Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	manganese ion binding	ADCY10 MGAT5 PCK1	2.38e-04	71	34	3	GO:0030145
GeneOntologyMolecularFunction	adenylate cyclase activity	ADCY10 ADCY6	4.23e-04	18	34	2	GO:0004016
GeneOntologyMolecularFunction	lyase activity	ADCY10 KYAT3 ADCY6 PCK1	4.46e-04	212	34	4	GO:0016829
GeneOntologyMolecularFunction	cyclase activity	ADCY10 ADCY6	7.59e-04	24	34	2	GO:0009975
GeneOntologyMolecularFunction	magnesium ion binding	STK38 ADCY10 STK38L PCK1	7.92e-04	247	34	4	GO:0000287
GeneOntologyMolecularFunction	phosphorus-oxygen lyase activity	ADCY10 ADCY6	8.24e-04	25	34	2	GO:0016849
Domain	Nucleotide_cyclase	ADCY10 ADCY6	4.55e-04	18	33	2	IPR029787
Domain	-	ADCY10 ADCY6	4.55e-04	18	33	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_2	ADCY10 ADCY6	5.08e-04	19	33	2	PS50125
Domain	GUANYLATE_CYCLASE_1	ADCY10 ADCY6	5.08e-04	19	33	2	PS00452
Domain	A/G_cyclase	ADCY10 ADCY6	5.08e-04	19	33	2	IPR001054
Domain	CYCc	ADCY10 ADCY6	5.08e-04	19	33	2	SM00044
Domain	Guanylate_cyc	ADCY10 ADCY6	5.08e-04	19	33	2	PF00211
Domain	Pkinase_C	STK38 STK38L	1.94e-03	37	33	2	IPR017892
Domain	Pkinase_C	STK38 STK38L	2.49e-03	42	33	2	PF00433
Domain	AGC-kinase_C	STK38 STK38L	4.39e-03	56	33	2	IPR000961
Domain	AGC_KINASE_CTER	STK38 STK38L	4.39e-03	56	33	2	PS51285
Domain	S_TK_X	STK38 STK38L	4.39e-03	56	33	2	SM00133
Domain	Olfact_rcpt	OR2T10 OR4S2 OR4C16 OR51M1	4.88e-03	393	33	4	IPR000725
Pubmed	NDR functions as a physiological YAP1 kinase in the intestinal epithelium.	STK38 STK38L	9.28e-07	2	34	2	25601544
Pubmed	Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein.	STK38 STK38L	9.28e-07	2	34	2	15037617
Pubmed	Cyclin D1 promotes cell cycle progression through enhancing NDR1/2 kinase activity independent of cyclin-dependent kinase 4.	STK38 STK38L	2.78e-06	3	34	2	23897809
Pubmed	Human NDR kinases control G(1)/S cell cycle transition by directly regulating p21 stability.	STK38 STK38L	2.78e-06	3	34	2	21262772
Pubmed	HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases.	STK38 STK38L	2.78e-06	3	34	2	15582665
Pubmed	NDR kinase is activated by RASSF1A/MST1 in response to Fas receptor stimulation and promotes apoptosis.	STK38 STK38L	5.56e-06	4	34	2	19062280
Pubmed	Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein.	STK38 STK38L	5.56e-06	4	34	2	15197186
Pubmed	Ndr kinases regulate retinal interneuron proliferation and homeostasis.	STK38 STK38L	9.26e-06	5	34	2	30135513
Pubmed	Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases.	STK38 STK38L	9.26e-06	5	34	2	15067004
Pubmed	Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.	STK38 STK38L	1.39e-05	6	34	2	36446521
Pubmed	Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers.	MTMR3 STK38 TUT4 PLA2G4F KLHL8 STK38L	6.82e-05	730	34	6	34857952
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY10 ADCY6	8.38e-05	14	34	2	14993377
Pubmed	Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.	STK38 STK38L	1.41e-04	18	34	2	20064376
Pubmed	Large-scale phage-based screening reveals extensive pan-viral mimicry of host short linear motifs.	TEX14 RNF11	2.53e-04	24	34	2	37100772
Pubmed	Embryonic Steroids Control Developmental Programming of Energy Balance.	CACNA1B PCK1	3.21e-04	27	34	2	34599818
Pubmed	SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation.	STK38 STK38L	9.35e-04	46	34	2	29969578
Cytoband	Ensembl 112 genes in cytogenetic band chr1p32	DMRTA2 TUT4 RNF11	2.09e-04	155	34	3	chr1p32
Cytoband	Ensembl 112 genes in cytogenetic band chr11q11	OR4S2 OR4C16	4.08e-04	40	34	2	chr11q11
Cytoband	11q11	OR4S2 OR4C16	5.64e-04	47	34	2	11q11
Cytoband	1p32.3	DMRTA2 TUT4	9.48e-04	61	34	2	1p32.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	CACNA1B FPGS ENTR1	1.79e-03	325	34	3	chr9q34
Cytoband	Ensembl 112 genes in cytogenetic band chr1p22	KYAT3 ABCA4	4.66e-03	137	34	2	chr1p22
Cytoband	Ensembl 112 genes in cytogenetic band chr15q15	PLA2G4F FRMD5	5.34e-03	147	34	2	chr15q15
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY10 ADCY6	5.20e-05	10	20	2	53
GeneFamily	Olfactory receptors, family 4	OR4S2 OR4C16	8.82e-03	129	20	2	151
Disease	testosterone measurement	DMRTA2 MGAT5 KLHL8 ADCY6 FRMD5 SKOR2	2.61e-03	1275	33	6	EFO_0004908
Disease	alkaline phosphatase measurement	PHKB MGAT5 STK38L PCK1 FRMD5	5.08e-03	1015	33	5	EFO_0004533
Disease	sleep duration, triglyceride measurement	KLHL8 FRMD5	6.05e-03	104	33	2	EFO_0004530, EFO_0005271
Disease	free androgen index	KLHL8 ADCY6 SKOR2	8.32e-03	374	33	3	EFO_0007005
Disease	glucose measurement	MTMR3 ENTR1 DENND2C	8.68e-03	380	33	3	EFO_0004468

Protein segments in the cluster

Peptide	Gene	Start	Entry
QMPYPCFVDDSFMII	ABCA4	636	P78363
TMPTCSFPEYFIGNM	ADCY6	806	O43306
PERPFMDYFDGVLMF	ADCY10	31	Q96PN6
TFVVSPPFEYFIMAM	CACNA1B	1466	Q00975
GFRPPMDYAFSDLMR	DMRTA2	496	Q96SC8
MHDPFAMRPFFGYNF	PCK1	476	P35558
PYMPYEFTCEGMLQR	MGAT5	601	Q09328
ITSFPFSPGMYFEMI	LGALS8	256	O00214
ACVIPYFRAMFLSEM	KLHL8	86	Q9P2G9
IPFFFMYMVAISGNC	OR51M1	41	Q9H341
VIFFGPCTFMYMRPD	OR4S2	246	Q8NH73
PCTFMYMRPDTTFSE	OR4S2	251	Q8NH73
FVINRPDTPYGMMNF	PLA2G4F	791	Q68DD2
VFYAMSPVAPRDFML	RGL3	681	Q3MIN7
GFMLTPIAMSFPFCR	OR2T10	156	Q8NGZ9
PPFTMCFRVKFYPAD	FRMD5	86	Q7Z6J6
FFGIRPAFMCYVPSP	ENTR1	51	Q96C92
VEPMSCYMEHRFLFP	DNAAF9	861	Q5TEA3
VYPFMRSVMEAPFPA	DENND2C	621	Q68D51
CVSMPPYFRFLTLMA	FPGS	171	Q05932
YMCPFMQFIEGGRRF	SEC24C	431	P53992
VPFYDCYEPMVRMAG	KYAT3	156	Q6YP21
CYEPMVRMAGATPVF	KYAT3	161	Q6YP21
PIFFLYMMIDGVFRG	PHKB	366	Q93100
PEYYPNCEVVFMGMA	MTMR3	336	Q13615
PCIFMYTCLATVFPM	OR4C16	251	Q8NGL9
ICMMDFVYGDPIRFL	RNF11	101	Q9Y3C5
MFLEIMAPVYPICFT	RUSF1	176	Q96GQ5
IMYEMLIGYPPFCSE	STK38	311	Q15208
VIMYEMLIGYPPFCS	STK38L	311	Q9Y2H1
DEPTFSFFSGPYMVM	TEX14	246	Q8IWB6
PAGRKDAFYPPFCMF	SKOR2	456	Q2VWA4
EKIFMPFRMSGYIPF	SFXN5	101	Q8TD22
GIPSYCFALMVMFFL	TUT4	516	Q5TAX3
MRFTCEMFHPNIYPD	UBE2G2	71	P60604
LCPLPFSMEEMFGFI	UNC79	656	Q9P2D8