Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled peptide receptor activity

LGR4 MRGPRX3 GALR2 GPR139

3.40e-05133284GO:0008528
GeneOntologyMolecularFunctionpeptide receptor activity

LGR4 MRGPRX3 GALR2 GPR139

4.16e-05140284GO:0001653
GeneOntologyMolecularFunctionneuropeptide receptor activity

MRGPRX3 GALR2 GPR139

5.52e-0553283GO:0008188
GeneOntologyMolecularFunctionclathrin adaptor activity

HIP1R SNAP91

4.30e-0422282GO:0035615
GeneOntologyMolecularFunctioncargo adaptor activity

HIP1R SNAP91

5.58e-0425282GO:0140312
GeneOntologyMolecularFunctionneuropeptide binding

MRGPRX3 GALR2

1.23e-0337282GO:0042923
GeneOntologyBiologicalProcesspositive regulation of clathrin coat assembly

HIP1R SNAP91

9.15e-064262GO:1905445
GeneOntologyBiologicalProcessregulation of clathrin coat assembly

HIP1R SNAP91

3.20e-057262GO:1905443
GeneOntologyCellularComponentcoated vesicle membrane

HIP1R SNAP91 CNIH2 CFTR

1.84e-04215284GO:0030662
DomainANTH_dom

HIP1R SNAP91

1.21e-054272IPR011417
DomainANTH

HIP1R SNAP91

1.21e-054272PF07651
DomainENTH

HIP1R SNAP91

7.20e-059272PS50942
DomainENTH

HIP1R SNAP91

7.20e-059272SM00273
DomainENTH

HIP1R SNAP91

8.99e-0510272IPR013809
Domain-

HIP1R SNAP91

6.40e-04262721.25.40.90
DomainENTH_VHS

HIP1R SNAP91

7.98e-0429272IPR008942
DomainLRRNT

LGR4 FLRT2

2.65e-0353272PF01462
DomainLRRNT

LGR4 FLRT2

8.78e-0398272IPR000372
DomainLRRNT

LGR4 FLRT2

8.78e-0398272SM00013
DomainGPCR_Rhodpsn_7TM

LGR4 MRGPRX3 GALR2 GPR139

1.49e-02670274IPR017452
Domain7tm_1

LGR4 MRGPRX3 GALR2 GPR139

1.55e-02677274PF00001
DomainG_PROTEIN_RECEP_F1_1

LGR4 MRGPRX3 GALR2 GPR139

1.61e-02685274PS00237
DomainG_PROTEIN_RECEP_F1_2

LGR4 MRGPRX3 GALR2 GPR139

1.66e-02691274PS50262
DomainGPCR_Rhodpsn

LGR4 MRGPRX3 GALR2 GPR139

1.66e-02692274IPR000276
Pubmed

Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice.

ASIC5 STRA6

4.09e-043728216707424
Pubmed

ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.

ATP8A1 EPB41L3 SNAP91

5.68e-0420228333601422
InteractionCREB3L1 interactions

NAT8 NRM ALG8 CNIH2 CFTR

5.87e-06206265int:CREB3L1
GeneFamilyG protein-coupled receptors, Class A orphans

LGR4 MRGPRX3 GPR139

4.15e-0578163262
ToppCellPND01-03-samps-Mesenchymal-Myofibroblast|PND01-03-samps / Age Group, Lineage, Cell class and subclass

LGR4 ALG8 FLRT2 EPB41L3

4.92e-06182284812dac35b9aa05be48258082e007f6c00e7b4dd8
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLRT2 STRA6 GALR2

1.54e-041672831adb566f98af0109c8cc6e36033b89651e2c75e7
ToppCellfacs-Lung-3m-Mesenchymal-fibroblast-mesothelial_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLRT2 STRA6 GALR2

1.54e-04167283743df5908c1ceb43b34b240d9f9649f30f4142fa
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--|Striatum / BrainAtlas - Mouse McCarroll V32

DAP3 ALG8 ZDHHC23

1.59e-041692835375eb52ebadccb7bfff997a11985f23e81014d6
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)|Striatum / BrainAtlas - Mouse McCarroll V32

DAP3 ALG8 ZDHHC23

1.59e-04169283c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-|Striatum / BrainAtlas - Mouse McCarroll V32

DAP3 ALG8 ZDHHC23

1.59e-041692831c132d21255f5a5174ac38db4e91927f9093418e
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel-D122|Adult / Lineage, Cell type, age group and donor

FLRT2 GNA14 ZDHHC23

1.62e-04170283a99cb3d21f8eb926886340ea99491e078e607648
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l48|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NEK1 SWT1 TMEM64

1.62e-04170283070d8683d1a5cc7d594ff0453c961a9bf982c2d0
ToppCellAdult-Endothelial-endothelial_cell_of_bronchial_vessel|Adult / Lineage, Cell type, age group and donor

NRM FLRT2 GNA14

1.68e-04172283ad4ffdb3fc0c560a9cbaa2bc048476cbc43e8fd6
ToppCellE17.5-Epithelial-alveolar_epithelial_cell-type_II_pneumocyte|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ATP8A1 SWT1 CFTR

1.73e-0417428368914ec843f58ecff3e6412544a341daf8a01cac
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LGR4 USP3 CFTR

1.92e-04180283cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCelldroplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FLRT2 STRA6 EPB41L3

1.92e-04180283c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCellNS-critical-d_0-4-Epithelial-Ionocyte|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

LGR4 TMEM64 CFTR

1.95e-04181283cfc3ed541d93158ce26641ea30b7573d93600a11
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP8A1 TMEM64 CFTR

2.01e-041832836847c1252d6bb105524f812658112517fd351eab
ToppCell3'-GW_trimst-1-SmallIntestine-Epithelial-neuro-epithelial-K_cells_(GIP+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ASIC5 ZDHHC23 CNIH2

2.01e-04183283d23018193b9c0806e0d1a9ac15e6392eb8e96aaf
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Adult / Lineage, Cell type, age group and donor

ATP8A1 GNA14 CFTR

2.08e-04185283673f0c688ae6984bc8027df2da335787924f4137
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8 EPB41L3 TMEM64

2.08e-041852830ff4148b4701003d9d594e0da8261176fb13aa59
ToppCelldroplet-Kidney-nan-3m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8 EPB41L3 TMEM64

2.08e-041852833e3217c99719fd1d2fa94e16be7712a7e5077152
ToppCellEpithelial-C_(AT2)|World / shred on cell class and cell subclass (v4)

ATP8A1 SWT1 CFTR

2.11e-04186283b7b1763fc52b4485d843a4a6727055e6c95ebad3
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLRT2 ZDHHC23 DPY19L2P1

2.25e-0419028349e09cdb843b3d889a06a811aa5affae68b25a75
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLRT2 ZDHHC23 DPY19L2P1

2.25e-04190283d594da827e3c16644952b9589cc12b947ce36279
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8A1 SWT1 CFTR

2.28e-0419128308b1d3b3be78bf7fd9e9039027e35275f2be88d0
ToppCellE18.5-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ATP8A1 SWT1 CFTR

2.28e-04191283f896fb490c4a17adac5e00ed9b6e6145eab1e564
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

ATP8A1 TMEM64 CFTR

2.35e-04193283738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLRT2 GNA14 EPB41L3

2.35e-041932831f978e102a029a6beb10913052cd0a20c7253e8e
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory-Secretory_Goblet|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STRA6 GNA14 CFTR

2.46e-04196283c366f980cc04abfe1c0c14746c11810c812a42c0
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STRA6 GNA14 CFTR

2.46e-04196283b07db4a53ab9be9aad6fae5e45f9547db829d096
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LGR4 STRA6 CNIH2

2.50e-04197283107cb153ea7fc74bbd244dbb9d0499c0a8506724
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-cortical_neurons_1|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

FLRT2 EPB41L3 CNIH2

2.54e-04198283d81f35c0066558ff96dd06f58fca72cd82e681e8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NEK1 FLRT2 STRA6

2.57e-04199283dfc5c7a4a093baa7158dd8d4d29a870d9c469a3f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Perivascular_fibroblast-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

NEK1 FLRT2 STRA6

2.57e-04199283c1760581c34b81d1d92c67500a1c8944e9cc6dad
ToppCellMacroglial-Astrocytes-SLC14A1|Macroglial / cells hierarchy compared to all cells using T-Statistic

LGR4 FLRT2 GNA14

2.61e-0420028316f468217427921fa18c6d078ffa990eb019b257
ToppCellMacroglial-Astrocytes-SLC14A1-|Macroglial / cells hierarchy compared to all cells using T-Statistic

LGR4 FLRT2 GNA14

2.61e-0420028301819446deeab9054f5cfe889d53bb49d137dbc0
ToppCellMacroglial-Astrocytes-SLC14A1---|Macroglial / cells hierarchy compared to all cells using T-Statistic

LGR4 FLRT2 GNA14

2.61e-04200283d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCellMacroglial-Astrocytes-SLC14A1----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

LGR4 FLRT2 GNA14

2.61e-04200283f861509b54185d89931db64da1b9d81986cc7938
ToppCellMacroglial-Astrocytes-SLC14A1--|Macroglial / cells hierarchy compared to all cells using T-Statistic

LGR4 FLRT2 GNA14

2.61e-042002830442894c39eec69850c090957a5dc7bcecd21e04
Diseaselateral ventricle volume change measurement

EPB41L3 GPR139

8.40e-0515272EFO_0021502
DiseaseDiaphragmatic Hernia

STRA6 CFTR

6.47e-0441272C0019284
Diseaseinsomnia measurement

NAT8 TMEM64 GPR139 CNIH2

6.69e-04443274EFO_0007876
Diseasesusceptibility to common cold measurement

ALG8 SWT1

1.12e-0354272EFO_0008417
Diseaseobsolete aging

MRGPRX3 SNAP91 GPR139

2.07e-03279273GO_0007568
Diseasesnoring measurement

ATP8A1 SNAP91

2.68e-0384272EFO_0008341
Diseasesleep duration

NEK1 EPB41L3 GPR139

4.31e-03362273EFO_0005271
DiseaseCiliopathies

NEK1 CFTR

4.55e-03110272C4277690

Protein segments in the cluster

PeptideGeneStartEntry
HKSLIFVLIWCLVIF

CFTR

856

P13569
VSHSVAKLILVNFHW

ARIH2

86

O95376
SWVVVFKALVTTHHL

SNAP91

71

O60641
VIFVLVVLLSVFCWH

FLRT2

551

O43155
FWVHCLNGLFHSVIL

ATP8A1

941

Q9Y2Q0
KICRHLFHVLAHIYW

MOB2

146

Q70IA6
SIAIFVAILHWLHLV

DPY19L2P1

106

Q6NXN4
LDWFVQICLALKHVH

NEK1

106

Q96PY6
IKHVAWLIFTNCIFF

LGR4

746

Q9BXB1
CFVLHVISWLLIFSI

NRM

141

Q8IXM6
WKVLFCHVHLVSIFL

MRGPRX3

246

Q96LB0
WVFGSLLCKAVHFLI

GALR2

91

O43603
ILSWKFCHVLHKVLR

HIP1R

81

O75146
GVIFFLWHIVSKVLH

ASIC5

126

Q9NY37
HVLIWIHCFTVYLVP

GPR139

181

Q6DWJ6
LWKVCVEHHTFFRLL

EPB41L3

376

Q9Y2J2
KWIHCFESVTSIIFL

GNA14

211

O95837
VIHFCAKQDWLILHI

DAP3

141

P51398
LLHLLQCFKKHWLAV

SWT1

621

Q5T5J6
KHHLWALEVCYISAL

STRA6

356

Q9BX79
HQWCFILFNVILFHA

B3GALT9

11

A8MXE2
FGWHVHEKAILLAIL

ALG8

376

Q9BVK2
LCASLIFFVIWHIIA

CNIH2

16

Q6PI25
TFIAHVVCKRLLTAW

TMEM64

206

Q6YI46
VFLHVASWHFLLGVV

ZDHHC23

101

Q8IYP9
VLCLHLKRFHWTAYL

USP3

406

Q9Y6I4
CHFAHSFIELKVWLL

ZC3H7B

631

Q9UGR2
FCVWARLVALHTVHF

NAT8

201

Q9UHE5