Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	4.06e-07	343	90	11	GO:0005261
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	6.82e-06	459	90	11	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 KCNS1 CNGB1	7.71e-06	465	90	11	GO:0046873
GeneOntologyMolecularFunction	channel activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	2.38e-05	525	90	11	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	2.43e-05	526	90	11	GO:0022803
GeneOntologyMolecularFunction	calcium channel activity	CACNA1C CACNA1E CACNA1F TRPC4AP PKD1 CNGB1	2.58e-05	129	90	6	GO:0005262
GeneOntologyMolecularFunction	high voltage-gated calcium channel activity	CACNA1C CACNA1E CACNA1F	3.11e-05	14	90	3	GO:0008331
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 KCNS1 CNGB1 UNC80	4.23e-05	664	90	12	GO:0008324
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1C CACNA1E CACNA1F TRPC4AP PKD1 CNGB1	6.25e-05	151	90	6	GO:0015085
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1C CACNA1E CACNA1F KCNB1 KCNV2 KCNS1	6.48e-05	152	90	6	GO:0022843
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 ABCA6 KCNV2 PKD1 SLC4A10 ABCB11 KCNS1 CNGB1 SLC16A12 UNC80 SLC2A5	6.80e-05	1180	90	16	GO:0022857
GeneOntologyMolecularFunction	small GTPase binding	RANBP1 RANBP2 MYO5B INF2 PLEKHG2 XPO1 GDI2 PLCE1	1.01e-04	321	90	8	GO:0031267
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 KCNS1 CNGB1	1.18e-04	627	90	11	GO:0022890
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	CACNA1C CACNA1E CACNA1F KCNB1 KCNV2 KCNS1	1.74e-04	182	90	6	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	CACNA1C CACNA1E CACNA1F KCNB1 KCNV2 KCNS1	1.85e-04	184	90	6	GO:0022832
GeneOntologyMolecularFunction	transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 ABCA6 KCNV2 PKD1 SLC4A10 ABCB11 KCNS1 CNGB1 SLC16A12 UNC80 SLC2A5	1.90e-04	1289	90	16	GO:0005215
GeneOntologyMolecularFunction	GTPase binding	RANBP1 RANBP2 MYO5B INF2 PLEKHG2 XPO1 GDI2 PLCE1	2.21e-04	360	90	8	GO:0051020
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 KCNS1 CNGB1 UNC80	2.26e-04	793	90	12	GO:0015075
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 KCNS1 CNGB1	5.95e-04	758	90	11	GO:0015318
GeneOntologyMolecularFunction	gated channel activity	CACNA1C CACNA1E CACNA1F KCNB1 KCNV2 KCNS1 CNGB1	7.84e-04	334	90	7	GO:0022836
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1C CACNA1E CACNA1F	1.17e-03	46	90	3	GO:0005245
GeneOntologyMolecularFunction	GDP-dissociation inhibitor activity	RANBP1 GDI2	2.61e-03	17	90	2	GO:0005092
GeneOntologyBiologicalProcess	calcium ion transmembrane transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP PKD1 NIPSNAP2 PLCH1 CNGB1 PLCE1	1.10e-06	392	90	11	GO:0070588
GeneOntologyBiologicalProcess	calcium ion transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A IL16 TRPC4AP PKD1 NIPSNAP2 PLCH1 CNGB1 PLCE1	2.14e-06	509	90	12	GO:0006816
GeneOntologyBiologicalProcess	monoatomic cation transmembrane transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 NIPSNAP2 KCNS1 PLCH1 CNGB1 UNC80 PLCE1	2.82e-06	942	90	16	GO:0098655
GeneOntologyBiologicalProcess	metal ion transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A IL16 TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 NIPSNAP2 KCNS1 PLCH1 CNGB1 PLCE1	6.04e-06	1000	90	16	GO:0030001
GeneOntologyBiologicalProcess	monoatomic cation transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A IL16 TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 NIPSNAP2 KCNS1 PLCH1 CNGB1 UNC80 PLCE1	9.16e-06	1157	90	17	GO:0006812
GeneOntologyBiologicalProcess	inorganic cation transmembrane transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 NIPSNAP2 KCNS1 PLCH1 CNGB1 PLCE1	1.01e-05	922	90	15	GO:0098662
GeneOntologyBiologicalProcess	monoatomic ion transmembrane transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 NIPSNAP2 KCNS1 PLCH1 CNGB1 UNC80 PLCE1	2.34e-05	1115	90	16	GO:0034220
GeneOntologyBiologicalProcess	inorganic ion transmembrane transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 NIPSNAP2 KCNS1 PLCH1 CNGB1 PLCE1	3.18e-05	1017	90	15	GO:0098660
GeneOntologyBiologicalProcess	organelle localization	STX19 SCN11A KAT5 KCNB1 MYO5B ATCAY PKD1 ASPM SPO11 ATM XPO1 SDAD1	5.38e-05	703	90	12	GO:0051640
GeneOntologyBiologicalProcess	monoatomic ion transport	JPH1 CACNA1C CACNA1E CACNA1F SCN11A IL16 TRPC4AP KCNB1 KCNV2 PKD1 SLC4A10 NIPSNAP2 KCNS1 PLCH1 CNGB1 UNC80 PLCE1	8.13e-05	1374	90	17	GO:0006811
GeneOntologyBiologicalProcess	regulation of DNA stability	DDIAS RTF2	1.12e-04	4	90	2	GO:0097752
GeneOntologyBiologicalProcess	signal transduction in response to DNA damage	KAT5 TELO2 HIPK2 ZNF830 CHEK1 ATM	2.44e-04	200	90	6	GO:0042770
GeneOntologyCellularComponent	cation channel complex	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	6.23e-08	235	89	10	GO:0034703
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	4.74e-06	378	89	10	GO:0034702
GeneOntologyCellularComponent	transmembrane transporter complex	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	7.64e-05	523	89	10	GO:1902495
GeneOntologyCellularComponent	transporter complex	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 PKD1 KCNS1 CNGB1 UNC80	1.16e-04	550	89	10	GO:1990351
GeneOntologyCellularComponent	calcium channel complex	CACNA1C CACNA1E CACNA1F PKD1	2.67e-04	73	89	4	GO:0034704
GeneOntologyCellularComponent	microtubule minus-end	ASPM CAMSAP2	3.71e-04	7	89	2	GO:0036449
GeneOntologyCellularComponent	perikaryon	CACNA1C CACNA1E CACNA1F DRP2 KCNB1 SLC4A10	3.83e-04	223	89	6	GO:0043204
GeneOntologyCellularComponent	chromosomal region	KAT5 TELO2 CENPH SPO11 MCM5 CHEK1 ATM XPO1	4.31e-04	421	89	8	GO:0098687
GeneOntologyCellularComponent	chromosome, telomeric region	TELO2 SPO11 MCM5 CHEK1 ATM	9.37e-04	176	89	5	GO:0000781
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CACNA1C CACNA1E CACNA1F	9.92e-04	46	89	3	GO:0005891
GeneOntologyCellularComponent	annulate lamellae	RANBP2 XPO1	1.58e-03	14	89	2	GO:0005642
Domain	Channel_four-helix_dom	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 KCNS1	9.56e-09	57	89	7	IPR027359
Domain	-	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 KCNS1	9.56e-09	57	89	7	1.20.120.350
Domain	Ion_trans_dom	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 KCNS1 CNGB1	7.04e-08	114	89	8	IPR005821
Domain	Ion_trans	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 KCNS1 CNGB1	7.04e-08	114	89	8	PF00520
Domain	VDCC_a1su_IQ	CACNA1C CACNA1E CACNA1F	3.61e-06	7	89	3	IPR014873
Domain	GPHH	CACNA1C CACNA1E CACNA1F	3.61e-06	7	89	3	PF16905
Domain	GPHH_dom	CACNA1C CACNA1E CACNA1F	3.61e-06	7	89	3	IPR031649
Domain	Ca_chan_IQ	CACNA1C CACNA1E CACNA1F	3.61e-06	7	89	3	SM01062
Domain	Ca_chan_IQ	CACNA1C CACNA1E CACNA1F	3.61e-06	7	89	3	PF08763
Domain	ARM-type_fold	VAC14 TRPC4AP TELO2 INF2 IQCB1 ASPM INTS4 ATM XPO1 SDAD1	4.85e-06	339	89	10	IPR016024
Domain	VDCCAlpha1	CACNA1C CACNA1E CACNA1F	1.23e-05	10	89	3	IPR002077
Domain	CABLES1/2	CABLES2 CABLES1	2.25e-05	2	89	2	IPR012388
Domain	CAC1F_C	CACNA1C CACNA1F	6.72e-05	3	89	2	IPR031688
Domain	CAC1F_C	CACNA1C CACNA1F	6.72e-05	3	89	2	PF16885
Domain	VDCC_L_a1su	CACNA1C CACNA1F	1.34e-04	4	89	2	IPR005446
Domain	MOZ_SAS	KAT5 KAT6B	2.22e-04	5	89	2	PF01853
Domain	HAT_MYST-type	KAT5 KAT6B	2.22e-04	5	89	2	IPR002717
Domain	MYST_HAT	KAT5 KAT6B	2.22e-04	5	89	2	PS51726
Domain	K_chnl_volt-dep_Kv	KCNB1 KCNV2 KCNS1	2.82e-04	27	89	3	IPR003968
Domain	ARM-like	VAC14 TELO2 IQCB1 ASPM INTS4 XPO1 THAP11	3.06e-04	270	89	7	IPR011989
Domain	K_chnl_volt-dep_Kv9	KCNV2 KCNS1	4.64e-04	7	89	2	IPR003971
Domain	CAMSAP_CH	ASPM CAMSAP2	4.64e-04	7	89	2	PF11971
Domain	CAMSAP_CH	ASPM CAMSAP2	4.64e-04	7	89	2	IPR022613
Domain	VG_K_chnl	KCNB1 KCNV2 KCNS1	5.15e-04	33	89	3	IPR028325
Domain	Ran_BP1	RANBP1 RANBP2	1.44e-03	12	89	2	PF00638
Domain	RANBD1	RANBP1 RANBP2	1.44e-03	12	89	2	PS50196
Domain	RanBD	RANBP1 RANBP2	1.69e-03	13	89	2	SM00160
Domain	Ran_bind_dom	RANBP1 RANBP2	1.69e-03	13	89	2	IPR000156
Domain	BTB_2	KCNB1 KCNV2 KCNS1	2.06e-03	53	89	3	PF02214
Domain	T1-type_BTB	KCNB1 KCNV2 KCNS1	2.06e-03	53	89	3	IPR003131
Domain	PLipase_C_Pinositol-sp_Y	PLCH1 PLCE1	2.26e-03	15	89	2	IPR001711
Domain	EF-hand_like	PLCH1 PLCE1	2.26e-03	15	89	2	PF09279
Domain	PIPLC_Y_DOMAIN	PLCH1 PLCE1	2.26e-03	15	89	2	PS50008
Domain	PI-PLC_fam	PLCH1 PLCE1	2.26e-03	15	89	2	IPR001192
Domain	PLC_EF-hand-like	PLCH1 PLCE1	2.26e-03	15	89	2	IPR015359
Domain	PI-PLC-Y	PLCH1 PLCE1	2.26e-03	15	89	2	PF00387
Domain	PLCYc	PLCH1 PLCE1	2.26e-03	15	89	2	SM00149
Domain	EF-hand-dom_pair	CACNA1C CACNA1F DRP2 PLCH1 STAT2 PLCE1	2.50e-03	287	89	6	IPR011992
Domain	HEAT	VAC14 INTS4 XPO1	2.67e-03	58	89	3	IPR000357
Domain	PI-PLC-X	PLCH1 PLCE1	3.27e-03	18	89	2	PF00388
Domain	PLCXc	PLCH1 PLCE1	3.27e-03	18	89	2	SM00148
Domain	PIPLC_X_DOMAIN	PLCH1 PLCE1	3.64e-03	19	89	2	PS50007
Domain	PLipase_C_PInositol-sp_X_dom	PLCH1 PLCE1	3.64e-03	19	89	2	IPR000909
Domain	-	VAC14 TELO2 ASPM INTS4 XPO1	4.19e-03	222	89	5	1.25.10.10
Domain	Kinase-like_dom	CDK17 MARK3 FER HIPK2 ACAD10 CHEK1 ATM CDK14	4.31e-03	542	89	8	IPR011009
Domain	HEAT_REPEAT	VAC14 INTS4 XPO1	4.55e-03	70	89	3	PS50077
Domain	IQ	MYO5B IQCB1 ASPM	4.73e-03	71	89	3	PF00612
Pathway	WP_GPR40_PATHWAY	PKD1 PLCH1 PLCE1	4.69e-05	15	68	3	M39526
Pathway	KEGG_MEDICUS_REFERENCE_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1E CACNA1F	1.77e-04	23	68	3	M47666
Pathway	PID_P53_REGULATION_PATHWAY	KAT5 HIPK2 CHEK1 ATM	1.85e-04	59	68	4	M261
Pathway	BIOCARTA_RAN_PATHWAY	RANBP1 RANBP2	2.27e-04	5	68	2	M22082
Pathway	KEGG_MEDICUS_REFERENCE_CA2_ENTRY_VOLTAGE_GATED_CA2_CHANNEL	CACNA1C CACNA1E CACNA1F	2.29e-04	25	68	3	M47948
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	KAT5 CHEK1 ATM	2.58e-04	26	68	3	MM15297
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	RANBP2 KAT5 CENPH MCM5 CHEK1 ATM XPO1	3.20e-04	271	68	7	MM15388
Pathway	REACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS	KAT5 ATM	3.40e-04	6	68	2	M27585
Pathway	REACTOME_SENSING_OF_DNA_DOUBLE_STRAND_BREAKS	KAT5 ATM	3.40e-04	6	68	2	MM15295
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_VGCC_CA2_APOPTOTIC_PATHWAY	CACNA1C CACNA1F	3.40e-04	6	68	2	M47762
Pathway	REACTOME_CELL_CYCLE_CHECKPOINTS	RANBP2 KAT5 CENPH MCM5 CHEK1 ATM XPO1	4.91e-04	291	68	7	M16647
Pathway	BIOCARTA_PLK3_PATHWAY	CHEK1 ATM	6.30e-04	8	68	2	M22021
Pathway	REACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS	RANBP1 RANBP2 XPO1	7.42e-04	37	68	3	M27038
Pathway	BIOCARTA_CDC25_PATHWAY	CHEK1 ATM	8.08e-04	9	68	2	M22031
Pathway	KEGG_MEDICUS_REFERENCE_ATR_P21_CELL_CYCLE_G2_M	CHEK1 ATM	8.08e-04	9	68	2	M47586
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNB1 KCNV2 KCNS1	1.00e-03	41	68	3	MM14546
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	KAT5 HIPK2 CHEK1 ATM	1.01e-03	92	68	4	MM15338
Pathway	REACTOME_REGULATION_OF_TP53_ACTIVITY_THROUGH_PHOSPHORYLATION	KAT5 HIPK2 CHEK1 ATM	1.01e-03	92	68	4	M27636
Pathway	KEGG_MEDICUS_REFERENCE_CDC25_CELL_CYCLE_G2_M	CHEK1 ATM	1.01e-03	10	68	2	M47572
Pathway	REACTOME_HOMOLOGOUS_DNA_PAIRING_AND_STRAND_EXCHANGE	KAT5 CHEK1 ATM	1.15e-03	43	68	3	M27588
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNB1 KCNV2 KCNS1	1.15e-03	43	68	3	M1056
Pathway	REACTOME_PEXOPHAGY	ATM EPAS1	1.23e-03	11	68	2	M29846
Pathway	PID_RANBP2_PATHWAY	RANBP2 XPO1	1.23e-03	11	68	2	M140
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	CACNA1C CACNA1E	1.23e-03	11	68	2	M47958
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	CACNA1C CACNA1E CACNA1F SCN11A KCNB1 KCNV2 KCNS1	8.56e-08	139	91	7	16985003
Pubmed	Enhanced expression of L-type Cav1.3 calcium channels in murine embryonic hearts from Cav1.2-deficient mice.	CACNA1C CACNA1E CACNA1F	6.02e-07	7	91	3	12900400
Pubmed	p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress.	KAT5 CHEK1 ATM	9.61e-07	8	91	3	16705183
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	CFLAR CDK17 RANBP1 RANBP2 VAC14 GANAB HTR1E TELO2 MARK3 CENPH ASPM NIPSNAP2 MCM5 CDK14 SDAD1	1.17e-06	1284	91	15	17353931
Pubmed	International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels.	CACNA1C CACNA1E CACNA1F	1.44e-06	9	91	3	16382099
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RANBP1 RANBP2 XPO1	1.44e-06	9	91	3	10601307
Pubmed	Systematic analysis of human protein complexes identifies chromosome segregation proteins.	JPH1 CDK17 RANBP1 RANBP2 TRPC4AP GANAB INF2 ASPM CHEK1 ATM XPO1 GDI2 AQR THAP11	1.81e-06	1155	91	14	20360068
Pubmed	Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway.	MARK3 CHEK1 ATM	2.82e-06	11	91	3	11551930
Pubmed	Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics.	CABLES2 CACNA1E RANBP2 FAM193A SUPT6H FER MIOS ACAD10 GDI2	4.46e-06	475	91	9	31040226
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	CACNA1C CACNA1E RANBP1 RANBP2 SCN11A PHACTR2 MYO5B ASPM NIPSNAP2 MCM5 ZBTB41 ATM ZFC3H1 PLCH1 CAMSAP2	4.85e-06	1442	91	15	35575683
Pubmed	Kv2.1 channels play opposing roles in regulating membrane potential, Ca2+ channel function, and myogenic tone in arterial smooth muscle.	CACNA1C KCNB1	6.77e-06	2	91	2	32015129
Pubmed	Localization of the calcium channel subunits Cav1.2 (alpha1C) and Cav2.3 (alpha1E) in the mouse organ of Corti.	CACNA1C CACNA1E	6.77e-06	2	91	2	12973680
Pubmed	KAT5 and KAT6B are in positive regulation on cell proliferation of prostate cancer through PI3K-AKT signaling.	KAT5 KAT6B	6.77e-06	2	91	2	24294372
Pubmed	A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM.	KAT5 ATM	6.77e-06	2	91	2	16141325
Pubmed	Compound heterozygous KCNV2 variants contribute to cone dystrophy with supernormal rod responses in a Chinese family.	KCNB1 KCNV2	6.77e-06	2	91	2	34535971
Pubmed	Mammalian meiosis involves DNA double-strand breaks with 3' overhangs.	SPO11 ATM	6.77e-06	2	91	2	12644952
Pubmed	Polycystin-1 Is a Cardiomyocyte Mechanosensor That Governs L-Type Ca2+ Channel Protein Stability.	CACNA1C PKD1	6.77e-06	2	91	2	25888683
Pubmed	ATM promotes the obligate XY crossover and both crossover control and chromosome axis integrity on autosomes.	SPO11 ATM	6.77e-06	2	91	2	18497861
Pubmed	Molecular, Cellular and Functional Changes in the Retinas of Young Adult Mice Lacking the Voltage-Gated K+ Channel Subunits Kv8.2 and K2.1.	KCNB1 KCNV2	6.77e-06	2	91	2	34063002
Pubmed	Atm-dependent interactions of a mammalian chk1 homolog with meiotic chromosomes.	CHEK1 ATM	6.77e-06	2	91	2	9382850
Pubmed	Activation of ATM/Chk1 by curcumin causes cell cycle arrest and apoptosis in human pancreatic cancer cells.	CHEK1 ATM	6.77e-06	2	91	2	19401701
Pubmed	ATM and KAT5 safeguard replicating chromatin against formaldehyde damage.	KAT5 ATM	6.77e-06	2	91	2	26420831
Pubmed	Kidney Cyst Lining Epithelial Cells Are Resistant to Low-Dose Cisplatin-Induced DNA Damage in a Preclinical Model of Autosomal Dominant Polycystic Kidney Disease.	PKD1 ATM	6.77e-06	2	91	2	36293397
Pubmed	Zygotic G2/M cell cycle arrest induced by ATM/Chk1 activation and DNA repair in mouse embryos fertilized with hydrogen peroxide-treated epididymal mouse sperm.	CHEK1 ATM	6.77e-06	2	91	2	24040138
Pubmed	Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.	PKD1 ATM	6.77e-06	2	91	2	33802342
Pubmed	De novo deletions and duplications at recombination hotspots in mouse germlines.	SPO11 ATM	6.77e-06	2	91	2	34793701
Pubmed	Importin-β and CRM1 control a RANBP2 spatiotemporal switch essential for mitotic kinetochore function.	RANBP2 XPO1	6.77e-06	2	91	2	28600321
Pubmed	Voltage-activated calcium channel expression profiles in mouse brain and cultured hippocampal neurons.	CACNA1C CACNA1E CACNA1F	7.71e-06	15	91	3	20188150
Pubmed	Differential neuronal targeting of a new and two known calcium channel β4 subunit splice variants correlates with their regulation of gene expression.	CACNA1C CACNA1E CACNA1F	7.71e-06	15	91	3	24453333
Pubmed	VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells.	DDIAS TELO2 INF2 CENPH NFKB2 IQCB1 CHEK1	1.11e-05	288	91	7	23383273
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	JPH1 CABLES2 PHACTR2 GANAB INF2 MARK3 PLCH1 CABLES1	1.53e-05	421	91	8	36976175
Pubmed	Regulation of protein phosphatase 1I by Cdc25C-associated kinase 1 (C-TAK1) and PFTAIRE protein kinase.	MARK3 CDK14	2.03e-05	3	91	2	25028520
Pubmed	Electrically silent potassium channel subunits from human lens epithelium.	KCNB1 KCNS1	2.03e-05	3	91	2	10484328
Pubmed	The tumor suppressor, TAX1BP2, is a novel substrate of ATM kinase.	VAC14 ATM	2.03e-05	3	91	2	24240686
Pubmed	Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes.	SPO11 ATM	2.03e-05	3	91	2	26209650
Pubmed	Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway.	CHEK1 ATM	2.03e-05	3	91	2	20581453
Pubmed	ERK1/2 phosphorylates HIF-2α and regulates its activity by controlling its CRM1-dependent nuclear shuttling.	XPO1 EPAS1	2.03e-05	3	91	2	30962349
Pubmed	Novel inhibitors of nuclear transport cause cell cycle arrest and decrease cyst growth in ADPKD associated with decreased CDK4 levels.	PKD1 XPO1	2.03e-05	3	91	2	25234309
Pubmed	ik3-1/Cables is associated with Trap and Pctaire2.	CDK17 CABLES1	2.03e-05	3	91	2	11527406
Pubmed	Pectenotoxin-2 induces G2/M phase cell cycle arrest in human breast cancer cells via ATM and Chk1/2-mediated phosphorylation of cdc25C.	CHEK1 ATM	2.03e-05	3	91	2	20514472
Pubmed	Mutations in the nuclear export signal of human ran-binding protein RanBP1 block the Rev-mediated posttranscriptional regulation of human immunodeficiency virus type 1.	RANBP1 XPO1	2.03e-05	3	91	2	9111043
Pubmed	Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis.	HIPK2 ATM	2.03e-05	3	91	2	11780126
Pubmed	An allosteric mechanism to displace nuclear export cargo from CRM1 and RanGTP by RanBP1.	RANBP1 XPO1	2.03e-05	3	91	2	20485264
Pubmed	Two distinct classes of Ran-binding sites on the nucleoporin Nup-358.	RANBP1 RANBP2	2.03e-05	3	91	2	10318915
Pubmed	A segregating human allele of SPO11 modeled in mice disrupts timing and amounts of meiotic recombination, causing oligospermia and a decreased ovarian reserve†.	SPO11 ATM	2.03e-05	3	91	2	31074776
Pubmed	A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear export.	RANBP1 XPO1	2.03e-05	3	91	2	10330396
Pubmed	Regulation of Chk1 includes chromatin association and 14-3-3 binding following phosphorylation on Ser-345.	CHEK1 XPO1	2.03e-05	3	91	2	12676962
Pubmed	Zoledronate-induced S phase arrest and apoptosis accompanied by DNA damage and activation of the ATM/Chk1/cdc25 pathway in human osteosarcoma cells.	CHEK1 ATM	2.03e-05	3	91	2	17611684
Pubmed	The inhibition of HIF-2α on the ATM/Chk-2 pathway is involved in the promotion effect of arsenite on benzo(a)pyrene-induced cell transformation.	ATM EPAS1	2.03e-05	3	91	2	23333640
Pubmed	ATM pathway activation limits R-loop-associated genomic instability in Werner syndrome cells.	CHEK1 ATM	2.03e-05	3	91	2	30657978
Pubmed	ik3-2, a relative to ik3-1/Cables, is involved in both p53-mediated and p53-independent apoptotic pathways.	CABLES2 CABLES1	2.03e-05	3	91	2	14637168
Pubmed	The zebrafish grime mutant uncovers an evolutionarily conserved role for Tmem161b in the control of cardiac rhythm.	CACNA1C KCNV2	2.03e-05	3	91	2	33597309
Pubmed	The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM.	KAT5 ATM	2.03e-05	3	91	2	16603769
Pubmed	The Role of the Voltage-Gated Potassium Channel Proteins Kv8.2 and Kv2.1 in Vision and Retinal Disease: Insights from the Study of Mouse Gene Knock-Out Mutations.	KCNB1 KCNV2	2.03e-05	3	91	2	30820446
Pubmed	ATM kinase activity modulates Fas sensitivity through the regulation of FLIP in lymphoid cells.	CFLAR ATM	2.03e-05	3	91	2	17932249
Pubmed	Thymidylate kinase is critical for DNA repair via ATM-dependent Tip60 complex formation.	KAT5 ATM	2.03e-05	3	91	2	30199284
Pubmed	Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication.	RANBP1 XPO1	2.03e-05	3	91	2	16041368
Pubmed	The E3 ubiquitin ligase APC/CCdh1 degrades MCPH1 after MCPH1-βTrCP2-Cdc25A-mediated mitotic entry to ensure neurogenesis.	KAT5 SUPT6H MCM5 THAP11	2.63e-05	65	91	4	29150431
Pubmed	The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.	MARK3 CENPH IQCB1 ASPM MIOS XPO1 ZFC3H1 SDAD1 AQR THAP11	3.02e-05	759	91	10	35915203
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	JPH1 CDK17 GANAB FAM193A TELO2 INF2 MARK3 SUPT6H TRABD ASPM ATM ZFC3H1 PLCH1 AQR	3.14e-05	1487	91	14	33957083
Pubmed	Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals.	RANBP1 XPO1	4.05e-05	4	91	2	31021318
Pubmed	Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.	PLCH1 PLCE1	4.05e-05	4	91	2	21041529
Pubmed	Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.	CHEK1 ATM	4.05e-05	4	91	2	26061604
Pubmed	ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1.	CHEK1 ATM	4.05e-05	4	91	2	11390642
Pubmed	Chk1 is dispensable for G2 arrest in response to sustained DNA damage when the ATM/p53/p21 pathway is functional.	CHEK1 ATM	4.05e-05	4	91	2	21532626
Pubmed	NOTCH1 Inhibits Activation of ATM by Impairing the Formation of an ATM-FOXO3a-KAT5/Tip60 Complex.	KAT5 ATM	4.05e-05	4	91	2	27524627
Pubmed	RanBP1 stabilizes the interaction of Ran with p97 nuclear protein import.	RANBP1 RANBP2	4.05e-05	4	91	2	8909533
Pubmed	The interaction of ETV6 (TEL) and TIP60 requires a functional histone acetyltransferase domain in TIP60.	KAT5 KAT6B	4.05e-05	4	91	2	17980166
Pubmed	SPO11 is required for sex-body formation, and Spo11 heterozygosity rescues the prophase arrest of Atm-/- spermatocytes.	SPO11 ATM	4.05e-05	4	91	2	15998665
Pubmed	Surveillance of different recombination defects in mouse spermatocytes yields distinct responses despite elimination at an identical developmental stage.	SPO11 ATM	4.05e-05	4	91	2	16055729
Pubmed	Large T antigen promotes JC virus replication in G2-arrested cells by inducing ATM- and ATR-mediated G2 checkpoint signaling.	CHEK1 ATM	4.05e-05	4	91	2	19903823
Pubmed	Beta-adrenergic-regulated phosphorylation of the skeletal muscle Ca(V)1.1 channel in the fight-or-flight response.	CACNA1C CACNA1F	4.05e-05	4	91	2	20937870
Pubmed	Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer.	CHEK1 ATM	4.05e-05	4	91	2	18381943
Pubmed	Isolated polycystic liver disease genes define effectors of polycystin-1 function.	GANAB PKD1	4.05e-05	4	91	2	28375157
Pubmed	Whole-genome association study of bipolar disorder.	CACNA1C MYO5B	4.05e-05	4	91	2	18317468
Pubmed	Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60.	KAT5 ATM	4.05e-05	4	91	2	19783983
Pubmed	Analysis of the ATR-Chk1 and ATM-Chk2 pathways in male breast cancer revealed the prognostic significance of ATR expression.	CHEK1 ATM	4.05e-05	4	91	2	28808232
Pubmed	Structure of the Human TELO2-TTI1-TTI2 Complex.	TELO2 ATM	4.05e-05	4	91	2	34838521
Pubmed	The ATM-Chk2 and ATR-Chk1 pathways in DNA damage signaling and cancer.	CHEK1 ATM	4.05e-05	4	91	2	21034966
Pubmed	GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358.	RANBP1 RANBP2	4.05e-05	4	91	2	10473610
Pubmed	Facilitated nucleocytoplasmic shuttling of the Ran binding protein RanBP1.	RANBP1 XPO1	4.05e-05	4	91	2	10779340
Pubmed	Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.	CHEK1 ATM	4.05e-05	4	91	2	12676583
Pubmed	ATM mediates phosphorylation at multiple p53 sites, including Ser(46), in response to ionizing radiation.	HIPK2 ATM	4.05e-05	4	91	2	11875057
Pubmed	ATM controls meiotic double-strand-break formation.	SPO11 ATM	4.05e-05	4	91	2	22002603
Pubmed	XRRA1 Targets ATM/CHK1/2-Mediated DNA Repair in Colorectal Cancer.	CHEK1 ATM	4.05e-05	4	91	2	29082250
Pubmed	Phosphoproteomics screen reveals akt isoform-specific signals linking RNA processing to lung cancer.	SUPT6H PKD1 CABLES1	5.41e-05	28	91	3	24462114
Pubmed	Proteomic identification of the MYST domain histone acetyltransferase TIP60 (HTATIP) as a co-activator of the myeloid transcription factor C/EBPalpha.	RANBP2 KAT5 MCM5	6.03e-05	29	91	3	18239623
Pubmed	Differential roles for checkpoint kinases in DNA damage-dependent degradation of the Cdc25A protein phosphatase.	CHEK1 ATM	6.74e-05	5	91	2	18480045
Pubmed	A giant nucleopore protein that binds Ran/TC4.	RANBP1 RANBP2	6.74e-05	5	91	2	7603572
Pubmed	Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.	HIPK2 ATM	6.74e-05	5	91	2	18536714
Pubmed	ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency.	CHEK1 ATM	6.74e-05	5	91	2	16675955
Pubmed	Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability.	KAT5 CHEK1	6.74e-05	5	91	2	29760279
Pubmed	Sam68 marks the transcriptionally active stages of spermatogenesis and modulates alternative splicing in male germ cells.	SPO11 ATM	6.74e-05	5	91	2	21355037
Pubmed	Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint.	CHEK1 ATM	6.74e-05	5	91	2	10859164
Pubmed	The many substrates and functions of ATM.	CHEK1 ATM	6.74e-05	5	91	2	11252893
Pubmed	Antinociceptive effect of different types of calcium channel inhibitors and the distribution of various calcium channel alpha 1 subunits in the dorsal horn of spinal cord in mice.	CACNA1C CACNA1E	6.74e-05	5	91	2	15451373
Pubmed	Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.	CHEK1 ATM	6.74e-05	5	91	2	12955071
Pubmed	ik3-2, a relative to ik3-1/cables, is associated with cdk3, cdk5, and c-abl.	CABLES2 CABLES1	6.74e-05	5	91	2	11955625
Pubmed	The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.	SPO11 ATM	6.74e-05	5	91	2	24532689
Pubmed	Kv2.1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons.	CACNA1C KCNB1	6.74e-05	5	91	2	31663850
Interaction	MCPH1 interactions	KAT5 SUPT6H MCM5 CHEK1 ATM THAP11	5.66e-06	101	89	6	int:MCPH1
Interaction	EGLN3 interactions	CDK17 RANBP1 RANBP2 VAC14 GANAB FAM193A TELO2 TRABD IQCB1 ASPM MIOS NIPSNAP2 MCM5 XPO1 PLCH1 CDK14 CAMSAP2 EPAS1	1.21e-05	1296	89	18	int:EGLN3
GeneFamily	Calcium voltage-gated channel subunits	CACNA1C CACNA1E CACNA1F	7.34e-05	26	57	3	253
GeneFamily	Potassium voltage-gated channels	KCNB1 KCNV2 KCNS1	2.70e-04	40	57	3	274
GeneFamily	Zinc fingers C2HC-type\|PHD finger proteins\|Lysine acetyltransferases	KAT5 KAT6B	1.14e-03	16	57	2	66
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	KAT5 KAT6B	1.29e-03	17	57	2	486
GeneFamily	Phospholipases\|C2 domain containing phospholipases	PLCH1 PLCE1	1.61e-03	19	57	2	832
GeneFamily	Cyclin dependent kinases	CDK17 CDK14	3.02e-03	26	57	2	496
GeneFamily	SH2 domain containing	SUPT6H FER STAT2	3.98e-03	101	57	3	741
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CACNA1E TRABD CENPH ASPM CAMSAP2 RFPL3S S1PR4	5.78e-08	169	91	7	c8691c4f707d46b2865fe46eabe24ea4d03c7b43
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F DRP2 PLCH1 PKHD1L1 DSCAML1 UNC80 PLCE1	1.03e-07	184	91	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F DRP2 PLCH1 PKHD1L1 DSCAML1 UNC80 PLCE1	1.03e-07	184	91	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CACNA1F DRP2 PLCH1 PKHD1L1 DSCAML1 UNC80 PLCE1	1.03e-07	184	91	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Children_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CACNA1E KLHDC8A SLC4A10 DSCAML1 SLC16A12 UNC80	1.23e-06	167	91	6	c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCell	COVID-19-Heart-Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	CACNA1C HIPK2 PLEKHG2 DSCAML1 SLC16A12 PLCE1	2.15e-06	184	91	6	21790cdfa3b4036ad413fd44b94e31563116f25f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C KCNB1 PKD1 SLC4A10 CDK14 UNC80	3.10e-06	196	91	6	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C KCNB1 PKD1 SLC4A10 CDK14 UNC80	3.29e-06	198	91	6	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	356C-Lymphocytic-NK_cells-Proliferating_NK_cell\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	DDIAS RANBP1 CENPH ASPM MCM5 CHEK1	3.48e-06	200	91	6	97e47eb69d1d4cab45256acca9589837eb7817e7
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	CACNA1C KCNB1 PKD1 SLC4A10 CDK14 UNC80	3.48e-06	200	91	6	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	DDX60L ATM SLFN5 XPO1 ZFC3H1 STAT2	3.48e-06	200	91	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	E17.5-Epithelial-airway_epithelial_cell-ciliated_cell_of_airway\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TCF21 MARK3 LRP4 ABCB11 SLC16A12	1.42e-05	150	91	5	201d5b68e71c6c003285428be96c488e6d526edf
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD22 ATCAY PLEKHG2 DSCAML1	1.53e-05	73	91	4	3ac392ac46ad577c7d2c2b5e6a0a96ceb613097b
ToppCell	facs-Pancreas-Endocrine-3m-Epithelial-pancreatic_acinar_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ANKRD22 ATCAY PLEKHG2 DSCAML1	1.53e-05	73	91	4	1bd6ff9659efc43b0a596da50e325bde2f0ba8f7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Myeloid-Granulocytic-Mast_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VAC14 TCP11L2 NFKB2 FER SLC4A10	2.00e-05	161	91	5	c54010d88f1ecb6e0235bb66084876a4d5bf1ecd
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_airway-SCMF-SCMF_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	JPH1 RANBP1 CENPH MCM5 CHEK1	2.06e-05	162	91	5	3f264263878af630921911c2b344ac56eb1e7099
ToppCell	control-dn_T\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CACNA1F PHACTR2 ASPM SLFN5 S1PR4	2.60e-05	170	91	5	839f62860b4a52d06e6a8fce7632195c7310b89d
ToppCell	E16.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-AF1-AF1_G2M\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CFLAR IL16 TCF21 LRP4 STAT2	3.24e-05	178	91	5	c87945146b2734141f07b39d268e0d8086ee0364
ToppCell	3'_v3-blood-Lymphocytic_B_plasma-Plasmablasts\|blood / Manually curated celltypes from each tissue	ASPM MCM5 CHEK1 PKHD1L1 CNGB1	3.32e-05	179	91	5	7d3bd1f9e126a4a9e0a84720a6cc0b3d235e65ee
ToppCell	Posterior_cortex-Hematopoietic-MICROGLIA\|Posterior_cortex / BrainAtlas - Mouse McCarroll V32	CACNA1F IL16 GDI2 SLC2A5 NCKAP1L	3.32e-05	179	91	5	5122fc794509492afde4af8b1b76d51e3070ef05
ToppCell	10x5'-Liver-Lymphocytic_T_CD4/8-lo-Cycling_T\|Liver / Manually curated celltypes from each tissue	RANBP1 CENPH ASPM MCM5 CHEK1	3.60e-05	182	91	5	81557cdc88777f3bd4e1dd18a760b08fc29122ef
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4/8-lo-Cycling_T\|bone_marrow / Manually curated celltypes from each tissue	DRP2 CENPH ASPM MCM5 CHEK1	3.69e-05	183	91	5	a48a6313f2f144586951cece97ec31f6d72361df
ToppCell	droplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Endothelial-leukocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	JPH1 MYO5B CENPH PKHD1L1 SLC16A12	3.69e-05	183	91	5	919c9861073d12fd12aecd7469b1478b13838c43
ToppCell	Striatum-Macroglia-POLYDENDROCYTE-P5\|Striatum / BrainAtlas - Mouse McCarroll V32	RANBP1 CENPH ASPM MCM5 CHEK1	3.69e-05	183	91	5	f20b0d71f857ac35868fd80531050ad8b6091716
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDIAS CENPH ATCAY ASPM MCM5	3.79e-05	184	91	5	1edefa2a049d7e22d0bdb1ea3d7ef1c8d6ae0fe3
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-Proliferating_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DDIAS CENPH ATCAY ASPM MCM5	3.79e-05	184	91	5	8578c50eaa8ce1cefc0228185c66c8e25f4bfc32
ToppCell	droplet-Pancreas-Endocrine-18m-Endothelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PHACTR2 SLFN5 CNGB1 EPAS1 CABLES1	3.89e-05	185	91	5	512a195ebbae445afe3722a3943020080daf2f3c
ToppCell	COVID-19-lung-Plasma_cells_PRDM1/BLIMP_hi\|lung / Disease (COVID-19 only), tissue and cell type	DDIAS IQCB1 ASPM CDK14 SLC2A5	3.99e-05	186	91	5	66676d9395172de5707e204826a1c9f73b448cca
ToppCell	RV-07._Pericyte\|RV / Chamber and Cluster_Paper	HIPK2 DSCAML1 SLC16A12 EPAS1 PLCE1	3.99e-05	186	91	5	c533b264fbe12bc35467486fc7fbde24ba968fe1
ToppCell	RV-07._Pericyte\|World / Chamber and Cluster_Paper	CACNA1C HIPK2 DSCAML1 SLC16A12 EPAS1	4.09e-05	187	91	5	dc274d6bbda619a2c914d84e2b4069cfef1739d1
ToppCell	droplet-Lung-3m-Hematologic-Lymphocytic_NK_ILC-natural_killer_cell-proliferating_NK\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CENPH ASPM MCM5 CHEK1 PLCH1	4.20e-05	188	91	5	0ec2a1b0505501ba18f10a5fce68c306a6292419
ToppCell	normal-na-Lymphocytic\|normal / PBMC cell types (v2) per disease, treatment status, and sex	JPH1 CENPH ASPM MCM5 CHEK1	4.31e-05	189	91	5	1d382f8eb998c6a30e09fddc9a427afc8f5f7323
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	DDIAS INF2 DDX60L S1PR4 NCKAP1L	4.31e-05	189	91	5	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	normal-na-Lymphocytic-lymphocyte\|normal / PBMC cell types (v2) per disease, treatment status, and sex	JPH1 CENPH ASPM MCM5 CHEK1	4.31e-05	189	91	5	b83fd81ecc5ef363be7435ee12cb7079e2434af7
ToppCell	LPS_only-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1C TCF21 ABCA6 CDK14 SLC16A12	4.31e-05	189	91	5	2a22b9fae70afb3dab8476f9c00e48a4df756410
ToppCell	normal-na-Lymphocytic-lymphocyte-female\|normal / PBMC cell types (v2) per disease, treatment status, and sex	JPH1 CENPH ASPM MCM5 CHEK1	4.31e-05	189	91	5	3db4177d68cab4cd16842d2ebcaca28f69300e44
ToppCell	COVID-19-Lymphoid-Plasma,_B_cells\|Lymphoid / Condition, Lineage and Cell class	HIPK2 CDK14 PKHD1L1 SLC2A5 CABLES1	4.53e-05	191	91	5	bcdadf83cb9653f9cc2a281e7c1095fe8f79173c
ToppCell	control-T/NK_proliferative\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	RANBP1 CENPH ASPM MCM5 CHEK1	4.76e-05	193	91	5	ecb4018a47d9a82bb999e0bc8b3dceabd97d1f0d
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DDIAS CENPH ASPM MCM5 CHEK1	4.87e-05	194	91	5	590a9d4f054e6a3685daf752c9354650fcc7d18a
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	DDIAS RANBP1 CENPH MCM5 CHEK1	4.99e-05	195	91	5	cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DDIAS RANBP1 CENPH MCM5 CHEK1	4.99e-05	195	91	5	b65463a804fed2d9a3be9e528ca8b9c98469bc86
ToppCell	mild-Lymphocytic-Prol._cells\|mild / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RANBP1 CENPH ASPM MCM5 CHEK1	4.99e-05	195	91	5	9a8cc9097a349fd0a53ccf2723ee8bb1418d6aca
ToppCell	ILEUM-non-inflamed-(1)_Highly_activated_T_cells\|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RANBP1 CENPH ASPM MCM5 CHEK1	5.12e-05	196	91	5	6a415a2574bd84bd825a2bd6c8e3632a433ff7cf
ToppCell	lymphoid-T_cell-Regulatory_T_cell\|World / Lineage, cell class and subclass	INF2 SLC4A10 SLFN5 PTGDR2 S1PR4	5.12e-05	196	91	5	42a4d706382be33d552ece1d0598d073857a8d4e
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DDIAS RANBP1 CENPH MCM5 CHEK1	5.12e-05	196	91	5	df366d76ea55f49e349d622effa57c1535df8400
ToppCell	severe-T/NK_proliferative\|severe / disease stage, cell group and cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.12e-05	196	91	5	89f005216770dbb84378f5d1f20ca11b0ce40faa
ToppCell	mild-Lymphocytic-Prol._cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RANBP1 CENPH ASPM MCM5 CHEK1	5.12e-05	196	91	5	b1d9866d5dfaefdb8bedaf01a750d97987acb3d1
ToppCell	343B-Myeloid-Dendritic\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	ANKRD22 ASPM MCM5 CHEK1 GDI2	5.24e-05	197	91	5	b340d6f041231e5c69140895aaa1e8d28bafb998
ToppCell	severe-T/NK_proliferative\|World / disease stage, cell group and cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.24e-05	197	91	5	6b7b068b103fd4f6ceda8e01f4dd39eefc3b3633
ToppCell	10x5'-blood-Lymphocytic_T_CD4/8-lo-Cycling_T\|blood / Manually curated celltypes from each tissue	RANBP1 CENPH ASPM MCM5 CHEK1	5.24e-05	197	91	5	1f7c3d193647b66cce6ea202a40758cd10b8bd12
ToppCell	10x5'-blood-Lymphocytic_T_CD4/8-lo\|blood / Manually curated celltypes from each tissue	RANBP1 CENPH ASPM MCM5 CHEK1	5.24e-05	197	91	5	acd678586aa0e4375bc8fbcdaa1a796c8dd23885
ToppCell	myeloid-CD34+_Monoblast\|myeloid / Lineage and Cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.37e-05	198	91	5	e26b98a8380e693110a97d8e5a353998f8d67c6d
ToppCell	Parenchymal-10x5prime-Immune_Lymphocytic-B-B_plasma-B_plasmablast\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	CENPH ASPM MCM5 CHEK1 SLC2A5	5.37e-05	198	91	5	cfbe0bae21b6cd9cd15d3e659b618b44cfe3eaec
ToppCell	severe-Lymphocytic-Prol._cells\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RANBP1 CENPH ASPM MCM5 CHEK1	5.37e-05	198	91	5	4d8591eabb543ed789f963b507a07c560c76a7c9
ToppCell	(0)_NK_cells-(0)_NK_Dividing\|(0)_NK_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	DDIAS CENPH ASPM MCM5 CHEK1	5.37e-05	198	91	5	d9cdbc7d420472cb1ffb36ad9c8e53a61b7dbdeb
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CACNA1C KCNB1 SLC4A10 CDK14 UNC80	5.37e-05	198	91	5	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	MS-cycling-\|MS / Condition, Cell_class and T cell subcluster	DDIAS ASPM MCM5 CHEK1 PKHD1L1	5.37e-05	198	91	5	19c5d6b65de490118574b1f86b45c58b3a51df7f
ToppCell	metastatic_Lymph_Node-T/NK_cells-Undetermined\|metastatic_Lymph_Node / Location, Cell class and cell subclass	RANBP1 CENPH ASPM MCM5 CHEK1	5.37e-05	198	91	5	f9f083c76c51b6f014ecf80eaec957eff8d1ab75
ToppCell	MS-cycling\|MS / Condition, Cell_class and T cell subcluster	DDIAS ASPM MCM5 CHEK1 PKHD1L1	5.37e-05	198	91	5	0c22f2cc0e5ca91cabcd4aac2b9ef05af47e967f
ToppCell	Non-neuronal-Dividing-Radial_Glia-vRG-11\|World / Primary Cells by Cluster	RANBP1 CENPH ASPM MCM5 CHEK1	5.37e-05	198	91	5	672c6faeed54e1397e12c0aac1a5cbd19c684f06
ToppCell	BAL-Severe\|BAL / Compartment, Disease Groups and Clusters	CFLAR ANKRD22 DDX60L SLFN5 STAT2	5.37e-05	198	91	5	f63cfcc57f46094ea0673bbc70ea443ebaca6176
ToppCell	severe-Plasmablast\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ASPM CDK14 PKHD1L1 SLC2A5 CABLES1	5.50e-05	199	91	5	6ee4c2e6049860071169366b7e662d5c1a3cc54b
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	4394dcd1809f49e9bada8f5e115d5123356eae3e
ToppCell	remission-T/NK_proliferative\|remission / disease stage, cell group and cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	303a5fc43a48b05b6f2060d99eef4adc36f8d4e3
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative-\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	c0ea391bb347b99b94b5d7f02612ede938986745
ToppCell	normal_Lung-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	4142d5b1b20212508f95841fdac4efb7655616cb
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	96af1f289552f38f2dfa181192eb3276f4c7d70b
ToppCell	remission-T/NK_proliferative\|World / disease stage, cell group and cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	f305f3a454b7d2170429bad087480ccccca19acd
ToppCell	COVID-19_Convalescent-Lymphoid_T/NK-T/NK_proliferative\|COVID-19_Convalescent / Disease group, lineage and cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	893b78c661c529db07a5fcc3124d9b3d0f270fa5
ToppCell	COVID-19_Convalescent-T/NK_proliferative\|COVID-19_Convalescent / Disease condition and Cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	c608d953b852b67a4e36bd63d45f0deec3eefbd9
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T-T/NK_proliferative\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	5b18e18ddbf4bd53aa0d574d23092cb96da7f400
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	6df65f4c2f9a125e0c7c4f597fefc05a97fc8831
ToppCell	severe-Lymphocytic-Prol._cells\|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	b24315952b6ac6c8d2d3a7bd949a5b5392624d4e
ToppCell	PBMC-Convalescent-Lymphocyte-T/NK-Other_T\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	cb229aa3eb7b1cc47e76711b8fc18fce88a5cf08
ToppCell	ILEUM-non-inflamed-(1)_T_cell-(1)_Highly_activated_T_cells\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RANBP1 CENPH ASPM MCM5 CHEK1	5.50e-05	199	91	5	f9bf94ab6b5b134f5b98a65340843b147941ab58
ToppCell	COVID-19-COVID-19_Mild-Lymphocyte-T/NK-dn_T\|COVID-19_Mild / Disease, condition lineage and cell class	IL16 PHACTR2 MCM5 SLFN5 S1PR4	5.50e-05	199	91	5	f307d4887b28cf60a591439e278fd668409cb104
ToppCell	10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	RANBP1 CENPH KLHDC8A ASPM NIPSNAP2	5.50e-05	199	91	5	89d7622c4ae146900d963ac68c6bf011e8674665
ToppCell	Control-Control-Lymphocyte-T/NK-dn_T\|Control / Disease, condition lineage and cell class	CACNA1F IL16 PHACTR2 SLFN5 S1PR4	5.63e-05	200	91	5	10882c59b7aaf8bd4b5c00aa4ddbb9f7ac5b2cf5
ToppCell	NS-moderate-d_16-33-Lymphoid-NKT-proliferating\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	7b7a5800798a3e7eba164fbc28312dd09c57a2c3
ToppCell	metastatic_Lymph_Node-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	9c2095dcf70f1288d55d0ff4a97efd4fd8d0c9ee
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_Highly_activated_T_cells\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	d92d3bc63a56a604d7b1d49e62d4304e5e4017f2
ToppCell	Severe-T/NK_proliferative\|Severe / Disease group and Cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	4723613a9f56bff422fc98722128d57b6adf3c5d
ToppCell	ILEUM-inflamed-(1)_Highly_activated_T_cells\|inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	6ff811fdfe49b5b0aea0e88fae80bfaaf40eb7c4
ToppCell	NS-critical-d_07-13-Lymphoid-NKT-proliferating\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DDIAS CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	7f5cd05bb1b9a83baceddb7d7f0a9ec9781cda29
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	PHACTR2 MYO5B KLHDC8A PLCH1 PLCE1	5.63e-05	200	91	5	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	Severe-T/NK_proliferative\|World / Disease group and Cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	128d82eb4d5760adf872212d8e8b5787a889969f
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Undetermined\|T/NK_cells / Location, Cell class and cell subclass	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	cfec2f712b870797fab3b0770f16feaafd37e8d5
ToppCell	COVID-19-COVID-19_Convalescent-Lymphocyte-T/NK-T/NK_proliferative\|COVID-19_Convalescent / Disease, condition lineage and cell class	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	00538c4cbab5da00b3a366717d38a3ba5cfe3f65
ToppCell	moderate-Lymphoid-NKT-proliferating\|moderate / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	RANBP1 CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	8692e6664f0bb2be990f7563888380bb47414626
ToppCell	Brain_organoid-organoid_Paulsen_bioRxiv-6_mon-Proliferating\|6_mon / Sample Type, Dataset, Time_group, and Cell type.	DDIAS CENPH ASPM MCM5 CHEK1	5.63e-05	200	91	5	8f9e76048ae6f45218a09a95a2c4b31e8a8937b2
ToppCell	frontal_cortex-Non-neuronal-pericyte_cell-Peri-Peri_Kcnj8\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLEKHG2 SLC16A12 EPAS1 PTGDR2	1.15e-04	122	91	4	c16110934172f174f4aefe14b81abce8514b30f0
ToppCell	frontal_cortex-Non-neuronal-pericyte_cell-Peri\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLEKHG2 SLC16A12 EPAS1 PTGDR2	1.15e-04	122	91	4	006ac4f6807e688554d36557d29d5e5a0bc3c36f
ToppCell	frontal_cortex-Non-neuronal-pericyte_cell\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	PLEKHG2 SLC16A12 EPAS1 PTGDR2	1.15e-04	122	91	4	f3d9a5893fdee3562880fb6fc132b88169a7d997
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)\|Thalamus / BrainAtlas - Mouse McCarroll V32	RTF2 FER CNGB1 S1PR4	2.05e-04	142	91	4	58bfff3284ae21150e4619511bd58622c16c5dde
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)--\|Thalamus / BrainAtlas - Mouse McCarroll V32	RTF2 FER CNGB1 S1PR4	2.05e-04	142	91	4	5fd737c1fee9d97aee8955f1bf378ead3fce138d
ToppCell	Thalamus-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Pi16_(Pi16)-\|Thalamus / BrainAtlas - Mouse McCarroll V32	RTF2 FER CNGB1 S1PR4	2.05e-04	142	91	4	16f9945e835c3506b12d904778560d065a50f059
ToppCell	NS-critical-d_0-4-Myeloid-pDC\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	ASPM MCM5 CNGB1 SLC2A5	2.17e-04	144	91	4	0fde5cd82df9b90aefde19275cff6c2ec3c9d5cb
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Otof-Lmo2_(eccentric_SPN,_dSPN-like_markers)-\|Striatum / BrainAtlas - Mouse McCarroll V32	ANKRD22 SPO11 PKHD1L1	2.40e-04	59	91	3	dbb61f03be7d2c7fa7d32c743fcff2dc91ae0d75
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Otof-Lmo2_(eccentric_SPN,_dSPN-like_markers)\|Striatum / BrainAtlas - Mouse McCarroll V32	ANKRD22 SPO11 PKHD1L1	2.40e-04	59	91	3	e6cbbe1a4961066cae8f8c03a838f37e60a5391a
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1F STX19 MYO5B DSCAML1	2.53e-04	150	91	4	9cb3332924bd67c966873343c14445e30d3f384f
Drug	Naftifine hydrochloride [65473-14-5]; Down 200; 12.4uM; HL60; HT_HG-U133A	CFLAR VAC14 SUPT6H NFKB2 FER ACAD10 KAT6B EPAS1 S1PR4	8.36e-08	196	90	9	2974_DN
Drug	NSC683246	CACNA1C CDK17 PKD1 HIPK2 ABCB11 CHEK1 XPO1 CDK14 EPAS1	3.76e-07	234	90	9	CID000005097
Drug	AC1L1KS5	CACNA1C CACNA1E CACNA1F KAT5 PKD1 PLCH1 PTGDR2 SLC2A5 PLCE1	7.03e-06	334	90	9	CID000005631
Drug	AC1L2AC7	CACNA1C CACNA1E CACNA1F NFKB2 PKD1	7.94e-06	69	90	5	CID000068733
Drug	CNS 1145	CACNA1C CACNA1E CACNA1F PKD1	8.56e-06	33	90	4	CID000190902
Drug	IHC-64	CACNA1C CACNA1E CACNA1F PKD1	8.56e-06	33	90	4	CID000162753
Drug	Alprenolol hydrochloride [13707-88-5]; Down 200; 14uM; HL60; HG-U133A	CFLAR RANBP2 HIPK2 KCNS1 ATM SLC2A5 NCKAP1L	1.37e-05	198	90	7	1571_DN
Drug	Basic Violet 11:1	CFLAR ATM	1.55e-05	2	90	2	CID000062265
Drug	U46619	CACNA1C CACNA1E CACNA1F SUPT6H PKD1 PLCH1 PTGDR2 PLCE1	1.74e-05	285	90	8	CID000005618
Drug	verapamil	CACNA1C CACNA1E CACNA1F KCNB1 ABCA6 MYO5B KCNV2 PKD1 ABCB11 KCNS1	2.39e-05	490	90	10	CID000002520
Drug	AC1NUZ8M	CFLAR CACNA1C NFKB2 PKD1 PTGDR2	3.24e-05	92	90	5	CID000073211
Drug	[(4E)-4-[(2,2-difluoroethylamino)methylene]-6-methyl-5-oxo-3-pyridyl]methyl dihydrogen phosphate	CACNA1E IL16 ABCB11	3.90e-05	17	90	3	CID011840958
Drug	Isradipine	CACNA1E CACNA1F ABCB11	4.67e-05	18	90	3	ctd:D017275
Drug	ICRF-193	CHEK1 ATM XPO1 CDK14	6.21e-05	54	90	4	CID000115150
Drug	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	CFLAR KAT5 MYO5B PKD1 HIPK2 NIPSNAP2 MCM5 CHEK1 PLEKHG2 EPAS1	7.12e-05	558	90	10	ctd:C072553
Drug	papaverine	CACNA1C CACNA1E CACNA1F PKD1 PLCH1 PLCE1	7.13e-05	176	90	6	CID000004680
Drug	Cinildipine	CACNA1C CACNA1E CACNA1F PKD1	7.17e-05	56	90	4	CID000002752
Drug	pyrachlostrobin	DDIAS PHACTR2 MYO5B KLHDC8A NFKB2 ASPM LRP4 ACAD10 SLFN5 PLEKHG2 EPAS1 PLCE1	8.23e-05	811	90	12	ctd:C513428
Drug	nilvadipine	CACNA1C CACNA1E CACNA1F PKD1	9.40e-05	60	90	4	CID000004494
Drug	IAA-94	CACNA1C CACNA1E CACNA1F PKD1	1.00e-04	61	90	4	CID000003667
Drug	AC1NBU2S	CACNA1C CACNA1E CACNA1F NFKB2 PKD1	1.02e-04	117	90	5	CID004473765
Drug	Etidronic acid, disodium salt [7414-83-7]; Down 200; 16uM; MCF7; HT_HG-U133A	CFLAR TRPC4AP HTR1E ACAD10 ATM AQR	1.03e-04	188	90	6	3325_DN
Drug	EGTA-AM	CACNA1C CACNA1E RANBP2 XPO1	1.07e-04	62	90	4	CID000121907
Drug	NSC759576	CACNA1C CACNA1E CACNA1F NFKB2 PKD1 CNGB1	1.12e-04	191	90	6	CID000003075
Drug	lercanidipine	CACNA1C CACNA1E CACNA1F PKD1	1.14e-04	63	90	4	CID000065866
Drug	Cefsulodin sodium salt [52152-93-9]; Up 200; 7.2uM; MCF7; HT_HG-U133A	CFLAR NFKB2 KCNS1 ATM STAT2 PLCE1	1.25e-04	195	90	6	4148_UP
Drug	Sulpiride [15676-16-1]; Up 200; 11.8uM; HL60; HG-U133A	CFLAR GANAB SUPT6H TRABD KCNS1 CHEK1	1.29e-04	196	90	6	1967_UP
Drug	Pipemidic acid [51940-44-4]; Down 200; 13.2uM; HL60; HT_HG-U133A	CFLAR CDK17 KCNS1 AQR STAT2 SLC2A5	1.29e-04	196	90	6	3093_DN
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Up 200; 14.6uM; MCF7; HT_HG-U133A	CFLAR KAT5 NFKB2 MIOS KCNS1 ATM	1.32e-04	197	90	6	2892_UP
Drug	genistein; Up 200; 10uM; MCF7; HT_HG-U133A	CFLAR FER HIPK2 ACAD10 PLCH1 AQR	1.32e-04	197	90	6	6994_UP
Drug	Phenindione [83-12-5]; Down 200; 18uM; MCF7; HT_HG-U133A	CFLAR TELO2 SUPT6H FER ATM KAT6B	1.32e-04	197	90	6	2868_DN
Drug	Fluorocurarine chloride [22273-09-2]; Up 200; 11.6uM; MCF7; HT_HG-U133A	IL16 KCNB1 KCNS1 EPAS1 PTGDR2 STAT2	1.32e-04	197	90	6	6083_UP
Drug	sodium 4-phenylbutyrate; Down 200; 1000uM; MCF7; HG-U133A	VAC14 KAT5 KCNB1 SUPT6H MCM5 NCKAP1L	1.36e-04	198	90	6	407_DN
Drug	rosiglitazone maleate; Up 200; 10uM; HL60; HG-U133A	CFLAR VAC14 TELO2 TRABD HIPK2 ATM	1.36e-04	198	90	6	369_UP
Drug	Nisoxetine hydrochloride [57754-86-6]; Down 200; 13uM; HL60; HT_HG-U133A	INF2 TRABD HIPK2 CAMSAP2 EPAS1 S1PR4	1.36e-04	198	90	6	3117_DN
Drug	Sarin	CFLAR RANBP1 HTR1E KAT5 HIPK2 KAT6B GDI2	1.41e-04	286	90	7	ctd:D012524
Drug	gallopamil	CACNA1C CACNA1E CACNA1F PKD1	1.45e-04	67	90	4	CID000001234
Disease	Autosomal dominant polycystic kidney disease	GANAB PKD1	2.75e-05	3	90	2	cv:C0085413
Disease	Cholestasis, progressive familial intrahepatic 1	MYO5B ABCB11	5.50e-05	4	90	2	C4551898
Disease	Timothy syndrome (implicated_via_orthology)	CACNA1C CACNA1F	5.50e-05	4	90	2	DOID:0060173 (implicated_via_orthology)
Disease	total blood protein measurement	CFLAR CABLES2 TRPC4AP ABCA6 CENPH PKD1 XPO1 PLCE1	7.04e-05	449	90	8	EFO_0004536
Disease	Duchenne muscular dystrophy (implicated_via_orthology)	CACNA1C CACNA1F DRP2	1.82e-04	36	90	3	DOID:11723 (implicated_via_orthology)
Disease	Polycystic kidney disease, type 2	GANAB PKD1	1.91e-04	7	90	2	C2751306
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	GANAB PKD1	2.55e-04	8	90	2	C0887850
Disease	Charcot-Marie-Tooth disease	JPH1 DRP2 INF2	2.89e-04	42	90	3	cv:C0007959
Disease	Polycystic Kidney, Autosomal Dominant	GANAB PKD1	3.27e-04	9	90	2	C0085413
Disease	gastric adenocarcinoma (is_implicated_in)	XPO1 PLCE1	4.97e-04	11	90	2	DOID:3717 (is_implicated_in)
Disease	pulse pressure measurement	VAC14 FAM193A MARK3 SUPT6H PKD1 FER ABCB11 ZBTB41 ACAD10 CDK14 CCNYL2 PLCE1	1.06e-03	1392	90	12	EFO_0005763
Disease	Myopia	SCN11A TCP11L2 MYO5B DDX60L DSCAML1 SLC2A5	1.18e-03	385	90	6	HP_0000545
Disease	coagulation factor measurement	ASPM ZBTB41	1.69e-03	20	90	2	EFO_0004634
Disease	Granulomatous Slack Skin	NFKB2 ATM	2.04e-03	22	90	2	C0376407
Disease	amblyopia	CACNA1E CNGB1	2.04e-03	22	90	2	MONDO_0001020
Disease	hippocampal volume	SLC4A10 ABCB11 MCM5 DSCAML1 SDAD1	2.19e-03	297	90	5	EFO_0005035
Disease	Renal glomerular disease	INF2 PLCE1	2.23e-03	23	90	2	C0268731
Disease	Lymphoma, T-Cell, Cutaneous	NFKB2 ATM	2.23e-03	23	90	2	C0079773
Disease	Glomerulopathy Assessment	INF2 PLCE1	2.23e-03	23	90	2	C4521256
Disease	Immunologic Deficiency Syndromes	CACNA1C ATM	2.23e-03	23	90	2	C0021051

Protein segments in the cluster

Peptide	Gene	Start	Entry
LDKASIMRLAISFLR	EPAS1	51	Q99814
KERLLRISIRHMVKS	CACNA1E	461	Q15878
QRLVKRMTRFFTKLD	CHEK1	371	O14757
QVFAMARLRFLKLKR	ABCA6	836	Q8N139
ARKRTAKRAALMILT	HTR1E	131	P28566
RALALMKARVKSRLA	ACAD10	931	Q6JQN1
LLTKRLRKFGFRAML	ABCB11	826	O95342
KSRFAIRKIMLLEFS	AQR	56	O60306
RRLKFSQIELMLRKA	ANKRD22	176	Q5VYY1
MKKLRRTLSESFSRI	CDK14	16	O94921
MKTLRARFKKTELRL	ANKRD24	1	Q8TF21
RVRRFDLLKRILKMD	CFLAR	61	O15519
YAEMREKLRLRLTKR	FAM193A	811	P78312
LMMRRRFLSLKKTAI	ASPM	2276	Q8IZT6
ILRHKTSGKIRLLMR	RANBP2	1221	P49792
IRLLMRRDKTLKICA	RANBP1	86	P43487
LEFRKARSDMLLSRK	NIPSNAP2	151	O75323
LDKKLMSDLRRKRTA	INTS4	321	Q96HW7
KRTTFLKKHRMLGRL	KAT6B	621	Q8WYB5
RLFRVMRLVKLLSKG	CACNA1F	1296	O60840
EVRNALMKLLRRKIS	OR8D4	296	Q8NGM9
LMGLFEKRRFRKFLV	GDI2	131	P50395
DRREFIDLLKKMLTI	HIPK2	496	Q9H2X6
HLAAKLANRRMKRIL	NMS	96	Q5H8A3
MLSRIEKQLKRRFAI	MCM5	671	P33992
MIDRRLRKNLKSLII	ATCAY	256	Q86WG3
RAMLKRLLRIDSKCL	KAT5	486	Q92993
LFRRGSLLGSMKLRK	JPH1	211	Q9HDC5
VLKHSLLSFKRRRAM	DDX60L	1376	Q5H9U9
LLSFKRRRAMETLKL	DDX60L	1381	Q5H9U9
KLIFRFVRTLFKAMR	CCNYL2	191	Q5T2Q4
MNRRRKFLLASVLAL	DDIAS	1	Q8IXT1
RKSAKFRSISRSLML	IL16	11	Q14005
KLKTRNRESISLLMR	NCKAP1L	1076	P55160
LMRIFRVLKLARHST	KCNS1	346	Q96KK3
MKKFKRRLSLTLRGS	CDK17	1	Q00537
EAKMELKRRLSRKLS	PHACTR2	546	O75167
MLRKLRRSLRTVLES	PTGDR2	311	Q9Y5Y4
STMKAFRDLFLRALK	INF2	911	Q27J81
LRNKDMKGALRRLLA	OR2B11	296	Q5JQS5
VSFRAADIRRKLLML	ATM	916	Q13315
IMRILRILKLARHST	KCNB1	301	Q14721
FRLFRVMRLVKLLSR	CACNA1C	1376	Q13936
LTLSKIRSLKREMRK	CABLES1	511	Q8TDN4
FEIKKLALDRMRLST	CENPH	96	Q9H3R5
ELRLLETVKKFMALR	FER	21	P16591
LKRLRDAKSLAEMLI	DSCAML1	1621	Q8TD84
KLTRRNMSFRFIKRL	MARK3	611	P27448
RSFRSKRSKMLLEIN	IQCB1	326	Q15051
LKMERSFFLKKRRAD	KLHDC8A	256	Q8IYD2
AARRKARRLLKTVLM	S1PR4	241	O95977
KLTLSKIRSLKREMR	CABLES2	356	Q9BTV7
AMKRAALLEKRLRRE	CAMSAP2	1176	Q08AD1
AMKLRRVQKALRLDL	DRP2	406	Q13474
ARKVKRLHGMLRSLL	PKD1	3661	P98161
VLKTRMEERRLRAKL	RTF2	181	Q9BY42
MINLLKRFSSERKLL	VAC14	531	Q08AM6
ERRLLKKTMSGTFLL	STAT2	586	P52630
TSLVILMLARRKERL	TRPC4AP	691	Q8TEL6
SLIDKRIKLYMRRLL	TCP11L2	436	Q8N4U5
LLGFARLIKRMRKTQ	SLC16A12	456	Q6ZSM3
GLLELTRAVRKMRKF	PLCE1	1001	Q9P212
TMLERLASKRRKLVA	GANAB	451	Q14697
GFISVLKLFRMRSLR	SLC2A5	261	P22732
LMRIFRILKLARHST	KCNV2	381	Q8TDN2
RLMKMARLLARFLRE	TELO2	116	Q9Y4R8
LRMTFCKALILLRNK	SDAD1	96	Q9NVU7
SLATMIDRIKRHLKL	NIF3L1	261	Q9GZT8
KEDLLRRLKLVKMYR	SFR1	166	Q86XK3
ESQKLLRKKARRMLR	CNGB1	1071	Q14028
LRIRKENLTRLFEKM	SUPT6H	406	Q7KZ85
RSMRTVKRETLKLIS	XPO1	746	O14980
ALILILKRLDRMFNK	UNC80	2581	Q8N2C7
LEKDIATKMRLRALS	MIOS	386	Q9NXC5
LTKRDQMKLDSILRR	SPO11	331	Q9Y5K1
DAFNLLLEMKLKRRR	TRABD	41	Q9H4I3
KSLVASMRRFSLLKR	STX19	76	Q8N4C7
LRTLLRSSEMRRKLL	RFPL3S	21	P0C7P2
LKMLERSFSARRSKR	ZBTB41	241	Q5SVQ8
LVFVRKLMDLLFTKR	SLC4A10	1016	Q6U841
RMRVLSKAFSRLKTT	TCF21	91	O43680
KSLRRKRSMGFIIEI	PKHD1L1	3981	Q86WI1
RRKTMKLCRELSDLV	PLCH1	591	Q4KWH8
LRRLMKEKQRLSTSR	ZNF830	21	Q96NB3
MELKSFRTLRALRPL	SCN11A	1141	Q9UI33
LLFLFSRMLLVAKRR	PLEKHG2	336	Q9H7P9
LREKDRLLAMAVIRK	THAP11	296	Q96EK4
MLLREELLKSLANKR	ZFC3H1	626	O60293
RLLTAMRKRKLSQLH	SLFN5	806	Q08AF3
DKFLLFARRMDIRRI	LRP4	741	O75096
MLKARRELKALRIEA	MYO5B	896	Q9ULV0
LKKVMDLSIVRLRFS	NFKB2	181	Q00653