Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	ALG10B ALG10	2.65e-06	2	33	2	GO:0106073
GeneOntologyMolecularFunction	glucosyltransferase activity	UGT8 ALG10B ALG10	6.20e-06	22	33	3	GO:0046527
GeneOntologyMolecularFunction	cyclin-dependent protein kinase activity	CDK2 CDK3 CDK7	1.62e-05	30	33	3	GO:0097472
GeneOntologyMolecularFunction	cyclin-dependent protein serine/threonine kinase activity	CDK2 CDK3 CDK7	1.62e-05	30	33	3	GO:0004693
GeneOntologyMolecularFunction	serine-type peptidase activity	RHBDD2 DPP10 RHBDF2 PRSS41 TMPRSS11D	2.14e-05	207	33	5	GO:0008236
GeneOntologyMolecularFunction	serine hydrolase activity	RHBDD2 DPP10 RHBDF2 PRSS41 TMPRSS11D	2.40e-05	212	33	5	GO:0017171
GeneOntologyMolecularFunction	serine-type endopeptidase activity	RHBDD2 RHBDF2 PRSS41 TMPRSS11D	2.62e-04	190	33	4	GO:0004252
GeneOntologyMolecularFunction	peptidase activity	RHBDD2 DPP10 RHBDF2 PRSS41 PIGK TMPRSS11D	6.28e-04	654	33	6	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	RHBDD2 RHBDF2 PRSS41 PIGK TMPRSS11D	6.53e-04	430	33	5	GO:0004175
GeneOntologyMolecularFunction	histone kinase activity	ATM CDK2	9.75e-04	28	33	2	GO:0035173
GeneOntologyMolecularFunction	cyclin binding	CDK2 CDK3	1.52e-03	35	33	2	GO:0030332
GeneOntologyMolecularFunction	protein serine kinase activity	ATM CDK2 CDK3 CDK7	2.90e-03	363	33	4	GO:0106310
GeneOntologyMolecularFunction	lipid transporter activity	PITPNM1 XKR4 ABCA13	4.09e-03	196	33	3	GO:0005319
GeneOntologyMolecularFunction	hexosyltransferase activity	UGT8 ALG10B ALG10	5.02e-03	211	33	3	GO:0016758
GeneOntologyMolecularFunction	protein serine/threonine kinase activity	ATM CDK2 CDK3 CDK7	6.02e-03	446	33	4	GO:0004674
GeneOntologyMolecularFunction	phospholipid transporter activity	PITPNM1 XKR4	6.64e-03	74	33	2	GO:0005548
GeneOntologyMolecularFunction	kinase activity	ATM SGMS1 CDK2 CDK3 CDK7	7.89e-03	764	33	5	GO:0016301
GeneOntologyMolecularFunction	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	HINT3 ACER1	7.91e-03	81	33	2	GO:0016811
GeneOntologyMolecularFunction	glycosyltransferase activity	UGT8 ALG10B ALG10	1.18e-02	288	33	3	GO:0016757
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PITPNM1 RHBDD2 UGT8 TMEM151A ACER1 SGMS1 RHBDF2 PIGK VPS13C ALG10B ALG10 MARCHF2	3.13e-07	1293	33	12	GO:0005789
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PITPNM1 RHBDD2 UGT8 TMEM151A ACER1 SGMS1 RHBDF2 PIGK VPS13C ALG10B ALG10 MARCHF2	3.29e-07	1299	33	12	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PITPNM1 RHBDD2 UGT8 TMEM151A ACER1 SGMS1 RHBDF2 PIGK VPS13C ALG10B ALG10 MARCHF2	4.14e-07	1327	33	12	GO:0042175
GeneOntologyCellularComponent	cyclin-dependent protein kinase holoenzyme complex	CDK2 CDK3 CDK7	1.21e-04	61	33	3	GO:0000307
GeneOntologyCellularComponent	serine/threonine protein kinase complex	CDK2 CDK3 CDK7	1.92e-03	157	33	3	GO:1902554
GeneOntologyCellularComponent	protein kinase complex	CDK2 CDK3 CDK7	2.41e-03	170	33	3	GO:1902911
Domain	Alg10	ALG10B ALG10	2.84e-06	2	32	2	IPR016900
Domain	DIE2_ALG10	ALG10B ALG10	2.84e-06	2	32	2	PF04922
Domain	-	RHBDD2 RHBDF2	1.02e-04	9	32	2	1.20.1540.10
Domain	Rhomboid	RHBDD2 RHBDF2	1.02e-04	9	32	2	PF01694
Domain	Peptidase_S54_rhomboid_dom	RHBDD2 RHBDF2	1.02e-04	9	32	2	IPR022764
Domain	TRYPSIN_SER	PRSS41 TMPRSS11D	1.04e-02	90	32	2	IPR033116
Domain	Kinase-like_dom	ATM CDK2 CDK3 CDK7	1.32e-02	542	32	4	IPR011009
Domain	TRYPSIN_HIS	PRSS41 TMPRSS11D	1.34e-02	103	32	2	IPR018114
Domain	TRYPSIN_SER	PRSS41 TMPRSS11D	1.42e-02	106	32	2	PS00135
Domain	TRYPSIN_HIS	PRSS41 TMPRSS11D	1.44e-02	107	32	2	PS00134
Pathway	BIOCARTA_EFP_PATHWAY	CDK2 CDK3 CDK7	1.39e-06	13	25	3	MM1537
Pathway	BIOCARTA_EFP_PATHWAY	CDK2 CDK3 CDK7	2.72e-06	16	25	3	M22011
Pathway	WP_SPHINGOLIPID_PATHWAY	UGT8 ACER1 SGMS1	1.94e-05	30	25	3	M39501
Pathway	KEGG_SPHINGOLIPID_METABOLISM	UGT8 ACER1 SGMS1	4.32e-05	39	25	3	M15955
Pathway	KEGG_MEDICUS_REFERENCE_N_GLYCAN_PRECURSOR_BIOSYNTHESIS_ALG6_TO_OST	ALG10B ALG10	1.64e-04	11	25	2	M47614
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	ATM CDK2 CDK7	1.66e-04	61	25	3	MM15912
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	ATM CDK2 CDK7	1.91e-04	64	25	3	M39627
Pathway	BIOCARTA_RB_PATHWAY	ATM CDK2	2.33e-04	13	25	2	M18159
Pathway	BIOCARTA_P53_PATHWAY	ATM CDK2	3.57e-04	16	25	2	M14863
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	UGT8 ACER1 SGMS1	5.58e-04	92	25	3	MM15086
Pathway	WP_METABOLISM_OF_SPHINGOLIPIDS_IN_ER_AND_GOLGI_APPARATUS	UGT8 SGMS1	6.21e-04	21	25	2	M39459
Pathway	WP_SYNTHESIS_OF_CERAMIDES_AND_1DEOXYCERAMIDES	UGT8 SGMS1	6.82e-04	22	25	2	M45544
Pathway	BIOCARTA_CELLCYCLE_PATHWAY	CDK2 CDK7	7.47e-04	23	25	2	M17770
Pathway	BIOCARTA_CELLCYCLE_PATHWAY	CDK2 CDK7	8.14e-04	24	25	2	MM1376
Pathway	REACTOME_SPHINGOLIPID_METABOLISM	UGT8 ACER1 SGMS1	8.66e-04	107	25	3	M14857
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	CDK2 CDK7	8.83e-04	25	25	2	MM15379
Pathway	REACTOME_CYCLIN_A_B1_B2_ASSOCIATED_EVENTS_DURING_G2_M_TRANSITION	CDK2 CDK7	8.83e-04	25	25	2	M808
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	UGT8 SGMS1	8.83e-04	25	25	2	MM15931
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	UGT8 SGMS1	9.56e-04	26	25	2	M39784
Pathway	WP_SPHINGOLIPID_METABOLISM_INTEGRATED_PATHWAY	UGT8 SGMS1	9.56e-04	26	25	2	MM15892
Pathway	WP_SPHINGOLIPID_METABOLISM_OVERVIEW	UGT8 SGMS1	1.03e-03	27	25	2	M39863
Pathway	BIOCARTA_G1_PATHWAY	ATM CDK2	1.11e-03	28	25	2	M648
Pathway	PID_BARD1_PATHWAY	ATM CDK2	1.19e-03	29	25	2	M258
Pathway	WP_CELL_CYCLE	ATM CDK2 CDK7	1.21e-03	120	25	3	M39650
Pathway	KEGG_CELL_CYCLE	ATM CDK2 CDK7	1.36e-03	125	25	3	M7963
Pathway	REACTOME_REGULATION_OF_TP53_DEGRADATION	ATM CDK2	1.83e-03	36	25	2	MM15339
Pathway	REACTOME_REGULATION_OF_TP53_EXPRESSION_AND_DEGRADATION	ATM CDK2	1.94e-03	37	25	2	M27641
Pathway	WP_ATM_SIGNALING	ATM CDK2	2.26e-03	40	25	2	M39433
Pathway	REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1	CDK2 CDK7	2.73e-03	44	25	2	MM15377
Pathway	KEGG_N_GLYCAN_BIOSYNTHESIS	ALG10B ALG10	2.98e-03	46	25	2	M11079
Pathway	REACTOME_CYCLIN_D_ASSOCIATED_EVENTS_IN_G1	CDK2 CDK7	3.11e-03	47	25	2	M29724
Pathway	PID_DELTA_NP63_PATHWAY	ATM WWP1	3.11e-03	47	25	2	M236
Pathway	WP_ATM_SIGNALING_IN_DEVELOPMENT_AND_DISEASE	ATM CDK2	3.11e-03	47	25	2	M39518
Pathway	WP_INTEGRATED_CANCER_PATHWAY	ATM CDK2	3.24e-03	48	25	2	M39628
Pubmed	Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death.	CDK2 CDK3 CDK7	6.51e-08	9	33	3	9438340
Pubmed	A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene.	CDK2 CDK3	8.73e-07	2	33	2	11172011
Pubmed	A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).	ALG10B ALG10	2.62e-06	3	33	2	24303013
Pubmed	Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4.	CDK2 CDK3	2.62e-06	3	33	2	12097586
Pubmed	Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation.	CDK2 CDK3	5.23e-06	4	33	2	9811456
Pubmed	In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.	CDK2 CDK7	5.23e-06	4	33	2	8521818
Pubmed	The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.	ALG10B ALG10	5.23e-06	4	33	2	14525949
Pubmed	Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.	CDK2 CDK7	5.23e-06	4	33	2	17386261
Pubmed	Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2.	CDK2 CDK3	5.23e-06	4	33	2	8242750
Pubmed	The histidine triad protein Hint is not required for murine development or Cdk7 function.	HINT3 CDK7	8.72e-06	5	33	2	12748294
Pubmed	Potent antimyeloma activity of a novel ERK5/CDK inhibitor.	CDK2 CDK7	8.72e-06	5	33	2	23532886
Pubmed	ATM and CDK2 control chromatin remodeler CSB to inhibit RIF1 in DSB repair pathway choice.	ATM CDK2	8.72e-06	5	33	2	29203878
Pubmed	Reciprocal activation by cyclin-dependent kinases 2 and 7 is directed by substrate specificity determinants outside the T loop.	CDK2 CDK7	1.31e-05	6	33	2	11113184
Pubmed	The crystal structure of human CDK7 and its protein recognition properties.	CDK2 CDK7	1.31e-05	6	33	2	15530371
Pubmed	The CDK inhibitor, p27Kip1, is required for IL-4 regulation of astrocyte proliferation.	CDK2 CDK7	1.31e-05	6	33	2	9218599
Pubmed	Novel HIV-1 therapeutics through targeting altered host cell pathways.	CDK2 CDK7	1.31e-05	6	33	2	19732026
Pubmed	Mechanism of Cdk2/Cyclin E inhibition by p27 and p27 phosphorylation.	CDK2 CDK7	1.31e-05	6	33	2	10393546
Pubmed	CDK4 T172 phosphorylation is central in a CDK7-dependent bidirectional CDK4/CDK2 interplay mediated by p21 phosphorylation at the restriction point.	CDK2 CDK7	1.83e-05	7	33	2	23737759
Pubmed	Interaction between Cdc37 and Cdk4 in human cells.	CDK2 CDK3	1.83e-05	7	33	2	9150368
Pubmed	Biochemical characterization of Cdk2-Speedy/Ringo A2.	CDK2 CDK7	2.44e-05	8	33	2	16191191
Pubmed	Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.	CDK2 CDK7	2.44e-05	8	33	2	16327805
Pubmed	Cdc25 phosphatases are required for timely assembly of CDK1-cyclin B at the G2/M transition.	CDK2 CDK7	2.44e-05	8	33	2	20360007
Pubmed	Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase.	CDK2 CDK3	2.44e-05	8	33	2	22654103
Pubmed	Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II.	CDK2 CDK7	2.44e-05	8	33	2	23064645
Pubmed	Alternative Functions of Cell Cycle-Related and DNA Repair Proteins in Post-mitotic Neurons.	ATM CDK2 CDK7	2.70e-05	61	33	3	34746147
Pubmed	P27Kip1 serine 10 phosphorylation determines its metabolism and interaction with cyclin-dependent kinases.	CDK2 CDK7	3.13e-05	9	33	2	25483085
Pubmed	BRCA1 can modulate RNA polymerase II carboxy-terminal domain phosphorylation levels.	CDK2 CDK7	3.13e-05	9	33	2	15282296
Pubmed	Effects of phosphorylation by CAK on cyclin binding by CDC2 and CDK2.	CDK2 CDK7	3.13e-05	9	33	2	7799941
Pubmed	Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H.	CDK2 CDK7	3.13e-05	9	33	2	8647086
Pubmed	Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.	CDK2 CDK7	3.13e-05	9	33	2	22505032
Pubmed	Detection of gene copy number aberrations in mantle cell lymphoma by a single quantitative multiplex PCR assay: clinicopathological relevance and prognosis value.	ATM CDK2	3.13e-05	9	33	2	19594747
Pubmed	Isolation and characterization of two human transcription factor IIH (TFIIH)-related complexes: ERCC2/CAK and TFIIH.	CDK2 CDK7	3.91e-05	10	33	2	8692841
Pubmed	PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.	ATM CDK3	3.91e-05	10	33	2	24550317
Pubmed	Both p16 and p21 families of cyclin-dependent kinase (CDK) inhibitors block the phosphorylation of cyclin-dependent kinases by the CDK-activating kinase.	CDK2 CDK7	3.91e-05	10	33	2	7629134
Pubmed	Regulated activating Thr172 phosphorylation of cyclin-dependent kinase 4(CDK4): its relationship with cyclins and CDK "inhibitors".	CDK2 CDK7	4.78e-05	11	33	2	16782892
Pubmed	Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry.	CDK2 CDK3 CDK7	5.64e-05	78	33	3	17192257
Pubmed	Human cyclin-dependent kinase-activating kinase exists in three distinct complexes.	CDK2 CDK7	5.73e-05	12	33	2	8692842
Pubmed	Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins.	CDK2 CDK3	5.73e-05	12	33	2	9840943
Pubmed	CDK10/cyclin M is a protein kinase that controls ETS2 degradation and is deficient in STAR syndrome.	CDK2 CDK3	5.73e-05	12	33	2	24218572
Pubmed	Human and mouse proteases: a comparative genomic approach.	RHBDD2 RHBDF2 PRSS41	6.31e-05	81	33	3	12838346
Pubmed	Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation.	CDK2 CDK3	7.89e-05	14	33	2	9190208
Pubmed	HIV-1 Tat-associated RNA polymerase C-terminal domain kinase, CDK2, phosphorylates CDK7 and stimulates Tat-mediated transcription.	CDK2 CDK7	9.10e-05	15	33	2	12049628
Pubmed	The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.	CDK2 CDK7	1.18e-04	17	33	2	16109376
Pubmed	Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes.	ATM CDK2	1.18e-04	17	33	2	12036888
Pubmed	Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium.	ATM CDK2	1.64e-04	20	33	2	26023099
Pubmed	The Role of CDKs and CDKIs in Murine Development.	CDK2 CDK3	1.81e-04	21	33	2	32731332
Pubmed	Functional genetic analysis of mouse chromosome 11.	ALG10B ALG10	2.18e-04	23	33	2	12955145
Pubmed	A human primary T-lymphocyte-derived human immunodeficiency virus type 1 Tat-associated kinase phosphorylates the C-terminal domain of RNA polymerase II and induces CAK activity.	CDK2 CDK7	2.18e-04	23	33	2	9311822
Pubmed	Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development.	ACER1 SGMS1	3.02e-04	27	33	2	23096701
Pubmed	Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.	UGT8 SGMS1	3.02e-04	27	33	2	25269881
Pubmed	Heart neurons use clock genes to control myocyte proliferation.	ATM CDK2	5.69e-04	37	33	2	34851661
Pubmed	Cell cycle genes and ovarian cancer susceptibility: a tagSNP analysis.	CDK2 CDK7	6.33e-04	39	33	2	19738611
Pubmed	Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.	CDK2 CDK7	7.00e-04	41	33	2	17276355
Pubmed	Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming.	CDK2 CDK7	8.43e-04	45	33	2	36220812
Interaction	CCNO interactions	CDK2 CDK3 CDK7	1.44e-05	31	31	3	int:CCNO
Interaction	CDKN1C interactions	CDK2 CDK3 CDK7	3.38e-05	41	31	3	int:CDKN1C
Interaction	CCNE1 interactions	TOP3B CDK2 CDK3 CDK7	3.43e-05	121	31	4	int:CCNE1
Interaction	KCNH2 interactions	TOP3B ALG10B ALG10	4.78e-05	46	31	3	int:KCNH2
Interaction	ABCA5 interactions	ABCA13 CDK7	4.79e-05	7	31	2	int:ABCA5
Interaction	CABLES1 interactions	TOP3B CDK3 CDK7	6.15e-05	50	31	3	int:CABLES1
Interaction	CDKN1B interactions	WWP1 CDK2 CDK3 CDK7	6.77e-05	144	31	4	int:CDKN1B
Interaction	ANKRD13D interactions	NID2 TOP3B MARCHF2	1.12e-04	61	31	3	int:ANKRD13D
GeneFamily	Alpha-1,2-glucosyltransferases	ALG10B ALG10	1.84e-06	2	25	2	448
GeneFamily	Cyclin dependent kinases	CDK2 CDK3 CDK7	5.95e-06	26	25	3	496
GeneFamily	Rhomboid family	RHBDD2 RHBDF2	1.65e-04	14	25	2	926
GeneFamily	Proteases, serine	PRSS41 TMPRSS11D	3.40e-03	63	25	2	738
Coexpression	MATZUK_MEIOTIC_AND_DNA_REPAIR	ATM TOP3B CDK2	1.61e-05	39	33	3	M1819
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UGT8 DPP10 ABCA13 TMPRSS11D	6.11e-06	162	33	4	bf886e22ff2a20353499004b53f25fb9e6574896
Computational	Transcription.	CDK2 CDK3 CDK7	3.55e-04	96	16	3	MODULE_124
Computational	Genes in the cancer module 303.	CDK2 CDK3	7.68e-04	28	16	2	MODULE_303
Drug	UCN-01	ATM TOP3B CDK2 CDK3 CDK7	2.70e-06	154	33	5	CID000072271
Drug	CDK1 inhibitor III	CDK2 CDK7	6.11e-06	3	33	2	CID000403994
Drug	AC1L9JJ0	UGT8 ATM CDK7	1.47e-05	33	33	3	CID000446336
Drug	olomoucine II	CDK2 CDK7	4.26e-05	7	33	2	ctd:C475587
Drug	Flavopiridol	CDK2 CDK7	9.10e-05	10	33	2	DB03496
Drug	imidazo(1,2-a)pyridine	CDK2 CDK7	9.10e-05	10	33	2	CID000078960
Drug	liposomal doxorubicin	ATM CDK2	1.33e-04	12	33	2	ctd:C506643
Drug	NSC105327	CDK2 CDK3 CDK7	1.42e-04	70	33	3	CID005318433
Drug	Nutlin	ATM CDK2 CDK7	1.48e-04	71	33	3	CID000216345
Drug	riccardin D	ATM CDK2 CDK7	1.81e-04	76	33	3	ctd:C547185
Drug	Fenspiride hydrochloride [5053-08-7]; Down 200; 13.4uM; MCF7; HT_HG-U133A	ATM RHBDF2 TOP3B CDK3	1.83e-04	197	33	4	2269_DN
Drug	7-benzylamino-5-(2-(hydroxymethyl)propyl)amino-3-isopropyl-1(2)H-pyrazolo(4,3-d)pyrimidine	CDK2 CDK7	1.83e-04	14	33	2	ctd:C559145
Drug	AC1L9FYY	CDK2 CDK7	1.83e-04	14	33	2	CID000444231
Drug	Carcinine [56897-53-1]; Down 200; 22uM; HL60; HT_HG-U133A	PITPNM1 PIGK CDK2 CDK3	1.90e-04	199	33	4	1305_DN
Drug	protoberberine	TOP3B TMPRSS11D	2.11e-04	15	33	2	CID000114943
Drug	AC1NDK7X	CDK2 CDK3 CDK7	2.71e-04	87	33	3	CID004627201
Drug	P-15	GLRA1 CDK2 CDK3 CDK7	2.88e-04	222	33	4	CID000200884
Drug	NSC683246	CDK2 CDK3 CDK7 TMPRSS11D	3.52e-04	234	33	4	CID000005097
Drug	Carbamates	ATM CDK2	4.20e-04	21	33	2	ctd:D002219
Drug	chromium-4	TTL UGT8	4.20e-04	21	33	2	CID000024808
Drug	diminazene	TOP3B TMPRSS11D	5.51e-04	24	33	2	CID000002354
Drug	AC1MPJID	UGT8 ATM TOP3B	6.45e-04	117	33	3	CID003386230
Drug	4',6-diamidino-2-phenylindole	TTL TOP3B TMPRSS11D	6.61e-04	118	33	3	CID000002954
Drug	olomoucine II	CDK2 CDK7	6.99e-04	27	33	2	CID005494414
Drug	2,3,5-trichloro-6-phenyl-(1,4)benzoquinone	ATM CDK2	7.52e-04	28	33	2	ctd:C587734
Drug	BN52020	TTL GLRA1	7.52e-04	28	33	2	CID000115221
Drug	butyrolactone I	CDK2 CDK3 CDK7	8.37e-04	128	33	3	CID000123740
Drug	bilobalide	TTL GLRA1	8.64e-04	30	33	2	CID000073581
Drug	olomoucine	CDK2 CDK3 CDK7	9.15e-04	132	33	3	CID000004592
Drug	variolin B	CDK2 CDK7	9.23e-04	31	33	2	CID009817550
Drug	isosilybin B	ATM CDK2	9.83e-04	32	33	2	CID003085830
Drug	cytidine 5'-diphosphocholine	PITPNM1 SGMS1 CDK2	1.06e-03	139	33	3	CID000000291
Drug	oxindole	CDK2 CDK7	1.11e-03	34	33	2	CID000321710
Drug	N6-9	CDK2 CDK7	1.11e-03	34	33	2	CID009547890
Drug	alsterpaullone	ATM CDK2	1.18e-03	35	33	2	CID005005498
Drug	taxol	TTL ATM TOP3B CDK2 CDK3	1.19e-03	560	33	5	CID000004666
Drug	[[(4aS,5aR,9aR)-2-amino-6,7-dimercapto-4-oxo-1,2,3,4a,5,5a,6,9a-octahydropyrano[3,2-g]pteridin-8-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(2-amino-6-oxo-7,8-dihydro-3H-purin-9-yl)-3,4-dihydroxy-2-oxolanyl]methyl hydrogen phosphate	ATM SGMS1	1.31e-03	37	33	2	CID005326617
Drug	aza-C-nucleosides	ATM TMPRSS11D	1.39e-03	38	33	2	CID000001336
Disease	Long Qt Syndrome 2	ALG10B ALG10	3.20e-06	3	31	2	C3150943
Disease	nonsyndromic deafness (implicated_via_orthology)	ALG10B ALG10	1.60e-05	6	31	2	DOID:0050563 (implicated_via_orthology)
Disease	circadian rhythm	TMEM151A PIGK ALG10B	6.64e-04	163	31	3	EFO_0004354
Disease	gut microbiome measurement, taxonomic microbiome measurement	XKR4 ABCA13	2.20e-03	66	31	2	EFO_0007874, EFO_0007883
Disease	cancer (implicated_via_orthology)	ATM CDK2 CDK3	2.76e-03	268	31	3	DOID:162 (implicated_via_orthology)
Disease	leptin measurement	ALG10B ALG10	3.29e-03	81	31	2	EFO_0005000
Disease	Glioblastoma Multiforme	CDK2 CDK3	6.07e-03	111	31	2	C1621958

Protein segments in the cluster

Peptide	Gene	Start	Entry
YAQKRSRYIYVVWVL	ACER1	51	Q8TDN7
YLVHAVSWLRVYQQV	ABCA13	341	Q86UQ4
NRHYTFYVWKRVFQR	ALG10B	351	Q5I7T1
SYVIYNIHTREVWEL	DPP10	156	Q8N608
FTIYVLWTLVSFRYH	MARCHF2	186	Q9P0N8
LVYRVNSYWFITADH	HINT3	161	Q9NQE9
WFNYRHVANTLSVYR	PIGK	56	Q92643
VYTNISVYFHWIRRV	PRSS41	281	Q7RTY9
WSYRIHQNITYQVCR	NID2	696	Q14112
LRTYTHEVVTLWYRA	CDK3	156	Q00526
WAFVLRDVIYTLIHY	ATM	1461	Q13315
NRAYTHQVVTRWYRA	CDK7	166	P50613
VNRTIYWIDYIIRHN	UGT8	441	Q16880
AVIVIQTYYRQWHAK	IQUB	341	Q8NA54
VRTYTHEVVTLWYRA	CDK2	156	P24941
RYFVTVWLRHYNPEV	MROH2A	261	A6NES4
YSVEVRITAYNVWAV	TAS2R30	76	P59541
FYWIIYKIVRREDVH	GLRA1	441	P23415
WKATSYHYVRRTRQI	TMEM151A	151	Q8N4L1
NRHYTFYVWKRVFQR	ALG10	351	Q5BKT4
VVRHWQDSGYLIVYV	PITPNM1	1051	O00562
VYTRVTAYLDWIRQQ	TMPRSS11D	401	O60235
WRLYEYITRHFIATV	TOP3B	406	O95985
RNWQVYRLVTYIFVY	RHBDD2	56	Q6NTF9
IRYFQRQTSFWRVYQ	TTC41P	706	Q6P2S7
QIWRYFHTIYLGIRS	XKR4	266	Q5GH76
VDVVVAYYITTRLFW	SGMS1	331	Q86VZ5
FYKRDQLIWSVVRHY	VPS13C	3391	Q709C8
HVTIRDYGVSWYQQR	VPREB3	46	Q9UKI3
RVYYVDHNTRTTTWQ	WWP1	396	Q9H0M0
TVYRHYTRNSKQIIW	WWP1	816	Q9H0M0
RPYFTYWLTFVHVII	RHBDF2	401	Q6PJF5
IRSWVLVDHQYNIYL	TTL	201	Q8NG68
VLTIAVRIYHDRWGY	MYMK	101	A6NI61