Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	mRNA metabolic process	SETX TENT4A SNRNP35 LARP1B RBM23 RXRB SRSF12 ZRSR2P1 TCERG1 RBM7 GIGYF2 SCAF11 FTO SRRM2 SMG6	8.20e-06	917	89	15	GO:0016071
Domain	TF_fork_head_CS_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	3.04e-06	46	92	5	IPR030456
Domain	TF_fork_head_CS_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	3.39e-06	47	92	5	IPR018122
Domain	FH	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.18e-06	49	92	5	SM00339
Domain	FORK_HEAD_1	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.18e-06	49	92	5	PS00657
Domain	FORK_HEAD_2	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.18e-06	49	92	5	PS00658
Domain	Fork_head_dom	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.18e-06	49	92	5	IPR001766
Domain	FORK_HEAD_3	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.18e-06	49	92	5	PS50039
Domain	Forkhead	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.18e-06	49	92	5	PF00250
Domain	GYF	GIGYF1 GIGYF2	7.18e-05	3	92	2	SM00444
Domain	GYF	GIGYF1 GIGYF2	7.18e-05	3	92	2	PS50829
Domain	GYF	GIGYF1 GIGYF2	7.18e-05	3	92	2	PF02213
Domain	-	GIGYF1 GIGYF2	7.18e-05	3	92	2	3.30.1490.40
Domain	-	CUL9 FOXD4L6 LARP1B FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	1.01e-04	218	92	7	1.10.10.10
Domain	GYF	GIGYF1 GIGYF2	1.43e-04	4	92	2	IPR003169
Domain	WHTH_DNA-bd_dom	CUL9 FOXD4L6 LARP1B FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	1.93e-04	242	92	7	IPR011991
Domain	VPS9	RIN3 RIN2	6.59e-04	8	92	2	SM00167
Domain	RRM_dom	SNRNP35 RBM23 SRSF12 ZRSR2P1 RBM7 NXF1	9.01e-04	227	92	6	IPR000504
Domain	RRM	SNRNP35 RBM23 SRSF12 ZRSR2P1 RBM7 NXF1	9.65e-04	230	92	6	PS50102
Domain	VPS9	RIN3 RIN2	1.05e-03	10	92	2	PS51205
Domain	VPS9	RIN3 RIN2	1.05e-03	10	92	2	PF02204
Domain	VPS9	RIN3 RIN2	1.05e-03	10	92	2	IPR003123
Pubmed	Neural transcription factors bias cleavage stage blastomeres to give rise to neural ectoderm.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	9.59e-13	6	98	5	27092474
Pubmed	The mouse fkh-2 gene. Implications for notochord, foregut, and midbrain regionalization.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	8.91e-12	8	98	5	8530406
Pubmed	An amphioxus winged helix/forkhead gene, AmphiFoxD: insights into vertebrate neural crest evolution.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	2.00e-11	9	98	5	12412011
Pubmed	A genetic study of the suppressors of the Engrailed-1 cerebellar phenotype.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	2.03e-10	13	98	5	16884697
Pubmed	Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	2.03e-10	13	98	5	7957066
Pubmed	FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4	2.96e-10	5	98	4	12234674
Pubmed	Six members of the mouse forkhead gene family are developmentally regulated.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.70e-10	15	98	5	7689224
Pubmed	Strain-specific modifier genes of Cecr2-associated exencephaly in mice: genetic analysis and identification of differentially expressed candidate genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.70e-10	15	98	5	22045912
Pubmed	Expression of the winged helix genes fkh-4 and fkh-5 defines domains in the central nervous system.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	6.83e-10	16	98	5	8861101
Pubmed	Developmental competence of the gut endoderm: genetic potentiation by GATA and HNF3/fork head proteins.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	6.83e-10	16	98	5	10208738
Pubmed	Functional equivalency between Otx2 and Otx1 in development of the rostral head.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	1.81e-09	19	98	5	9895322
Pubmed	Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	2.40e-09	20	98	5	12812790
Pubmed	Sequential roles for Otx2 in visceral endoderm and neuroectoderm for forebrain and midbrain induction and specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	3.15e-09	21	98	5	9449667
Pubmed	Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	4.06e-09	22	98	5	17389379
Pubmed	Otx2 is required to respond to signals from anterior neural ridge for forebrain specification.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	6.53e-09	24	98	5	11820816
Pubmed	A Requirement for Zic2 in the Regulation of Nodal Expression Underlies the Establishment of Left-Sided Identity.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	6.53e-09	24	98	5	29992973
Pubmed	Ssdp1 regulates head morphogenesis of mouse embryos by activating the Lim1-Ldb1 complex.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	1.01e-08	26	98	5	15857913
Pubmed	Molecular profiling of synovial joints: use of microarray analysis to identify factors that direct the development of the knee and elbow.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	1.80e-08	29	98	5	22972626
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	SETX BCLAF1 DHX37 MRPL55 PEG3 PACSIN3 LARP1B RBM23 LUZP1 CEP170 RCC1L TCERG1 OSBPL3 RBM7 SCAF11 NXF1 DDX28	2.71e-07	1371	98	17	36244648
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	KIF23 BCLAF1 DHX37 PACSIN3 INO80 LUZP1 PNPLA6 TCERG1 OSBPL3 RBM7 GIGYF2 SCAF11 SRRM2	7.73e-07	847	98	13	35850772
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	KIF23 SETX GIGYF1 LARP1B LUZP1 CEP170 MAST4 TCERG1 OSBPL3 RBM7 GIGYF2 PLCH1 SRRM2	9.28e-07	861	98	13	36931259
Pubmed	Genome-scale study of transcription factor expression in the branching mouse lung.	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	1.35e-06	67	98	5	22711520
Pubmed	Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.	FOXD4L4 FOXD4L3 FOXD4	3.52e-06	11	98	3	12421752
Pubmed	Screening for coding variants in FTO and SH2B1 genes in Chinese patients with obesity.	SH2B1 FTO	7.86e-06	2	98	2	23825611
Pubmed	The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.	KIF23 SETX BCLAF1 LUZP1 TASOR2 SRSF12 CEP170 TCERG1 RBM7 GIGYF2 SCAF11 SRRM2	1.58e-05	954	98	12	36373674
Pubmed	The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.	BCLAF1 LARP1B SRSF12 RCC1L TCERG1 RBM7 GIGYF2 SCAF11 SRRM2 NXF1 DDX28	1.76e-05	807	98	11	22681889
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	SETX PIEZO1 PACSIN3 INO80 RBM23 LUZP1 MYOF PNPLA6 TCERG1 RBM7 CTBP1 SCAF11 NXF1 DDX28 SMG6	1.91e-05	1497	98	15	31527615
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ADAM9 PEG3 FRMPD1 DGKB CUL9 GIGYF2 ARRDC3 SRRM2	2.06e-05	407	98	8	12693553
Pubmed	Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.	SH2B1 GIPR FTO GPRC5B	2.24e-05	58	98	4	20935630
Pubmed	Diverse fates of paralogs following segmental duplication of telomeric genes.	FOXD4L4 FOXD4L3 FOXD4	3.21e-05	22	98	3	15233989
Pubmed	Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.	LCORL SH2B1 GIPR FTO GPRC5B	3.35e-05	129	98	5	23563607
Pubmed	A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility.	GIPR ZNF45	4.70e-05	4	98	2	19195718
Pubmed	4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay.	GIGYF1 GIGYF2	4.70e-05	4	98	2	33053355
Pubmed	Genetic testing for retinal dystrophies and dysfunctions: benefits, dilemmas and solutions.	CACNA1F GUCY2D	4.70e-05	4	98	2	17651254
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	SETX BCLAF1 DHX37 MRPL55 INO80 CEP170 TCERG1 MAMDC2 RBM7 CTBP1 SRRM2 NXF1	5.37e-05	1082	98	12	38697112
Pubmed	The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling.	GIGYF1 GIGYF2	7.82e-05	5	98	2	16037382
Pubmed	Evaluation of genetic susceptibility loci for obesity in Chinese women.	SH2B1 FTO	7.82e-05	5	98	2	20616199
Pubmed	A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5.	RIN3 RIN2	7.82e-05	5	98	2	11733506
Pubmed	Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.	GIGYF1 GIGYF2	7.82e-05	5	98	2	12771153
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	NAT14 ADAM9 PIEZO1 TASOR2 CEP170 MYOF PNPLA6 SRRM2	8.64e-05	499	98	8	22810586
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	SETX DHX37 ADAM9 GIGYF1 TCERG1 OSBPL3 GIGYF2 PLCH1 NXF1	9.45e-05	650	98	9	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	KIF23 DHX37 CUL9 TASOR2 CEP170 GIGYF2 SCAF11 SRRM2 NXF1	9.78e-05	653	98	9	22586326
Pubmed	Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.	FOXD4L6 RXRB FOXD4L5 FOXD4L4 FOXD4L3 FOXD4	1.04e-04	263	98	6	20932939
Pubmed	Critical involvement of RQCD1 in the EGFR-Akt pathway in mammary carcinogenesis.	GIGYF1 GIGYF2	1.17e-04	6	98	2	20878056
Pubmed	GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.	GIGYF1 GIGYF2	1.17e-04	6	98	2	28698298
Pubmed	RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.	RIN3 RIN2	1.17e-04	6	98	2	12972505
Pubmed	A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity.	LCORL CTBP1	1.17e-04	6	98	2	31041561
Pubmed	GIGYF2 gene disruption in mice results in neurodegeneration and altered insulin-like growth factor signaling.	GIGYF1 GIGYF2	1.17e-04	6	98	2	19744960
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SETX BCLAF1 PIEZO1 INO80 MAST4 SCAF11 FTO SMG6	1.29e-04	529	98	8	14621295
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	BCLAF1 LARP1B LUZP1 CEP170 GIGYF2 NXF1	1.30e-04	274	98	6	34244482
Pubmed	Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q.	ZNF785 ABCC6 DDX28 GPRC5B	1.37e-04	92	98	4	10493829
Pubmed	GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling.	GIGYF1 GIGYF2	1.64e-04	7	98	2	30917308
Pubmed	Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA.	SH2B1 FTO	1.64e-04	7	98	2	20386550
Pubmed	ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands.	ADAM9 PACSIN3	1.64e-04	7	98	2	15280379
Pubmed	A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development.	GIGYF1 GIGYF2	1.64e-04	7	98	2	22751931
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	KIF23 LCORL BCLAF1 DHX37 TASOR2 TCERG1 SRRM2	1.68e-04	411	98	7	35182466
Pubmed	Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SETX CUL9 OSBPL3 GIGYF2	2.04e-04	102	98	4	9734811
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	BCLAF1 DHX37 INO80 LARP1B LUZP1 CEP170 MYOF GIGYF2 NXF1	2.11e-04	724	98	9	36232890
Pubmed	Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms.	DGKB ZBED3 FTO	2.14e-04	41	98	3	20889853
Pubmed	Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.	ADAM9 PACSIN3	2.18e-04	8	98	2	10531379
Pubmed	MC4R variant is associated with BMI but not response to resistance training in young females.	SH2B1 FTO	2.18e-04	8	98	2	20725061
Pubmed	Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.	KIF23 BCLAF1 DHX37 PACSIN3 LUZP1 TASOR2 CEP170 MYOF PNPLA6 TCERG1 SCAF11 NXF1	2.19e-04	1257	98	12	36526897
Pubmed	A non-proteolytic role for ubiquitin in deadenylation of MHC-I mRNA by the RNA-binding E3-ligase MEX-3C.	DHX37 GIGYF2 NXF1	2.64e-04	44	98	3	26471122
Pubmed	Molecular basis for GIGYF-Me31B complex assembly in 4EHP-mediated translational repression.	GIGYF1 GIGYF2	2.79e-04	9	98	2	31439631
Pubmed	Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden.	SH2B1 FTO	2.79e-04	9	98	2	19164386
Pubmed	Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.	IQCH FTO SLC14A2	3.02e-04	46	98	3	21102462
Pubmed	Tumor-associated antigen Prame targets tumor suppressor p14/ARF for degradation as the receptor protein of CRL2Prame complex.	FBXW9 CUL9 KLHL15	3.42e-04	48	98	3	33504946
Pubmed	Human CCAAT/enhancer-binding protein β interacts with chromatin remodeling complexes of the imitation switch subfamily.	INO80 RXRB RBM7	3.42e-04	48	98	3	22242598
Pubmed	Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?	SH2B1 FTO	3.48e-04	10	98	2	19746409
Pubmed	Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference.	SH2B1 FTO	3.48e-04	10	98	2	19692490
Pubmed	Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.	GIPR FTO	3.48e-04	10	98	2	22344221
Pubmed	Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.	SH2B1 FTO	4.25e-04	11	98	2	19079261
Pubmed	Poly(ADP-ribosyl)ation of BRD7 by PARP1 confers resistance to DNA-damaging chemotherapeutic agents.	BCLAF1 DHX37 LARP1B CEP170 SRRM2 GPRASP2 NXF1	4.62e-04	486	98	7	30940648
Pubmed	Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans.	DGKB GIPR	5.09e-04	12	98	2	20185807
Pubmed	Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.	TENT4A DGKB	5.09e-04	12	98	2	23776197
Pubmed	Genome-wide association study of height and body mass index in Australian twin families.	LCORL FTO	5.09e-04	12	98	2	20397748
Pubmed	ZZW-115-dependent inhibition of NUPR1 nuclear translocation sensitizes cancer cells to genotoxic agents.	KIF23 BCLAF1 PACSIN3 LUZP1 MYOF TCERG1 CTBP1 SRRM2	5.67e-04	660	98	8	32780723
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	BCLAF1 CEP170 SRRM2	6.29e-04	59	98	3	16083285
Pubmed	SLFN11 promotes CDT1 degradation by CUL4 in response to replicative DNA damage, while its absence leads to synthetic lethality with ATR/CHK1 inhibitors.	SETX DHX37 TCERG1 SRRM2 NXF1	7.27e-04	250	98	5	33536335
Pubmed	Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.	KIF23 BCLAF1 CEP170 OSBPL3 SRRM2	7.94e-04	255	98	5	15324660
Pubmed	Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products.	PIEZO1 PACSIN3	8.06e-04	15	98	2	18316326
Pubmed	Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese.	SH2B1 FTO	8.06e-04	15	98	2	20215397
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	KIF23 LUZP1 CEP170 MYOF GIGYF2	8.09e-04	256	98	5	33397691
Pubmed	Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies.	SH2B1 FTO	9.19e-04	16	98	2	20724581
Pubmed	RNA-binding proteins with basic-acidic dipeptide (BAD) domains self-assemble and aggregate in Alzheimer's disease.	BCLAF1 MRPL55 SNRNP35 LARP1B SRSF12 CEP170 SRRM2 NXF1	9.35e-04	713	98	8	29802200
Pubmed	Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.	RXRB ARRDC3	1.04e-03	17	98	2	28291835
Pubmed	Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.	DGKB GIPR FTO	1.12e-03	72	98	3	24509480
Pubmed	A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.	LCORL CTBP1	1.17e-03	18	98	2	29628311
Pubmed	Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb.	BCLAF1 SRRM2	1.17e-03	18	98	2	23211419
Pubmed	Jumonji modulates polycomb activity and self-renewal versus differentiation of stem cells.	SETX BCLAF1	1.17e-03	18	98	2	20064376
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	LCORL LUZP1 GIGYF2 CTBP1 GPRASP2 NXF1	1.21e-03	418	98	6	34709266
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	PSD CUL9 GIGYF1 INO80 LUZP1 CEP170 PNPLA6 OSBPL3 RBM7 SRRM2	1.21e-03	1116	98	10	31753913
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	EPHB2 SETX BCLAF1 CEP170 GIGYF2 SRRM2	1.24e-03	420	98	6	28065597
Pubmed	Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population.	DGKB SH2B1 FTO	1.26e-03	75	98	3	20571754
Pubmed	Proteomic analysis of SRm160-containing complexes reveals a conserved association with cohesin.	BCLAF1 RBM23 RBM7 SRRM2	1.39e-03	170	98	4	16159877
Pubmed	Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.	SH2B1 FTO	1.44e-03	20	98	2	19079260
Pubmed	TBK1 phosphorylation activates LIR-dependent degradation of the inflammation repressor TNIP1.	KIF23 BCLAF1 DHX37 LUZP1 TCERG1 OSBPL3 SRRM2 NXF1 DDX28	1.46e-03	949	98	9	36574265
Pubmed	Luzp4 defines a new mRNA export pathway in cancer cells.	BCLAF1 LUZP1 NXF1	1.52e-03	80	98	3	25662211
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	KIF23 BCLAF1 MYOF PNPLA6 RBM7 GIGYF2 SCAF11 SRRM2	1.57e-03	774	98	8	15302935
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	KIF23 BCLAF1 LUZP1 CEP170 PNPLA6 GIGYF2 SCAF11	1.59e-03	601	98	7	33658012
Cytoband	9q21.11	FOXD4L6 FOXD4L5 FOXD4L4 FOXD4L3	5.13e-07	30	98	4	9q21.11
Cytoband	19q13.4	GP6 PEG3 LENG9	6.63e-04	79	98	3	19q13.4
Cytoband	Ensembl 112 genes in cytogenetic band chr9q21	FOXD4L5 FOXD4L4 FOXD4L3 MAMDC2	9.00e-04	199	98	4	chr9q21
Cytoband	Ensembl 112 genes in cytogenetic band chr19q13	GP6 SRRM5 NAT14 FKRP PEG3 LENG9 GIPR ZNF45 NCR1	1.04e-03	1192	98	9	chr19q13
Cytoband	10q24	PSD MYOF	2.56e-03	35	98	2	10q24
GeneFamily	VPS9 domain containing	RIN3 RIN2	5.45e-04	10	64	2	928
GeneFamily	RNA binding motif containing	SNRNP35 RBM23 SRSF12 ZRSR2P1 RBM7	9.39e-04	213	64	5	725
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FOXD4L5 SRSF12 FOXD4L4 FOXD4L3 CHST7 FOXD4 TLCD5	1.49e-07	180	98	7	32d871738a24071b70084a7e80148a516110c78b
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_10\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FOXD4L5 SRSF12 FOXD4L4 FOXD4L3 CHST7 FOXD4 TLCD5	1.49e-07	180	98	7	067ca8a15228c7f3b3bc7aecbc9b1611ca05e176
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB2 XKR6 LENG9 ZNF786 FGF14 GPRASP2	3.12e-06	182	98	6	1923932a9c60e9ec33db69ded441210d1fb07bec
ToppCell	PND10-Epithelial-Epithelial_Airway-Neurosecretory-PNEC-PNEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	EPHB2 XKR6 LENG9 ZNF786 FGF14 GPRASP2	3.12e-06	182	98	6	69ff652f74cc47fbe0bd665ab17c445c5b959dad
Disease	congenital stationary night blindness (is_implicated_in)	CACNA1F GUCY2D	4.79e-05	4	84	2	DOID:0050534 (is_implicated_in)
Disease	Cone-Rod Dystrophy 2	CACNA1F ADAM9 GUCY2D	7.71e-05	29	84	3	C3489532
Disease	Congenital dyserythropoietic anemia, type III	KIF23 KLF1	7.96e-05	5	84	2	C0271934
Disease	HbA1c measurement, polycystic ovary syndrome	GIPR FTO	7.96e-05	5	84	2	EFO_0000660, EFO_0004541
Disease	osteoarthritis, knee	PIEZO1 SNRNP35 XKR6 FTO SMG6	9.07e-05	158	84	5	EFO_0004616
Disease	Congenital dyserythropoietic anemia	KIF23 KLF1	1.19e-04	6	84	2	cv:C0002876
Disease	insulin measurement, glucose tolerance test	DHX37 GIPR	1.19e-04	6	84	2	EFO_0004307, EFO_0004467
Disease	waist-hip ratio	EPHB2 NAT14 IQCH LCORL DGKB CUL9 SH2B1 GIPR MAST4 FTO SLC14A2 SMG6	1.79e-04	1226	84	12	EFO_0004343
Disease	physical activity measurement, body mass index	SH2B1 GIPR FTO GPRC5B	3.21e-04	114	84	4	EFO_0004340, EFO_0008002
Disease	polycystic ovary syndrome, type 2 diabetes mellitus	GIPR FTO	3.55e-04	10	84	2	EFO_0000660, MONDO_0005148
Disease	body mass index, osteoarthritis	XKR6 FTO GPRC5B	4.97e-04	54	84	3	EFO_0004340, MONDO_0005178
Disease	choline measurement	TENT4A MYO1H CYP2W1 PLCH1	5.28e-04	130	84	4	EFO_0010116
Disease	mean arterial pressure	LCORL XKR6 RBM23 CEP170 FTO SMG6 TLCD5	5.59e-04	499	84	7	EFO_0006340
Disease	coronary artery disease	TENT4A LCORL INO80 GIPR MAST4 GIGYF2 SCAF11 FTO SLC14A2 SMG6 TLCD5	5.65e-04	1194	84	11	EFO_0001645
Disease	breast carcinoma	RIN3 SERTAD4-AS1 TASOR2 GIPR ZNF45 RIN2 ARRDC3 FTO SLC14A2 SMG6	6.31e-04	1019	84	10	EFO_0000305
Disease	glucose measurement	LCORL DGKB GIGYF1 GIPR CTBP1 FTO	7.66e-04	380	84	6	EFO_0004468
Disease	Body Weight	GIPR FTO	8.21e-04	15	84	2	C0005910
Disease	comparative body size at age 10, self-reported	SH2B1 GIPR MAST4 FTO GPRC5B SMG6	1.28e-03	420	84	6	EFO_0009819
Disease	cardiovascular system disease (is_implicated_in)	GIPR FTO	1.62e-03	21	84	2	DOID:1287 (is_implicated_in)
Disease	systemising measurement	FATE1 CEP170	1.62e-03	21	84	2	EFO_0010221
Disease	bone density, lean body mass	RIN3 FTO	1.62e-03	21	84	2	EFO_0003923, EFO_0004995
Disease	Nystagmus	MAST4 FGF14	1.62e-03	21	84	2	HP_0000639
Disease	forced expiratory volume	NAT14 RIN3 LCORL PIEZO1 DGKB INO80 SH2B1 SLC14A2	1.84e-03	789	84	8	EFO_0004314
Disease	alcohol use disorder (implicated_via_orthology)	PSD GIPR CTBP1 SRRM2	2.36e-03	195	84	4	DOID:1574 (implicated_via_orthology)
Disease	body surface area	TENT4A LCORL LUZP1 GIPR GIGYF2 FTO GPRC5B	2.40e-03	643	84	7	EFO_0022196
Disease	vital capacity	RIN3 IQCH LCORL PIEZO1 FRMPD1 INO80 DNM1P46 SH2B1 SLC14A2 SMG6	2.66e-03	1236	84	10	EFO_0004312
Disease	body fat distribution	LCORL XKR6 SH2B1 FTO	2.68e-03	202	84	4	EFO_0004341
Disease	lean mass-adjusted fat body mass, femoral neck bone mineral density	RIN2 SMG6	2.68e-03	27	84	2	EFO_0007785, EFO_0009890
Disease	hip circumference	LCORL DHX37 GIPR FTO GPRC5B	2.82e-03	338	84	5	EFO_0005093

Protein segments in the cluster

Peptide	Gene	Start	Entry
HMERAVWAARRAAAR	ADAT3	176	Q96EY9
SRKHRPRSRRLEDAW	CCDC185	96	Q8N715
DHLTITRRRTWSRDE	CEP170	1396	Q5SW79
SERKRHLERNWSGRG	SMG6	321	Q86US8
DWRIFHRLALGSRRA	ANTXRL	36	A6NF34
RRATWLHQALREGTR	CTBP1	141	Q13363
ARWHRGRLSSQQRLR	C9orf163	36	Q8N9P6
RLGTRRHSWRSRQSR	DNM1P46	146	Q6ZS02
RWRAARQFTVRALHS	CYP2W1	121	Q8TAV3
SEIRRGWHHCRLRRS	GIPR	401	P48546
ARGHAKVRWTESRNA	ARRDC3	51	Q96B67
HWRRLIRGATRDDDS	ATP10D	11	Q9P241
WTAAGRSRSRREAAE	RCC1L	26	Q96I51
RSRSWDRRHGSESRS	RBM23	101	Q86U06
HLAANWNRIRTSRRT	IQCH	436	Q86VS3
RVFNHSRDRWLRVLS	INO80	851	Q9ULG1
EKRNRSSWHRRRGET	MAMDC2	521	Q7Z304
RRRGRLRWFSHSTRS	CACNA1F	446	O60840
ERSASRTKQRAREWA	PNPLA6	1026	Q8IY17
DHVTWRLRALRRVRA	FBXW9	116	Q5XUX1
RRRRVAKATAHNSSW	MAGEE1	11	Q9HCI5
RSAGWREHGERRRKF	GIGYF1	236	O75420
KRTRERASRASTWEG	NCR1	281	O76036
RASRASTWEGRRRLN	NCR1	286	O76036
RWVSGAAVARHIRDA	GUCY2D	371	Q02846
SLGRRARVWRRHREA	FOXD4L4	306	Q8WXT5
ARVWRRHREADASLS	FOXD4L4	311	Q8WXT5
SLGRRARVWRRHREA	FOXD4L3	306	Q6VB84
ARVWRRHREADASLS	FOXD4L3	311	Q6VB84
SLTARQNLRREWHAR	FTO	441	Q9C0B1
AERRGFRRELDSWRH	LCORL	31	Q8N3X6
NWLRTKFIRRRGAHR	EPHB2	71	P29323
FLAEDWHSRRKRLRH	GP6	286	Q9HCN6
DGARVTRLSVSRWHR	NAT14	121	Q8WUY8
RFHGRLVWDRASRTD	LENG9	151	Q96B70
RRGDTWHDRDRIHVT	NXF1	81	Q9UBU9
AREQHWDRPSASRRR	FGF14	16	Q92915
GWKSRRARRDHFSIE	DDX28	96	Q9NUL7
LASLERERARAHWRA	nan	31	B2RBV5
RARVWRRHREADASL	FOXD4	306	Q12950
SVHSFSDRDWDRRGR	PEG3	156	Q9GZU2
RTGWRRKKHTHTRDS	TENT4A	751	Q5XG87
LSQAWRVRRLVRHGT	GPRC5B	141	Q9NZH0
RGRRSWARKRQAAHT	KLF1	266	Q13351
VQSWLRHDRRRWRHT	KLHL15	201	Q96M94
HRRWQSTVEISARAR	DACT2	606	Q5SW24
RSAGWREHMERRRRF	GIGYF2	241	Q6Y7W6
TVAHDVSARDWLTRR	FAHD2B	186	Q6P2I3
RGWVDHRRLAVNSFR	CYP2R1	131	Q6VVX0
VARWLRRSRDSSARA	FRMPD1	21	Q5SYB0
VWNRRHSRSPRRGRS	BCLAF1	96	Q9NYF8
SNLWGESKKRRSHRR	DGKB	671	Q9Y6T7
QWREKFLITRRRHDS	ADAM9	286	Q13443
PARHSRRRASWVSRW	FRMD6-AS1	336	P0C7T7
RHVTVRNAWKSRRDL	LUZP1	916	Q86V48
AHFSFARRTDGRRWS	MAST4	271	O15021
RAQAWSRDIAEDHRR	CUL9	1321	Q8IWT3
WIKETRTRHLRSRDF	DALRD3	26	Q5D0E6
RRLRALEEQGATWRH	FATE1	146	Q969F0
AHARWKAEREGRARR	FKRP	251	Q9H9S5
LSGAHRKRRRWPSAE	DHX37	146	Q8IY37
ERRTRKWSRSRSHSR	SCAF11	926	Q99590
AITTASIRRHRWRRE	FAM126B	316	Q8IXS8
HNNRRNDTRSWKRDR	LARP1B	111	Q659C4
RSHRRWRSRAIGKDA	OSBPL3	271	Q9H4L5
DSERVRAWQRGAFHR	PACSIN3	106	Q9UKS6
SIHRWERRRTLNKAR	RIN3	856	Q8TB24
RLRHRRSRSAGDRWV	KIF23	806	Q02241
AWAERISDLFARHRT	MMP28	101	Q9H239
AHFDQDERWSLSRRR	MMP28	216	Q9H239
NRRDSSRDGKWRSSR	RBM7	251	Q9Y580
GERWTHRFERLRLSR	SH2B1	221	Q9NRF2
TKRGHSRSRSPQWRR	SRRM2	501	Q9UQ35
WKRSRSRASPATHRR	SRRM2	1861	Q9UQ35
REVSSHAQRIARAKW	PSD	226	A5PKW4
REAEAWTRRAAASAR	SERTAD4-AS1	61	Q5TG53
WMRNRSAARRHNKAI	ABCC6	256	O95255
SWPREESNTRSRHRA	GPRASP2	246	Q96D09
SLGRRARVWRRHREA	FOXD4L5	306	Q5VV16
ARVWRRHREADASLS	FOXD4L5	311	Q5VV16
SLGRRARVWRRHREA	FOXD4L6	306	Q3SYB3
ARVWRRHREADASLS	FOXD4L6	311	Q3SYB3
HHTRRNSRWDKRTLE	SETX	2651	Q7Z333
RNSRAWHFVLSAARR	SPSB3	6	Q6PJ21
WHFVLSAARRDADAR	SPSB3	11	Q6PJ21
RSRSSSWGRNRRRSD	SRSF12	121	Q8WXF0
KEMHCGVASRWRRRR	RXRB	26	P28702
DAREAVHAWRERLSR	CHST7	426	Q9NS84
TSALWRHLRSAHRRE	ZBED3	86	Q96IU2
SSETRDTLRQWHKRR	RIN2	761	Q8WYP3
WRSRRSEERQLKHNG	TLCD5	226	Q6ZRR5
AWDAHFVDRRLRRTI	XKR6	596	Q5GH73
RVRSHSWKRNHSRAR	SRRM5	301	B3KS81
SWKRNHSRARSRTRK	SRRM5	306	B3KS81
VSWSDTRRTLRKDHR	TCERG1	916	O14776
TRRTLRKDHRWESGS	TCERG1	921	O14776
WRADSSRASLTRVHR	MRPL55	31	Q7Z7F7
RSRSRERHWDSRTRD	SNRNP35	186	Q16560
EHRTRLRWRPSRKSE	PLCH1	46	Q4KWH8
AVRWVASRRRTLHAL	ZNF862	786	O60290
QRGHSKDRTRRAWEK	ZNF786	206	Q8N393
WDQGRRSQSRRSHRS	ZRSR2P1	436	Q15695
SSSWRERCSHNRDLR	TASOR2	2066	Q5VWN6
RSRLAARFRVTAHWL	PIEZO1	181	Q92508
RSVFHIEWSSIRRRS	SLC14A2	476	Q15849
KSFSWRSRLQAHERI	ZNF45	311	Q02386
EAHRWIHRSCSERRA	ZNF785	356	A8K8V0
AHWRGALARKAIQRR	MYO1H	736	Q8N1T3
FHWKQRSSDTFRRRR	MYOF	1061	Q9NZM1
APHTTDRRARRWRRA	MYRIP	516	Q8NFW9