Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	RASGRF1 KALRN FRMD7 THG1L DOCK7 DOCK10 MCF2L FARP2	3.31e-07	231	58	8	GO:0005085
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ARHGDIA RASGRF1 KALRN FRMD7 THG1L DOCK7 DOCK10 MCF2L FARP2	1.44e-05	507	58	9	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ARHGDIA RASGRF1 KALRN FRMD7 THG1L DOCK7 DOCK10 MCF2L FARP2	1.44e-05	507	58	9	GO:0030695
GeneOntologyMolecularFunction	G protein-coupled acetylcholine receptor activity	CHRM3 CHRM5	1.73e-04	7	58	2	GO:0016907
GeneOntologyMolecularFunction	G protein-coupled neurotransmitter receptor activity	CHRM3 CHRM5	6.34e-04	13	58	2	GO:0099528
GeneOntologyMolecularFunction	enzyme regulator activity	ARHGDIA RASGRF1 KALRN DBF4B FRMD7 THG1L DOCK7 DOCK10 MCF2L EIF2AK2 RHEB FARP2	6.57e-04	1418	58	12	GO:0030234
GeneOntologyMolecularFunction	G protein-coupled serotonin receptor activity	CHRM3 CHRM5	1.85e-03	22	58	2	GO:0004993
GeneOntologyMolecularFunction	acetylcholine receptor activity	CHRM3 CHRM5	2.02e-03	23	58	2	GO:0015464
GeneOntologyMolecularFunction	phosphatidylinositol phospholipase C activity	CHRM3 CHRM5	2.58e-03	26	58	2	GO:0004435
GeneOntologyMolecularFunction	phospholipase C activity	CHRM3 CHRM5	3.20e-03	29	58	2	GO:0004629
GeneOntologyBiologicalProcess	small GTPase-mediated signal transduction	ARHGDIA RASGRF1 KALRN FRMD7 DOCK7 DOCK10 MCF2L RHEB FARP2	1.33e-05	538	56	9	GO:0007264
GeneOntologyCellularComponent	somatodendritic compartment	SHANK1 RASGRF1 KALRN FRMD7 DNER DOCK10 MAST1 CHRM3 CHRM5 TRIM3 RIC3 RHEB	1.62e-04	1228	60	12	GO:0036477
GeneOntologyCellularComponent	dendrite	SHANK1 RASGRF1 DNER DOCK10 MAST1 CHRM3 CHRM5 TRIM3 RHEB	7.15e-04	858	60	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	SHANK1 RASGRF1 DNER DOCK10 MAST1 CHRM3 CHRM5 TRIM3 RHEB	7.27e-04	860	60	9	GO:0097447
Domain	FERM-adjacent	FRMD7 EPB41L5 FARP2	7.95e-06	13	58	3	IPR014847
Domain	FA	FRMD7 EPB41L5 FARP2	7.95e-06	13	58	3	SM01195
Domain	FA	FRMD7 EPB41L5 FARP2	7.95e-06	13	58	3	PF08736
Domain	Ez/rad/moesin-like	FRMD7 EPB41L5 FARP2	3.63e-05	21	58	3	IPR000798
Domain	DH_1	RASGRF1 KALRN MCF2L FARP2	4.35e-05	63	58	4	PS00741
Domain	PH_dom-like	RASGRF1 KALRN FRMD7 DOCK10 EPB41L5 SNTG2 MCF2L FARP2	4.84e-05	426	58	8	IPR011993
Domain	FERM_CS	FRMD7 EPB41L5 FARP2	5.49e-05	24	58	3	IPR019747
Domain	DUF1908	MAST4 MAST1	5.66e-05	4	58	2	PF08926
Domain	MA_Ser/Thr_Kinase_dom	MAST4 MAST1	5.66e-05	4	58	2	IPR015022
Domain	MAST_pre-PK_dom	MAST4 MAST1	5.66e-05	4	58	2	IPR023142
Domain	-	MAST4 MAST1	5.66e-05	4	58	2	1.20.1480.20
Domain	RhoGEF	RASGRF1 KALRN MCF2L FARP2	5.88e-05	68	58	4	SM00325
Domain	RhoGEF	RASGRF1 KALRN MCF2L FARP2	6.59e-05	70	58	4	PF00621
Domain	DH_2	RASGRF1 KALRN MCF2L FARP2	6.59e-05	70	58	4	PS50010
Domain	DH-domain	RASGRF1 KALRN MCF2L FARP2	6.97e-05	71	58	4	IPR000219
Domain	-	RASGRF1 KALRN MCF2L FARP2	6.97e-05	71	58	4	1.20.900.10
Domain	FERM_C	FRMD7 EPB41L5 FARP2	7.02e-05	26	58	3	PF09380
Domain	FERM_C	FRMD7 EPB41L5 FARP2	7.88e-05	27	58	3	SM01196
Domain	FERM_PH-like_C	FRMD7 EPB41L5 FARP2	7.88e-05	27	58	3	IPR018980
Domain	Musac_Ach_rcpt	CHRM3 CHRM5	9.42e-05	5	58	2	IPR000995
Domain	DUF3398	DOCK7 DOCK10	1.41e-04	6	58	2	PF11878
Domain	DOCK_C/D_N	DOCK7 DOCK10	1.41e-04	6	58	2	IPR021816
Domain	FERM_N	FRMD7 EPB41L5 FARP2	1.45e-04	33	58	3	PF09379
Domain	FERM_N	FRMD7 EPB41L5 FARP2	1.45e-04	33	58	3	IPR018979
Domain	-	RASGRF1 KALRN FRMD7 DOCK10 EPB41L5 MCF2L FARP2	2.00e-04	391	58	7	2.30.29.30
Domain	PH	RASGRF1 KALRN DOCK10 SNTG2 MCF2L FARP2	2.18e-04	278	58	6	SM00233
Domain	PH_DOMAIN	RASGRF1 KALRN DOCK10 SNTG2 MCF2L FARP2	2.22e-04	279	58	6	PS50003
Domain	PH_domain	RASGRF1 KALRN DOCK10 SNTG2 MCF2L FARP2	2.26e-04	280	58	6	IPR001849
Domain	GDS_CDC24_CS	RASGRF1 MCF2L FARP2	2.40e-04	39	58	3	IPR001331
Domain	FERM_M	FRMD7 EPB41L5 FARP2	3.92e-04	46	58	3	PF00373
Domain	-	FRMD7 EPB41L5 FARP2	4.73e-04	49	58	3	1.20.80.10
Domain	FERM_central	FRMD7 EPB41L5 FARP2	4.73e-04	49	58	3	IPR019748
Domain	FERM_domain	FRMD7 EPB41L5 FARP2	4.73e-04	49	58	3	IPR000299
Domain	FERM_1	FRMD7 EPB41L5 FARP2	5.02e-04	50	58	3	PS00660
Domain	FERM_2	FRMD7 EPB41L5 FARP2	5.02e-04	50	58	3	PS00661
Domain	FERM_3	FRMD7 EPB41L5 FARP2	5.02e-04	50	58	3	PS50057
Domain	Band_41_domain	FRMD7 EPB41L5 FARP2	5.02e-04	50	58	3	IPR019749
Domain	B41	FRMD7 EPB41L5 FARP2	5.02e-04	50	58	3	SM00295
Domain	FERM/acyl-CoA-bd_prot_3-hlx	FRMD7 EPB41L5 FARP2	5.02e-04	50	58	3	IPR014352
Domain	DOCK_C	DOCK7 DOCK10	5.12e-04	11	58	2	IPR010703
Domain	DHR-1_domain	DOCK7 DOCK10	5.12e-04	11	58	2	IPR027007
Domain	DHR_2	DOCK7 DOCK10	5.12e-04	11	58	2	PS51651
Domain	DHR_1	DOCK7 DOCK10	5.12e-04	11	58	2	PS51650
Domain	DOCK-C2	DOCK7 DOCK10	5.12e-04	11	58	2	PF14429
Domain	DHR-2	DOCK7 DOCK10	5.12e-04	11	58	2	IPR027357
Domain	DHR-2	DOCK7 DOCK10	5.12e-04	11	58	2	PF06920
Domain	DOCK	DOCK7 DOCK10	5.12e-04	11	58	2	IPR026791
Domain	PH	RASGRF1 KALRN DOCK10 MCF2L FARP2	7.16e-04	229	58	5	PF00169
Domain	ATPase_dyneun-rel_AAA	MDN1 DNAH2	8.42e-04	14	58	2	IPR011704
Domain	AAA_5	MDN1 DNAH2	8.42e-04	14	58	2	PF07728
Domain	PDZ	SHANK1 MAST4 MAST1 SNTG2	9.63e-04	141	58	4	PF00595
Domain	PDZ	SHANK1 MAST4 MAST1 SNTG2	1.15e-03	148	58	4	SM00228
Domain	-	SHANK1 MAST4 MAST1 SNTG2	1.21e-03	150	58	4	2.30.42.10
Domain	PDZ	SHANK1 MAST4 MAST1 SNTG2	1.24e-03	151	58	4	PS50106
Domain	PDZ	SHANK1 MAST4 MAST1 SNTG2	1.27e-03	152	58	4	IPR001478
Domain	Spectrin	KALRN MCF2L	2.30e-03	23	58	2	PF00435
Domain	SEC14	KALRN MCF2L	2.72e-03	25	58	2	SM00516
Domain	CRAL_TRIO	KALRN MCF2L	3.16e-03	27	58	2	PS50191
Domain	CRAL-TRIO_dom	KALRN MCF2L	3.40e-03	28	58	2	IPR001251
Pathway	PID_CDC42_REG_PATHWAY	ARHGDIA DOCK10 MCF2L FARP2	1.94e-06	30	43	4	M83
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGDIA KALRN DOCK7 DOCK10 MCF2L FARP2	1.40e-05	175	43	6	MM15599
Pathway	REACTOME_RAC1_GTPASE_CYCLE	ARHGDIA KALRN DOCK7 DOCK10 MCF2L FARP2	1.86e-05	184	43	6	M41809
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM3 CHRM5	9.04e-05	5	43	2	M27300
Pathway	REACTOME_MUSCARINIC_ACETYLCHOLINE_RECEPTORS	CHRM3 CHRM5	9.04e-05	5	43	2	MM15006
Pathway	REACTOME_CDC42_GTPASE_CYCLE	ARHGDIA DOCK7 DOCK10 MCF2L	1.87e-04	94	43	4	MM15598
Pathway	PID_RAC1_REG_PATHWAY	ARHGDIA RASGRF1 KALRN	2.07e-04	38	43	3	M241
Pubmed	Calcium mobilization by activation of M(3)/M(5) muscarinic receptors in the human retinoblastoma.	CHRM3 CHRM5	2.93e-06	2	60	2	17951979
Pubmed	Cholinergic responses of ophthalmic arteries in M3 and M5 muscarinic acetylcholine receptor knockout mice.	CHRM3 CHRM5	2.93e-06	2	60	2	19407017
Pubmed	Cigarette smoking promotes inflammation in patients with COPD by affecting the polarization and survival of Th/Tregs through up-regulation of muscarinic receptor 3 and 5 expression.	CHRM3 CHRM5	2.93e-06	2	60	2	25375131
Pubmed	The M(5) muscarinic acetylcholine receptor third intracellular loop regulates receptor function and oligomerization.	CHRM3 CHRM5	2.93e-06	2	60	2	20398705
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	KIAA0319 SHANK1 DNAJC13 MDN1 KALRN TRPC4 DOCK7 EHMT1 TRIM3 RHEB	5.44e-06	963	60	10	28671696
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	INTS6 DCAF6 DNAJC13 SMARCA2 EHMT1 CSTF3 MAST1 SNTG2 TMEM143 MCF2L CHRM3 FARP2	7.54e-06	1489	60	12	28611215
Pubmed	Loss of M5 muscarinic acetylcholine receptors leads to cerebrovascular and neuronal abnormalities and cognitive deficits in mice.	CHRM3 CHRM5	8.77e-06	3	60	2	16956767
Pubmed	M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice.	CHRM3 CHRM5	8.77e-06	3	60	2	15146045
Pubmed	FERM domain containing protein 7 interacts with the Rho GDP dissociation inhibitor and specifically activates Rac1 signaling.	ARHGDIA FRMD7	8.77e-06	3	60	2	23967341
Pubmed	Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.	CHRM3 CHRM5	8.77e-06	3	60	2	1905013
Pubmed	Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.	RASGRF1 ATM	8.77e-06	3	60	2	17611684
Pubmed	Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.	CHRM3 CHRM5	8.77e-06	3	60	2	3272174
Pubmed	M1 receptors mediate cholinergic modulation of excitability in neocortical pyramidal neurons.	CHRM3 CHRM5	8.77e-06	3	60	2	19657040
Pubmed	Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice.	CHRM3 CHRM5	8.77e-06	3	60	2	15691866
Pubmed	Role of M1, M3, and M5 muscarinic acetylcholine receptors in cholinergic dilation of small arteries studied with gene-targeted mice.	CHRM3 CHRM5	8.77e-06	3	60	2	21335473
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RPL10A LHX2 INTS6 DNAJC13 KALRN DOCK7 EHMT1 CSTF3 ATM NKAPL	1.50e-05	1082	60	10	38697112
Pubmed	Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.	CHRM3 CHRM5	1.75e-05	4	60	2	8063729
Pubmed	Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells.	EIF2AK2 CHRM3	1.75e-05	4	60	2	17851256
Pubmed	Ciliary activity in the oviduct of cycling, pregnant, and muscarinic receptor knockout mice.	CHRM3 CHRM5	1.75e-05	4	60	2	22302687
Pubmed	Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C.	CHRM3 CHRM5	1.75e-05	4	60	2	8576254
Pubmed	Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice.	CHRM3 CHRM5	2.92e-05	5	60	2	20940295
Pubmed	Muscarinic acetylcholine receptor subtype 4 is essential for cholinergic stimulation of duodenal bicarbonate secretion in mice - relationship to D cell/somatostatin.	CHRM3 CHRM5	2.92e-05	5	60	2	26084221
Pubmed	Acetylcholine modulates cortical synaptic transmission via different muscarinic receptors, as studied with receptor knockout mice.	CHRM3 CHRM5	2.92e-05	5	60	2	15919709
Pubmed	Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system.	CHRM3 CHRM5	2.92e-05	5	60	2	12675128
Pubmed	Regulation of CD8+ cytolytic T lymphocyte differentiation by a cholinergic pathway.	CHRM3 CHRM5	2.92e-05	5	60	2	15913791
Pubmed	Muscarinic acetylcholine receptor subtypes: localization and structure/function.	CHRM3 CHRM5	2.92e-05	5	60	2	8248499
Pubmed	The M1 muscarinic acetylcholine receptor subtype is important for retinal neuron survival in aging mice.	CHRM3 CHRM5	2.92e-05	5	60	2	30914695
Pubmed	Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice.	CHRM3 CHRM5	2.92e-05	5	60	2	15661360
Pubmed	Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice.	CHRM3 CHRM5	2.92e-05	5	60	2	24695732
Pubmed	Muscarinic receptors in the prenatal mouse embryo. Comparison of M35-immunohistochemistry with [3H]quinuclidinyl benzylate autoradiography.	CHRM3 CHRM5	2.92e-05	5	60	2	7648406
Pubmed	Roles of M2 and M4 muscarinic receptors in regulating acetylcholine release from myenteric neurons of mouse ileum.	CHRM3 CHRM5	2.92e-05	5	60	2	15574798
Pubmed	Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.	CHRM3 CHRM5	2.92e-05	5	60	2	11306684
Pubmed	Multiple muscarinic acetylcholine receptor subtypes modulate striatal dopamine release, as studied with M1-M5 muscarinic receptor knock-out mice.	CHRM3 CHRM5	2.92e-05	5	60	2	12151512
Pubmed	Muscarinic receptors 2 and 5 regulate bitter response of urethral brush cells via negative feedback.	CHRM3 CHRM5	2.92e-05	5	60	2	29401598
Pubmed	Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development.	CHRM3 CHRM5	2.92e-05	5	60	2	19213795
Pubmed	The role of muscarinic receptor subtypes in acetylcholine release from urinary bladder obtained from muscarinic receptor knockout mouse.	CHRM3 CHRM5	2.92e-05	5	60	2	18755247
Pubmed	Muscarinic signaling in the cochlea: presynaptic and postsynaptic effects on efferent feedback and afferent excitability.	CHRM3 CHRM5	2.92e-05	5	60	2	20463237
Pubmed	Distinct muscarinic acetylcholine receptor subtypes contribute to stability and growth, but not compensatory plasticity, of neuromuscular synapses.	CHRM3 CHRM5	2.92e-05	5	60	2	19940190
Pubmed	Association of the proto-oncogene product dbl with G protein betagamma subunits.	KALRN MCF2L	2.92e-05	5	60	2	10518015
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	KIAA0319 MDN1 MAST4 MCF2L	3.23e-05	104	60	4	9205841
Pubmed	Activation of Rac GTPase by p75 is necessary for c-jun N-terminal kinase-mediated apoptosis.	RASGRF1 KALRN MCF2L	3.94e-05	38	60	3	11756498
Pubmed	The Gbeta5-RGS7 complex selectively inhibits muscarinic M3 receptor signaling via the interaction between the third intracellular loop of the receptor and the DEP domain of RGS7.	CHRM3 CHRM5	4.37e-05	6	60	2	19182865
Pubmed	Tracheal brush cells release acetylcholine in response to bitter tastants for paracrine and autocrine signaling.	CHRM3 CHRM5	4.37e-05	6	60	2	31914675
Pubmed	A parasympathetic neurotransmitter induces myoepithelial cell differentiation during salivary gland development.	CHRM3 CHRM5	6.11e-05	7	60	2	35427599
Pubmed	The cell proliferation antigen Ki-67 organises heterochromatin.	RPL10A TICRR DOCK7 SMARCA2 DOCK10 RHEB	7.57e-05	410	60	6	26949251
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	CPA4 RPL10A ARHGDIA DNAJC13 MDN1 SMARCA2 DOCK10 EPB41L5 EIF2AK2 CCDC93	9.84e-05	1353	60	10	29467282
Pubmed	Generation and annotation of the DNA sequences of human chromosomes 2 and 4.	DNER DOCK10 PHOSPHO2 EIF2AK2 CCDC93 FARP2	1.14e-04	442	60	6	15815621
Pubmed	Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.	CHRM3 CHRM5	1.31e-04	10	60	2	10336173
Pubmed	BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.	SHANK1 BPIFB4 NCKAP5	1.34e-04	57	60	3	27433848
Pubmed	Rheb binds and regulates the mTOR kinase.	ATM RHEB	1.91e-04	12	60	2	15854902
Pubmed	An ATM/TRIM37/NEMO Axis Counteracts Genotoxicity by Activating Nuclear-to-Cytoplasmic NF-κB Signaling.	DOCK7 ATM	2.26e-04	13	60	2	30254148
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	RPL10A SHANK1 OR7G1 EPB41L5 L3HYPDH CHRM3	2.55e-04	513	60	6	25798074
Pubmed	Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.	DOCK7 DOCK10	2.63e-04	14	60	2	12432077
Pubmed	An LRP16-containing preassembly complex contributes to NF-κB activation induced by DNA double-strand breaks.	CSTF3 EIF2AK2	3.03e-04	15	60	2	25735744
Pubmed	PDZ-Containing Proteins Targeted by the ACE2 Receptor.	SHANK1 MAST1	3.03e-04	15	60	2	34835087
Pubmed	Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.	MDN1 SMARCA2	3.03e-04	15	60	2	19762545
Pubmed	Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS.	RPL10A DNAJC13 MDN1 SMARCA2 CSTF3	3.05e-04	340	60	5	29478914
Pubmed	Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32.	MAST4 CHRM3	3.91e-04	17	60	2	22949513
Pubmed	Identification and subclassification of new Atoh1 derived cell populations during mouse spinal cord development.	LHX2 SMARCA2	3.91e-04	17	60	2	19135992
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	CHRM3 CHRM5	3.91e-04	17	60	2	10549128
Pubmed	Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.	MCF2L FARP2	4.40e-04	18	60	2	12799088
Pubmed	Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons.	LHX2 TBX5	4.40e-04	18	60	2	20503368
Pubmed	No evidence for association between 19 cholinergic genes and bipolar disorder.	CHRM3 CHRM5	4.91e-04	19	60	2	17373692
Pubmed	Neuroretina specification in mouse embryos requires Six3-mediated suppression of Wnt8b in the anterior neural plate.	LHX2 TBX5	4.91e-04	19	60	2	20890044
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	INTS6 DNAJC13 MDN1 SMARCA2 CSTF3 ATM	4.98e-04	582	60	6	20467437
Pubmed	The transcription factor Maz is essential for normal eye development.	LHX2 TBX5	6.02e-04	21	60	2	32571845
Pubmed	Optic vesicle morphogenesis requires primary cilia.	LHX2 TBX5	6.02e-04	21	60	2	32169553
Pubmed	A library of 7TM receptor C-terminal tails. Interactions with the proposed post-endocytic sorting proteins ERM-binding phosphoprotein 50 (EBP50), N-ethylmaleimide-sensitive factor (NSF), sorting nexin 1 (SNX1), and G protein-coupled receptor-associated sorting protein (GASP).	CHRM3 CHRM5	6.02e-04	21	60	2	15452121
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	DOCK10 EHMT1 DSCAML1 TPCN1	6.26e-04	225	60	4	12168954
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KIAA0319 DOCK7 DOCK10 MAST1 MCF2L	6.90e-04	407	60	5	12693553
Pubmed	Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks.	RPL10A INTS6 EHMT1	7.42e-04	102	60	3	26584622
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	MDN1 EPB41L5 ATM	7.85e-04	104	60	3	31240132
Pubmed	The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.	LHX2 KALRN	7.88e-04	24	60	2	35179492
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	MDN1 DNAH2 SMARCA2 EHMT1 MCF2L RHEB	8.04e-04	638	60	6	31182584
Pubmed	Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment.	DBF4B CSTF3	8.56e-04	25	60	2	15782160
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	RPL10A ARHGDIA MDN1 DOCK7 SMARCA2 ATM	9.07e-04	653	60	6	22586326
Pubmed	Transcriptional profiling of sequentially generated septal neuron fates.	TRPC4 DNER	9.26e-04	26	60	2	34851821
Pubmed	Histone H3 lysine 9 methyltransferases, G9a and GLP are essential for cardiac morphogenesis.	CPA4 EHMT1	9.26e-04	26	60	2	23892084
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	ATM RHEB	9.99e-04	27	60	2	23027611
Pubmed	Canonical Wnt/β-catenin signalling is essential for optic cup formation.	LHX2 TBX5	1.15e-03	29	60	2	24324671
Pubmed	Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.	LHX2 TBX5	1.15e-03	29	60	2	19906857
Pubmed	Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.	LHX2 ATM	1.23e-03	30	60	2	37048108
Pubmed	The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition.	CSTF3 NCKAP5 EIF2AK2 TRIM3	1.43e-03	281	60	4	24163370
Pubmed	Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication.	LHX2 TBX5	1.49e-03	33	60	2	24705356
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	SHANK1 DCAF6 KALRN DNER MAST1 NCKAP5 ATM DSCAML1	1.58e-03	1285	60	8	35914814
Pubmed	Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation.	MAST1 SNTG2	1.58e-03	34	60	2	30726710
Pubmed	Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.	IL1RN FARP2	1.68e-03	35	60	2	23969696
Cytoband	2q14.2	EPB41L5 IL1RN	3.14e-04	20	60	2	2q14.2
Cytoband	Ensembl 112 genes in cytogenetic band chr2q14	EPB41L5 IL1RN CCDC93	1.34e-03	165	60	3	chr2q14
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 KALRN MCF2L FARP2	1.48e-05	66	41	4	722
GeneFamily	Cholinergic receptors muscarinic	CHRM3 CHRM5	5.00e-05	5	41	2	180
GeneFamily	Ankyrin repeat domain containing\|FERM domain containing	FRMD7 EPB41L5 FARP2	1.97e-04	50	41	3	1293
GeneFamily	PDZ domain containing	SHANK1 MAST4 MAST1 SNTG2	3.82e-04	152	41	4	1220
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 DOCK10 MCF2L FARP2	1.19e-03	206	41	4	682
CoexpressionAtlas	FacebaseRNAseq_e9.5_Olfactory Placode_top-relative-expression-ranked_1000_k-means-cluster#2	SHANK1 LHX2 EPB41L5 MAST1 NCKAP5 MCF2L RIC3	1.85e-06	210	59	7	Facebase_RNAseq_e9.5_Olfactory Placode_1000_K2
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_top-relative-expression-ranked_1000_k-means-cluster#4	LHX2 EPB41L5 MAST1 NCKAP5 MCF2L RIC3	3.73e-05	225	59	6	Facebase_RNAseq_e10.5_Neural Epithelium Overlying Medial Eminence_1000_K4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 SULT2B1 SNTG2 MCF2L DSCAML1	5.76e-06	190	60	5	1cf023e3c6924d6a06f353d4b62444b6f2fee8a7
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_ascending_limb_epithelial_cell-Ascending_Thin_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 SULT2B1 SNTG2 MCF2L DSCAML1	5.76e-06	190	60	5	59bbbd2c8d4b7ce46c54ca8022b1557e7e5eee2a
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 RASGRF1 FOXO4 NPAS4	5.83e-05	156	60	4	5caefdc6cc86f2ac52abe8c8da821db14f476915
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SMIM27 FBXO4 KALRN BBOF1	5.83e-05	156	60	4	84f01419d8c116714e8c8c857c4d153a755b7867
ToppCell	facs-Marrow-T_cells-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DCAF6 RASGRF1 FOXO4 NPAS4	5.83e-05	156	60	4	758f57dc10fc5cad200bf5b310c10ec9b1405f23
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD4+_T-Treg-Treg_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SMIM27 FBXO4 KALRN BBOF1	5.83e-05	156	60	4	2285be9746d0d0f62a488b9c64fa67a834758dd7
ToppCell	3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	RPL10A SULT2B1 BPIFB4 RIC3	6.43e-05	160	60	4	445cef1f2f3279672620664792d4eec54df71bdb
ToppCell	Endothelial-endothelial_cell_of_bronchial_vessel\|World / Lineage, Cell type, age group and donor	KALRN SNTG2 MCF2L CHRM3	7.25e-05	165	60	4	84e553d699ac56df89a77248f7308b9133e1b683
ToppCell	control-Epithelial-Ionocyte\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAST1 NCKAP5 MCF2L CHRM3	7.25e-05	165	60	4	5cfba9a46bd8ceeca74a6493057b4d38af6b06fe
ToppCell	control-Epithelial-Ionocyte\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MAST1 NCKAP5 MCF2L CHRM3	7.77e-05	168	60	4	327b02f19f4a8607c033203824fdc60a1254331f
ToppCell	PND07-Immune-Immune_Myeloid-Monocytic-Macrophage-AM-AM_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	DNAJC13 PCLAF DOCK10 IL1RN	8.32e-05	171	60	4	845f312f8cbe29d820da25f0e6d75deb382bbfd8
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	KALRN DOCK10 CHRM3 NPAS4	8.32e-05	171	60	4	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LHX2 TICRR FOXO4 TRIM3	8.51e-05	172	60	4	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|368C / Donor, Lineage, Cell class and subclass (all cells)	KIAA0319 SULT2B1 PCLAF CHRM3	9.10e-05	175	60	4	fd8b5b756f3df4a04938785f3d9edbb6f1cd20f6
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|368C / Donor, Lineage, Cell class and subclass (all cells)	KIAA0319 SULT2B1 PCLAF CHRM3	9.10e-05	175	60	4	36c140540497bbe1c5f08fac2d94f08cac18fabb
ToppCell	390C-Lymphocytic-NK_cells-Proliferating_NK_cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	TICRR PCLAF IL1RN TBX5	9.30e-05	176	60	4	8813c01ea080f373fe3970c5e1ba4c2dca0f7f02
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 INTS6 PCLAF DNAH2	9.72e-05	178	60	4	6178706db4a855d72abc156537604d575624df56
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 INTS6 PCLAF DNAH2	9.72e-05	178	60	4	f02076ece0fa899e620971c887ad4da7f48684ed
ToppCell	390C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	TICRR PCLAF IL1RN TBX5	9.93e-05	179	60	4	e67ad7ab04d0c1309296f57c1f53c5ca14c213fe
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(other)\|COVID-19 / group, cell type (main and fine annotations)	KALRN SNTG2 MCF2L CHRM3	1.04e-04	181	60	4	26eb4ee57a70dbf54e096b73129fda9dfda1f6ec
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 NCKAP5 MCF2L TPCN1	1.08e-04	183	60	4	facd6dbe0851b537d70a899ac7485714ab27d071
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 NCKAP5 MCF2L TPCN1	1.08e-04	183	60	4	84b64cf728629c3af9a8d2ed15b93adf562c54b8
ToppCell	3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KIAA0319 DNER DNAH2 BBOF1	1.08e-04	183	60	4	58847e8f3a7ce3e33adba9477bcd55e769a64a90
ToppCell	10x_3'_v2v3-Neoplastic-Stem-like-NPC-like-NPC-like_OPC-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LHX2 DNER NKAPL RIC3	1.08e-04	183	60	4	8c8ce5a0d5535bef58ac10b7eb726f9c50af2ed8
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 NCKAP5 MCF2L TPCN1	1.17e-04	187	60	4	dcf6475ece5b34d9d58a0d1f51c18acedb19c119
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	MAST4 NCKAP5 MCF2L TPCN1	1.17e-04	187	60	4	f1356273bd3587b6883295edf15cb9cdb706c057
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SULT2B1 SNTG2 MCF2L DSCAML1	1.17e-04	187	60	4	c41a2c81dd2ceef303f39f699032aa7d6ea67cf0
ToppCell	LA-13._Vascular_Smooth_Muscle\|LA / Chamber and Cluster_Paper	KALRN TRPC4 DOCK10 CHRM3	1.20e-04	188	60	4	34e1b074a3995aa46ab194eb45115d76d1a5514d
ToppCell	LA-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	KALRN TRPC4 DOCK10 CHRM3	1.22e-04	189	60	4	6b3e88751b95fc2173f2c3d5061ed632d0c5f01c
ToppCell	Hippocampus-Neuronal-Excitatory\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DCAF6 RASGRF1 SULT2B1 KALRN	1.22e-04	189	60	4	4b90d181eb0a42814eeb23bc82e52fd3a12392a7
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPL10A ATM EIF2AK2 RIC3	1.33e-04	193	60	4	2901d7a9672a8cf70c9f1c752685b45e4d79ac70
ToppCell	3'_v3-bone_marrow-Lymphocytic_T_CD8-Tnaive/CM_CD8\|bone_marrow / Manually curated celltypes from each tissue	RPL10A SNTG2 ATM RIC3	1.33e-04	193	60	4	8eee202253f73342b5f5bfdc094435180970424a
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 RASGRF1 KALRN CHRM3	1.33e-04	193	60	4	461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 RASGRF1 KALRN CHRM3	1.33e-04	193	60	4	0dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD4+_T_activated\|COVID-19_Severe / Disease group, lineage and cell class	RPL10A ATM EIF2AK2 RIC3	1.33e-04	193	60	4	beb862d38b88572836b0a797c8efef7a2492e0b9
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPL10A ATM EIF2AK2 RIC3	1.33e-04	193	60	4	f4310faa13fc8ce99a217e2d1c9cc733683797a1
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RPL10A ATM EIF2AK2 RIC3	1.33e-04	193	60	4	f8af695457d2a0a911a5ac491742465864ebda37
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD4+_T-CD4+_T_activated\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RPL10A ATM EIF2AK2 RIC3	1.33e-04	193	60	4	089aece40130034a89a5213be778f10b0787eeba
ToppCell	COVID-19_Severe-CD8+_T_naive\|COVID-19_Severe / Disease condition and Cell class	RPL10A SNTG2 ATM RIC3	1.33e-04	193	60	4	8ece109352d67b6a76bc87a2579e299c77c63137
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPL10A SNTG2 ATM RIC3	1.35e-04	194	60	4	7c80fd2a70ee737d52738db6ad58577a15677fc4
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RPL10A SNTG2 ATM RIC3	1.35e-04	194	60	4	1154625adeafa354d8cc847e26b75f4f37e4c39f
ToppCell	COVID-19_Severe-Lymphoid_T/NK-CD8+_T_naive\|COVID-19_Severe / Disease group, lineage and cell class	RPL10A SNTG2 ATM RIC3	1.35e-04	194	60	4	6aeedfdb2b526913937eea978ddcbab8be4e49a6
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RPL10A SNTG2 ATM RIC3	1.35e-04	194	60	4	a1fabd408a74c2649a69e57e8865b79fdfe9047f
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	RPL10A SNTG2 ATM RIC3	1.35e-04	194	60	4	3844ef71804feef04948ff82fec4244e88fb63b2
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT1\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	KIAA0319 SULT2B1 EPB41L5 NCKAP5	1.38e-04	195	60	4	a71ba5e4043e2d35a45a2c60a96b087e31832345
ToppCell	facs-Brain_Non-Myeloid-Cortex-3m-Neuronal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KIAA0319 RASGRF1 KALRN CHRM3	1.38e-04	195	60	4	ffbab350e67d9c4b66c0ab84550daec8b8139a27
ToppCell	COVID-19_Severe-CD4+_T_activated\|World / disease group, cell group and cell class	RPL10A SNTG2 EIF2AK2 RIC3	1.38e-04	195	60	4	61d2d6c2d59799b3d877e622ccbcee9e84703a35
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SNTG2 NCKAP5 MCF2L CHRM3	1.44e-04	197	60	4	6a3c647af41fea923311562575a0d656fbc13cbe
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_A-Branch_A1_(iMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DNER MAST1 TMC3 RIC3	1.46e-04	198	60	4	b58138581f1a9073267d64c1211c5b9b4de71d3e
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD8+_T_naive\|COVID-19_Severe / Disease, condition lineage and cell class	RPL10A SNTG2 ATM RIC3	1.49e-04	199	60	4	4fffd7b7355f8c56892e8e2d75f55f77b4e1bcc6
ToppCell	severe-CD8+_T_naive\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RPL10A SNTG2 ATM RIC3	1.49e-04	199	60	4	656e639228b3f2dca6955a487e4999e73a69bc51
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Severe / Disease, condition lineage and cell class	RPL10A ATM EIF2AK2 RIC3	1.52e-04	200	60	4	deeed668b129e66156b5f6abe1a07a9bf842a14d
Drug	Indapamide [26807-65-8]; Up 200; 10.6uM; PC3; HT_HG-U133A	MAST4 KALRN MCF2L IL1RN TRIM3 FARP2	1.36e-05	198	60	6	3778_UP
Drug	Tolazoline hydrochloride [59-97-2]; Up 200; 20.4uM; PC3; HT_HG-U133A	KALRN TRPC4 EHMT1 IL1RN TRIM3 RIC3	1.40e-05	199	60	6	4262_UP
Drug	Riboflavine [83-88-5]; Up 200; 10.6uM; PC3; HT_HG-U133A	LHX2 KALRN EHMT1 EPB41L5 FOXO4 TRIM3	1.40e-05	199	60	6	4485_UP
Drug	Botiacrine	CHRM3 CHRM5	4.08e-05	4	60	2	CID000071202
Drug	diphenhydramine	PCLAF ATM CHRM3 CHRM5	4.60e-05	75	60	4	CID000003100
Drug	Atropine	CHRM3 CHRM5	6.79e-05	5	60	2	DB00572
Drug	Fesoterodine	CHRM3 CHRM5	6.79e-05	5	60	2	DB06702
Drug	Darifenacin	CHRM3 CHRM5	6.79e-05	5	60	2	DB00496
Drug	Metixene	CHRM3 CHRM5	6.79e-05	5	60	2	DB00340
Drug	Trihexyphenidyl	CHRM3 CHRM5	6.79e-05	5	60	2	DB00376
Drug	Solifenacin	CHRM3 CHRM5	6.79e-05	5	60	2	DB01591
Drug	5-(3-(3-hydroxyphenoxy)azetidin-1-yl)-5-methyl-2,2-diphenylhexanamide	CHRM3 CHRM5	6.79e-05	5	60	2	ctd:C568516
Drug	Pipecuronium	CHRM3 CHRM5	6.79e-05	5	60	2	ctd:D017300
Drug	N-Methylscopolamine	CHRM3 CHRM5	6.79e-05	5	60	2	ctd:D019832
Drug	eucatropine	CHRM3 CHRM5	6.79e-05	5	60	2	CID000007534
Drug	Tolterodine	CHRM3 CHRM5	6.79e-05	5	60	2	DB01036
Drug	Cryptenamine	CHRM3 CHRM5	6.79e-05	5	60	2	DB00785
Drug	Homatropine Methylbromide	CHRM3 CHRM5	6.79e-05	5	60	2	DB00725
Drug	Quinuclidinyl Benzilate	CHRM3 CHRM5	6.79e-05	5	60	2	ctd:D011813
Drug	Nsc34399	CHRM3 CHRM5	1.02e-04	6	60	2	CID000003622
Drug	Gallamine Triethiodide	CHRM3 CHRM5	1.02e-04	6	60	2	ctd:D005703
Drug	Dactil	CHRM3 CHRM5	1.02e-04	6	60	2	CID000004839
Drug	N-PAB	PCLAF FARP2	1.02e-04	6	60	2	CID000115256
Drug	4-diphenylacetoxy-1,1-dimethylpiperidinium	CHRM3 CHRM5	1.02e-04	6	60	2	ctd:C042375
Drug	brucine N-oxide	CHRM3 CHRM5	1.02e-04	6	60	2	ctd:C083067
Drug	Brompheniramine	CHRM3 CHRM5	1.02e-04	6	60	2	DB00835
Drug	Benzquinamide	CHRM3 CHRM5	1.02e-04	6	60	2	DB00767
Drug	Scopolamine	CHRM3 CHRM5	1.02e-04	6	60	2	DB00747
Drug	Crotalid Venoms	CHRM3 CHRM5	1.02e-04	6	60	2	ctd:D003435
Drug	Tiotropium Bromide	CHRM3 CHRM5	1.42e-04	7	60	2	ctd:D000069447
Drug	Testosterone propionate [57-85-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	DOCK10 EHMT1 EPB41L5 ATM TRIM3	1.45e-04	190	60	5	5271_DN
Drug	Clomipramine hydrochloride [17321-77-6]; Up 200; 11.4uM; PC3; HT_HG-U133A	RASGRF1 TRPC4 IL1RN TRIM3 TIGD6	1.48e-04	191	60	5	4487_UP
Drug	radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA	LHX2 MAST4 CSTF3 ATM CCDC93	1.48e-04	191	60	5	1057_DN
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A	LHX2 RASGRF1 KALRN EPB41L5 IL1RN	1.48e-04	191	60	5	3058_UP
Drug	lomustine; Down 200; 100uM; MCF7; HT_HG-U133A	LHX2 SULT2B1 EPB41L5 TRIM3 TBX5	1.48e-04	191	60	5	7045_DN
Drug	Prednisolone [50-24-8]; Up 200; 11uM; PC3; HT_HG-U133A	MAST4 DOCK10 EHMT1 FOXO4 TRIM3	1.52e-04	192	60	5	5101_UP
Drug	AC1NUW4G	IL1RN CHRM3 CHRM5	1.60e-04	40	60	3	CID005462134
Drug	Hydrastine hydrochloride [5936-28-7]; Up 200; 9.6uM; PC3; HT_HG-U133A	MAST4 SMARCA2 EPB41L5 IL1RN FARP2	1.63e-04	195	60	5	7309_UP
Drug	CAY10397; Up 200; 10uM; PC3; HT_HG-U133A	MAST4 SULT2B1 DBF4B ATM BBOF1	1.63e-04	195	60	5	7087_UP
Drug	3-alpha-Hydroxy-5-beta-androstan-17-one [53-42-9]; Up 200; 13.8uM; PC3; HT_HG-U133A	MAST4 EPB41L5 MCF2L IL1RN TRIM3	1.63e-04	195	60	5	4298_UP
Drug	Apigenin [520-36-5]; Up 200; 14.8uM; PC3; HT_HG-U133A	SHANK1 RASGRF1 TRPC4 CSTF3 IL1RN	1.67e-04	196	60	5	4578_UP
Drug	Edrophonium chloride [116-38-1]; Up 200; 19.8uM; PC3; HT_HG-U133A	DBF4B DOCK10 EHMT1 ATM TBX5	1.67e-04	196	60	5	6655_UP
Drug	Calycanthine [595-05-1]; Down 200; 11.6uM; MCF7; HT_HG-U133A	MAST4 SMARCA2 ATM CHRM3 TPCN1	1.67e-04	196	60	5	2764_DN
Drug	Diloxanide furoate [3736-81-0]; Up 200; 12.2uM; PC3; HT_HG-U133A	KALRN IL1RN CHRM5 TRIM3 TBX5	1.71e-04	197	60	5	6679_UP
Drug	Methyldopate hydrochloride [2508-79-4]; Up 200; 14.6uM; MCF7; HT_HG-U133A	KALRN SMARCA2 IL1RN TRIM3 TIGD6	1.71e-04	197	60	5	7360_UP
Drug	Prednisone [53-03-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	EHMT1 EPB41L5 MCF2L TRIM3 TIGD6	1.71e-04	197	60	5	4577_DN
Drug	Boldine [476-70-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	LHX2 MAST4 SULT2B1 MCF2L CHRM3	1.71e-04	197	60	5	2804_DN
Drug	Cefazolin sodium salt [27164-46-1]; Up 200; 8.4uM; PC3; HT_HG-U133A	SHANK1 FOXO4 IL1RN TRIM3 TBX5	1.71e-04	197	60	5	3686_UP
Drug	Saphris	IL1RN CHRM3 CHRM5	1.73e-04	41	60	3	CID000163091
Drug	Chloroquine diphosphate [50-63-5]; Down 200; 7.8uM; PC3; HT_HG-U133A	MAST4 DBF4B TIGD6 TPCN1 BBOF1	1.75e-04	198	60	5	7251_DN
Drug	Cyproterone acetate [427-51-0]; Up 200; 9.6uM; PC3; HT_HG-U133A	MAST4 TRPC4 MCF2L IL1RN RIC3	1.75e-04	198	60	5	4470_UP
Drug	celecoxib; Up 200; 10uM; MCF7; HG-U133A	ATM IL1RN RIC3 BBOF1 FARP2	1.75e-04	198	60	5	206_UP
Drug	Orphenadrine hydrochloride [341-69-5]; Down 200; 13uM; MCF7; HT_HG-U133A	LHX2 MAST4 CHRM3 TPCN1 FARP2	1.75e-04	198	60	5	3883_DN
Drug	(-)-MK 801 hydrogen maleate [77086-19-2]; Up 200; 11.8uM; PC3; HT_HG-U133A	RASGRF1 DBF4B DOCK10 FOXO4 MCF2L	1.75e-04	198	60	5	6657_UP
Drug	0317956-0000 [391210-11-0]; Up 200; 1uM; PC3; HT_HG-U133A	KALRN DOCK10 MCF2L IL1RN TRIM3	1.79e-04	199	60	5	3777_UP
Drug	Graveoline [485-61-0]; Down 200; 14.4uM; MCF7; HT_HG-U133A	MAST4 EHMT1 CHRM3 TRIM3 CCDC93	1.84e-04	200	60	5	6034_DN
Drug	secoverine	CHRM3 CHRM5	1.89e-04	8	60	2	CID000042470
Drug	Maprotiline	CHRM3 CHRM5	1.89e-04	8	60	2	DB00934
Drug	Boehmite (Al(OH)O	DNER FARP2	1.89e-04	8	60	2	CID000073982
Drug	Paroxetine	CHRM3 CHRM5	1.89e-04	8	60	2	DB00715
Drug	darifenicin	IL1RN CHRM3 CHRM5	1.99e-04	43	60	3	CID000072054
Drug	dimethyl L-glutamate	DNER EHMT1	2.43e-04	9	60	2	CID000093032
Drug	Rilapinum	CHRM3 CHRM5	2.43e-04	9	60	2	CID006446980
Drug	Trest	CHRM3 CHRM5	2.43e-04	9	60	2	CID000004167
Drug	NSC4828	PCLAF FARP2	2.43e-04	9	60	2	CID000221063
Drug	sila-hexocyclium	CHRM3 CHRM5	2.43e-04	9	60	2	CID000130169
Drug	Promethazine	CHRM3 CHRM5	3.03e-04	10	60	2	DB01069
Drug	tenilapine	CHRM3 CHRM5	3.03e-04	10	60	2	CID006450478
Disease	parenchymal hematoma, response to recombinant tissue-plasminogen activator	SNTG2 DSCAML1	5.47e-05	6	57	2	EFO_0020101, EFO_0600080
Disease	female breast cancer (is_implicated_in)	MAST1 ATM	1.02e-04	8	57	2	DOID:0050671 (is_implicated_in)
Disease	Fibrosis	THG1L ATM IL1RN	1.26e-04	50	57	3	C0016059
Disease	Cirrhosis	THG1L ATM IL1RN	1.26e-04	50	57	3	C1623038
Disease	response to 5-fluorouracil, response to cyclophosphamide, chemotherapy-induced alopecia, response to doxorubicin	LHX2 SMARCA2	3.29e-04	14	57	2	EFO_0005400, GO_0036275, GO_1902518, GO_1902520
Disease	Colorectal Carcinoma	SHANK1 SULT2B1 KALRN DSCAML1 CCDC93 RIC3 RHEB	3.94e-04	702	57	7	C0009402
Disease	pulmonary fibrosis (is_implicated_in)	IL1RN CHRM3	4.32e-04	16	57	2	DOID:3770 (is_implicated_in)
Disease	Parkinson's disease (is_implicated_in)	DNAJC13 ATM EIF2AK2	4.35e-04	76	57	3	DOID:14330 (is_implicated_in)
Disease	RS-10-hydroxywarfarin measurement	FBXO4 KALRN DSCAML1	9.13e-04	98	57	3	EFO_0803330
Disease	obsolete_red blood cell distribution width	DNAJC13 MAST4 KALRN THG1L SMARCA2 MAST1 IL1RN EIF2AK2 BBOF1	1.04e-03	1347	57	9	EFO_0005192
Disease	proteinuria (implicated_via_orthology)	EPB41L5 NCKAP5	1.54e-03	30	57	2	DOID:576 (implicated_via_orthology)
Disease	Autistic Disorder	SHANK1 SNTG2 IL1RN FARP2	1.64e-03	261	57	4	C0004352

Protein segments in the cluster

Peptide	Gene	Start	Entry
AKVRLTMDRTGYPRL	BPIFB4	276	P59827
RRASKSSRPMYGAVT	FBXO4	151	Q9UKT5
YRAKRTTKRAGVMIG	CHRM3	176	P20309
RPLVKMVYKGHRNSR	DCAF6	706	Q58WW2
LKMRAACTGRTEYPK	BBOF1	391	Q8ND07
MKLRARDPASRGDRY	INTS6	36	Q9UL03
SDANPVRYGRRRMKL	MDN1	131	Q9NU22
YGKEIRSPMARIRLS	FRMD7	666	Q6ZUT3
KSGKAPRRRAASMDS	FOXO4	186	P98177
YMKFARRAEGIKSGR	CSTF3	381	Q12996
RKGSLTPGYMFKRSI	KALRN	2161	O60229
RDQPYPSSQKTKRMR	LHX2	256	P50458
TDKAYTGSMLRKRNP	RIC3	351	Q7Z5B4
AMPRKGYTLQKTLSR	PHOSPHO2	196	Q8TCD6
IGPARRSSYKAKMAR	MAST1	1061	Q9Y2H9
MVRTKADSVPGTYRK	PCLAF	1	Q15004
LRMPSARGKYKAFST	OR7G1	226	Q8NGA0
MPQSKSRKIAILGYR	RHEB	1	Q15382
MYRSTKGASKARRDQ	NPAS4	1	Q8IUM7
AVVDYMRRQKRPSSG	ATM	1911	Q13315
GRRYGFSRQSKMEKA	CCDC93	206	Q567U6
PSKRYSRRTLQMKAC	EPB41L5	371	Q9HCM4
YRRADRISKMQTIPG	DOCK10	601	Q96BY6
YKFLADMRRPSSVLR	DOCK7	486	Q96N67
RLYRDTGLVKMSRKP	CSAG1	26	Q6PB30
PKGMLARGSYSIKSR	ARHGDIA	166	P52565
NDGKRTRSKGTLRYM	EIF2AK2	441	P19525
PRSAAHTMPRRKKGY	DBF4B	286	Q8NFT6
RMYSFNKIGRSEPSK	DSCAML1	961	Q8TD84
RPMYVLKFSTGKGVR	CPA4	156	Q9UI42
ISRIPRGAFERKMSY	NDUFAF1	186	Q9Y375
RKSLAGMLTPYVARK	DNAJC13	1606	O75165
RGPYRRAKSEMSESR	MCF2L	601	O15068
GPARRNSYKSRMVRR	MAST4	1236	O15021
RPSGRKSSKMQAFRI	IL1RN	26	P18510
KDSGMKRIPYERRHS	FARP2	356	O94887
SIRHARFGKKSRPAM	DNER	696	Q8NFT8
RPAESRKKSAKGMYS	DNAH2	4366	Q9P225
SRKKKRRMGTYSLVP	EHMT1	286	Q9H9B1
ASVGPQRKRMRSALY	TIGD6	61	Q17RP2
MKTSKASQRYRGIRR	TMC3	1	Q7Z5M5
FSSKAKVIYMGRNPR	SULT2B1	136	O00204
KISYKGTPAMRRSLV	SMARCA2	801	P51531
RRMFPSYKVKVTGLN	TBX5	81	Q99593
GFRKSRLPALSSRKM	NCKAP5	1511	O14513
ASMVSARRQLRKKYP	SMIM27	31	A0A1B0GUW7
SVPLSMARISRYKAG	SNTG2	221	Q9NY99
GTPNKEKYRRMSLAS	RASGRF1	916	Q13972
EVSGPTLLAKRRYMR	L3HYPDH	41	Q96EM0
RRRKLYSAVPGRSFM	SHANK1	546	Q9Y566
LTYRAKRTPKRAGIM	CHRM5	136	P08912
AAMAEYVKAGKRIPR	NKAPL	306	Q5M9Q1
RPISRTYTRKKLMGT	TICRR	1891	Q7Z2Z1
PRALSSLAAKMGEYR	TMEM143	41	Q96AN5
RRYLRLGATMAKSKF	THG1L	21	Q9NWX6
VRALYIKSTMGKPQR	RPL10A	201	P62906
KPRMSARERYLTFKA	TPCN1	371	Q9ULQ1
KMRRKPESFGTIGRR	TRPC4	681	Q9UBN4
RRPSSMYSTGGKRKD	TRIM3	451	O75382
RMELRPKYGIKHRST	KIAA0319	1006	Q5VV43