Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyBiologicalProcessestablishment of skin barrier

FLG HRNR FLG2

1.43e-0541243GO:0061436
GeneOntologyCellularComponentkeratohyalin granule

FLG HRNR FLG2

1.33e-085243GO:0036457
GeneOntologyCellularComponentcornified envelope

FLG HRNR FLG2

6.63e-0569243GO:0001533
GeneOntologyCellularComponentcollagen-containing extracellular matrix

FLG MXRA5 PLG HRNR COL17A1

2.93e-04530245GO:0062023
GeneOntologyCellularComponentextracellular matrix

FLG MXRA5 PLG HRNR COL17A1

7.76e-04656245GO:0031012
GeneOntologyCellularComponentexternal encapsulating structure

FLG MXRA5 PLG HRNR COL17A1

7.87e-04658245GO:0030312
DomainFilaggrin

FLG FLG2

1.58e-062242IPR003303
DomainS100_CABP

FLG HRNR FLG2

5.34e-0627243PS00303
DomainS_100

FLG HRNR FLG2

5.34e-0627243PF01023
DomainS100_Ca-bd_sub

FLG HRNR FLG2

5.98e-0628243IPR013787
DomainS100/CaBP-9k_CS

FLG HRNR FLG2

5.98e-0628243IPR001751
DomainS_100

FLG HRNR FLG2

5.98e-0628243SM01394
DomainZnf_CCCH

RC3H2 ZC3H18 ZC3HAV1

5.49e-0558243IPR000571
DomainZF_C3H1

RC3H2 ZC3H18 ZC3HAV1

5.49e-0558243PS50103
Domain-

RC3H2 ZC3H18

1.20e-03402424.10.1000.10
DomainEF_Hand_1_Ca_BS

FLG HRNR FLG2

1.42e-03175243IPR018247
DomainZnF_C3H1

RC3H2 ZC3H18

1.72e-0348242SM00356
Domainzf-CCCH

RC3H2 ZC3HAV1

1.79e-0349242PF00642
DomainEF_HAND_1

FLG HRNR FLG2

2.19e-03204243PS00018
DomainEF_HAND_2

FLG HRNR FLG2

3.12e-03231243PS50222
DomainEF_hand_dom

FLG HRNR FLG2

3.16e-03232243IPR002048
Domain-

FLG HRNR FLG2

4.39e-032612431.10.238.10
DomainEF-hand-dom_pair

FLG HRNR FLG2

5.72e-03287243IPR011992
DomainZnf_RING

MARCHF7 RC3H2 TRIM37

8.13e-03326243IPR001841
Pubmed

Defects of filaggrin-like proteins in both lesional and nonlesional atopic skin.

FLG HRNR FLG2

2.89e-10324323403047
Pubmed

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

FLG MXRA5 HRNR COL17A1

9.47e-086224428344315
Pubmed

Variation in genes of the epidermal differentiation complex in German atopic dermatitis patients.

FLG HRNR FLG2

3.81e-072124319601998
Pubmed

Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.

FLG HRNR

4.56e-07224227678121
Pubmed

Plasmin plays a role in the in vitro generation of the linear IgA dermatosis antigen LADB97.

PLG COL17A1

4.56e-07224219158842
Pubmed

Expression of filaggrin-2 protein in the epidermis of human skin diseases: a comparative analysis with filaggrin.

FLG FLG2

4.56e-07224224813994
Pubmed

Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop.

MISP SRSF8 HRNR SEC16A FLG2

8.50e-0726024536199071
Pubmed

GATA3 regulates FLG and FLG2 expression in human primary keratinocytes.

FLG FLG2

1.37e-06324228928464
Pubmed

Filaggrin and filaggrin 2 processing are linked together through skin aspartic acid protease activation.

FLG FLG2

1.37e-06324232437351
Pubmed

Extracellular Hsp90α and clusterin synergistically promote breast cancer epithelial-to-mesenchymal transition and metastasis via LRP1.

PLG HRNR FLG2

3.75e-064424331273033
Pubmed

Expression of Cornified Envelope Proteins in Skin and Its Relationship with Atopic Dermatitis Phenotype.

FLG FLG2

6.83e-06624227304082
Pubmed

Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS.

PER1 ZC3H18 HRNR SEC16A FLG2

1.01e-0543224523455922
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

PPHLN1 MISP ZC3H18 HRNR COL17A1 ZC3HAV1 FLG2

1.60e-05125724736526897
Pubmed

DDX24 promotes metastasis by regulating RPL5 in non-small cell lung cancer.

FLG HRNR ZC3HAV1 FLG2

2.04e-0523824435864588
Pubmed

SARS-CoV-2 N Protein Antagonizes Stress Granule Assembly and IFN Production by Interacting with G3BPs to Facilitate Viral Replication.

FLG HRNR ZC3HAV1 FLG2

2.29e-0524524435652658
Pubmed

LncRNA SAMD12-AS1 promotes cell proliferation and inhibits apoptosis by interacting with NPM1.

FLG HRNR

3.00e-051224231406141
Pubmed

Identification of Smurf2 as a HIF-1α degrading E3 ubiquitin ligase.

MARCHF7 TRIM37

3.00e-051224234611473
Pubmed

ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.

FLG MISP ZC3HAV1 SEC16A

3.24e-0526824433024031
Pubmed

TRIM25 and DEAD-Box RNA Helicase DDX3X Cooperate to Regulate RIG-I-Mediated Antiviral Immunity.

FLG HRNR FLG2

3.37e-059124334445801
Pubmed

Human transcription factor protein interaction networks.

FLG TCF4 ZC3H18 HRNR ZC3HAV1 SEC16A FLG2

3.64e-05142924735140242
Pubmed

KAP1 Recruitment of the 7SK snRNP Complex to Promoters Enables Transcription Elongation by RNA Polymerase II.

FLG HRNR ZC3HAV1 FLG2

3.90e-0528124426725010
Pubmed

PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78.

FLG HRNR

4.13e-051424229178343
Pubmed

A Noncanonical Role of Fructose-1, 6-Bisphosphatase 1 Is Essential for Inhibition of Notch1 in Breast Cancer.

PLG HRNR ZC3HAV1 FLG2

4.18e-0528624432041737
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

FLG ZC3H18 HRNR ZC3HAV1 FLG2

5.06e-0560524528977666
Pubmed

TRIM30 modulates Interleukin-22-regulated papillary thyroid Cancer cell migration and invasion by targeting Sox17 for K48-linked Polyubiquitination.

HRNR FLG2

5.44e-051624231823782
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

FLG TRIM37 HRNR ZC3HAV1 SEC16A

6.56e-0563924523443559
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

PPHLN1 MISP ZC3H18 ZC3HAV1

1.03e-0436124430344098
Pubmed

RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.

PPHLN1 SRSF8 ZC3H18 NKTR ZC3HAV1

1.10e-0471324529802200
Pubmed

HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis.

FLG RC3H2 MISP HRNR SEC16A

1.43e-0475424535906200
Pubmed

Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.

MARCHF7 RC3H2 TRIM37

1.46e-0414924319549727
Pubmed

In Vitro Identification of Histatin 5 Salivary Complexes.

FLG HRNR

1.59e-042724226544073
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

PITPNM1 ZC3H18 CXADR ZC3HAV1 SEC16A

1.61e-0477424515302935
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

CXADR HRNR ZC3HAV1 SEC16A FLG2

1.64e-0477724535844135
Pubmed

A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.

UNC80 HRNR ZC3HAV1 SEC16A

1.84e-0442024428065597
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

CXADR ABI1 ZC3HAV1 SEC16A

1.86e-0442124436976175
Pubmed

Aerobic glycolysis tunes YAP/TAZ transcriptional activity.

HRNR SEC16A FLG2

1.87e-0416224325796446
Pubmed

The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.

RC3H2 PPHLN1 SRSF8 ZC3H18 ZC3HAV1

1.96e-0480724522681889
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

PPHLN1 MISP SRSF8 ZC3H18 NKTR ZC3HAV1

1.98e-04129424630804502
Pubmed

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.

RC3H2 PPHLN1 SRSF8 NKTR SEC16A FLG2

2.71e-04137124636244648
Pubmed

Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.

TRIM37 HRNR SEC16A

2.72e-0418424332908313
Pubmed

Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes.

FLG HRNR

2.83e-043624231669268
Pubmed

PINK1 Content in Mitochondria is Regulated by ER-Associated Degradation.

FLG MISP NKTR FLG2

2.99e-0447724431300519
Pubmed

AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis.

ABI1 HRNR ZC3HAV1

3.47e-0420024335546148
Pubmed

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.

TCF4 MISP ZC3H18 HRNR

3.65e-0450324436217030
Pubmed

Interactomes of Glycogen Synthase Kinase-3 Isoforms.

RC3H2 MISP SEC16A

3.94e-0420924336779422
Pubmed

A functional reference map of the RNF8 interactome in cancer.

FLG HRNR FLG2

4.46e-0421824335831895
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

HRNR ZC3HAV1 FLG2

5.48e-0423424336243803
Pubmed

Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.

MISP ZC3HAV1 SEC16A

5.55e-0423524328378594
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

PITPNM1 HRNR SEC16A FLG2

5.62e-0456424421565611
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

CXADR ABI1 COL17A1 ZC3HAV1

5.66e-0456524425468996
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

PER1 MARCHF7 TRIM37 ZC3HAV1 SEC16A

6.21e-04103824526673895
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

HRNR FLG2

6.39e-045424235474131
Pubmed

Analysis of HIV-1 Gag protein interactions via biotin ligase tagging.

HRNR ZC3HAV1

6.39e-045424225631074
Pubmed

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions.

FLG HRNR

6.87e-045624237059927
InteractionDSP interactions

RC3H2 TRIM37 ZC3H18 HRNR COL17A1 SEC16A FLG2

4.34e-07423247int:DSP
InteractionZNF816 interactions

TRIM37 ZC3H18 NKTR

8.23e-0716243int:ZNF816
InteractionNXF2 interactions

PER1 PPHLN1 SRSF8 ZC3HAV1

9.98e-0765244int:NXF2
InteractionDPRX interactions

HRNR SEC16A FLG2

1.20e-0618243int:DPRX
InteractionKIF23 interactions

FLG TRIM37 PPHLN1 MISP SRSF8 ZC3H18 HRNR ZC3HAV1 FLG2

1.51e-061031249int:KIF23
InteractionDSG1 interactions

FLG TRIM37 ZC3H18 HRNR FLG2

2.22e-06184245int:DSG1
InteractionANXA2 interactions

FLG TRIM37 MISP ZC3H18 PLG FLG2

7.63e-06419246int:ANXA2
InteractionHNRNPA1 interactions

FLG RC3H2 TRIM37 PPHLN1 ZC3H18 HRNR SEC16A FLG2

8.53e-06945248int:HNRNPA1
InteractionSNRPA interactions

RC3H2 PPHLN1 SRSF8 ZC3H18 NKTR ZC3HAV1

1.69e-05482246int:SNRPA
InteractionHNRNPUL2 interactions

RC3H2 PPHLN1 SRSF8 ZC3H18 SEC16A

2.06e-05291245int:HNRNPUL2
InteractionSRSF6 interactions

RC3H2 PPHLN1 SRSF8 ZC3H18 NKTR ZC3HAV1

2.15e-05503246int:SRSF6
InteractionPABPC5 interactions

RC3H2 PPHLN1 SRSF8 ZC3H18

2.25e-05142244int:PABPC5
InteractionSRSF4 interactions

RC3H2 SRSF8 ZC3H18 NKTR ZC3HAV1

2.38e-05300245int:SRSF4
InteractionSRSF3 interactions

RC3H2 TRIM37 PPHLN1 SRSF8 ZC3H18 ZC3HAV1

2.65e-05522246int:SRSF3
InteractionBCLAF1 interactions

PER1 RC3H2 PPHLN1 ZC3H18 ABI1

3.60e-05327245int:BCLAF1
InteractionCEP85 interactions

RC3H2 TRIM37 ZC3HAV1 SEC16A

4.45e-05169244int:CEP85
InteractionKLHL40 interactions

PER1 MARCHF7 PPHLN1

4.62e-0559243int:KLHL40
InteractionDDX24 interactions

FLG RC3H2 ZC3H18 HRNR ZC3HAV1 FLG2

5.57e-05596246int:DDX24
InteractionPPP1R16B interactions

MISP CXADR HRNR

6.18e-0565243int:PPP1R16B
InteractionKLF5 interactions

FLG HRNR SEC16A FLG2

7.76e-05195244int:KLF5
InteractionCLK2 interactions

PPHLN1 SRSF8 ZC3H18 NKTR

7.76e-05195244int:CLK2
InteractionHNRNPC interactions

TCF4 RC3H2 TRIM37 PPHLN1 SRSF8 ZC3H18

7.85e-05634246int:HNRNPC
InteractionCDC73 interactions

TCF4 RC3H2 ZC3H18 PLG FLG2

7.91e-05386245int:CDC73
InteractionFAM124B interactions

TCF4 TRIM37 ABI1

8.74e-0573243int:FAM124B
InteractionSAMD12 interactions

FLG HRNR

1.05e-0413242int:SAMD12
InteractionTXNIP interactions

PER1 FLG HRNR ZC3HAV1

1.07e-04212244int:TXNIP
InteractionZC3H11A interactions

TRIM37 SRSF8 ZC3H18 NKTR

1.13e-04215244int:ZC3H11A
InteractionFXR1 interactions

RC3H2 TRIM37 PPHLN1 ABI1 ZC3HAV1 SEC16A

1.15e-04679246int:FXR1
InteractionRBBP6 interactions

RC3H2 TRIM37 ZC3H18 PLG

1.15e-04216244int:RBBP6
InteractionCLK3 interactions

RC3H2 PPHLN1 SRSF8 ZC3H18

1.24e-04220244int:CLK3
InteractionBBS7 interactions

PER1 MARCHF7 TRIM37

1.37e-0485243int:BBS7
InteractionHSPB1 interactions

RC3H2 TRIM37 ZC3H18 ABI1 PLG SEC16A

1.44e-04708246int:HSPB1
InteractionZNF214 interactions

TRIM37 ZC3H18

1.61e-0416242int:ZNF214
InteractionKIF20A interactions

TRIM37 PPHLN1 MISP SRSF8 ZC3H18 ZC3HAV1 SEC16A

1.64e-041052247int:KIF20A
InteractionTUBB interactions

MARCHF7 RC3H2 TRIM37 MISP ZC3H18 ABI1

1.77e-04735246int:TUBB
InteractionLUC7L interactions

RC3H2 SRSF8 ZC3H18 NKTR

1.78e-04242244int:LUC7L
InteractionPPP1CC interactions

RC3H2 TRIM37 PPHLN1 MISP ZC3H18 ZC3HAV1

1.81e-04738246int:PPP1CC
InteractionERH interactions

RC3H2 PPHLN1 SRSF8 ZC3H18

1.87e-04245244int:ERH
InteractionBTRC interactions

PER1 MISP SRSF8 HRNR SEC16A FLG2

2.36e-04775246int:BTRC
InteractionRNF214 interactions

RC3H2 ZC3HAV1 SEC16A

2.50e-04104243int:RNF214
InteractionEMD interactions

RC3H2 TRIM37 ZC3H18 CXADR ZC3HAV1 SEC16A

2.60e-04789246int:EMD
InteractionRPL36 interactions

RC3H2 TRIM37 ZC3H18 NKTR ZC3HAV1

2.75e-04504245int:RPL36
InteractionANKHD1-EIF4EBP3 interactions

RC3H2 TRIM37 ZC3HAV1

2.79e-04108243int:ANKHD1-EIF4EBP3
InteractionZNF543 interactions

ZC3H18 NKTR

2.82e-0421242int:ZNF543
InteractionFLG2 interactions

FLG HRNR FLG2

3.11e-04112243int:FLG2
InteractionTNRC6A interactions

RC3H2 TRIM37 ZC3HAV1 SEC16A

3.11e-04280244int:TNRC6A
InteractionTNRC6B interactions

RC3H2 TRIM37 ZC3HAV1 SEC16A

3.20e-04282244int:TNRC6B
InteractionCPSF6 interactions

RC3H2 TRIM37 PPHLN1 ZC3H18 NKTR

3.35e-04526245int:CPSF6
InteractionDRC3 interactions

PER1 MARCHF7

3.39e-0423242int:DRC3
InteractionRPL15 interactions

RC3H2 SRSF8 ZC3H18 NKTR ZC3HAV1

3.47e-04530245int:RPL15
InteractionSRSF2 interactions

TCF4 RC3H2 SRSF8 ZC3H18

3.56e-04290244int:SRSF2
InteractionPRRC2C interactions

RC3H2 ZC3H18 ZC3HAV1 SEC16A

3.56e-04290244int:PRRC2C
InteractionFUBP3 interactions

RC3H2 ZC3H18 ZC3HAV1 SEC16A

3.89e-04297244int:FUBP3
InteractionEIF4ENIF1 interactions

RC3H2 SRSF8 ZC3HAV1 SEC16A

4.04e-04300244int:EIF4ENIF1
InteractionMETTL14 interactions

FLG SRSF8 PLG HRNR FLG2

4.39e-04558245int:METTL14
InteractionRPL36AL interactions

RC3H2 TRIM37 ZC3H18 ZC3HAV1

4.52e-04309244int:RPL36AL
InteractionSFPQ interactions

PER1 TRIM37 PPHLN1 ZC3H18 ZC3HAV1

4.57e-04563245int:SFPQ
InteractionZNF677 interactions

TRIM37 PPHLN1

4.68e-0427242int:ZNF677
InteractionNKAP interactions

RC3H2 ZC3H18 NKTR

5.03e-04132243int:NKAP
InteractionSMG7 interactions

RC3H2 TRIM37 ZC3HAV1 SEC16A

5.10e-04319244int:SMG7
InteractionHRNR interactions

TRIM37 HRNR FLG2

5.14e-04133243int:HRNR
InteractionMAP10 interactions

TRIM37 ZC3H18

5.41e-0429242int:MAP10
InteractionEWSR1 interactions

PER1 RC3H2 TRIM37 ZC3H18 CXADR HRNR

5.44e-04906246int:EWSR1
InteractionARL4C interactions

MISP CXADR ZC3HAV1

5.48e-04136243int:ARL4C
InteractionRBM27 interactions

RC3H2 TRIM37 ZC3H18

5.60e-04137243int:RBM27
InteractionCDK1 interactions

PITPNM1 MISP ZC3H18 HRNR FLG2

5.66e-04590245int:CDK1
InteractionRPL13A interactions

RC3H2 TRIM37 ZC3H18 NKTR ZC3HAV1

5.71e-04591245int:RPL13A
InteractionHTN3 interactions

FLG HRNR

5.79e-0430242int:HTN3
InteractionNCBP2 interactions

RC3H2 ZC3H18 PCIF1

6.09e-04141243int:NCBP2
InteractionFAM83H interactions

TRIM37 PPHLN1 SEC16A

6.09e-04141243int:FAM83H
InteractionCCAR2 interactions

RC3H2 TRIM37 ABI1 SEC16A

6.26e-04337244int:CCAR2
InteractionPPIL1 interactions

TCF4 ZC3H18 COL17A1

6.88e-04147243int:PPIL1
InteractionOGT interactions

TCF4 RC3H2 PPHLN1 CXADR ABI1 ZC3HAV1

6.99e-04950246int:OGT
InteractionAPOBEC3D interactions

PPHLN1 SRSF8 ZC3HAV1

7.01e-04148243int:APOBEC3D
InteractionFBP1 interactions

PLG HRNR ZC3HAV1 FLG2

7.07e-04348244int:FBP1
InteractionMAGEB2 interactions

SRSF8 ZC3H18 NKTR ZC3HAV1

7.14e-04349244int:MAGEB2
InteractionFAM120A interactions

RC3H2 SRSF8 ZC3HAV1 SEC16A

7.14e-04349244int:FAM120A
InteractionARG1 interactions

TRIM37 ZC3H18 FLG2

7.15e-04149243int:ARG1
InteractionHNRNPUL1 interactions

RC3H2 ZC3H18 ZC3HAV1 PCIF1

7.30e-04351244int:HNRNPUL1
InteractionDAXX interactions

TCF4 PPHLN1 ZC3H18 ZC3HAV1

7.45e-04353244int:DAXX
InteractionLUC7L2 interactions

RC3H2 TRIM37 SRSF8 ZC3H18

7.45e-04353244int:LUC7L2
InteractionLMO1 interactions

TCF4 MISP ABI1

7.87e-04154243int:LMO1
InteractionPI4KAP1 interactions

FLG FLG2

7.90e-0435242int:PI4KAP1
InteractionPRC1 interactions

TRIM37 MISP SRSF8 ZC3H18 HRNR ZC3HAV1

7.93e-04973246int:PRC1
InteractionFBL interactions

RC3H2 TRIM37 ZC3H18 ZC3HAV1 SEC16A

8.13e-04639245int:FBL
InteractionRPS19 interactions

RC3H2 TRIM37 SRSF8 ZC3H18 ZC3HAV1

8.13e-04639245int:RPS19
InteractionMYCN interactions

TCF4 PPHLN1 ZC3H18 PLG HRNR ZC3HAV1 FLG2

8.29e-041373247int:MYCN
InteractionVWA2 interactions

MARCHF7 MISP

8.35e-0436242int:VWA2
InteractionSNRNP70 interactions

RC3H2 PPHLN1 SRSF8 ZC3H18 NKTR ZC3HAV1

8.41e-04984246int:SNRNP70
InteractionSUZ12 interactions

RC3H2 TRIM37 SRSF8 ZC3H18 PLG

8.42e-04644245int:SUZ12
InteractionTGM3 interactions

FLG TRIM37 FLG2

8.48e-04158243int:TGM3
InteractionU2AF2 interactions

RC3H2 TRIM37 SRSF8 ZC3H18 NKTR

8.84e-04651245int:U2AF2
InteractionIQCB1 interactions

MARCHF7 HRNR SEC16A FLG2

8.88e-04370244int:IQCB1
InteractionCCDC57 interactions

PER1 PPHLN1 ABI1

9.61e-04165243int:CCDC57
InteractionDCP1A interactions

RC3H2 ZC3HAV1 SEC16A

9.78e-04166243int:DCP1A
InteractionTRA2B interactions

RC3H2 SRSF8 ZC3H18 ABI1

1.03e-03385244int:TRA2B
InteractionZCCHC3 interactions

RC3H2 ZC3H18 ZC3HAV1

1.07e-03171243int:ZCCHC3
InteractionPINK1 interactions

FLG MISP NKTR PLG FLG2

1.07e-03679245int:PINK1
InteractionPRRC2A interactions

RC3H2 ZC3H18 ZC3HAV1 SEC16A

1.07e-03389244int:PRRC2A
InteractionFTH1 interactions

FLG TRIM37 FLG2

1.12e-03174243int:FTH1
Cytoband1q21.3

FLG HRNR FLG2

3.14e-051172431q21.3
CytobandEnsembl 112 genes in cytogenetic band chr1q21

FLG HRNR FLG2

1.19e-03404243chr1q21
GeneFamilyEF-hand domain containing|S100 fused type protein family

FLG HRNR FLG2

2.41e-0871731350
GeneFamilyZinc fingers CCCH-type

RC3H2 ZC3H18 ZC3HAV1

4.44e-063517373
GeneFamilyEF-hand domain containing

FLG HRNR FLG2

1.05e-03219173863
GeneFamilyRing finger proteins

MARCHF7 RC3H2 TRIM37

2.02e-0327517358
GeneFamilyImmunoglobulin like domain containing

CXADR MXRA5

1.39e-02193172594
CoexpressionGSE32901_TH1_VS_TH17_ENRICHED_CD4_TCELL_UP

PITPNM1 ATAD2B ABI1 ZC3HAV1

1.80e-05174244M8925
CoexpressionGSE11924_TFH_VS_TH2_CD4_TCELL_UP

MARCHF7 RC3H2 ZC3H18 ABI1

3.10e-05200244M3153
CoexpressionNABA_MATRISOME_POORLY_METASTATIC_BREAST_CANCER_TUMOR_CELL_DERIVED

COL17A1 FLG2

5.27e-0512242M47985
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

MARCHF7 RC3H2 PPHLN1 CXADR ATAD2B

5.65e-05467245M1347
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

MARCHF7 RC3H2 PPHLN1 CXADR ATAD2B

6.69e-05484245MM999
ToppCellLPS_only-Hematopoietic_Erythro-Megakary-Erythro-Mega-Platelets|LPS_only / Treatment groups by lineage, cell group, cell type

TRIM37 PPHLN1 ZC3H18

5.45e-051382436ddd50e44a3914596b4cd61ae64a987119fe7979
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MXRA5 COL17A1 FLG2

1.01e-041702432d880223d01bde4bf777bd6f50b7d2768489075f
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

MXRA5 COL17A1 FLG2

1.01e-041702430cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCellAT1-AT2_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

MISP CXADR COL17A1

1.05e-041722430be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TCF4 MXRA5 COL17A1

1.05e-04172243aff37b9689b0d30ee7097d997d9588efc475c8fd
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

TCF4 MXRA5 COL17A1

1.05e-04172243bb542f6ca4eb8167129bc84ca1160a54fbb68731
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRIM37 PPHLN1 SRSF8

1.12e-04176243dca70f309af24421f8dc708cbd88512814b8e79e
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

TRIM37 PPHLN1 SRSF8

1.14e-041772439edfb50856f5e10672ab194ce0076d6a190e64de
ToppCell10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-immature_B_cell|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

TCF4 ATAD2B PLG

1.24e-04182243ab78df9de3878a6d67106a40094c893601de8076
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MISP CXADR COL17A1

1.32e-0418624337b93ebd64ebbd08193a746e5bc9b350c2570733
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MISP CXADR COL17A1

1.34e-04187243796046ff066a9c3847faa9bf1f8beccd956c01f7
ToppCelldroplet-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MISP CXADR COL17A1

1.34e-04187243380c3e0bc73b266718893a3b3ca207ce5fd31883
ToppCellfacs-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MISP CXADR COL17A1

1.34e-04187243fe9fc21192ede2eea61f419d20ccda254569d0a6
ToppCelldroplet-Trachea-nan-3m-Epithelial-basal_epithelial_cell_of_tracheobronchial_tree|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MISP CXADR COL17A1

1.34e-041872435b3c3c6421efd25c740ae121968b5520bbdc07b2
ToppCellILEUM-inflamed-(3)_MNP-(3)_moDC|(3)_MNP / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

PER1 NKTR ZC3HAV1

1.34e-041872430099def970fbc828756fbf853eca2ce77b8cd342
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell-basal_epithelial_cell_of_trachea|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MISP CXADR COL17A1

1.36e-04188243137ed9958044fab7a13648affb469585d1c48cf6
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

MISP CXADR COL17A1

1.36e-0418824318698f0b22ccbc2b93759acc1c8dbdb30a6b5a16
ToppCell367C-Epithelial_cells-Epithelial-H_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

MISP CXADR COL17A1

1.36e-0418824361422c7919ca0ea02d6be4302f11b169a3ce35e5
ToppCellfacs-Trachea-3m-Epithelial-airway_epithelial-respiratory_basal_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

MISP CXADR COL17A1

1.36e-041882438ffb5394f7b00ea483a5fe4df894d22fda935e5c
ToppCellrenal_cortex_nuclei-Adult_normal_reference|renal_cortex_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group

PER1 NKTR PLG

1.38e-04189243a48df46274d51e84ffb40264646de7346104efb9
ToppCell(2)_5-FU-(1)_VE-Cad+_vascular_cells|(2)_5-FU / Stress and Cell class

TCF4 TRIM37 CXADR

1.38e-041892430f169b17bb26a812a5b0dcd6e29a3ca8415fd197
ToppCell(2)_5-FU-(1)_VE-Cad+_vascular_cells|World / Stress and Cell class

TCF4 TRIM37 CXADR

1.41e-041902436b391b8a3ffcbdec3acaf242bc52fc3fc9da77c8
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC80 NKTR SEC16A

1.47e-04193243471e65f02937bc18d7c5facdacdf1df58cf0f839
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC80 NKTR SEC16A

1.47e-04193243fe451b3295d77b2bd1ac25cf29310c85835a45fe
ToppCelldroplet-Pancreas-Endocrine-21m|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC80 NKTR SEC16A

1.49e-041942433a3ecedcdc7691cf21775818b598208fcb980c29
ToppCelldroplet-Pancreas-Endocrine-21m-Epithelial|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC80 NKTR SEC16A

1.49e-041942430b023de48ed8a550d169bbe954881eb04bf4f981
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC80 NKTR SEC16A

1.52e-041952437796ea9247f4c63762f0de8490fed08b9717fa23
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UNC80 NKTR SEC16A

1.52e-041952433e519cffa6144a62b06124642a14c9ff39b76554
ToppCellAT1|World / shred by cell class for parenchyma

MISP CXADR COL17A1

1.54e-041962432bc487f8a109a6961ebff111dec79c2227ea60ac
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

MARCHF7 NKTR ZC3HAV1

1.59e-041982434c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellEpithelial_cells-Basal_cells|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id

TCF4 MXRA5 COL17A1

1.59e-041982434235005c49fc2b29ad3a0ee6b608f0109d04f775
ToppCellSkin|World / Skin and Kidney Cells in Lupus Nephritis Patients.

FLG CXADR COL17A1

1.61e-041992436be1340413ee868c610b6e3f58c65b493eb22bb5
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

MISP CXADR COL17A1

1.63e-04200243c7668e26c6b8cfa6d174b0634e43c230425faba9
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MISP CXADR COL17A1

1.63e-04200243621dd6438ef6e71811d3644b75209535b7c0f8f7
ToppCellParenchyma_COVID-19-Epithelial-TX-Basal_2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

MISP CXADR COL17A1

1.63e-04200243bce9bce9eb622bc6514708d49ca4a6604043c22a
ToppCellBiopsy_Other_PF-Epithelial-KRT5-/KRT17+|Biopsy_Other_PF / Sample group, Lineage and Cell type

MISP CXADR COL17A1

1.63e-04200243077e6b9340686de9d0f11b035a8954e1f6a1b790
Drughexametaphosphate

PER1 TRIM37

2.23e-057242CID000024969
DrugCefmetazole sodium salt [56796-39-5]; Down 200; 8.2uM; PC3; HT_HG-U133A

MARCHF7 TCF4 ZC3HAV1 PCIF1

4.95e-051962445868_DN
DrugAminohippuric acid [61-78-9]; Down 200; 20.6uM; HL60; HT_HG-U133A

PITPNM1 PER1 TCF4 NKTR

4.95e-051962443076_DN
Drug(R)-(+)-Atenolol [56715-13-0]; Down 200; 15uM; HL60; HT_HG-U133A

PITPNM1 TCF4 ZC3HAV1 PCIF1

4.95e-051962442496_DN
DrugICI182,780; Up 200; 1uM; PC3; HT_HG-U133A

MARCHF7 TCF4 RC3H2 ATAD2B

5.04e-051972447096_UP
Drug(-)-MK 801 hydrogen maleate [77086-19-2]; Down 200; 11.8uM; HL60; HT_HG-U133A

PER1 TCF4 ZC3HAV1 PCIF1

5.14e-051982443081_DN
Drug(1-[(4-Chlorophenyl)phenyl-methyl]-4-methylpiperazine) [1620-21-9]; Up 200; 11.8uM; HL60; HT_HG-U133A

PER1 TCF4 NKTR COL17A1

5.14e-051982442197_UP
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

PLG PCIF1

2.93e-0434222EFO_0008317, EFO_0008596, EFO_0020944
Diseasechylomicron measurement, triglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

PLG PCIF1

2.93e-0434222EFO_0008317, EFO_0008596, EFO_0020947
Diseasefree cholesterol to total lipids in large VLDL percentage

PCIF1 SEC16A

3.48e-0437222EFO_0022281
Diseasecholesteryl esters to total lipids in small LDL percentage

PLG PCIF1

4.49e-0442222EFO_0022255
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

PLG PCIF1

4.49e-0442222EFO_0008317, EFO_0008596, EFO_0020945
Diseasefree cholesterol to total lipids in very small VLDL percentage

PLG PCIF1

4.70e-0443222EFO_0022290
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

PLG PCIF1

5.38e-0446222EFO_0008317, EFO_0008596, EFO_0020943
Diseasevery low density lipoprotein cholesterol measurement, cholesterol:total lipids ratio

PLG PCIF1 SEC16A

5.82e-04222223EFO_0008317, EFO_0020943
Diseasetriglycerides:total lipids ratio, very low density lipoprotein cholesterol measurement

PLG PCIF1 SEC16A

6.05e-04225223EFO_0008317, EFO_0020947
Diseasesitting height ratio

TCF4 ATAD2B

6.62e-0451222EFO_0007118
Diseasepolyunsaturated fatty acids to monounsaturated fatty acids ratio

PLG PCIF1

6.62e-0451222EFO_0022302
Diseasetriglycerides in HDL measurement

PLG PCIF1

7.15e-0453222EFO_0022317
Diseasevery low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio

PLG PCIF1 SEC16A

7.21e-04239223EFO_0008317, EFO_0020945
Diseasetriglycerides in medium HDL measurement

PLG PCIF1

7.42e-0454222EFO_0022321
Diseasecholesterol to total lipids in large LDL percentage

PLG PCIF1

7.98e-0456222EFO_0022235
Diseasetriglycerides in LDL measurement

PLG PCIF1

7.98e-0456222EFO_0022320
Diseasetriglycerides to total lipids in medium HDL percentage

PLG PCIF1

7.98e-0456222EFO_0022333
Diseaselow density lipoprotein particle size measurement

PLG PCIF1

8.55e-0458222EFO_0008593
Diseasecholesterol to total lipids in medium HDL percentage

PLG PCIF1

9.15e-0460222EFO_0022237
Diseasetriglycerides to total lipids in large HDL percentage

PLG PCIF1

9.15e-0460222EFO_0022330
Diseasefree cholesterol to total lipids in medium HDL percentage

PLG PCIF1

9.15e-0460222EFO_0022282
Diseasetriglycerides in small VLDL measurement

PLG PCIF1

9.46e-0461222EFO_0022145
Diseasefree cholesterol in HDL measurement

PLG PCIF1

9.46e-0461222EFO_0022264
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

PLG PCIF1

9.46e-0461222EFO_0008317, EFO_0008596, EFO_0020946
Diseasevery low density lipoprotein cholesterol measurement, cholesteryl esters:total lipids ratio

PLG PCIF1 SEC16A

9.61e-04264223EFO_0008317, EFO_0020944
Diseasetriglycerides in medium LDL measurement

PLG PCIF1

9.77e-0462222EFO_0022322
Diseasetriglycerides to total lipids in very large HDL percentage

PLG PCIF1

9.77e-0462222EFO_0022339
Diseasetriglycerides in small HDL measurement

PLG PCIF1

9.77e-0462222EFO_0022158
Diseasephospholipids in large VLDL measurement

PLG PCIF1

9.77e-0462222EFO_0022169
Diseasefree cholesterol to total lipids in medium LDL percentage

PLG PCIF1

1.01e-0363222EFO_0022283
Diseasetriglycerides in small LDL measurement

PLG PCIF1

1.07e-0365222EFO_0022323
Diseasecholesterol to total lipids in very small VLDL percentage

PLG PCIF1

1.14e-0367222EFO_0022245
Diseasetriglycerides to phosphoglycerides ratio

PLG PCIF1

1.17e-0368222EFO_0022327
Diseasefree cholesterol in large VLDL measurement

PLG PCIF1

1.17e-0368222EFO_0022265
Diseasefatty acid measurement, linoleic acid measurement

PLG PCIF1

1.17e-0368222EFO_0005110, EFO_0006807
Diseasetriglycerides to total lipids in very small VLDL percentage

PLG PCIF1

1.21e-0369222EFO_0022341
Diseasetriglycerides to total lipids in small HDL percentage

PLG PCIF1

1.31e-0372222EFO_0022336
Diseasephospholipids in large HDL measurement

PLG PCIF1

1.35e-0373222EFO_0022190
Diseasefree cholesterol to total lipids in large LDL percentage

PLG PCIF1

1.39e-0374222EFO_0022280
Diseasetotal lipids in large HDL

PLG PCIF1

1.39e-0374222EFO_0022189
Diseasefree cholesterol to total lipids in small VLDL percentage

PLG PCIF1

1.42e-0375222EFO_0022287
Diseasefeeling "fed-up" measurement

TCF4 ATAD2B

1.46e-0376222EFO_0009588
Diseasemonounsaturated fatty acids; 16:1, 18:1 measurement

PLG PCIF1

1.54e-0378222EFO_0022187
Diseasecholesterol in large HDL measurement

PLG PCIF1

1.62e-0380222EFO_0021900

Protein segments in the cluster

PeptideGeneStartEntry
NSTGSTRGHASTSSY

COL17A1

66

Q9UMD9
GSSSSSHSSSVRRGS

COL17A1

1291

Q9UMD9
SHSSSVRRGSSYSSS

COL17A1

1296

Q9UMD9
HNSTTSSTSSGGYRR

ABI1

321

Q8IZP0
RSGRSGSSLYQVSTH

FLG

461

P20930
GAISRSSRTGYHTTD

RC3H2

906

Q9HBD1
SRSSSQASGITGSYS

MISP

586

Q8IVT2
SRSGQSSYGQHSSGS

FLG2

611

Q5D862
ATGGSSHFISSRTRS

ATAD2B

31

Q9ULI0
STFHRSGTNHYSTSS

TCF4

281

P15884
TRSSQSSHTSKYFGS

PER1

1086

O15534
ERHRSSSGSSSSYGQ

HRNR

271

Q86YZ3
SSGQHGSSSRQSSSY

HRNR

386

Q86YZ3
GSSSRQSSSYGQHES

HRNR

391

Q86YZ3
SYEQHGSRSGQSSRS

HRNR

956

Q86YZ3
GERHGSSSRSSSRYG

HRNR

1676

Q86YZ3
SSSRSSSRYGQHGSG

HRNR

1681

Q86YZ3
AYRQSGRSHSSGSSS

PCIF1

666

Q9H4Z3
SRTSTARSYIGSNHS

CXADR

286

P78310
SGSRGSSLNDTYHSR

MARCHF7

26

Q9H992
THRRNTSTSSSASGG

FAM102A

256

Q5T9C2
VSGYSTCHSRSSSFS

FAM102B

216

Q5T8I3
PHSRSGSSVSSRSYS

PPHLN1

141

Q8NEY8
SSHGYVGSSSRISRR

TRIM37

586

O94972
SKSHSQSYSRGSSRS

NKTR

521

P30414
SRYHSSRSHSKSGSS

SRSF8

201

Q9BRL6
DGQSYRGTSSTTTTG

PLG

381

P00747
SSSRSSYSSQHGGAV

PITPNM1

311

O00562
TSSTSHRNYSFRRGS

UNC80

1796

Q8N2C7
VSSSYSSRSHGRLSG

SEC16A

521

O15027
STRSLNYKSTSSGHR

ZC3HAV1

441

Q7Z2W4
RSSSRSSSYSGSGSS

ZC3H18

556

Q86VM9
SSSYSGSGSSRSRSR

ZC3H18

561

Q86VM9
GSGSSRSRSRSSSYS

ZC3H18

566

Q86VM9
SYSSRSSRHSSFSGS

ZC3H18

581

Q86VM9
SGSSYSGSSSRSRSL

ZC3H18

691

Q86VM9
HRYTPSTVSSRASGS

MXRA5

1241

Q9NR99