Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	diacylglycerol-dependent serine/threonine kinase activity	PRKD3 SMG1 PRKD1	7.14e-06	16	48	3	GO:0004697
HumanPheno	Reduced circulating CH50 activity	SERPING1 C5	3.46e-05	5	10	2	HP:0025434
HumanPheno	Abnormal total hemolytic complement activity	SERPING1 C5	3.46e-05	5	10	2	HP:0031904
Domain	Protein_Kinase_C_mu-related	PRKD3 PRKD1	1.86e-05	3	47	2	IPR015727
Domain	A2M_N_2	CD109 C5	1.72e-04	8	47	2	SM01359
Domain	-	CD109 C5	1.72e-04	8	47	2	2.60.40.690
Domain	A2M_recep	CD109 C5	1.72e-04	8	47	2	SM01361
Domain	A2M	CD109 C5	1.72e-04	8	47	2	SM01360
Domain	A2M_N	CD109 C5	2.75e-04	10	47	2	PF01835
Domain	A2M_N	CD109 C5	2.75e-04	10	47	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	CD109 C5	2.75e-04	10	47	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	CD109 C5	2.75e-04	10	47	2	PS00477
Domain	A2M	CD109 C5	2.75e-04	10	47	2	PF00207
Domain	A2M_N_2	CD109 C5	2.75e-04	10	47	2	IPR011625
Domain	A2M_comp	CD109 C5	2.75e-04	10	47	2	IPR011626
Domain	A2M_N_2	CD109 C5	2.75e-04	10	47	2	PF07703
Domain	A2M_recep	CD109 C5	2.75e-04	10	47	2	PF07677
Domain	A2M_comp	CD109 C5	2.75e-04	10	47	2	PF07678
Domain	Macroglobln_a2	CD109 C5	2.75e-04	10	47	2	IPR001599
Domain	-	CD109 C5	4.03e-04	12	47	2	1.50.10.20
Domain	Terpenoid_cyclase/PrenylTrfase	CD109 C5	9.24e-04	18	47	2	IPR008930
Domain	SH3_9	ARHGAP32 MAP3K9 RIMBP2	9.95e-04	78	47	3	PF14604
Domain	DAG/PE-bd	PRKD3 PRKD1	1.26e-03	21	47	2	IPR020454
Domain	GRAM	GRAMD1B NCOA7	1.39e-03	22	47	2	PF02893
Domain	GRAM	GRAMD1B NCOA7	1.39e-03	22	47	2	IPR004182
Domain	TUDOR	ARID4B KDM4C	2.09e-03	27	47	2	SM00333
Domain	Tudor	ARID4B KDM4C	2.58e-03	30	47	2	IPR002999
Domain	zf-C2H2	ZNF493 ZNF484 TSHZ2 KLF9 ZNF407 ZNF557	7.51e-03	693	47	6	PF00096
Domain	C1_1	PRKD3 PRKD1	9.06e-03	57	47	2	PF00130
Domain	RhoGAP	ARHGAP32 ARHGAP39	1.06e-02	62	47	2	SM00324
Domain	RhoGAP	ARHGAP32 ARHGAP39	1.10e-02	63	47	2	PF00620
Domain	ZF_DAG_PE_1	PRKD3 PRKD1	1.13e-02	64	47	2	PS00479
Domain	ZF_DAG_PE_2	PRKD3 PRKD1	1.13e-02	64	47	2	PS50081
Domain	RHOGAP	ARHGAP32 ARHGAP39	1.13e-02	64	47	2	PS50238
Domain	RhoGAP_dom	ARHGAP32 ARHGAP39	1.13e-02	64	47	2	IPR000198
Domain	-	ARHGAP32 ARHGAP39	1.13e-02	64	47	2	1.10.555.10
Domain	C1	PRKD3 PRKD1	1.17e-02	65	47	2	SM00109
Domain	PE/DAG-bd	PRKD3 PRKD1	1.20e-02	66	47	2	IPR002219
Domain	ZINC_FINGER_C2H2_2	ZNF493 ZNF484 TSHZ2 KLF9 ZNF407 ZNF557	1.26e-02	775	47	6	PS50157
Domain	ZINC_FINGER_C2H2_1	ZNF493 ZNF484 TSHZ2 KLF9 ZNF407 ZNF557	1.28e-02	777	47	6	PS00028
Pubmed	The deubiquitinating enzyme USP24 is a regulator of the UV damage response.	USP24 TP53	2.03e-06	2	50	2	25578727
Pubmed	Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression.	KLF9 TP53	2.03e-06	2	50	2	25242357
Pubmed	Complement Gene Expression Correlates with Superior Frontal Cortical Thickness in Humans.	SERPING1 C5	2.03e-06	2	50	2	28758643
Pubmed	Functional and therapeutic significance of protein kinase D enzymes in invasive breast cancer.	PRKD3 PRKD1	6.07e-06	3	50	2	26253275
Pubmed	A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY.	PRKD3 PRKD1	6.07e-06	3	50	2	27662904
Pubmed	A role for PKD1 and PKD3 activation in modulation of calcium oscillations induced by orexin receptor 1 stimulation.	PRKD3 PRKD1	6.07e-06	3	50	2	20621130
Pubmed	CD109 regulates in vivo tumor invasion in lung adenocarcinoma through TGF-β signaling.	CD109 TP53	6.07e-06	3	50	2	33007133
Pubmed	Effect of deletion of the protein kinase PRKD1 on development of the mouse embryonic heart.	PRKD3 PRKD1	6.07e-06	3	50	2	38419169
Pubmed	Expression of the protein kinase D (PKD) family during mouse embryogenesis.	PRKD3 PRKD1	6.07e-06	3	50	2	16377259
Pubmed	Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.	PRKD3 PRKD1	6.07e-06	3	50	2	32747433
Pubmed	Lack of PRKD2 and PRKD3 kinase domain somatic mutations in PRKD1 wild-type classic polymorphous low-grade adenocarcinomas of the salivary gland.	PRKD3 PRKD1	6.07e-06	3	50	2	26426580
Pubmed	Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers.	SMG1 TP53	6.07e-06	3	50	2	28288992
Pubmed	Gain of function mutant p53 proteins cooperate with E2F4 to transcriptionally downregulate RAD17 and BRCA1 gene expression.	TP53 RAD17	1.21e-05	4	50	2	25650659
Pubmed	Histone demethylase KDM4C controls tumorigenesis of glioblastoma by epigenetically regulating p53 and c-Myc.	KDM4C TP53	1.21e-05	4	50	2	33462212
Pubmed	microRNA-216b enhances cisplatin-induced apoptosis in osteosarcoma MG63 and SaOS-2 cells by binding to JMJD2C and regulating the HIF1α/HES1 signaling axis.	KDM4C HES1	1.21e-05	4	50	2	32972441
Pubmed	Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis.	HES1 TP53	1.21e-05	4	50	2	30705405
Pubmed	The PRKD1 promoter is a target of the KRas-NF-κB pathway in pancreatic cancer.	PRKD1 TP53	1.21e-05	4	50	2	27649783
Pubmed	The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells.	SMG1 TP53	1.21e-05	4	50	2	15175154
Pubmed	Protein kinase D regulates basolateral membrane protein exit from trans-Golgi network.	PRKD3 PRKD1	1.21e-05	4	50	2	14743217
Pubmed	Reprogramming fibroblasts to neural-precursor-like cells by structured overexpression of pallial patterning genes.	LHX2 TP53	1.21e-05	4	50	2	24128663
Pubmed	KDM4C-mediated senescence defense is a targetable vulnerability in gastric cancer harboring TP53 mutations.	KDM4C TP53	1.21e-05	4	50	2	37848946
Pubmed	The recombinant congenic strains--a novel genetic tool applied to the study of colon tumor development in the mouse.	C5 TP53 GSR	1.62e-05	34	50	3	1686571
Pubmed	Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma.	TSHZ2 SUMO1P1	2.02e-05	5	50	2	9671742
Pubmed	Important roles of Vilse in dendritic architecture and synaptic plasticity.	ARHGAP39 TP53	2.02e-05	5	50	2	28368047
Pubmed	HEY1 Leu94Met gene polymorphism dramatically modifies its biological functions.	HES1 TP53	2.02e-05	5	50	2	19802006
Pubmed	Protein kinase D regulates RhoA activity via rhotekin phosphorylation.	PRKD3 PRKD1	2.02e-05	5	50	2	22228765
Pubmed	G9a histone methyltransferase activity in retinal progenitors is essential for proper differentiation and survival of mouse retinal cells.	LHX2 HES1 TP53	2.10e-05	37	50	3	23223288
Pubmed	Genetic composition of the recombinant congenic strains.	C5 TP53 GSR	2.87e-05	41	50	3	8903730
Pubmed	Tff2 defines transit-amplifying pancreatic acinar progenitors that lack regenerative potential and are protective against Kras-driven carcinogenesis.	C5 TP53	3.03e-05	6	50	2	37541213
Pubmed	Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response.	C5 TP53	3.03e-05	6	50	2	18378907
Pubmed	Dlx1&2 and Mash1 transcription factors control striatal patterning and differentiation through parallel and overlapping pathways.	LHX2 TSHZ2 HES1 TP53	4.23e-05	134	50	4	19030180
Pubmed	Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis.	CD109 TP53	4.23e-05	7	50	2	28191885
Pubmed	A Glial Signature and Wnt7 Signaling Regulate Glioma-Vascular Interactions and Tumor Microenvironment.	C5 TP53	5.64e-05	8	50	2	29681511
Pubmed	Twist1 Activation in Muscle Progenitor Cells Causes Muscle Loss Akin to Cancer Cachexia.	C5 TP53	5.64e-05	8	50	2	29920276
Pubmed	Zinc finger protein gene complexes on mouse chromosomes 8 and 11.	TP53 GSR	7.25e-05	9	50	2	1981050
Pubmed	Basal cell carcinoma preferentially arises from stem cells within hair follicle and mechanosensory niches.	HES1 TP53	7.25e-05	9	50	2	25842978
Pubmed	Single cell enhancer activity distinguishes GABAergic and cholinergic lineages in embryonic mouse basal ganglia.	LHX2 TSHZ2 HES1	7.74e-05	57	50	3	35377797
Pubmed	Intratumoural heterogeneity generated by Notch signalling promotes small-cell lung cancer.	HES1 TP53	9.05e-05	10	50	2	28489825
Pubmed	Tel2 regulates the stability of PI3K-related protein kinases.	SMG1 TP53	9.05e-05	10	50	2	18160036
Pubmed	Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C.	PRKD3 PRKD1	1.10e-04	11	50	2	2182321
Pubmed	Potential role of Notch1 signaling pathway in laryngeal squamous cell carcinoma cell line Hep-2 involving proliferation inhibition, cell cycle arrest, cell apoptosis, and cell migration.	HES1 TP53	1.10e-04	11	50	2	19724860
Pubmed	Zeb2 regulates the balance between retinal interneurons and Müller glia by inhibition of BMP-Smad signaling.	LHX2 HES1	1.10e-04	11	50	2	32950463
Pubmed	In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46.	PRKD3 PRKD1	1.10e-04	11	50	2	8914829
Pubmed	Lhx2 balances progenitor maintenance with neurogenic output and promotes competence state progression in the developing retina.	LHX2 HES1	1.32e-04	12	50	2	23884928
Pubmed	HIV-1 Tat protein induces interleukin-10 in human peripheral blood monocytes: involvement of protein kinase C-betaII and -delta.	PRKD3 PRKD1	1.32e-04	12	50	2	11919157
Pubmed	Lhx2 is a progenitor-intrinsic modulator of Sonic Hedgehog signaling during early retinal neurogenesis.	LHX2 HES1	1.32e-04	12	50	2	36459481
Pubmed	Yes-associated protein (YAP) transcriptional coactivator functions in balancing growth and differentiation in skin.	LHX2 HES1	1.32e-04	12	50	2	21262812
Pubmed	The exon junction complex component EIF4A3 is essential for mouse and human cortical progenitor mitosis and neurogenesis.	LHX2 TP53	1.32e-04	12	50	2	37139782
Pubmed	Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a).	TP53 RAD17	1.32e-04	12	50	2	15149599
Pubmed	Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.	GRAMD1B SMG1 ARHGAP32 ARID4B ABCA13 GOLGA4	1.37e-04	552	50	6	10737800
Pubmed	Mash1 and Ngn1 control distinct steps of determination and differentiation in the olfactory sensory neuron lineage.	LHX2 HES1	1.56e-04	13	50	2	11934853
Pubmed	Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis.	LHX2 TP53	1.56e-04	13	50	2	36198802
Pubmed	Progressive effects of N-myc deficiency on proliferation, neurogenesis, and morphogenesis in the olfactory epithelium.	LHX2 HES1	1.82e-04	14	50	2	24376126
Pubmed	Cell-autonomous involvement of Mab21l1 is essential for lens placode development.	LHX2 HES1	1.82e-04	14	50	2	12642482
Pubmed	Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes.	PRKD3 PRKD1	2.10e-04	15	50	2	8627654
Pubmed	Role for Lhx2 in corticogenesis through regulation of progenitor differentiation.	LHX2 HES1	2.10e-04	15	50	2	23454273
Pubmed	Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome.	PRKD1 TP53	2.10e-04	15	50	2	12628923
Pubmed	Docking motif-guided mapping of the interactome of protein phosphatase-1.	DDX31 UBN1 RIMBP2	2.12e-04	80	50	3	19389623
Pubmed	Candidate gene association study of esophageal squamous cell carcinoma in a high-risk region in Iran.	GTDC1 TP53	2.40e-04	16	50	2	19826048
Pubmed	[HIV-1 Tat protein induces IL-10 production by human monocytes: implications of the PKC and calcium pathway].	PRKD3 PRKD1	2.40e-04	16	50	2	11833470
Pubmed	A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs.	HES1 TP53	2.40e-04	16	50	2	35577801
Pubmed	Mouse thalamic differentiation: gli-dependent pattern and gli-independent prepattern.	LHX2 HES1	2.40e-04	16	50	2	22371696
Pubmed	Inhibition of USP1 reverses the chemotherapy resistance through destabilization of MAX in the relapsed/refractory B-cell lymphoma.	AP3D1 TP53	2.72e-04	17	50	2	36352191
Pubmed	Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.	SMG1 TP53	2.72e-04	17	50	2	10428027
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SMG1 ARHGAP32 ARID4B LRRC37A3 USP24 C5	2.98e-04	638	50	6	31182584
Pubmed	A novel role for cardiac ankyrin repeat protein Ankrd1/CARP as a co-activator of the p53 tumor suppressor protein.	LHX2 TP53	3.05e-04	18	50	2	20599664
Pubmed	Specific mesenchymal/epithelial induction of olfactory receptor, vomeronasal, and gonadotropin-releasing hormone (GnRH) neurons.	LHX2 HES1	3.05e-04	18	50	2	20503368
Pubmed	m6A RNA methylation impacts fate choices during skin morphogenesis.	LHX2 HES1	3.05e-04	18	50	2	32845239
Pubmed	Foxf1 haploinsufficiency reduces Notch-2 signaling during mouse lung development.	HES1 TP53	3.05e-04	18	50	2	14607778
Pubmed	The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells.	HES1 TP53	3.05e-04	18	50	2	26598619
Pubmed	Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.	LHX2 TP53	3.05e-04	18	50	2	24982158
Pubmed	Six1 is indispensable for production of functional progenitor cells during olfactory epithelial development.	LHX2 HES1	3.41e-04	19	50	2	21302255
Pubmed	Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling.	LHX2 HES1	3.41e-04	19	50	2	26911688
Pubmed	The histone H3K36 demethylase Fbxl11 plays pivotal roles in the development of retinal late-born cell types.	LHX2 HES1	3.79e-04	20	50	2	37073980
Pubmed	Tat protein of human immunodeficiency virus type 1 induces interleukin-10 in human peripheral blood monocytes: implication of protein kinase C-dependent pathway.	PRKD3 PRKD1	3.79e-04	20	50	2	11044099
Pubmed	Cux2 functions downstream of Notch signaling to regulate dorsal interneuron formation in the spinal cord.	LHX2 HES1	3.79e-04	20	50	2	19542352
Pubmed	A series of recombinant inbred strains between the BALB/cHeA and STS/A mouse strains.	C5 GSR	4.18e-04	21	50	2	4042679
Pubmed	Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells.	PRKD3 PRKD1	4.18e-04	21	50	2	9446795
Pubmed	Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways.	PRKD3 PRKD1	4.18e-04	21	50	2	9671211
Pubmed	HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes.	PRKD3 PRKD1	4.59e-04	22	50	2	11154208
Pubmed	Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation.	LHX2 HES1	4.59e-04	22	50	2	15496443
Pubmed	Six1 is essential for early neurogenesis in the development of olfactory epithelium.	LHX2 HES1	5.48e-04	24	50	2	17880938
Pubmed	Disruption of GMNC-MCIDAS multiciliogenesis program is critical in choroid plexus carcinoma development.	HES1 TP53	5.48e-04	24	50	2	35322202
Pubmed	Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice.	PRKD3 C5	5.48e-04	24	50	2	19706712
Pubmed	Prox1 is required for granule cell maturation and intermediate progenitor maintenance during brain neurogenesis.	LHX2 HES1	5.48e-04	24	50	2	20808958
Pubmed	Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages.	PRKD3 PRKD1	5.48e-04	24	50	2	10843712
Pubmed	Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool.	DCHS2 HES1	5.48e-04	24	50	2	26116661
Pubmed	Substrate specificities and identification of putative substrates of ATM kinase family members.	TP53 RAD17	5.95e-04	25	50	2	10608806
Pubmed	Symmetric neural progenitor divisions require chromatin-mediated homologous recombination DNA repair by Ino80.	LHX2 TP53	5.95e-04	25	50	2	32737294
Pubmed	BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny.	LHX2 TP53	5.95e-04	25	50	2	23271346
Pubmed	Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer.	PRKD3 KYAT3 FAM98B	6.32e-04	116	50	3	30652415
Pubmed	The stage-dependent roles of Ldb1 and functional redundancy with Ldb2 in mammalian retinogenesis.	LHX2 HES1	6.44e-04	26	50	2	27697904
Pubmed	Modulation of the notch signaling by Mash1 and Dlx1/2 regulates sequential specification and differentiation of progenitor cell types in the subcortical telencephalon.	LHX2 HES1	6.44e-04	26	50	2	12397111
Pubmed	Global gene expression analysis of murine limb development.	LHX2 TSHZ2 TP53	6.48e-04	117	50	3	22174793
Pubmed	Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation.	LHX2 HES1	6.95e-04	27	50	2	24148613
Pubmed	Temporal analysis of enhancers during mouse cerebellar development reveals dynamic and novel regulatory functions.	LHX2 TP53	7.48e-04	28	50	2	35942939
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	LNPEP VPS45 AP3D1 GOLGA4	7.56e-04	285	50	4	34369648
Pubmed	Lhx2 links the intrinsic and extrinsic factors that control optic cup formation.	LHX2 HES1	8.02e-04	29	50	2	19906857
Pubmed	Chromatin Remodeling Enzyme Snf2h Is Essential for Retinal Cell Proliferation and Photoreceptor Maintenance.	LHX2 TP53	8.59e-04	30	50	2	37048108
Pubmed	Dlx1&2 and Mash1 transcription factors control MGE and CGE patterning and differentiation through parallel and overlapping pathways.	LHX2 TSHZ2 HES1	8.80e-04	130	50	3	19386638
Cytoband	20q13.2	TSHZ2 SUMO1P1	4.01e-04	27	50	2	20q13.2
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	CD109 C5	1.02e-04	9	31	2	1234
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZNF493 ZNF484 TSHZ2 KLF9 ZNF407 ZNF557	1.21e-03	718	31	6	28
GeneFamily	Rho GTPase activating proteins\|BCH domain containing	ARHGAP32 ARHGAP39	3.31e-03	50	31	2	721
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	DDX31 UBN1 RIMBP2	3.61e-03	181	31	3	694
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 ARID4B TSHZ2 KDM4C LNPEP USP24 GOLGA4	2.36e-09	197	50	7	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMG1 ARID4B LNPEP USP24 ZNF407	2.20e-06	188	50	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 TSHZ2 KDM4C LNPEP USP24	2.50e-06	193	50	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 LRRC37A3 KDM4C ZNF407 PRKD1	2.83e-06	198	50	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	control-Myeloid-pDC\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	GRAMD1B CCDC168 RAD17 ZNF557	3.78e-05	168	50	4	affc39c7568b7df4b36af6f5b0e3702a18b6268c
ToppCell	Thalamus-Neuronal-Excitatory\|Thalamus / BrainAtlas - Mouse McCarroll V32	LHX2 ARHGAP32 RIMBP2 ANKRD45	4.53e-05	176	50	4	d2bbf13d21fb7582d7e5f90cd61a4ebe1cfccd66
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-multi-ciliated_epithelial_cell-Multiciliated_(nasal)-Multiciliated_(nasal)_L.0.3.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP92 GAS2L2 ABCA13 ARHGAP39	4.73e-05	178	50	4	3b12db04006db6e94fc45649a4b3a63b92f21a61
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.5\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SMG1 ARHGAP32 TSHZ2 ABCA13	4.84e-05	179	50	4	6e965e424eebef50f0202cff75f458be395cfca1
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ2 ABCA13 SERPING1 PRKD1	5.61e-05	186	50	4	3dae539cce15fcf2b1b32e981d7febe94c03c600
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TSHZ2 ABCA13 SERPING1 HES1	5.73e-05	187	50	4	9225caf66e06ebe57e90d677122acb6498607f36
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	ABCA13 NCOA7 PRKD1 C5	5.85e-05	188	50	4	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	renal_cortex_nuclei-Adult_normal_reference\|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	GRAMD1B KLF9 RIMBP2 GOLGA4	5.97e-05	189	50	4	a48df46274d51e84ffb40264646de7346104efb9
ToppCell	Posterior_cortex-Neuronal\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	GAL3ST3 MAP3K9 NCOA7 ANKRD45	6.48e-05	193	50	4	b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCell	moderate-Myeloid-Monocyte-derived_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DCHS2 SERPING1 NCOA7 GOLGA4	6.48e-05	193	50	4	22455801194bd8c73c5c397f5eac4f723429c383
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	LRRC37A3 KDM4C ZNF407 PRKD1	6.88e-05	196	50	4	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	NS-moderate-d_07-13-Epithelial-Secretory\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TSHZ2 ABCA13 HES1 GSR	6.88e-05	196	50	4	47930de6b47b7bf22d8dae8b7419a9cd1d22f0ea
ToppCell	3'-Broncho-tracheal\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TSHZ2 ABCA13 NCOA7 HES1	7.01e-05	197	50	4	5d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SMG1 ARID4B SERPING1 GOLGA4	7.01e-05	197	50	4	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	Bronchial_Brush-Epithelial\|Bronchial_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	TSHZ2 ABCA13 NCOA7 HES1	7.01e-05	197	50	4	272c7f4e582ef57564450540242b0db766b78328
ToppCell	3'-Broncho-tracheal-Epithelial\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	TSHZ2 ABCA13 NCOA7 HES1	7.15e-05	198	50	4	aa6e7218ee6230902854e66c444b544218b30c0e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SMG1 ARID4B SERPING1 GOLGA4	7.15e-05	198	50	4	44417089b62056269cac38d3134ff209c05b7007
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SMG1 ARID4B SERPING1 GOLGA4	7.15e-05	198	50	4	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ARHGAP32 TSHZ2 ABCA13 GSR	7.15e-05	198	50	4	d0ecace1fad24ce50b0935036fabb07e6c9e372d
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 USP24 ZNF407 GOLGA4	7.29e-05	199	50	4	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP32 LRRC37A3 KDM4C ZNF407	7.29e-05	199	50	4	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	(04)_Interm._basal>secr.-(2)_GFP_FOXI1\|(04)_Interm._basal>secr. / shred by cell type by condition	ARID4B KLF9 NCOA7 GOLGA4	7.29e-05	199	50	4	53ca3861f9e00dab3f3fbefb0837857ee39ab084
ToppCell	(09)_Interm._secr.>cil.-(2)_GFP_FOXI1\|(09)_Interm._secr.>cil. / shred by cell type by condition	ARID4B KLF9 AP3D1 GOLGA4	7.29e-05	199	50	4	fc680f85ebd3bab4c72876a19a461b0afb5f51ce
ToppCell	Tracheal-10x3prime_v2-Stromal-Peri/Epineurial_\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	KLF9 SERPING1 ZNF407 CCDC7	7.44e-05	200	50	4	f7c3a8f5ac156c05ad7335d6d142c154c7d86449
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 ARID4B SERPING1 GOLGA4	7.44e-05	200	50	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Disease	medulloblastoma (is_marker_for)	KDM4C TP53	2.80e-05	5	50	2	DOID:0050902 (is_marker_for)
Disease	glioblastoma (implicated_via_orthology)	SERPING1 TP53	1.01e-04	9	50	2	DOID:3068 (implicated_via_orthology)
Disease	gastric adenocarcinoma (is_implicated_in)	ABCA13 TP53	1.53e-04	11	50	2	DOID:3717 (is_implicated_in)
Disease	phosphoenolpyruvic acid measurement	KDM4C RIMBP2	2.91e-04	15	50	2	EFO_0010522
Disease	T-Cell Lymphoma	KDM4C TP53	3.33e-04	16	50	2	C0079772
Disease	response to paliperidone, schizophrenia symptom severity measurement	KLF9 VPS45 ADGRE3 USP24	4.94e-04	216	50	4	EFO_0007925, EFO_0007927
Disease	serum IgM measurement	GRAMD1B PRKD1	6.36e-04	22	50	2	EFO_0004993
Disease	macular degeneration (is_implicated_in)	SERPING1 GSR	9.61e-04	27	50	2	DOID:4448 (is_implicated_in)
Disease	Amyotrophic Lateral Sclerosis With Dementia	TP53 GSR	1.11e-03	29	50	2	C0393554
Disease	Colorectal Neoplasms	ABCA13 CD109 PRKD1 TP53	1.25e-03	277	50	4	C0009404
Disease	Amyotrophic Lateral Sclerosis, Guam Form	TP53 GSR	1.27e-03	31	50	2	C0543859
Disease	renal cell carcinoma (is_marker_for)	LNPEP TP53 GSR	1.35e-03	128	50	3	DOID:4450 (is_marker_for)
Disease	Complement deficiency disease	SERPING1 C5	1.44e-03	33	50	2	C0272242
Disease	Uterine Cervical Neoplasm	HES1 TP53	1.62e-03	35	50	2	C0007873
Disease	lymphoid leukemia	GRAMD1B TP53	1.90e-03	38	50	2	EFO_0004289
Disease	candidiasis (implicated_via_orthology)	PRKD3 PRKD1	2.54e-03	44	50	2	DOID:1508 (implicated_via_orthology)
Disease	esophagus squamous cell carcinoma (is_implicated_in)	KDM4C TP53	2.66e-03	45	50	2	DOID:3748 (is_implicated_in)
Disease	acute myeloid leukemia (is_marker_for)	TP53 GSR	3.15e-03	49	50	2	DOID:9119 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
SSEIHFKVKMTTPLK	SUMO1P1	31	G2XKQ0
KSQPVKSVSTGMKSH	ARID4B	1166	Q4LE39
MKPVKHLLTTSNKSA	CCDC7	1	Q96M83
SFTPMYHAVTKRKTK	GSR	446	P00390
IFTKMTTPCQVKSAK	ANKRD45	236	Q5TZF3
KVSGKMSTVFKTHFI	ABCA13	2531	Q86UQ4
KKHPKTDSSVTKMRR	CFAP92	101	Q9ULG3
MHRQSPKEKASKTTT	GRAMD1B	546	Q3KR37
AMSKILKTHPKSVQS	AP3D1	326	O14617
MSKTFLRPKVSSTKV	RAD17	1	O75943
SIKKPMIVTSDRHVK	ARHGAP39	726	Q9C0H5
TEFHPSMIKRSKKAL	KLF9	226	Q13886
TSKMKTLTRVQPVFH	C20orf96	51	Q9NUD7
KARVTNMKTSKPIVH	LRRC37A3	1286	O60309
QSVKHTKRKSSTVMK	PRKD1	411	Q15139
TKTMAKVITTVLKFP	GOLGA4	2191	Q13439
RHKMTLISPSVLKKY	KDM4C	241	Q9H3R0
SIKHTKRKSSTMVKE	PRKD3	406	O94806
FKTMKKDSLNSSHPI	LNPEP	516	Q9UIQ6
PSSQKTKRMRTSFKH	LHX2	261	P50458
LKLKEPHTMSRSQKF	GDPD1	236	Q8N9F7
STSRHKKLMFKTEGP	TP53	376	P04637
QKMFSPKKHSVSTSD	DDX31	176	Q9H8H2
TASMKVKHVKKLPFT	ARHGAP32	96	A7KAX9
MKIIAHSPKSDSKFA	DCHS2	2956	Q6V1P9
PKHMTVAFLKTHKTA	GAL3ST3	61	Q96A11
KSSMAVHSLFKSPSK	CD109	451	Q6YHK3
KASLSAKGTHMRKVP	GAS2L2	706	Q8NHY3
VVSKHFSKSKRMPIT	C5	106	P01031
ILSPYEHKSKISVKM	CCDC66	21	A2RUB6
KRYALSPKTTITMAH	FAM98B	256	Q52LJ0
KKTRMEPFHFKNSVI	SERPING1	306	P05155
PVLSCSKVMKKRVTF	CCDC168	1341	Q8NDH2
DVSRFMPKHKTTHLK	GTDC1	171	Q4AE62
MTKHKKLSAIPVSAF	KYAT3	401	Q6YP21
HKFTVQASPTMDKRK	MAP3K9	526	P80192
ASEHRKSSKPIMEKR	HES1	31	Q14469
TPMRSKAKRKKSVHF	RIMBP2	1036	O15034
VLPTTSEHTAKKMKA	UBOX5	391	O94941
IKVGKPMRKSFATHT	NCOA7	661	Q8NI08
PRSAILTSMKKKLHT	SMG1	3221	Q96Q15
KHMTRTIYTSPIKAL	SKIV2L	351	Q15477
QHVKMTPSTKKVFCV	ADGRE3	291	Q9BY15
FKKMSGTVSKHVTVV	VPS45	321	Q9NRW7
TISSKMVTPAKKRVF	TSHZ2	311	Q9NRE2
KSPHFSAKMNSLKEV	USP24	396	Q9UPU5
HLTSILAKKKVMAPS	UBN1	581	Q9NPG3
KAFKRSSTLTIHKMI	ZNF493	396	Q6ZR52
KAFTRKSTLSMHQKI	ZNF484	391	Q5JVG2
KKSRTMATKNVHSKP	ZNF407	291	Q9C0G0
MATKNVHSKPRTSKS	ZNF407	296	Q9C0G0
KSFNVLSSVKKHMRT	ZNF557	376	Q8N988
HPSKKMQTKISLSTL	THEGL	321	P0DJG4