Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	transmembrane transporter activity	ABCG4 ABCC3 ABCG1 SLC38A10 SLC46A3 ABCA4 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 SLC5A2 SLC16A10	1.16e-11	1180	66	22	GO:0022857
GeneOntologyMolecularFunction	transporter activity	ABCG4 ABCC3 ABCG1 SLC38A10 SLC46A3 ABCA4 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 SLC5A2 SLC16A10	6.45e-11	1289	66	22	GO:0005215
GeneOntologyMolecularFunction	active transmembrane transporter activity	ABCG4 ABCC3 ABCG1 SLC46A3 ABCA4 SLC4A8 SLC6A17 KCNJ11 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC5A2 SLC16A10	4.06e-10	477	66	14	GO:0022804
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	SLC46A3 SLC4A8 HCN4 KCNJ11 SLC6A15 CACNA1H CACNA1G SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 SLC5A2	3.33e-09	465	66	13	GO:0046873
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC4A8 HCN4 SLC6A15 CACNA1H CACNA1G SLC1A1 SLC38A3 SLC9A6 SLC5A2	4.88e-09	171	66	9	GO:0015081
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	ABCC3 SLC46A3 SLC4A8 HCN4 KCNJ11 SLC6A15 CACNA1H CACNA1G MFSD8 SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 SLC5A2	1.89e-08	758	66	15	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	SLC46A3 SLC4A8 HCN4 KCNJ11 SLC6A15 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 SLC5A2	3.43e-08	793	66	15	GO:0015075
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	SLC46A3 SLC4A8 HCN4 KCNJ11 SLC6A15 CACNA1H CACNA1G SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 SLC5A2	1.13e-07	627	66	13	GO:0022890
GeneOntologyMolecularFunction	MHC class Ib protein binding	KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1	1.92e-07	16	66	4	GO:0023029
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	SLC46A3 SLC4A8 HCN4 KCNJ11 SLC6A15 CACNA1H CACNA1G SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 SLC5A2	2.18e-07	664	66	13	GO:0008324
GeneOntologyMolecularFunction	MHC class Ib receptor activity	KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1	4.06e-07	19	66	4	GO:0032394
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC46A3 SLC4A8 SLC6A17 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC5A2 SLC16A10	5.41e-07	296	66	9	GO:0015291
GeneOntologyMolecularFunction	symporter activity	SLC46A3 SLC4A8 SLC6A17 SLC6A15 SLC1A1 SLC38A3 SLC5A2	6.30e-07	150	66	7	GO:0015293
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8H2 SEMA4D OR7G1 OR51M1 OR51I2 OR52H1 GPR173 KIR3DL3 OR14J1 KIR2DS2 SMIM17 KIR2DL3 OR56A1 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.27e-06	1353	66	17	GO:0004888
GeneOntologyMolecularFunction	ATPase-coupled lipid transmembrane transporter activity	ABCG4 ABCC3 ABCG1	2.86e-06	9	66	3	GO:0034040
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC4A8 SLC6A15 SLC1A1 SLC38A3 SLC5A2	7.14e-06	81	66	5	GO:0015370
GeneOntologyMolecularFunction	ABC-type sterol transporter activity	ABCG4 ABCG1	1.08e-05	2	66	2	GO:0034041
GeneOntologyMolecularFunction	immune receptor activity	KIR3DL3 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.75e-05	165	66	6	GO:0140375
GeneOntologyMolecularFunction	monoatomic ion channel activity	HCN4 KCNJ11 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5	1.92e-05	459	66	9	GO:0005216
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCG4 ABCC3 ABCG1 ABCA4	2.06e-05	49	66	4	GO:0140359
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC38A10 SLC6A15 SLC1A1 SLC38A3 SLC16A10	2.53e-05	105	66	5	GO:0015171
GeneOntologyMolecularFunction	MHC class I receptor activity	KIR2DS5 KIR3DL1 KIR3DS1	2.72e-05	18	66	3	GO:0032393
GeneOntologyMolecularFunction	ATPase-coupled transmembrane transporter activity	ABCG4 ABCC3 ABCG1 ABCA4 KCNJ11	3.03e-05	109	66	5	GO:0042626
GeneOntologyMolecularFunction	low voltage-gated calcium channel activity	CACNA1H CACNA1G	3.22e-05	3	66	2	GO:0008332
GeneOntologyMolecularFunction	MHC protein binding	KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1	4.04e-05	58	66	4	GO:0042287
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC4A8 SLC6A15 SLC1A1 SLC38A3 SLC5A2	4.62e-05	119	66	5	GO:0015294
GeneOntologyMolecularFunction	organic anion transmembrane transporter activity	ABCC3 SLC38A10 SLC4A8 SLC6A15 SLC1A1 SLC38A3 SLC16A10	5.06e-05	293	66	7	GO:0008514
GeneOntologyMolecularFunction	channel activity	HCN4 KCNJ11 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5	5.47e-05	525	66	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	HCN4 KCNJ11 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5	5.56e-05	526	66	9	GO:0022803
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC6A15 SLC1A1 SLC38A3	5.83e-05	23	66	3	GO:0005283
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC4A8 KCNJ11 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC5A2	6.00e-05	301	66	7	GO:0022853
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	ABCC3 SLC38A10 SLC6A15 SLC1A1 SLC38A3 SLC16A10	6.25e-05	207	66	6	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	ABCC3 SLC38A10 SLC6A15 SLC1A1 SLC38A3 SLC16A10	6.42e-05	208	66	6	GO:0005342
GeneOntologyMolecularFunction	organic hydroxy compound transmembrane transporter activity	ABCG4 ABCC3 ABCG1 ABCA4	8.47e-05	70	66	4	GO:1901618
GeneOntologyMolecularFunction	olfactory receptor activity	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1	8.48e-05	431	66	8	GO:0004984
GeneOntologyMolecularFunction	voltage-gated sodium channel activity	HCN4 CACNA1H CACNA1G	8.49e-05	26	66	3	GO:0005248
GeneOntologyMolecularFunction	L-amino acid transmembrane transporter activity	SLC38A10 SLC1A1 SLC38A3 SLC16A10	8.95e-05	71	66	4	GO:0015179
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	ABCG4 ABCC3 ABCG1 ABCA4	9.98e-05	73	66	4	GO:0170055
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A15 SLC1A1 SLC38A3	1.19e-04	29	66	3	GO:0005416
GeneOntologyMolecularFunction	neutral L-amino acid:sodium symporter activity	SLC6A15 SLC38A3	2.97e-04	8	66	2	GO:0005295
GeneOntologyMolecularFunction	primary active transmembrane transporter activity	ABCG4 ABCC3 ABCG1 ABCA4 KCNJ11	3.06e-04	178	66	5	GO:0015399
GeneOntologyMolecularFunction	neutral L-amino acid transmembrane transporter activity	SLC6A15 SLC1A1 SLC38A3	3.36e-04	41	66	3	GO:0015175
GeneOntologyMolecularFunction	metal cation:monoatomic cation antiporter activity	SLC4A8 SLC38A3 SLC9A6	3.87e-04	43	66	3	GO:0140828
GeneOntologyMolecularFunction	intracellularly cAMP-activated cation channel activity	HCN4 CNGA4	4.76e-04	10	66	2	GO:0005222
GeneOntologyMolecularFunction	sodium channel activity	HCN4 CACNA1H CACNA1G	6.79e-04	52	66	3	GO:0005272
GeneOntologyMolecularFunction	inhibitory MHC class I receptor activity	KIR2DS5 KIR3DL1	6.95e-04	12	66	2	GO:0032396
GeneOntologyMolecularFunction	intracellularly cyclic nucleotide-activated monoatomic cation channel activity	HCN4 CNGA4	8.20e-04	13	66	2	GO:0005221
GeneOntologyMolecularFunction	cyclic nucleotide-activated monoatomic ion channel activity	HCN4 CNGA4	8.20e-04	13	66	2	GO:0043855
GeneOntologyMolecularFunction	aromatic amino acid transmembrane transporter activity	SLC38A3 SLC16A10	8.20e-04	13	66	2	GO:0015173
GeneOntologyMolecularFunction	calcium channel activity	CACNA1H CACNA1G CNGA4 TRPV5	8.79e-04	129	66	4	GO:0005262
GeneOntologyMolecularFunction	monoatomic cation channel activity	HCN4 KCNJ11 CACNA1H CACNA1G CNGA4 TRPV5	9.39e-04	343	66	6	GO:0005261
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1H CACNA1G	9.54e-04	14	66	2	GO:0008331
GeneOntologyMolecularFunction	sodium:proton antiporter activity	SLC38A3 SLC9A6	1.25e-03	16	66	2	GO:0015385
GeneOntologyMolecularFunction	monoatomic anion transmembrane transporter activity	SLC4A8 MFSD8 LRRC8D SLC1A1	1.57e-03	151	66	4	GO:0008509
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1H CACNA1G CNGA4 TRPV5	1.57e-03	151	66	4	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	HCN4 KCNJ11 CACNA1H CACNA1G	1.61e-03	152	66	4	GO:0022843
GeneOntologyMolecularFunction	inorganic anion transmembrane transporter activity	ABCC3 SLC4A8 MFSD8 SLC1A1	2.48e-03	171	66	4	GO:0015103
GeneOntologyMolecularFunction	organic cation transmembrane transporter activity	SLC1A1 SLC38A3 SLC16A10	2.62e-03	83	66	3	GO:0015101
GeneOntologyMolecularFunction	cAMP binding	HCN4 CNGA4	3.07e-03	25	66	2	GO:0030552
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	HCN4 KCNJ11 CACNA1H CACNA1G	3.10e-03	182	66	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	HCN4 KCNJ11 CACNA1H CACNA1G	3.22e-03	184	66	4	GO:0022832
GeneOntologyMolecularFunction	metal cation:proton antiporter activity	SLC38A3 SLC9A6	3.58e-03	27	66	2	GO:0051139
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	ABCG1 ABCA4	3.85e-03	28	66	2	GO:0140326
GeneOntologyMolecularFunction	lipid transporter activity	ABCG4 ABCC3 ABCG1 ABCA4	4.04e-03	196	66	4	GO:0005319
GeneOntologyMolecularFunction	monoatomic anion channel activity	MFSD8 LRRC8D SLC1A1	4.82e-03	103	66	3	GO:0005253
GeneOntologyMolecularFunction	gated channel activity	HCN4 KCNJ11 CACNA1H CACNA1G CNGA4	4.93e-03	334	66	5	GO:0022836
GeneOntologyMolecularFunction	serine-type endopeptidase inhibitor activity	HMSD SERPINI1 CD109	5.09e-03	105	66	3	GO:0004867
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	HCN4 CNGA4	5.32e-03	33	66	2	GO:0005217
GeneOntologyMolecularFunction	organic acid:sodium symporter activity	SLC6A15 SLC1A1	5.97e-03	35	66	2	GO:0005343
GeneOntologyMolecularFunction	cyclic nucleotide binding	HCN4 CNGA4	7.37e-03	39	66	2	GO:0030551
GeneOntologyMolecularFunction	chloride transmembrane transporter activity	SLC4A8 MFSD8 SLC1A1	8.23e-03	125	66	3	GO:0015108
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 GPR173 OR14J1 OR56A1	8.47e-03	884	66	8	GO:0004930
GeneOntologyBiologicalProcess	import across plasma membrane	HCN4 KCNJ11 CACNA1H CACNA1G LRRC8D SLC1A1 TRPV5 SLC38A3 SLC9A6 SLC5A2	4.68e-09	230	69	10	GO:0098739
GeneOntologyBiologicalProcess	sodium ion transport	SLC4A8 HCN4 SLC6A17 SLC6A15 CACNA1H CACNA1G CNGA4 SLC38A3 SLC9A6 SLC5A2	2.56e-08	275	69	10	GO:0006814
GeneOntologyBiologicalProcess	monoatomic ion transport	TMX1 ABCC3 SLC46A3 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 HTT SLC5A2	7.35e-08	1374	69	19	GO:0006811
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	ABCC3 SLC46A3 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G MFSD8 LRRC8D SLC1A1 CNGA4 TRPV5 SLC9A6 HTT SLC5A2	1.05e-07	1115	69	17	GO:0034220
GeneOntologyBiologicalProcess	immune response-regulating signaling pathway	KIR2DL5B PIK3CA KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1 TLR8 EPG5	1.08e-07	615	69	13	GO:0002764
GeneOntologyBiologicalProcess	metal ion transport	TMX1 SLC46A3 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 HTT SLC5A2	1.40e-07	1000	69	16	GO:0030001
GeneOntologyBiologicalProcess	sodium ion transmembrane transport	SLC4A8 HCN4 SLC6A17 SLC6A15 CACNA1H CACNA1G SLC9A6 SLC5A2	4.61e-07	208	69	8	GO:0035725
GeneOntologyBiologicalProcess	inorganic ion import across plasma membrane	HCN4 KCNJ11 CACNA1H CACNA1G TRPV5 SLC9A6 SLC5A2	4.77e-07	142	69	7	GO:0099587
GeneOntologyBiologicalProcess	inorganic cation import across plasma membrane	HCN4 KCNJ11 CACNA1H CACNA1G TRPV5 SLC9A6 SLC5A2	4.77e-07	142	69	7	GO:0098659
GeneOntologyBiologicalProcess	monoatomic cation transport	TMX1 SLC46A3 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G SLC1A1 CNGA4 TRPV5 SLC38A3 SLC9A6 HTT SLC5A2	9.90e-07	1157	69	16	GO:0006812
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	SLC46A3 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G MFSD8 SLC1A1 CNGA4 TRPV5 SLC9A6 HTT SLC5A2	1.04e-06	1017	69	15	GO:0098660
GeneOntologyBiologicalProcess	L-amino acid transport	SLC38A10 SLC6A17 SLC6A15 SLC1A1 SLC38A3 SLC16A10	1.64e-06	108	69	6	GO:0015807
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	SLC46A3 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G SLC1A1 CNGA4 TRPV5 SLC9A6 HTT SLC5A2	1.80e-06	922	69	14	GO:0098662
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	SLC46A3 SLC4A8 HCN4 SLC6A17 KCNJ11 SLC6A15 CACNA1H CACNA1G SLC1A1 CNGA4 TRPV5 SLC9A6 HTT SLC5A2	2.31e-06	942	69	14	GO:0098655
GeneOntologyBiologicalProcess	amino acid transmembrane transport	SLC38A10 SLC6A15 LRRC8D SLC1A1 SLC38A3 SLC16A10	3.04e-06	120	69	6	GO:0003333
GeneOntologyBiologicalProcess	amino acid transport	SLC38A10 SLC6A17 SLC6A15 LRRC8D SLC1A1 SLC38A3 SLC16A10	3.98e-06	195	69	7	GO:0006865
GeneOntologyBiologicalProcess	transport across blood-brain barrier	ABCC3 SLC4A8 SLC6A17 SLC1A1 SLC38A3	1.08e-05	87	69	5	GO:0150104
GeneOntologyBiologicalProcess	vascular transport	ABCC3 SLC4A8 SLC6A17 SLC1A1 SLC38A3	1.14e-05	88	69	5	GO:0010232
GeneOntologyBiologicalProcess	regulation of immune response	HMSD KIR2DL5B PIK3CA KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1 TLR8 EPG5	1.17e-05	1085	69	14	GO:0050776
GeneOntologyBiologicalProcess	sensory perception of smell	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1 CNGA4	2.38e-05	465	69	9	GO:0007608
GeneOntologyBiologicalProcess	intracellular chemical homeostasis	ABCG1 SLC4A8 PIK3CA KCNJ11 GCKR LRRC8D SLC1A1 SPPL2C TRPV5 SLC38A3 SLC9A6 HTT	2.70e-05	866	69	12	GO:0055082
GeneOntologyBiologicalProcess	neutral amino acid transport	SLC6A17 SLC6A15 SLC1A1 SLC38A3	4.86e-05	60	69	4	GO:0015804
GeneOntologyBiologicalProcess	organic anion transport	ABCC3 SLC38A10 SLC4A8 SLC6A17 SLC6A15 LRRC8D SLC1A1 SLC38A3 SLC16A10	5.27e-05	515	69	9	GO:0015711
GeneOntologyBiologicalProcess	cellular response to high density lipoprotein particle stimulus	ABCG4 ABCG1	6.59e-05	4	69	2	GO:0071403
GeneOntologyBiologicalProcess	carboxylic acid transport	ABCC3 SLC38A10 SLC6A17 SLC6A15 LRRC8D SLC1A1 SLC38A3 SLC16A10	6.60e-05	410	69	8	GO:0046942
GeneOntologyBiologicalProcess	organic acid transport	ABCC3 SLC38A10 SLC6A17 SLC6A15 LRRC8D SLC1A1 SLC38A3 SLC16A10	6.83e-05	412	69	8	GO:0015849
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1 CNGA4	8.36e-05	547	69	9	GO:0007606
GeneOntologyBiologicalProcess	cellular homeostasis	ABCG1 SLC4A8 PIK3CA KCNJ11 GCKR LRRC8D SLC1A1 SPPL2C TRPV5 SLC38A3 SLC9A6 HTT	9.00e-05	981	69	12	GO:0019725
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1	9.49e-05	432	69	8	GO:0050911
GeneOntologyBiologicalProcess	sodium ion import across plasma membrane	HCN4 SLC9A6 SLC5A2	9.89e-05	27	69	3	GO:0098719
GeneOntologyBiologicalProcess	glycoside transport	ABCC3 SLC5A2	1.10e-04	5	69	2	GO:1901656
GeneOntologyBiologicalProcess	membrane depolarization during SA node cell action potential	HCN4 CACNA1G	1.10e-04	5	69	2	GO:0086046
GeneOntologyBiologicalProcess	organic cation transport	SLC6A17 SLC6A15 SLC1A1 SLC38A3 SLC16A10	1.25e-04	145	69	5	GO:0015695
GeneOntologyBiologicalProcess	vascular process in circulatory system	ZDHHC21 ABCC3 SLC4A8 SLC6A17 CACNA1G SLC1A1 SLC38A3	1.50e-04	344	69	7	GO:0003018
GeneOntologyBiologicalProcess	circulatory system process	ZDHHC21 ABCC3 SLC4A8 HCN4 PIK3CA SLC6A17 CACNA1H CACNA1G SLC1A1 SLC38A3	1.54e-04	733	69	10	GO:0003013
GeneOntologyBiologicalProcess	monoatomic anion transmembrane transport	ABCC3 SLC4A8 MFSD8 LRRC8D SLC1A1	1.61e-04	153	69	5	GO:0098656
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1	2.10e-04	485	69	8	GO:0050907
GeneOntologyBiologicalProcess	carboxylic acid transmembrane transport	SLC38A10 SLC6A15 LRRC8D SLC1A1 SLC38A3	2.17e-04	163	69	5	GO:1905039
GeneOntologyBiologicalProcess	chemical homeostasis	ABCG4 ABCG1 SLC4A8 PIK3CA KCNJ11 GCKR LRRC8D SLC1A1 SPPL2C TRPV5 SLC38A3 SLC9A6 HTT	2.23e-04	1249	69	13	GO:0048878
GeneOntologyBiologicalProcess	membrane depolarization during action potential	HCN4 CACNA1H CACNA1G	2.36e-04	36	69	3	GO:0086010
GeneOntologyBiologicalProcess	organic acid transmembrane transport	SLC38A10 SLC6A15 LRRC8D SLC1A1 SLC38A3	2.42e-04	167	69	5	GO:1903825
GeneOntologyBiologicalProcess	cardiac muscle cell contraction	HCN4 PIK3CA CACNA1H CACNA1G	2.68e-04	93	69	4	GO:0086003
GeneOntologyBiologicalProcess	carbohydrate derivative transport	ABCC3 ABCG1 LRRC8D SLC5A2	3.02e-04	96	69	4	GO:1901264
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1	3.53e-04	524	69	8	GO:0009593
GeneOntologyBiologicalProcess	monoatomic anion transport	ABCC3 SLC4A8 MFSD8 LRRC8D SLC1A1	3.69e-04	183	69	5	GO:0006820
GeneOntologyBiologicalProcess	intracellular amino acid homeostasis	SLC1A1 SLC38A3	4.88e-04	10	69	2	GO:0080144
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell signaling	HCN4 CACNA1G	4.88e-04	10	69	2	GO:0086018
GeneOntologyBiologicalProcess	SA node cell action potential	HCN4 CACNA1G	4.88e-04	10	69	2	GO:0086015
GeneOntologyBiologicalProcess	L-leucine transport	SLC6A17 SLC6A15	4.88e-04	10	69	2	GO:0015820
GeneOntologyBiologicalProcess	calcium ion import across plasma membrane	CACNA1H CACNA1G TRPV5	5.56e-04	48	69	3	GO:0098703
GeneOntologyBiologicalProcess	calcium ion import into cytosol	CACNA1H CACNA1G TRPV5	5.56e-04	48	69	3	GO:1902656
GeneOntologyBiologicalProcess	SA node cell to atrial cardiac muscle cell communication	HCN4 CACNA1G	5.95e-04	11	69	2	GO:0086070
GeneOntologyBiologicalProcess	CAMKK-AMPK signaling cascade	KCNJ11 HTT	5.95e-04	11	69	2	GO:0061762
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8H2 ZDHHC21 OR7G1 OR51M1 OR51I2 OR52H1 GPR173 OR14J1 SMIM17 TSHB OR56A1 SLC1A1 HTT	6.44e-04	1395	69	13	GO:0007186
GeneOntologyBiologicalProcess	detection of stimulus	OR8H2 OR7G1 ABCA4 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1	6.51e-04	722	69	9	GO:0051606
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 SMIM17 OR56A1	7.05e-04	582	69	8	GO:0050906
GeneOntologyBiologicalProcess	determination of adult lifespan	KCNJ11 MFSD8 HTT	7.87e-04	54	69	3	GO:0008340
GeneOntologyBiologicalProcess	intracellular glucose homeostasis	ABCG1 PIK3CA KCNJ11 GCKR LRRC8D	8.17e-04	218	69	5	GO:0001678
GeneOntologyBiologicalProcess	import into cell	HCN4 PIK3CA KCNJ11 CACNA1H CACNA1G LRRC8D SLC1A1 TRPV5 SLC38A3 SLC9A6 SLC5A2	8.22e-04	1074	69	11	GO:0098657
GeneOntologyBiologicalProcess	sinoatrial node development	HCN4 CACNA1G	8.40e-04	13	69	2	GO:0003163
GeneOntologyBiologicalProcess	proline transport	SLC6A17 SLC6A15	8.40e-04	13	69	2	GO:0015824
GeneOntologyBiologicalProcess	aromatic amino acid transport	SLC38A3 SLC16A10	8.40e-04	13	69	2	GO:0015801
GeneOntologyBiologicalProcess	actin-mediated cell contraction	HCN4 PIK3CA CACNA1H CACNA1G	8.70e-04	127	69	4	GO:0070252
GeneOntologyBiologicalProcess	branched-chain amino acid transport	SLC6A17 SLC6A15	9.78e-04	14	69	2	GO:0015803
GeneOntologyBiologicalProcess	positive regulation of cholesterol biosynthetic process	ABCG4 ABCG1	1.13e-03	15	69	2	GO:0045542
GeneOntologyBiologicalProcess	positive regulation of sterol biosynthetic process	ABCG4 ABCG1	1.13e-03	15	69	2	GO:0106120
GeneOntologyBiologicalProcess	positive regulation of regulated secretory pathway	SLC4A8 CACNA1H CACNA1G	1.41e-03	66	69	3	GO:1903307
GeneOntologyBiologicalProcess	alanine transport	SLC6A17 SLC38A3	1.63e-03	18	69	2	GO:0032328
GeneOntologyBiologicalProcess	actin filament-based movement	HCN4 PIK3CA CACNA1H CACNA1G	1.73e-03	153	69	4	GO:0030048
GeneOntologyBiologicalProcess	positive regulation of calcium ion-dependent exocytosis	CACNA1H CACNA1G	2.02e-03	20	69	2	GO:0045956
GeneOntologyBiologicalProcess	positive regulation of cholesterol metabolic process	ABCG4 ABCG1	2.02e-03	20	69	2	GO:0090205
GeneOntologyCellularComponent	cytoplasmic vesicle membrane	ABCG4 ABCA4 SLC4A8 SLC6A17 CD109 KIR3DL3 MFSD8 KIR2DL3 KIR2DS4 KIR3DL1 SLC1A1 SPPL2C CNGA4 SLC9A6 TLR8 HTT	4.06e-06	1307	69	16	GO:0030659
GeneOntologyCellularComponent	monoatomic ion channel complex	HCN4 KCNJ11 CACNA1H CACNA1G MFSD8 TMEM262 LRRC8D CNGA4 TRPV5	4.09e-06	378	69	9	GO:0034702
GeneOntologyCellularComponent	vesicle membrane	ABCG4 ABCA4 SLC4A8 SLC6A17 CD109 KIR3DL3 MFSD8 KIR2DL3 KIR2DS4 KIR3DL1 SLC1A1 SPPL2C CNGA4 SLC9A6 TLR8 HTT	4.84e-06	1325	69	16	GO:0012506
GeneOntologyCellularComponent	cation channel complex	HCN4 KCNJ11 CACNA1H CACNA1G TMEM262 CNGA4 TRPV5	1.24e-05	235	69	7	GO:0034703
GeneOntologyCellularComponent	transmembrane transporter complex	HCN4 KCNJ11 CACNA1H CACNA1G MFSD8 TMEM262 LRRC8D CNGA4 TRPV5	5.35e-05	523	69	9	GO:1902495
GeneOntologyCellularComponent	early endosome membrane	KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1 SLC1A1 SLC9A6	7.14e-05	212	69	6	GO:0031901
GeneOntologyCellularComponent	transporter complex	HCN4 KCNJ11 CACNA1H CACNA1G MFSD8 TMEM262 LRRC8D CNGA4 TRPV5	7.88e-05	550	69	9	GO:1990351
GeneOntologyCellularComponent	basolateral plasma membrane	ABCC3 SLC4A8 HCN4 CLDN7 SLC38A3 CLDN8 SLC16A10	8.83e-05	320	69	7	GO:0016323
GeneOntologyCellularComponent	calcium channel complex	CACNA1H CACNA1G TMEM262 TRPV5	9.97e-05	73	69	4	GO:0034704
GeneOntologyCellularComponent	endosome membrane	ABCG4 KIR3DL3 MFSD8 KIR2DL3 KIR2DS4 KIR3DL1 SLC1A1 SLC9A6 TLR8	1.56e-04	602	69	9	GO:0010008
GeneOntologyCellularComponent	basal plasma membrane	ABCC3 SLC4A8 HCN4 CLDN7 SLC38A3 CLDN8 SLC16A10	1.65e-04	354	69	7	GO:0009925
GeneOntologyCellularComponent	basal part of cell	ABCC3 SLC4A8 HCN4 CLDN7 SLC38A3 CLDN8 SLC16A10	2.46e-04	378	69	7	GO:0045178
GeneOntologyCellularComponent	endosome	ABCG4 ABCG1 KCNJ11 KIR3DL3 MFSD8 KIR2DL3 KIR2DS4 KIR3DL1 SLC1A1 SLC9A6 TLR8 HTT	3.98e-04	1167	69	12	GO:0005768
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1H CACNA1G TMEM262	4.72e-04	46	69	3	GO:0005891
GeneOntologyCellularComponent	early endosome	KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1 SLC1A1 SLC9A6 HTT	1.03e-03	481	69	7	GO:0005769
GeneOntologyCellularComponent	voltage-gated sodium channel complex	CACNA1H CACNA1G	1.41e-03	17	69	2	GO:0001518
GeneOntologyCellularComponent	neuronal cell body	SERPINI1 SLC4A8 HCN4 KCNJ11 CACNA1H CACNA1G SLC1A1 CNGA4 HTT	1.64e-03	835	69	9	GO:0043025
GeneOntologyCellularComponent	endoplasmic reticulum membrane	TMX1 YIPF5 ABCG1 OR51M1 SMIM17 CYP2S1 SYVN1 LRRC8D SPPL2C SLC9A6 TLR8	3.23e-03	1293	69	11	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	TMX1 YIPF5 ABCG1 OR51M1 SMIM17 CYP2S1 SYVN1 LRRC8D SPPL2C SLC9A6 TLR8	3.35e-03	1299	69	11	GO:0098827
GeneOntologyCellularComponent	cell body	SERPINI1 SLC4A8 HCN4 KCNJ11 CACNA1H CACNA1G SLC1A1 CNGA4 HTT	3.37e-03	929	69	9	GO:0044297
GeneOntologyCellularComponent	membrane protein complex	TRAV3 HCN4 PIK3CA KCNJ11 CACNA1H CACNA1G MFSD8 TMEM262 SYVN1 LRRC8D CNGA4 TRPV5	3.40e-03	1498	69	12	GO:0098796
GeneOntologyCellularComponent	apicolateral plasma membrane	CLDN7 CLDN8	3.84e-03	28	69	2	GO:0016327
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	TMX1 YIPF5 ABCG1 OR51M1 SMIM17 CYP2S1 SYVN1 LRRC8D SPPL2C SLC9A6 TLR8	3.94e-03	1327	69	11	GO:0042175
GeneOntologyCellularComponent	sodium channel complex	CACNA1H CACNA1G	4.12e-03	29	69	2	GO:0034706
GeneOntologyCellularComponent	axon terminus	SLC4A8 HCN4 SLC1A1 SLC9A6	5.14e-03	210	69	4	GO:0043679
GeneOntologyCellularComponent	perikaryon	SERPINI1 CACNA1H SLC1A1 CNGA4	6.34e-03	223	69	4	GO:0043204
GeneOntologyCellularComponent	somatodendritic compartment	SERPINI1 SLC4A8 HCN4 KCNJ11 CACNA1H CACNA1G SLC1A1 CNGA4 SLC9A6 HTT	6.79e-03	1228	69	10	GO:0036477
GeneOntologyCellularComponent	neuron projection terminus	SLC4A8 HCN4 SLC1A1 SLC9A6	7.39e-03	233	69	4	GO:0044306
MousePheno	astrocytosis	CACNA1G MFSD8 SLC9A6 HTT EPG5	2.36e-05	103	47	5	MP:0003354
MousePheno	increased astrocyte number	CACNA1G MFSD8 SLC9A6 HTT EPG5	2.84e-05	107	47	5	MP:0012065
MousePheno	microgliosis	MFSD8 SLC9A6 HTT EPG5	2.91e-05	53	47	4	MP:0008918
MousePheno	abnormal astrocyte number	CACNA1G MFSD8 SLC9A6 HTT EPG5	3.54e-05	112	47	5	MP:0012064
MousePheno	sebaceous gland hyperplasia	ZDHHC21 CD109	1.10e-04	5	47	2	MP:0009794
MousePheno	abnormal hair follicle infundibulum morphology	ZDHHC21 CD109	1.10e-04	5	47	2	MP:0010682
MousePheno	abnormal astrocyte morphology	CACNA1G MFSD8 SLC9A6 HTT EPG5	1.66e-04	155	47	5	MP:0002182
MousePheno	abnormal microglial cell morphology	MFSD8 SLC9A6 HTT EPG5	2.04e-04	87	47	4	MP:0000136
MousePheno	dilated hair follicle	ZDHHC21 CD109	2.30e-04	7	47	2	MP:0010699
MousePheno	gliosis	CACNA1G MFSD8 SLC9A6 HTT EPG5	2.62e-04	171	47	5	MP:0002183
MousePheno	increased urine creatinine level	SLC5A2 SLC16A10	3.06e-04	8	47	2	MP:0011470
Domain	ig	SEMA4D KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.03e-09	190	65	10	PF00047
Domain	Immunoglobulin	SEMA4D KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.03e-09	190	65	10	IPR013151
Domain	IG	SEMA4D KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.80e-06	421	65	10	SM00409
Domain	Ig_sub	SEMA4D KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.80e-06	421	65	10	IPR003599
Domain	ABCG1	ABCG4 ABCG1	1.19e-05	2	65	2	IPR020064
Domain	ABC_transporter_CS	ABCG4 ABCC3 ABCG1 ABCA4	1.35e-05	42	65	4	IPR017871
Domain	ABC_TRANSPORTER_2	ABCG4 ABCC3 ABCG1 ABCA4	2.32e-05	48	65	4	PS50893
Domain	ABC_tran	ABCG4 ABCC3 ABCG1 ABCA4	2.32e-05	48	65	4	PF00005
Domain	ABC_TRANSPORTER_1	ABCG4 ABCC3 ABCG1 ABCA4	2.52e-05	49	65	4	PS00211
Domain	ABC_transporter-like	ABCG4 ABCC3 ABCG1 ABCA4	2.73e-05	50	65	4	IPR003439
Domain	SIS	GCKR GFPT2	3.57e-05	3	65	2	PS51464
Domain	SIS	GCKR GFPT2	3.57e-05	3	65	2	IPR001347
Domain	VDCC_T_a1	CACNA1H CACNA1G	3.57e-05	3	65	2	IPR005445
Domain	Ion_trans_dom	HCN4 CACNA1H CACNA1G CNGA4 TRPV5	4.78e-05	114	65	5	IPR005821
Domain	Ion_trans	HCN4 CACNA1H CACNA1G CNGA4 TRPV5	4.78e-05	114	65	5	PF00520
Domain	IG_LIKE	SEMA4D KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	4.82e-05	491	65	9	PS50835
Domain	Ig-like_dom	SEMA4D KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	5.81e-05	503	65	9	IPR007110
Domain	Na/ntran_symport_orphan	SLC6A17 SLC6A15	1.18e-04	5	65	2	IPR002438
Domain	ABC_2_trans	ABCG4 ABCG1	1.18e-04	5	65	2	IPR013525
Domain	ABC2_membrane	ABCG4 ABCG1	1.18e-04	5	65	2	PF01061
Domain	Ig-like_fold	SEMA4D KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.53e-04	706	65	10	IPR013783
Domain	Olfact_rcpt	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 OR56A1	4.22e-04	393	65	7	IPR000725
Domain	VDCCAlpha1	CACNA1H CACNA1G	5.27e-04	10	65	2	IPR002077
Domain	cNMP-bd_CS	HCN4 CNGA4	1.39e-03	16	65	2	IPR018488
Domain	Aa_trans	SLC38A10 SLC38A3	1.57e-03	17	65	2	PF01490
Domain	AA_transpt_TM	SLC38A10 SLC38A3	1.57e-03	17	65	2	IPR013057
Domain	AAA+_ATPase	ABCG4 ABCC3 ABCG1 ABCA4	1.59e-03	144	65	4	IPR003593
Domain	AAA	ABCG4 ABCC3 ABCG1 ABCA4	1.59e-03	144	65	4	SM00382
Domain	NA_NEUROTRAN_SYMP_2	SLC6A17 SLC6A15	1.76e-03	18	65	2	PS00754
Domain	NA_NEUROTRAN_SYMP_3	SLC6A17 SLC6A15	1.96e-03	19	65	2	PS50267
Domain	SNF	SLC6A17 SLC6A15	1.96e-03	19	65	2	PF00209
Domain	Na/ntran_symport	SLC6A17 SLC6A15	1.96e-03	19	65	2	IPR000175
Domain	NA_NEUROTRAN_SYMP_1	SLC6A17 SLC6A15	1.96e-03	19	65	2	PS00610
Domain	-	SEMA4D KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR3DL1 KIR3DS1	2.05e-03	663	65	8	2.60.40.10
Domain	GPCR_Rhodpsn_7TM	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 GPR173 OR14J1 OR56A1	2.19e-03	670	65	8	IPR017452
Domain	7tm_1	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 GPR173 OR14J1 OR56A1	2.33e-03	677	65	8	PF00001
Domain	MFS	SLC46A3 MFSD8 SLC16A10	2.45e-03	77	65	3	IPR011701
Domain	MFS_1	SLC46A3 MFSD8 SLC16A10	2.45e-03	77	65	3	PF07690
Domain	G_PROTEIN_RECEP_F1_1	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 GPR173 OR14J1 OR56A1	2.51e-03	685	65	8	PS00237
Domain	Claudin_CS	CLDN7 CLDN8	2.63e-03	22	65	2	IPR017974
Domain	CLAUDIN	CLDN7 CLDN8	2.63e-03	22	65	2	PS01346
Domain	G_PROTEIN_RECEP_F1_2	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 GPR173 OR14J1 OR56A1	2.65e-03	691	65	8	PS50262
Domain	GPCR_Rhodpsn	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 GPR173 OR14J1 OR56A1	2.67e-03	692	65	8	IPR000276
Domain	Claudin	CLDN7 CLDN8	4.25e-03	28	65	2	IPR006187
Domain	CNMP_BINDING_1	HCN4 CNGA4	5.53e-03	32	65	2	PS00888
Domain	CNMP_BINDING_2	HCN4 CNGA4	5.53e-03	32	65	2	PS00889
Domain	cNMP	HCN4 CNGA4	6.23e-03	34	65	2	SM00100
Domain	cNMP_binding	HCN4 CNGA4	6.23e-03	34	65	2	PF00027
Domain	MFS	SLC46A3 MFSD8 SLC16A10	6.33e-03	108	65	3	PS50850
Domain	cNMP-bd_dom	HCN4 CNGA4	6.59e-03	35	65	2	IPR000595
Domain	CNMP_BINDING_3	HCN4 CNGA4	6.59e-03	35	65	2	PS50042
Domain	Serpin_dom	HMSD SERPINI1	6.96e-03	36	65	2	IPR023796
Domain	SERPIN	HMSD SERPINI1	7.34e-03	37	65	2	PS00284
Domain	Serpin	HMSD SERPINI1	7.73e-03	38	65	2	PF00079
Domain	cNMP-bd-like	HCN4 CNGA4	7.73e-03	38	65	2	IPR018490
Domain	Serpin_fam	HMSD SERPINI1	8.13e-03	39	65	2	IPR000215
Domain	PMP22_Claudin	CLDN7 CLDN8	8.54e-03	40	65	2	PF00822
Pathway	REACTOME_DAP12_INTERACTIONS	PIK3CA KIR2DS2 KIR2DL5A KIR2DS4 KIR2DS5 KIR3DS1	2.76e-08	46	57	6	M27151
Pathway	KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION	KIR3DL3 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	5.95e-08	88	57	7	M16004
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCG4 ABCC3 ABCG1 ABCA4 SLC4A8 KCNJ11 SLC6A15 LRRC8D SLC1A1 TRPV5 SLC38A3 SLC9A6 SLC5A2 SLC16A10	3.68e-07	681	57	14	MM14985
Pathway	REACTOME_TRANSPORT_OF_SMALL_MOLECULES	ABCG4 ABCC3 ABCG1 ABCA4 SLC4A8 KCNJ11 SLC6A15 LRRC8D SLC1A1 TRPV5 SLC38A3 SLC9A6 SLC5A2 SLC16A10	9.36e-07	736	57	14	M27287
Pathway	KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY	PIK3CA KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	1.24e-06	137	57	7	M5669
Pathway	REACTOME_DAP12_INTERACTIONS	PIK3CA KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1	2.46e-06	54	57	5	MM14871
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC4A8 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC16A10	4.65e-06	108	57	6	M823
Pathway	REACTOME_TRANSPORT_OF_INORGANIC_CATIONS_ANIONS_AND_AMINO_ACIDS_OLIGOPEPTIDES	SLC4A8 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC16A10	4.90e-06	109	57	6	MM15074
Pathway	KEGG_GRAFT_VERSUS_HOST_DISEASE	KIR2DL5A KIR2DL2 KIR2DL3 KIR3DL1	2.18e-05	41	57	4	M13519
Pathway	KEGG_ABC_TRANSPORTERS	ABCG4 ABCC3 ABCG1 ABCA4	2.89e-05	44	57	4	M11911
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC4A8 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC5A2 SLC16A10	4.61e-05	238	57	7	MM15076
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCG4 ABCC3 ABCG1 ABCA4 KCNJ11	4.84e-05	99	57	5	MM14986
Pathway	REACTOME_ABC_FAMILY_PROTEINS_MEDIATED_TRANSPORT	ABCG4 ABCC3 ABCG1 ABCA4 KCNJ11	5.85e-05	103	57	5	M758
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC4A8 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC5A2 SLC16A10	6.14e-05	249	57	7	M5988
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 OR56A1 CNGA4	1.58e-04	389	57	8	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8H2 OR7G1 OR51M1 OR51I2 OR52H1 OR14J1 OR56A1 CNGA4	2.54e-04	417	57	8	M4072
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC6A15 SLC38A3 SLC16A10	2.86e-04	32	57	3	MM14957
Pathway	REACTOME_AMINO_ACID_TRANSPORT_ACROSS_THE_PLASMA_MEMBRANE	SLC6A15 SLC38A3 SLC16A10	3.14e-04	33	57	3	M188
Pathway	REACTOME_SLC_TRANSPORTER_DISORDERS	GCKR SLC1A1 SLC9A6 SLC5A2	6.80e-04	99	57	4	M27474
Pathway	REACTOME_DISORDERS_OF_TRANSMEMBRANE_TRANSPORTERS	KCNJ11 GCKR SLC1A1 SLC9A6 SLC5A2	7.28e-04	177	57	5	M27476
Pathway	KEGG_TYPE_II_DIABETES_MELLITUS	PIK3CA KCNJ11 CACNA1G	8.96e-04	47	57	3	M19708
Pathway	REACTOME_SENSORY_PERCEPTION	OR8H2 OR7G1 ABCA4 OR51M1 OR51I2 OR52H1 OR14J1 OR56A1 CNGA4	9.45e-04	636	57	9	M41834
Pubmed	[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	9.18e-24	17	69	10	19218127
Pubmed	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	9.18e-24	17	69	10	20878400
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	9.18e-24	17	69	10	20650299
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	9.18e-24	17	69	10	19450876
Pubmed	Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	9.18e-24	17	69	10	19761533
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	8.68e-23	20	69	10	20193031
Pubmed	Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.	KIR2DL5B KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.96e-22	13	69	9	19120281
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.03e-22	22	69	10	20492596
Pubmed	Frequencies of killer immunoglobulin-like receptor genotypes influence susceptibility to spontaneous abortion.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	5.49e-22	14	69	9	19875891
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the Chinese Han population.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	5.49e-22	14	69	9	15896204
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Caucasian population of southern Brazil.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.37e-21	15	69	9	20082646
Pubmed	Disparate distribution of activating and inhibitory killer cell immunoglobulin-like receptor genes in patients with systemic lupus erythematosus.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.37e-21	15	69	9	19926642
Pubmed	[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.37e-21	15	69	9	20356536
Pubmed	Inhibitory KIR and specific HLA-C gene combinations confer susceptibility to or protection against chronic hepatitis B.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.37e-21	15	69	9	20643584
Pubmed	Killer cell immunoglobulin-like receptor genotype and killer cell immunoglobulin-like receptor-human leukocyte antigen C ligand compatibility affect the severity of hepatitis C virus recurrence after liver transplantation.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.37e-21	15	69	9	19326408
Pubmed	Killer cell immunoglobulin-like receptor gene-cluster 3DS1-2DL5-2DS1-2DS5 predisposes susceptibility to Vogt-Koyanagi-Harada syndrome in Japanese individuals.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	19897003
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Java, Kalimantan, Timor and Irian Jaya.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	19000141
Pubmed	Diversity of killer cell immunoglobulin-like receptor genes in Indonesian populations of Sumatra, Sulawesi and Moluccas Islands.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	20670355
Pubmed	Activating killer cell immunoglobulin-like receptor genes' association with recurrent miscarriage.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	19527230
Pubmed	Polymorphisms of KIR gene and HLA-C alleles: possible association with susceptibility to HLA-B27-positive patients with ankylosing spondylitis.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	20652381
Pubmed	Asian population frequencies and haplotype distribution of killer cell immunoglobulin-like receptor (KIR) genes among Chinese, Malay, and Indian in Singapore.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	18668235
Pubmed	Influence of activating and inhibitory killer immunoglobulin-like receptors on predisposition to recurrent miscarriages.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	19279038
Pubmed	No association of KIR genes with Behcet's disease.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	17868255
Pubmed	A study of the killer cell immunoglobulin-like receptor gene KIR2DS1 in a Caucasoid Brazilian population with psoriasis vulgaris.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	18643961
Pubmed	Distribution of killer cell immunoglobulin-like receptor (KIR) genotypes in patients with familial Mediterranean fever.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	19309280
Pubmed	Report from the killer immunoglobulin-like receptor (KIR) anthropology component of the 15th International Histocompatibility Workshop: worldwide variation in the KIR loci and further evidence for the co-evolution of KIR and HLA.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	20331834
Pubmed	[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	3.13e-21	16	69	9	16403292
Pubmed	HLA-DQA1*0505 sharing and killer immunoglobulin-like receptors in sub fertile couples: report from the 15th International Histocompatibility Workshop.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.13e-21	16	69	9	20210919
Pubmed	The role of killer immunoglobulin-like receptor haplotypes on the outcome of unrelated donor haematopoietic SCT for thalassaemia.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	6.64e-21	17	69	9	20173792
Pubmed	Role of killer cell immunoglobulin-like receptor gene content and human leukocyte antigen-C group in susceptibility to human T-lymphotropic virus 1-associated myelopathy/tropical spastic paraparesis in Peru.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	6.64e-21	17	69	9	20483367
Pubmed	[Effects of killer immunoglobulin-like receptor and human leukocyte antigen class I ligand on the prognosis of related donor hematopoietic stem cell transplantation].	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	6.64e-21	17	69	9	19968064
Pubmed	KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	6.64e-21	17	69	9	19169284
Pubmed	Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.33e-20	18	69	9	19630074
Pubmed	Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.33e-20	18	69	9	20519398
Pubmed	Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	1.33e-20	18	69	9	20200544
Pubmed	Combination of KIR 2DL2 and HLA-C1 (Asn 80) confers susceptibility to type 1 diabetes in Latvians.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.33e-20	18	69	9	19046302
Pubmed	Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.33e-20	18	69	9	19846535
Pubmed	Association of killer cell immunoglobulin-like receptors and human leukocyte antigen-C genotypes in South Brazilian with type 1 diabetes.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.33e-20	18	69	9	20580654
Pubmed	Distribution of killer cell immunoglobulin-like receptor genes in the mestizo population from Venezuela.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.33e-20	18	69	9	20210918
Pubmed	KIR and HLA gene combinations in Vogt-Koyanagi-Harada disease.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.52e-20	19	69	9	18571006
Pubmed	Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.52e-20	19	69	9	18778326
Pubmed	Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.52e-20	19	69	9	20600442
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.52e-20	19	69	9	18848853
Pubmed	Natural killer cells and immune surveillance.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.59e-20	11	69	8	18830515
Pubmed	[Genotype analysis of killer cell immunoglobulin-like receptors in Graves' disease patients].	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.59e-20	11	69	8	19664392
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	4.57e-20	20	69	9	20426625
Pubmed	Association of killer cell immunoglobulin-like receptor 2DL5 with systemic lupus erythematosus and accompanying infections.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	7.75e-20	12	69	8	20371502
Pubmed	[Polymorphism of killer cell immunoglobulin-like receptor gene and its correlation with leukemia].	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	7.75e-20	12	69	8	17490516
Pubmed	Distribution of killer cell immunoglobulin-like receptors (KIR) and their HLA-C ligands in two Iranian populations.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	7.75e-20	12	69	8	19936734
Pubmed	Activating killer cell immunoglobulin-like receptors 3DS1 and 2DS1 protect against developing the severe form of recurrent respiratory papillomatosis.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	7.98e-20	21	69	9	19861144
Pubmed	Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	8.43e-20	35	69	10	19683555
Pubmed	[Study on the polymorphism of killer cell immunoglobulin like receptor (KIR) gene with systemic lupus erythematosus of North population in China].	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.01e-19	13	69	8	18687225
Pubmed	Multiple sclerosis associates with LILRA3 deletion in Spanish patients.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	4.69e-19	14	69	8	19421224
Pubmed	[Genotype and haplotype analysis of killer cell immunoglobulin-like receptors in ankylosing spondylitis].	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR3DL1 KIR3DS1	4.69e-19	14	69	8	19489269
Pubmed	Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	4.69e-19	14	69	8	18945962
Pubmed	KIR haplotype content at the allele level in 77 Northern Irish families.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR3DL1 KIR3DS1	7.06e-19	8	69	7	17200871
Pubmed	Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.00e-18	15	69	8	19850842
Pubmed	Natural killer-cell receptor polymorphisms and posttransplantation non-Hodgkin lymphoma.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.00e-18	15	69	8	20207982
Pubmed	Killer immunoglobulin-like receptors (KIR2DL2 and/or KIR2DS2) in presence of their ligand (HLA-C1 group) protect against chronic myeloid leukaemia.	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.00e-18	15	69	8	19493232
Pubmed	KIR genes polymorphism in Argentinean Caucasoid and Amerindian populations.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	1.00e-18	15	69	8	17498266
Pubmed	Immunogenetic characteristics of patients with autoimmune gastritis.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.68e-18	29	69	9	20082482
Pubmed	Alternatively spliced forms of human killer inhibitory receptors.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.17e-18	9	69	7	8662091
Pubmed	Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.	KIR3DL3 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.78e-18	17	69	8	19032228
Pubmed	The beneficial impact of missing KIR ligands and absence of donor KIR2DS3 gene on outcome following unrelated hematopoietic SCT for myeloid leukemia in the Chinese population.	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DS1	3.78e-18	17	69	8	20173784
Pubmed	Different patterns of evolution in the centromeric and telomeric regions of group A and B haplotypes of the human killer cell Ig-like receptor locus.	KIR2DL5B KIR3DL3 KIR2DL2 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.06e-17	10	69	7	21206914
Pubmed	Association of killer cell immunoglobulin-like receptors with primary Sjogren's syndrome.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	6.95e-17	12	69	7	19181658
Pubmed	[Relationship between CMV reactivation and KIR haplotype/HLA-Cw genotype in patients after unrelated-donor hematopoietic stem cell transplantation.].	KIR2DS2 KIR2DL5A KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	6.95e-17	12	69	7	20137308
Pubmed	KIR and HLA genotypes are associated with disease progression and survival following autologous hematopoietic stem cell transplantation for high-risk neuroblastoma.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	1.50e-16	13	69	7	19934297
Pubmed	Molecular clones of the p58 NK cell receptor reveal immunoglobulin-related molecules with diversity in both the extra- and intracellular domains.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	4.08e-15	9	69	6	7749980
Pubmed	Activation of a subset of human NK cells upon contact with Plasmodium falciparum-infected erythrocytes.	KIR2DS2 KIR2DL2 KIR2DS4 KIR2DS5 KIR3DL1	5.55e-13	7	69	5	14607943
Pubmed	A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia.	KIR3DL3 KIR2DL2 KIR2DL3 KIR2DS4 KIR3DL1	1.48e-12	8	69	5	15730517
Pubmed	NullHap--a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5	1.48e-12	8	69	5	18681957
Pubmed	Assessment of killer cell immunoglobulinlike receptor expression and corresponding HLA class I phenotypes demonstrates heterogenous KIR expression independent of anticipated HLA class I ligands.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS5 KIR3DL1	6.63e-12	10	69	5	12559621
Pubmed	Activating KIR genes are associated with ankylosing spondylitis in Asian populations.	KIR2DL5A KIR2DS5 KIR3DL1 KIR3DS1	1.42e-11	4	69	4	18638658
Pubmed	High-throughput genotyping of KIR2DL2/L3, KIR3DL1/S1, and their HLA class I ligands using real-time PCR.	KIR2DL2 KIR2DL3 KIR3DL1 KIR3DS1	1.42e-11	4	69	4	19522772
Pubmed	Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.	KIR2DL5B KIR2DL5A KIR2DS5 KIR3DS1	1.42e-11	4	69	4	22652695
Pubmed	Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.	KIR2DL5B KIR2DL5A KIR2DL2 KIR2DS5	1.42e-11	4	69	4	18498296
Pubmed	KIR gene in ethnic and Mestizo populations from Mexico.	KIR2DL5A KIR2DL2 KIR2DS5 KIR3DS1	7.08e-11	5	69	4	16698429
Pubmed	Associations of killer cell immunoglobulin-like receptor genes with complications of rheumatoid arthritis.	KIR2DS2 KIR2DL2 KIR2DL3 KIR3DS1	2.12e-10	6	69	4	17882223
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphism in lymphoproliferative diseases of granular lymphocytes in a Japanese population.	KIR2DS2 KIR2DL5A KIR3DL1 KIR3DS1	2.12e-10	6	69	4	20528243
Pubmed	Identification of the mouse killer immunoglobulin-like receptor-like (Kirl) gene family mapping to chromosome X.	KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1	4.94e-10	7	69	4	12618911
Pubmed	Expression of a killer cell receptor-like gene in plastic regions of the central nervous system.	KIR3DL3 KIR2DL3 KIR2DS4 KIR3DL1	4.94e-10	7	69	4	15748957
Pubmed	Identification of seventeen novel KIR variants: fourteen of them from two non-Caucasian donors.	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4	4.94e-10	7	69	4	11169255
Pubmed	Polymorphisms of killer cell immunoglobulin-like receptor gene: possible association with susceptibility to or clearance of hepatitis B virus infection in Chinese Han population.	KIR3DL3 KIR2DS2 KIR2DL5A KIR3DS1	1.77e-09	9	69	4	18074414
Pubmed	Combination of KIR and HLA gene variants augments the risk of developing birdshot chorioretinopathy in HLA-A*29-positive individuals.	KIR2DS2 KIR2DS4 KIR3DL1 KIR3DS1	1.77e-09	9	69	4	18340360
Pubmed	Killer immunoglobulin receptor genes and their HLA-C ligand are associated with Type 1 diabetes in an Eastern Indian population.	KIR2DL2 KIR2DL3 KIR2DS4	7.47e-09	3	69	3	26031759
Pubmed	NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.	KIR2DS2 KIR2DS4 KIR3DS1	7.47e-09	3	69	3	23325834
Pubmed	Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer.	KIR2DS2 KIR2DL2 KIR2DS4	7.47e-09	3	69	3	38387251
Pubmed	Killer cell immunoglobulin-like receptor (KIR) genes in the Basque population: association study of KIR gene contents with type 1 diabetes mellitus.	KIR2DL2 KIR2DS5 KIR3DS1	7.47e-09	3	69	3	16698433
Pubmed	Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients.	KIR2DS2 KIR2DL2 KIR2DL3	7.47e-09	3	69	3	30696053
Pubmed	Killer immunoglobulin-like receptor genotype may distinguish immunodeficient HIV-infected patients resistant to immune restoration diseases associated with herpes virus infections.	KIR2DL5A KIR2DS5 KIR3DS1	7.47e-09	3	69	3	17592337
Pubmed	[Correlation of killer immunoglobulin-like receptor gene diversity with nasopharyngeal carcinoma in Chinese southern Han population].	KIR2DL5B KIR2DL3 KIR2DS5	7.47e-09	3	69	3	21729574
Pubmed	Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population.	KIR2DL2 KIR2DL3 KIR2DS4	7.47e-09	3	69	3	32422377
Pubmed	KIR3DL1/S1 genotypes and KIR2DS4 allelic variants in the AB KIR genotypes are associated with Plasmodium-positive individuals in malaria infection.	KIR2DS4 KIR3DL1 KIR3DS1	7.47e-09	3	69	3	19859704
Pubmed	Associations of killer cell immunoglobulin- like receptor genes with rheumatoid arthritis.	KIR2DS2 KIR2DL2 KIR2DL3	7.47e-09	3	69	3	22960345
Pubmed	Imputation of KIR Types from SNP Variation Data.	KIR2DS2 KIR2DL2 KIR2DL3	7.47e-09	3	69	3	26430804
Pubmed	Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes.	KIR2DS2 KIR2DL2 KIR2DL3	7.47e-09	3	69	3	18292496
Pubmed	Killer Ig-like receptor (KIR) genotype and HLA ligand combinations in ulcerative colitis susceptibility.	KIR2DS2 KIR2DL2 KIR2DL3	2.99e-08	4	69	3	16929347
Pubmed	Genetic interactions of KIR and G1M immunoglobulin allotypes differ in obese from non-obese individuals with type 2 diabetes.	KIR2DL3 KIR2DS4 KIR3DL1	2.99e-08	4	69	3	18632158
Pubmed	Killer immunoglobulin-like receptor gene repertoire influences viral load of primary human cytomegalovirus infection in renal transplant patients.	KIR2DL5A KIR2DS5 KIR3DS1	2.99e-08	4	69	3	25253288
Interaction	KIR2DL2 interactions	KIR2DS2 KIR2DL2 KIR3DL1 KIR3DS1	6.07e-08	13	63	4	int:KIR2DL2
Interaction	KIR2DS2 interactions	KIR2DS2 KIR2DL2 KIR2DS5 KIR3DL1	5.30e-06	37	63	4	int:KIR2DS2
Interaction	KIR3DL1 interactions	KIR2DS2 KIR2DL2 KIR3DL1	8.14e-06	13	63	3	int:KIR3DL1
Interaction	TAFA2 interactions	CD109 KIR3DL3 KIR2DL5A KIR3DL1	1.40e-05	47	63	4	int:TAFA2
Interaction	KIR2DS5 interactions	KIR3DL3 KIR2DS2 KIR2DS5	1.58e-05	16	63	3	int:KIR2DS5
Interaction	KIR2DS3 interactions	KIR2DS2 KIR2DL2 KIR2DS5	3.20e-05	20	63	3	int:KIR2DS3
Interaction	SLC22A9 interactions	ZDHHC21 MFSD8 SYVN1 SLC9A6 SLC16A10	3.67e-05	120	63	5	int:SLC22A9
Interaction	KIR3DP1 interactions	KIR2DS2 KIR2DS5	5.75e-05	4	63	2	int:KIR3DP1
Interaction	UPK2 interactions	KIR3DL3 CLDN7 KIR2DL3 SLC1A1 SLC16A10	8.19e-05	142	63	5	int:UPK2
Interaction	KIR3DL3 interactions	KIR3DL3 NINJ2 KIR2DS5	1.11e-04	30	63	3	int:KIR3DL3
Interaction	SGK1 interactions	PIK3CA ASPG SYVN1 HTT	1.15e-04	80	63	4	int:SGK1
Cytoband	19q13.4	KIR2DS2 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	3.37e-11	79	69	7	19q13.4
Cytoband	11p15.4	OR51M1 OR51I2 OR52H1 OR56A1 CNGA4	1.34e-05	200	69	5	11p15.4
Cytoband	Ensembl 112 genes in cytogenetic band chr11p15	OR51M1 OR51I2 OR52H1 KCNJ11 OR56A1 CNGA4	2.08e-04	564	69	6	chr11p15
Cytoband	17q22	ABCC3 CACNA1G	2.02e-03	44	69	2	17q22
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL5B KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 KIR3DS1	2.63e-21	18	59	10	620
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	SEMA4D CD109 KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1 TLR8	5.01e-08	394	59	11	471
GeneFamily	Solute carriers	SLC38A10 SLC46A3 SLC4A8 SLC6A17 SLC6A15 SLC1A1 SLC38A3 SLC9A6 SLC5A2 SLC16A10	5.35e-07	395	59	10	752
GeneFamily	Blood group antigens\|CD molecules\|ATP binding cassette subfamily G	ABCG4 ABCG1	1.04e-04	5	59	2	811
GeneFamily	Cyclic nucleotide gated channels	HCN4 CNGA4	4.63e-04	10	59	2	250
GeneFamily	Claudins	CLDN7 CLDN8	2.53e-03	23	59	2	488
GeneFamily	Calcium voltage-gated channel subunits	CACNA1H CACNA1G	3.24e-03	26	59	2	253
GeneFamily	Olfactory receptors, family 51	OR51M1 OR51I2	9.07e-03	44	59	2	164
Coexpression	KAZMIN_PBMC_P_FALCIPARUM_RTSS_AS01_AGE_UNKNOWN_CORRELATED_WITH_PROTECTION_56DY_NEGATIVE	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS5 KIR3DL1	3.65e-11	49	66	7	M40909
Coexpression	GSE26495_PD1HIGH_VS_PD1LOW_CD8_TCELL_DN	KIR3DL3 KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	2.64e-08	190	66	8	M4662
Coexpression	GSE45739_UNSTIM_VS_ACD3_ACD28_STIM_NRAS_KO_CD4_TCELL_DN	KIR2DS2 KIR2DL5A KIR2DL2 KIR2DL3 KIR2DS5 KIR3DS1	1.10e-05	199	66	6	M9885
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-Tregs\|GI_small-bowel / Manually curated celltypes from each tissue	ZCCHC12 CD109 NINJ2 SLC5A2 SLC16A10	3.13e-06	157	64	5	c44bd530e396b08f16f284e185dcb830843959ea
ToppCell	droplet-Heart-4Chambers-21m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SERPINI1 SLC4A8 SLC6A17 CACNA1H CACNA1G	6.97e-06	185	64	5	30df02fbe2828e3c4f3e5c4cda855e74fb31be39
Computational	Neighborhood of IL2RB	KIR3DL3 KIR2DS2 KIR2DS4 KIR3DL1	1.10e-05	46	33	4	GNF2_IL2RB
Computational	Genes in the cancer module 186.	ABCC3 ABCG1 SLC38A3	2.90e-05	20	33	3	MODULE_186
Computational	Genes in the cancer module 71.	ABCC3 ABCG1 SLC9A6	3.90e-05	22	33	3	MODULE_71
Drug	Aa1	HCN4 KIR3DL3 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	5.36e-09	83	68	7	CID009549188
Drug	D-Au	KIR3DL3 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5 KIR3DL1	1.14e-07	77	68	6	CID000277822
Drug	AC1L2VU3	CACNA1H CACNA1G TSHB	5.50e-06	12	68	3	CID000129572
Drug	1xa5	KIR3DL3 KIR2DL2 KIR2DL3 KIR2DS4 SLC16A10	8.68e-06	93	68	5	CID000157684
Drug	pentasulfane	CACNA1H CACNA1G TSHB	1.39e-05	16	68	3	CID000448216
Drug	asparagine	ASPG SLC6A15 SLC1A1 SLC38A3	1.91e-05	53	68	4	CID000000236
Drug	1,3-dioxoisoindoline-5-carboxamide	CACNA1H CACNA1G	2.63e-05	3	68	2	CID010679219
Drug	AC1L1AQK	KIR3DL3 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5	2.87e-05	119	68	5	CID000001105
Drug	Ab-9	KIR2DL2 KIR2DL3 KIR3DL1	3.26e-05	21	68	3	CID006540280
Drug	1c88	KIR3DL3 KIR2DL2 KIR2DL3 KIR2DS4 KIR2DS5	3.78e-05	126	68	5	CID000444766
Drug	ponasterone A	KIR2DL2 KIR2DL3 SLC1A1 SLC9A6	5.75e-05	70	68	4	CID000115127
Drug	alfacalcidol	ABCC3 TSHB TRPV5	6.31e-05	26	68	3	ctd:C008088
Disease	level of killer cell immunoglobulin-like receptor 2DS2 in blood serum	KIR3DL3 KIR2DL3	1.34e-05	3	63	2	OBA_2042107
Disease	alpha 1-antitrypsin deficiency (implicated_via_orthology)	SERPINI1 SYVN1	9.36e-05	7	63	2	DOID:13372 (implicated_via_orthology)
Disease	prediabetes syndrome (biomarker_via_orthology)	SLC4A8 KCNJ11	2.92e-04	12	63	2	DOID:11716 (biomarker_via_orthology)
Disease	Colorectal Neoplasms	ABCC3 ABCG1 ABCA4 PIK3CA CD109	3.17e-04	277	63	5	C0009404
Disease	glycochenodeoxycholate glucuronide (1) measurement	ABCC3 CACNA1G	3.45e-04	13	63	2	EFO_0800474
Disease	Malformations of Cortical Development	PIK3CA SLC1A1	4.02e-04	14	63	2	C1955869
Disease	Cortical Dysplasia	PIK3CA SLC1A1	4.02e-04	14	63	2	C0431380
Disease	killer cell immunoglobulin-like receptor 2DS2 measurement	KIR3DL3 KIR2DL3	4.63e-04	15	63	2	EFO_0801746
Disease	leptin measurement, type 2 diabetes mellitus	KCNJ11 GCKR	5.28e-04	16	63	2	EFO_0005000, MONDO_0005148
Disease	triacylglycerol 50:5 measurement	YIPF5 GCKR	5.28e-04	16	63	2	EFO_0010412
Disease	malaria (is_implicated_in)	KIR3DL1 KIR3DS1	1.20e-03	24	63	2	DOID:12365 (is_implicated_in)
Disease	diacylglycerol 34:2 measurement	YIPF5 GCKR	1.30e-03	25	63	2	EFO_0010353
Disease	macular telangiectasia type 2	CD109 GCKR	1.41e-03	26	63	2	EFO_1002009
Disease	hepatitis C (is_implicated_in)	KIR3DL1 KIR3DS1	1.64e-03	28	63	2	DOID:1883 (is_implicated_in)
Disease	tuberculosis (is_implicated_in)	KIR3DL1 KIR3DS1	1.64e-03	28	63	2	DOID:399 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
FMSEMPFGTLSVQML	EPG5	706	Q9HCE0
MLFLMFAALMPTVLT	ABCG4	431	Q9H172
GDEFSFLLSMQMMLL	ABCA4	831	P78363
FLLSMQMMLLDAAVY	ABCA4	836	P78363
SMLFLMFAALMPTVL	ABCG1	461	P45844
MLLAALMIVSMVSYG	HERVK_113	76	P61574
MSLMVVSMACVGFFL	KIR2DS2	1	P43631
MFLSSVGFSVVMMSI	MFSD8	46	Q8NHS3
LVAGLMFLCSMMQSL	ABCC3	351	O15438
LQGFLVMLAAMAMAA	ABCC3	1021	O15438
MSLMVISMACVGFFL	KIR2DL5A	1	Q8N109
MGLTLSEEIQMALFM	OR8H2	16	Q8N162
MSLMVVSMACVGFFL	KIR2DL2	1	P43627
MSLMVIIMACVGFFL	KIR2DS4	1	P43632
MSLMVVSMVCVGFFL	KIR2DL3	1	P43628
TDTMAFAASMLSFML	ASPG	116	Q86U10
NMLMTVIYLLFAGTM	CYP2S1	291	Q96SQ9
MSLMVVSMACVGFFL	KIR2DL5B	1	Q8NHK3
MSLMVVSMACVGLFL	KIR3DL1	1	P43629
GLMINAIMLGCIFMK	KCNJ11	156	Q14654
MVNLTSMSGFLLMGF	OR14J1	1	Q9UGF5
FFSMMESGILLAMSF	OR51I2	106	Q9H344
FMESSVLLMMSFDRL	OR51M1	121	Q9H341
MSLMVVSMACVGFFL	KIR3DL3	1	Q8N743
ATIFMGRQMSAILSM	KIZ	156	Q2M2Z5
MLSMIVGATCYAMFI	HCN4	496	Q9Y3Q4
NLFINLFSMMLGSGM	PIK3CA	996	P42336
MSLMVISMACVAFFL	KIR2DS5	1	Q14953
GRMAFLMSVSFNQLM	GCKR	111	Q14397
LLSMFMSTMDALVQS	OR7G1	146	Q8NGA0
SGMALMEVNLLSGFM	CD109	1311	Q6YHK3
MAALGLMLTCMYTGK	HTT	2916	P42858
SQFISLVMFGLMMSE	GFPT2	481	O94808
LVMFGLMMSEDRISL	GFPT2	486	O94808
TMDNVATFCMLLMLF	CACNA1G	861	O43497
TLGFMLMLAVLMAAT	GPR173	186	Q9NS66
MSISSALAMVFMGAK	HMSD	1	A8MTL9
SMLVIMLNCVTLGMF	CACNA1H	106	O95180
MMASIQSFSAMALLF	SLC38A10	146	Q9HBR0
FAMGMAQALLTALMI	SLC1A1	316	P43005
LAVVMLMVAIFAGTM	LRRC8D	31	Q7L1W4
LQMFIMNSFLPMESC	OR56A1	106	Q8NGH5
ILFSPLSIALAMGMM	SERPINI1	46	Q99574
PMFFFLSMLAMTDLI	OR52H1	66	Q8NGJ2
SMLDVALFMSNAMRL	NINJ2	36	Q9NZG7
MNIMLAFTISLLGML	MT-ND4L	6	P03901
LCLEGMMLSLFIMAT	MT-ND4L	31	P03901
MFRTAVMMAASLALT	SYVN1	1	Q86TM6
VMFFLMLVNLGLGSM	SLC6A15	461	Q9H2J7
MLGFLLMTMSLSFII	SLC38A3	476	Q99624
MMMFAGLRGAMAFAL	SLC9A6	451	Q92581
MLLMVVSMACVGLFL	KIR3DS1	1	Q14943
MTAFASTTLMMFLAR	SLC46A3	341	Q7Z3Q1
AVGLLVTFMAMVLMQ	SPPL2C	481	Q8IUH8
CVLFLFLVLTGMPMM	SMIM17	101	P0DL12
TGLMIFVLMGCSVFM	SLC4A8	881	Q2Y0W8
LMALAVMFGTAMAFA	SEMA4D	11	Q92854
GFLAMFVATMGMKCT	CLDN7	91	O95471
AASVMSFLAFMMAIL	CLDN8	86	P56748
FLLAVMGFATIMGSM	CNGA4	251	Q8IV77
NTMIFMILGASVVMA	TMEM240	6	Q5SV17
MENMFLQSSMLTCIF	TLR8	1	Q9NR97
LMLAVMLAALMSSLA	SLC5A2	381	P31639
MASAPISMLAMLFTL	TRAV3	1	A0A0B4J244
LGMFCLLNLMSMTGV	YIPF5	161	Q969M3
MVMSFRVSDLQMLLG	PIAS4	11	Q8N2W9
LMSMLFGLTCGQAMS	TSHB	6	P01222
FFPKGMMLTTAALML	TMEM262	11	E9PQX1
MMLTTAALMLFFLHL	TMEM262	16	E9PQX1
ELAIMRLAAFMGITM	ZDHHC21	176	Q8IVQ6
MFFLMLINLGLGSMI	SLC6A17	461	Q9H1V8
SVLMSSMSALFQLSM	TMX1	146	Q9H3N1
LMGGAMQLTFRKMAF	UHRF1BP1	351	Q6BDS2
CILIMQILGMAFSMT	TSPAN9	211	O75954
IMASMADRNMKLFSG	ZCCHC12	36	Q6PEW1
ATLLMLNLFIAMMGD	TRPV5	566	Q9NQA5
LQVLSFFFIGLMSMM	SLC16A10	361	Q8TF71
LMSMMIPLCSIFGAL	SLC16A10	371	Q8TF71