Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	-	HSPA4L HSPH1	2.23e-04	12	35	2	2.60.34.10
Domain	HSP70_peptide-bd	HSPA4L HSPH1	2.23e-04	12	35	2	IPR029047
Domain	-	HSPA4L HSPH1	2.63e-04	13	35	2	1.20.1270.10
Domain	Heat_shock_70_CS	HSPA4L HSPH1	2.63e-04	13	35	2	IPR018181
Domain	HSP70_C	HSPA4L HSPH1	2.63e-04	13	35	2	IPR029048
Domain	HSP70	HSPA4L HSPH1	4.03e-04	16	35	2	PF00012
Domain	HSP70_2	HSPA4L HSPH1	4.56e-04	17	35	2	PS00329
Domain	HSP70_3	HSPA4L HSPH1	4.56e-04	17	35	2	PS01036
Domain	HSP70_1	HSPA4L HSPH1	4.56e-04	17	35	2	PS00297
Domain	Hsp_70_fam	HSPA4L HSPH1	5.12e-04	18	35	2	IPR013126
Domain	-	KBTBD6 KBTBD7	3.65e-03	48	35	2	2.120.10.80
Domain	Kelch-typ_b-propeller	KBTBD6 KBTBD7	4.76e-03	55	35	2	IPR015915
Domain	Kelch	KBTBD6 KBTBD7	5.28e-03	58	35	2	SM00612
Domain	Gal_Oxase/kelch_b-propeller	KBTBD6 KBTBD7	5.46e-03	59	35	2	IPR011043
Domain	BACK	KBTBD6 KBTBD7	5.64e-03	60	35	2	SM00875
Domain	BACK	KBTBD6 KBTBD7	5.83e-03	61	35	2	PF07707
Domain	BACK	KBTBD6 KBTBD7	5.83e-03	61	35	2	IPR011705
Domain	Kelch_1	KBTBD6 KBTBD7	7.61e-03	70	35	2	PF01344
Domain	Kelch_1	KBTBD6 KBTBD7	7.61e-03	70	35	2	IPR006652
Pubmed	The KBTBD6/7-DRD2 axis regulates pituitary adenoma sensitivity to dopamine agonist treatment.	KBTBD6 KBTBD7	3.48e-06	3	38	2	32572597
Pubmed	p300-mediated acetylation stabilizes the Th-inducing POK factor.	PRPF8 HSPH1	1.74e-05	6	38	2	20810990
Pubmed	A novel HSF1-mediated death pathway that is suppressed by heat shock proteins.	HSPA4L HSPH1	2.43e-05	7	38	2	17024176
Pubmed	Regulation of Wnt/PCP signaling through p97/VCP-KBTBD7-mediated Vangl ubiquitination and endoplasmic reticulum-associated degradation.	KBTBD6 KBTBD7	2.43e-05	7	38	2	33990333
Pubmed	Genome-wide association study of the five-factor model of personality in young Korean women.	CAPZA3 PTPRD	4.16e-05	9	38	2	23903073
Pubmed	Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.	HSPA4L HSPH1	5.20e-05	10	38	2	19171884
Pubmed	CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.	KBTBD6 KBTBD7	6.35e-05	11	38	2	25684205
Pubmed	Heat-shock protein HSPA4 is required for progression of spermatogenesis.	HSPA4L HSPH1	7.62e-05	12	38	2	21487003
Pubmed	Respiratory distress and early neonatal lethality in Hspa4l/Hspa4 double-mutant mice.	HSPA4L HSPH1	7.62e-05	12	38	2	23980576
Pubmed	Gene essentiality and synthetic lethality in haploid human cells.	ANKRD11 CINP PRPF8 HSPH1	1.13e-04	229	38	4	26472760
Pubmed	Ovarian tumorB1-mediated heat shock transcription factor 1 deubiquitination is critical for glycolysis and development of endometriosis.	PRPF8 HSPA4L PDZRN3 HSPH1	1.27e-04	236	38	4	36339263
Pubmed	The CCND1 c.870G>A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma.	ANKRD11 AKAP7	1.56e-04	17	38	2	23502783
Pubmed	The diverse members of the mammalian HSP70 machine show distinct chaperone-like activities.	HSPA4L HSPH1	2.90e-04	23	38	2	21231916
Pubmed	Dimerization quality control ensures neuronal development and survival.	KBTBD6 KBTBD7	3.16e-04	24	38	2	30190310
Pubmed	Systematic Proteomic Identification of the Heat Shock Proteins (Hsp) that Interact with Estrogen Receptor Alpha (ERα) and Biochemical Characterization of the ERα-Hsp70 Interaction.	HSPA4L HSPH1	3.43e-04	25	38	2	27483141
Pubmed	Host determinants of HIV-1 control in African Americans.	CYP4V2 C3orf18	3.72e-04	26	38	2	20205591
Pubmed	Isoform-selective Genetic Inhibition of Constitutive Cytosolic Hsp70 Activity Promotes Client Tau Degradation Using an Altered Co-chaperone Complement.	HSPA4L HSPH1	4.96e-04	30	38	2	25864199
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	PRPF8 HSPA4L GCLC HSPH1	5.32e-04	344	38	4	30333137
Pubmed	Aerobic glycolysis tunes YAP/TAZ transcriptional activity.	PRPF8 HSPA4L HSPH1	7.42e-04	162	38	3	25796446
Pubmed	USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities.	CYP4V2 SENP2 STK31 PRAMEF13 PREX2	7.96e-04	674	38	5	37196079
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	PRPF8 STK31 HSPA4L GCLC ADAM7 CTAGE1 HSPH1	8.47e-04	1442	38	7	35575683
Cytoband	13q14.11	KBTBD6 KBTBD7	4.85e-04	39	38	2	13q14.11
Cytoband	Ensembl 112 genes in cytogenetic band chr8q13	PPP1R42 PREX2	1.83e-03	76	38	2	chr8q13
GeneFamily	Heat shock 70kDa proteins	HSPA4L HSPH1	2.46e-04	17	25	2	583
Disease	QRS duration	NHLH2 SENP2 CAPZA3 PTPRD PDZRN3	2.57e-05	298	35	5	EFO_0005055
Disease	benign prostatic hyperplasia	GCLC UNC13A	1.23e-04	14	35	2	EFO_0000284
Disease	Primary microcephaly	RTTN CEP63	3.11e-04	22	35	2	C0431350
Disease	personality trait	CAPZA3 PTPRD	9.85e-04	39	35	2	EFO_0004365
Disease	JT interval	SENP2 SLC27A6 FAM13B	3.15e-03	248	35	3	EFO_0007885
Disease	wellbeing measurement, alcohol consumption measurement	UNC13A PREX2	3.50e-03	74	35	2	EFO_0007869, EFO_0007878
Disease	QT interval	SENP2 SLC27A6 FAM13B PDZRN3	3.56e-03	534	35	4	EFO_0004682
Disease	response to anticonvulsant	SLC27A6 PREX2	4.59e-03	85	35	2	GO_0036277
Disease	S-warfarin measurement	PRIMA1 ADAM7	5.93e-03	97	35	2	EFO_0803323
Disease	HIV Coinfection	PRPF8 HSPH1	6.66e-03	103	35	2	C4505456
Disease	HIV Infections	PRPF8 HSPH1	6.66e-03	103	35	2	C0019693
Disease	Retinitis Pigmentosa	CYP4V2 PRPF8	6.79e-03	104	35	2	C0035334
Disease	body surface area	ANKRD11 SENP2 TBC1D21 AKAP7	6.85e-03	643	35	4	EFO_0022196
Disease	mitochondrial DNA measurement	ZNF385A CAPZA3 PDZRN3	6.85e-03	328	35	3	EFO_0006312
Disease	multiple myeloma	ANKRD11 AKAP7	7.83e-03	112	35	2	EFO_0001378
Disease	endometrial carcinoma	PTPRD CTAGE1	7.96e-03	113	35	2	EFO_1001512
Disease	conotruncal heart malformations	PTPRD TBC1D21	8.10e-03	114	35	2	MONDO_0016581
Disease	Colorectal Carcinoma	PTPRD CINP PREX2 PRIMA1	9.27e-03	702	35	4	C0009402

Protein segments in the cluster

Peptide	Gene	Start	Entry
LFAKICEKTVLKRVL	UNC13A	1361	Q9UPW8
KAKRLLYCALCKVAV	ZNF385A	196	Q96PM9
LRKTVKSKEYLIACI	CAPZA3	141	Q96KX2
YLQIRKKIEEKRKIL	ANKRD11	2441	Q6UB99
LYRKLIVEEKCRLEK	CTAGE1	366	Q96RT6
ILYRIDLCSMLKKKQ	AKAP7	256	Q9P0M2
LILLVRYRKCIKLKQ	ADAM7	686	Q9H2U9
CDIIDYLLLKKLVKE	ARL13A	141	Q5H913
LKRLILKLDIKCAYA	PDZRN3	71	Q9UPQ7
EYKKIKAKLRLLEVL	FAM13B	891	Q9NYF5
RALLRLYQECEKLKK	HSPH1	261	Q92598
VALVLYIRKKKRLEK	C3orf18	76	Q9UK00
CLDLQALLYKKIIKE	PF4V1	86	P10720
LIKCHLKLYRTKLIY	OR52A4P	166	A6NMU1
TRCSILNYLKLIKKR	GCLC	551	P48506
LLTKPIVKKYCLDVI	KBTBD7	281	Q8WVZ9
KLYKCSVDIRKIRRL	MTERF2	51	Q49AM1
CILSKRLRKGKLEYL	CBX2	16	Q14781
ELCILKRSYEKLQKK	CEP63	106	Q96MT8
ICLKILQLYARKKVD	CCNL2	276	Q96S94
KKLRYLECVIKETLR	CYP4V2	376	Q6ZWL3
KLEREYEVKRLCKLK	C4orf36	76	Q96KX1
LLTKPIVKKYCLDVI	KBTBD6	281	Q86V97
IRKLRCYLKEMKTLG	PRAMEF13	221	Q5VWM6
ICIVIAILLYKRKRA	PTPRD	1281	P23468
AVVKKLCLIDKIIEY	RTTN	866	Q86VV8
LVVIDLRKKCLKYLD	SENP2	481	Q9HC62
DKKRLEKILLLSYVC	TBC1D21	141	Q8IYX1
VIICYKAIKRKPLRK	PRIMA1	111	Q86XR5
CIENLRSLKKLEKLY	PPP1R42	86	Q7Z4L9
KKLSKIEILRLAICY	NHLH2	111	Q02577
KLLEMYRKELLLKRT	CINP	151	Q9BW66
YLCLIFKVKKRSILI	CMKLR2	226	P46091
VCKKNLGRLTRLYLK	PRPF8	771	Q6P2Q9
YRCKVLKIISVEKCL	STK31	96	Q9BXU1
RALLRLYQECEKLKK	HSPA4L	261	O95757
QRICKYPLILKELLK	PREX2	171	Q70Z35
KVVLIIIRLKKYEKR	SLC27A6	36	Q9Y2P4