Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	Oest-rel_rcp	ESRRB ESRRG	1.86e-05	3	47	2	IPR027289
Domain	Oest_rcpt/oest-rel_rcp	ESRRB ESRRG	6.17e-05	5	47	2	IPR024178
Domain	Adcy_conserved_dom	ADCY2 ADCY7	9.24e-05	6	47	2	IPR009398
Domain	DUF1053	ADCY2 ADCY7	9.24e-05	6	47	2	PF06327
Domain	AC_N	ADCY2 ADCY7	1.72e-04	8	47	2	IPR032628
Domain	Adcy	ADCY2 ADCY7	1.72e-04	8	47	2	IPR030672
Domain	AC_N	ADCY2 ADCY7	1.72e-04	8	47	2	PF16214
Domain	Retinoid-X_rcpt/HNF4	ESRRB ESRRG	2.75e-04	10	47	2	IPR000003
Domain	-	GATAD2A ESRRB ESRRG	3.97e-04	57	47	3	3.30.50.10
Domain	Znf_NHR/GATA	GATAD2A ESRRB ESRRG	4.18e-04	58	47	3	IPR013088
Domain	A/G_cyclase_CS	ADCY2 ADCY7	8.23e-04	17	47	2	IPR018297
Domain	Chromodomain_CS	CHD1 CHD3	9.24e-04	18	47	2	IPR023779
Domain	Nucleotide_cyclase	ADCY2 ADCY7	9.24e-04	18	47	2	IPR029787
Domain	-	ADCY2 ADCY7	9.24e-04	18	47	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	ADCY2 ADCY7	1.03e-03	19	47	2	PS00452
Domain	Guanylate_cyc	ADCY2 ADCY7	1.03e-03	19	47	2	PF00211
Domain	GUANYLATE_CYCLASE_2	ADCY2 ADCY7	1.03e-03	19	47	2	PS50125
Domain	A/G_cyclase	ADCY2 ADCY7	1.03e-03	19	47	2	IPR001054
Domain	CYCc	ADCY2 ADCY7	1.03e-03	19	47	2	SM00044
Domain	Chromo_domain	CHD1 CHD3	1.65e-03	24	47	2	IPR023780
Domain	Chromo	CHD1 CHD3	1.94e-03	26	47	2	PF00385
Domain	HECT	UBE3B HERC5	2.09e-03	27	47	2	PF00632
Domain	HECTc	UBE3B HERC5	2.09e-03	27	47	2	SM00119
Domain	HECT_dom	UBE3B HERC5	2.09e-03	27	47	2	IPR000569
Domain	HECT	UBE3B HERC5	2.09e-03	27	47	2	PS50237
Domain	CHROMO_1	CHD1 CHD3	2.25e-03	28	47	2	PS00598
Domain	CHROMO_2	CHD1 CHD3	2.25e-03	28	47	2	PS50013
Domain	SNF2_N	CHD1 CHD3	2.93e-03	32	47	2	IPR000330
Domain	Chromodomain-like	CHD1 CHD3	2.93e-03	32	47	2	IPR016197
Domain	SNF2_N	CHD1 CHD3	2.93e-03	32	47	2	PF00176
Domain	Chromo/shadow_dom	CHD1 CHD3	3.11e-03	33	47	2	IPR000953
Domain	CHROMO	CHD1 CHD3	3.11e-03	33	47	2	SM00298
Domain	DNA/RNA_helicase_DEAH_CS	CHD1 CHD3	3.50e-03	35	47	2	IPR002464
Domain	DEAH_ATP_HELICASE	CHD1 CHD3	4.11e-03	38	47	2	PS00690
Domain	zf-C4	ESRRB ESRRG	5.98e-03	46	47	2	PF00105
Domain	Znf_hrmn_rcpt	ESRRB ESRRG	5.98e-03	46	47	2	IPR001628
Domain	Nuclear_hrmn_rcpt	ESRRB ESRRG	5.98e-03	46	47	2	IPR001723
Domain	NUCLEAR_REC_DBD_2	ESRRB ESRRG	5.98e-03	46	47	2	PS51030
Domain	NUCLEAR_REC_DBD_1	ESRRB ESRRG	5.98e-03	46	47	2	PS00031
Domain	ZnF_C4	ESRRB ESRRG	5.98e-03	46	47	2	SM00399
Domain	-	ESRRB ESRRG	6.23e-03	47	47	2	1.10.565.10
Domain	HOLI	ESRRB ESRRG	6.49e-03	48	47	2	SM00430
Domain	Nucl_hrmn_rcpt_lig-bd	ESRRB ESRRG	6.49e-03	48	47	2	IPR000536
Domain	Hormone_recep	ESRRB ESRRG	6.49e-03	48	47	2	PF00104
Pathway	WP_TYPE_III_INTERFERON_SIGNALING	JAK1 IFNLR1	2.98e-04	10	37	2	M39464
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY2 ADCY7	2.98e-04	10	37	2	M19522
Pathway	REACTOME_ADENYLATE_CYCLASE_ACTIVATING_PATHWAY	ADCY2 ADCY7	2.98e-04	10	37	2	MM14668
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY2 ADCY7	5.98e-04	14	37	2	MM14669
Pathway	REACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY	ADCY2 ADCY7	5.98e-04	14	37	2	M750
Pathway	KEGG_MEDICUS_REFERENCE_EP_NE_ADRB_CAMP_SIGNALING_PATHWAY	ADCY2 ADCY7	6.89e-04	15	37	2	M47794
Pathway	PID_LPA4_PATHWAY	ADCY2 ADCY7	6.89e-04	15	37	2	M56
Pathway	KEGG_MEDICUS_REFERENCE_PTH_PTH1R_PKA_SIGNALING_PATHWAY	ADCY2 ADCY7	6.89e-04	15	37	2	M47504
Pathway	WP_MAJOR_RECEPTORS_TARGETED_BY_EPINEPHRINE_AND_NOREPINEPHRINE	ADCY2 ADCY7	7.86e-04	16	37	2	M39849
Pathway	KEGG_MEDICUS_REFERENCE_LHCGR_GNAS_PKA_SIGNALING_PATHWAY	ADCY2 ADCY7	7.86e-04	16	37	2	M47645
Pathway	KEGG_MEDICUS_REFERENCE_FSHR_GNAS_PKA_SIGNALING_PATHWAY	ADCY2 ADCY7	7.86e-04	16	37	2	M47650
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY2 ADCY7	7.86e-04	16	37	2	MM14492
Pathway	REACTOME_PKA_ACTIVATION_IN_GLUCAGON_SIGNALLING	ADCY2 ADCY7	8.89e-04	17	37	2	M26995
Pathway	KEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY2 ADCY7	8.89e-04	17	37	2	M47544
Pathway	REACTOME_PKA_MEDIATED_PHOSPHORYLATION_OF_CREB	ADCY2 ADCY7	1.24e-03	20	37	2	M759
Pathway	REACTOME_OTHER_INTERLEUKIN_SIGNALING	JAK1 IFNLR1	1.78e-03	24	37	2	M27385
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY2 ADCY7	1.78e-03	24	37	2	M47520
Pathway	REACTOME_INTERLEUKIN_20_FAMILY_SIGNALING	JAK1 IFNLR1	2.09e-03	26	37	2	M27750
Pathway	KEGG_MEDICUS_PATHOGEN_HCMV_UL33_TO_GNAI_AC_PKA_SIGNALING_PATHWAY	ADCY2 ADCY7	2.09e-03	26	37	2	M47553
Pathway	REACTOME_CA_DEPENDENT_EVENTS	ADCY2 ADCY7	2.09e-03	26	37	2	MM14495
Pathway	REACTOME_FGFR2_ALTERNATIVE_SPLICING	NCBP2 TIA1	2.26e-03	27	37	2	M27632
Pathway	REACTOME_REGULATION_OF_PTEN_GENE_TRANSCRIPTION	CHD3 GATAD2A	2.26e-03	27	37	2	MM15537
Pathway	KEGG_MEDICUS_REFERENCE_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY2 ADCY7	2.26e-03	27	37	2	M47518
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_RASD1_TO_CRHR_PKA_ACTH_SIGNALING_PATHWAY	ADCY2 ADCY7	2.26e-03	27	37	2	M47519
Pathway	KEGG_MELANOGENESIS	FZD10 ADCY2 ADCY7	2.32e-03	101	37	3	M7761
Pathway	KEGG_GNRH_SIGNALING_PATHWAY	PLA2G12B ADCY2 ADCY7	2.32e-03	101	37	3	M1979
Pathway	KEGG_MEDICUS_REFERENCE_GHRHR_PKA_GH_SIGNALING_PATHWAY	ADCY2 ADCY7	2.43e-03	28	37	2	M47647
Pathway	REACTOME_HEDGEHOG_OFF_STATE	WDR35 ADCY2 ADCY7	2.60e-03	105	37	3	MM15206
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_GNAS_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY2 ADCY7	2.60e-03	29	37	2	M47515
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	CHD3 GATAD2A	2.60e-03	29	37	2	MM15340
Pathway	KEGG_MEDICUS_REFERENCE_TSH_TG_SIGNALING_PATHWAY	ADCY2 ADCY7	2.60e-03	29	37	2	M47627
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_ACETYLATION	CHD3 GATAD2A	2.78e-03	30	37	2	M27637
Pathway	REACTOME_TRANSCRIPTIONAL_REGULATION_OF_BROWN_AND_BEIGE_ADIPOCYTE_DIFFERENTIATION	CHD3 GATAD2A	2.97e-03	31	37	2	M48258
Pathway	KEGG_MEDICUS_VARIANT_CYP11B1_CYP11B2_FUSION_TO_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY2 ADCY7	2.97e-03	31	37	2	M47507
Pathway	KEGG_MEDICUS_REFERENCE_ACTH_CORTISOL_SIGNALING_PATHWAY	ADCY2 ADCY7	3.16e-03	32	37	2	M47506
Pathway	REACTOME_HEDGEHOG_OFF_STATE	WDR35 ADCY2 ADCY7	3.20e-03	113	37	3	M27471
Pathway	KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION	PLA2G12B ADCY2 ADCY7	3.36e-03	115	37	3	M9387
Pathway	REACTOME_G_ALPHA_Z_SIGNALLING_EVENTS	ADCY2 ADCY7	3.36e-03	33	37	2	MM15058
Pathway	REACTOME_GLUCAGON_SIGNALING_IN_METABOLIC_REGULATION	ADCY2 ADCY7	3.36e-03	33	37	2	M11575
Pubmed	Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR.	ESRRB ESRRG	1.87e-06	2	48	2	10072763
Pubmed	Expression of estrogen-related receptors in ovarian cancer and impact on survival.	ESRRB ESRRG	1.87e-06	2	48	2	34089362
Pubmed	An ERRbeta/gamma agonist modulates GRalpha expression, and glucocorticoid responsive gene expression in skeletal muscle cells.	ESRRB ESRRG	1.87e-06	2	48	2	19631715
Pubmed	Crystal Structure of a Complex of the Intracellular Domain of Interferon λ Receptor 1 (IFNLR1) and the FERM/SH2 Domains of Human JAK1.	JAK1 IFNLR1	1.87e-06	2	48	2	27725180
Pubmed	Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B.	PLA2G12B ESRRG	1.87e-06	2	48	2	30922124
Pubmed	Expression and functional study of estrogen receptor-related receptors in human prostatic cells and tissues.	ESRRB ESRRG	5.59e-06	3	48	2	15598686
Pubmed	Estrogen-Related Receptors Mediate the Adaptive Response of Brown Adipose Tissue to Adrenergic Stimulation.	ESRRB ESRRG	5.59e-06	3	48	2	29888756
Pubmed	The Structural Basis for Class II Cytokine Receptor Recognition by JAK1.	JAK1 IFNLR1	5.59e-06	3	48	2	27133025
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	JAK1 PDS5A SEPHS1 CHD1 ZZEF1	1.11e-05	212	48	5	33853758
Pubmed	Characterization of the CHD family of proteins.	CHD1 CHD3	1.12e-05	4	48	2	9326634
Pubmed	Target specificities of estrogen receptor-related receptors: analysis of binding sequences and identification of Rb1-inducible coiled-coil 1 (Rb1cc1) as a target gene.	ESRRB ESRRG	1.12e-05	4	48	2	18039682
Pubmed	Estrogen-related receptors alpha, beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma.	ESRRB ESRRG	1.12e-05	4	48	2	29940916
Pubmed	Involvement of estrogen-related receptors in transcriptional response to hypoxia and growth of solid tumors.	ESRRB ESRRG	1.86e-05	5	48	2	18509053
Pubmed	Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.	ESRRB ESRRG	1.86e-05	5	48	2	23676496
Pubmed	Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases.	ESRRB ESRRG	2.79e-05	6	48	2	21177257
Pubmed	Receptor-interacting protein 140 differentially regulates estrogen receptor-related receptor transactivation depending on target genes.	ESRRB ESRRG	2.79e-05	6	48	2	16439465
Pubmed	Peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells.	ESRRB ESRRG	2.79e-05	6	48	2	23836911
Pubmed	Coexistence within one cell of microvillous and ciliary phototransductions across M1- through M6-IpRGCs.	ADCY2 ADCY7	3.90e-05	7	48	2	38109525
Pubmed	Mammalian chromodomain proteins: their role in genome organisation and expression.	CHD1 CHD3	5.19e-05	8	48	2	10655032
Pubmed	A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.	LMO1 ESRRG	5.19e-05	8	48	2	23743675
Pubmed	Role of the calcium modulated cyclases in the development of the retinal projections.	ADCY2 ADCY7	6.67e-05	9	48	2	17229090
Pubmed	A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.	CHD1 CHD3	6.67e-05	9	48	2	16728976
Pubmed	Perm1 promotes cardiomyocyte mitochondrial biogenesis and protects against hypoxia/reoxygenation-induced damage in mice.	ESRRB ESRRG	6.67e-05	9	48	2	34029594
Pubmed	Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS.	ADCY2 ADCY7	6.67e-05	9	48	2	9417641
Pubmed	Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.	ADCY2 ADCY7	6.67e-05	9	48	2	12503609
Pubmed	Purification and characterization of a soluble form of mammalian adenylyl cyclase.	ADCY2 ADCY7	8.33e-05	10	48	2	8663304
Pubmed	Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons.	ADCY2 ADCY7	8.33e-05	10	48	2	11884542
Pubmed	Comprehensive analysis of the expression patterns of the adenylate cyclase gene family in the developing and adult mouse brain.	ADCY2 ADCY7	8.33e-05	10	48	2	16615126
Pubmed	Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1.	ADCY2 ADCY7	1.02e-04	11	48	2	10089566
Pubmed	gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression.	ADCY2 ADCY7	1.02e-04	11	48	2	10808179
Pubmed	Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures.	ADCY2 ADCY7	1.02e-04	11	48	2	11299302
Pubmed	Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.	JAK1 PDS5A CHD1 CHD3 SRBD1	1.07e-04	341	48	5	32971831
Pubmed	ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control.	ESRRB ESRRG	1.22e-04	12	48	2	36542664
Pubmed	NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.	CHD3 GATAD2A	1.22e-04	12	48	2	22560079
Pubmed	Expression of adenylyl cyclase mRNAs in the denervated and in the developing mouse skeletal muscle.	ADCY2 ADCY7	1.22e-04	12	48	2	9611134
Pubmed	HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones.	ADCY2 ADCY7	1.22e-04	12	48	2	10807185
Pubmed	A multi-centre study of candidate genes for wheeze and allergy: the International Study of Asthma and Allergies in Childhood Phase 2.	SETDB2 SPINK5	1.68e-04	14	48	2	20085599
Pubmed	MBD2/NuRD and MBD3/NuRD, two distinct complexes with different biochemical and functional properties.	CHD3 GATAD2A	1.68e-04	14	48	2	16428440
Pubmed	Isoforms of mammalian adenylyl cyclase: multiplicities of signaling.	ADCY2 ADCY7	1.68e-04	14	48	2	14993377
Pubmed	NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.	CHD3 GATAD2A	1.68e-04	14	48	2	25150861
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PDS5A SETDB2 CHD1 CHD3 SRBD1 GATAD2A	1.83e-04	608	48	6	36089195
Pubmed	Quantitative trait loci affecting initial sensitivity and acute functional tolerance to ethanol-induced ataxia and brain cAMP signaling in BXD recombinant inbred mice.	CD53 ADCY7	1.94e-04	15	48	2	12183685
Pubmed	Mechanism of GTP hydrolysis by G-protein alpha subunits.	ADCY2 ADCY7	1.94e-04	15	48	2	7937899
Pubmed	DLX1 and the NuRD complex cooperate in enhancer decommissioning and transcriptional repression.	CHD3 GATAD2A	1.94e-04	15	48	2	35695185
Pubmed	cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes.	ADCY2 ADCY7	1.94e-04	15	48	2	2165385
Pubmed	NuRD mediates activating and repressive functions of GATA-1 and FOG-1 during blood development.	CHD3 GATAD2A	1.94e-04	15	48	2	19927129
Pubmed	Molecular characterization of the ankle-link complex in cochlear hair cells and its role in the hair bundle functioning.	ADCY2 ADCY7	2.21e-04	16	48	2	17567809
Pubmed	Esrrb function is required for proper primordial germ cell development in presomite stage mouse embryos.	ESRRB DPPA2	2.50e-04	17	48	2	31315026
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	CHD1 CHD3 GATAD2A	2.75e-04	91	48	3	20362542
Pubmed	Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.	CHD3 GATAD2A	2.81e-04	18	48	2	10444591
Pubmed	SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progression.	CHD3 GATAD2A	2.81e-04	18	48	2	29996942
Pubmed	The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.	CHD3 GATAD2A	2.81e-04	18	48	2	9790534
Pubmed	Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.	ADCY2 ESRRG	4.23e-04	22	48	2	24376456
Pubmed	Cartilage-specific overexpression of ERRγ results in Chondrodysplasia and reduced chondrocyte proliferation.	ESRRB ESRRG	4.63e-04	23	48	2	24349082
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	NCBP2 PDS5A CHD1 CHD3 GATAD2A	4.64e-04	469	48	5	27634302
Pubmed	Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells.	GATAD2A ESRRB	5.05e-04	24	48	2	18454139
Pubmed	Decoding type I and III interferon signalling during viral infection.	JAK1 IFNLR1	6.40e-04	27	48	2	30936491
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	SEPHS1 CHD3 STOX1 SRBD1 RNF17 PCDHGA12 ZNF541 DPPA2	7.37e-04	1442	48	8	35575683
Pubmed	Specification of dopaminergic subsets involves interplay of En1 and Pitx3.	TIA1 SCN3B	8.45e-04	31	48	2	23863478
Pubmed	Glucagon and regulation of glucose metabolism.	ADCY2 ADCY7	8.45e-04	31	48	2	12626323
Pubmed	TBX1 is required for normal stria vascularis and semicircular canal development.	FBN1 ESRRB	8.45e-04	31	48	2	31550482
Pubmed	Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.	OPN1SW ESRRB	9.01e-04	32	48	2	25757744
Pubmed	A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene.	JAK1 GATAD2A ZMAT1 UBE3B	1.13e-03	331	48	4	19490893
Pubmed	Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.	CHD3 GATAD2A	1.27e-03	38	48	2	28680062
Pubmed	Cross-linking mass spectrometry reveals the structural topology of peripheral NuRD subunits relative to the core complex.	CHD3 GATAD2A	1.27e-03	38	48	2	33283408
Pubmed	Direct reprogramming of fibroblasts into renal tubular epithelial cells by defined transcription factors.	ESRRB ESRRG	1.27e-03	38	48	2	27820600
Cytoband	10q22.1	STOX1 PLA2G12B	1.08e-03	46	48	2	10q22.1
GeneFamily	Adenylate cyclases\|Deafness associated genes	ADCY2 ADCY7	1.53e-04	10	34	2	53
GeneFamily	Nuclear hormone receptors	ESRRB ESRRG	3.82e-03	49	34	2	71
Drug	clenbuterol	ADCY2 ADCY7 ESRRB ESRRG SCN3B MYO5C	5.24e-07	142	48	6	CID000002783
Drug	Ganciclovir [82410-32-0]; Up 200; 15.6uM; HL60; HT_HG-U133A	FZD10 RSPH14 MSH4 GFPT2 RNF17 ZZEF1	3.85e-06	200	48	6	3030_UP
Drug	Fenoprofen calcium salt dihydrate [53746-45-5]; Up 200; 7.2uM; PC3; HT_HG-U133A	CD53 FZD10 RSPH14 RNF17 ZZEF1 SPINK5	3.85e-06	200	48	6	3714_UP
Drug	N'-((1E)-(4-(diethylamino)phenyl)methylene)-4-hydroxybenzohydrazide	ESRRB ESRRG	4.35e-06	2	48	2	ctd:C501618
Disease	Prostatic Neoplasms	JAK1 PDS5A UNC13D CHD1 CHD3 SPINK5	4.71e-04	616	48	6	C0033578
Disease	Malignant neoplasm of prostate	JAK1 PDS5A UNC13D CHD1 CHD3 SPINK5	4.71e-04	616	48	6	C0376358
Disease	neutrophil percentage of granulocytes	JAK1 CHD1 ASB2 ZNF652	5.17e-04	228	48	4	EFO_0007994
Disease	eosinophil percentage of granulocytes	JAK1 CHD1 ASB2 ZNF652	5.70e-04	234	48	4	EFO_0007996
Disease	azoospermia (implicated_via_orthology)	ESRRB ESRRG	8.86e-04	27	48	2	DOID:14227 (implicated_via_orthology)
Disease	liver cirrhosis (biomarker_via_orthology)	WDR35 FBN1	1.41e-03	34	48	2	DOID:5082 (biomarker_via_orthology)
Disease	dyslexia	SETDB2 GATAD2A ESRRG	2.34e-03	162	48	3	EFO_0005424
Disease	attempted suicide	SEPHS1 ARL5B FBN1	3.06e-03	178	48	3	EFO_0004321
Disease	executive function measurement	GFPT2 ESRRG MYO5C DPPA2	3.25e-03	376	48	4	EFO_0009332

Protein segments in the cluster

Peptide	Gene	Start	Entry
CMGSIKENKCLLMSF	CD53	71	P19397
FKICMKMCLLQITGY	ELMOD2	91	Q8IZ81
LIFANKQDMKGCMTA	ARL5B	121	Q96KC2
MKCLSLLKFLMDLGC	ASB2	486	Q96Q27
NCVKMGLDMCQAIKQ	ADCY7	346	P51828
SGFLNIMMELKKCCN	CHD1	746	O14646
NCSAMFGKLMTIAKN	PDS5A	531	Q29RF7
MCKKCMELISLPLAN	RBSN	186	Q9H1K0
IKEDCNAMAFCAKMR	JAK1	6	P23458
CMGAIKCQLNLDILM	PCDHGA12	96	O60330
GDKFFLKNNMILCQM	LMO1	126	P25800
IMCENCMTTNQKKAL	GATAD2A	436	Q86YP4
MGLDKMKKTACGFCF	NCBP2	71	P52298
GTKELLCSMMCLKKQ	IFNLR1	76	Q8IU57
LCSMMCLKKQDLYNK	IFNLR1	81	Q8IU57
GIMFINKCATCKMIL	SPINK5	56	Q9NQ38
KMHINKCAMCQSIFD	SPINK5	876	Q9NQ38
CLLMPQCNAFLSKIM	KIAA2026	331	Q5HYC2
MAGKSMQLLKNLQCA	TUBGCP5	561	Q96RT8
MDLGIPAMTKCCNQL	PLA2G12B	101	Q9BX93
QMKDLNNMKITFCCP	HERC5	966	Q9UII4
CKMNNQTKTLDCLMA	FZD10	481	Q9ULW2
KNCVKMGLDMCEAIK	ADCY2	356	Q08462
QKMAQENMCCDKSGF	CCDC125	251	Q86Z20
IMVIMKDPCFAKCQN	GFPT2	591	O94808
CDGELLFNMTKKMCC	FBN1	1706	P35555
LFNMTKKMCCCSYNI	FBN1	1711	P35555
KQMECKNLIGTYMCI	FBN1	2261	P35555
VSLLNIMMDLKKCCN	CHD3	1016	Q12873
QACRFMKCLKVGMLK	ESRRG	181	P62508
QACRFMKCLKVGMLK	ESRRB	156	O95718
NMLCPDCAKRNKKMM	DPPA2	276	Q7Z7J5
MNKQFQACIMKMVCG	OPN1SW	306	P03999
LAKMAAVSKACGNMF	SEPHS1	296	P49903
MKGCLNMRTQKCYAV	MSH4	476	O15457
MSECLLKAMLNCKTF	SRBD1	291	Q8N5C6
KRSCALQMKYCQAFM	CLEC9A	86	Q6UXN8
NCSEIICMFNNMGKI	RNF17	291	Q9BXT8
KKKEMLQMVCAQCHG	ZFAND2A	106	Q8N6M9
DCSGACLMKMPLNLK	SETDB2	146	Q96T68
YKAMNIGCMENLKAL	RSPH14	61	Q9UHP6
LQNDGKCCPFMESML	STOX1	591	Q6ZVD7
VQGNPMKLRCISCMK	SCN3B	36	Q9NY72
ECSKMFPKLTKNMLC	PRSS55	221	Q6UWB4
ESKQLLAMLMLFCDC	UBE3B	521	Q7Z3V4
RSQCMQLVGDCLMKA	ZZEF1	1936	O43149
QGNFMIKMKLSCLVN	WDR35	186	Q9P2L0
KQFMCQWCGKDFNMK	ZNF652	411	Q9Y2D9
VQMCKMKAFGELCPN	UNC13D	436	Q70J99
LFSQIGPCKNCKMIM	TIA1	26	P31483
GFRKEKAKMDMCCAA	ZNF541	756	Q9H0D2
GVDKNKFCDLCNMMF	ZMAT1	116	Q5H9K5
LFLRKDMCSCRKGMQ	MYO5C	1591	Q9NQX4