Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiondiacylglycerol binding

UNC13B UNC13A

1.02e-0416192GO:0019992
GeneOntologyMolecularFunctionsyntaxin-1 binding

UNC13B UNC13A

2.34e-0424192GO:0017075
GeneOntologyMolecularFunctionsyntaxin binding

UNC13B UNC13A

3.06e-0387192GO:0019905
GeneOntologyBiologicalProcessdense core granule docking

UNC13B UNC13A

8.04e-072192GO:0061790
GeneOntologyBiologicalProcessdense core granule priming

UNC13B UNC13A

4.82e-064192GO:0061789
GeneOntologyBiologicalProcesspresynaptic dense core vesicle exocytosis

UNC13B UNC13A

3.60e-0510192GO:0099525
GeneOntologyBiologicalProcessneuronal dense core vesicle exocytosis

UNC13B UNC13A

5.28e-0512192GO:0099011
GeneOntologyBiologicalProcessregulation of synaptic vesicle priming

UNC13B UNC13A

7.27e-0514192GO:0010807
GeneOntologyBiologicalProcessdense core granule exocytosis

UNC13B UNC13A

8.38e-0515192GO:1990504
GeneOntologyBiologicalProcesssynaptic vesicle docking

UNC13B UNC13A

1.08e-0417192GO:0016081
GeneOntologyBiologicalProcessregulation of short-term neuronal synaptic plasticity

UNC13B UNC13A

1.84e-0422192GO:0048172
GeneOntologyBiologicalProcesscalcium ion-regulated exocytosis of neurotransmitter

UNC13B UNC13A

2.38e-0425192GO:0048791
GeneOntologyBiologicalProcessdense core granule localization

UNC13B UNC13A

3.00e-0428192GO:0032253
GeneOntologyBiologicalProcesssynaptic vesicle priming

UNC13B UNC13A

3.68e-0431192GO:0016082
GeneOntologyBiologicalProcessinnervation

UNC13B UNC13A

4.43e-0434192GO:0060384
GeneOntologyBiologicalProcesssecretory granule localization

UNC13B UNC13A

4.43e-0434192GO:0032252
GeneOntologyBiologicalProcessvesicle docking involved in exocytosis

UNC13B UNC13A

7.43e-0444192GO:0006904
GeneOntologyCellularComponentpresynaptic active zone cytoplasmic component

UNC13B UNC13A

1.96e-0423192GO:0098831
GeneOntologyCellularComponentMLL1 complex

CHD8 PHF20

3.82e-0432192GO:0071339
GeneOntologyCellularComponentMLL1/2 complex

CHD8 PHF20

4.06e-0433192GO:0044665
GeneOntologyCellularComponentcalyx of Held

UNC13B UNC13A

4.84e-0436192GO:0044305
GeneOntologyCellularComponentcell cortex region

UNC13B UNC13A

7.57e-0445192GO:0099738
GeneOntologyCellularComponenthistone methyltransferase complex

CHD8 PHF20

2.09e-0375192GO:0035097
DomainUnc-13

UNC13B UNC13A

2.94e-063192IPR027080
DomainMunc13_dom-2

UNC13B UNC13A

9.79e-065192IPR014772
DomainMembr_traf_MHD

UNC13B UNC13A

9.79e-065192PF10540
DomainDUF1041

UNC13B UNC13A

9.79e-065192SM01145
DomainMHD2

UNC13B UNC13A

9.79e-065192PS51259
DomainMunc13_subgr_dom-2

UNC13B UNC13A

9.79e-065192IPR019558
DomainDUF1041

UNC13B UNC13A

2.05e-057192PF06292
DomainMunc13_1

UNC13B UNC13A

2.05e-057192IPR014770
DomainCAPS_dom

UNC13B UNC13A

2.05e-057192IPR010439
DomainMHD1

UNC13B UNC13A

2.05e-057192PS51258
DomainZINC_FINGER_C2H2_2

ZNF660 ZNF598 INSM2 ZFHX3 PHF20

8.69e-04775195PS50157
DomainZINC_FINGER_C2H2_1

ZNF660 ZNF598 INSM2 ZFHX3 PHF20

8.79e-04777195PS00028
DomainZnf_C2H2-like

ZNF660 ZNF598 INSM2 ZFHX3 PHF20

9.80e-04796195IPR015880
DomainZnf_C2H2

ZNF660 ZNF598 INSM2 ZFHX3 PHF20

1.03e-03805195IPR007087
DomainZnF_C2H2

ZNF660 ZNF598 INSM2 ZFHX3 PHF20

1.05e-03808195SM00355
DomainC1_1

UNC13B UNC13A

1.51e-0357192PF00130
DomainZF_DAG_PE_1

UNC13B UNC13A

1.90e-0364192PS00479
DomainZF_DAG_PE_2

UNC13B UNC13A

1.90e-0364192PS50081
DomainC1

UNC13B UNC13A

1.96e-0365192SM00109
DomainPE/DAG-bd

UNC13B UNC13A

2.02e-0366192IPR002219
Domainzf-C2H2

ZNF660 INSM2 ZFHX3 PHF20

4.67e-03693194PF00096
DomainPeptidase_S1A

HGF PROZ

5.80e-03113192IPR001314
DomainTRYPSIN_DOM

HGF PROZ

6.00e-03115192PS50240
DomainTryp_SPc

HGF PROZ

6.21e-03117192SM00020
DomainTrypsin

HGF PROZ

6.62e-03121192PF00089
DomainTrypsin_dom

HGF PROZ

6.62e-03121192IPR001254
DomainPeptidase_S1_PA

HGF PROZ

6.84e-03123192IPR009003
DomainC2

UNC13B UNC13A

7.72e-03131192PF00168
DomainC2

UNC13B UNC13A

8.42e-03137192SM00239
DomainC2

UNC13B UNC13A

9.02e-03142192PS50004
Domain-

UNC13B UNC13A

9.76e-031481922.60.40.150
Domain-

ZNF598 USP13 PHF20

1.00e-024491933.30.40.10
DomainZnf_RING/FYVE/PHD

ZNF598 USP13 PHF20

1.07e-02459193IPR013083
DomainC2_dom

UNC13B UNC13A

1.19e-02164192IPR000008
Pubmed

Calcium-Independent Exo-endocytosis Coupling at Small Central Synapses.

UNC13B UNC13A

2.83e-07219231851910
Pubmed

Formation and Maintenance of Functional Spines in the Absence of Presynaptic Glutamate Release.

UNC13B UNC13A

2.83e-07219228426965
Pubmed

Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming.

UNC13B UNC13A

2.83e-07219228489077
Pubmed

A fluorescent nanosensor paint detects dopamine release at axonal varicosities with high spatiotemporal resolution.

UNC13B UNC13A

2.83e-07219235613050
Pubmed

Differential control of vesicle priming and short-term plasticity by Munc13 isoforms.

UNC13B UNC13A

2.83e-07219211832228
Pubmed

Dynamic control of synaptic vesicle replenishment and short-term plasticity by Ca(2+)-calmodulin-Munc13-1 signaling.

UNC13B UNC13A

2.83e-07219223770256
Pubmed

Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles.

UNC13B UNC13A

2.83e-07219210440375
Pubmed

Inhibition of exocytosis or endocytosis blocks activity-dependent redistribution of synapsin.

UNC13B UNC13A

2.83e-07219222066784
Pubmed

Membrane bridging by Munc13-1 is crucial for neurotransmitter release.

UNC13B UNC13A

2.83e-07219230816091
Pubmed

Munc13 controls the location and efficiency of dense-core vesicle release in neurons.

UNC13B UNC13A

2.83e-07219223229896
Pubmed

Ultrastructural Correlates of Presynaptic Functional Heterogeneity in Hippocampal Synapses.

UNC13B UNC13A

2.83e-07219232187536
Pubmed

Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming.

UNC13B UNC13A

2.83e-07219212070347
Pubmed

Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs.

UNC13B UNC13A

2.83e-07219211792326
Pubmed

Molecular Mechanisms of Synaptic Vesicle Priming by Munc13 and Munc18.

UNC13B UNC13A

2.83e-07219228772123
Pubmed

A common molecular basis for membrane docking and functional priming of synaptic vesicles.

UNC13B UNC13A

2.83e-07219219558619
Pubmed

Regulation of insulin exocytosis by Munc13-1.

UNC13B UNC13A

2.83e-07219212871971
Pubmed

Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C.

UNC13B UNC13A

2.83e-07219218701688
Pubmed

Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion.

UNC13B UNC13A

2.83e-07219217267576
Pubmed

Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity.

UNC13B UNC13A

2.83e-07219217561838
Pubmed

Role of mammalian homologue of Caenorhabditis elegans unc-13-1 (Munc13-1) in the recruitment of newcomer insulin granules in both first and second phases of glucose-stimulated insulin secretion in mouse islets.

UNC13B UNC13A

2.83e-07219222814762
Pubmed

Munc13 genotype regulates secretory amyloid precursor protein processing via postsynaptic glutamate receptors.

UNC13B UNC13A

2.83e-07219223070049
Pubmed

Heterogeneous Presynaptic Distribution of Munc13 Isoforms at Retinal Synapses and Identification of an Unconventional Bipolar Cell Type with Dual Expression of Munc13 Isoforms: A Study Using Munc13-EXFP Knock-in Mice.

UNC13B UNC13A

8.48e-07319233105896
Pubmed

Munc13- and SNAP25-dependent molecular bridges play a key role in synaptic vesicle priming.

UNC13B UNC13A

8.48e-07319237343100
Pubmed

Interaction between Munc13-1 and RIM is critical for glucagon-like peptide-1 mediated rescue of exocytotic defects in Munc13-1 deficient pancreatic beta-cells.

UNC13B UNC13A

8.48e-07319217639022
Pubmed

Nonconserved Ca(2+)/calmodulin binding sites in Munc13s differentially control synaptic short-term plasticity.

UNC13B UNC13A

8.48e-07319222966208
Pubmed

The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse.

UNC13B UNC13A

8.48e-07319223658173
Pubmed

Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse.

UNC13B UNC13A

8.48e-07319215988013
Pubmed

Transient, phorbol ester-induced DOC2-Munc13 interactions in vivo.

UNC13B UNC13A

1.70e-06419210488064
Pubmed

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity.

UNC13B UNC13A

1.70e-06419219996097
Pubmed

Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing.

UNC13B UNC13A

1.70e-06419215123597
Pubmed

ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones.

UNC13B UNC13A

1.70e-06419228264913
Pubmed

RIM, Munc13, and Rab3A interplay in acrosomal exocytosis.

UNC13B UNC13A

2.82e-06519222248876
Pubmed

An active vesicle priming machinery suppresses axon regeneration upon adult CNS injury.

UNC13B UNC13A

2.82e-06519234706221
Pubmed

A Trio of Active Zone Proteins Comprised of RIM-BPs, RIMs, and Munc13s Governs Neurotransmitter Release.

UNC13B UNC13A

2.82e-06519232755572
Pubmed

Disentangling the Roles of RIM and Munc13 in Synaptic Vesicle Localization and Neurotransmission.

UNC13B UNC13A

2.82e-06519233139401
Pubmed

Identification of a Munc13-sensitive step in chromaffin cell large dense-core vesicle exocytosis.

UNC13B UNC13A

2.82e-06519226575293
Pubmed

Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles.

UNC13B UNC13A

4.24e-06619228635948
Pubmed

SNAREs and traffic.

UNC13B UNC13A

5.93e-06719215893389
Pubmed

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones.

UNC13B UNC13A

5.93e-06719236398873
Pubmed

Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.

UNC13B UNC13A

7.90e-06819225609709
Pubmed

SNARE protein recycling by αSNAP and βSNAP supports synaptic vesicle priming.

UNC13B UNC13A

1.27e-051019221040848
Pubmed

Molecular and functional architecture of striatal dopamine release sites.

UNC13B UNC13A

1.55e-051119234767769
Pubmed

The morphological and molecular nature of synaptic vesicle priming at presynaptic active zones.

UNC13B UNC13A

1.55e-051119225374362
Pubmed

Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.

UNC13B UNC13A

9.12e-052619217124501
Pubmed

The synaptic vesicle cycle.

UNC13B UNC13A

1.30e-043119215217342
Pubmed

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.

CHD8 PHF20

1.30e-043119215960975
CytobandEnsembl 112 genes in cytogenetic band chr7q21

GNGT1 HGF

2.45e-03178192chr7q21
GeneFamilyUNC13 homologs

UNC13B UNC13A

3.34e-064142836
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF660 ZNF598 INSM2 ZFHX3

1.79e-0371814428
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A4 OTOG ASTE1

1.34e-05110193c80d1c3df75648e2c8f6832279c2acca63d76681
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13B ZFHX3 ABO

4.74e-051681937abaddbcc55e44653d54aa15464266aa6bd5c9d2
ToppCellControl-Epithelial_cells-ECM-high_epithelial|Control / group, cell type (main and fine annotations)

UNC13B COL4A4 PTPRE

4.91e-05170193e2023d66e70983c87dacbd6181d3426488d1fc57
ToppCelldroplet-Lung-LUNG-30m-Myeloid-Basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGF SPDYA PTPRE

5.17e-051731934f849d236ee358ad30ac977745ac43c8e9778e94
ToppCelldroplet-Lung-LUNG-30m-Myeloid-basophil|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGF SPDYA PTPRE

5.17e-0517319339c3b8313354c4c60764597507a2505dcfa4e8c7
ToppCellControl-Epithelial_cells-AT1|Control / group, cell type (main and fine annotations)

UNC13B COL4A4 PTPRE

5.26e-05174193548d7f2b958a2bfd2c95eb049ceaab55a559c77d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

UNC13B ZFHX3 ABO

5.54e-051771934c069f0d044a96118090b85ca592a21d6b5d9399
ToppCell5'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HGF USP13 PTPRE

5.73e-0517919340c65e8623547aeb80f9cd2366e29072467ce069
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

HGF USP13 ZFHX3

5.92e-051811932b9b460239d67fd480cee60820cdb306109d3567
ToppCellPBMC-Convalescent-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

HGF USP13 ZFHX3

5.92e-051811932a1aa4a0ec7bc367857beaff543135e4345c835b
ToppCell5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

HGF USP13 PTPRE

6.42e-051861939579180db2a0bf3f043b4d169f9a08cdc45b459a
ToppCellT_cells-CD56_bright_CD16-_NK_cells|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis

ZNF660 COL4A4 ZFHX3

7.16e-05193193826457e2aafdb61ead8a0a44d8cf9088d310684b
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

UNC13B COL4A4 PTPRE

7.84e-051991938587bd98de7767a575088afbea07a1feb4516b9b
ToppCellCOVID-19-COVID-19_Mild-Others-HSPC|COVID-19_Mild / Disease, condition lineage and cell class

ZNF660 TCN1 ABO

7.84e-051991930230103c37ae3aff58240739b89f2c36b1e39a69
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Rgs14_(CA2_Principal_cells)|Hippocampus / BrainAtlas - Mouse McCarroll V32

HGF PHF20

3.68e-0467192771fc7c4917b5dc5ebf1b7be304d62902f0b75cc
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Excitatory_Neuron.Slc17a7.Rgs14_(CA2_Principal_cells)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

HGF PHF20

3.68e-0467192f56d8787ab2170997d28a2f66d83b4c18362b97d
ToppCellHippocampus-Macroglia-POLYDENDROCYTE-P5-P5_2-Sox4-POLYDENDROCYTE_(Neurogenesis.Sox4.Gabra5)|Hippocampus / BrainAtlas - Mouse McCarroll V32

INSM2 PROZ

4.24e-0472192480653f8bd0ef118cb8d541103692e3ec8a1b58d
ToppCellPosterior_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Sema3e|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

GNGT1 HGF

4.36e-047319251bcbb57ee6c45cad88cb3e2cedab2cf3503b2a5
ToppCelldroplet-Fat-Scat-21m-Hematologic-erythroblast|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGF SPDYA

7.68e-04971926fff45d4c4bbd81a67e1ad12b131cfe6a5ab37e6
ToppCelldroplet-Fat-Scat-21m-Hematologic|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGF SPDYA

7.68e-0497192440d45ecfc9b66cb61d734118601e745892d51e3
ToppCelldroplet-Liver-Hepatocytes-18m-Myeloid-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GNGT1 UNC13A

7.84e-049819295162072f3afc95e46f29db3d79ebd930bc09726
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF660 SPDYA

9.33e-041071925bae4b3aede9bcbf7e88414e3453973cc8b0c3e7
ToppCell368C-Epithelial_cells-Epithelial-B_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ZNF660 SPDYA

9.33e-04107192410b37beffaf637a2a64c9d0ce7baf81f4bc667c
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar-Mes-Like-Differentiating_AT1|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

COL4A4 OTOG

9.51e-04108192d620f07243c2628494e689bbfabc14c453f4b1f4
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-hematologic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HGF OTOG

1.29e-03126192f2ec5aa6c649ae1ff99519f6897cf207dc292edf
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-hematologic-erythrocytic|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HGF OTOG

1.29e-03126192cd02f3d4a3fadd24f3a298639b392f0354d227d2
ToppCellSmart-seq2-lymph_node_(Smart-seq2)-hematologic-erythrocytic-erythrocyte|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

HGF OTOG

1.29e-0312619261a7e400cbc81691b21cd3c37376c1d19fec2270
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-5|TCGA-Brain / Sample_Type by Project: Shred V9

INSM2 OTOG

1.52e-03137192a7c76201b8901b2ef7ebbb4dfe0cec0dc4534ef5
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Mucinous|TCGA-Stomach / Sample_Type by Project: Shred V9

TCN1 HGF

1.52e-03137192291b4eeaf21ec951695621161dbc2de3e82ca993
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN1 PROZ

1.57e-0313919282bf5ba69a907fbd9b4e2b2dd1dd27b8c4c75f25
ToppCellfacs-Liver-Hepatocytes-3m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN1 PROZ

1.57e-03139192fc4b39ac9a10cf0acacfebbc4295edf324d930d5
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN1 PROZ

1.57e-03139192fc9ac09c2106e88104a52575832d71d17765eec8
ToppCellfacs-Liver-Hepatocytes-3m-Epithelial-hepatocyte|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN1 PROZ

1.57e-031391924ddfbc36a0560fb70594627178bff652ab1ea3e9
ToppCellAT1-AT2_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

COL4A4 USP13

1.59e-0314019245d52a086ced8d58e01ac51ac4a90338e8649b16
ToppCellRV-14._Fibroblast_III|RV / Chamber and Cluster_Paper

COL4A4 ZFHX3

1.59e-03140192b4fee8eb6bf855b364b00bda3f78e49d851bbca0
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Neuronal-cortical_neurons_1|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

HGF INSM2

1.61e-0314119273b3e967357cba7585d97ec9e9d48d3e94ebe31e
ToppCell343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_4|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

UNC13A ABO

1.66e-03143192ce045ec7c311a1797ae562bec114f9e90604d063
ToppCell10x5'v1-week_12-13-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HGF ABO

1.68e-031441924f46a22dba047d35076e7768e834b0cbcecc8417
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HGF UNC13A

1.70e-0314519207acbf086cffce0628accf078d31bf190f803988
ToppCellEpithelial-B_(AT1-AT2-progenitors)|World / shred on cell class and cell subclass (v4)

TCN1 COL4A4

1.72e-031461924511916904c1fac252cb68e871b782207f8137b3
ToppCell10x3'2.3-week_12-13-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

HGF ABO

1.80e-03149192797b5f267e86fbe1d7af99df514d8074446603c6
ToppCellPND01-03-samps-Epithelial-Alveolar_epithelial-AT1_-_meso|PND01-03-samps / Age Group, Lineage, Cell class and subclass

UNC13B COL4A4

1.82e-031501926a13e4c4b9c9e54a5016573a37132465ec1c8f99
ToppCelldroplet-Lung-30m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l14|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

HGF PTPRE

1.87e-031521920fda8980b10ce16179dea92301db74d728f41794
ToppCellPND07-Immune-Immune_Myeloid-Granulocytic|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HGF PTPRE

1.92e-03154192f92d83c5f8b532fe5624f1cd352632f543d96ea9
ToppCellfacs-Liver-Hepatocytes|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TCN1 PROZ

1.97e-03156192e2cda3ad4e5f44a80133864c5a38b766afb952ce
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Endothelial-endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSM2 OTOG

1.97e-031561921c2920f4356789a9c11d5ea1eaafb18a50b19ed7
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Endothelial-Endothelial_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSM2 OTOG

1.97e-03156192a45fbe02cd03bd4a097f21368bc1179779ba0db8
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Endothelial|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

INSM2 OTOG

1.97e-031561920695ac0f02d059ecf813d61d3c9d4c76d1d85834
ToppCelldroplet-Kidney-nan-18m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGF PTPRE

1.99e-03157192eb64a4e89843895d16015c7d51805f164ed7ea5b
ToppCellMonocytes-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

SPDYA PTPRE

2.01e-03158192c3096b3a914a1a15ebe3664613e94b951f8555fc
ToppCellBAL-Severe-cDC_4|Severe / Compartment, Disease Groups and Clusters

UNC13B ZFHX3

2.01e-0315819273f66689ef59f71b14cb7141ca5951cc47fe57c1
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-epithelial_cell_of_thymus|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF598 COL4A4

2.01e-03158192e7db50d6dfaf7280a73a0d5b5aa4f43ea2762d72
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF598 COL4A4

2.01e-0315819212661763d1c309106801cb710c04cd2b62d16cba
ToppCellfacs-Lung-EPCAM-3m-Myeloid-Nonclassical_Monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGF PTPRE

2.01e-03158192b0508a600994090c6aafd8d779437190a33ad821
ToppCellfacs-Thymus-Thymus_Flowthrough-18m-Epithelial-TECs|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZNF598 COL4A4

2.01e-031581920792c39e6fc0745095af7812de2d50949540d60f
ToppCellfacs-Lung-EPCAM-3m-Myeloid-non-classical_monocyte|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HGF PTPRE

2.01e-03158192a816cc095452308d06f87b77467e2a8c6361fd2a
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

UNC13B ABO

2.04e-03159192e6ff9d2bce62bf9ea173af80b688eeb40fa4ea4c
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 HGF

2.04e-031591922607b562903228274fbd96168ba826782fab0b53
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 HGF

2.04e-03159192e812cbde59188924c6277c3feadf1a9592fa62a4
ToppCellPND01-03-samps|World / Age Group, Lineage, Cell class and subclass

TCN1 COL4A4

2.09e-031611921973b112d8d67aacc02751797d0148e7b53bfa66
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma|TCGA-Brain / Sample_Type by Project: Shred V9

INSM2 UNC13A

2.09e-031611925f6b2d7f80a8ee16651e304481d2da3fae313824
ToppCell10x5'-bone_marrow-Mast-Mast_cells|bone_marrow / Manually curated celltypes from each tissue

TCN1 HGF

2.09e-0316119215ba7e69699558353cfeecdcf1dbc2e147379ed6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 HGF

2.12e-03162192b936f8040dcd4db621ccded19237af8df7d0ed6e
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen-high_Fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 HGF

2.12e-031621925f009b231f21861afee9cc0c569082e1135f929c
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCN1 PROZ

2.14e-03163192f6847f47a8856c0d4136c1af317432d45eccfde9
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCN1 PROZ

2.14e-03163192a1fbefe53523a9879a4d4b493071059798b5f917
ToppCell5'-Airway_Nasal_SMG-Epithelial|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCN1 PROZ

2.14e-03163192454a5e87e2f9f66e38cc5aa1b433c47b54c9be42
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell-SMG_duct-SMG_duct_L.0.6.2.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCN1 PROZ

2.14e-03163192be6cc44df9a2b10dce1a353717c279c3558f8fec
ToppCell5'-Airway_Nasal_SMG|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCN1 PROZ

2.14e-03163192d8450bf9c6d2ec5dd1472952c9e65f82f995337a
ToppCell5'-Airway_Nasal_SMG-Epithelial-Epithelial_transtional-secretory-SMG_acinar_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

TCN1 PROZ

2.14e-03163192d9bd9d90cfa4e85d5ea51f8f3ee14a700571f508
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell-mucous|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 INSM2

2.17e-03164192f1423f4434af4af9c60c8a5b0b0abec4a7df9401
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial-lung_secretory_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 INSM2

2.17e-03164192cdb8cd2d6b369189ea77e4946738e2816d502e03
ToppCellfacs-Trachea-18m-Epithelial-glandular_epithelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

COL4A4 INSM2

2.17e-031641925dbfcdd450f652b16d97da53b528d4584b0eabcf
ToppCellInt-URO-Myeloid-cDC1|Int-URO / Disease, Lineage and Cell Type

TCN1 PTPRE

2.17e-03164192f4628a7ff0dc765a5337ab499b3d61fc25573a16
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

HGF UNC13A

2.19e-03165192cca3ba9d7d30404e3e683b8cfd500c348a4974b9
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 UNC13A

2.19e-031651929de841c1c95967c562720feba930246debc626fd
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZFHX3 ABO

2.19e-03165192fee7f2f8d0e25c0d067adc73f8913721bd709a3e
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal--glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 UNC13A

2.19e-03165192cdc94a640ec01c6892521bcd6f0ee0a66ff23866
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ZFHX3 UNC13A

2.19e-03165192a612a7d3a5415ecacc3df8fbff0ce498f982aad0
ToppCellwk_08-11-Mesenchymal-Fibroblast-Alveolar_fibro|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

HGF ABO

2.22e-0316619265dafed953b01a9830b54309af75c7a561e88336
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B ABO

2.22e-03166192c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Diffuse-3|TCGA-Stomach / Sample_Type by Project: Shred V9

COL4A4 HGF

2.25e-03167192d2230c894ccf9dbba9196e079ae81f384d43da63
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid-nan|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPDYA ZFHX3

2.25e-03167192a21a2b301d0a3d7a41e605f7a3c37548962a331d
ToppCellfacs-Brain_Myeloid-Hippocampus-24m|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPDYA ZFHX3

2.25e-031671920e746483773bde6582874a33591ab2a578d724eb
ToppCellP15-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

COL4A4 USP13

2.25e-031671925c3d0763f73628c71c71f9883556bb4f1639f3cc
ToppCellfacs-Brain_Myeloid-Hippocampus-24m-Myeloid|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPDYA ZFHX3

2.25e-031671927f3224af9b30082b927a822b91f96e0c88151b4e
ToppCell390C-Lymphocytic-NK_cells-NK_cell_E|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

USP13 PROZ

2.25e-031671926c2dade24a88af04b2c90a7e4f8dd7ccea9e94d1
ToppCelldroplet-Heart-nan-24m-Hematologic-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC13B PROZ

2.25e-03167192bad33497ceeab968a7eb8a48b921c6f936390743
ToppCell367C-Lymphocytic-NK_cells-NK_cell_D3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ZFHX3 PTPRE

2.25e-0316719299db8871c62336bd215efb65e969783d2b6003b0
ToppCellControl|World / group, cell type (main and fine annotations)

UNC13B GNGT1

2.27e-03168192a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL4A4 HGF

2.27e-03168192d19a115365c5415e51c039718d7669de788fcf33
ToppCell390C-Lymphocytic-NK_cells-NK_cell_E|NK_cells / Donor, Lineage, Cell class and subclass (all cells)

USP13 PROZ

2.27e-03168192d8f485f8459532a2cb0bef899e6569142cf75685
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)--|Striatum / BrainAtlas - Mouse McCarroll V32

ZNF598 CHD8

2.30e-031691925375eb52ebadccb7bfff997a11985f23e81014d6
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)|Striatum / BrainAtlas - Mouse McCarroll V32

ZNF598 CHD8

2.30e-03169192c3bf0cb67f200d02d5a021754e9b2a68d23ea168
ToppCellfacs-Heart-LV-18m-Mesenchymal|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL4A4 HGF

2.30e-03169192849a8f8509c58d65462a09c84d58b6ecdc8934f5
ToppCellRA-01._Fibroblast_I|RA / Chamber and Cluster_Paper

COL4A4 ZFHX3

2.30e-031691926373562ab3b1765060212a6a53d6543e7e942e80
ToppCellStriatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Sgol2a_(Very_small_cluster)-|Striatum / BrainAtlas - Mouse McCarroll V32

ZNF598 CHD8

2.30e-031691921c132d21255f5a5174ac38db4e91927f9093418e
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-5|TCGA-Bladder / Sample_Type by Project: Shred V9

UNC13A OTOG

2.30e-031691929c4e83fe8225d16173a103bf5a57b17d623be923
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L6_FEZF2_CPZ|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ZFHX3 ABO

2.33e-03170192021c3e45955d18e241f7d98acdf22076fee4fc43
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

UNC13B PTPRE

2.33e-03170192a2c738e441ced90eeeb1fcc6ca3269b918aaa298
Diseasegraft-versus-host disease (is_implicated_in)

HGF ABO

5.31e-0517192DOID:0081267 (is_implicated_in)
Diseasecardioembolic stroke

ZFHX3 ABO PHF20

1.70e-04170193EFO_1001976
DiseaseAcute Cerebrovascular Accidents

ZFHX3 ABO

5.51e-0454192C0751956
DiseaseAntithrombotic agent use measurement

ZFHX3 ABO

5.72e-0455192EFO_0009925
Diseasecalcium measurement

HGF ZFHX3 CHD8 ABO

6.11e-04628194EFO_0004838
DiseaseCerebrovascular accident

ZFHX3 ABO

7.26e-0462192C0038454
DiseaseNonsyndromic Deafness

HGF OTOG

1.23e-0381192C3711374
Diseasecomplement factor D measurement

GNGT1 ABO

1.62e-0393192EFO_0020283

Protein segments in the cluster

PeptideGeneStartEntry
ELQVCVKDYCFARED

UNC13A

1616

Q9UPW8
REIRYLDEVLEANCC

AKAP2

51

Q9Y2D5
ERDVETICRAILVYC

CHD8

1476

Q9HCK8
CERRFLSEVDYLVCV

ABO

196

P16442
EEAIRPYVSRCAVCE

COL4A4

1556

P53420
RVCFVQCFSEADRDI

ASTE1

131

Q2TB18
VCVEDCVVLVDYTIR

PTPRE

261

P23469
CCEEVRDYVEERSGE

GNGT1

36

P63211
VRYEVCDIPQCSEVE

HGF

196

P14210
IVRVEYRCPECDKVF

INSM2

286

Q96T92
LDEVTQRCVYLEDCV

OTOG

1451

Q6ZRI0
DRYDFEVVRCICEVQ

PHF20

646

Q9BVI0
IDYRAIVSRRCCEEV

SPDYA

171

Q5MJ70
KECYEEICVYEEARE

PROZ

56

P22891
QLCEICEVSEENYIR

TCN1

21

P20061
ERVQAEKRQYVCTEC

ZNF660

41

Q6AZW8
QICVKDYCFAREDRV

UNC13B

1511

O14795
EQRYCAVCREELRQV

ZNF598

61

Q86UK7
DVFRFLVEERIQCCQ

USP13

471

Q92995
CEVCDYETNVARNLR

ZFHX3

806

Q15911