN7A	1466	Q01118
CSRLNIPFPFIVFAY	TRPM8	1006	Q7Z2W7
IPFVYSLCFTPGYTI	UGT2B28	166	Q9BY64
IYKFSGCRFSRPAYP	TRIM22	466	Q8IYM9
GCRFSRPAYPYFNPW	TRIM22	471	Q8IYM9
CPPVTRFFYGCREYF	WDR7	326	Q9Y4E6
KYYFPTTLCPYFNPC	TRIM6	461	Q9C030
YCGLRKSFLYPPQES	TTC31	106	Q49AM3
SSYYDPGRLICDFPF	VPS39	671	Q96JC1
FYPLNSCANPFLYAI	TSHR	666	P16473
FLYGFLCPSYELPDT	NDC80	131	O14777
VFEYFSPVGYNRCLA	GRIN2B	576	Q13224