Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in AV node cell action potential	CACNA1C CACNA1G	4.17e-05	3	75	2	GO:0086056
GeneOntologyMolecularFunction	histone H3K9 trimethyltransferase activity	SETDB1 PRDM2	1.38e-04	5	75	2	GO:0140949
GeneOntologyMolecularFunction	voltage-gated calcium channel activity involved in cardiac muscle cell action potential	CACNA1C CACNA1G	1.38e-04	5	75	2	GO:0086007
GeneOntologyMolecularFunction	ion channel regulator activity	NRXN3 ANK2 RSC1A1 WNK4 WNK3	3.61e-04	162	75	5	GO:0099106
GeneOntologyMolecularFunction	channel regulator activity	NRXN3 ANK2 RSC1A1 WNK4 WNK3	5.00e-04	174	75	5	GO:0016247
GeneOntologyMolecularFunction	transporter regulator activity	NRXN3 ANK2 RSC1A1 WNK4 WNK3	5.41e-04	177	75	5	GO:0141108
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	SETDB1 KMT2D PRDM2	6.03e-04	44	75	3	GO:0140938
GeneOntologyMolecularFunction	potassium channel inhibitor activity	WNK4 WNK3	7.49e-04	11	75	2	GO:0019870
GeneOntologyMolecularFunction	ion channel inhibitor activity	RSC1A1 WNK4 WNK3	7.80e-04	48	75	3	GO:0008200
GeneOntologyMolecularFunction	channel inhibitor activity	RSC1A1 WNK4 WNK3	8.79e-04	50	75	3	GO:0016248
GeneOntologyMolecularFunction	transporter inhibitor activity	RSC1A1 WNK4 WNK3	9.31e-04	51	75	3	GO:0141110
GeneOntologyMolecularFunction	histone H3K9 methyltransferase activity	SETDB1 PRDM2	1.06e-03	13	75	2	GO:0046974
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1G	1.23e-03	14	75	2	GO:0008331
GeneOntologyMolecularFunction	potassium channel regulator activity	ANK2 WNK4 WNK3	1.29e-03	57	75	3	GO:0015459
GeneOntologyMolecularFunction	phosphatidylinositol-3,5-bisphosphate phosphatase activity	PIKFYVE MTMR4	1.61e-03	16	75	2	GO:0106018
GeneOntologyMolecularFunction	histone modifying activity	SETDB1 KMT2D KDM4A PRDM2 MSL2	1.71e-03	229	75	5	GO:0140993
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	SETDB1 KMT2D PRDM2	2.14e-03	68	75	3	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	SETDB1 KMT2D PRDM2	2.23e-03	69	75	3	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	SETDB1 KMT2D PRDM2	2.42e-03	71	75	3	GO:0042054
GeneOntologyMolecularFunction	protein serine kinase activity	PIKFYVE PIM3 MAP3K14 RIPK4 WNK4 WNK3	2.43e-03	363	75	6	GO:0106310
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	ARHGAP42 RALGAPA1 PLEKHG4 PLEKHG3 IQSEC1 HERC2 RGS16	2.92e-03	507	75	7	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	ARHGAP42 RALGAPA1 PLEKHG4 PLEKHG3 IQSEC1 HERC2 RGS16	2.92e-03	507	75	7	GO:0030695
GeneOntologyBiologicalProcess	AV node cell to bundle of His cell signaling	CACNA1C ANK2 CACNA1G	1.07e-05	12	77	3	GO:0086027
GeneOntologyBiologicalProcess	AV node cell action potential	CACNA1C ANK2 CACNA1G	1.07e-05	12	77	3	GO:0086016
GeneOntologyBiologicalProcess	AV node cell to bundle of His cell communication	CACNA1C ANK2 CACNA1G	2.20e-05	15	77	3	GO:0086067
GeneOntologyBiologicalProcess	membrane depolarization during cardiac muscle cell action potential	CACNA1C ANK2 CACNA1G	8.40e-05	23	77	3	GO:0086012
GeneOntologyBiologicalProcess	negative regulation of receptor recycling	AP1AR OPTN	1.37e-04	5	77	2	GO:0001920
GeneOntologyBiologicalProcess	membrane depolarization during SA node cell action potential	ANK2 CACNA1G	1.37e-04	5	77	2	GO:0086046
GeneOntologyBiologicalProcess	negative regulation of pancreatic juice secretion	WNK4 WNK3	1.37e-04	5	77	2	GO:0090188
GeneOntologyBiologicalProcess	membrane depolarization during AV node cell action potential	CACNA1C CACNA1G	2.04e-04	6	77	2	GO:0086045
GeneOntologyBiologicalProcess	negative regulation of protein localization to plasma membrane	RSC1A1 WNK4 WNK3	2.09e-04	31	77	3	GO:1903077
GeneOntologyBiologicalProcess	negative regulation of protein localization to cell periphery	RSC1A1 WNK4 WNK3	2.52e-04	33	77	3	GO:1904376
GeneOntologyBiologicalProcess	cell-cell signaling involved in cardiac conduction	CACNA1C ANK2 CACNA1G	2.75e-04	34	77	3	GO:0086019
GeneOntologyBiologicalProcess	positive regulation of potassium ion import across plasma membrane	WNK4 WNK3	2.85e-04	7	77	2	GO:1903288
GeneOntologyBiologicalProcess	membrane depolarization during action potential	CACNA1C ANK2 CACNA1G	3.27e-04	36	77	3	GO:0086010
GeneOntologyBiologicalProcess	negative regulation of protein localization	PIM3 KLF7 AKAP1 RSC1A1 WNK4 WNK3	4.51e-04	263	77	6	GO:1903828
GeneOntologyBiologicalProcess	negative regulation of protein localization to membrane	RSC1A1 WNK4 WNK3	4.81e-04	41	77	3	GO:1905476
GeneOntologyBiologicalProcess	regulation of heart rate by cardiac conduction	CACNA1C ANK2 CACNA1G	4.81e-04	41	77	3	GO:0086091
GeneOntologyBiologicalProcess	regulation of potassium ion import	WNK4 WNK3	4.87e-04	9	77	2	GO:1903286
GeneOntologyBiologicalProcess	regulation of pancreatic juice secretion	WNK4 WNK3	4.87e-04	9	77	2	GO:0090186
GeneOntologyBiologicalProcess	positive regulation of potassium ion transmembrane transport	ANK2 WNK4 WNK3	5.17e-04	42	77	3	GO:1901381
Domain	TUDOR	TDRD5 SETDB1 KDM4A AKAP1	2.47e-06	23	79	4	PS50304
Domain	TUDOR	TDRD5 SETDB1 KDM4A AKAP1	4.83e-06	27	79	4	SM00333
Domain	Tudor	TDRD5 SETDB1 KDM4A AKAP1	7.47e-06	30	79	4	IPR002999
Domain	Znf_FYVE_PHD	PIKFYVE KMT2D MTMR4 ZFYVE16 KDM4A UHRF2	3.72e-05	147	79	6	IPR011011
Domain	FYVE	PIKFYVE MTMR4 ZFYVE16	2.46e-04	29	79	3	PF01363
Domain	FYVE	PIKFYVE MTMR4 ZFYVE16	2.46e-04	29	79	3	SM00064
Domain	Kinase_OSR1/WNK_CCT	WNK4 WNK3	2.62e-04	6	79	2	IPR024678
Domain	OSR1_C	WNK4 WNK3	2.62e-04	6	79	2	PF12202
Domain	Znf_FYVE-rel	PIKFYVE MTMR4 ZFYVE16	3.97e-04	34	79	3	IPR017455
Domain	Znf_FYVE	PIKFYVE MTMR4 ZFYVE16	5.52e-04	38	79	3	IPR000306
Domain	ZF_FYVE	PIKFYVE MTMR4 ZFYVE16	6.43e-04	40	79	3	PS50178
Domain	SET	SETDB1 KMT2D PRDM2	6.92e-04	41	79	3	PF00856
Domain	ZF_PHD_2	KMT2D ASXL3 KDM4A UHRF2	7.05e-04	95	79	4	PS50016
Domain	ZF_PHD_1	KMT2D ASXL3 KDM4A UHRF2	7.33e-04	96	79	4	PS01359
Domain	VDCCAlpha1	CACNA1C CACNA1G	7.78e-04	10	79	2	IPR002077
Domain	SET	SETDB1 KMT2D PRDM2	9.70e-04	46	79	3	SM00317
Domain	SET_dom	SETDB1 KMT2D PRDM2	1.24e-03	50	79	3	IPR001214
Domain	SET	SETDB1 KMT2D PRDM2	1.24e-03	50	79	3	PS50280
Domain	-	ARHGAP42 MTMR4 AFAP1 PLEKHG4 PLEKHG3 IQSEC1 ANKS1A	1.33e-03	391	79	7	2.30.29.30
Domain	TUDOR	TDRD5 AKAP1	1.56e-03	14	79	2	PF00567
Domain	Post-SET_dom	SETDB1 KMT2D	2.04e-03	16	79	2	IPR003616
Domain	PostSET	SETDB1 KMT2D	2.04e-03	16	79	2	SM00508
Domain	POST_SET	SETDB1 KMT2D	2.04e-03	16	79	2	PS50868
Domain	PH_dom-like	ARHGAP42 MTMR4 AFAP1 PLEKHG4 PLEKHG3 IQSEC1 ANKS1A	2.16e-03	426	79	7	IPR011993
Domain	Rib_L2_dom2	HERC2 UHRF2	2.59e-03	18	79	2	IPR014722
Domain	-	HERC2 UHRF2	2.59e-03	18	79	2	2.30.30.30
Domain	Ank	ANK2 ANKRD12 RIPK4 TEX14 ANKS1A	2.81e-03	228	79	5	PF00023
Domain	-	PIKFYVE KMT2D MTMR4 ZFYVE16 KDM4A UHRF2 MSL2	2.90e-03	449	79	7	3.30.40.10
Domain	Znf_RING/FYVE/PHD	PIKFYVE KMT2D MTMR4 ZFYVE16 KDM4A UHRF2 MSL2	3.27e-03	459	79	7	IPR013083
Domain	EPHD	KMT2D KDM4A	3.86e-03	22	79	2	PS51805
Domain	ANK	ANK2 ANKRD12 RIPK4 TEX14 ANKS1A	4.23e-03	251	79	5	SM00248
Domain	ANK_REPEAT	ANK2 ANKRD12 RIPK4 TEX14 ANKS1A	4.38e-03	253	79	5	PS50088
Domain	ANK_REP_REGION	ANK2 ANKRD12 RIPK4 TEX14 ANKS1A	4.45e-03	254	79	5	PS50297
Domain	Ankyrin_rpt	ANK2 ANKRD12 RIPK4 TEX14 ANKS1A	5.07e-03	262	79	5	IPR002110
Domain	DEATH	ANK2 TNFRSF21	5.79e-03	27	79	2	SM00005
Domain	PHD	KMT2D KDM4A UHRF2	6.37e-03	89	79	3	SM00249
Domain	PH	ARHGAP42 AFAP1 PLEKHG4 PLEKHG3 IQSEC1	6.49e-03	278	79	5	SM00233
Domain	PH_DOMAIN	ARHGAP42 AFAP1 PLEKHG4 PLEKHG3 IQSEC1	6.58e-03	279	79	5	PS50003
Domain	PH_domain	ARHGAP42 AFAP1 PLEKHG4 PLEKHG3 IQSEC1	6.68e-03	280	79	5	IPR001849
Domain	Znf_PHD	KMT2D KDM4A UHRF2	6.77e-03	91	79	3	IPR001965
Domain	Kinase-like_dom	PIM3 MAP3K14 RIPK4 TEX14 WNK4 WNK3 PRDM2	7.99e-03	542	79	7	IPR011009
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	RALGAPA1 WWC2 OPTN MTMR4 CDC42EP4 ALMS1 PLEKHG3 KIAA0232 MAP3K14 IQSEC1 APC AKAP1 WNK4 WNK3 ANKS1A	1.06e-09	861	80	15	36931259
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	RALGAPA1 ZNF609 AFAP1 NRXN3 SERTAD2 RPRD2 CACNA1G KDM4A CEP126 NACAD KIAA1614 ANKS1A	3.20e-09	529	80	12	14621295
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	SETDB1 ZNF609 KMT2D ALMS1 ZFHX4 ZFYVE16 ZNF644 APC AKAP1 PRDM2	4.40e-08	418	80	10	34709266
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	PIKFYVE RALGAPA1 SETDB1 ZNF609 MTMR4 ALMS1 ZFYVE16 APC PDZD8 RPRD2 AKAP1 ANKS1A	1.14e-07	733	80	12	34672954
Pubmed	Interaction network of human early embryonic transcription factors.	ZNF609 KMT2D ALMS1 ZFHX4 ASXL3 ZNF644 UBN2 UHRF2 PRDM2	1.21e-07	351	80	9	38297188
Pubmed	Genomic analysis of mouse retinal development.	DMTF1 MTMR4 CDC42EP4 KITLG ZFHX4 PDE4DIP PITPNM3 APC PDZD8 TRAK2 UBN2 RGS16 IMPG2	4.82e-07	1006	80	13	15226823
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	ZNF609 ALMS1 ZFYVE16 HERC2 NACAD	4.37e-06	104	80	5	9205841
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETDB1 ZFYVE16 KIAA0232 ZNF644 PDE4DIP ANKRD12 TRAK2 MAPKBP1	4.56e-06	407	80	8	12693553
Pubmed	WNKs are potassium-sensitive kinases.	WNK4 WNK3	5.23e-06	2	80	2	33439774
Pubmed	Proteomic identification of overexpressed adenomatous polyposis coli and cyclin B3 during endoderm differentiation from human embryonic stem cells.	CCNB3 APC	5.23e-06	2	80	2	21404461
Pubmed	Abnormal Peyer patch development and B-cell gut homing drive IgA deficiency in Kabuki syndrome.	KMT2D ITGB7	5.23e-06	2	80	2	31816409
Pubmed	WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.	WNK4 WNK3	5.23e-06	2	80	2	18701621
Pubmed	β7 integrins contribute to intestinal tumor growth in mice.	APC ITGB7	5.23e-06	2	80	2	30235302
Pubmed	Functional proteomics mapping of a human signaling pathway.	DMTF1 SETDB1 OPTN KMT2D MTMR4 ZFYVE16 PDE4DIP HERC2 UHRF2	8.83e-06	591	80	9	15231748
Pubmed	New nomenclature for chromatin-modifying enzymes.	SETDB1 KMT2D KDM4A PRDM2	9.34e-06	57	80	4	18022353
Pubmed	The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.	WNK4 WNK3	1.57e-05	3	80	2	17975670
Pubmed	Thyroid Carcinomas That Occur in Familial Adenomatous Polyposis Patients Recurrently Harbor Somatic Variants in APC, BRAF, and KTM2D.	KMT2D APC	1.57e-05	3	80	2	32024448
Pubmed	SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.	SETDB1 KDM4A	1.57e-05	3	80	2	30692626
Pubmed	Decreased cardiac L-type Ca²⁺ channel activity induces hypertrophy and heart failure in mice.	CACNA1C CACNA1G	1.57e-05	3	80	2	22133878
Pubmed	A macromolecular trafficking complex composed of β₂-adrenergic receptors, A-Kinase Anchoring Proteins and L-type calcium channels.	CACNA1C AKAP1	1.57e-05	3	80	2	23557075
Pubmed	APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane.	APC TRAK2	1.57e-05	3	80	2	26658612
Pubmed	T-type, but not L-type, voltage-gated calcium channels are dispensable for lymphatic pacemaking and spontaneous contractions.	CACNA1C CACNA1G	1.57e-05	3	80	2	31919478
Pubmed	Electric field stimulation unmasks a subtle role for T-type calcium channels in regulating lymphatic contraction.	CACNA1C CACNA1G	1.57e-05	3	80	2	37739992
Pubmed	Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.	WNK4 WNK3	3.13e-05	4	80	2	34384519
Pubmed	WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.	WNK4 WNK3	3.13e-05	4	80	2	11571656
Pubmed	Human hypertension caused by mutations in WNK kinases.	WNK4 WNK3	3.13e-05	4	80	2	11498583
Pubmed	Functional importance of L- and P/Q-type voltage-gated calcium channels in human renal vasculature.	CACNA1C CACNA1G	3.13e-05	4	80	2	21788606
Pubmed	MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer.	MAP9 APC	3.13e-05	4	80	2	31662330
Pubmed	SLC26A9 is a Cl(-) channel regulated by the WNK kinases.	WNK4 WNK3	3.13e-05	4	80	2	17673510
Pubmed	Identification of UHRF2 as a novel DNA interstrand crosslink sensor protein.	FANCD2 UHRF2	5.20e-05	5	80	2	30335751
Pubmed	Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.	WNK4 WNK3	5.20e-05	5	80	2	24641320
Pubmed	T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.	ANK2 CACNA1G	5.20e-05	5	80	2	29720258
Pubmed	The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase.	SETDB1 KDM4A	7.79e-05	6	80	2	37179361
Pubmed	UHRF2 promotes intestinal tumorigenesis through stabilization of TCF4 mediated Wnt/β-catenin signaling.	APC UHRF2	7.79e-05	6	80	2	32372448
Pubmed	Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.	MYCL DMTF1 ZNF609 URI1 KLF7 ZNF644 SERTAD2 KDM4A UHRF2	1.00e-04	808	80	9	20412781
Pubmed	Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	NRXN3 PLEKHG3 TRAK2 MAPKBP1	1.04e-04	105	80	4	9628581
Pubmed	Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.	WNK4 WNK3	1.09e-04	7	80	2	20525693
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1G	1.09e-04	7	80	2	12900400
Pubmed	Intestinal mast cell progenitors require CD49dbeta7 (alpha4beta7 integrin) for tissue-specific homing.	KITLG ITGB7	1.09e-04	7	80	2	11696590
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	AFAP1 ALMS1 APC TRAK2 ANKS1A	1.25e-04	209	80	5	36779422
Pubmed	KLHL2 interacts with and ubiquitinates WNK kinases.	WNK4 WNK3	1.45e-04	8	80	2	23838290
Pubmed	Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.	CACNA1C CACNA1G	1.45e-04	8	80	2	21737792
Pubmed	The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.	WNK4 WNK3	1.45e-04	8	80	2	23387299
Pubmed	IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.	WNK4 WNK3	1.45e-04	8	80	2	21317537
Pubmed	Intracellular calcium plays an essential role in cardiac development.	CACNA1C CACNA1G	1.45e-04	8	80	2	12761855
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	FANCD2 RALGAPA1 WWC2 ZNF609 URI1 KMT2D MTMR4 ZFYVE16 PDZD8 HERC2	1.45e-04	1049	80	10	27880917
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	CACNA1C CDC42EP4 ANK2 IQSEC1 PITPNM3 APC	1.53e-04	347	80	6	17114649
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	ALMS1 PDE4DIP APC HERC2	1.74e-04	120	80	4	31413325
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1G	1.86e-04	9	80	2	16382099
Pubmed	Genome wide association study of age at menarche in the Japanese population.	ARHGAP42 ZFHX4	1.86e-04	9	80	2	23667675
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	PIKFYVE ALMS1 PDE4DIP IQSEC1 NACAD	2.07e-04	233	80	5	37704626
Pubmed	A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract.	MYCL PIKFYVE DMTF1 KLF7 BARHL1 SERTAD2 KDM4A UHRF2	2.29e-04	709	80	8	22988430
Pubmed	Cav3.2 T-type calcium channel is required for the NFAT-dependent Sox9 expression in tracheal cartilage.	CACNA1C CACNA1G	2.32e-04	10	80	2	24778262
Pubmed	CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.	SETDB1 ZNF644	2.32e-04	10	80	2	19061646
Pubmed	Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development.	SETDB1 PRDM2	2.32e-04	10	80	2	23333759
Pubmed	RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain.	HERC2 ANKS1A	2.32e-04	10	80	2	29097665
Pubmed	Genetic determinants of hair, eye and skin pigmentation in Europeans.	KITLG HERC2	2.32e-04	10	80	2	17952075
Pubmed	Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.	DMTF1 CACNA1C	2.84e-04	11	80	2	20351715
Pubmed	IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine.	IL22RA2 APC	2.84e-04	11	80	2	23075849
Pubmed	Group 3 Innate Lymphoid Cells Program a Distinct Subset of IL-22BP-Producing Dendritic Cells Demarcating Solitary Intestinal Lymphoid Tissues.	IL22RA2 MAP3K14	3.40e-04	12	80	2	33207209
Pubmed	Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells.	KITLG MAP3K14	3.40e-04	12	80	2	20023630
Pubmed	The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes.	KMT2D APC	4.01e-04	13	80	2	16510874
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	FANCD2 WWC2 KMT2D ZNF644 IQSEC1 AKAP1 PRDM2 ANKS1A	4.10e-04	774	80	8	15302935
Pubmed	Human transcription factor protein interaction networks.	SETDB1 ZNF609 KMT2D ALMS1 ZFHX4 MRPS18B ZNF644 RPRD2 HERC2 UBN2 PRDM2	4.21e-04	1429	80	11	35140242
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	MAP9 AFAP1 ANK2	5.05e-04	67	80	3	29254152
Pubmed	Gene-specific requirement for P-TEFb activity and RNA polymerase II phosphorylation within the p53 transcriptional program.	KMT2D APC	5.38e-04	15	80	2	16510875
Pubmed	Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.	KITLG HERC2	5.38e-04	15	80	2	23548203
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RALGAPA1 CACNA1C ZNF609 URI1 KLF7 PLEKHG3 KIAA0232 RPRD2 ANKRD12 UBN2 ANKS1A	5.93e-04	1489	80	11	28611215
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	CACNA1C CACNA1G	6.95e-04	17	80	2	27725084
Pubmed	Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain.	ANK2 CACNA1G	7.81e-04	18	80	2	31910261
Pubmed	A global genomic transcriptional code associated with CNS-expressed genes.	URI1 ZFHX4 KLF7 UBN2 UHRF2	8.50e-04	318	80	5	16919269
Pubmed	Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.	CACNA1C ANK2	8.71e-04	19	80	2	24315451
Pubmed	Long QT Syndrome Overview	CACNA1C ANK2	8.71e-04	19	80	2	20301308
Pubmed	Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.	KITLG TEX14	8.71e-04	19	80	2	23666240
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	KMT2D ALMS1 RPRD2 ANKRD12	8.76e-04	184	80	4	32908313
Pubmed	A human MAP kinase interactome.	SETDB1 CDC42EP4 KIAA0232 APC HERC2 MSL2	9.06e-04	486	80	6	20936779
Pubmed	Meta-analysis identifies four new loci associated with testicular germ cell tumor.	KITLG TEX14	9.66e-04	20	80	2	23666239
Pubmed	Correct timing of proliferation and differentiation is necessary for normal inner ear development and auditory hair cell viability.	MYCL BARHL1	9.66e-04	20	80	2	23193000
Pubmed	Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.	KMT2D ASXL3	9.66e-04	20	80	2	29785026
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	MYCL PIKFYVE PIM3 KMT2D PDZD8 HERC2 MAPKBP1 TNFRSF21 RGS16	9.82e-04	1105	80	9	35748872
Pubmed	Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.	NRXN3 KDM4A	1.07e-03	21	80	2	22959728
Pubmed	Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.	KMT2D KDM4A	1.07e-03	21	80	2	27626377
Pubmed	A census of human transcription factors: function, expression and evolution.	MYCL DMTF1 KMT2D HOXC12 ZFHX4 BARHL1 ZNF644 PRDM2	1.16e-03	908	80	8	19274049
Pubmed	Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.	SETDB1 KDM4A	1.17e-03	22	80	2	28963472
Pubmed	Integrated proteogenetic analysis reveals the landscape of a mitochondrial-autophagosome synapse during PARK2-dependent mitophagy.	OPTN MTMR4 AKAP1	1.57e-03	99	80	3	31723608
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	GABRQ ITGB7 IMPG2	1.66e-03	101	80	3	23382219
Pubmed	Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIAA1614 WNK3 MSL2	1.66e-03	101	80	3	10997877
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ANK2 PDE4DIP IQSEC1 APC HERC2 UBN2 WNK3 ANKS1A	1.68e-03	963	80	8	28671696
Pubmed	Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray.	CACNA1C ANK2 MRPS18B PDE4DIP HERC2	1.68e-03	371	80	5	15747579
Pubmed	Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.	ZNF644 IQSEC1 RPRD2 UBN2	1.75e-03	222	80	4	37071664
Pubmed	Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.	KIAA1210 CFAP92 ZNF644	1.76e-03	103	80	3	10574462
Pubmed	Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.	ARHGAP42 HERC2 REELD1	1.76e-03	103	80	3	11752456
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	ALMS1 KIAA0232 RPRD2 CACNA1G	1.84e-03	225	80	4	12168954
Pubmed	Identification of Arx transcriptional targets in the developing basal forebrain.	KITLG PDE4DIP	1.90e-03	28	80	2	18799476
Pubmed	Large-scale concatenation cDNA sequencing.	DMTF1 CACNA1C OPTN ANK2 IQSEC1 APC	2.00e-03	568	80	6	9110174
Pubmed	A "double adaptor" method for improved shotgun library construction.	DMTF1 CACNA1C OPTN ANK2 IQSEC1 APC	2.11e-03	574	80	6	8619474
Pubmed	Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons.	KITLG KLF7	2.18e-03	30	80	2	31399471
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	ZNF609 KMT2D ZFHX4 APC PRDM2	2.28e-03	398	80	5	35016035
Interaction	PIAS4 interactions	FANCD2 SETDB1 OPTN PLEKHG4 ZNF644 PDE4DIP HERC2	4.81e-06	173	78	7	int:PIAS4
Cytoband	17q22	CACNA1G TEX14 AKAP1	6.41e-05	44	80	3	17q22
Cytoband	11q22.1	ARHGAP42 CEP126	2.69e-04	14	80	2	11q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr17q22	MTMR4 TEX14 AKAP1	5.03e-04	88	80	3	chr17q22
Cytoband	Ensembl 112 genes in cytogenetic band chr11q22	ARHGAP42 CEP126 MMP20	8.88e-04	107	80	3	chr11q22
GeneFamily	Tudor domain containing	TDRD5 SETDB1 KDM4A UHRF2 AKAP1	4.84e-08	37	49	5	780
GeneFamily	Zinc fingers FYVE-type\|Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors	PIKFYVE MTMR4 ZFYVE16	7.97e-05	31	49	3	81
GeneFamily	Zinc fingers C2H2-type\|Lysine methyltransferases\|PR/SET domain family	SETDB1 KMT2D PRDM2	1.06e-04	34	49	3	487
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	URI1 CSRNP3 ZFYVE16 APC AKAP1	1.27e-04	181	49	5	694
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1G	2.24e-03	26	49	2	253
GeneFamily	Ankyrin repeat domain containing	ANK2 ANKRD12 RIPK4 ANKS1A	4.14e-03	242	49	4	403
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBML5	OPTN NRXN3 ANK2 ZFHX4 KLF7 CSRNP3 ASXL3 APC CACNA1G CEP126 UBN2 AKAP1	1.47e-08	465	79	12	M39066
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	CACNA1C OPTN NRXN3 ANK2 ZFHX4 KLF7 CSRNP3 ASXL3 PDE4DIP APC CACNA1G ANKRD12 CEP126 UBN2 WNK3 SOCS7 PRDM2	2.55e-08	1106	79	17	M39071
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HNBGABA	CACNA1C OPTN NRXN3 ANK2 ZFHX4 CSRNP3 ASXL3 PDE4DIP CACNA1G ANKRD12 UBN2 AKAP1 SOCS7	1.73e-07	703	79	13	M39070
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HDA	OPTN NRXN3 ANK2 KLF7 CSRNP3 PDE4DIP ANKRD12 CEP126 AKAP1	2.15e-05	506	79	9	M39067
Coexpression	GSE42021_TCONV_PLN_VS_TREG_PRECURSORS_THYMUS_UP	PLEKHG3 KIAA0232 SERTAD2 IQSEC1 PDZD8 TRAK2	3.03e-05	198	79	6	M9571
Coexpression	GSE41867_DAY6_EFFECTOR_VS_DAY30_MEMORY_CD8_TCELL_LCMV_ARMSTRONG_DN	DMTF1 KLF7 APC RPRD2 ITGB7 PRDM2	3.20e-05	200	79	6	M9459
Coexpression	HE_LIM_SUN_FETAL_LUNG_C1_GHRL_POS_NE_PRECURSOR_CELL	AP1AR OPTN ANK2 IQSEC1 CEP126 MAPKBP1 TNFRSF21 NACAD	4.56e-05	429	79	8	M45694
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_top-relative-expression-ranked_500	SETDB1 KITLG ZFHX4 CSRNP3 SERTAD2 ERCC6L2 APC RIPK4 HERC2	1.66e-05	408	77	9	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_top-relative-expression-ranked_1000	MAP9 SETDB1 NRXN3 KITLG ANK2 ZFHX4 CSRNP3 ASXL3 ERCC6L2 APC RPRD2 HERC2	3.62e-05	818	77	12	DevelopingLowerUrinaryTract_e14.5_ urogenital sinus_emap-6689_1000
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#5_top-relative-expression-ranked_500	SETDB1 KITLG SERTAD2 ERCC6L2 APC HERC2	7.45e-05	194	77	6	DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k5_500
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW26-Neuronal-GABAergic_neurons\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1C NRXN3 KLF7 CSRNP3 ASXL3 PDE4DIP ANKRD12 UBN2 NACAD SOCS7	3.02e-12	200	80	10	bad32a95b759fad509401b07bc96a56687c2a592
ToppCell	TCGA-Pancreas-Primary_Tumor-Pancreatic_Adenocarcinoma-Ductal_Adenocarcinoma-1\|TCGA-Pancreas / Sample_Type by Project: Shred V9	ARHGAP42 KITLG ALMS1 ZNF644 APC ANKRD12	1.07e-06	186	80	6	03db813598b67b1e08f759758a1c2023396921fa
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW26-Neuronal\|GW26 / Sample Type, Dataset, Time_group, and Cell type.	OPTN KLF7 CSRNP3 ASXL3 PDE4DIP ANKRD12	1.64e-06	200	80	6	306926cb7a847871641f02e03d52dc56fd55711c
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	OPTN NRXN3 KLF7 PDE4DIP ANKRD12	1.81e-06	112	80	5	9c3fb470708e76a8f8a3cb9aa17ab130c60fee11
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	MYCL ZFYVE16 ASXL3 ZNF644 KDM4A	7.33e-06	149	80	5	768877bade04ca0321593b8470b5011ad8270431
ToppCell	Int-URO-Myeloid-tDC\|Int-URO / Disease, Lineage and Cell Type	MAP9 IL22RA2 AKAP1 TNFRSF21 RGS16	1.20e-05	165	80	5	9803c3db6cdcf925bea7d9c382bf4fd05acf3509
ToppCell	facs-Marrow-KLS-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL FNDC7 MTMR4 LRRC25 ITGB7	1.73e-05	178	80	5	6bad4439a1692332f70135ff446a1048fa4c399d
ToppCell	facs-Marrow-KLS-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL FNDC7 MTMR4 LRRC25 ITGB7	1.73e-05	178	80	5	3f6feb4ed7779cf5684f52939350b41d7718c3c6
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NRXN3 ANK2 ZFHX4 NACAD RGS16	2.25e-05	188	80	5	dc52dd2957be3f40001f0a56f3d9ac9d66ea466e
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NRXN3 ANK2 ZFHX4 NACAD RGS16	2.25e-05	188	80	5	2ef08313087e91985bcffc46c3798470cdeec49c
ToppCell	droplet-Lung-1m-Endothelial-lymphatic_endothelial-lymphatic_endothelial_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NRXN3 ANK2 ZFHX4 NACAD RGS16	2.25e-05	188	80	5	1f1604b6dc0a8ad0be3d9aac0bef448459c22465
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 CACNA1C AFAP1 ANK2 RGS16	2.37e-05	190	80	5	45df8fee00f8949937863159d7aa042e72748d9b
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 CACNA1C AFAP1 ANK2 RGS16	2.49e-05	192	80	5	df1545670370fb1010c567cd059c2783eab315f7
ToppCell	LPS_only-Stromal_mesenchymal\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 CACNA1C AFAP1 ANK2 RGS16	2.49e-05	192	80	5	162d8b5858d150ecbbd1c9bf2b19c6c9cd50a158
ToppCell	LPS-IL1RA-Stromal_mesenchymal\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP42 CACNA1C AFAP1 ANK2 RGS16	2.49e-05	192	80	5	4e47a02007f562f29ba5910df64d32a0167d0bd1
ToppCell	wk_08-11-Hematologic-Meg-ery-Definitive_erythroblast\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	KIAA0232 SERTAD2 IQSEC1 TRAK2 RSC1A1	2.55e-05	193	80	5	be75abfdf5301cf33df8ee9ed92504d44fdf19a6
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	NRXN3 PDE4DIP APC ANKRD12 ANKS1A	2.62e-05	194	80	5	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	NRXN3 PDE4DIP APC ANKRD12 ANKS1A	2.62e-05	194	80	5	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	moderate-Epithelial-FOXN4+\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	MYCL MAP9 KITLG ALMS1 CEP126	2.62e-05	194	80	5	5dffa578149104dda33774361e9e77b227b5f1ce
ToppCell	droplet-Mammary_Gland-nan-3m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYCL NRXN3 CDC42EP4 PLEKHG3 APC	2.62e-05	194	80	5	715e02e5f3250b1bfdc26b7dfd656ba4e705ea84
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	OPTN NRXN3 KLF7 PDE4DIP	2.72e-05	96	80	4	56e993d37b7958abe56682422536045550e29b41
ToppCell	(5)_Fibroblast-J_(Lipofibroblast)\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	AFAP1 CDC42EP4 ANK2 ZFHX4 RGS16	2.75e-05	196	80	5	afa29399decd17fda7d63add5039ff778627ccc2
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-Neuronal-midbrain/hindbrain_cells\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	OPTN AFAP1 ANK2 KLF7 RGS16	2.82e-05	197	80	5	c7078f6fcf27319ba8c5ebe700bcae7f1e7e39c1
ToppCell	(11)_FOXN4+-(2)_GFP_FOXI1\|(11)_FOXN4+ / shred by cell type by condition	MAP9 KITLG ZNF644 ANKRD12 TRAK2	2.89e-05	198	80	5	76d40b8c2f8399725b3a62ee2ae0896559cf91eb
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M\|organoid_Kanton_Nature / Sample Type, Dataset, Time_group, and Cell type.	AFAP1 KIAA0232 PDE4DIP APC ANKRD12	2.96e-05	199	80	5	b2d7dea11207cca63d688f8051143850b29dbdf0
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW09-Neuronal-Cortical_neuron\|GW09 / Sample Type, Dataset, Time_group, and Cell type.	OPTN KLF7 CSRNP3 ASXL3 PDE4DIP	3.03e-05	200	80	5	44bc4d6616fc8d0ad8498e56125939034e8cff01
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal-Interneuron\|10w / Sample Type, Dataset, Time_group, and Cell type.	NRXN3 ZFHX4 CSRNP3 ASXL3 CACNA1G	3.03e-05	200	80	5	f5c63ef52bd7a898cf009b8bf9b2f7f4890d1c9b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-10w-Neuronal\|10w / Sample Type, Dataset, Time_group, and Cell type.	NRXN3 ANK2 ZFHX4 CSRNP3 ASXL3	3.03e-05	200	80	5	979258173b82f37aeaaedd53b4a527da1dbe1b80
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW10-Neuronal-Interneuron\|GW10 / Sample Type, Dataset, Time_group, and Cell type.	CACNA1C NRXN3 CSRNP3 PDE4DIP	7.87e-05	126	80	4	ec445ec097c9c45cd47b8cfa8c140df5b298695e
Drug	H-7 dihydrochloride; Down 200; 100uM; MCF7; HT_HG-U133A	PIKFYVE KIAA0232 SERTAD2 ANKRD12 RIPK4 RGS16 MSL2	4.25e-06	189	79	7	5936_DN
Drug	Daunorubicin hydrochloride [23541-50-6]; Down 200; 7uM; MCF7; HT_HG-U133A	KIAA0232 SERTAD2 ANKRD12 RIPK4 RGS16 PRDM2 MSL2	4.40e-06	190	79	7	4983_DN
Drug	wortmannin; Down 200; 0.01uM; ssMCF7; HG-U133A	MYCL WWC2 OPTN PDE4DIP APC PDZD8 TNFRSF21	5.97e-06	199	79	7	404_DN
Drug	LY 294002; Up 200; 10uM; HL60; HT_HG-U133A	RALGAPA1 OPTN PDE4DIP IQSEC1 CACNA1G PRDM2	5.87e-05	194	79	6	6195_UP
Drug	semustine; Down 200; 100uM; MCF7; HT_HG-U133A	RALGAPA1 WWC2 ZNF609 KLF7 PDE4DIP RGS16	6.04e-05	195	79	6	7540_DN
Drug	Pirenzepine dihydrochloride [29868-97-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	AFAP1 PLEKHG3 APC KDM4A MAPKBP1 PRDM2	6.04e-05	195	79	6	2234_DN
Drug	Iohexol [66108-95-0]; Up 200; 4.8uM; MCF7; HT_HG-U133A	CACNA1C PDE4DIP CACNA1G TEX14 MAPKBP1 IMPG2	6.22e-05	196	79	6	5704_UP
Drug	Fenofibrate [49562-28-9]; Up 200; 11uM; MCF7; HT_HG-U133A	MYCL ZNF609 ZFYVE16 PLEKHG3 PDE4DIP RIPK4	6.22e-05	196	79	6	7432_UP
Drug	Ajmaline [4360-12-7]; Up 200; 12.2uM; MCF7; HT_HG-U133A	MAP9 ZNF609 AFAP1 KITLG PDE4DIP APC	6.40e-05	197	79	6	7484_UP
Drug	Ondansetron Hydrochloride [103639-04-9]; Down 200; 12.2uM; PC3; HT_HG-U133A	MYCL SETDB1 ZNF609 CSRNP3 PDE4DIP KDM4A	6.40e-05	197	79	6	5796_DN
Drug	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2; Down 200; 10uM; PC3; HT_HG-U133A	RALGAPA1 SETDB1 WWC2 APC ANKRD12 MSL2	6.58e-05	198	79	6	7557_DN
Drug	Sulfadoxine [2447-57-6]; Down 200; 12.8uM; PC3; HT_HG-U133A	ZNF609 KLF7 PLEKHG3 KIAA0232 AKAP1 PRDM2	6.58e-05	198	79	6	5852_DN
Drug	Bromopride [4093-35-0]; Down 200; 11.6uM; MCF7; HT_HG-U133A	OPTN AFAP1 KITLG ZFHX4 PDE4DIP APC	6.58e-05	198	79	6	6037_DN
Drug	butein; Down 200; 10uM; MCF7; HG-U133A	ANK2 PLEKHG3 PDE4DIP IQSEC1 ANKRD12 TNFRSF21	6.58e-05	198	79	6	607_DN
Drug	Mefenamic acid [61-68-7]; Up 200; 16.6uM; HL60; HT_HG-U133A	ZNF609 CDC42EP4 ZFYVE16 APC PRDM2 ANKS1A	6.76e-05	199	79	6	1863_UP
Drug	Alfuzosin hydrochloride [81403-68-1]; Down 200; 9.4uM; MCF7; HT_HG-U133A	MYCL ZNF609 KLF7 PLEKHG3 PDE4DIP TNFRSF21	6.76e-05	199	79	6	3203_DN
Drug	N6,2'-O-Dibutyryladenosine 3',5'-cyclic monophosphate sodium salt; Up 200; 20uM; MCF7; HG-U133A	ZNF609 PLEKHG3 MAP3K14 IQSEC1 TNFRSF21 PRDM2	6.95e-05	200	79	6	591_UP
Disease	matrilysin measurement	ARHGAP42 CEP126 MMP20	1.84e-07	5	79	3	EFO_0008227
Disease	pseudohypoaldosteronism (implicated_via_orthology)	WNK4 WNK3	1.05e-04	6	79	2	DOID:4479 (implicated_via_orthology)
Disease	underweight body mass index status	NRXN3 ANK2	2.52e-04	9	79	2	EFO_0005936
Disease	schizophrenia, anorexia nervosa	CACNA1C ALMS1 RPRD2	2.93e-04	48	79	3	MONDO_0005090, MONDO_0005351
Disease	pigmentation disease (is_implicated_in)	KITLG HERC2	3.83e-04	11	79	2	DOID:10123 (is_implicated_in)
Disease	open-angle glaucoma (is_implicated_in)	OPTN AFAP1	4.59e-04	12	79	2	DOID:1067 (is_implicated_in)
Disease	amyotrophic lateral sclerosis, age at onset	NRXN3 KDM4A	7.27e-04	15	79	2	EFO_0004847, MONDO_0004976
Disease	R-warfarin measurement	CACNA1C NRXN3 ANK2 CSRNP3 PLEKHG3	7.38e-04	265	79	5	EFO_0803324
Disease	synophrys measurement	ZFHX4 ERCC6L2 HERC2	8.17e-04	68	79	3	EFO_0007906
Disease	T-Cell Lymphoma	KMT2D ASXL3	8.29e-04	16	79	2	C0079772
Disease	unipolar depression, bipolar disorder	DMTF1 CACNA1C ASXL3 RPRD2	8.30e-04	156	79	4	EFO_0003761, MONDO_0004985
Disease	Anhedonia	CACNA1C SETDB1	1.88e-03	24	79	2	C0178417
Disease	Brugada Syndrome (disorder)	CACNA1C ANK2	1.88e-03	24	79	2	C1142166
Disease	complement factor D measurement	PIKFYVE ZNF609 SERTAD2	2.02e-03	93	79	3	EFO_0020283
Disease	colorectal health	NRXN3 PITPNM3 HERC2 ANKS1A	2.11e-03	201	79	4	EFO_0008460
Disease	interleukin 5 measurement	SETDB1 NRXN3	2.56e-03	28	79	2	EFO_0008185

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSDSSTLPKLEEFCT	TDRD5	836	Q8NAT2
LEDSCTETSSSPRDK	AKAP1	516	Q92667
LENSPISSCDTSDTE	AFAP1	676	Q8N556
LELSPRSESSSDCSS	BARHL1	36	Q9BZE3
SNTSSDCRPSEESEL	ALMS1	3731	Q8TCU4
DCRPSEESELLTDTT	ALMS1	3736	Q8TCU4
SDSDLLTCSPTEDAT	ANKS1A	626	Q92625
DATVLTPNTESSCDL	AP1AR	176	Q63HQ0
SDSDRPCSSIESSSE	CFAP92	46	Q9ULG3
TESEFLPESSSVKSC	ANKRD12	586	Q6UB98
LSSEDDQSIDDSTPC	DMTF1	56	Q9Y222
ETQSTSEESCTPASL	ASXL3	631	Q9C0F0
SEESCTPASLETTFC	ASXL3	636	Q9C0F0
TESSACESASDKPVS	CCNB3	1086	Q8WWL7
SSSSDPDADCSVDVD	ANK2	2621	Q01484
PSCQSLESDSSSSLL	HOXC12	161	P31275
ENLDPEDSCLTSLAS	MAP9	231	Q49MG5
FEDCSSSEATTPVAV	HERC2	2426	O95714
DTTPACTLSALECDT	FNDC7	416	Q5VTL7
EKDSSSESEDSCPPS	GABRQ	571	Q9UN88
RESDSLEPSCTVSSA	LRRC25	16	Q8N386
DKADTDTSCRSTPSL	IQSEC1	351	Q6DN90
DTVCPAEVDSALDST	KIAA1614	601	Q5VZ46
SPCSSVRESDDEVSS	CSRNP3	16	Q8WYN3
STDTSSPKDCNSESE	KIAA0232	216	Q92628
VTSETSCPTKDSSDD	PDZD8	661	Q8NEN9
SIQPTSDDLVSSAEC	NRXN3	1306	Q9Y4C0
SSDDEDFVECEPSTT	NRXN3	1321	Q9Y4C0
ISSDSETSEPLSCRA	KDM4A	521	O75164
LSCDLTSETSDIQEP	IL22RA2	116	Q969J5
SETCLSLQPASSSLD	KLF7	106	O75840
EETEKPSDSSFTLCL	MSL2	141	Q9HCI7
MDDLLSACDTSSPLT	MTMR4	611	Q9NYA4
CECSVAELSSPDLES	ITGB7	511	P26010
LSDSACSVSVLDPSE	PIKFYVE	236	Q9Y2I7
HDTEACSEPSLLSTE	CACNA1C	1926	Q13936
VSEPSCSLALTDDSL	CACNA1G	1991	O43497
ESSSPLSNACSDLVT	CEP126	856	Q9P2H0
DSSSLSSCTSGILEE	CDC42EP4	306	Q9H3Q1
SCLSSPEHPTEDSES	MAPKBP1	1006	O60336
NTSDDCSSSEEDLPL	KIAA1210	861	Q9ULL0
SDDESSDEQPTCLST	ERCC6L2	826	Q5T890
SVESAEESCPSITAA	RSC1A1	341	Q92681
RVSSSCLDLPDSTEE	RPRD2	1066	Q5VT52
SSDTLSEEKNSECDP	FANCD2	881	Q9BXW9
TSEETLEDCSEVTPA	PRDM2	326	Q13029
SCLSIDSLSLSDDSE	MAP3K14	796	Q99558
LSCLTEKEDSPSEST	OPTN	6	Q96CV9
SIPDLCDSSSSFDAV	MMP20	291	O60882
ATCSDTSESILEEEP	URI1	446	O94763
CSPESSEDITDEFLT	TEX14	1071	Q8IWB6
VDESEPLLRCDSTSS	TNFRSF21	551	O75509
LTAEDSEISSQCPSA	PLEKHG4	1151	Q58EX7
DAESDCQSVASVTSP	ARHGAP42	696	A6NI28
SATDSLSCQLSPEVD	PLEKHG3	656	A1L390
SIQPTSDDLVSSAEC	NRXN3	301	Q9HDB5
LSEESSALDLPSACD	SHLD1	11	Q8IYI0
SDCVVSSTLSPEKDS	KITLG	161	P21583
ESEDFLSIDSLPSSS	IMPG2	521	Q9BZV3
DDPSFDSLETCLSSD	REELD1	306	A0A1B0GV85
LSSPQEITSETEDLC	RIPK4	321	P57078
ESDAPCSSDSSGVDL	SETDB1	871	Q15047
SCSSSLSALSLDEPF	APC	1501	P25054
SVPSTSNSDCVAADE	UHRF2	191	Q96PU4
ASEESETDSSCSTPL	TRAK2	181	O60296
TLCTKAPSEEDSLSS	MRPS18B	31	Q9Y676
QTSLPTESCSDESDS	ZFHX4	3516	Q86UP3
SSSAPAQETICLDDS	UBN2	741	Q6ZU65
LPEDSSCTEDLSSCT	WWC2	916	Q6AWC2
REPSSSSLCSIDEEH	RALGAPA1	376	Q6GYQ0
CSGSESPSDSENEEI	MYCL	156	P12524
SALDEIEELCPTSTS	SERTAD2	171	Q14140
DVALSEDSCSVLSEP	SOGA1	316	O94964
STSSDCKLPTSEESR	ZNF609	1186	O15014
AASATLSSCSLDEPS	RGS16	186	O15492
LDPDDVASTTSSSES	PIM3	311	Q86V86
DTPVAVEEDCSLASS	PITPNM3	301	Q9BZ71
SLETNSCSEEELSSP	SOCS7	126	O14512
CEESDSESPATFSTE	ZNF644	391	Q9H582
SSLCLSSEESESSGE	WNK4	1116	Q96J92
DTPCVSSTDHDSDTV	ZFYVE16	171	Q7Z3T8
IDSPFSSSAEDTLSC	WNK3	1141	Q9BYP7
SLRLCTDSLPETDDS	KMT2D	1256	O14686
TDSLPETDDSLLCDA	KMT2D	1261	O14686
SAVATEASLDSCPES	NACAD	1141	O15069
SPSSTSFLSDELEAC	PDE4DIP	1606	Q5VU43