Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	REEP5 ATP2A2 ITPR2	4.86e-05	45	33	3	GO:0033017
GeneOntologyCellularComponent	platelet dense tubular network membrane	ATP2A2 ITPR2	8.64e-05	9	33	2	GO:0031095
GeneOntologyCellularComponent	platelet dense tubular network	ATP2A2 ITPR2	1.32e-04	11	33	2	GO:0031094
GeneOntologyCellularComponent	sarcoplasmic reticulum	REEP5 ATP2A2 ITPR2	3.59e-04	88	33	3	GO:0016529
GeneOntologyCellularComponent	sarcoplasm	REEP5 ATP2A2 ITPR2	7.65e-04	114	33	3	GO:0016528
Domain	TCEAL1	TCEAL6 TCEAL3 TCEAL5	3.81e-07	9	32	3	IPR010370
Domain	BEX	TCEAL6 TCEAL3 TCEAL5	1.64e-06	14	32	3	PF04538
Domain	TF_A-like/BEX	TCEAL6 TCEAL3 TCEAL5	1.64e-06	14	32	3	IPR021156
Domain	ARM-type_fold	ARMC9 PSME4 PIK3C2B RPTOR UBR4 ITPR2	2.08e-05	339	32	6	IPR016024
Domain	Ank	ASAP3 ANKRD62 ANKRD60 TONSL	5.95e-04	228	32	4	PF00023
Domain	-	ASAP3 ANKRD62 ANKRD60 TONSL	8.15e-04	248	32	4	1.25.40.20
Domain	ANK	ASAP3 ANKRD62 ANKRD60 TONSL	8.52e-04	251	32	4	SM00248
Domain	ANK_REPEAT	ASAP3 ANKRD62 ANKRD60 TONSL	8.77e-04	253	32	4	PS50088
Domain	Ankyrin_rpt-contain_dom	ASAP3 ANKRD62 ANKRD60 TONSL	8.90e-04	254	32	4	IPR020683
Domain	ANK_REP_REGION	ASAP3 ANKRD62 ANKRD60 TONSL	8.90e-04	254	32	4	PS50297
Domain	Ankyrin_rpt	ASAP3 ANKRD62 ANKRD60 TONSL	9.99e-04	262	32	4	IPR002110
Domain	Ubiquitin-rel_dom	PTPN13 PIK3C2B ANKRD60	3.78e-03	184	32	3	IPR029071
Domain	Ank_2	ASAP3 ANKRD60 TONSL	5.83e-03	215	32	3	PF12796
Domain	-	ARMC9 PSME4 RPTOR	6.37e-03	222	32	3	1.25.10.10
Domain	TYR_PHOSPHATASE_1	PTPN13 DUSP8	9.50e-03	86	32	2	PS00383
Domain	TYR_PHOSPHATASE_2	PTPN13 DUSP8	9.72e-03	87	32	2	PS50056
Domain	TYR_PHOSPHATASE_dom	PTPN13 DUSP8	9.72e-03	87	32	2	IPR000387
Domain	-	PTPN13 DUSP8	1.08e-02	92	32	2	3.90.190.10
Domain	ARM-like	ARMC9 PSME4 RPTOR	1.09e-02	270	32	3	IPR011989
Pubmed	Cell micropatterning reveals the modulatory effect of cell shape on proliferation through intracellular calcium transients.	ATP2A2 ITPR2	8.73e-07	2	33	2	28962833
Pubmed	Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events.	TCEAL6 TCEAL3 TCEAL5	1.55e-06	24	33	3	16221301
Pubmed	A 1.1-Mb segmental deletion on the X chromosome causes meiotic failure in male mice.	TCEAL6 TCEAL3 TCEAL5	2.51e-06	28	33	3	23677977
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ASAP3 ANKRD62 KLHL24 UBR4 TONSL ZNF304	2.88e-06	430	33	6	35044719
Pubmed	SERCA2b and 3 play a regulatory role in store-operated calcium entry in human platelets.	ATP2A2 ITPR2	5.23e-06	4	33	2	18068335
Pubmed	Comparative Host Interactomes of the SARS-CoV-2 Nonstructural Protein 3 and Human Coronavirus Homologs.	PTPN13 REEP5 ATP2A2 ABCB8 ITPR2	8.43e-06	296	33	5	34186245
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	ATP2A2 ITPR2	2.44e-05	8	33	2	19033399
Pubmed	Neuronal calcium sensor-1 promotes immature heart function and hypertrophy by enhancing Ca2+ signals.	ATP2A2 ITPR2	2.44e-05	8	33	2	21737792
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	SPATA20 PSME4 NUP85 PIK3C2B RPTOR UBR4 ITPR2	6.64e-05	1105	33	7	35748872
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	LRIG3 PTPN13 REEP5 RPTOR ITPR2	1.06e-04	504	33	5	34432599
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	NUP85 REEP5 ATP2A2 RPTOR MFN1 ABCB8 FAM20B	1.13e-04	1203	33	7	29180619
Pubmed	Calcium handling precedes cardiac differentiation to initiate the first heartbeat.	ATP2A2 ITPR2	1.18e-04	17	33	2	27725084
Pubmed	Targeting of EGFR by a combination of antibodies mediates unconventional EGFR trafficking and degradation.	PIK3C2B RPTOR	1.48e-04	19	33	2	31959764
Pubmed	Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions.	TCEAL3 TCEAL5	1.64e-04	20	33	2	33100228
Pubmed	The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation.	ATP2A2 MFN1	1.99e-04	22	33	2	28890335
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	ASAP3 PTPN13 PSME4 UBR4	2.39e-04	322	33	4	26514267
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	ATP2A2 TONSL ITPR2	3.90e-04	150	33	3	30154076
Pubmed	LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.	ATP2A2 ITPR2	4.81e-04	34	33	2	26378152
Pubmed	Cfp1 Controls Cardiomyocyte Maturation by Modifying Histone H3K4me3 of Structural, Metabolic, and Contractile Related Genes.	ATP2A2 MFN1	6.01e-04	38	33	2	38196272
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	ATP2A2 ITPR2	6.01e-04	38	33	2	30786075
Interaction	GPR17 interactions	ARMC9 ATP2A2 MFN1 ABCB8 TONSL ITPR2	3.99e-06	283	31	6	int:GPR17
Interaction	CHRM5 interactions	NPAS3 REEP5 ATP2A2	2.90e-05	39	31	3	int:CHRM5
Interaction	TCEAL3 interactions	TCEAL3 TCEAL5	3.42e-05	6	31	2	int:TCEAL3
Cytoband	12q14.1	LRIG3 ERVK-21	1.87e-04	28	33	2	12q14.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	TCEAL6 TCEAL3 TCEAL5	2.60e-04	172	33	3	chrXq22
Cytoband	Xq22.1	TCEAL6 TCEAL5	4.44e-04	43	33	2	Xq22.1
GeneFamily	Transcription elongation factor A like family	TCEAL6 TCEAL3 TCEAL5	2.48e-07	9	27	3	1216
GeneFamily	Ankyrin repeat domain containing	ASAP3 ANKRD62 ANKRD60 TONSL	4.31e-04	242	27	4	403
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TOR1B PIK3C2B RPTOR ABCB8	6.07e-06	167	32	4	774f3264318b002d0df5d06d41d645366038d0bf
ToppCell	TCGA-Uvea-Primary_Tumor-Uveal_Melanoma-Epithelioid_Cell\|TCGA-Uvea / Sample_Type by Project: Shred V9	ARMC9 TOR1B ATP2A2 ITPR2	9.29e-06	186	32	4	e8580a2093eb7e50aad55ec7fada850d2fed8ae1
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPAS3 ANKRD62 TCEAL6 TCEAL5	1.12e-05	195	32	4	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPAS3 ANKRD62 TCEAL6 TCEAL5	1.12e-05	195	32	4	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
Disease	white matter microstructure measurement	DPEP1 KLHL24 ARMC9 DCDC1	4.79e-04	390	28	4	EFO_0005674
Disease	obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia, anorexia nervosa	NPAS3 ATP2A2 RPTOR	8.87e-04	200	28	3	EFO_0003756, EFO_0003761, EFO_0003888, EFO_0004242, EFO_0004895, MONDO_0004985, MONDO_0005090, MONDO_0005351
Disease	mean arterial pressure	NDP DCDC1 ATP2A2 RPTOR	1.20e-03	499	28	4	EFO_0006340
Disease	QT interval	ASAP3 LRIG3 ATP2A2 ITPR2	1.54e-03	534	28	4	EFO_0004682
Disease	pulmonary hypertension (biomarker_via_orthology)	ATP2A2 MFN1	2.62e-03	80	28	2	DOID:6432 (biomarker_via_orthology)
Disease	Cardiac Hypertrophy	ATP2A2 ITPR2	2.75e-03	82	28	2	C1383860
Disease	Cardiomegaly	ATP2A2 ITPR2	2.75e-03	82	28	2	C0018800
Disease	diastolic blood pressure, systolic blood pressure	DPEP1 LRIG3 ARMC9 DCDC1	3.50e-03	670	28	4	EFO_0006335, EFO_0006336

Protein segments in the cluster

Peptide	Gene	Start	Entry
DMQRERRIFQLHMCE	ASAP3	181	Q8TDY4
RSCQMEFEEGMVEGR	DUSP8	586	Q13202
MFRVANCRGDMTVRE	ANKRD60	106	Q9BZ19
MEVRGSFLAACRRRM	ANKRD62	1	A6NC57
EVVSMKRMVHDGTRC	ADAMTS2	666	O95450
LHMMCSERDRGDESG	ITPR2	1356	Q14571
PEYMEDVRRQHMERC	MFN1	246	Q8IWA4
DDIERDMVICVSMGH	DCDC1	1721	M0R2J8
AARERRMHVMPEDDV	LRIG3	646	Q6UXM1
REEARAMGMEDILRC	ARMC9	536	Q7Z3E5
RSVIRACMEEMHQVA	NUP85	106	Q9BW27
DMRMVIFRCFSTGRG	PIK3C2B	1111	O00750
MSVCRMFILDRVEGD	ATP2A2	361	P16615
FRAMFCNDHRESREM	KLHL24	91	Q6TFL4
RRDSDHRERAMMTMV	ERVK-21	661	P61565
RRTLEQMDVVHRMCR	DPEP1	96	P16444
LSAERMRDIERHFGC	NLRP6	551	P59044
MRDIERHFGCMVSER	NLRP6	556	P59044
RCMRLQRHGMVQTED	PTPN13	2441	Q12923
LSHVGERMAVDMRRA	ABCB8	216	Q9NUT2
VRIDCHMFVTRVNMD	NPAS3	326	Q8IXF0
MSAAMRERFDRFLHE	REEP5	1	Q00765
RMALSECRVMTYREH	RPTOR	1196	Q8N122
EGARECAHTMRKRFM	TONSL	226	Q96HA7
RHMFDVASGRLMRTC	SPATA20	541	Q8TB22
EDQRAFHRMMTGLRV	FAM20B	36	O75063
ERHLSSEEMMRECGD	TCEAL6	131	Q6IPX3
QERHLSSEEMMRECG	TCEAL5	136	Q5H9L2
HIFETRVAGRMVADM	PSME4	616	Q14997
RVAGRMVADMCRAAV	PSME4	621	Q14997
ERHLSSEEMMRECGD	TCEAL3	131	Q969E4
IMDSDPRRCMRHHYV	NDP	31	Q00604
HMLGRSFTCREEGMD	ZNF304	161	Q9HCX3
RGAAAMREEVRQLMC	UBR4	3916	Q5T4S7
MCVRAEMRARGSAID	TOR1B	286	O14657