Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	regulation of cell-cell adhesion mediated by cadherin	ADAM19 PTPRU BMP6 TJP1	1.24e-05	21	144	4	GO:2000047
GeneOntologyBiologicalProcess	actin cytoskeleton organization	IQSEC3 XIRP1 SHROOM3 WIPF3 OBSCN TRIOBP ARHGAP17 SHROOM2 PTGER4 CDK10 SHROOM1 KISS1R TJP1 SORBS3 FGD1 DIAPH3 SAMD14 PALLD	1.28e-05	803	144	18	GO:0030036
GeneOntologyBiologicalProcess	actin filament-based process	IQSEC3 XIRP1 SHROOM3 WIPF3 OBSCN GATA4 TRIOBP ARHGAP17 SHROOM2 PTGER4 CDK10 SHROOM1 KISS1R TJP1 SORBS3 FGD1 DIAPH3 SAMD14 PALLD	2.00e-05	912	144	19	GO:0030029
GeneOntologyBiologicalProcess	positive regulation of cell-cell adhesion mediated by cadherin	ADAM19 PTPRU TJP1	5.28e-05	11	144	3	GO:2000049
GeneOntologyBiologicalProcess	actin filament organization	XIRP1 SHROOM3 WIPF3 TRIOBP ARHGAP17 SHROOM2 PTGER4 SHROOM1 KISS1R TJP1 SORBS3 DIAPH3 SAMD14	6.00e-05	509	144	13	GO:0007015
GeneOntologyCellularComponent	anchoring junction	XIRP1 SHROOM3 AOC1 COL17A1 CNTNAP1 LAMA1 OBSCN TRIOBP ARHGAP17 PTPRU THSD1 SHROOM2 FNDC1 SHROOM1 TJP1 SORBS3 FGFR4 TNS1 PALLD	3.82e-05	976	143	19	GO:0070161
GeneOntologyCellularComponent	cell-cell junction	XIRP1 SHROOM3 AOC1 COL17A1 CNTNAP1 LAMA1 OBSCN ARHGAP17 PTPRU SHROOM2 FNDC1 SHROOM1 TJP1 FGFR4	5.59e-05	591	143	14	GO:0005911
GeneOntologyCellularComponent	apical junction complex	SHROOM3 AOC1 CNTNAP1 ARHGAP17 SHROOM2 SHROOM1 TJP1	1.09e-04	158	143	7	GO:0043296
Domain	ASD1	SHROOM3 SHROOM2 SHROOM1	4.21e-07	3	141	3	PF08688
Domain	ASD1_dom	SHROOM3 SHROOM2 SHROOM1	4.21e-07	3	141	3	IPR014800
Domain	ASD1	SHROOM3 SHROOM2 SHROOM1	4.21e-07	3	141	3	PS51306
Domain	Shroom_fam	SHROOM3 SHROOM2 SHROOM1	1.68e-06	4	141	3	IPR027685
Domain	ASD2_dom	SHROOM3 SHROOM2 SHROOM1	1.68e-06	4	141	3	IPR014799
Domain	ASD2	SHROOM3 SHROOM2 SHROOM1	1.68e-06	4	141	3	PF08687
Domain	ASD2	SHROOM3 SHROOM2 SHROOM1	1.68e-06	4	141	3	PS51307
Domain	PLAC	ADAMTSL1 ADAMTS7 ADAMTS14 ADAMTSL4	1.10e-05	19	141	4	PS50900
Domain	PLAC	ADAMTSL1 ADAMTS7 ADAMTS14 ADAMTSL4	1.10e-05	19	141	4	IPR010909
Domain	Caskin_C	CASKIN2 CASKIN1	5.66e-05	2	141	2	IPR032117
Domain	DUF4795	C16orf96 QRICH2	5.66e-05	2	141	2	IPR032013
Domain	DUF4795	C16orf96 QRICH2	5.66e-05	2	141	2	PF16043
Domain	Caskin-tail	CASKIN2 CASKIN1	5.66e-05	2	141	2	PF16632
Domain	TSP_1	ADAMTSL1 THSD1 ADAMTS7 ADAMTS14 ADAMTSL4	1.13e-04	63	141	5	PF00090
Domain	TSP1	ADAMTSL1 THSD1 ADAMTS7 ADAMTS14 ADAMTSL4	1.31e-04	65	141	5	SM00209
Domain	TSP1_rpt	ADAMTSL1 THSD1 ADAMTS7 ADAMTS14 ADAMTSL4	1.31e-04	65	141	5	IPR000884
Domain	TSP1	ADAMTSL1 THSD1 ADAMTS7 ADAMTS14 ADAMTSL4	1.31e-04	65	141	5	PS50092
Domain	Pep_M12B_propep	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.09e-04	39	141	4	PF01562
Domain	Peptidase_M12B_N	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.09e-04	39	141	4	IPR002870
Domain	DISINTEGRIN_1	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.30e-04	40	141	4	PS00427
Domain	Reprolysin	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.30e-04	40	141	4	PF01421
Domain	ADAM_MEPRO	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.30e-04	40	141	4	PS50215
Domain	DISINTEGRIN_2	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.30e-04	40	141	4	PS50214
Domain	Peptidase_M12B	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.30e-04	40	141	4	IPR001590
Domain	Disintegrin_dom	ADAM19 ADAM8 ADAMTS7 ADAMTS14	2.54e-04	41	141	4	IPR001762
Domain	PH_dom-like	PRKD2 IQSEC3 OBSCN TRIOBP IRS1 EPS8L1 PLEKHM1 RALGPS1 NBEAL2 FGD1 TNS1	3.95e-04	426	141	11	IPR011993
Domain	Ig_I-set	ADAMTSL1 AXL OBSCN LRFN2 HMCN2 FGFR4 PALLD	6.06e-04	190	141	7	IPR013098
Domain	I-set	ADAMTSL1 AXL OBSCN LRFN2 HMCN2 FGFR4 PALLD	6.06e-04	190	141	7	PF07679
Domain	ADAM_spacer1	ADAMTS7 ADAMTS14 ADAMTSL4	6.68e-04	23	141	3	IPR010294
Domain	ADAM_spacer1	ADAMTS7 ADAMTS14 ADAMTSL4	6.68e-04	23	141	3	PF05986
Domain	Peptidase_M12B_ADAM-TS	ADAMTSL1 ADAMTS7 ADAMTS14	7.59e-04	24	141	3	IPR013273
Domain	ADAM_Cys-rich	ADAM19 ADAM8 ADAMTS14	1.08e-03	27	141	3	IPR006586
Domain	ACR	ADAM19 ADAM8 ADAMTS14	1.08e-03	27	141	3	SM00608
Domain	PH	PRKD2 IQSEC3 OBSCN TRIOBP IRS1 PLEKHM1 RALGPS1 FGD1	1.25e-03	278	141	8	SM00233
Domain	PH_DOMAIN	PRKD2 IQSEC3 OBSCN TRIOBP IRS1 PLEKHM1 RALGPS1 FGD1	1.28e-03	279	141	8	PS50003
Domain	PH_domain	PRKD2 IQSEC3 OBSCN TRIOBP IRS1 PLEKHM1 RALGPS1 FGD1	1.31e-03	280	141	8	IPR001849
Domain	PTB	EPS8L1 TNS1	1.54e-03	8	141	2	IPR013625
Domain	PTB	EPS8L1 TNS1	1.54e-03	8	141	2	PF08416
Domain	SAM/pointed	KIDINS220 CASKIN2 CASKIN1 TNKS SAMD14	1.95e-03	117	141	5	IPR013761
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 THSD1 ADAMTS7 ADAMTS14 ADAMTSL4	5.41e-06	39	93	5	M27417
Pathway	REACTOME_O_GLYCOSYLATION_OF_TSR_DOMAIN_CONTAINING_PROTEINS	ADAMTSL1 THSD1 ADAMTS7 ADAMTS14 ADAMTSL4	5.41e-06	39	93	5	MM15165
Pathway	REACTOME_SIGNALING_BY_LTK	ALKAL1 IRS1 LTK	5.86e-05	12	93	3	M48256
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTSL1 THSD1 ADAMTS7 ADAMTS14 ADAMTSL4	8.42e-05	68	93	5	M27303
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PRKD2 SHROOM3 HIVEP2 TBKBP1 NLRX1 GTSE1 OBSCN ARHGAP17 IRS1 ABCA7 PLEKHM1 RYR1 KMT2C EHBP1L1 MDN1 ADAMTS7 RALGPS1 NBEAL2 CASKIN1 SORBS3 SEC16A SAC3D1 RIPOR1 DTX2 LTK SNAPC4 HCFC1	3.80e-13	1105	152	27	35748872
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	MIIP ATXN2L SHROOM3 HIVEP2 HIPK4 GTSE1 ARHGAP17 IRS1 EPN2 ESYT2 MDN1 MAST4 SLF2 CASKIN2 TJP1 SEC16A ZNF286B MTCL1 PALLD CRTC2	1.35e-09	861	152	20	36931259
Pubmed	Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.	SHROOM3 SHROOM2 SHROOM1 TJP1	4.34e-08	9	152	4	17666436
Pubmed	E-cadherin interactome complexity and robustness resolved by quantitative proteomics.	ATXN2L SHROOM3 COL17A1 EPS8L1 EPN2 ESYT2 EHBP1L1 KIDINS220 CASKIN2 TJP1 CRYBG1 DIAPH3 JPT2 HCFC1	2.13e-07	565	152	14	25468996
Pubmed	A new standard nomenclature for proteins related to Apx and Shroom.	SHROOM3 SHROOM2 SHROOM1	3.26e-07	4	152	3	16615870
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CPAMD8 SHROOM3 HIVEP2 TBKBP1 MBP OBSCN TRIOBP SHROOM2 PLEKHM1 ZNF331 KMT2C ESYT2 USF3 LRFN2 KIDINS220 TJP1 SLC19A1 RALGPS1 KNDC1 RIPOR1 KATNIP SAP130	5.88e-07	1489	152	22	28611215
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PRKD2 GTSE1 ZNFX1 LARP4B SHROOM1 TJP1 SEC16A KNDC1 AGFG2 CRYBG1 CCAR2 RIPOR1 KATNIP TNKS DIAPH3 DEPDC7 CRTC2	3.26e-06	1038	152	17	26673895
Pubmed	Mammalian Nkx2.2+ perineurial glia are essential for motor nerve development.	MBP ISL2 TJP1	4.51e-06	8	152	3	24979729
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	ATXN2L GTSE1 BUD13 ISL2 ESYT2 MDN1 USP42 BRPF1 SORBS3 SEC16A CCAR2 SAC3D1 RIPOR1 SNAPC4	8.36e-06	774	152	14	15302935
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	IQSEC3 LRFN2 KIDINS220 TENM4 SEC16A CCAR2 RIPOR1 KATNIP MTCL1 MARCHF4	1.32e-05	407	152	10	12693553
Pubmed	Targeting TRIM37-driven centrosome dysfunction in 17q23-amplified breast cancer.	GTSE1 FAM193A TJP1 SEC16A CCAR2 DIAPH3 PALLD	1.75e-05	184	152	7	32908313
Pubmed	Kielin/chordin-like protein, a novel enhancer of BMP signaling, attenuates renal fibrotic disease.	KCP BMP7	1.90e-05	2	152	2	15793581
Pubmed	Bone morphogenetic proteins inhibit CD40L/IL-21-induced Ig production in human B cells: differential effects of BMP-6 and BMP-7.	BMP6 BMP7	1.90e-05	2	152	2	21898381
Pubmed	Dependence of nodal sodium channel clustering on paranodal axoglial contact in the developing CNS.	CNTNAP1 MBP	1.90e-05	2	152	2	10460258
Pubmed	The metalloprotease disintegrin ADAM8. Processing by autocatalysis is required for proteolytic activity and cell adhesion.	MBP ADAM8	1.90e-05	2	152	2	12372841
Pubmed	Genetic and functional analysis of SHROOM1-4 in a Chinese neural tube defect cohort.	SHROOM3 SHROOM2	1.90e-05	2	152	2	29423651
Pubmed	Murine osteogenic protein (OP-1): high levels of mRNA in kidney.	BMP6 BMP7	1.90e-05	2	152	2	1715687
Pubmed	[High expression of Circ-PALLD in heart failure is transcriptionally regulated by the transcription factor GATA4].	GATA4 PALLD	1.90e-05	2	152	2	37712274
Pubmed	Interaction between gonadotropin-releasing hormone and bone morphogenetic protein-6 and -7 signaling in LβT2 gonadotrope cells.	BMP6 BMP7	1.90e-05	2	152	2	21846488
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	IQSEC3 SHROOM3 CNTNAP1 TRIOBP ZNFX1 JAKMIP3 KCNA3 MDN1 TJP1 CASKIN1 SEC16A CCAR2 TNKS MTCL1 TNS1	2.28e-05	963	152	15	28671696
Pubmed	BMP/SMAD Pathway Promotes Neurogenesis of Midbrain Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem Cells.	ISL2 BMP6 BMP7 TJP1	2.31e-05	38	152	4	29321139
Pubmed	Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice.	TRIOBP KIDINS220 TENM4 TJP1	2.56e-05	39	152	4	24095980
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	ESYT2 KIDINS220 FAM193A MAST4 SEC16A MTCL1 PALLD	3.96e-05	209	152	7	36779422
Pubmed	Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects.	COL17A1 LAMA1 THSD1 PTGER4 BMP6 BMP7 FGFR4	4.08e-05	210	152	7	16537572
Pubmed	Genetic ablation reveals that the roof plate is essential for dorsal interneuron specification.	ISL2 BMP6 BMP7	4.40e-05	16	152	3	10693795
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	COL17A1 C1orf43 MBP EPN2 ESYT2 EHBP1L1 KIDINS220 CASKIN2 SLC19A1 NBEAL2 DIAPH3	4.43e-05	569	152	11	30639242
Pubmed	BMP4 substitutes for loss of BMP7 during kidney development.	BMP6 BMP7	5.68e-05	3	152	2	16154126
Pubmed	AXL phosphorylates and up-regulates TNS2 and its implications in IRS-1-associated metabolism in cancer cells.	AXL IRS1	5.68e-05	3	152	2	30419905
Pubmed	Tumor necrosis factor (TNF) interferes with insulin signaling through the p55 TNF receptor death domain.	IRS1 SMPD1	5.68e-05	3	152	2	15721320
Pubmed	A bone morphogenetic protein subfamily: chromosomal localization of human genes for BMP5, BMP6, and BMP7.	BMP6 BMP7	5.68e-05	3	152	2	1427904
Pubmed	Bone morphogenetic protein-2, -6, and -7 differently regulate osteogenic differentiation of human periodontal ligament stem cells.	BMP6 BMP7	5.68e-05	3	152	2	23853066
Pubmed	Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation.	MBP IRS1	5.68e-05	3	152	2	9535915
Pubmed	Immunohistochemical analysis revealed the expression of bone morphogenetic proteins-4, 6, 7, and 9 in human induced membrane samples treated with the Masquelet technique.	BMP6 BMP7	5.68e-05	3	152	2	35033126
Pubmed	CASK participates in alternative tripartite complexes in which Mint 1 competes for binding with caskin 1, a novel CASK-binding protein.	CASKIN2 CASKIN1	5.68e-05	3	152	2	12040031
Pubmed	A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene.	FOXO3B ZNF286B	5.68e-05	3	152	2	29925039
Pubmed	Bone morphogenetic proteins are overexpressed in the bone marrow of primary myelofibrosis and are apparently induced by fibrogenic cytokines.	BMP6 BMP7	5.68e-05	3	152	2	18349123
Pubmed	Deorphanization of the human leukocyte tyrosine kinase (LTK) receptor by a signaling screen of the extracellular proteome.	ALKAL1 LTK	5.68e-05	3	152	2	25331893
Pubmed	Structure of Shroom domain 2 reveals a three-segmented coiled-coil required for dimerization, Rock binding, and apical constriction.	SHROOM3 SHROOM1	5.68e-05	3	152	2	22493320
Pubmed	Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.	BMP6 BMP7	5.68e-05	3	152	2	2263636
Pubmed	Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.	CASKIN2 CASKIN1	5.68e-05	3	152	2	31727973
Pubmed	Genetic determinants of disease progression in Alzheimer's disease.	ADAM19 PIGQ	5.68e-05	3	152	2	25114068
Pubmed	Bone morphogenetic proteins 4, 6, and 7 are up-regulated in mouse spinal cord during experimental autoimmune encephalomyelitis.	BMP6 BMP7	5.68e-05	3	152	2	17722066
Pubmed	Growth differentiation factor 3 is induced by bone morphogenetic protein 6 (BMP-6) and BMP-7 and increases luteinizing hormone receptor messenger RNA expression in human granulosa cells.	BMP6 BMP7	5.68e-05	3	152	2	22305102
Pubmed	Synergistic effects of BMP-2, BMP-6 or BMP-7 with human plasma fibronectin onto hydroxyapatite coatings: A comparative study.	BMP6 BMP7	5.68e-05	3	152	2	28434979
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	XIRP1 SHROOM2 PLEKHM1 STPG3 KMT2C LTK KLHDC10	7.86e-05	233	152	7	37704626
Pubmed	Dorsal and lateral fates in the mouse neural tube require the cell-autonomous activity of the open brain gene.	ISL2 BMP6 BMP7	8.83e-05	20	152	3	11071781
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	PLEKHM1 MDN1 MAST4 RALGPS1 SEC16A	9.69e-05	104	152	5	9205841
Pubmed	The matrisome: in silico definition and in vivo characterization by proteomics of normal and tumor extracellular matrices.	ADAMTSL1 ADAM19 LAMA1 HMCN2 VWA5A HCFC1	9.74e-05	167	152	6	22159717
Pubmed	Immunohistochemical localization of bone morphogenetic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation.	BMP6 BMP7	1.13e-04	4	152	2	17262821
Pubmed	Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins.	SHROOM2 SHROOM1	1.13e-04	4	152	2	16684770
Pubmed	Augmentor α and β (FAM150) are ligands of the receptor tyrosine kinases ALK and LTK: Hierarchy and specificity of ligand-receptor interactions.	ALKAL1 LTK	1.13e-04	4	152	2	26630010
Pubmed	Structural basis of cytokine-mediated activation of ALK family receptors.	ALKAL1 LTK	1.13e-04	4	152	2	34646012
Pubmed	Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation.	BMP6 BMP7	1.13e-04	4	152	2	17244894
Pubmed	Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation.	AXL MBP	1.13e-04	4	152	2	9395235
Pubmed	FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.	ALKAL1 LTK	1.13e-04	4	152	2	26418745
Pubmed	Fgd1, the Cdc42 GEF responsible for Faciogenital Dysplasia, directly interacts with cortactin and mAbp1 to modulate cell shape.	AOC1 FGD1	1.13e-04	4	152	2	12913069
Pubmed	Primordial germ cell proliferation is impaired in Fused Toes mutant embryos.	GATA4 BMP6 BMP7	1.19e-04	22	152	3	20969841
Pubmed	T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis.	GATA4 ISL2 BMP7	1.19e-04	22	152	3	15843407
Pubmed	Genomic variants in an inbred mouse model predict mania-like behaviors.	OBSCN ZNFX1 FNDC1	1.36e-04	23	152	3	29768498
Pubmed	The PHLPP1 N-Terminal Extension Is a Mitotic Cdk1 Substrate and Controls an Interactome Switch.	ATXN2L GTSE1 KIDINS220 TJP1 SEC16A DIAPH3 HCFC1	1.41e-04	256	152	7	33397691
Pubmed	Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.	ADAM19 EPS8L1 ADAM8	1.55e-04	24	152	3	25825872
Pubmed	Signaling through BMP type 1 receptors is required for development of interneuron cell types in the dorsal spinal cord.	ISL2 BMP6 BMP7	1.75e-04	25	152	3	15469980
Pubmed	Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot.	BMP6 BMP7	1.88e-04	5	152	2	14623234
Pubmed	Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.	BMP6 BMP7	1.88e-04	5	152	2	11437450
Pubmed	Expression of bone morphogenetic proteins in human metastatic prostate and breast cancer.	BMP6 BMP7	1.88e-04	5	152	2	15861517
Pubmed	Erythroferrone inhibits the induction of hepcidin by BMP6.	BMP6 BMP7	1.88e-04	5	152	2	30097509
Pubmed	Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains.	GRID2 EPN2	1.88e-04	5	152	2	9813051
Pubmed	Ermin, a myelinating oligodendrocyte-specific protein that regulates cell morphology.	CNTNAP1 MBP	1.88e-04	5	152	2	16421295
Pubmed	Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.	XIRP1 NPIPB11 WIPF3 GATA4 KMT2C ESYT2 EHBP1L1 MDN1 USP42 CASKIN2 MTCL1	2.37e-04	689	152	11	36543142
Pubmed	Pax6-dependent Shroom3 expression regulates apical constriction during lens placode invagination.	SHROOM3 TJP1	2.81e-04	6	152	2	20081189
Pubmed	Bone morphogenetic protein signaling in the developing kidney: present and future.	BMP6 BMP7	2.81e-04	6	152	2	18331343
Pubmed	Nbeal2 interacts with Dock7, Sec16a, and Vac14.	NBEAL2 SEC16A	2.81e-04	6	152	2	29187380
Pubmed	Expression patterns of bone morphogenetic proteins (Bmps) in the developing mouse tooth suggest roles in morphogenesis and cell differentiation.	BMP6 BMP7	2.81e-04	6	152	2	9415424
Pubmed	BMP mRNA and protein expression in the developing mouse olfactory system.	BMP6 BMP7	2.81e-04	6	152	2	12210138
Pubmed	Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects in BMP7 deficient embryos.	BMP6 BMP7	2.81e-04	6	152	2	9056639
Pubmed	Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9.	COL17A1 ADAM8	2.81e-04	6	152	2	19574220
Pubmed	Regulation of ovarian function by the TGF-beta superfamily and follistatin.	BMP6 BMP7	2.81e-04	6	152	2	12887271
Pubmed	Colocalization of BMP 7 and BMP 2 RNAs suggests that these factors cooperatively mediate tissue interactions during murine development.	BMP6 BMP7	2.81e-04	6	152	2	7605753
Pubmed	Osteocyte control of bone formation via sclerostin, a novel BMP antagonist.	BMP6 BMP7	2.81e-04	6	152	2	14633986
Pubmed	Effect of BMPs and Wnt3a co-expression on the osteogenetic capacity of osteoblasts.	BMP6 BMP7	2.81e-04	6	152	2	27633082
Pubmed	Expression of the tight junction protein ZO-1 in the olfactory system: presence of ZO-1 on olfactory sensory neurons and glial cells.	MBP TJP1	2.81e-04	6	152	2	8201022
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	CACNA1B LAMA1 RYR1 KMT2C KIDINS220 KCNA3	3.20e-04	208	152	6	33230847
Pubmed	O-fucosylation of thrombospondin type 1 repeats restricts epithelial to mesenchymal transition (EMT) and maintains epiblast pluripotency during mouse gastrulation.	ADAMTSL1 ADAMTS7 ADAMTS14 ADAMTSL4	3.35e-04	75	152	4	20637190
Pubmed	Binding of USP4 to cortactin enhances cell migration in HCT116 human colon cancer cells.	ATXN2L ESYT2 TJP1 JPT2 HCFC1	3.51e-04	137	152	5	37039823
Pubmed	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.	ATXN2L GTSE1 LARP4B SORBS3 SEC16A MTCL1 JPT2 PALLD HCFC1	3.90e-04	503	152	9	16964243
Pubmed	Type I receptor binding of bone morphogenetic protein 6 is dependent on N-glycosylation of the ligand.	BMP6 BMP7	3.93e-04	7	152	2	18070108
Pubmed	Identification and characterization of a novel nuclear protein complex involved in nuclear hormone receptor-mediated gene regulation.	CCAR2 HCFC1	3.93e-04	7	152	2	19131338
Pubmed	Survival of Hoxa13 homozygous mutants reveals a novel role in digit patterning and appendicular skeletal development.	BMP6 BMP7	3.93e-04	7	152	2	20034107
Pubmed	Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.	AXL LTK	3.93e-04	7	152	2	19815557
Pubmed	Limbiting outgrowth: BMPs as negative regulators in limb development.	BMP6 BMP7	3.93e-04	7	152	2	10462412
Pubmed	A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4.	BMP6 BMP7	3.93e-04	7	152	2	7811286
Pubmed	Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP.	BMP6 BMP7	3.93e-04	7	152	2	9786991
Pubmed	Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development.	GATA4 TJP1	3.93e-04	7	152	2	16364283
Pubmed	Shroom3 functions downstream of planar cell polarity to regulate myosin II distribution and cellular organization during neural tube closure.	SHROOM3 TJP1	3.93e-04	7	152	2	25596276
Pubmed	FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code.	ISL2 FGFR4	3.93e-04	7	152	2	16772167
Pubmed	GPR84 Is Essential for the Taste of Medium Chain Saturated Fatty Acids.	MBP PTPRU	3.93e-04	7	152	2	33941648
Pubmed	The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.	IRS1 PTPRU	3.93e-04	7	152	2	11781100
Pubmed	BMP7 functions predominantly as a heterodimer with BMP2 or BMP4 during mammalian embryogenesis.	BMP6 BMP7	3.93e-04	7	152	2	31566563
Pubmed	Putative tyrosine kinases expressed in K-562 human leukemia cells.	AXL FGFR4	3.93e-04	7	152	2	2247464
Pubmed	Adhesion protein VSIG1 is required for the proper differentiation of glandular gastric epithelia.	GATA4 TJP1	3.93e-04	7	152	2	21991385
Interaction	TOP3B interactions	PRKD2 SHROOM3 HIVEP2 TBKBP1 NLRX1 GTSE1 OBSCN ARHGAP17 IRS1 ABCA7 PLEKHM1 RYR1 KMT2C LARP4B EHBP1L1 MDN1 ADAMTS7 RALGPS1 NBEAL2 CASKIN1 SORBS3 SEC16A SAC3D1 RIPOR1 DTX2 LTK SNAPC4 ADAMTSL4 HCFC1	9.94e-07	1470	149	29	int:TOP3B
Interaction	YWHAH interactions	MIIP PRKD2 ATXN2L TICRR SHROOM3 HIVEP2 GTSE1 ARHGAP17 IRS1 EPN2 ESYT2 SHROOM1 MAST4 SLF2 CASKIN2 TJP1 SEC16A ZNF286B CCAR2 MTCL1 MARCHF4 PALLD CRTC2	6.24e-06	1102	149	23	int:YWHAH
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 OBSCN LRFN2 HMCN2 FGFR4 PALLD	1.27e-04	161	87	6	593
GeneFamily	ADAMTS like	ADAMTSL1 ADAMTSL4	4.73e-04	7	87	2	947
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PRKD2 TRIOBP IRS1 PLEKHM1 RALGPS1 FGD1	4.77e-04	206	87	6	682
GeneFamily	Sterile alpha motif domain containing	CASKIN2 CASKIN1 TNKS SAMD14	8.57e-04	88	87	4	760
GeneFamily	Receptor Tyrosine Kinases\|CD molecules	AXL FGFR4 LTK	9.35e-04	40	87	3	321
GeneFamily	Fibronectin type III domain containing	AXL OBSCN PTPRU FNDC1 LRFN2	1.05e-03	160	87	5	555
GeneFamily	Bone morphogenetic proteins\|Astacins	BMP6 BMP7	1.22e-03	11	87	2	455
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS7 ADAMTS14	3.71e-03	19	87	2	50
Coexpression	GSE40274_CTRL_VS_FOXP3_AND_PBX1_TRANSDUCED_ACTIVATED_CD4_TCELL_UP	PRKD2 HIVEP2 EPS8L1 KIDINS220 TENM4 MAST4 ADAMTS14 HDAC10	5.65e-06	165	152	8	M9105
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	PRKD2 CENPT NLRX1 GTSE1 ALDH1L1 ADAM8 CITED4 ADAMTS7 RALGPS1 NBEAL2 ZNF764 SAC3D1 RIPOR1 DEPDC7	1.37e-05	611	152	14	M1106
Coexpression	GSE39022_LN_VS_SPLEEN_DC_DN	HIVEP2 MBP KMT2C ESYT2 KIDINS220 MDN1 ZNF764 ADAMTSL4	2.13e-05	198	152	8	M9018
Coexpression	GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP	PRKD2 CENPT NLRX1 GTSE1 ALDH1L1 ADAM8 CITED4 ADAMTS7 RALGPS1 NBEAL2 ZNF764 SAC3D1 RIPOR1 DEPDC7	2.58e-05	647	152	14	MM981
ToppCell	LPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 AXL CNTNAP1 GRID2 IRS1 FNDC1 TENM4 PALLD	1.93e-07	179	152	8	02c90d8306016365ed811f0c63cfb3ac7b85464c
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAM19 ALKAL1 AXL IRS1 BMP6 KISS1R MTCL1 TNS1	2.48e-07	185	152	8	e58a009aaf342be019a909747b1895d5987d4daf
ToppCell	10x5'-Lung-Mast\|Lung / Manually curated celltypes from each tissue	ENPP3 RHEX BMP7 MAST4 ADAMTS7 VWA5A MTCL1 SAMD14	2.70e-07	187	152	8	f8ac5ca5cbe9c6f3d8c0fffc20fe08ca1aea43c0
ToppCell	10x5'-Lung-Mast-Mast_cells\|Lung / Manually curated celltypes from each tissue	ENPP3 RHEX BMP7 MAST4 ADAMTS7 VWA5A MTCL1 SAMD14	2.70e-07	187	152	8	da275d2c774b3e6a8ed77f777dd0676ecf2ddd2c
ToppCell	LAM-Epithelial-AT1\|Epithelial / Condition, Lineage and Cell class	MAB21L4 UPK3B ABCA7 SLC19A1 NBEAL2 FAM167A TNS1 PALLD	3.17e-07	191	152	8	3457e15d1e9b36a78363d46b320c4ec46b40290a
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	DPH1 SHROOM3 ADAM19 MBP DEPDC7 ADAMTSL4 SHISA8	3.26e-07	130	152	7	0a6b87635e650df431a88f2e6396abead84d901d
ToppCell	Epithelial_cells-AT1-AT2_cells\|Epithelial_cells / lung cells shred on cell class, cell subclass, sample id	MAB21L4 UPK3B ABCA7 NBEAL2 FAM167A DIAPH3 TNS1 PALLD	4.16e-07	198	152	8	fbc46b20bcd44f2083170aacbc6f5dd00fba685c
ToppCell	390C-Lymphocytic-NK_cells-NK_cell_D2\|NK_cells / Donor, Lineage, Cell class and subclass (all cells)	WIPF3 KCP PSMG3-AS1 CITED4 KCNA3 ADAMTSL4 SHISA8	1.07e-06	155	152	7	216a240bfb82cdefc59e2f342689dbaaacb7c184
ToppCell	facs-Marrow-T-cells-24m-Myeloid-CD4+_macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL17A1 C16orf96 RYR1 TENM4 FGFR4 TNS1 PALLD	2.23e-06	173	152	7	ca3d2a9562734f76127e3e7d54c10b63e95141bb
ToppCell	facs-Marrow-T-cells-24m-Myeloid-macrophage\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COL17A1 C16orf96 RYR1 TENM4 FGFR4 TNS1 PALLD	2.23e-06	173	152	7	19a9e10885173d7712996be8660a3a5a7a9aa39f
ToppCell	10x5'-GI_small-bowel-Mast\|GI_small-bowel / Manually curated celltypes from each tissue	ENPP3 RHEX BMP7 ADAMTS7 VWA5A TNS1 PALLD	2.31e-06	174	152	7	e94c980b25edfd0e8598c416828801fcc00e8ead
ToppCell	10x5'-GI_small-bowel-Mast-Mast_cells\|GI_small-bowel / Manually curated celltypes from each tissue	ENPP3 RHEX BMP7 ADAMTS7 VWA5A TNS1 PALLD	2.31e-06	174	152	7	05525bf0a2bde2be4f7c147b17a24530ce8819e0
ToppCell	LPS_only-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 GRID2 IRS1 ST6GAL2 FNDC1 TENM4 PALLD	3.23e-06	183	152	7	12daaea821e49bc94a01e2496331e92a80d27339
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 UPK3B ABCA7 FNDC1 NBEAL2 FAM167A PALLD	3.35e-06	184	152	7	c7073d1b2c4fdb154d87678b92a0629c02116972
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|343B / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 UPK3B ABCA7 FNDC1 NBEAL2 FAM167A TNS1	3.35e-06	184	152	7	cb15d6bae52c5ec251c2235859dc7e65f630ae23
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 UPK3B ABCA7 FNDC1 NBEAL2 FAM167A PALLD	3.35e-06	184	152	7	1ed558a88215b248431c524ea16f13d9022ae98c
ToppCell	343B-Epithelial_cells-Epithelial-I_(AT1)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	MAB21L4 UPK3B ABCA7 FNDC1 NBEAL2 FAM167A TNS1	3.35e-06	184	152	7	bde4eaabd3e9bdaed23867d23a919b9d84b52d4b
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 GRID2 IRS1 ST6GAL2 FNDC1 TENM4 PALLD	3.47e-06	185	152	7	3b2dfc8f4c87be516265dbecfc251276034d0efd
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MIIP ENPP3 ADAM8 RHEX ADAMTS7 VWA5A TNS1	3.60e-06	186	152	7	de55471dd5c842026b409cfebf67fe32f079a011
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1 PALLD	3.60e-06	186	152	7	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	Mesenchymal-airway_smooth_muscle_cell\|World / Lineage, Cell type, age group and donor	ADAM19 ALKAL1 AXL IRS1 FNDC1 MTCL1 PALLD	4.14e-06	190	152	7	645e56b02edc3702c7db917b8ecd5eed0decaf71
ToppCell	LAM-Epithelial-AT1\|LAM / Condition, Lineage and Cell class	SHROOM3 MAB21L4 UPK3B PTPRU ABCA7 FAM167A TNS1	4.28e-06	191	152	7	66875b2ec2c510489407f3e433a90cdf74a15094
ToppCell	Ciliated-cil-3\|World / Class top	AOC1 C1orf43 ADAM8 FAM167A KNDC1 TMC5 LRRC36	4.43e-06	192	152	7	4989ebb8812b8af1870599acd932849122c05a29
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 SHROOM3 MBP KCP NBEAL2 CRYBG1 TMC5	4.74e-06	194	152	7	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CPAMD8 SHROOM3 MBP KCP NBEAL2 CRYBG1 TMC5	4.74e-06	194	152	7	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAB21L4 UPK3B ABCA7 NBEAL2 FAM167A DIAPH3 TNS1	5.07e-06	196	152	7	eb68f7954e7c2f86d05e740e95b6e74805a6053f
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG\|World / Primary Cells by Cluster	DIPK1C SHROOM3 LAMA1 BMP7 FNDC1 MAST4 PALLD	5.25e-06	197	152	7	61749ccafeb938c310cff1de5ff924a1c794325a
ToppCell	Non-neuronal-Non-dividing-Radial_Glia-tRG-25\|World / Primary Cells by Cluster	DIPK1C SHROOM3 LAMA1 BMP7 FNDC1 MAST4 PALLD	5.25e-06	197	152	7	9d4ffa3680f92c91d0a081f9a8ec5ebfec6bdcf6
ToppCell	AT1-AT2_cells\|World / lung cells shred on cell class, cell subclass, sample id	SHROOM3 MAB21L4 UPK3B ABCA7 TJP1 FAM167A TNS1	5.42e-06	198	152	7	a5b3617ea2ed4bffba59edcf6284799c2b3bbb29
ToppCell	(7)_Epithelial_cells-(7)_Epithelial-I_(AT1)\|(7)_Epithelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)	MAB21L4 UPK3B ABCA7 ST6GAL2 NBEAL2 FAM167A PALLD	5.61e-06	199	152	7	5a002d49a8b84c158f7b4d7a3e78e6a937757bb7
ToppCell	Parenchymal-10x3prime_v2-Epithelial-Epi_alveolar-AT1\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	MAB21L4 UPK3B ABCA7 SLC19A1 NBEAL2 FAM167A DIAPH3	5.79e-06	200	152	7	3d51aebf626dd4656ab4aac8a20d761b8062c42d
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O2-Trf\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADAM19 MBP CCDC187 FGFR4 DEPDC7 SHISA8	6.21e-06	132	152	6	12d2765908d5ef36f96ca3b54643a8859f807b93
ToppCell	Entopeduncular-Macroglia-OLIGODENDROCYTE-O2\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	ADAM19 MBP CCDC187 FGFR4 DEPDC7 SHISA8	6.21e-06	132	152	6	e0733a41d2281d25786b9fd1da629f2e58f15b67
ToppCell	LPS-IL1RA-Hematopoietic_Mast-Mast_cells-T-cells\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B IQSEC3 ADAM19 PTGER4 RHEX DIAPH3	8.01e-06	138	152	6	10c263c58b83a018791f77098f18927d904cb13b
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	KCP BUD13 C10orf95 BMP7 CBX7 DIAPH3	9.44e-06	142	152	6	199a0a1024b6cc446f5ca1f277846a2bdb227a9f
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast-Mast_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B IQSEC3 ENPP3 PTGER4 RHEX DIAPH3	1.11e-05	146	152	6	a5c84ad44d6ffb25028a4fd5454fd5de81b16a5e
ToppCell	LPS-IL1RA+antiTNF-Hematopoietic_Mast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B IQSEC3 ENPP3 PTGER4 RHEX DIAPH3	1.11e-05	146	152	6	8133037881c15e75637fc616091a7055488dd5fc
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	ADAM19 SHROOM2 SLC19A1 SORBS3 FGFR4 LTK	1.15e-05	147	152	6	9566398275cad79223db90ffe640830acf2db864
ToppCell	LPS_only-Hematopoietic_Mast-Mast_cells\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B IQSEC3 ADAM19 ENPP3 PTGER4 RHEX	1.29e-05	150	152	6	7290e9a812b1b2f919e67ccde0acf52687ab138f
ToppCell	LPS_only-Hematopoietic_Mast\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	CACNA1B IQSEC3 ADAM19 ENPP3 PTGER4 RHEX	1.29e-05	150	152	6	2c5078a1f769ba8153dee756b53d28eb7b434a96
ToppCell	NS-critical-d_16-33-Myeloid-Mast_cell\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	IQSEC3 ENPP3 RHEX ADAMTS7 MTCL1 ADAMTS14	1.86e-05	160	152	6	c61869d9dbba250270e59366e15af204e5b4395d
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ADAM19 AOC1 ABCA7 RHEX GPR153 CRYBG1	1.93e-05	161	152	6	cd41abb7ae659d3d314281783a0aaad562b26037
ToppCell	AT1_cells-IPF_01\|World / lung cells shred on cell class, cell subclass, sample id	MAB21L4 UPK3B ABCA7 FNDC1 SLC19A1 DIAPH3	2.00e-05	162	152	6	ae2ba4f21f6f6c512006fa531d670b88be7c04c9
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DPH1 BMP6 ADAMTS7 FGFR4 LRRC36	2.07e-05	97	152	5	2cd5cafdf0a9a468baaafd4613d790fc048ee53e
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DPH1 BMP6 ADAMTS7 FGFR4 LRRC36	2.07e-05	97	152	5	adda7a49b7754ed110e212346768bf52107c26fc
ToppCell	Frontal_cortex-Endothelial-ENDOTHELIAL_TIP-Dcn_1-Dcn_1_2-Endothelial_Tip.Dcn.Coch_(Coch)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	DPH1 BMP6 ADAMTS7 FGFR4 LRRC36	2.07e-05	97	152	5	6d865ec3a413f595de17e0a5f8c61666ebb3e252
ToppCell	critical-Myeloid-Mast_cell\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ENPP3 RHEX ADAMTS7 VWA5A MTCL1 DEPDC7	2.21e-05	165	152	6	34a1cc6ccd46c059354e8fbde1ac69f202695a4e
ToppCell	moderate-Myeloid-Mast_cell\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1	2.29e-05	166	152	6	c3835b424c63bf11a4e2c47635dc3787fc4a637a
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|World / disease group, cell group and cell class (v2)	AXL RHEX BMP7 TENM4 MTCL1 LTK	2.37e-05	167	152	6	bf08f17965a4dd03f371b4ed0ab0d5e62ed61307
ToppCell	mild_COVID-19_(asymptomatic)-pDC\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	AXL RHEX BMP7 TENM4 MTCL1 LTK	2.45e-05	168	152	6	968405ea56f7d001ef83ff9274610923c3b2d55d
ToppCell	356C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNFX1 ADAM8 QRICH2 PSMG3-AS1 HMCN2 JPT2	2.53e-05	169	152	6	0425d2580ed325178f522c0093ff4623de6ce7a8
ToppCell	356C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	ZNFX1 ADAM8 QRICH2 PSMG3-AS1 HMCN2 JPT2	2.53e-05	169	152	6	fec669968a77060bd77ee8695034e35a642c984f
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_I_pneumocyte-AT1-AT1_L.0.5.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	SHROOM3 MAB21L4 UPK3B ABCA7 NBEAL2 FAM167A	2.53e-05	169	152	6	cd16e8462ee09877be962fbd9a3badcb825820b0
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_progenitor_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	KLHDC9 BMP7 CITED4 TENM4 ADAMTS7 FGFR4	2.62e-05	170	152	6	ba4ba66b624089ed50a9083176386c7941b4c7a3
ToppCell	Control-Myeloid-Mast\|Control / Disease state, Lineage and Cell class	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1	2.62e-05	170	152	6	9a14deb7f7cd4a49c217eba4023f7bf1dec6c902
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|Endothelial_cells / Location, Cell class and cell subclass	AXL MBP ADAM8 PTGER4 ZNF331 KCNA3	2.71e-05	171	152	6	dcb6c41980008d0b9eeb54999faff77311554976
ToppCell	Control-Myeloid-Mast\|World / Disease state, Lineage and Cell class	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1	2.71e-05	171	152	6	ed8e61d524f4cddc6084b261175df54d2a64a60f
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 ST6GAL2 RHEX TENM4 DIAPH3 JPT2	2.80e-05	172	152	6	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	LAMA1 ST6GAL2 RHEX TENM4 DIAPH3 JPT2	2.80e-05	172	152	6	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	11.5-Distal-Mesenchymal-Mesenchyme_SERPINF1-high\|Distal / Age, Tissue, Lineage and Cell class	UPK3B GATA4 C10orf95 EPS8L1 ST6GAL2 FNDC1	2.89e-05	173	152	6	6989c9cebcd81eccceac7e5a86152676ee959386
ToppCell	BL-critical-LOC-Lymphoid-PC\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	TICRR GTSE1 ISL2 RHEX MTCL1 DIAPH3	2.89e-05	173	152	6	90700a876d997f7c0f7b3899dffcda7fdafee547
ToppCell	facs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DIPK1C AXL ENPP3 KCP TRIOBP FAM167A	2.98e-05	174	152	6	1d157f7a919c8246e83d8060d2a0017c6c781ef3
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIVEP2 MAST4 ADAMTS7 GPR153 FAM167A SAMD14	3.08e-05	175	152	6	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	facs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l6-17\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CACNA1B NLRX1 CASKIN1 CCAR2 MARCHF4 PLAAT5	3.28e-05	177	152	6	8abdf1d970b2f15e17e185f3e612dd5065c88757
ToppCell	droplet-Fat-Scat-21m-Mesenchymal-nan\|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TICRR COL17A1 OBSCN ZSCAN10 CCAR2 PLAAT5	3.39e-05	178	152	6	5fc9f41609735b972a2cd0830182d13742cd5bf5
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 UPK3B ST6GAL2 TJP1 DIAPH3 TMC5	3.50e-05	179	152	6	4f6ca313b78aa93557937a046c44dcf8bcc9963c
ToppCell	390C-Lymphocytic-ILC-ILC-1\|390C / Donor, Lineage, Cell class and subclass (all cells)	SHROOM3 HIVEP2 NLRX1 ARHGAP17 KCNA3 DTX2	3.50e-05	179	152	6	e7045e27f0eb88f552b31c04b56d78e5ccd7a36c
ToppCell	343B-Lymphocytic-NK_cells-NK_cell_A2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ARHGAP17 ABCA7 ZBTB45 FAM193A RIPOR1 KLHDC10	3.61e-05	180	152	6	62511d76d24b836839c3dcc2bf30485ffe9401e2
ToppCell	AT1_cells-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	MAB21L4 UPK3B ABCA7 NBEAL2 FAM167A TNS1	3.61e-05	180	152	6	2d52cb5f77dde0e3dccac1333d4ec67ec680fcb2
ToppCell	COVID-19-Heart-CM_3\|Heart / Disease (COVID-19 only), tissue and cell type	XIRP1 ADAM19 OBSCN KCP MAST4 PALLD	3.84e-05	182	152	6	287fcc3897ae08841f6f85ae6c9cef16f75b1dd1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UPK3B ALDH1L1 BMP7 SHROOM1 CRYBG1 MTCL1	3.84e-05	182	152	6	678eadd57e7e830fc2bf9fd35616d3badce01705
ToppCell	COPD-Myeloid-Mast\|World / Disease state, Lineage and Cell class	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1	3.84e-05	182	152	6	68a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-papillary_tips_cell-Papillary_Tip_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	UPK3B ALDH1L1 BMP7 SHROOM1 CRYBG1 MTCL1	3.84e-05	182	152	6	8d1229fa5aa6e2e38f2ac6fe4f4dc89752fe9344
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 GRID2 ST6GAL2 FNDC1 TENM4 PALLD	3.95e-05	183	152	6	7eae9b3b4d1c9b135fa7cff348393d4adec474b4
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	ADAM19 ALKAL1 IRS1 MTCL1 MARCHF4 PALLD	3.95e-05	183	152	6	e84539978ab4de42e19186aed00f24bb50cbc21f
ToppCell	IPF-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1	4.08e-05	184	152	6	7326a16d7d3ae41b8c9d2beaec7f977b374f3469
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-3\|TCGA-Lung / Sample_Type by Project: Shred V9	CACNA1B TICRR WIPF3 BMP7 TENM4 MTCL1	4.08e-05	184	152	6	ea4ccebe2d54279fcc517e4f0bfa652b91a808bb
ToppCell	IPF-Myeloid-Mast\|World / Disease state, Lineage and Cell class	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1	4.08e-05	184	152	6	7aefa182acad5a53c730945fec85329d7168606a
ToppCell	IPF-Myeloid-Mast\|IPF / Disease state, Lineage and Cell class	ENPP3 RHEX MAST4 ADAMTS7 VWA5A MTCL1	4.08e-05	184	152	6	c3baf21f10b45cf91ac99997a59f353bcf3de8b7
ToppCell	droplet-Kidney-KIDNEY-1m-Epithelial-Pecam____kidney_capillary_endothelial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HIPK4 CNTNAP1 WIPF3 QRICH2 ADAMTS7 GPR153	4.08e-05	184	152	6	1c857126c0ea0671f0d60b048efca288d348d653
ToppCell	PBMC-Mild-cDC_9\|Mild / Compartment, Disease Groups and Clusters	CACNA1B ADAM19 WIPF3 BMP6 LARP4B TJP1	4.08e-05	184	152	6	2e0c9a2c40c892a2d435eafb31f1f838de9baf15
ToppCell	Smart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_granulocytic-mast_cell\|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	MIIP ENPP3 RHEX ADAMTS7 VWA5A TNS1	4.20e-05	185	152	6	3fafb1d36c5f98a29d20a5ce5192c83d6f603514
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 MAB21L4 TJP1 NBEAL2 DIAPH3 TMC5	4.20e-05	185	152	6	1c222f7285d6e3dae0354dc7e853ddc0ea55e63e
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 GRID2 IRS1 FNDC1 TENM4 PALLD	4.20e-05	185	152	6	6712512100ccef456d2e2bd201d0987986c92ac9
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 GRID2 IRS1 FNDC1 MTCL1 PALLD	4.33e-05	186	152	6	6add08d4ca019ff2864acdd5ec2c66a59a574591
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CPAMD8 SHROOM3 ADAMTSL1 UPK3B NBEAL2 DIAPH3	4.46e-05	187	152	6	4ae7465174e0295d2c3b614b321a3b2f514dd22a
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_mesothelial_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	UPK3B GATA4 GRID2 EPS8L1 ST6GAL2 FNDC1	4.46e-05	187	152	6	8e8f1f2a78ac5f13a414fd448af7d7ff1ea86f0f
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SHROOM3 MAB21L4 TJP1 NBEAL2 MTCL1 DIAPH3	4.46e-05	187	152	6	d4b0afd9b92c47c8aa348bbd1af7eb54c3d478f2
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	WIPF3 PTGER4 BMP7 TJP1 RIPOR1 ADAMTS14	4.46e-05	187	152	6	24c2a3962da364e46e98abeab5f8234376fa26bb
ToppCell	wk_15-18-Hematologic-Myeloid-Basophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ADAM8 ABCA7 PLEKHM1 RHEX SAMD14 PLAAT5	4.60e-05	188	152	6	3638d85452de15a060146628fbbad9d2a36feb13
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 GRID2 IRS1 FNDC1 MTCL1 PALLD	4.60e-05	188	152	6	293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ALKAL1 IRS1 FNDC1 HMCN2 MTCL1 PALLD	4.60e-05	188	152	6	c29aaae3c5bb7cd6b9b3defd4d27afde3af19ba0
ToppCell	Fetal_29-31_weeks-Mesenchymal-airway_smooth_muscle_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ADAM19 ALKAL1 AXL IRS1 FNDC1 MTCL1	4.60e-05	188	152	6	4d1e5f85342ae550086609d7680e32730b78b5d2
ToppCell	AT1-AT2_cells-Donor_01\|World / lung cells shred on cell class, cell subclass, sample id	MAB21L4 UPK3B ABCA7 TJP1 FAM167A TNS1	4.60e-05	188	152	6	be710bc957118cf426dd71c2d57e6f1b41c9a467
ToppCell	PCW_07-8.5-Mesenchymal-Mesenchymal_myocytic-mes_immature_ASM2_(12)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	ADAM19 ALKAL1 IRS1 MTCL1 ADAMTS14 PALLD	4.60e-05	188	152	6	3004e961d214919e08c7cd5f10c3de5cf85b35a3
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 AXL GRID2 IRS1 FNDC1 PALLD	4.73e-05	189	152	6	7ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCell	COPD-Epithelial-ATI\|Epithelial / Disease state, Lineage and Cell class	UPK3B SLC19A1 NBEAL2 FAM167A DIAPH3 TNS1	4.73e-05	189	152	6	14e8e57e4db336fbef005270647983b4edf407c0
ToppCell	RV-15._Ventricular_Cardiomyocyte_III\|World / Chamber and Cluster_Paper	XIRP1 OBSCN KCP ZNF331 MAST4 PALLD	4.73e-05	189	152	6	0a82931b5f6c0a6427ca3edd5e2235ac49099d40
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_1-D231\|Adult / Lineage, Cell type, age group and donor	SHROOM3 TJP1 NBEAL2 DIAPH3 TMC5 PALLD	4.73e-05	189	152	6	5a04cb25f8f0447b2cecdb6c3695029281aca26d
ToppCell	Control-Stromal_mesenchymal-Lung_smooth_muscle\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ALKAL1 GRID2 FNDC1 TENM4 ADAMTSL4 PALLD	4.73e-05	189	152	6	45e588b2a4ad9e3ff74e22d9d627ed3571f3b8b8
Drug	Hydroflumethiazide [135-09-1]; Down 200; 12uM; MCF7; HT_HG-U133A	PRKD2 ARHGAP17 PTPRU ZC3H3 CDK10 EPN2 BMP7 LARP4B MAST4 SLC19A1 GPR153 SMPD1	7.36e-09	195	151	12	1687_DN
Drug	clozapine; Down 200; 10uM; MCF7; HT_HG-U133A	MIIP MAB21L4 EPS8L1 ABCA7 PIGQ EHBP1L1 MAST4 CASKIN2 VWA5A GPR153 AGFG2 TNS1	8.25e-09	197	151	12	5589_DN
Drug	SB 202190; Up 200; 1uM; PC3; HT_HG-U133A	PRKD2 CENPT CNTNAP1 EPS8L1 PTPRU ABCA7 CDK10 CASKIN2 SLC19A1 GPR153 AGFG2	9.54e-08	199	151	11	7058_UP
Drug	Beta-Escin [11072-93-8]; Down 200; 3.2uM; PC3; HT_HG-U133A	ATXN2L PTPRU EPN2 PIGQ TENM4 AGFG2 CRYBG1 KATNIP TNS1 HCFC1	7.08e-07	194	151	10	3807_DN
Drug	Cefaclor [70356-03-5]; Up 200; 10.4uM; MCF7; HT_HG-U133A	PTPRU THSD1 PIGQ BMP7 CASKIN2 GPR153 ZNF764 FGD1 FGFR4 HCFC1	7.78e-07	196	151	10	2843_UP
Drug	15d-PGJ2; Down 200; 10uM; PC3; HT_HG-U133A	HIVEP2 GTSE1 TRIOBP IRS1 SLF2 RALGPS1 CBX7 RIPOR1 JPT2	3.64e-06	182	151	9	1231_DN
Drug	geldanamycin; Down 200; 1uM; MCF7; HT_HG-U133A	MIIP PTPRU EPN2 BMP7 CASKIN2 BRPF1 RIPOR1 MTCL1 HCFC1	5.87e-06	193	151	9	1653_DN
Drug	LY 294002; Down 200; 10uM; MCF7; HT_HG-U133A	MIIP EPS8L1 EPN2 BMP7 SLC19A1 BRPF1 RIPOR1 FGFR4 HCFC1	5.87e-06	193	151	9	1664_DN
Drug	Pridinol methanesulfonate salt [6856-31-1]; Down 200; 10.2uM; MCF7; HT_HG-U133A	EPS8L1 EPN2 KIDINS220 CASKIN2 RIPOR1 KATNIP SMPD1 SNAPC4 TMC5	6.13e-06	194	151	9	7214_DN
Drug	Bupivacaine hydrochloride [18010-40-7]; Up 200; 12.4uM; MCF7; HT_HG-U133A	DBP PTPRU EPN2 EHBP1L1 MAST4 FGD1 FGFR4 SNAPC4 HCFC1	6.39e-06	195	151	9	7435_UP
Drug	Homosalate [118-56-9]; Down 200; 15.2uM; PC3; HT_HG-U133A	MIIP EPN2 BMP6 EHBP1L1 MAST4 SLC19A1 NBEAL2 SORBS3 HCFC1	6.39e-06	195	151	9	4533_DN
Drug	Diphenidol hydrochloride [3254-89-5]; Up 200; 11.6uM; MCF7; HT_HG-U133A	ADAM19 ALDH1L1 ABCA7 CDK10 BMP6 EHBP1L1 MAST4 SLC19A1 RIPOR1	6.39e-06	195	151	9	7406_UP
Drug	2-propylpentanoic acid; Down 200; 200uM; MCF7; HT_HG-U133A	MIIP EPS8L1 ZC3H3 ABCA7 CDK10 PIGQ CASKIN2 VWA5A HCFC1	6.66e-06	196	151	9	5574_DN
Drug	(-)-Cinchonidine [485-71-2]; Down 200; 13.6uM; MCF7; HT_HG-U133A	MIIP DNAJC4 ALDH1L1 DBP BMP7 VWA5A RALGPS1 SNAPC4 HCFC1	6.93e-06	197	151	9	2772_DN
Drug	Flavoxate hydrochloride [3717-88-2]; Up 200; 9.4uM; MCF7; HT_HG-U133A	HIVEP2 THSD1 EPN2 MAST4 AGFG2 CBX7 FGD1 TMC5 HCFC1	6.93e-06	197	151	9	7405_UP
Drug	Boldine [476-70-0]; Down 200; 12.2uM; MCF7; HT_HG-U133A	EPS8L1 THSD1 EPN2 MAST4 NBEAL2 ZNF764 AGFG2 RIPOR1 SNAPC4	6.93e-06	197	151	9	2804_DN
Drug	Trimeprazine tartrate [4330-99-8]; Down 200; 5.4uM; MCF7; HT_HG-U133A	MIIP CENPT MAB21L4 GTSE1 EPS8L1 CDK10 MAST4 SLC19A1 SMPD1	6.93e-06	197	151	9	3478_DN
Drug	nordihydroguaiaretic acid; Down 200; 1uM; MCF7; HT_HG-U133A	ATXN2L MAB21L4 ADAM8 ABCA7 CASKIN2 SORBS3 FGD1 SMPD1 HCFC1	7.22e-06	198	151	9	5583_DN
Drug	Medrysone [2668-66-8]; Down 200; 11.6uM; MCF7; HT_HG-U133A	MIIP NLRX1 C10orf95 ALDH1L1 THSD1 BMP7 EHBP1L1 AGFG2 FGD1	7.22e-06	198	151	9	3603_DN
Drug	Oxethazaine [126-27-2]; Down 200; 8.6uM; MCF7; HT_HG-U133A	MIIP TRIOBP ZC3H3 CASKIN2 NBEAL2 FGD1 KATNIP FGFR4 KLHDC10	7.52e-06	199	151	9	1484_DN
Drug	Piroxicam [36322-90-4]; Down 200; 12uM; MCF7; HT_HG-U133A	MIIP TBKBP1 VWA5A ZNF764 SORBS3 FGD1 SNAPC4 TMC5 HCFC1	7.52e-06	199	151	9	2252_DN
Drug	2-propylpentanoic acid; Up 200; 50uM; HL60; HT_HG-U133A	CNTNAP1 EPS8L1 CDK10 EPN2 BMP7 LARP4B GPR153 SAMD14 PALLD	7.84e-06	200	151	9	6181_UP
Drug	fullerene C60	PRKD2 ATXN2L SHROOM3 ZNF775 ADAM19 TBKBP1 NLRX1 GTSE1 MBP BUD13 CCDC187 DBP THSD1 ADAM8 EPN2 EHBP1L1 TENM4 CASKIN2 GPR153 RIPOR1 FGFR4 TMC5 TNS1 ADAMTSL4 CRTC2	1.75e-05	1498	151	25	ctd:C069837
Drug	MG-262; Down 200; 0.1uM; PC3; HT_HG-U133A	HIVEP2 GTSE1 TRIOBP IRS1 SHROOM2 TENM4 CBX7 SAC3D1	2.09e-05	173	151	8	7068_DN
Drug	Zardaverine [101975-10-4]; Up 200; 15uM; HL60; HT_HG-U133A	COL17A1 AXL BMP6 AGFG2 TMC5 SAMD14 TNS1 PALLD	2.36e-05	176	151	8	2926_UP
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	SHROOM2 CASKIN2 VWA5A NBEAL2 SORBS3 CBX7 RIPOR1 SNAPC4	3.37e-05	185	151	8	5585_DN
Drug	0179445-0000 [211246-22-9]; Down 200; 10uM; MCF7; HT_HG-U133A	DPH1 HIVEP2 MBP BMP7 SLC19A1 ZNF764 KATNIP MTCL1	3.37e-05	185	151	8	4755_DN
Drug	Sulconazole nitrate [61318-91-0]; Up 200; 8.6uM; MCF7; HT_HG-U133A	TBKBP1 NLRX1 GATA4 C10orf95 ABCA7 AGFG2 FGD1 TNS1	3.93e-05	189	151	8	4998_UP
Drug	Heptaminol hydrochloride [543-15-7]; Up 200; 22uM; MCF7; HT_HG-U133A	MIIP TBKBP1 NLRX1 MBP C10orf95 ZC3H3 BMP6 KIDINS220	4.55e-05	193	151	8	1703_UP
Drug	geldanamycin; Down 200; 1uM; PC3; HT_HG-U133A	MIIP HIVEP2 CENPT EHBP1L1 SLC19A1 SORBS3 RIPOR1 KLHDC10	4.55e-05	193	151	8	1228_DN
Drug	valinomycin; Down 200; 0.1uM; PC3; HT_HG-U133A	EPS8L1 SHROOM2 RALGPS1 MTCL1 FGFR4 SNAPC4 TNS1 HCFC1	4.90e-05	195	151	8	5911_DN
Drug	Meptazinol hydrochloride [59263-76-2]; Up 200; 14.8uM; HL60; HT_HG-U133A	ATXN2L ADAM8 EPN2 BMP7 VWA5A MTCL1 TMC5 TNS1	4.90e-05	195	151	8	2906_UP
Drug	Daunorubicin hydrochloride [23541-50-6]; Up 200; 7uM; MCF7; HT_HG-U133A	DNAJC4 ADAM19 ADAM8 ABCA7 EHBP1L1 VWA5A SORBS3 SMPD1	4.90e-05	195	151	8	4983_UP
Drug	Tranylcypromine hydrochloride [1986-47-6]; Down 200; 23.6uM; MCF7; HT_HG-U133A	ABCA7 PIGQ MAST4 CASKIN2 VWA5A RALGPS1 FGD1 FGFR4	4.90e-05	195	151	8	2264_DN
Drug	Diphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A	MIIP CENPT TRIOBP BMP7 MAST4 BRPF1 RIPOR1 HCFC1	5.08e-05	196	151	8	1708_DN
Drug	Epivincamine [6835-99-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A	HIVEP2 ALDH1L1 EHBP1L1 GPR153 RALGPS1 NBEAL2 FGD1 HCFC1	5.08e-05	196	151	8	2775_DN
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; HL60; HT_HG-U133A	MIIP CENPT ALDH1L1 ADAM8 KIDINS220 VWA5A CBX7 SMPD1	5.08e-05	196	151	8	2437_DN
Drug	Yohimbine hydrochloride [65-19-0]; Down 200; 10.2uM; MCF7; HT_HG-U133A	MIIP TRIOBP ALDH1L1 CDK10 VWA5A RALGPS1 FGFR4 SNAPC4	5.08e-05	196	151	8	2755_DN
Drug	Hymecromone [90-33-5]; Down 200; 22.8uM; MCF7; HT_HG-U133A	TBKBP1 NLRX1 THSD1 VWA5A GPR153 AGFG2 FGD1 FGFR4	5.08e-05	196	151	8	3383_DN
Drug	Cyclacillin [3485-14-1]; Down 200; 11.8uM; PC3; HT_HG-U133A	EPS8L1 THSD1 ABCA7 CDK10 BMP7 FGD1 SMPD1 TNS1	5.26e-05	197	151	8	3800_DN
Drug	Monensin sodium salt [22373-78-0]; Down 200; 5.8uM; MCF7; HT_HG-U133A	ADAM19 MAB21L4 GATA4 BMP6 EHBP1L1 RALGPS1 RIPOR1 HCFC1	5.26e-05	197	151	8	4726_DN
Drug	Pseudopelletierine hydrochloride [6164-62-1]; Up 200; 21uM; HL60; HG-U133A	HIVEP2 DBP THSD1 ADAM8 SLF2 CBX7 SMPD1 SNAPC4	5.26e-05	197	151	8	1774_UP
Drug	Ajmaline [4360-12-7]; Up 200; 12.2uM; HL60; HG-U133A	MIIP DPH1 MAB21L4 CNTNAP1 MBP ALDH1L1 SORBS3 SAMD14	5.26e-05	197	151	8	1749_UP
Drug	trifluoperazine dihydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	PRKD2 ZC3H3 SLF2 CASKIN2 ZNF764 AGFG2 KATNIP HCFC1	5.26e-05	197	151	8	6984_DN
Drug	N6,2-O-dibutyryladenosine 3,5-cyclic monophosphate sodium salt; Up 200; 2uM; MCF7; HT_HG-U133A_EA	DNAJC4 HIVEP2 PTPRU EHBP1L1 MAST4 VWA5A GPR153 CBX7	5.26e-05	197	151	8	959_UP
Drug	genistein; Down 200; 10uM; MCF7; HT_HG-U133A	ATXN2L GATA4 EPS8L1 PTPRU LARP4B GPR153 RALGPS1 TMC5	5.26e-05	197	151	8	6952_DN
Drug	Thalidomide [50-35-1]; Down 200; 15.4uM; PC3; HT_HG-U133A	AXL SHROOM2 ADAM8 NBEAL2 CBX7 KATNIP FGFR4 KLHDC10	5.26e-05	197	151	8	2095_DN
Drug	Dinoprost trometamol [38362-01-5]; Down 200; 8.4uM; MCF7; HT_HG-U133A	MAB21L4 PIGQ MAST4 GPR153 SORBS3 FGD1 SMPD1 FGFR4	5.26e-05	197	151	8	3308_DN
Drug	Noscapine [128-62-1]; Up 200; 9.6uM; HL60; HG-U133A	MIIP DPH1 EPS8L1 THSD1 ADAM8 CDK10 BMP6 VWA5A	5.46e-05	198	151	8	1753_UP
Drug	Pinacidil [85371-64-8]; Up 200; 16.4uM; MCF7; HT_HG-U133A	MAB21L4 NLRX1 ALDH1L1 PIGQ BMP7 RALGPS1 RIPOR1 TNKS	5.46e-05	198	151	8	7437_UP
Drug	Trimethadione [127-48-0]; Down 200; 28uM; MCF7; HT_HG-U133A	MIIP DNAJC4 CENPT C10orf95 MAST4 RALGPS1 ZNF764 MTCL1	5.46e-05	198	151	8	2846_DN
Drug	Oleandomycin phosphate [7060-74-4]; Up 200; 5uM; MCF7; HT_HG-U133A	DNAJC4 C10orf95 EPS8L1 ADAM8 NBEAL2 AGFG2 CBX7 HCFC1	5.46e-05	198	151	8	1518_UP
Drug	estradiol, USP; Up 200; 0.01uM; HL60; HT_HG-U133A	TRIOBP EPS8L1 CDK10 BMP7 GPR153 SORBS3 AGFG2 PALLD	5.46e-05	198	151	8	6200_UP
Drug	thioridazine hydrochloride; Down 200; 10uM; MCF7; HT_HG-U133A	ZC3H3 CDK10 BMP7 KIDINS220 SLC19A1 GPR153 NBEAL2 SMPD1	5.46e-05	198	151	8	1655_DN
Drug	Fenofibrate [49562-28-9]; Down 200; 11uM; MCF7; HT_HG-U133A	DNAJC4 CENPT TRIOBP CDK10 BMP7 NBEAL2 ZNF764 HCFC1	5.46e-05	198	151	8	7474_DN
Drug	ICI 182,780; Down 200; 0.01uM; HL60; HT_HG-U133A	TBKBP1 MAB21L4 EPN2 BMP7 VWA5A ZNF764 CBX7 HCFC1	5.46e-05	198	151	8	6197_DN
Drug	Nifurtimox [23256-30-6]; Down 200; 14uM; PC3; HT_HG-U133A	DNAJC4 DBP CDK10 BMP6 SLC19A1 SMPD1 KLHDC10 HCFC1	5.46e-05	198	151	8	6608_DN
Drug	PNU-0230031 [267429-39-0]; Down 200; 1uM; MCF7; HT_HG-U133A	MIIP ATXN2L MAB21L4 EPN2 EHBP1L1 GPR153 SORBS3 RIPOR1	5.46e-05	198	151	8	4757_DN
Drug	Ricinine [524-40-3]; Up 200; 24.4uM; MCF7; HT_HG-U133A	MIIP EPS8L1 CDK10 BMP6 EHBP1L1 RALGPS1 SORBS3 FGFR4	5.46e-05	198	151	8	6206_UP
Drug	rotenone; Down 200; 1uM; MCF7; HT_HG-U133A	THSD1 PIGQ EHBP1L1 FGD1 FGFR4 SNAPC4 TNS1 HCFC1	5.46e-05	198	151	8	5915_DN
Drug	Karakoline [39089-30-0]; Up 200; 10.6uM; HL60; HT_HG-U133A	ADAM19 HIVEP2 TRIOBP EPS8L1 EPN2 BMP7 SORBS3 FGD1	5.65e-05	199	151	8	2203_UP
Drug	Hesperetin [520-33-2]; Up 200; 13.2uM; MCF7; HT_HG-U133A	DNAJC4 COL17A1 GATA4 EPS8L1 ADAM8 ABCA7 PIGQ HCFC1	5.65e-05	199	151	8	1531_UP
Drug	Atracurium besylate [64228-81-5]; Up 200; 3.2uM; MCF7; HT_HG-U133A	DNAJC4 ALDH1L1 ABCA7 PIGQ EHBP1L1 MAST4 GPR153 RIPOR1	5.65e-05	199	151	8	7477_UP
Drug	Atracurium besylate [64228-81-5]; Down 200; 3.2uM; MCF7; HT_HG-U133A	TRIOBP PTPRU SHROOM2 LARP4B CASKIN2 BRPF1 RIPOR1 SMPD1	5.65e-05	199	151	8	1702_DN
Drug	Amrinone [60719-84-8]; Down 200; 21.4uM; MCF7; HT_HG-U133A	ATXN2L CENPT MAB21L4 THSD1 SLF2 CASKIN2 MTCL1 HCFC1	5.86e-05	200	151	8	3465_DN
Drug	prochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A	GATA4 EPS8L1 CDK10 MAST4 SLC19A1 SORBS3 FGFR4 TMC5	5.86e-05	200	151	8	5212_DN
Drug	irinotecan HCl; Down 200; 100uM; PC3; HT_HG-U133A	HIVEP2 MBP EPN2 LARP4B TENM4 MAST4 MTCL1	1.48e-04	171	151	7	7535_DN
Drug	Trichostatin A, from Streptomyces sp.; Up 200; 0.1uM; HL60; HT_HG-U133A	EPN2 BMP6 KIDINS220 SORBS3 CBX7 RIPOR1 PALLD	2.41e-04	185	151	7	2949_UP
Drug	natrin	RYR1 KCNA3	2.60e-04	4	151	2	CID000019130
Drug	Bastadin 10	ENPP3 RYR1	2.60e-04	4	151	2	CID009589366
Drug	LY 294002; Down 200; 10uM; HL60; HT_HG-U133A	ATXN2L KCNA3 MDN1 SLC19A1 NBEAL2 SNAPC4 TNS1	2.66e-04	188	151	7	6186_DN
Drug	Colchicine [64-86-8]; Up 200; 10uM; MCF7; HT_HG-U133A	ATXN2L MBP EPN2 FGD1 SNAPC4 ADAMTSL4 PALLD	2.74e-04	189	151	7	5675_UP
Drug	phosphopantotheine	ENPP3 GRID2 ALDH1L1 PTPRU TNS1	3.02e-04	88	151	5	CID000000987
Drug	rosiglitazone; Down 200; 10uM; PC3; HT_HG-U133A	MIIP NLRX1 SHROOM2 BMP6 SORBS3 TNKS SNAPC4	3.11e-04	193	151	7	1233_DN
Drug	Butylparaben [94-26-8]; Down 200; 20.6uM; MCF7; HT_HG-U133A	MIIP MAB21L4 EPS8L1 EHBP1L1 KIDINS220 KATNIP SNAPC4	3.11e-04	193	151	7	5608_DN
Drug	Progesterone [57-83-0]; Down 200; 12.8uM; PC3; HT_HG-U133A	CENPT ADAM8 EPN2 EHBP1L1 KIDINS220 CASKIN2 VWA5A	3.11e-04	193	151	7	6646_DN
Drug	17-AAG; Down 200; 1uM; MCF7; HT_HG-U133A	EPN2 EHBP1L1 SLC19A1 CBX7 RIPOR1 MTCL1 SNAPC4	3.11e-04	193	151	7	5215_DN
Drug	(-) -Levobunolol hydrochloride [27912-14-7]; Down 200; 12.2uM; MCF7; HT_HG-U133A	ADAM19 NLRX1 CNTNAP1 C10orf95 THSD1 KIDINS220 PALLD	3.21e-04	194	151	7	4134_DN
Drug	retinoic acid; Down 200; 1uM; PC3; HT_HG-U133A	MIIP THSD1 EHBP1L1 NBEAL2 RIPOR1 SNAPC4 HCFC1	3.21e-04	194	151	7	1211_DN
Drug	nordihydroguaiaretic acid; Down 200; 1uM; PC3; HT_HG-U133A	CENPT DBP EPN2 MAST4 SORBS3 RIPOR1 SNAPC4	3.21e-04	194	151	7	1223_DN
Drug	Dirithromycin [62013-04-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A	MAB21L4 NLRX1 ZC3H3 ABCA7 MAST4 CASKIN2 SORBS3	3.21e-04	194	151	7	2863_DN
Drug	Minocycline hydrochloride [13614-98-7]; Down 200; 8uM; HL60; HT_HG-U133A	EPS8L1 ALDH1L1 LARP4B KCNA3 NBEAL2 SORBS3 HCFC1	3.21e-04	194	151	7	2405_DN
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	EPS8L1 SHROOM2 BMP7 SLC19A1 GPR153 RIPOR1 SNAPC4	3.21e-04	194	151	7	6933_DN
Drug	Indapamide [26807-65-8]; Down 200; 10.6uM; MCF7; HT_HG-U133A	MIIP HIVEP2 EPS8L1 ALDH1L1 ZC3H3 SORBS3 SNAPC4	3.21e-04	194	151	7	3859_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Down 200; 15.6uM; PC3; HT_HG-U133A	AXL DBP ABCA7 CDK10 CASKIN2 NBEAL2 SORBS3	3.21e-04	194	151	7	4284_DN
Drug	Fillalbin [4540-25-4]; Up 200; 13.8uM; PC3; HT_HG-U133A	EPS8L1 PIGQ BMP7 EHBP1L1 VWA5A RALGPS1 TNS1	3.21e-04	194	151	7	4092_UP
Drug	(+)-Isoproterenol (+)-bitartrate salt [14638-70-1]; Down 200; 11uM; MCF7; HT_HG-U133A	ATXN2L DNAJC4 TBKBP1 NLRX1 CNTNAP1 VWA5A SMPD1	3.21e-04	194	151	7	3384_DN
Drug	Idoxuridine [54-42-2]; Down 200; 11.2uM; MCF7; HT_HG-U133A	TRIOBP PTPRU ZC3H3 CDK10 CASKIN2 SORBS3 CBX7	3.21e-04	194	151	7	1480_DN
Drug	Gabexate mesilate [56974-61-9]; Down 200; 9.6uM; MCF7; HT_HG-U133A	EPS8L1 PTPRU ADAM8 EHBP1L1 NBEAL2 BRPF1 RIPOR1	3.21e-04	194	151	7	4804_DN
Drug	chloroform	PRKD2 MBP EPS8L1 SMPD1 DTX2 JPT2	3.22e-04	138	151	6	CID000006212
Drug	Methocarbamol [532-03-6]; Down 200; 16.6uM; MCF7; HT_HG-U133A	DNAJC4 NLRX1 CDK10 EPN2 LARP4B SLF2 MTCL1	3.31e-04	195	151	7	7467_DN
Drug	Triprolidine hydrochloride [550-70-9]; Down 200; 12.8uM; MCF7; HT_HG-U133A	ATXN2L TRIOBP CDK10 LARP4B SLF2 SORBS3 SNAPC4	3.31e-04	195	151	7	7408_DN
Drug	Tetrandrine [518-34-3]; Down 200; 6.4uM; MCF7; HT_HG-U133A	DNAJC4 MAB21L4 THSD1 KATNIP SMPD1 FGFR4 SNAPC4	3.31e-04	195	151	7	6082_DN
Drug	5213008; Down 200; 18uM; MCF7; HT_HG-U133A_EA	NLRX1 GATA4 EPS8L1 EPN2 EHBP1L1 GPR153 RIPOR1	3.31e-04	195	151	7	898_DN
Drug	Asiaticoside [16830-15-2]; Down 200; 4.2uM; MCF7; HT_HG-U133A	MIIP C10orf95 DBP MAST4 NBEAL2 RIPOR1 TMC5	3.31e-04	195	151	7	3504_DN
Drug	Atropine sulfate monohydrate [5908-99-6]; Down 200; 5.8uM; MCF7; HT_HG-U133A	MIIP MBP THSD1 BMP7 SORBS3 CBX7 FGD1	3.31e-04	195	151	7	2761_DN
Drug	radicicol, diheterospora chlamydosporia; Down 200; 0.1uM; MCF7; HT_HG-U133A	PTPRU ABCA7 MAST4 VWA5A GPR153 FGFR4 HCFC1	3.31e-04	195	151	7	5579_DN
Drug	Spaglumic acid [4910-46-7]; Down 200; 13.2uM; HL60; HT_HG-U133A	TRIOBP EPS8L1 ADAM8 SLC19A1 NBEAL2 RIPOR1 PALLD	3.31e-04	195	151	7	2962_DN
Drug	Pirenperone [ 75444-65-4]; Down 200; 10.2uM; MCF7; HT_HG-U133A	NLRX1 C10orf95 EPS8L1 ALDH1L1 PIGQ FGD1 TNS1	3.42e-04	196	151	7	5639_DN
Drug	Cyanocobalamin [68-19-9]; Up 200; 3uM; MCF7; HT_HG-U133A	MAB21L4 CDK10 NBEAL2 RIPOR1 FGFR4 SNAPC4 HCFC1	3.42e-04	196	151	7	3252_UP
Disease	cortical surface area measurement	PRKD2 ATXN2L TICRR CPAMD8 SHROOM3 ADAMTSL1 ENPP3 SKIDA1 PRSS55 TRIOBP MIR1915HG PLEKHM1 PIGQ BMP6 BMP7 MAST4 ADAMTS7 TJP1 RALGPS1 TNKS MTCL1 DIAPH3 TNS1	1.79e-07	1345	145	23	EFO_0010736
Disease	smoking status measurement, systolic blood pressure	ADAMTSL1 GATA4 BMP7 TENM4 FAM167A TNKS	1.26e-04	156	145	6	EFO_0006335, EFO_0006527
Disease	vital capacity	ATXN2L SHROOM3 ADAMTSL1 HIVEP2 AOC1 MAB21L4 C16orf96 CDK10 PLEKHM1 BMP6 CCAR2 RIPOR1 MTCL1 FGFR4 DIAPH3 SNAPC4 TNS1	1.26e-04	1236	145	17	EFO_0004312
Disease	blood N(1)-acetylspermidine measurement, blood N(8)-acetylspermidine measurement	AOC1 HDAC10	1.43e-04	4	145	2	EFO_0022204, EFO_0022205
Disease	corneal endothelial cell measurement	GATA4 CITED4 RALGPS1 FAM167A TNKS	1.99e-04	108	145	5	EFO_0010079
Disease	(N(1) + N(8))-acetylspermidine measurement	AOC1 HDAC10	3.55e-04	6	145	2	EFO_0800091
Disease	congenital heart disease (implicated_via_orthology)	KMT2C USP42 SAP130 HCFC1	3.77e-04	69	145	4	DOID:1682 (implicated_via_orthology)
Disease	serine:glycine ratio	ALDH1L1 PTPRU	4.96e-04	7	145	2	EFO_0021777
Disease	Moderate albuminuria	SHROOM3 WIPF3 BMP7 EHBP1L1	6.62e-04	80	145	4	HP_0012594
Disease	Colorectal Carcinoma	CPAMD8 ADAM19 LAMA1 OBSCN GATA4 GRID2 ALDH1L1 PTPRU KMT2C BMP6 SLC19A1	7.26e-04	702	145	11	C0009402
Disease	coronary artery disease	PRKD2 SHROOM3 ADAM19 HIVEP2 BUD13 PTPRU FNDC1 EHBP1L1 LRFN2 MAST4 ADAMTS7 TNKS TNS1 SAP130 PALLD	8.19e-04	1194	145	15	EFO_0001645
Disease	Marfan syndrome (implicated_via_orthology)	BMP6 BMP7	1.05e-03	10	145	2	DOID:14323 (implicated_via_orthology)
Disease	cortical thickness	CPAMD8 SHROOM3 LAMA1 TRIOBP PLEKHM1 BMP6 BMP7 MAST4 ADAMTS7 SLC19A1 RALGPS1 MTCL1 DIAPH3 TNS1	1.21e-03	1113	145	14	EFO_0004840
Disease	Ankylosing spondylitis	TBKBP1 PTGER4	1.28e-03	11	145	2	C0038013
Disease	response to bronchodilator, FEV/FEC ratio	PRSS55 BUD13 GRID2 BMP7 LRFN2 TENM4 FAM193A MAST4 ADAMTS7 RALGPS1 NBEAL2	1.46e-03	766	145	11	EFO_0004713, GO_0097366
Disease	N-acetylputrescine measurement	AOC1 HDAC10	1.53e-03	12	145	2	EFO_0800127
Disease	N-acetyl-isoputreanine measurement	AOC1 ADAM8	1.81e-03	13	145	2	EFO_0800107
Disease	gallstones	SHROOM3 SKIDA1 GATA4 MIR1915HG	2.02e-03	108	145	4	EFO_0004210
Disease	corneal topography	WIPF3 BMP7 ADAMTS7 TJP1	2.09e-03	109	145	4	EFO_0004345
Disease	triacylglycerol 48:4 measurement	MBP TENM4	2.10e-03	14	145	2	EFO_0010407
Disease	delta-6 desaturase measurement	MAST4 DIAPH3	2.41e-03	15	145	2	EFO_0007765
Disease	body fat percentage	ATXN2L AOC1 IRS1 JAKMIP3 ZC3H3 LRFN2 RALGPS1 TNKS	2.93e-03	488	145	8	EFO_0007800
Disease	theta wave measurement	MBP TMC5	3.11e-03	17	145	2	EFO_0006873
Disease	pancreatic ductal carcinoma (is_marker_for)	ADAM8 CBX7 PALLD	3.40e-03	61	145	3	DOID:3587 (is_marker_for)
Disease	end stage renal disease (implicated_via_orthology)	IRS1 PTGER4	4.30e-03	20	145	2	DOID:783 (implicated_via_orthology)
Disease	alkaline phosphatase measurement	PRKD2 ADAMTSL1 AOC1 ENPP3 PRSS55 GATA4 KCP PLEKHM1 SLF2 CASKIN1 FAM167A TNKS	4.44e-03	1015	145	12	EFO_0004533
Disease	electrocardiography	ATXN2L AXL OBSCN ZNFX1 KCNA3 MAST4 HMCN2 PALLD	4.80e-03	530	145	8	EFO_0004327

Protein segments in the cluster

Peptide	Gene	Start	Entry
SHLNRFPARGPHGRL	CCAR2	176	Q8N163
RRAHSPASTLPNSPG	COL17A1	81	Q9UMD9
SHRHPGCAQRPRTPT	ESYT2	11	A0FGR8
RHDTPDPSPLRGARH	BUD13	156	Q9BRD0
HTGAALRFPPIRANH	CNTNAP1	791	P78357
PESPHERLGHFSQRP	CCDC187	476	A0A096LP49
PAPLRHHPRAQASGT	ADAMTSL4	246	Q6UY14
LHPLPGSRDRAHPAA	CCSMST1	26	Q4G0I0
PLPAHLSRAARNSPG	ADAM19	806	Q9H013
AHPLSPQGHPARLHR	SMPD1	61	P17405
LALALSPHGAHGRPR	ALKAL1	16	Q6UXT8
RGQALHGRHPRPPAT	FGFR4	391	P22455
HGRHPRPPATVQKLS	FGFR4	396	P22455
LNLSALHSPAHRPPG	DEPDC7	11	Q96QD5
LHSPAHRPPGFSVAQ	DEPDC7	16	Q96QD5
HPGQPARHPASSVAL	ADAM8	731	P78325
HVSGPRLVQPHGPRF	AOC1	296	P19801
RTHPSPFLALPGSHR	C1orf147	31	Q96MC9
PRLHHPAQGSAAGTP	DIAPH3	6	Q9NSV4
VNHGQDRRPHAPGRP	DPH1	396	Q9BZG8
HRPRPHLQGKHNSAP	BMP7	66	P18075
DAPHEARPPLERGHS	CACNA1B	1946	Q00975
RHSAPAAPRNSPTGL	FAM193A	656	P78312
SHLRVARSPLHPGGT	ADAMTS14	81	Q8WXS8
PSHGAPSRGHQRVAR	ADAMTS7	1671	Q9UKP4
LSSLPPRGPHHLDNS	ATXN2L	376	Q8WWM7
RAHLPPGPARHAHSI	ABCA7	1496	Q8IZY2
RPHVHRPPSLSSNGQ	QRICH2	1631	Q9H0J4
TPPVPRHRKSHSLGN	RALGPS1	331	Q5JS13
RRQAAHGPPGLHSDS	MTCL1	1866	Q9Y4B5
SGPVPRPRHGHRAVA	HCFC1	26	P51610
HATHLGRSPPPRIGS	MAB21L4	376	Q08AI8
RHGHSIKRASVPPVP	CASKIN1	746	Q8WXD9
HHRVPSPRATRSPGS	MIR1915HG	71	Q5T4H9
SGPAPHGEPARRASH	KIDINS220	1296	Q9ULH0
SRGSCVPHPSRHPLL	MDN1	2026	Q9NU22
RPPPVGHSFSRRNSA	KMT2C	1906	Q8NEZ4
PGRRRHPHSSFPQAS	PSMG3-AS1	146	Q96PY0
PRAQGLPPRRSHQHG	HIPK4	586	Q8NE63
RRHLFPQHSAPGRGV	DTX2	96	Q86UW9
RHPFLPHLGLASRPN	EPN2	226	O95208
PPGSRHSIRADGSLH	HMCN2	926	Q8NDA2
ALVGHPRHDRPPSSG	KATNIP	221	O60303
DSHEPRLGPRPRSHN	JPT2	161	Q9H910
SHLRHAIPSAERGPG	LARP4B	416	Q92615
RPGRPSTKHSPHIAA	ADAMTSL1	851	Q8N6G6
FLRHSRPHLGQPSPL	LTK	601	P29376
NVPEHRTGPFRHRAP	GRID2	956	O43424
HRPPPARSGHRCVAD	KLHDC10	86	Q6PID8
AGNHSPPISARTPHV	LRRC36	511	Q1X8D7
VASRGHPAASPALPR	PTGER4	236	P35408
RPSAHSHAGSLRPGL	GPR153	551	Q6NV75
PPPRAHGSFSHVRDA	EHBP1L1	1266	Q8N3D4
PAAPHAELLRLGSHP	KISS1R	356	Q969F8
ARHRAHPPQRPASSG	KCNA3	16	P22001
HPPQRPASSGGAHTL	KCNA3	21	P22001
ADRHPGSPRRELPHA	JAKMIP3	256	Q5VZ66
APSAPGHAPHRQASL	PRKD2	516	Q9BZL6
RHHGSSVDSAPPPGR	NLRX1	51	Q86UT6
GSARLHPPLNHSRSI	IRS1	361	P35568
GRLPGHRHSAFVPTR	IRS1	566	P35568
HAALHNPRPGPLLGA	FOXD4	221	Q12950
RGPGSRAHTPQSPHK	IQSEC3	126	Q9UPP2
GLHPPSLADNLSHRP	CASKIN2	451	Q8WXE0
AQARLTRAPGPPHSA	GTSE1	176	Q9NYZ3
IHPGTRAPADLPHGS	PTPRU	56	Q92729
RHLPSVCGGRFHPQP	NPIPB11	791	E5RHQ5
HSPLLHPRGFLRPSA	OBSCN	6816	Q5VST9
SPEHGALAPGSRRHP	OBSCN	6881	Q5VST9
SPSRSLFHFPGRHLP	OBSCN	7391	Q5VST9
NQRGRSPRSPSGHPH	PALLD	1096	Q8WX93
SLPGRANPAARHPNL	GATA4	191	P43694
LARPLGHSPADPAHV	EEF1DP3	101	Q658K8
GSRSLRGVHVPPPLH	FOXO3B	51	A0A2Z4LIS9
RSLPPPVHRHSVSGF	CEFIP	1236	Q711Q0
LALVRPPGHHGQRAA	HDAC10	126	Q969S8
KSRRGPHVPVGHNAP	C1orf43	41	Q9BWL3
PQQAPGSTRLSRAPH	C16orf96	1111	A6NNT2
PTFPHHRNKRAAPAT	CDK10	336	Q15131
GLPARPSHVRHQTEP	LINC00315	91	P59091
GPAPRIRAHNIPHDF	ENPP3	401	O14638
YPASTPGASPHHRRV	CRTC2	416	Q53ET0
LRPPSRHGHSVVAPG	FNDC1	566	Q4ZHG4
APQRHSGRVVGAHRP	CPAMD8	1841	Q8IZJ3
RRHHQFLEPAPAPGA	CENPT	411	Q96BT3
SALSPHPGLRGHEPA	FAM25E	31	A8MYX2
ASSSQRRQPPPGAAH	BMP6	166	P22004
FPPRGPNLESHSHRR	CBX7	156	O95931
LHPDRDPGNPSLHSR	DNAJC4	61	Q9NNZ3
SHLRPHEQRSPPGSS	MARCHF4	386	Q9P2E8
HPADPGSRPHLIRLF	MBP	81	P02686
ARPPPRDNSSLHSAG	MAST4	2051	O15021
SPPRSHHDAAPVDGR	KLHDC9	76	Q8NEP7
LRPDALGPTTAHHGP	KNDC1	811	Q76NI1
SPRSSPGHAPARAAL	DBP	161	Q10586
PEHKRGPLPNHFNGR	CRYBG1	176	Q9Y4K1
PGPRLHHSQSPARSL	EPS8L1	536	Q8TE68
AAPHPRPASRAFPQH	SAC3D1	16	A6NKF1
LFPPGRSTENGHPRH	RYR1	1746	P21817
HHRALFPLDRAPGAP	DIPK1C	231	Q0P6D2
LRRSLGPRAPHPGAH	OBSCN-AS1	111	Q96MR7
DAGSGRQPALRPHVH	ISL2	171	Q96A47
HPPSARSASQGARPL	FAM167A	91	Q96KS9
PGSRPGLHRHFSQEP	PLEKHM1	471	Q9Y4G2
KAASLQVPRPSPGHH	RHEX	46	Q6ZWK4
GQPHNAAGPSPHTLR	ARHGAP17	616	Q68EM7
PAGCPRPGAAHARHQ	KCP	666	Q6ZWJ8
GNSANPRERHPISHA	LAMA1	71	P25391
GAVHVLHASRAPPRG	NBEAL2	256	Q6ZNJ1
ARLAPPHGHSQPSAL	PIGQ	566	Q9BRB3
VLPCGPSPQHHRALR	FGD1	76	P98174
QHQESLGRPRPHSAP	MIIP	101	Q5JXC2
QRPGAAAARPAAHLP	SKIDA1	156	Q1XH10
RDDLGHHAPSPSPAR	SHROOM1	821	Q2M3G4
DVRFPQSPHSGRHPP	SHROOM2	416	Q13796
PAPSHPHTSSLGRRG	SHROOM3	746	Q8TF72
ARQALPRAHPAGSFH	ST6GAL2	76	Q96JF0
HPTARAFQVPRRPGH	SHISA8	341	B8ZZ34
GSPLHRLRSPLHSGP	SAMD14	76	Q8IZD0
SEAHGAARTAPPRPN	WIPF3	156	A6NGB9
SPPRCHLRPGSTAHA	SLF2	21	Q8IX21
GHRDAPRASSPPRHT	TRIOBP	1066	Q9H2D6
RHGPSSRGSLTPHPA	BRPF1	836	P55201
HPSLLPRHRGASAIN	ALDH1L1	106	O75891
HARTSQARSTQPPPH	AGFG2	201	O95081
RPPSAAAAHGPHALR	CITED4	16	Q96RK1
HGNTTASTAPPRHPR	C10orf95	101	Q9H7T3
RHRPSSPRAGAPHAL	USP42	1111	Q9H9J4
PPADHAVRPLHGARG	ZC3H3	86	Q8IXZ2
ASLARHLLTHGGPRP	ZSCAN10	536	Q96SZ4
DRAHLPGPAPRATHT	TICRR	86	Q7Z2Z1
LLAARPPGHPGAAHS	ZBTB45	156	Q96K62
PPGHPGAAHSRKQRQ	ZBTB45	161	Q96K62
PLARGDSPENRTHHP	SEC16A	336	O15027
HPGCTQTQAPRHRPL	STPG3	296	Q8N7X2
PHRARRGPSPSHKSV	THSD1	756	Q9NS62
APPGHHSVIGRPSVN	TNKS	1271	O95271
GHHPRQPPAQGLRSA	SLC19A1	461	P41440
PPLHIGASHLPRGAA	SAP130	221	Q9H0E3
RAGPAHAGHTAPMRP	TNS1	566	Q9HBL0
PATREGTPPRTHQRH	ZNF331	111	Q9NQX6
RHLRNHTGERPHPCP	ZNF775	326	Q96BV0
ATAPGHGPQRSLHVP	AXL	181	P30530
HPGGLQNHARLRTPP	TENM4	166	Q6N022
ALHSDRPPSASQPRG	VWA5A	631	O00534
HLGAQQRPAHRPGPA	SORBS3	176	O60504
VARPALPHPSVSHGN	USF3	1946	Q68DE3
ILGRARGAHRPQPPH	PRSS55	31	Q6UWB4
GASHPGRHPRANNHP	ZNFX1	46	Q9P2E3
DTHGRLRPEAQPHPS	TJP1	1166	Q07157
QPHQAPASPLGRSHS	ZNF843	76	Q8N446
PARAHGPVPRSAQAS	SNAPC4	631	Q5SXM2
DHPGPRANLNHPGSR	TMC5	171	Q6UXY8
GSRSLRGVHVPPPLH	ZNF286B	51	P0CG31
DQPPALRRSAVPHSG	PLAAT5	36	Q96KN8
GPSPPSHRLHSNRQT	PRR30	161	Q53SZ7
HVSIRHFSRPEPGQP	HIVEP2	2366	P31629
SPQLSGTARHSPAPR	RIPOR1	391	Q6ZS17
GQRHSPLSQRHSPAP	TBKBP1	331	A7MCY6
HDPPHPTQRGRHTAG	UPK3B	276	Q9BT76
PRNPGSHLGLHASPL	XIRP1	1796	Q702N8
QHRRVHSGETPFPCP	ZNF764	276	Q96H86
HHSDREPLLGPPAAR	LRFN2	691	Q9ULH4