Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	structural constituent of nuclear pore	NUP155 NUP188 NUP160	7.88e-05	25	67	3	GO:0017056
GeneOntologyCellularComponent	nuclear pore inner ring	NUP155 NUP188	2.68e-05	3	63	2	GO:0044611
GeneOntologyCellularComponent	Gtr1-Gtr2 GTPase complex	RRAGA RRAGB	5.34e-05	4	63	2	GO:1990131
MousePheno	decreased trabecular bone connectivity density	P3H4 NOTCH3 VCP	2.78e-05	16	53	3	MP:0010933
Domain	BTK	BMX RASA4 RASA4B	3.33e-06	9	65	3	SM00107
Domain	Znf_Btk_motif	BMX RASA4 RASA4B	3.33e-06	9	65	3	IPR001562
Domain	BTK	BMX RASA4 RASA4B	3.33e-06	9	65	3	PF00779
Domain	ZF_BTK	BMX RASA4 RASA4B	3.33e-06	9	65	3	PS51113
Domain	Ank_2	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	9.60e-06	215	65	7	PF12796
Domain	Ank	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	1.41e-05	228	65	7	PF00023
Domain	-	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	2.42e-05	248	65	7	1.25.40.20
Domain	ANK	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	2.61e-05	251	65	7	SM00248
Domain	ANK_REPEAT	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	2.75e-05	253	65	7	PS50088
Domain	Ankyrin_rpt-contain_dom	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	2.82e-05	254	65	7	IPR020683
Domain	ANK_REP_REGION	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	2.82e-05	254	65	7	PS50297
Domain	Ankyrin_rpt	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 TRPV5 NOTCH3	3.43e-05	262	65	7	IPR002110
Domain	-	RASA4 RASA4B	3.57e-05	3	65	2	4.10.1130.10
Domain	Gtr1_RagA	RRAGA RRAGB	7.12e-05	4	65	2	PF04670
Domain	Gtr1_RagA	RRAGA RRAGB	7.12e-05	4	65	2	IPR006762
Domain	-	LRRC14B TONSL LRRC14 FBXL19 STK11IP LRRC73 NLRP8	1.23e-04	321	65	7	3.80.10.10
Domain	L_dom-like	LRRC14B TONSL LRRC14 FBXL19 STK11IP LRRC73 NLRP8	1.40e-04	328	65	7	IPR032675
Domain	LRR_6	TONSL LRRC14 NLRP8	9.28e-04	55	65	3	PF13516
Domain	RasGAP	RASA4 RASA4B	1.06e-03	14	65	2	SM00323
Domain	RasGAP_CS	RASA4 RASA4B	1.06e-03	14	65	2	IPR023152
Domain	RasGAP	RASA4 RASA4B	1.22e-03	15	65	2	PF00616
Domain	RAS_GTPASE_ACTIV_1	RASA4 RASA4B	1.22e-03	15	65	2	PS00509
Domain	RAS_GTPASE_ACTIV_2	RASA4 RASA4B	1.22e-03	15	65	2	PS50018
Domain	-	RASA4 RASA4B	1.39e-03	16	65	2	1.10.506.10
Domain	RasGAP_dom	RASA4 RASA4B	1.76e-03	18	65	2	IPR001936
Domain	Growth_fac_rcpt_	FBN2 FBXL19 LRP1B NOTCH3	2.13e-03	156	65	4	IPR009030
Domain	Leu-rich_rpt	TONSL LRRC14 FBXL19 STK11IP NLRP8	2.52e-03	271	65	5	IPR001611
Domain	EGF_CA	FBN2 LRP1B NOTCH3	3.35e-03	86	65	3	PF07645
Domain	cEGF	FBN2 LRP1B	3.67e-03	26	65	2	IPR026823
Domain	cEGF	FBN2 LRP1B	3.67e-03	26	65	2	PF12662
Domain	hEGF	FBN2 NOTCH3	4.25e-03	28	65	2	PF12661
Domain	EGF_Ca-bd_CS	FBN2 LRP1B NOTCH3	4.70e-03	97	65	3	IPR018097
Domain	EGF_CA	FBN2 LRP1B NOTCH3	4.97e-03	99	65	3	PS01187
Domain	ASX_HYDROXYL	FBN2 LRP1B NOTCH3	5.12e-03	100	65	3	PS00010
Domain	Spectrin/alpha-actinin	AKAP6 SYNE2	5.53e-03	32	65	2	IPR018159
Domain	SPEC	AKAP6 SYNE2	5.53e-03	32	65	2	SM00150
Domain	EGF-type_Asp/Asn_hydroxyl_site	FBN2 LRP1B NOTCH3	6.01e-03	106	65	3	IPR000152
Pathway	REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION	NUP155 NUP188 NUP160	7.59e-05	24	49	3	MM15658
Pathway	REACTOME_POSTMITOTIC_NUCLEAR_PORE_COMPLEX_NPC_REFORMATION	NUP155 NUP188 NUP160	1.09e-04	27	49	3	M29807
Pathway	KEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA	NUP155 NUP188 NUP160	1.50e-04	30	49	3	M47752
Pathway	REACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN	NUP155 NUP188 NUP160	1.82e-04	32	49	3	M29579
Pathway	REACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS	NUP155 NUP188 NUP160	2.00e-04	33	49	3	M27016
Pathway	REACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN	NUP155 NUP188 NUP160	2.19e-04	34	49	3	M27041
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	NUP155 NUP188 NUP160	2.39e-04	35	49	3	M27320
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	NUP155 NUP188 NUP160	2.60e-04	36	49	3	M27245
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	NUP155 NUP188 NUP160	2.60e-04	36	49	3	M26974
Pathway	REACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS	NUP155 NUP188 NUP160	2.82e-04	37	49	3	M1029
Pathway	REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS	NUP155 NUP188 NUP160	2.82e-04	37	49	3	M27038
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	NUP155 NUP188 NUP160 VCP	2.88e-04	92	49	4	MM14951
Pathway	BIOCARTA_BARD1_PATHWAY	FANCC BARD1	3.27e-04	8	49	2	M22050
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	NUP155 NUP188 NUP160	3.30e-04	39	49	3	M27238
Pathway	REACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY	NUP155 NUP188 NUP160	3.56e-04	40	49	3	MM14945
Pathway	REACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS	NUP155 NUP188 NUP160	3.83e-04	41	49	3	M29574
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS	NUP155 NUP188 NUP160	3.83e-04	41	49	3	MM15200
Pathway	REACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS	NUP155 NUP188 NUP160 VCP	4.11e-04	101	49	4	M27253
Pathway	REACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS	NUP155 NUP188 NUP160	4.12e-04	42	49	3	MM15039
Pathway	REACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA	NUP155 NUP188 NUP160	4.42e-04	43	49	3	MM14609
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	NUP155 NUP188 NUP160	4.42e-04	43	49	3	M26975
Pathway	REACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS	NUP155 NUP188 NUP160	4.73e-04	44	49	3	M109
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	NUP155 NUP188 NUP160	5.39e-04	46	49	3	M27397
Pathway	REACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS	NUP155 NUP188 NUP160	5.75e-04	47	49	3	MM14939
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	NUP155 NUP188 NUP160	5.75e-04	47	49	3	M27395
Pathway	REACTOME_GENE_SILENCING_BY_RNA	NUP155 NUP188 NUP160	6.50e-04	49	49	3	MM14837
Pathway	REACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS	NUP155 NUP188 NUP160	6.90e-04	50	49	3	MM14610
Pathway	REACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS	NUP155 NUP188 NUP160	7.31e-04	51	49	3	MM15151
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	NUP155 NUP188 NUP160	8.18e-04	53	49	3	M27212
Pathway	REACTOME_SNRNP_ASSEMBLY	NUP155 NUP188 NUP160	8.64e-04	54	49	3	M29594
Pathway	REACTOME_NUCLEAR_ENVELOPE_BREAKDOWN	NUP155 NUP188 NUP160	9.12e-04	55	49	3	MM14917
Pathway	REACTOME_SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES	NUP155 IRAK2 NUP188 NUP160	9.45e-04	126	49	4	M45009
Pathway	KEGG_MEDICUS_REFERENCE_FLCN_MTORC1_SIGNALING_PATHWAY	RRAGA RRAGB	1.05e-03	14	49	2	M47922
Pathway	KEGG_MEDICUS_REFERENCE_GATOR1_MTORC1_SIGNALING_PATHWAY	RRAGA RRAGB	1.05e-03	14	49	2	M47918
Pathway	REACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS	NUP155 NUP188 NUP160	1.06e-03	58	49	3	MM15149
Pathway	REACTOME_SNRNP_ASSEMBLY	NUP155 NUP188 NUP160	1.06e-03	58	49	3	MM14736
Pathway	REACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS	NUP155 NUP188 NUP160	1.12e-03	59	49	3	M27606
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	NUP155 NUP188 NUP160	1.48e-03	65	49	3	MM15147
Pathway	REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY	NUP155 NUP188 NUP160	1.69e-03	68	49	3	MM14921
Pathway	REACTOME_CELLULAR_RESPONSES_TO_STIMULI	NUP155 RRAGA RRAGB SIN3A NUP188 NUP160 VCP	1.69e-03	505	49	7	MM15548
Pathway	REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES	FANCC NUP155 NUP188 NUP160	1.84e-03	151	49	4	M550
Pathway	REACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS	NUP155 NUP188 NUP160	1.91e-03	71	49	3	M27394
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	NUP155 NUP188 NUP160	2.07e-03	73	49	3	MM14948
Pathway	REACTOME_ISG15_ANTIVIRAL_MECHANISM	NUP155 NUP188 NUP160	2.15e-03	74	49	3	M48006
Pathway	REACTOME_NUCLEAR_ENVELOPE_NE_REASSEMBLY	NUP155 NUP188 NUP160	2.32e-03	76	49	3	M27215
Pathway	REACTOME_GENE_EXPRESSION_TRANSCRIPTION	NUP155 RRAGA BARD1 INTS4 RRAGB SIN3A NUP188 NUP160 NOTCH3 CPSF7	2.34e-03	1022	49	10	MM15436
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	NUP155 NUP188 NUP160	2.41e-03	77	49	3	M27226
Pathway	REACTOME_SUMOYLATION	NUP155 SIN3A NUP188 NUP160	2.78e-03	169	49	4	MM14919
Pathway	REACTOME_GLUCOSE_METABOLISM	NUP155 NUP188 NUP160	2.88e-03	82	49	3	MM15394
Pathway	REACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE	NUP155 NUP188 NUP160	2.88e-03	82	49	3	M27250
Pathway	REACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS	NUP155 NUP188 NUP160	3.09e-03	84	49	3	MM14929
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	NUP155 NUP188 NUP160	3.09e-03	84	49	3	M725
Pathway	REACTOME_MTORC1_MEDIATED_SIGNALLING	RRAGA RRAGB	3.11e-03	24	49	2	M3492
Pathway	REACTOME_GLUCOSE_METABOLISM	NUP155 NUP188 NUP160	3.19e-03	85	49	3	M1870
Pathway	REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS	NUP155 NUP188 NUP160 VCP	3.28e-03	177	49	4	M27476
Pathway	REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM	NUP155 NUP188 NUP160	3.30e-03	86	49	3	MM15413
Pathway	REACTOME_MTORC1_MEDIATED_SIGNALLING	RRAGA RRAGB	3.37e-03	25	49	2	MM14650
Pathway	REACTOME_SARS_COV_2_INFECTION	NUP155 IRAK2 NUP188 NUP160 VCP	3.69e-03	299	49	5	M41727
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	RRAGA RRAGB	3.93e-03	27	49	2	MM15537
Pathway	REACTOME_SUMOYLATION	NUP155 SIN3A NUP188 NUP160	4.14e-03	189	49	4	M27214
Pathway	PID_BARD1_PATHWAY	FANCC BARD1	4.53e-03	29	49	2	M258
Pathway	REACTOME_METALLOPROTEASE_DUBS	BARD1 MYSM1	4.53e-03	29	49	2	MM15291
Pathway	REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK	RRAGA RRAGB	4.53e-03	29	49	2	M19861
Pathway	REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK	RRAGA RRAGB	4.53e-03	29	49	2	MM14980
Pubmed	Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1.	NUP188 ESPL1 NUP160 MED12	1.28e-06	41	68	4	8724849
Pubmed	CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway.	RASA4 RASA4B	3.77e-06	2	68	2	11448776
Pubmed	A novel function of AAA-ATPase p97/VCP in the regulation of cell motility.	FBXL19 VCP	3.77e-06	2	68	2	32002125
Pubmed	An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis.	RASA4 RASA4B	3.77e-06	2	68	2	16041389
Pubmed	DUSP1 interacts with and dephosphorylates VCP to improve mitochondrial quality control against endotoxemia-induced myocardial dysfunction.	DUSP1 VCP	3.77e-06	2	68	2	37464072
Pubmed	RagA is a functional homologue of S. cerevisiae Gtr1p involved in the Ran/Gsp1-GTPase pathway.	RRAGA RRAGB	3.77e-06	2	68	2	9394008
Pubmed	Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases.	RRAGA RRAGB	3.77e-06	2	68	2	7499430
Pubmed	Metabolism. Differential regulation of mTORC1 by leucine and glutamine.	RRAGA RRAGB	1.13e-05	3	68	2	25567907
Pubmed	CD28 inhibits T cell adhesion by recruiting CAPRI to the plasma membrane.	RASA4 RASA4B	1.13e-05	3	68	2	25637021
Pubmed	Pom121 links two essential subcomplexes of the nuclear pore complex core to the membrane.	NUP155 NUP160	1.13e-05	3	68	2	20974814
Pubmed	RagA, but not RagB, is essential for embryonic development and adult mice.	RRAGA RRAGB	1.13e-05	3	68	2	24768164
Pubmed	Nutrient mTORC1 signaling underpins regulatory T cell control of immune tolerance.	RRAGA RRAGB	1.13e-05	3	68	2	31649036
Pubmed	Rag GTPases are cardioprotective by regulating lysosomal function.	RRAGA RRAGB	1.13e-05	3	68	2	24980141
Pubmed	Loss of mitogen-activated protein kinase phosphatase-1 protects from hepatic steatosis by repression of cell death-inducing DNA fragmentation factor A (DFFA)-like effector C (CIDEC)/fat-specific protein 27.	DUSP1 DOCK7	2.25e-05	4	68	2	21521693
Pubmed	Ca2+-dependent monomer and dimer formation switches CAPRI Protein between Ras GTPase-activating protein (GAP) and RapGAP activities.	RASA4 RASA4B	2.25e-05	4	68	2	21460216
Pubmed	YAP plays a crucial role in the development of cardiomyopathy in lysosomal storage diseases.	RRAGA RRAGB	2.25e-05	4	68	2	33373332
Pubmed	Identification of an alternatively spliced variant of Ca2+-promoted Ras inactivator as a possible regulator of RANKL shedding.	RASA4 RASA4B	2.25e-05	4	68	2	16234249
Pubmed	Defining the human deubiquitinating enzyme interaction landscape.	NUP155 KCTD3 ADGRB1 DOCK7 BARD1 LRRC14 NUP188 USP1 NUP160 VCP	2.47e-05	1005	68	10	19615732
Pubmed	Integrated structural analysis of the human nuclear pore complex scaffold.	NUP155 NUP188 NUP160	2.79e-05	30	68	3	24315095
Pubmed	The Structure Inventory of the Nuclear Pore Complex.	NUP155 NUP188 NUP160	2.79e-05	30	68	3	27016207
Pubmed	An inducible CRISPR/Cas9 screen identifies DTX2 as a transcriptional regulator of human telomerase.	STIM2 NUP155 NUP160 NOTCH3 CPSF7	2.81e-05	180	68	5	35198878
Pubmed	DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.	FANCC TONSL BARD1 SIN3A MED12 VCP CPSF7	2.97e-05	453	68	7	29656893
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	NUP155 RRAGA DUSP1 LRRC14 RRAGB NUP188 USP1 NUP160 MED12 VCP CPSF7	3.05e-05	1257	68	11	37317656
Pubmed	Spatial proteomics reveal that the protein phosphatase PTP1B interacts with and may modify tyrosine phosphorylation of the rhomboid protease RHBDL4.	STIM2 RHBDF2 SYNE2 EIF2AK3 VCP	3.73e-05	191	68	5	31177093
Pubmed	SH3BP4 is a negative regulator of amino acid-Rag GTPase-mTORC1 signaling.	RRAGA RRAGB	3.75e-05	5	68	2	22575674
Pubmed	Notch3 and Mef2c proteins are mutually antagonistic via Mkp1 protein and miR-1/206 microRNAs in differentiating myoblasts.	DUSP1 NOTCH3	3.75e-05	5	68	2	23055528
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	NUP155 SYNE2 PHRF1 DOCK7 NUP188 NUP160 MED12 VCP	4.06e-05	653	68	8	22586326
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	ANKRD36B PHRF1 ANKRD36 ZFYVE1	4.73e-05	101	68	4	10997877
Pubmed	Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics.	FBN2 MED12 P3H4	4.87e-05	36	68	3	15717329
Pubmed	A novel human nucleolar protein, Nop132, binds to the G proteins, RRAG A/C/D.	RRAGA RRAGB	5.62e-05	6	68	2	14660641
Pubmed	Endotoxin conditioning induces VCP/p97-mediated and inducible nitric-oxide synthase-dependent Tyr284 nitration in protein phosphatase 2A.	DUSP1 VCP	5.62e-05	6	68	2	20100830
Pubmed	Architecture of the linker-scaffold in the nuclear pore.	NUP155 NUP188	5.62e-05	6	68	2	35679425
Pubmed	Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B.	RRAGA RRAGB	5.62e-05	6	68	2	11073942
Pubmed	Regulation of TORC1 in response to amino acid starvation via lysosomal recruitment of TSC2.	RRAGA RRAGB	5.62e-05	6	68	2	24529380
Pubmed	Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases.	RRAGA RRAGB	5.62e-05	6	68	2	24081491
Pubmed	The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1.	RRAGA RRAGB	5.62e-05	6	68	2	18497260
Pubmed	Peering through the pore: nuclear pore complex structure, assembly, and function.	NUP155 NUP188 NUP160	5.74e-05	38	68	3	12791264
Pubmed	Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.	NUP155 NUP188 NUP160	6.71e-05	40	68	3	37516964
Pubmed	Sestrins function as guanine nucleotide dissociation inhibitors for Rag GTPases to control mTORC1 signaling.	RRAGA RRAGB	7.86e-05	7	68	2	25259925
Pubmed	Neurotrophic signaling in normal and degenerating rodent retinas.	PDE6B EIF2AK3	7.86e-05	7	68	2	11747369
Pubmed	Ragulator is a GEF for the rag GTPases that signal amino acid levels to mTORC1.	RRAGA RRAGB	1.05e-04	8	68	2	22980980
Pubmed	Expression of testicular germ cell genes identified by differential display analysis.	ANKRD18A ANKRD18B	1.05e-04	8	68	2	12634303
Pubmed	Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.	EIF2AK3 VCP	1.05e-04	8	68	2	22795130
Pubmed	Comparative genome mapping in the sequence-based era: early experience with human chromosome 7.	RASA4 RASA4B	1.05e-04	8	68	2	10810084
Pubmed	mRNA Processing Factor CstF-50 and Ubiquitin Escort Factor p97 Are BRCA1/BARD1 Cofactors Involved in Chromatin Remodeling during the DNA Damage Response.	BARD1 VCP	1.05e-04	8	68	2	29180510
Pubmed	Amino acid-dependent NPRL2 interaction with Raptor determines mTOR Complex 1 activation.	RRAGA RRAGB	1.05e-04	8	68	2	26582740
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	FBN2 NUP155 DUSP1 KCTD3 NUP188 ESPL1 ECM1 NUP160 VCP	1.15e-04	974	68	9	28675297
Pubmed	Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging.	RRAGA RRAGB	1.34e-04	9	68	2	24337580
Pubmed	p62 is a key regulator of nutrient sensing in the mTORC1 pathway.	RRAGA RRAGB	1.34e-04	9	68	2	21981924
Pubmed	Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway.	RRAGA RRAGB	1.68e-04	10	68	2	22424946
Pubmed	Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.	RRAGA RRAGB	2.05e-04	11	68	2	25567906
Pubmed	Reprogramming tumour-associated macrophages to outcompete cancer cells.	RRAGA RRAGB	2.05e-04	11	68	2	37380769
Pubmed	A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.	RRAGA RRAGB	2.05e-04	11	68	2	23723238
Pubmed	TTF-1/NKX2-1 binds to DDB1 and confers replication stress resistance to lung adenocarcinomas.	NUP155 NUP188 NUP160 VCP	2.30e-04	152	68	4	28192407
Pubmed	Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids.	RRAGA RRAGB	2.45e-04	12	68	2	20381137
Pubmed	SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1.	RRAGA RRAGB	2.45e-04	12	68	2	25561175
Pubmed	An ATM/TRIM37/NEMO Axis Counteracts Genotoxicity by Activating Nuclear-to-Cytoplasmic NF-κB Signaling.	NUP155 DOCK7	2.90e-04	13	68	2	30254148
Pubmed	Mechanism of Ubiquitination and Deubiquitination in the Fanconi Anemia Pathway.	FANCC USP1	2.90e-04	13	68	2	27986371
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	STIM2 NUP155 SYNE2 EIF2AK3 VCP	3.04e-04	299	68	5	37931956
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	GPBAR1 FBN2 ZNRF3 PHRF1 SIN3A NUP188 PPFIA3 P3H4 VCP	3.15e-04	1116	68	9	31753913
Pubmed	TBK1 Provides Context-Selective Support of the Activated AKT/mTOR Pathway in Lung Cancer.	RRAGA RRAGB	3.38e-04	14	68	2	28716898
Pubmed	The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.	FANCC USP1	3.89e-04	15	68	2	19536649
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	AKAP6 SYNE2 INTS4 USP1 NOTCH3 VCP	4.28e-04	497	68	6	23414517
Pubmed	Proteomic characterization of protein phosphatase 1 complexes in ischemia-reperfusion and ischemic tolerance.	PDE6B VCP	4.44e-04	16	68	2	17683050
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	STIM2 NUP155 RRAGA SYNE2 STK11IP EIF2AK3	4.60e-04	504	68	6	34432599
Pubmed	Probing nuclear pore complex architecture with proximity-dependent biotinylation.	NUP155 NUP188 NUP160	4.71e-04	77	68	3	24927568
Pubmed	A genome wide association study identifies common variants associated with lipid levels in the Chinese population.	DOCK7 USP1	5.03e-04	17	68	2	24386095
Pubmed	Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.	EIF2AK3 VCP	5.03e-04	17	68	2	32938586
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	ANKRD36B SYNE2 ANKRD36 NUP160	5.04e-04	187	68	4	26460568
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	CSRNP2 PHRF1 ZFYVE1	5.27e-04	80	68	3	19389623
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	STIM2 FBN2 RRAGA ECM1 LRP1B EIF2AK3 P3H4 NOTCH3 VCP	5.36e-04	1201	68	9	35696571
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FBN2 NUP155 DOCK7 SIN3A NUP188 NUP160 MED12 VCP CPSF7	5.42e-04	1203	68	9	29180619
Pubmed	PTEN counteracts FBXL2 to promote IP3R3- and Ca2+-mediated apoptosis limiting tumour growth.	FBXL19 VCP	5.65e-04	18	68	2	28614300
Pubmed	Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.	DOCK7 NUP160	5.65e-04	18	68	2	26598607
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	AKAP6 NUP155 PHRF1 NUP188 ESPL1 ZFYVE1	5.93e-04	529	68	6	14621295
Pubmed	Scanning the human proteome for calmodulin-binding proteins.	AKAP6 STIM2 SYNE2	7.93e-04	92	68	3	15840729
Pubmed	Protein interactome reveals converging molecular pathways among autism disorders.	ZNRF3 SIN3A ECM1 LRRC73 NOTCH3 VCP	7.98e-04	560	68	6	21653829
Pubmed	Identification of proteins interacting with protein arginine methyltransferase 8: the Ewing sarcoma (EWS) protein binds independent of its methylation state.	RASA4 SYNE2	9.28e-04	23	68	2	18320585
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	AKAP6 ZNRF3 SYNE2 PPFIA3	1.00e-03	225	68	4	12168954
Pubmed	The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling, Differentiation, and Metabolism of T Helper 1 and Follicular B Helper T Cells.	RASA4 RASA4B ESPL1 EIF2AK3	1.04e-03	227	68	4	26410627
Pubmed	Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV.	RHBDF2 ZNRF3 PCDHAC2 INTS4 NUP188 STK11IP P3H4 NOTCH3	1.07e-03	1061	68	8	33845483
Pubmed	Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.	NUP155 NUP160	1.10e-03	25	68	2	10601273
Pubmed	Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.	SIN3A NUP160 VCP	1.13e-03	104	68	3	26167872
Pubmed	Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.	NUP155 NUP160	1.19e-03	26	68	2	12228227
Pubmed	Adamts18 modulates the development of the aortic arch and common carotid artery.	FBN2 NOTCH3	1.19e-03	26	68	2	34189436
Pubmed	Laser capture microdissection and cDNA array analysis for identification of mouse KIAA/FLJ genes differentially expressed in the embryonic dorsal spinal cord.	PHRF1 PPFIA3	1.28e-03	27	68	2	19026994
Pubmed	Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.	NUP155 RRAGA DOCK7 CPSF7	1.29e-03	241	68	4	23125841
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	ARMC5 ESPL1 MED12 VCP	1.31e-03	242	68	4	34011540
Pubmed	TRRAP is essential for regulating the accumulation of mutant and wild-type p53 in lymphoma.	NUP155 VCP	1.38e-03	28	68	2	29653964
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RHBDF2 ZNRF3 LRRC14 NUP188 FBXL19 ESPL1 STK11IP MED12	1.39e-03	1105	68	8	35748872
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	NUP155 SIN3A NUP188 NUP160 VCP CPSF7	1.55e-03	638	68	6	33239621
Pubmed	p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation.	EDA NOTCH3	1.58e-03	30	68	2	16524929
Pubmed	FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis.	NUP155 CPSF7	1.69e-03	31	68	2	22323290
Pubmed	Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk.	FANCC USP1	1.69e-03	31	68	2	19690177
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	NUP155 NUP188 ESPL1 EIF2AK3 NUP160	1.72e-03	440	68	5	34244565
Pubmed	Proximity-dependent Mapping of the Androgen Receptor Identifies Kruppel-like Factor 4 as a Functional Partner.	INTS4 SIN3A MED12 CPSF7	1.91e-03	268	68	4	33640491
Pubmed	Characterization of long cDNA clones from human adult spleen.	ARMC5 ZSWIM4	1.91e-03	33	68	2	11214971
Pubmed	The endolysosomal adaptor PLEKHM1 is a direct target for both mTOR and MAPK pathways.	RRAGA RRAGB	1.91e-03	33	68	2	33452816
Pubmed	Genetic variation in genes interacting with BRCA1/2 and risk of breast cancer in the Cypriot population.	FANCC BARD1	1.91e-03	33	68	2	19714462
Pubmed	Atypical E2F repressors and activators coordinate placental development.	BARD1 ESPL1	1.91e-03	33	68	2	22516201
Cytoband	Ensembl 112 genes in cytogenetic band chr2q11	ANKRD36B TEKT4 ANKRD36 ANKRD36C	8.18e-05	153	68	4	chr2q11
Cytoband	8q24.3	TONSL ADGRB1 LRRC14	6.48e-04	113	68	3	8q24.3
Cytoband	2q11.1	TEKT4 ANKRD36C	7.97e-04	28	68	2	2q11.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	GPBAR1 BARD1 STK11IP	9.51e-04	129	68	3	chr2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr8q24	TONSL ADGRB1 LRRC14 OC90	1.94e-03	355	68	4	chr8q24
Cytoband	Ensembl 112 genes in cytogenetic band chr9p13	ANKRD18A ANKRD18B VCP	2.24e-03	174	68	3	chr9p13
Cytoband	1p31.3	DOCK7 USP1	2.63e-03	51	68	2	1p31.3
Cytoband	2q11.2	ANKRD36B ANKRD36	5.17e-03	72	68	2	2q11.2
Cytoband	9p13.3	ANKRD18B VCP	5.59e-03	75	68	2	9p13.3
Cytoband	2q35	GPBAR1 STK11IP	6.19e-03	79	68	2	2q35
GeneFamily	Ankyrin repeat domain containing	ANKRD36B TONSL BARD1 ANKRD18A ANKRD36 ANKRD36C TRPV5 ANKRD18B NOTCH3	1.53e-08	242	49	9	403
GeneFamily	Nucleoporins	NUP155 NUP188 NUP160	8.78e-05	32	49	3	1051
GeneFamily	Pleckstrin homology domain containing\|SH2 domain containing\|C2 and RasGAP domain containing	RASA4 RASA4B	3.19e-04	10	49	2	830
Coexpression	HE_LIM_SUN_FETAL_LUNG_C4_CYCLING_T_CELL	CISH ANKRD36B NUP155 SYNE2 BARD1 INTS4 ANKRD36 SIN3A NUP188 ANKRD36C ESPL1 USP1 NUP160	7.45e-07	939	68	13	M45768
ToppCell	3'_v3-Lung-Lymphocytic_T_CD4-T_CD4/CD8\|Lung / Manually curated celltypes from each tissue	ANKRD36B TARS3 SYNE2 ANKRD36 ANKRD36C	3.50e-06	151	68	5	999c11d19b61d6b130ad5e623afa83cbdfe13cdd
ToppCell	COVID-19_Moderate-multiplets\|World / disease group, cell group and cell class	ANKRD36B SYNE2 ANKRD18A ANKRD36 ANKRD36C	4.11e-06	156	68	5	afdc025fa75e7926b1cc182c4a33654a2186abb1
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	STIM2 SYNE2 ANKRD36 SIN3A ANKRD36C	1.21e-05	195	68	5	ed5f772c82d4dfd1c8735224446ec9feae3fb8c2
ToppCell	Bronchus_Control_(B.)\|World / Sample group, Lineage and Cell type	STIM2 IRAK2 ANKRD18A ANKRD36C ANKRD18B	1.27e-05	197	68	5	b6dff2ee108813e18657e2d8cf850e2423f8c8e9
Disease	angiopoietin-related protein 3 measurement	DOCK7 USP1	1.43e-05	3	65	2	EFO_0020148
Disease	1-palmitoyl-2-oleoyl-GPI (16:0/18:1) measurement	DOCK7 USP1	1.70e-04	9	65	2	EFO_0800439
Disease	protein CEI measurement	DOCK7 USP1	3.11e-04	12	65	2	EFO_0801936
Disease	level of Phosphatidylinositol (18:1_18:1) in blood serum	DOCK7 USP1	3.67e-04	13	65	2	OBA_2045159
Disease	Bone marrow hypocellularity	FANCC MYSM1	7.15e-04	18	65	2	C1855710
Disease	Adrenocortical carcinoma	ZNRF3 MED12	7.15e-04	18	65	2	C0206686
Disease	level of Phosphatidylcholine (16:0_18:2) in blood serum	DOCK7 USP1	8.85e-04	20	65	2	OBA_2045071
Disease	level of Phosphatidylinositol (18:0_20:4) in blood serum	DOCK7 USP1	1.17e-03	23	65	2	OBA_2045158
Disease	Pancytopenia	FANCC MYSM1	1.50e-03	26	65	2	C0030312

Protein segments in the cluster

Peptide	Gene	Start	Entry
LLLHRRCQIDICDRL	ANKRD18A	86	Q8IVF6
RCQIDICDRLNRTPL	ANKRD18A	91	Q8IVF6
LDRLEKLLRCSRCTN	BARD1	41	Q99728
ELRDLCCFLDSERQR	CCDC85B	76	Q15834
NGRCTIEERERSVCL	EIF2AK3	901	Q9NZJ5
TVPLDALRTRCLCDR	ADGRB1	911	O14514
QELRAIRLSREECGC	CSRNP2	201	Q9H175
DLAARNCLVDRDLCV	BMX	536	P51813
LLLDRKCQINICDRL	ANKRD18B	86	A2A2Z9
AVCLLCREAINRARL	ARMC5	351	Q96C12
VHLLVSRRCELNLCD	ANKRD36	81	A6QL64
SRRCELNLCDREDRT	ANKRD36	86	A6QL64
LLVSRRCELNLCDRE	ANKRD36B	71	Q8N2N9
RCELNLCDREDRTPL	ANKRD36B	76	Q8N2N9
LCRLVINRLVADVDC	CISH	226	Q9NSE2
RLDLRSCRQLSPEAC	FBXL19	656	Q6PCT2
RACRLRCSVLEARDL	RASA4	131	O43374
RACRLRCSVLEARDL	RASA4B	131	C9J798
DERCRVLISSLKDCL	CPSF7	386	Q8N684
RDIREALHELLCCTN	INTS4	461	Q96HW7
VHLLVSRRCELNLCD	ANKRD36C	81	Q5JPF3
SRRCELNLCDREDRT	ANKRD36C	86	Q5JPF3
RVNCSCRGDRILLED	LRP1B	2486	Q9NZR2
CRGDRILLEDNRCVT	LRP1B	2491	Q9NZR2
AEALATAACLCLRRR	IRAK2	471	O43187
PRCRLQCLRLEDCLA	NLRP8	786	Q86W28
LQDICRLERAVCRDE	GPBAR1	196	Q8TDU6
RAEVCQLRERLAVLC	PPFIA3	246	O75145
SQARLDAQCLLRRCI	SPATA18	311	Q8TC71
DAQCLLRRCIDKAET	SPATA18	316	Q8TC71
RRLCTLLQADRCSLF	PDE6B	81	P35913
RLCDIRSLPCREAAA	NOTCH3	1031	Q9UM47
CEVCGRSDREDRLLL	PHRF1	186	Q9P1Y6
REECRSLRSRCDQLE	L1RE1	101	Q9UN81
QDLRDRTCRACLEAL	LRRC14B	76	A6NHZ5
IARQCLLLEDLIRCA	MED12	1136	Q93074
DRCLAICQPLRSLRR	OXTR	136	P30559
ELRQLRCIDEFSTRC	ODF1	21	Q14990
CCLEQVRRLGCLLER	OC90	351	Q02509
VLNCERRRFTNLCLD	NUP155	1341	O75694
DREALCEQRPRCLLS	PCDHAC2	106	Q9Y5I4
LTLCCYLELRSELRR	EDA	56	Q92838
QRALCLLELTLEHCR	ESPL1	246	Q14674
ETEQCADLCLRLLRH	DOCK7	1546	Q96N67
LLGERAAQCLLLDCR	DUSP1	16	P28562
LISSERNCLRRIECF	FANCC	261	Q00597
ETLLLQAERRALCAC	C4orf48	76	Q5BLP8
LALIQLEREFQRCCR	ECM1	336	Q16610
RNCIDIDECLVNRLL	FBN2	806	P35556
LRDSFRSCELLLREC	SEC14L6	121	B5MCN3
RSCELLLRECELQSQ	SEC14L6	126	B5MCN3
EACLEELRRLCLREA	INAVA	131	Q3KP66
VRRLLLCEELERSSC	KCTD3	106	Q9Y597
QLRAENCDLRHRLCS	TARS3	56	A2RTX5
HRLCSLRLCLAEERS	TARS3	66	A2RTX5
EARDLLLGRFQCLRC	STK11IP	661	Q8N1F8
LLRLRCTENDGICLL	SYNE2	3426	Q8WXH0
ILCLRLLRICSQAER	SIN3A	901	Q96ST3
CRDARIRLLLAQCNA	SLC26A10	496	Q8NG04
DCILRDTSEDLRLQC	TEKT4	271	Q8WW24
LDCLRQLVVVLCERS	NUP160	1031	Q12769
LRLCQHLLDDRETCN	AKAP6	1141	Q13023
DLTEICQRACKLAIR	VCP	686	P55072
ACRLRELREGAECEL	STIM2	301	Q9P246
AAQLRELQLCSRRLC	TONSL	1331	Q96HA7
ELQLCSRRLCAEDRD	TONSL	1336	Q96HA7
CELRLFGRVLERAAC	P3H4	101	Q92791
EDLRRLSRPLECACF	RRAGA	146	Q7L523
CLRPLDIEFLQRLCR	SEPTIN12	171	Q8IYM1
EERTCILRCVLHLLT	NUP188	131	Q5SRE5
EEDLRRLSRPLECSC	RRAGB	206	Q5VZM2
QCLRCEEELHRQERL	ZFYVE1	41	Q9HBF4
EERALCCQARALLRP	ZNRF3	876	Q9ULT6
LVLRERDLERDSGCC	RHBDF2	486	Q6PJF5
LRTRCLECESLTERR	USP1	436	O94782
LRQLLLDCTCDVRQR	TRPV5	61	Q9NQA5
CRALLEACRLEEETL	ZSWIM4	421	Q9H7M6
SPLRLCCRDLRAEDL	LRRC14	191	Q15048
RLLSLRGCRLCDRDF	LRRC73	31	Q5JTD7
RRDSDLTCLQKLLEC	MYSM1	766	Q5VVJ2