Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serotonin-gated monoatomic cation channel activity	HTR3D HTR3C	2.81e-05	5	34	2	GO:0022850
GeneOntologyMolecularFunction	GTPase binding	OCRL DAAM1 GNB2 XPO6 FMNL1 RPTOR	2.89e-05	360	34	6	GO:0051020
GeneOntologyMolecularFunction	serotonin receptor activity	HTR3D HTR3C	4.20e-05	6	34	2	GO:0099589
GeneOntologyMolecularFunction	small GTPase binding	OCRL DAAM1 XPO6 FMNL1 RPTOR	1.97e-04	321	34	5	GO:0031267
GeneOntologyCellularComponent	serotonin receptor complex	HTR3D HTR3C	2.41e-05	5	33	2	GO:0098665
GeneOntologyCellularComponent	serotonin-activated cation-selective channel complex	HTR3D HTR3C	2.41e-05	5	33	2	GO:1904602
Domain	ARM-type_fold	PPP4R3B DAAM1 MEI1 DOCK8 XPO6 FMNL1 RPTOR	2.15e-06	339	34	7	IPR016024
Domain	ARM-like	PPP4R3B DAAM1 MEI1 DOCK8 XPO6 RPTOR	8.26e-06	270	34	6	IPR011989
Domain	DAD_dom	DAAM1 FMNL1	8.95e-05	8	34	2	IPR014767
Domain	DAD	DAAM1 FMNL1	8.95e-05	8	34	2	PS51231
Domain	Drf_GBD	DAAM1 FMNL1	1.15e-04	9	34	2	PF06371
Domain	FH3_dom	DAAM1 FMNL1	1.15e-04	9	34	2	IPR010472
Domain	GTPase-bd	DAAM1 FMNL1	1.15e-04	9	34	2	IPR010473
Domain	Drf_FH3	DAAM1 FMNL1	1.15e-04	9	34	2	PF06367
Domain	Drf_FH3	DAAM1 FMNL1	1.15e-04	9	34	2	SM01139
Domain	Drf_GBD	DAAM1 FMNL1	1.15e-04	9	34	2	SM01140
Domain	GBD/FH3_dom	DAAM1 FMNL1	1.75e-04	11	34	2	IPR014768
Domain	GBD_FH3	DAAM1 FMNL1	1.75e-04	11	34	2	PS51232
Domain	FH2	DAAM1 FMNL1	3.33e-04	15	34	2	PS51444
Domain	FH2_Formin	DAAM1 FMNL1	3.33e-04	15	34	2	IPR015425
Domain	FH2	DAAM1 FMNL1	3.33e-04	15	34	2	PF02181
Domain	FH2	DAAM1 FMNL1	3.33e-04	15	34	2	SM00498
Domain	Acetylcholine_rcpt_TM	HTR3D HTR3C	7.95e-04	23	34	2	IPR027361
Domain	-	HTR3D HTR3C	7.95e-04	23	34	2	1.20.120.370
Domain	Neur_chan_memb	HTR3D HTR3C	3.17e-03	46	34	2	PF02932
Domain	Neur_chan_LBD	HTR3D HTR3C	3.30e-03	47	34	2	PF02931
Domain	Neur_channel	HTR3D HTR3C	3.30e-03	47	34	2	IPR006201
Domain	Neur_chan_lig-bd	HTR3D HTR3C	3.30e-03	47	34	2	IPR006202
Domain	NEUROTR_ION_CHANNEL	HTR3D HTR3C	3.30e-03	47	34	2	PS00236
Domain	Neurotrans-gated_channel_TM	HTR3D HTR3C	3.30e-03	47	34	2	IPR006029
Domain	-	HTR3D HTR3C	3.30e-03	47	34	2	2.70.170.10
Domain	-	DAAM1 XPO6 RPTOR	7.56e-03	222	34	3	1.25.10.10
Pubmed	Primary cilia signaling mediates intraocular pressure sensation.	TRPV4 OCRL	9.84e-07	2	35	2	25143588
Pubmed	Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E.	HTR3D HTR3C	2.95e-06	3	35	2	21192076
Pubmed	Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E.	HTR3D HTR3C	2.95e-06	3	35	2	12801637
Pubmed	A cluster of novel serotonin receptor 3-like genes on human chromosome 3.	HTR3D HTR3C	5.90e-06	4	35	2	14597179
Pubmed	Genetic Association of the PARL-ABCC5-HTR3D-HTR3C Locus With Primary Angle-Closure Glaucoma in Chinese.	HTR3D HTR3C	5.90e-06	4	35	2	28813580
Pubmed	ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.	HTR3D HTR3C	5.90e-06	4	35	2	24603532
Pubmed	A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.	HTR3D HTR3C	9.82e-06	5	35	2	20356718
Pubmed	Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E.	HTR3D HTR3C	9.82e-06	5	35	2	17392525
Pubmed	Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.	HTR3D HTR3C	9.82e-06	5	35	2	19794330
Pubmed	Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.	HTR3D HTR3C	1.47e-05	6	35	2	20021265
Pubmed	Gβγ interacts with mTOR and promotes its activation.	GNB2 RPTOR	2.74e-05	8	35	2	24462769
Pubmed	Pitx1 determines the morphology of muscle, tendon, and bones of the hindlimb.	HOXC10 HAND2	4.40e-05	10	35	2	16989801
Pubmed	Expression of multiple formins in adult tissues and during developmental stages of mouse brain.	DAAM1 FMNL1	8.89e-05	14	35	2	26272686
Pubmed	Pitx1 and Pitx2 are required for development of hindlimb buds.	HOXC10 HAND2	1.49e-04	18	35	2	12441290
Pubmed	A mega-analysis of genome-wide association studies for major depressive disorder.	HTR3D HTR3C	1.66e-04	19	35	2	22472876
Pubmed	Switching axial progenitors from producing trunk to tail tissues in vertebrate embryos.	HOXC10 HAND2	1.66e-04	19	35	2	23763947
Pubmed	Oct4 Is a Key Regulator of Vertebrate Trunk Length Diversity.	HOXC10 HAND2	1.66e-04	19	35	2	27453501
Pubmed	Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system.	LAMA2 RPTOR	2.04e-04	21	35	2	28880149
Pubmed	HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure.	HAND2 PPM1L	2.24e-04	22	35	2	31286141
Pubmed	Sall4-Gli3 system in early limb progenitors is essential for the development of limb skeletal elements.	HOXC10 HAND2	2.91e-04	25	35	2	25848055
Pubmed	Islet1 regulates establishment of the posterior hindlimb field upstream of the Hand2-Shh morphoregulatory gene network in mouse embryos.	HOXC10 HAND2	2.91e-04	25	35	2	22438573
Pubmed	CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment.	DYRK1A PPP4R3B GNB2 NUP107 RPTOR	3.33e-04	606	35	5	36538041
Pubmed	Compartment-dependent activities of Wnt3a/β-catenin signaling during vertebrate axial extension.	HOXC10 HAND2	3.40e-04	27	35	2	25152336
Pubmed	SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development.	HOXC10 HAND2	3.40e-04	27	35	2	20417598
Pubmed	Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration.	ZNF135 FMNL1	3.93e-04	29	35	2	21834987
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	OSBPL9 DYRK1A OGDHL GNB2 DOCK8 ADAM22 RPTOR	4.81e-04	1431	35	7	37142655
Pubmed	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.	PPP4R3B SEMA6A RPTOR	4.93e-04	153	35	3	10718198
Pubmed	The SRCAP chromatin remodeling complex promotes oxidative metabolism during prenatal heart development.	OGDHL HAND2	6.76e-04	38	35	2	33913477
Pubmed	F-box only protein 9 is an E3 ubiquitin ligase of PPARγ.	HTR3D ADAM22	7.49e-04	40	35	2	27197753
Pubmed	The microRNA-processing enzyme Dicer is dispensable for somite segmentation but essential for limb bud positioning.	HOXC10 HAND2	7.49e-04	40	35	2	21256124
Pubmed	The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety.	HOXC10 GNB2	8.66e-04	43	35	2	26487511
Interaction	DIAPH1 interactions	PPP4R3B DAAM1 XPO6 FMNL1 ZNF284	1.26e-05	176	35	5	int:DIAPH1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	HTR3D HTR3C LIPH	1.30e-04	128	35	3	chr3q27
Cytoband	3q27.1	HTR3D HTR3C	1.96e-04	27	35	2	3q27.1
GeneFamily	5-hydroxytryptamine receptors, ionotropic	HTR3D HTR3C	1.68e-05	5	24	2	172
Coexpression	GSE22935_UNSTIM_VS_48H_MBOVIS_BCG_STIM_MACROPHAGE_DN	DYRK1A FRY MGAT4B KATNA1 PPM1L	5.58e-06	199	34	5	M7779

Protein segments in the cluster

Peptide	Gene	Start	Entry
LITLREFMKYRRDFI	ADAM22	306	Q9P0K1
LFRLYLLFMASSILT	HTR3C	426	Q8WXA8
LVFEMLSYNLYDLLR	DYRK1A	236	Q13627
LLRFMTHLILFFRTL	NUP107	546	P57740
FILERRSLLEMYADF	OSBPL9	396	Q96SU4
DRRLDFTEFLLMIFK	FLG2	66	Q5D862
DLSLIVEFILMFYRD	MGAT4B	311	Q9UQ53
LLARLVRSMRFEDFL	OGDHL	241	Q9ULD0
RLFDLRADQELLMYS	GNB2	251	P62879
LLMYLATRDLRDFMS	LAMA2	2376	P24043
MLRFYLFISLLCLSR	LIPH	1	Q8WWY8
LRFMRRIIGLKDEFY	PPP4R3B	591	Q5MIZ7
LLLRFFLLYPELMSR	MEI1	781	Q5TIA1
LRLATSYIAYLMDLL	HAND2	141	P61296
ESLDFRLHLRYEFLM	DAAM1	296	Q9Y4D1
SLAFFLYDLLSLMDR	DOCK8	1051	Q8NF50
DKDRRLLLSLLSMFY	DNAH3	3741	Q8TD57
EFLFNMYLTRERRLE	HOXC10	286	Q9NYD6
LDFLELLMRFLPTEY	FMNL1	746	O95466
SEKLVRLLFEMARFY	KATNA1	286	O75449
DYLMERRDLAIDFIF	FRY	161	Q5TBA9
FEFEYLMALRLLSRL	FRY	2056	Q5TBA9
MFLSEDENFLLLFRR	SCGN	86	O76038
DLEVRDYYLSLLLML	RGSL1	121	A5PLK6
MRYFLLRPETLFLLC	PPM1L	16	Q5SGD2
FIRSMAAYSLLLFLL	PI4KAP2	426	A4QPH2
FRYLMAFLRELLKFS	OCRL	836	Q01968
LFRNFLLAERIMRSY	RPTOR	346	Q8N122
ALLFRLYLLFMASSI	HTR3D	431	Q70Z44
RTLYRDVMLDTFRLL	ZNF135	36	P52742
MRSEALLLYFTLLHF	SEMA6A	1	Q9H2E6
LLLVALDRMEYVRTF	TMEM121	126	Q9BTD3
FMRELRYLFALLVGT	USP25	221	Q9UHP3
DEMLSFFLTLFRGLR	XPO6	836	Q96QU8
FKDLFRFLLVYLLFM	TRPV4	611	Q9HBA0
YERRLNLDMILSLFL	ZNF284	576	Q2VY69