Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Homeobox_antennapedia	HOXB4 HOXC4	2.23e-04	12	35	2	IPR017995
Domain	Homeobox_Antennapedia_CS	HOXB4 HOXC4	7.01e-04	21	35	2	IPR001827
Domain	ANTENNAPEDIA	HOXB4 HOXC4	9.18e-04	24	35	2	PS00032
Domain	SET	SETD1A PRDM2	2.67e-03	41	35	2	PF00856
Domain	SET	SETD1A PRDM2	3.35e-03	46	35	2	SM00317
Domain	SET_dom	SETD1A PRDM2	3.95e-03	50	35	2	IPR001214
Domain	SET	SETD1A PRDM2	3.95e-03	50	35	2	PS50280
Domain	RRM_1	SETD1A MSI1 SPEN	6.85e-03	208	35	3	PF00076
Domain	RRM	SETD1A MSI1 SPEN	7.70e-03	217	35	3	SM00360
Domain	RRM_dom	SETD1A MSI1 SPEN	8.71e-03	227	35	3	IPR000504
Domain	RRM	SETD1A MSI1 SPEN	9.02e-03	230	35	3	PS50102
Domain	-	SETD1A MSI1 SPEN	1.06e-02	244	35	3	3.30.70.330
Domain	Nucleotide-bd_a/b_plait	SETD1A MSI1 SPEN	1.23e-02	258	35	3	IPR012677
Domain	Homeobox_metazoa	HOXB4 HOXC4	1.23e-02	90	35	2	IPR020479
Pubmed	HOXC4 homeoprotein efficiently expands human hematopoietic stem cells and triggers similar molecular alterations as HOXB4.	HOXB4 HOXC4	1.29e-06	2	40	2	22298821
Pubmed	Tuberous sclerosis complex-mediated mTORC1 overactivation promotes age-related hearing loss.	TSC1 ATOH1	1.29e-05	5	40	2	30247156
Pubmed	Sequence and embryonic expression of the murine Hox-3.5 gene.	HOXB4 HOXC4	2.70e-05	7	40	2	1363091
Pubmed	Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations.	HOXB4 HOXC4	2.70e-05	7	40	2	8660891
Pubmed	Hox genes regulate the onset of Tbx5 expression in the forelimb.	HOXB4 HOXC4	3.60e-05	8	40	2	22872086
Pubmed	Region-specific gastrointestinal Hox code during murine embryonal gut development.	HOXB4 HOXC4	4.62e-05	9	40	2	11869294
Pubmed	Coordinated expression of 3' hox genes during murine embryonal gut development: an enteric Hox code.	HOXB4 HOXC4	4.62e-05	9	40	2	10579975
Pubmed	Interaction network of human early embryonic transcription factors.	BCL9L SETD1A TBKBP1 SPEN PRDM2	5.01e-05	351	40	5	38297188
Pubmed	Expression of class I homeobox genes in fetal and adult murine skin.	HOXB4 HOXC4	8.45e-05	12	40	2	8105001
Pubmed	Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.	HOXB4 ATOH1	1.16e-04	14	40	2	16364898
Pubmed	A distinct Hox code for the branchial region of the vertebrate head.	HOXB4 HOXC4	1.34e-04	15	40	2	1682814
Pubmed	Hox genes and the evolution of vertebrate axial morphology.	HOXB4 HOXC4	1.53e-04	16	40	2	7768176
Pubmed	Human transcription factor protein interaction networks.	MRPL10 BCL9L SETD1A ARHGAP32 TADA1 SRCAP SPEN PRDM2	1.89e-04	1429	40	8	35140242
Pubmed	Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice.	HOXB4 HOXC4	1.95e-04	18	40	2	9639506
Pubmed	The contribution of de novo coding mutations to autism spectrum disorder.	SRCAP SPEN	1.95e-04	18	40	2	25363768
Pubmed	The mouse PcG gene eed is required for Hox gene repression and extraembryonic development.	HOXB4 HOXC4	2.42e-04	20	40	2	12370779
Pubmed	Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.	HOXB4 HOXC4	2.67e-04	21	40	2	30254164
Pubmed	Crypto-rhombomeres of the mouse medulla oblongata, defined by molecular and morphological features.	HOXB4 HOXC4	2.67e-04	21	40	2	25381007
Pubmed	Organization of human class I homeobox genes.	HOXB4 HOXC4	2.94e-04	22	40	2	2576652
Pubmed	Cdx is crucial for the timing mechanism driving colinear Hox activation and defines a trunk segment in the Hox cluster topology.	HOXB4 HOXC4	3.21e-04	23	40	2	28041967
Pubmed	A dynamic expression survey identifies transcription factors relevant in mouse digestive tract development.	HOXB4 HOXC4 ATOH1	3.43e-04	118	40	3	16971476
Pubmed	Targeted disruption of the mouse homologue of the Drosophila polyhomeotic gene leads to altered anteroposterior patterning and neural crest defects.	HOXB4 HOXC4	3.50e-04	24	40	2	9367423
Pubmed	BioID identifies novel c-MYC interacting partners in cultured cells and xenograft tumors.	SETD1A TADA1 SPEN	4.98e-04	134	40	3	25452129
Pubmed	The human HOX gene family.	HOXB4 HOXC4	5.13e-04	29	40	2	2574852
Pubmed	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	SETD1A IGF2-AS TSC1	5.66e-04	140	40	3	20819778
Pubmed	The zinc-finger transcription factor GLI3 is a regulator of precerebellar neuronal migration.	HOXB4 ATOH1	5.87e-04	31	40	2	30470704
Pubmed	Sf3b4 regulates chromatin remodeler splicing and Hox expression.	HOXB4 HOXC4	6.26e-04	32	40	2	37167859
Pubmed	A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs.	TADA1 SRCAP	7.49e-04	35	40	2	20946988
Pubmed	Transcriptome analysis of mouse stem cells and early embryos.	KCP FGD1 ARHGAP32 SRCAP	7.93e-04	363	40	4	14691545
Pubmed	Identification of 10 murine homeobox genes.	HOXB4 HOXC4	8.83e-04	38	40	2	1683707
Pubmed	Atlas of Hox gene expression in the developing kidney.	HOXB4 HOXC4	8.83e-04	38	40	2	15042701
Pubmed	Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster.	HOXB4 HOXC4	9.30e-04	39	40	2	33257809
Pubmed	Quantification of Hox and surfactant protein-B transcription during murine lung development.	HOXB4 HOXC4	9.79e-04	40	40	2	19204410
Pubmed	Lin28a/let-7 pathway modulates the Hox code via Polycomb regulation during axial patterning in vertebrates.	HOXB4 HOXC4	1.03e-03	41	40	2	32479258
Pubmed	Reduction of Hox gene expression by histone H1 depletion.	HOXB4 HOXC4	1.13e-03	43	40	2	22701719
Cytoband	Ensembl 112 genes in cytogenetic band chr17q21	MRPL10 HOXB4 TBKBP1 ZNF385C ACBD4 GJD3	3.31e-06	473	40	6	chr17q21
Cytoband	17q21.32	MRPL10 HOXB4 TBKBP1	1.10e-05	49	40	3	17q21.32
Cytoband	9q34.3	ARRDC1 AJM1 LRRC26	1.11e-04	106	40	3	9q34.3
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	TSC1 ARRDC1 AJM1 LRRC26	1.84e-04	325	40	4	chr9q34
Cytoband	17q21.2	ZNF385C GJD3	1.72e-03	70	40	2	17q21.2
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETD1A PRDM2	6.38e-04	34	20	2	487
GeneFamily	HOXL subclass homeoboxes	HOXB4 HOXC4	1.49e-03	52	20	2	518
GeneFamily	RNA binding motif containing	SETD1A MSI1 SPEN	1.59e-03	213	20	3	725
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCP SETD1A TADA1 GPC3	1.27e-05	160	40	4	a76ad44b5f25f59d6b9333fb45f8bb96196a3090
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCP SETD1A TADA1 GPC3	1.27e-05	160	40	4	af84da18c85037f49f55e8958f00f12140226982
ToppCell	3'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCP SETD1A TADA1 GPC3	1.27e-05	160	40	4	f7ca98beaa24f9674d503588eb15d341c4135d77
ToppCell	3'-GW_trimst-1-SmallIntestine-Epithelial-mature_enterocytic-Paneth\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATOH1 FAM181B AJM1 LRRC26	1.77e-05	174	40	4	b4483d7d9f22f09ed7fa0b72305434a47ccaade0
ToppCell	severe-Lymphocytic-CD8_T_cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	MRPL10 BCL9L RTL6 PRR5L	2.82e-05	196	40	4	d83acd9abd7b296989b8ae09da63799e6877a149
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_submucosal-gland-SMG_Duct\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TSC1 ACBD4 DYRK1B LRRC26	3.05e-05	200	40	4	1b527bebbca1ef8c52449e40beb9358e37494e04
Disease	anti-human herpes virus 7 antibody measurement	BCL9L TBKBP1	1.29e-05	5	34	2	EFO_0011038
Disease	leukemia (implicated_via_orthology)	HOXB4 HOXC4	2.18e-04	19	34	2	DOID:1240 (implicated_via_orthology)
Disease	multiple sclerosis	KCP USP31 SETD1A PRR5L TBKBP1	5.58e-04	594	34	5	MONDO_0005301
Disease	Eczema	PRR5L ACBD4 ARRDC1	5.40e-03	310	34	3	HP_0000964
Disease	Epilepsy	SETD1A TSC1	7.02e-03	109	34	2	C0014544
Disease	brain aneurysm	ARHGAP32 PRDM2	7.53e-03	113	34	2	EFO_0003870

Protein segments in the cluster

Peptide	Gene	Start	Entry
QPPPTPDPTCREPAH	ZNF385C	156	Q66K41
ACHDNGRASPPPPPA	AGBL5	531	Q8NDL9
PHYPLAQGDSPPPCP	CCDC185	136	Q8N715
PCLPKEPAPPSPESH	ACBD4	156	Q8NC06
CAPPEPPAGPAPHVR	AJM1	171	C9J069
PPACSQHTPPLPSTP	C3orf36	86	Q3SXR2
GPADCSPPHPAPAPQ	DYRK1B	571	Q9Y463
PEPCPQDGSPASHPL	ARRDC1	356	Q8N5I2
PPPPPPDATCHQVRS	GPC3	26	P51654
PCPQAPSQHPPSPPK	MAP3K6	946	O95382
ASSGPCSPAAPHPPP	FAM83A	351	Q86UY5
FFPDCALPPPPPPHQ	FAM181B	376	A6NEQ2
SVPAHPCGFPAPLPP	ARHGAP32	1401	A7KAX9
PQPGLASPDSPHDPC	MSI1	6	O43347
GDLAAPPPPAPCFSH	KCNJ14	116	Q9UNX9
PPSFPPPHRQCSSEP	PRR5L	326	Q6MZQ0
SPPPPPCAQNPLHPS	HOXB4	116	P17483
AASPQPCPAPHAGLP	IGF2-AS	21	Q6U949
SPAPPACSQPAPDHP	HOXC4	111	P09017
GEQPPPPPASCKSDH	ATOH1	221	Q92858
SPPLSPRGHCPPAPA	BCL9L	21	Q86UU0
GPEPCAPPAYAHPAP	GJD3	256	Q8N144
LPAGFTPDTPHPPCP	FAM166A	126	Q6J272
PAPSSSASPHPCPSP	PRDM2	996	Q13029
PCPVHPASNGTSPAP	RTL6	216	Q6ICC9
PPDHTSDPPSPCGSP	SAP25	166	Q8TEE9
TAPCAGQNPASHPPP	TADA1	236	Q96BN2
PPAPCQHPTQPPGAC	KCP	466	Q6ZWJ8
EHPATNPPGAAPPAC	FGD1	16	P98174
AHPDNACSPIAPPPP	RNF167	61	Q9H6Y7
PPQPPQASPPAAADH	SMCR5	51	Q8TEV8
HTPDPLACSPPPPKG	SPATA31C1	221	P0DKV0
TPPPAHTPPPAQTCL	SRCAP	2506	Q6ZRS2
HGPCTPPPAPANFED	SETD1A	536	O15047
APPEPPHNLFCAPGS	SERTAD3	166	Q9UJW9
PATSPPPAPLCHSDD	TSC1	391	Q92574
PVSAAPCLHEAPPPP	SPEN	2561	Q96T58
HPSCLPSPPSPPQEE	MRPL10	61	Q7Z7H8
PASPAPPACAAEPVP	USP31	111	Q70CQ4
HSPAPQCPSPSPPAR	TBKBP1	341	A7MCY6
NPDPDPHGCASPADP	LRRC26	311	Q2I0M4