Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlamin binding

TMEM201 SYNE1 DMD

4.91e-0519763GO:0005521
GeneOntologyMolecularFunctioncytoskeleton-nuclear membrane anchor activity

SYNE3 SYNE1

1.42e-045762GO:0140444
GeneOntologyBiologicalProcessnucleus localization

TMEM201 SYNE3 SYNE1 DMD

2.07e-0544764GO:0051647
GeneOntologyCellularComponentTORC2 complex

SESN3 RICTOR

4.62e-049762GO:0031932
GeneOntologyCellularComponentmicrotubule organizing center attachment site

SYNE3 SYNE1

7.02e-0411762GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

SYNE3 SYNE1

7.02e-0411762GO:0034993
GeneOntologyCellularComponentnuclear membrane protein complex

SYNE3 SYNE1

7.02e-0411762GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

SYNE3 SYNE1

7.02e-0411762GO:0106094
GeneOntologyCellularComponentTOR complex

SESN3 RICTOR

8.41e-0412762GO:0038201
GeneOntologyCellularComponentcentriolar satellite

FLII CNTRL UPF3B PIBF1

1.22e-03128764GO:0034451
GeneOntologyCellularComponentdendritic spine head

SYNE1 SRGAP2

1.51e-0316762GO:0044327
GeneOntologyCellularComponentcytosolic region

TRIM9 ARL6IP5 KIF5C

2.12e-0370763GO:0099522
GeneOntologyCellularComponentdystrophin-associated glycoprotein complex

DMD UTRN

2.38e-0320762GO:0016010
GeneOntologyCellularComponentfilopodium membrane

DMD UTRN

2.62e-0321762GO:0031527
GeneOntologyCellularComponentribosome

MTG1 RPS15 MRPL58 MRPL33 DMD

2.89e-03267765GO:0005840
GeneOntologyCellularComponentRNA polymerase II transcription regulator complex

NCOA3 ING2 CREBBP STAT1 STAT4

3.13e-03272765GO:0090575
GeneOntologyCellularComponentpostsynaptic membrane

SLITRK2 SYNE1 SRGAP2 GRIN2A DMD UTRN

3.56e-03405766GO:0045211
GeneOntologyCellularComponentpostsynapse

KIF21B FILIP1 SLITRK2 SYNE1 SRGAP2 GRIN2A KIF5C DMD PRAF2 UTRN

3.70e-0310187610GO:0098794
GeneOntologyCellularComponentglycoprotein complex

DMD UTRN

3.71e-0325762GO:0090665
GeneOntologyCellularComponentdendrite

KIF21B SLITRK2 TRIM9 SYNE1 SRGAP2 TRPM1 GRIN2A KIF5C STAT1

3.85e-03858769GO:0030425
GeneOntologyCellularComponentnuclear protein-containing complex

ORC1 NCOA3 SYNE3 ING2 SYNE1 NELFB NUP214 UPF3B CREBBP DDX39B STAT1 STAT4

3.90e-0313777612GO:0140513
GeneOntologyCellularComponentdendritic tree

KIF21B SLITRK2 TRIM9 SYNE1 SRGAP2 TRPM1 GRIN2A KIF5C STAT1

3.91e-03860769GO:0097447
DomainSpectrin

SYNE3 SYNE1 DMD UTRN

1.90e-0623744PF00435
DomainSpectrin_repeat

SYNE3 SYNE1 DMD UTRN

5.00e-0629744IPR002017
DomainSpectrin/alpha-actinin

SYNE3 SYNE1 DMD UTRN

7.51e-0632744IPR018159
DomainSPEC

SYNE3 SYNE1 DMD UTRN

7.51e-0632744SM00150
DomainDystrophin

DMD UTRN

1.55e-052742IPR016344
DomainPRA1

ARL6IP5 PRAF2

4.63e-053742PF03208
DomainPrenylated_rab_accept_PRA1

ARL6IP5 PRAF2

4.63e-053742IPR004895
DomainZZ

DMD UTRN CREBBP

4.67e-0518743PF00569
DomainZF_ZZ_2

DMD UTRN CREBBP

4.67e-0518743PS50135
DomainZF_ZZ_1

DMD UTRN CREBBP

4.67e-0518743PS01357
DomainZnf_ZZ

DMD UTRN CREBBP

5.53e-0519743IPR000433
DomainZnF_ZZ

DMD UTRN CREBBP

5.53e-0519743SM00291
DomainLeu-rich_rpt_typical-subtyp

FLII SLITRK2 LRRN1 PXDNL ECM2 CNTRL

7.23e-05177746IPR003591
DomainLRR_TYP

FLII SLITRK2 LRRN1 PXDNL ECM2 CNTRL

7.23e-05177746SM00369
DomainKASH

SYNE3 SYNE1

9.24e-054742PF10541
DomainKASH

SYNE3 SYNE1

9.24e-054742IPR012315
DomainKASH

SYNE3 SYNE1

9.24e-054742PS51049
DomainKASH

SYNE3 SYNE1

9.24e-054742SM01249
DomainActinin_actin-bd_CS

SYNE1 DMD UTRN

9.99e-0523743IPR001589
DomainACTININ_2

SYNE1 DMD UTRN

9.99e-0523743PS00020
DomainACTININ_1

SYNE1 DMD UTRN

9.99e-0523743PS00019
DomainLRR

FLII SLITRK2 LRRN1 PXDNL ECM2 CNTRL

1.45e-04201746PS51450
DomainNuc_rcpt_coact

NCOA3 CREBBP

2.30e-046742IPR009110
DomainEF-hand_dom_typ1

DMD UTRN

2.30e-046742IPR015153
DomainEF-hand_dom_typ2

DMD UTRN

2.30e-046742IPR015154
DomainEF-hand_2

DMD UTRN

2.30e-046742PF09068
DomainEF-hand_3

DMD UTRN

2.30e-046742PF09069
DomainLRR_1

FLII SLITRK2 LRRN1 PXDNL ECM2 CNTRL

2.31e-04219746PF00560
DomainSTAT_TF_prot_interaction

STAT1 STAT4

3.21e-047742IPR013799
DomainSTAT_TF_DNA-bd_sub

STAT1 STAT4

3.21e-047742IPR012345
DomainSTAT

STAT1 STAT4

3.21e-047742IPR001217
DomainSTAT_TF_coiled-coil

STAT1 STAT4

3.21e-047742IPR015988
Domain-

STAT1 STAT4

3.21e-0477422.60.40.630
DomainSTAT_int

STAT1 STAT4

3.21e-047742SM00964
DomainSTAT_TF_DNA-bd

STAT1 STAT4

3.21e-047742IPR013801
DomainSTAT_bind

STAT1 STAT4

3.21e-047742PF02864
DomainSTAT_int

STAT1 STAT4

3.21e-047742PF02865
Domain-

STAT1 STAT4

3.21e-0477421.10.532.10
DomainSTAT_alpha

STAT1 STAT4

3.21e-047742PF01017
Domain-

STAT1 STAT4

3.21e-0477421.20.1050.20
DomainSTAT_TF_alpha

STAT1 STAT4

4.27e-048742IPR013800
DomainLRR_8

FLII SLITRK2 LRRN1 PXDNL ECM2

5.87e-04171745PF13855
DomainLeu-rich_rpt

FLII SLITRK2 LRRN1 PXDNL ECM2 CNTRL

7.16e-04271746IPR001611
Domain-

FLII SLITRK2 LRRN1 PXDNL ECM2 CNTRL

1.71e-033217463.80.10.10
DomainL_dom-like

FLII SLITRK2 LRRN1 PXDNL ECM2 CNTRL

1.91e-03328746IPR032675
DomainCH

SYNE1 DMD UTRN

2.19e-0365743SM00033
DomainCH

SYNE1 DMD UTRN

2.70e-0370743PF00307
Domain-

SYNE1 DMD UTRN

2.81e-03717431.10.418.10
DomainCH

SYNE1 DMD UTRN

3.04e-0373743PS50021
DomainCH-domain

SYNE1 DMD UTRN

3.29e-0375743IPR001715
DomainFCH

SRGAP1 SRGAP2

3.40e-0322742PF00611
DomainFCH

SRGAP1 SRGAP2

3.40e-0322742SM00055
DomainFCH_dom

SRGAP1 SRGAP2

3.71e-0323742IPR001060
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

NCOA3 MITF FAM91A1 KATNIP RICTOR UPF3B PLEKHA6 NOL9 DMD CCDC6 ESPL1 STAT1

2.89e-061038771226673895
Pubmed

Fanconi anemia core complex gene promoters harbor conserved transcription regulatory elements.

STAT1 STAT4

4.84e-06277221826217
Pubmed

Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy.

DMD UTRN

4.84e-06277210525423
Pubmed

Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils.

DMD UTRN

4.84e-06277220434517
Pubmed

Plasma lipidomic analysis shows a disease progression signature in mdx mice.

DMD UTRN

4.84e-06277234155298
Pubmed

In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.

DMD UTRN

4.84e-06277228790199
Pubmed

Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.

DMD UTRN

4.84e-06277224466085
Pubmed

The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy.

DMD UTRN

4.84e-06277227110493
Pubmed

Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.

DMD UTRN

4.84e-06277224781208
Pubmed

Isolation and characterization of a genomic clone from the murine utrophin locus.

DMD UTRN

4.84e-0627728268660
Pubmed

Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.

DMD UTRN

4.84e-06277225859846
Pubmed

Tyrosine phosphorylation regulates the partitioning of STAT1 between different dimer conformations.

STAT1 STAT4

4.84e-06277218591661
Pubmed

G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.

DMD UTRN

4.84e-0627727731967
Pubmed

Quantifying Protection in Disordered Proteins Using Millisecond Hydrogen Exchange-Mass Spectrometry and Peptic Reference Peptides.

NCOA3 CREBBP

4.84e-06277228675294
Pubmed

Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.

DMD UTRN

4.84e-06277227037492
Pubmed

Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.

DMD UTRN

4.84e-06277216710609
Pubmed

The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway.

STAT1 STAT4

4.84e-06277210097133
Pubmed

Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.

DMD UTRN

4.84e-06277216487708
Pubmed

High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups.

STAT1 STAT4

4.84e-06277219333953
Pubmed

Polymorphisms of signal transducers and activators of transcription 1 and 4 (STAT1 and STAT4) contribute to progression of childhood IgA nephropathy.

STAT1 STAT4

4.84e-06277220045654
Pubmed

Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.

DMD UTRN

4.84e-06277230672725
Pubmed

Acetyltransferases CBP/p300 Control Transcriptional Switch of β-Catenin and Stat1 Promoting Osteoblast Differentiation.

CREBBP STAT1

4.84e-06277237850815
Pubmed

Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.

DMD UTRN

4.84e-06277221677768
Pubmed

Identification of SRGAP2 as a potential oncogene and a prognostic biomarker in hepatocellular carcinoma.

SRGAP1 SRGAP2

4.84e-06277233984363
Pubmed

Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.

DMD UTRN

4.84e-0627727962191
Pubmed

Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse.

DMD UTRN

4.84e-0627729713852
Pubmed

Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

CREBBP STAT1

4.84e-0627729037008
Pubmed

STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.

STAT1 STAT4

4.84e-06277224920804
Pubmed

Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy.

DMD UTRN

4.84e-06277225607927
Pubmed

Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency?

DMD UTRN

4.84e-0627728021701
Pubmed

Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.

DMD UTRN

4.84e-06277226974331
Pubmed

Developmental studies of dystrophin-positive fibers in mdx, and DRP localization.

DMD UTRN

4.84e-0627728433092
Pubmed

Second-generation compound for the modulation of utrophin in the therapy of DMD.

DMD UTRN

4.84e-06277225935002
Pubmed

Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice.

DMD UTRN

4.84e-06277216024571
Pubmed

Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.

DMD UTRN

4.84e-06277228453658
Pubmed

A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.

DMD UTRN

4.84e-06277211801396
Pubmed

Apo-dystrophin-1 and apo-dystrophin-2, products of the Duchenne muscular dystrophy locus: expression during mouse embryogenesis and in cultured cell lines.

DMD UTRN

4.84e-0627727987307
Pubmed

Utility of dystrophin and utrophin staining in childhood muscular dystrophy.

DMD UTRN

4.84e-06277216295426
Pubmed

Comparative analysis of the human dystrophin and utrophin gene structures.

DMD UTRN

4.84e-06277211861579
Pubmed

Distinct mechanical properties in homologous spectrin-like repeats of utrophin.

DMD UTRN

4.84e-06277230914715
Pubmed

Dystrophin is a microtubule-associated protein.

DMD UTRN

4.84e-06277219651889
Pubmed

Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice.

DMD UTRN

4.84e-0627729590295
Pubmed

Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains.

DMD UTRN

4.84e-06277222284942
Pubmed

Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.

DMD UTRN

4.84e-06277229879154
Pubmed

Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.

DMD UTRN

4.84e-06277217889902
Pubmed

Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion.

DMD UTRN

4.84e-06277212370193
Pubmed

Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models.

DMD UTRN

4.84e-06277232025735
Pubmed

Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.

DMD UTRN

4.84e-06277227836895
Pubmed

BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.

DMD UTRN

4.84e-06277227750047
Pubmed

cDNA cloning, expression and chromosome mapping of the human STAT4 gene: both STAT4 and STAT1 genes are mapped to 2q32.2-->q32.3.

STAT1 STAT4

4.84e-0627729284918
Pubmed

Prevention of dystrophin-deficient cardiomyopathy in twenty-one-month-old carrier mice by mosaic dystrophin expression or complementary dystrophin/utrophin expression.

DMD UTRN

4.84e-06277217967782
Pubmed

Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.

DMD UTRN

4.84e-06277221062902
Pubmed

Matricellular Protein CCN5 Gene Transfer Ameliorates Cardiac and Skeletal Dysfunction in mdx/utrn (±) Haploinsufficient Mice by Reducing Fibrosis and Upregulating Utrophin Expression.

DMD UTRN

4.84e-06277235557546
Pubmed

Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.

DMD UTRN

4.84e-06277237626761
Pubmed

Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin.

DMD UTRN

4.84e-06277215565469
Pubmed

The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.

DMD UTRN

4.84e-06277226516677
Pubmed

Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging.

DMD UTRN

4.84e-06277222209498
Pubmed

A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.

DMD UTRN

4.84e-06277237108685
Pubmed

Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.

DMD UTRN

4.84e-06277210694796
Pubmed

Dystrophin and dystrophin-related protein in the central nervous system of normal controls and Duchenne muscular dystrophy.

DMD UTRN

4.84e-0627728171962
Pubmed

Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.

DMD UTRN

4.84e-06277227822449
Pubmed

Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model.

DMD UTRN

4.84e-06277233651713
Pubmed

Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.

DMD UTRN

4.84e-06277222275054
Pubmed

NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

DMD UTRN

4.84e-06277227798264
Pubmed

Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice.

DMD UTRN

4.84e-06277231506484
Pubmed

Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy.

DMD UTRN

4.84e-0627729288752
Pubmed

Utrophin-dystrophin-deficient mice as a model for Duchenne muscular dystrophy.

DMD UTRN

4.84e-0627729288751
Pubmed

Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.

DMD UTRN

4.84e-06277224337461
Pubmed

Combined gene therapy via VEGF and mini-dystrophin synergistically improves pathologies in temporalis muscle of dystrophin/utrophin double knockout mice.

DMD UTRN

4.84e-06277233987645
Pubmed

Activation of calcineurin and stress activated protein kinase/p38-mitogen activated protein kinase in hearts of utrophin-dystrophin knockout mice.

DMD UTRN

4.84e-06277211297940
Pubmed

Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice.

DMD UTRN

4.84e-06277229408646
Pubmed

Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.

DMD UTRN

4.84e-06277222388933
Pubmed

Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.

DMD UTRN

4.84e-06277225642938
Pubmed

Activation of non-myogenic mesenchymal stem cells during the disease progression in dystrophic dystrophin/utrophin knockout mice.

DMD UTRN

4.84e-06277225859011
Pubmed

Disease Risk-Associated Genetic Variants in STAT1 and STAT4 Function in a Complementary Manner to Increase Pattern-Recognition Receptor-Induced Outcomes in Human Macrophages.

STAT1 STAT4

4.84e-06277232661180
Pubmed

Chromosomal localization and genomic characterization of the mouse melastatin gene (Mlsn1).

MITF TRPM1

4.84e-0627729806836
Pubmed

Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice.

DMD UTRN

4.84e-06277215703201
Pubmed

Microtubule binding distinguishes dystrophin from utrophin.

DMD UTRN

4.84e-06277224706788
Pubmed

Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region.

STAT1 STAT4

4.84e-06277218803832
Pubmed

Utrophin suppresses low frequency oscillations and coupled gating of mechanosensitive ion channels in dystrophic skeletal muscle.

DMD UTRN

4.84e-06277225941878
Pubmed

Regulating type 1 IFN effects in CD8 T cells during viral infections: changing STAT4 and STAT1 expression for function.

STAT1 STAT4

4.84e-06277222968462
Pubmed

Duchenne muscular dystrophy and the neuromuscular junction: the utrophin link.

DMD UTRN

4.84e-0627729297964
Pubmed

Dystrophin and utrophin do not play crucial roles in nonmuscle tissues in mice.

DMD UTRN

4.84e-06277210204788
Pubmed

SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.

DMD UTRN

4.84e-06277225652448
Pubmed

Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.

DMD UTRN

4.84e-06277228785010
Pubmed

CBP/p300 as a co-factor for the Microphthalmia transcription factor.

MITF CREBBP

4.84e-0627729223672
Pubmed

Methylation specifies distinct estrogen-induced binding site repertoires of CBP to chromatin.

NCOA3 CREBBP

4.84e-06277221632823
Pubmed

The role of proteases in excitation-contraction coupling failure in muscular dystrophy.

DMD UTRN

4.84e-06277225298424
Pubmed

Restoration of all dystrophin protein interactions by functional domains in trans does not rescue dystrophy.

DMD UTRN

4.84e-06277216307000
Pubmed

Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice.

DMD UTRN

4.84e-06277221949353
Pubmed

Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.

DMD UTRN

4.84e-06277223097179
Pubmed

rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

DMD UTRN

4.84e-06277216819550
Pubmed

The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCs) in the choroid plexus and microvasculature of the brain.

DMD UTRN

4.84e-06277215501597
Pubmed

Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.

DMD UTRN

4.84e-06277211257121
Pubmed

Characterization of dystrophin and utrophin diversity in the mouse.

DMD UTRN

4.84e-06277210072426
Pubmed

Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA.

STAT1 STAT4

4.84e-0627729630226
Pubmed

The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin.

DMD UTRN

4.84e-0627729625743
Pubmed

The correlation of TRPM1 (Melastatin) mRNA expression with microphthalmia-associated transcription factor (MITF) and other melanogenesis-related proteins in normal and pathological skin, hair follicles and melanocytic nevi.

MITF TRPM1

4.84e-06277220482673
Pubmed

Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice.

DMD UTRN

4.84e-06277218973234
Pubmed

Metabolic profiles of dystrophin and utrophin expression in mouse models of Duchenne muscular dystrophy.

DMD UTRN

4.84e-06277212387876
InteractionLHX5 interactions

SRGAP1 SRGAP2 DMD

8.32e-0611763int:LHX5
InteractionYWHAH interactions

KIF21B NCOA3 PHF3 SRGAP1 ARL6IP5 CNTRL MITF NELFB RICTOR SRGAP2 KIF5C CCDC6 PIBF1 UTRN CREBBP

1.30e-0511027615int:YWHAH
InteractionUSP21 interactions

TRIM9 SYNE1 SRGAP2 UPF3B ESPL1 UTRN

3.26e-05161766int:USP21
InteractionPCNT interactions

SYNE3 SYNE1 CNTRL SRGAP2 KIF5C PIBF1 UTRN

3.47e-05241767int:PCNT
Cytoband1q32.1

KIF21B SRGAP2 PLEKHA6

8.16e-041087731q32.1
CytobandEnsembl 112 genes in cytogenetic band chr1q32

KIF21B LPGAT1 SRGAP2 PLEKHA6

1.47e-03290774chr1q32
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

DMD UTRN CREBBP

1.22e-051846391
GeneFamilySpectrin repeat containing nuclear envelope family

SYNE3 SYNE1

3.79e-0544621252
GeneFamilyYIP family

ARL6IP5 PRAF2

6.30e-0554621144
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

NCOA3 CREBBP

8.41e-0417462486
GeneFamilyRho GTPase activating proteins|F-BAR domain containing

SRGAP1 SRGAP2

1.55e-03234621288
GeneFamilyKinesins|Pleckstrin homology domain containing

KIF21B KIF5C

6.10e-0346462622
GeneFamilyRho GTPase activating proteins|BCH domain containing

SRGAP1 SRGAP2

7.18e-0350462721
GeneFamilyX-linked mental retardation|Angiotensin receptors

UPF3B DMD

8.04e-0353462103
CoexpressionGSE38696_LIGHT_ZONE_VS_DARK_ZONE_BCELL_UP

KIF21B LIAS SYNE1 SESN3 UTRN STAT1

1.73e-05184776M9005
CoexpressionGSE20727_CTRL_VS_H2O2_TREATED_DC_DN

TMEM260 ZFHX3 KIF5C DMD UTRN DDX39B

2.47e-05196776M9243
CoexpressionBUSSLINGER_GASTRIC_IMMUNE_CELLS

KIF21B NCOA3 PHF3 SYNE1 ARL6IP5 CNTRL RPS15 SESN3 LPGAT1 RICTOR BIRC6 UTRN CREBBP STAT1 STAT4

2.48e-0514927715M40023
CoexpressionGSE17721_LPS_VS_PAM3CSK4_24H_BMDC_DN

POSTN MAT2A ZFHX3 MRPL33 PLEKHA6 DDX39B

2.77e-05200776M3931
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

NCOA3 PHF3 MITF ZFHX3 SRGAP2 KIF5C DMD CCDC6 PIBF1 CREBBP C2CD2

3.95e-058567711M4500
CoexpressionSCHLOSSER_SERUM_RESPONSE_DN

TRIM9 PHF3 SNAPC5 LPGAT1 MRPL33 SRGAP2 MINPP1 PIBF1 CREBBP STAT1

4.02e-057057710M1410
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 ZFHX3 GRIN2A DMD UTRN C2CD2

8.29e-0718577651dfe6ac7df8b330343b37e3bee71e5c65267189
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 ZFHX3 GRIN2A DMD UTRN C2CD2

8.29e-07185776a8c02cec3c414f3a0da9f2d6d28ce563b0030705
ToppCellcritical-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FILIP1 SYNE1 CNTRL LCA5L DRC1 CCDC180

1.23e-06198776ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN FILIP1 TRIM9 GRIN2A DMD

1.22e-051727751ef243bce63d841c25e4b74d029d1377f84bcc3d
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN FILIP1 TRIM9 GRIN2A DMD

1.22e-05172775ab1c81be29f93ca8920c6ab5ab92f497a9256d3f
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-ectodermal/neuroectodermal-like_cells|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.

ORC1 FLII LCA5L SGO2 DRC1

1.25e-051737757e4a2f5f92fbed16406bd097c0119278e4053245
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FILIP1 SYNE1 CNTRL UTRN STAT1

1.44e-0517877501dafd19de04eff459253eaa9a35debf8f3deedf
ToppCelldroplet-Kidney-KIDNEY-30m-Lymphocytic-Epcam____thick_ascending_tube_S_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SGO2 PIBF1 ESPL1 STAT4 ME3

1.48e-051797754166c4e1a8748a79ac6a11fd0b97c5344be2321b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 TRIM9 ECM2 GRIN2A DMD

1.60e-0518277544764676ed3f51ba171ce63f669390392fa50a43
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP2_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

POSTN SLITRK2 TRIM9 KIF5C GASK1B

1.60e-05182775f7f9be9c7ef8da9864d6aefe20043b26e1bb8697
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 TRIM9 ECM2 GRIN2A DMD

1.60e-05182775d82f59a3f930a840dde27dc6ab024f227a26d446
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro2_(5)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

POSTN TRIM9 PXDNL SESN3 ZFHX3

1.78e-051867757def03dd856b765bd3f493288641981c4f7fd26e
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 SYNE1 SRGAP1 GRIN2A DMD

1.97e-051907751121eb607a984c59fbffe7220837fc178745aa55
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 SYNE1 SRGAP1 GRIN2A DMD

1.97e-05190775048b581e3f7ea9fc2f87c0532974bba85c7292c2
ToppCellcontrol-Lymphoid-B_cell|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

NCOA3 SYNE3 SESN3 SRGAP2 WDFY4

2.17e-05194775a5284adca931a78b1c4592925c4860853ebd24f1
ToppCellRA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

FILIP1 PXDNL MITF DMD STAT4

2.17e-0519477589812fb164065041357bb37a3c2d87028ec3de4e
ToppCellmoderate-Epithelial-Ciliated|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

FILIP1 SYNE1 LCA5L DRC1 CCDC180

2.23e-051957753486eae5fdb062a75a907b896c9d7b396d2aa195
ToppCellLPS_IL1RA_TNF|World / Treatment groups by lineage, cell group, cell type

PXDNL SYNE1 UTRN SYT13 STAT1

2.34e-051977750a6550dce156fc81f15b1e7830d331ca50d87d06
ToppCellPSB-critical-LOC-Epithelial-Ciliated|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FILIP1 SYNE1 LCA5L DRC1 CCDC180

2.34e-051977756865f4831eb23794fb88a8649d48d497bbae3f44
ToppCellsevere-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

SYNE1 SESN3 UTRN DDX39B STAT4

2.34e-0519777557ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 SYNE1 SRGAP1 DMD UTRN

2.34e-051977759b480f9c799a244bfee64487abd8a1bf07c9a3a2
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PHF3 SYNE1 ARL6IP5 RICTOR DDX39B

2.40e-051987754c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellmild-low-quality_cells|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF3 SYNE1 RICTOR UTRN STAT4

2.46e-05199775f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCellmild-MAIT|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

PHF3 SYNE1 KIF5C UTRN STAT4

2.46e-05199775cbe1fb6d2c5fca7a1baf1ad20afcdf8e8e11bd84
ToppCellmild-cDC|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

MAT2A ZFHX3 SRGAP2 CCDC6 WDFY4

2.52e-0520077586f585bf9066b179bbcbc703bf43f15da4a07284
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Neuronal-Intermediate|1m / Sample Type, Dataset, Time_group, and Cell type.

LRRN1 RPS15 ZFHX3 KIF5C C2CD2

2.52e-05200775805f50236113713b02f77aa5e208efb3b3b959d5
ToppCellTCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Poorly_Differentiated_or_Epithelioid_Leiomyosarcoma-2|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9

TRIM9 RICTOR GRIN2A CCDC6

5.08e-0511777494f511dbf639b164c4b096195db312ecee3ee176
ToppCellPND07-28-samps-Mesenchymal-Matrix_fibroblast-mesenchymal_C|PND07-28-samps / Age Group, Lineage, Cell class and subclass

TRPM1 PLEKHA6 NOL9 DMD

5.79e-05121774176de42c088988fe1a7838f96add26ee8a30e543
ToppCellPBMC-Control-Lymphocyte-B-B_cell-B_naive-B_activate-7|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SERHL2 DMD CCDC180 WDFY4

9.64e-0513877476be06136c83c167cedece7515228ed4d29dd1f0
ToppCell10x5'-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

FILIP1 GARNL3 SRGAP1 WDFY4

1.05e-041417747671d300b1722711fd2d8034b96a3aa7e3ccb560
ToppCell368C-Fibroblasts-Fibroblast-F|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ORC1 LRRN1 PXDNL NOL9

1.30e-04149774f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCell368C-Fibroblasts-Fibroblast-F-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ORC1 LRRN1 PXDNL NOL9

1.30e-041497749286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCellIIH-CD8-memory_CD4|IIH / Condition, Cell_class and T cell subcluster

FILIP1 SGO2 CCDC6 STAT4

1.55e-04156774e312fc4317d966fb2b570d1a4a3aa865f781ea93
ToppCell368C-Fibroblasts-Fibroblast-F|368C / Donor, Lineage, Cell class and subclass (all cells)

ORC1 LRRN1 PXDNL NOL9

1.58e-0415777474038192f016f95f80e0189035ee8ccc22ceb1b8
ToppCell368C-Fibroblasts-Fibroblast-F-|368C / Donor, Lineage, Cell class and subclass (all cells)

ORC1 LRRN1 PXDNL NOL9

1.58e-04157774982e6ea78c7dabdb7c07c4a5fb2425d5e45b5b94
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN TRIM9 SYNE1 STAT4

1.66e-041597745ca96db4281abb5f646150ccf36adc66ab201c78
ToppCellPBMC-Severe-cDC_4|Severe / Compartment, Disease Groups and Clusters

KIF21B TMEM201 CCDC171 C2CD2

1.70e-041607744dac64e58d9366c399f3d830848ccb720d400be7
ToppCellmild_COVID-19_(asymptomatic)-B_intermediate|World / disease group, cell group and cell class (v2)

NCOA3 PXDNL DMD WDFY4

1.70e-041607746722934e153b72039c3c4308557d0ef879a30638
ToppCellsevere_influenza-cDC|World / disease group, cell group and cell class (v2)

TRIM9 MAT2A LCA5L ME3

1.74e-04161774802f8cafb5f499e3b2ec0193d6eb1ac9320b9287
ToppCellfacs-Thymus-Thymus_Flowthrough-18m|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA3 ARL6IP5 BIRC6 STAT1

1.79e-041627747e6d20704d77b28512690f882f9ddbbd9c5c3228
ToppCellfacs-Thymus-Thymus_Flowthrough|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NCOA3 ARL6IP5 BIRC6 STAT1

1.79e-041627742c193f766f2cefe67682f34325d1de6aed778f49
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN4|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SESN3 DRC1 UTRN STAT1

2.01e-0416777410c9fab3573c2948081aac2cec1798e46e59e38a
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FILIP1 ZFHX3 UTRN GASK1B

2.01e-04167774a6ff7a3d9b80839c0efa91658836812e868561fa
ToppCelldroplet-Thymus-nan-3m-Lymphocytic-DN4_thymocyte|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SESN3 DRC1 UTRN STAT1

2.10e-041697742de213b083f57f47be58427c0ce127fee9f85caa
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_SLITRK6|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

MITF ZFHX3 UTRN GASK1B

2.10e-041697741c9e54e7b14eb99996590fb93b257cf881a9f184
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ORC1 FILIP1 GRIN2A DMD

2.15e-04170774fa753cc8fbd04e63c9a303da4dc17ee2ce907f92
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Regulatory_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTRL SESN3 UTRN STAT4

2.15e-04170774064786c1f1ad7665358964765910b0ad46d14685
ToppCellsaliva-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c04-SOX5-TNFRSF1B|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MTG1 CNTRL ERCC6L2 WDFY4

2.15e-0417077432917888c3f1d54302675c1d4de1fd3b7c79af5f
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Fibroblast-Collagen+matrisome-high_fibroblast-|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

ORC1 FILIP1 GRIN2A DMD

2.15e-0417077403044e1436443b28dd39d5ef4fdb25c18e3a7546
ToppCelldroplet-Lung-nan-18m-Lymphocytic-regulatory_T_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CNTRL SESN3 UTRN STAT4

2.15e-041707746725747df336697708b94999b3ebb40f1721da16
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN TRIM9 SYNE1 STAT4

2.15e-04170774876b84740e15399bfff2b9c7f0b80fd759bbdb3f
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN TRIM9 SYNE1 STAT4

2.15e-041707741f8738acf439d893880db7e1fdc9b3615ca00c39
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-10|TCGA-Brain / Sample_Type by Project: Shred V9

ECM2 USP29 DRC1 WDFY4

2.20e-0417177474be8d3bf6b99e2d734635a8b1a7c41e8c596959
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8|lymph-node_spleen / Manually curated celltypes from each tissue

SYNE1 SESN3 UTRN STAT4

2.20e-041717742e9a20f8980b78325c52065a9c14ab3656267c05
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2-Exc_L6_FEZF2_KRT17|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FILIP1 ZFHX3 UTRN GASK1B

2.25e-04172774adc09c4d1b63fe84150516beb692db1e7f7ac980
ToppCellBac-SEP-Myeloid-cDC1|Bac-SEP / Disease, Lineage and Cell Type

PLEKHA6 DMD CCDC6 WDFY4

2.30e-04173774f88269327441858ddb8c49b9dd619b76fd53b1da
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 ECM2 ZFHX3 UTRN

2.30e-04173774fc2602b2ce051cd4c33957d7e3d041ff8a529883
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)

CNTRL LPGAT1 CCDC6 WDFY4

2.30e-04173774d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCellnucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GARNL3 PXDNL ZFHX3 DMD

2.30e-04173774cb6389536195443633adb06e5f1b7483530773d1
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 ECM2 ZFHX3 UTRN

2.30e-04173774901b8e6909c1f3849906fad9cee17b8f0bab050d
ToppCellE16.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POSTN ECM2 ZFHX3 ESPL1

2.40e-04175774fa16c6ba08dc0cc22e8cf049db0577811d080df6
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN SLITRK2 SYNE1 KATNIP

2.40e-0417577412f5fd83c7710fc0c77406f765d9cbd133433b8b
ToppCellE18.5-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_G2M|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

POSTN ECM2 SGO2 ZFHX3

2.40e-041757743e56695a9db97cb1d3503425c48eb79bbf99213e
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIF21B NCOA3 SYNE3 WDFY4

2.45e-04176774274458d80f9f3f080248cbf64e4784ef351e7254
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FILIP1 ZFHX3 UTRN GASK1B

2.45e-04176774ed421d8525108d2f585265d2cf777f07b29f44f0
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Immune-Lymphocytic_B-B_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIF21B NCOA3 SYNE3 WDFY4

2.45e-04176774d0a3e176df1270968efa79c00dc941c5e1c4f7aa
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

POSTN SLITRK2 TRIM9 GASK1B

2.50e-0417777459726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellControl-Fibroblasts-Airway_smooth_muscle|Control / group, cell type (main and fine annotations)

GARNL3 PXDNL ZFHX3 DMD

2.67e-04180774d0de12749ef0f51f0931c6e7b9b99966bdbc3ec1
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L3-4_PVALB_HOMER3|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

POSTN PXDNL MITF UTRN

2.73e-04181774bd7e9437839bca543ca5945df43d6525e6a312a8
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLITRK2 TRIM9 DMD GASK1B

2.73e-041817741aebb62ed4439db444ee9d30688212b86ee3d9ef
ToppCell(2)_NK/T-(230)_CD4+/CD25+_Reg_T_cell|(2)_NK/T / immune cells in Peripheral Blood (logTPM normalization)

CNTRL RPS15 SESN3 WDFY4

2.73e-04181774ad14c7111d4fb924afd233cb114447f195373a7c
ToppCellPCW_10-12-Neuronal-Neuronal_postreplicative-neuro_NA|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLITRK2 TRIM9 DMD GASK1B

2.73e-041817746aee2ddee4790250ef3b2ef0038bd9839925c995
ToppCellPCW_10-12-Neuronal|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

SLITRK2 TRIM9 DMD GASK1B

2.73e-04181774381b553e2cae65ce6be100662a5f9f963353840c
ToppCell10x5'v1-week_12-13-Myeloid_neutrophil-granulo-neutrophil-myelocyte|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

LRRN1 SYNE1 LPGAT1 DRC1

2.78e-0418277452eac2f892ea7f26731e0b21c578fd2665a1657a
ToppCell3'-GW_trimst-1-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

POSTN SLITRK2 SESN3 GASK1B

2.84e-04183774547b1fb9f9940cfc8d6e351d96acc0da44def57e
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Mesenchymal-Myocytic_interstitial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 ECM2 DMD C2CD2

2.84e-04183774667717366cb181b8a04a347e64f0f5a4dfc6ee7f
ToppCell(2)_5-FU-(4)_COL2.3+_osteoblasts|World / Stress and Cell class

POSTN ECM2 ZFHX3 PRAF2

2.90e-04184774684d05340a3dfb8aa08b881516a37f9627a10448
ToppCelldroplet-Marrow-nan-3m|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PHF3 CNTRL BIRC6 UTRN

2.90e-041847741154a5ad7b8512272b7476f949ddac350910bfb7
ToppCellLV-15._Ventricular_Cardiomyocyte_III|LV / Chamber and Cluster_Paper

FILIP1 PXDNL MITF DMD

2.90e-04184774ab7a1620c14a9d9b6be1b47c559931e345e9eef8
ToppCellBac-SEP-Lymphocyte-T_NK-T_NK_proliferative|Bac-SEP / Disease, Lineage and Cell Type

ORC1 FILIP1 TRIM9 SGO2

2.90e-04184774848d05afd5a2ef61fb8a09c0f5fa2a56fd5c160b
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-MatrixFB_->_Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

POSTN LRRN1 DMD CCDC171

2.96e-041857746712512100ccef456d2e2bd201d0987986c92ac9
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_proliferating_SCP1_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

POSTN SLITRK2 TRIM9 KIF5C

2.96e-04185774a8946379fc066903fe8f4bc9cbf693b7b424a0cd
ToppCellCOVID-19-lung-B_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

NCOA3 CNTRL SESN3 WDFY4

2.96e-04185774e8f1ad580f19705b5ca1d7d8867b2125f4891684
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC1 TRPM1 UTRN STAT4

3.02e-041867744dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCell5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLITRK2 SESN3 DMD GASK1B

3.02e-041867746f88b68735d0f7c9904eb8413e6007910d556185
ToppCelldroplet-Spleen-SPLEEN-30m-Lymphocytic-B_cell|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

MAT2A RPS15 LPGAT1 WDFY4

3.02e-04186774e3807508a5da6c8c7081129a5f785ccecaf5ebba
ToppCellfacs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DRC1 TRPM1 UTRN STAT4

3.02e-04186774e23e1246914e230369a716d0d666b98383bf8512
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN FILIP1 TRIM9 SYNE1

3.09e-04187774d591a3c216997663ab77710fed0d230ffc37e41a
ToppCellPCW_05-06-Neuronal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

POSTN SLITRK2 TRIM9 KIF5C

3.09e-0418777403a2ed85b171c887d4f3b0f4fe2e1cb4a853e658
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 DMD C2CD2 STAT4

3.09e-04187774ec4b694487cc446999c7b27b119950a4f252c4b3
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN FILIP1 TRIM9 SYNE1

3.09e-04187774d1dc8c9a2c2cd10c640257161a75e7730ec5bb41
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN FILIP1 TRIM9 SYNE1

3.09e-04187774ac8e092b37e042975e2ee057d3f7c6821e58e8b5
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN FILIP1 TRIM9 SYNE1

3.09e-0418777415d6e158562d7d85af3ceaf955439b379c8fce81
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLII ECM2 PRAF2 CCDC180

3.09e-041877743699d5e71d779da922920aa3160895db187bf81b
ToppCellE18.5-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLII ECM2 PRAF2 CCDC180

3.09e-04187774033ba52c0c2f9978784947098fa697368ae44834
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FILIP1 DMD C2CD2 STAT4

3.09e-04187774530e4e6d91b5c0d9aa4543caa2b734a1674c5788
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Mesenchymal-glomerular_mesenchymal_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

POSTN FILIP1 TRIM9 SYNE1

3.09e-04187774f62074b631fd45ad299c69d71b09267b04d656ee
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Macrophage_Dendritic-Cycling_Mononuclear_Phagocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

CNTRL SGO2 ESPL1 WDFY4

3.09e-0418777473931a5ea73799095daff100b5f18853c57c74dc
ToppCell5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

GARNL3 LRRN1 VTCN1 RICTOR

3.09e-04187774f5a202d5f8eb57b57d80815ce98774e04c387383
ToppCellLA-03._Atrial_Cardiomyocyte|World / Chamber and Cluster_Paper

FILIP1 MITF DMD STAT4

3.15e-041887746d249fe92d51a19da19ec14bb2262d394255d577
DiseaseThyroid cancer, nonmedullary, 2

SRGAP1 MINPP1

3.92e-054762cv:C4225426
DiseaseTHYROID CANCER, NONMEDULLARY, 2

SRGAP1 MINPP1

3.92e-054762188470
DiseaseTHYROID CANCER, NONMEDULLARY, 2

SRGAP1 MINPP1

6.51e-055762C4225426
DiseaseDuchenne and Becker Muscular Dystrophy

POSTN DMD

6.51e-055762C3542021
DiseaseBecker Muscular Dystrophy

POSTN DMD

6.51e-055762C0917713
Diseaseinfluenza A (H1N1)

SERHL2 PXDNL MITF DMD

7.69e-0587764EFO_1001488
DiseaseMuscular Dystrophy, Duchenne

POSTN DMD

9.75e-056762C0013264
DiseaseThyroid cancer, follicular

SRGAP1 MINPP1

1.36e-047762C2931367
Diseaseattention deficit hyperactivity disorder, unipolar depression, bipolar disorder, autism spectrum disorder, schizophrenia

KIF21B SYNE1 GRIN2A KIF5C

1.37e-04101764EFO_0003756, EFO_0003761, EFO_0003888, MONDO_0004985, MONDO_0005090
Diseasethyroid gland papillary carcinoma (is_implicated_in)

SRGAP1 MINPP1

2.91e-0410762DOID:3969 (is_implicated_in)
Diseaselymphangioleiomyomatosis (is_marker_for)

RICTOR STAT1

4.25e-0412762DOID:3319 (is_marker_for)
DiseaseMicrocephaly

ORC1 NUP214 KIF5C

6.99e-0467763C0025958
Diseasesevere acute respiratory syndrome, COVID-19

DRC1 ZFHX3 SRGAP2 TRPM1 DMD WDFY4

1.04e-03447766EFO_0000694, MONDO_0100096
Diseasemuscular dystrophy (implicated_via_orthology)

DMD UTRN

1.33e-0321762DOID:9884 (implicated_via_orthology)
DiseaseJoubert syndrome 1

KATNIP PIBF1

1.33e-0321762C4551568
DiseaseJT interval, response to sulfonylurea

STAT1 ME3

1.60e-0323762EFO_0007885, EFO_0007922
Diseasebreast cancer (implicated_via_orthology)

NCOA3 STAT1

1.89e-0325762DOID:1612 (implicated_via_orthology)
DiseaseHVA measurement

GARNL3 DRC1

2.04e-0326762EFO_0005131
Diseasetriglyceride measurement, response to escitalopram, response to citalopram

VTCN1 CCDC171

2.20e-0327762EFO_0004530, EFO_0006329, EFO_0007871
DiseaseAdenoid Cystic Carcinoma

XAGE1A ESPL1 CREBBP

2.22e-03100763C0010606
Diseaseobesity (implicated_via_orthology)

FLII ZFHX3 STAT1 STAT4

2.33e-03215764DOID:9970 (implicated_via_orthology)
Diseaseimmune system disease

TRPM1 STAT4

2.37e-0328762EFO_0000540
Diseasechronic obstructive pulmonary disease (biomarker_via_orthology)

STAT1 STAT4

2.37e-0328762DOID:3083 (biomarker_via_orthology)
Diseasebipolar disorder (is_implicated_in)

SYNE1 GRIN2A

2.54e-0329762DOID:3312 (is_implicated_in)

Protein segments in the cluster

PeptideGeneStartEntry
ANRLLVVLIKAKNLH

SYT13

301

Q7L8C5
KQLSGRLQLVNKLRQ

CNTRL

496

Q7Z7A1
IRKQLVHHKQQLNLL

BIRC6

2231

Q9NR09
QRKVLHLEKQNLSLL

CREB3L3

286

Q68CJ9
ILALARNKSLNLKHI

DDX39B

176

Q13838
KDQSLRQLNRHLTQL

CCDC171

1101

Q6TFL3
IKHKLRQQQIQHRLQ

CREBBP

1846

Q92793
RLKKQLRAAQLQHSE

CCDC6

271

Q16204
QQLLQTKHNALKDLR

DMD

1851

P11532
LKTQNVLQQRRLKHL

CCDC180

386

Q9P1Z9
LQNHKDNSSIRKLLR

CPO

126

Q8IVL8
LKREARNLLKSHLNL

NOL9

191

Q5SY16
QKILLSQARRTQKHL

KANSL1L

231

A0AUZ9
KILNKILANRIQQHI

nan

541

O00370
KLRKLVLNKNHLVTL

FLII

341

Q13045
RDQQLLLLKKHLENN

LPGAT1

156

Q92604
LLQQRNRILKHLKSK

KATNIP

41

O60303
LAHKLNAKLAELRRN

MAT2A

156

P31153
RKESLQNLLHSSRKL

FAM91A1

751

Q658Y4
KSSLINSLRRQHLRK

MTG1

156

Q9BT17
LQKLQAAQKEHARLL

KIF21B

721

O75037
HITKQRNKNALLRLL

NELFB

431

Q8WX92
QRKRLNHLVDSLQQL

NUP214

871

P35658
AKHQNEVKNLRQLLR

LCA5L

201

O95447
NKLKNTLRNLNLHTV

LIAS

91

O43766
NRILNSLTLPNKKHR

RICTOR

1096

Q6R327
QQKRKINRLHDILNN

DRC1

336

Q96MC2
LNQKKRLQQLLQRAL

ING2

76

Q9H160
LQQILRSRLKHLKAF

ORC1

686

Q13415
LNTLLLNNNHIRKIS

PXDNL

76

A1KZ92
HRFLLQAVNQKNLLK

UPF3B

271

Q9BZI7
KSQHLRQKLLQSLFL

GASK1B

461

Q6UWH4
QLLTHLHRQLSKAQK

ESPL1

1631

Q14674
RILNKKLLSRHRNKN

C2CD2

671

Q9Y426
RQKIAITHKNKINRL

MRPL58

116

Q14197
KALHFLRLNNNKIRN

ECM2

631

O94769
ILAALRITKNKLSNH

ME3

316

Q16798
QLLNHCRKNRDKVLL

ERCC6L2

526

Q5T890
SLKQLLQRLLKSNSH

SERHL2

171

Q9H4I8
AIRNKLLLITRKHNK

GARNL3

606

Q5VVW2
LKNLLRLHLNSNKLK

LRRN1

166

Q6UXK5
RLHLNSNKLKVIDSR

LRRN1

171

Q6UXK5
KIRLQLLLLHTRYNK

UTRN

1831

P46939
NLITKLQAKHDLLQR

SRGAP1

451

Q7Z6B7
NFLLQHNIRKSKRNL

STAT1

76

P42224
NLQKRVTSILRRLKH

SYNE1

8091

Q8NF91
LLHNSLLQRKSKLQS

SYNE3

531

Q6ZMZ3
LLQRKSKLQSLLAQH

SYNE3

536

Q6ZMZ3
LANQESHNRQLRLKL

FILIP1

321

Q7Z7B0
NHQKKRATEILNLLL

KIF5C

541

O60282
HASLRLRNLKNKLEN

ARL6IP5

136

O75915
SLLQEKHRILHKLLQ

NCOA3

676

Q9Y6Q9
TLKRLHLNNNKLEIL

SLITRK2

111

Q9H156
KISLKHNNRALAQAL

SGO2

51

Q562F6
LLKSSNRRIQELHKL

TP53TG5

51

Q9Y2B4
NRGLRRKQHSLLKRL

RPS15

46

P62841
RHKKDSLQNQLINIR

PLEKHA6

586

Q9Y2H5
NRQKKLEHANRHLLL

MITF

376

O75030
VKQIRKLRQLHGLLQ

MINPP1

96

Q9UNW1
NTKRNRLREKLTLLH

MRPL33

31

O75394
VHASLRLRNLKNKIE

PRAF2

136

O60831
KRSLKLLKSHNLNVN

RMC1

141

Q96DM3
RLKNLNEINKLLAHR

SESN3

151

P58005
NLLLIHNLKRIRKVL

STAT4

76

Q14765
RNLITKLQAKHDLLQ

SRGAP2

461

O75044
KLNDALHQKQLLTLR

PIBF1

91

Q8WXW3
LHQKQLLTLRLDNQL

PIBF1

96

Q8WXW3
RKKASLLNHRIFQLI

WDFY4

1426

Q6ZS81
KKRQSHLRLTLKNNV

USP29

66

Q9HBJ7
LLLGLIIRQKLKRQH

PHF3

1341

Q92576
KHQNRQLRALLLSHQ

TMEM201

176

Q5SNT2
LRRLLEKHISLQKIN

TRPM1

226

Q7Z4N2
ALNRRKAQLLARVNK

TRIM9

326

Q9C026
LRLKAALHDQLNRLK

SNAPC5

16

O75971
LHLGSRQKKIRIQLR

XAGE1A

16

Q9HD64
NLKSSLSLINQKRRH

ZNF614

136

Q8N883
DQRLLKLILQNHILK

POSTN

421

Q15063
LKHLRKELQSLRNRK

TMEM260

691

Q9NX78
KRRSHLQLLNSKASL

VTCN1

246

Q7Z7D3
KHQRSESLRKLQRLQ

ZFHX3

1111

Q15911
ALQLQKNKLRISRQH

GRIN2A

1276

Q12879