Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
Domain-

PTK2B FRMPD4 ACBD4

8.56e-04497131.20.80.10
DomainFERM/acyl-CoA-bd_prot_3-hlx

PTK2B FRMPD4 ACBD4

9.08e-0450713IPR014352
Domain-

MST1R MXRA5 EPHA6 ICAM5 TMIGD2 RELB TNXB SEMA4G

3.59e-036637182.60.40.10
DomainTyrKc

MST1R PTK2B EPHA6

4.59e-0388713SM00219
DomainTyr_kinase_cat_dom

MST1R PTK2B EPHA6

4.59e-0388713IPR020635
DomainIPT

MST1R RELB

4.70e-0327712SM00429
DomainIg-like_fold

MST1R MXRA5 EPHA6 ICAM5 TMIGD2 RELB TNXB SEMA4G

5.23e-03706718IPR013783
DomainUbiquitin-rel_dom

PTK2B FRMPD4 RGL2 PLEKHG5

5.30e-03184714IPR029071
DomainPROTEIN_KINASE_TYR

MST1R PTK2B EPHA6

6.01e-0397713PS00109
DomainTyr_kinase_AS

MST1R PTK2B EPHA6

6.01e-0397713IPR008266
DomainTIG

MST1R RELB

6.17e-0331712PF01833
DomainSema

MST1R SEMA4G

6.17e-0331712SM00630
DomainSemap_dom

MST1R SEMA4G

6.17e-0331712IPR001627
DomainSema

MST1R SEMA4G

6.17e-0331712PF01403
DomainSEMA

MST1R SEMA4G

6.17e-0331712PS51004
DomainPSI

MST1R SEMA4G

6.57e-0332712PF01437
DomainIPT

MST1R RELB

6.57e-0332712IPR002909
DomainPlexin_repeat

MST1R SEMA4G

6.57e-0332712IPR002165
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

MST1R VOPP1 SH3PXD2B PSME4 PLEKHO2 KANK3 ADGRB2 RELB SRCAP ARID1A RGL2 PLEKHG5 ARAP1

6.39e-071105751335748872
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

SH3PXD2B CAD BRD8 ICAM5 KDM2B DBN1 SRCAP ARID1A EMSY

2.84e-0654975938280479
Pubmed

Drebrin E regulates neuroblast proliferation and chain migration in the adult brain.

ICAM5 DBN1

4.59e-06275228833685
Pubmed

Exon sharing of a novel human zinc-finger gene, ZIM2, and paternally expressed gene 3 (PEG3).

PEG3 ZIM2

4.59e-06275210708526
Pubmed

Drebrin Isoforms Critically Regulate NMDAR- and mGluR-Dependent LTD Induction.

ICAM5 DBN1

4.59e-06275230349460
Pubmed

Effect of BSN-MST1 locus on inflammatory bowel disease and multiple sclerosis susceptibility.

MST1R BSN

1.37e-05375219657358
Pubmed

Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension.

CYP11B1 KCNK9

4.57e-05575230580687
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

MXRA5 COQ8A PTPRN2 KDM2B BSN ARID1A CSPP1 AKR7A2

7.03e-0563875831182584
Pubmed

A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.

TNXB EMSY

9.57e-05775223886662
Pubmed

Semaphorin 4B interacts with the post-synaptic density protein PSD-95/SAP90 and is recruited to synapses through a C-terminal PDZ-binding motif.

BSN SEMA4G

1.27e-04875215978582
Pubmed

Drebrin regulates cytoskeleton dynamics in migrating neurons through interaction with CXCR4.

DBN1 GFAP

1.64e-04975233414275
Pubmed

DNA damage-induced activation of ATM promotes β-TRCP-mediated ARID1A ubiquitination and destruction in gastric cancer cells.

FBXW5 ARID1A

2.04e-041075231210753
Pubmed

Genomic imprinting in Dicer1-hypomorphic mice.

RTL1 PEG3

2.49e-041175216575173
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

BRD8 SALL3 ARID1A EMSY

2.87e-0414675423892456
Pubmed

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.

C2CD4A ARAP1

2.99e-041275221873549
Pubmed

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.

WSCD1 BRD8 PTPRN2 KCNK9

3.10e-0414975425231870
Pubmed

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase.

MST1R BSN

3.52e-041375210508511
Pubmed

PRC1 and PRC2 are not required for targeting of H2A.Z to developmental genes in embryonic stem cells.

BRD8 KDM2B EMSY

3.82e-046575322496869
Pubmed

O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry.

BSN EMSY

4.11e-041475216452088
Pubmed

SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion.

PTK2B GFAP

4.11e-041475212771190
Pubmed

Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.

GFAP SEMA4G

4.73e-041575221122816
Pubmed

CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development.

RP1 GFAP

4.73e-041575219680541
Pubmed

H19 acts as a trans regulator of the imprinted gene network controlling growth in mice.

RTL1 PEG3

4.73e-041575219762426
Pubmed

An Oct4-centered protein interaction network in embryonic stem cells.

BRD8 SALL3 ARID1A EMSY

4.78e-0416775420362541
Pubmed

Tissue distribution and subcellular localization of the family of Kidney Ankyrin Repeat Domain (KANK) proteins.

KANK3 GFAP

5.40e-041675233253712
Pubmed

A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.

MST1R BSN

5.40e-041675225082827
Pubmed

Fbxw7α- and GSK3-mediated degradation of p100 is a pro-survival mechanism in multiple myeloma.

FBXW5 RELB

5.40e-041675222388891
Pubmed

Identification of a polymorphic, neuron-specific chromatin remodeling complex.

ARID1A GFAP

6.11e-041775212368262
Pubmed

mSin3A/histone deacetylase 2- and PRMT5-containing Brg1 complex is involved in transcriptional repression of the Myc target gene cad.

CAD ARID1A

6.87e-041875214559996
Pubmed

M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP.

BRD8 FBXW5

6.87e-041875215070733
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

CCDC8 CAD BRD8 TTBK1 PTPRN2 CFAP70

7.16e-0449675631343991
Pubmed

The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes.

BRD8 SRCAP

7.66e-041975215647280
Pubmed

Endothelial Arid1a deletion disrupts the balance among angiogenesis, neurogenesis and gliogenesis in the developing brain.

ARID1A GFAP

7.66e-041975236916004
Pubmed

The protein tyrosine kinase family of the human genome.

MST1R PTK2B EPHA6

7.82e-048375311114734
Pubmed

PTPN23 binds the dynein adaptor BICD1 and is required for endocytic sorting of neurotrophin receptors.

MICALL2 NCKIPSD

8.50e-042075232079660
Pubmed

The ULK1-FBXW5-SEC23B nexus controls autophagy.

FBXW5 KDM2B

8.50e-042075230596474
Pubmed

Requiem protein links RelB/p52 and the Brm-type SWI/SNF complex in a noncanonical NF-kappaB pathway.

RELB ARID1A

9.38e-042175220460684
Pubmed

Plexin-B2 controls the development of cerebellar granule cells.

GFAP SEMA4G

9.38e-042175217409257
Pubmed

Nineteen additional unpredicted transcripts from human chromosome 21.

BRWD1-AS2 PRDM15

9.38e-042175212036297
Pubmed

Human transcription factor protein interaction networks.

CCDC8 CAD BRD8 KDM2B PABPC1L RELB DBN1 SRCAP ARID1A EMSY

9.70e-041429751035140242
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

PTK2B CAD ICAM5 NCKIPSD ZC3HC1 DBN1 BSN ARID1A PLEKHG5 GFAP

9.81e-041431751037142655
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PSME4 COQ8A KDM2B BSN PLEKHG5 ARAP1

9.98e-0452975614621295
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

SH3PXD2B CAD PTPRN2 ICAM5 ADGRB2 DBN1 BSN EMSY

1.10e-0396375828671696
Pubmed

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.

VOPP1 TICAM2 PLEKHG5

1.12e-039475312761501
Pubmed

Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

BRD8 SRCAP

1.13e-032375214966270
Pubmed

The m6A reader YTHDF2 is a negative regulator for dendrite development and maintenance of retinal ganglion cells.

BSN GFAP

1.23e-032475235179492
Pubmed

The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.

SH3PXD2B MICALL2 BSN PPP1R13L

1.29e-0321875433378226
Pubmed

Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

FRMPD4 PTPRN2 SRCAP

1.50e-031047539205841
Pubmed

Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation.

RELB ARID1A

1.67e-032875230037996
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

CAD KDM2B BSN SRCAP ARID1A EMSY

1.71e-0358875638580884
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

SHROOM1 TRAFD1 FBXW5 NCKIPSD PABPC1L RELB PPP1R13L KLHL20

1.77e-03103875826673895
Pubmed

RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex.

CAD ARID1A

1.79e-032975236800290
Pubmed

Identification of FBXO25-interacting proteins using an integrated proteomics approach.

CAD DBN1 GFAP

1.85e-0311275320473970
Pubmed

Necessity and Sufficiency of Ldb1 in the Generation, Differentiation and Maintenance of Non-photoreceptor Cell Types During Retinal Development.

SALL3 GFAP

1.92e-033075230127719
Pubmed

The QTL within the H2 Complex Involved in the Control of Tuberculosis Infection in Mice Is the Classical Class II H2-Ab1 Gene.

KANK3 RGL2

2.05e-033175226618355
Pubmed

KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.

KDM2B GFAP

2.05e-033175237838801
InteractionS100B interactions

CCDC8 SALL3 FBXW5 KDM2B ZC3HC1 HEMK1 PPP1R13L GFAP

2.19e-07179718int:S100B
Cytoband19q13.32

CCDC8 RELB PPP1R13L

2.50e-047475319q13.32
Cytoband10q24.31

PDZD7 SEMA4G

4.42e-041975210q24.31
GeneFamilyZinc fingers|Zinc fingers PARP-type|Poly(ADP-ribose) polymerases

ZC3HC1 BSN

8.00e-041551226
ToppCellHippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_1|Hippocampus / BrainAtlas - Mouse McCarroll V32

PTK2B ICAM5 C2CD4A PLEKHG5 TNXB

4.51e-06144755e2a2f260f5ebaaef46248d199c407a15ce9d024a
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 MXRA5 FRMPD4 DBN1 PPP1R13L

1.01e-051707550cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

FAT2 MXRA5 FRMPD4 DBN1 PPP1R13L

1.01e-051707552d880223d01bde4bf777bd6f50b7d2768489075f
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B PTPRN2 ICAM5 ADGRB2 BSN

1.60e-05187755e04a84989d624378141042768383b9c846901f2d
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B PTPRN2 ICAM5 ADGRB2 BSN

1.60e-0518775524cc03c748e15f7ef0e6509ca5a6ca583fb9c573
ToppCellfacs-Brain_Non-Myeloid-Hippocampus-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B PTPRN2 ICAM5 ADGRB2 BSN

1.60e-051877552f153b203fe79f206319603cf94d3a03ab49a05d
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B PTPRN2 RTL1 ICAM5 BSN

1.87e-05193755461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B PTPRN2 RTL1 ICAM5 BSN

1.87e-051937550dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PTK2B PTPRN2 RTL1 ICAM5 BSN

1.96e-05195755ffbab350e67d9c4b66c0ab84550daec8b8139a27
Diseaseage at menarche

WSCD1 CPA5 PTPRN2 RTL1 ZC3HC1 BSN ARID1A KCNK9

1.21e-04594748EFO_0004703
Diseaseparental longevity

PIK3AP1 MST1R TRAFD1 ADGRB2 ZC3HC1 BSN KCNK9

2.42e-04494747EFO_0007796
DiseaseAlzheimer disease, gastroesophageal reflux disease

MICALL2 PTPRN2 RELB PPP1R13L CR1L

2.75e-04228745EFO_0003948, MONDO_0004975
Diseaseserum gamma-glutamyl transferase measurement

PIK3AP1 WSCD1 SH3PXD2B CYP11B1 KDM2B RP1 ARID1A EMSY SEMA4G

4.60e-04914749EFO_0004532
DiseaseBurkitt Leukemia

SALL3 ARID1A

6.38e-0415742C4721444
DiseaseAfrican Burkitt's lymphoma

SALL3 ARID1A

6.38e-0415742C0343640
Diseasegranulysin measurement

CYP11B1 FBXW5

6.38e-0415742EFO_0008144
DiseaseNasopharyngeal carcinoma

MST1R ARID1A

1.39e-0322742C2931822
DiseaseIntrahepatic Cholangiocarcinoma

PEG3 ARID1A

1.65e-0324742C0345905
DiseaseExtrahepatic Cholangiocarcinoma

PEG3 ARID1A

1.65e-0324742C3805278
DiseaseCholangiocarcinoma

PEG3 ARID1A

1.94e-0326742C0206698
DiseaseAdenoid Cystic Carcinoma

ZIM2 SRCAP ARID1A

2.06e-03100743C0010606

Protein segments in the cluster

PeptideGeneStartEntry
PEPGERSRTMPRTVP

ADGRB2

1436

O60241
RRTGPRRPVREMTLP

BRWD1-AS2

101

P59051
RALAMSRPPPPRVAS

AKR7A2

26

O43488
QVIPDMPRPPETFLR

ACBD4

121

Q8NC06
PPRRLPTVMVRSPID

BRD8

176

Q9H0E9
MSLERPPRVPPRAAS

PIK3AP1

771

Q6ZUJ8
IMDRPPRSPKEPLIS

ATP2A1

816

O14983
RAMPSRRVARPPAAP

RELB

16

Q01201
RQRMATRPPDRPEGP

PTPRN2

671

Q92932
MVIHIPEEPRPSRPR

KCNK9

271

Q9NPC2
APAPVQPPMIRRDIT

ARID1A

1626

O14497
RARATVAPLPMTPVP

M1AP

486

Q8TC57
VRAQLAPRPPMAPRS

MAGED4

381

Q96JG8
GLSLRMVPPVFIPRP

HEMK1

121

Q9Y5R4
LTRVPMIAPRVPLGP

BSN

2241

Q9UPA5
RGPARPSLPVDMRVP

CPA5

71

Q8WXQ8
EMSPQRRVPRPRPRS

CCDC194

191

A0A1B0GVG4
RVLGLPSRMEPPAPL

MICALL2

506

Q8IY33
PRTMRVLQAPRPRPR

FBXW5

541

Q969U6
LMPSRPPSPRERLVA

FAT2

4251

Q9NYQ8
TFQRPDRVELMPLPP

ICAM5

116

Q9UMF0
EPMELVVRVPGPSPR

PDZD7

941

Q9H5P4
MIPPERPRIAFQTPL

CSPP1

476

Q1MSJ5
RRMAPTPIPTRSPSD

DBN1

326

Q16643
RLSLARMPPPLPTRV

GFAP

36

P14136
RMPPPLPTRVDFSLA

GFAP

41

P14136
SMVRPPVVPRRPPAH

PABPC1L

446

Q4VXU2
PRSRMPPRDLSLPVV

PEG3

186

Q9GZU2
MPRAFLVRSRRPQPP

OVOL3

1

O00110
PLMQGPRTRPRKPIR

KLHL20

301

Q9Y2M5
IQMERHVIRPPPISP

KDM2B

1036

Q8NHM5
LARRVKEMIPPRPPL

CFAP70

486

Q5T0N1
KEMIPPRPPLTRRTG

CFAP70

491

Q5T0N1
IIPPAPRKVEMRRDP

FRMPD4

71

Q14CM0
IMLDVDTRRPVPPLT

B3GAT2

21

Q9NPZ5
MAPPVRLERPFPSRR

CR1L

1

Q2VPA4
LPDPTRIPIPMARLV

CYP4A22

481

Q5TCH4
VPRTVLPFEAMPRRP

CYP11B1

31

P15538
IPVMLRHRLVPPPEE

COQ8A

591

Q8NI60
TRLMVRSAPPTQRPP

C19orf73

66

Q9NVV2
VPFPSPQRPRILVQM

DENND4B

361

O75064
MQPLSPRAPVRNPRV

KANK3

116

Q6NY19
GRRLVPLMPRLVPQT

EMSY

96

Q7Z589
LRRPEGPAEPMVVVP

PTK2B

16

Q14289
PRVRRRVQQMVTPPP

CCDC8

76

Q9H0W5
IRSQVALMQRPPPRP

SALL3

226

Q9BXA9
PRGAPRQRPIPLSMI

PPP1R13L

361

Q8WUF5
IPEFCIPPRLMPRLA

C2CD4A

46

Q8NCU7
APGMPRPPRSLVVFR

RP1

146

P56715
SLPPRIPAGRPVMIV

EPHA6

736

Q9UF33
SLRPAPAMRVARPQP

RTL1

1106

A6NKG5
VPMPPPRSSRRLRAG

RGL2

81

O15211
QIEALDPPMRLPRRP

TRAFD1

171

O14545
DPPMRLPRRPLRAFE

TRAFD1

176

O14545
APPVREMTLRDLPSP

LRRC27

186

Q9C0I9
GDVVIPRPRVQPMRV

PRDM15

106

P57071
LEEAPLVRMRSPPDP

SHROOM1

391

Q2M3G4
IPMRPLNNPLPRERT

TICAM2

171

Q86XR7
PQSPRPRRPTMSTVV

KCTD14

21

Q9BQ13
ARAPMPTPTLVRPLL

SRCAP

1361

Q6ZRS2
TPPPPVKRRDREALM

NCKIPSD

181

Q9NZQ3
EPAIRPRSSQRVPPM

TDGF1

56

P13385
RPTPRPVPMKRHIFR

ARAP1

76

Q96P48
VEPPPRRPMSQKSEI

XIRP2

2976

A4UGR9
RPERLPLVPESPRRM

ZC3HC1

311

Q86WB0
MAELVPRAPESPRVP

PLEKHG5

836

O94827
IRRRMYPPPLIEEPA

VOPP1

81

Q96AW1
ATRSRIPRPIGLRMP

TTBK1

1151

Q5TCY1
RPGHPVSMVRVSPRP

TMIGD2

251

Q96BF3
LMARPVVPTRGRPLL

SEMA4G

406

Q9NTN9
PPPRRDMTIPRGLNL

SH3PXD2B

346

A1X283
PRPLLQRELMVPGTR

TNXB

3701

P22105
TRTPPRTSQRRMPPR

nan

116

A8MUU9
RMPPRTSQTRTPPRA

nan

126

A8MUU9
LMRPELVIPPVLERT

PSME4

426

Q14997
PPSLRMPPTVRAFVA

CAD

2106

P27708
PRSRMPPRDLSLPVV

ZIM2

61

Q9NZV7
VSEAQPRETPRPLMP

PLEKHO2

191

Q8TD55
DMLQSPLTRPRPGPR

WSCD1

86

Q658N2
SPMPGNVRRPRPLSE

MST1R

1381

Q04912
QRSELPIRPVPPAAM

THEGL

361

P0DJG4
TRRPQIPTSPAPVMR

MXRA5

1746

Q9NR99