Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionNAD transmembrane transporter activity

SLC25A52 SLC25A51

1.17e-045692GO:0051724
GeneOntologyBiologicalProcessmitochondrial NAD transmembrane transport

SLC25A52 SLC25A51

1.07e-052682GO:1990549
GeneOntologyBiologicalProcessregulation of mast cell activation

CD300LB CFTR CNR2

6.60e-0524683GO:0033003
GeneOntologyBiologicalProcesstrans-synaptic signaling, modulating synaptic transmission

NPTN GRM5 CNR2

8.44e-0526683GO:0099550
GeneOntologyBiologicalProcessNAD transmembrane transport

SLC25A52 SLC25A51

1.06e-045682GO:0035352
DomainC1Q

C1QTNF8 COL8A2

6.04e-0332682SM00110
DomainC1q

C1QTNF8 COL8A2

6.04e-0332682PF00386
DomainC1q_dom

C1QTNF8 COL8A2

6.80e-0334682IPR001073
DomainC1Q

C1QTNF8 COL8A2

6.80e-0334682PS50871
Pubmed

ZDHHC11 and ZDHHC11B are critical novel components of the oncogenic MYC-miR-150-MYB network in Burkitt lymphoma.

ZDHHC11B ZDHHC11

4.11e-06271228331227
Pubmed

SLC25A51 is a mammalian mitochondrial NAD+ transporter.

SLC25A52 SLC25A51

4.11e-06271232906142
Pubmed

Testis-specific hnRNP is expressed in colorectal cancer cells and accelerates cell growth mediating ZDHHC11 mRNA stabilization.

ZDHHC11B ZDHHC11

4.11e-06271235384384
Pubmed

The mitochondrial NAD+ transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions.

SLC25A52 SLC25A51

1.23e-05371235932995
Pubmed

ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.

ZDHHC11B ZDHHC11

1.23e-05371234897408
Pubmed

Localization of mGluR5, GABAB, GABAA, and cannabinoid receptors on the vago-vagal reflex pathway responsible for transient lower esophageal sphincter relaxation in humans: an immunohistochemical study.

GRM5 CNR2

1.23e-05371222256945
Pubmed

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid.

FZR1 WWP2

2.46e-05471227126000
Pubmed

ZDHHC11 modulates innate immune response to DNA virus by mediating MITA-IRF3 association.

ZDHHC11B ZDHHC11

2.46e-05471229429998
Pubmed

Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.

WWP2 SCN3A

4.09e-05571215548568
Pubmed

Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions.

CFTR CNGA2

4.09e-05571214604981
Pubmed

ZDHHC11 Positively Regulates NF-ÎșB Activation by Enhancing TRAF6 Oligomerization.

ZDHHC11B ZDHHC11

6.13e-05671234490261
Pubmed

In silico screening for palmitoyl substrates reveals a role for DHHC1/3/10 (zDHHC1/3/11)-mediated neurochondrin palmitoylation in its targeting to Rab5-positive endosomes.

ZDHHC11B ZDHHC11

8.57e-05771223687301
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

NPTN THADA POMGNT2 FOLR1 GNPTAB GPS1 ENTPD6 DNAJC1 DSE GPR107

1.58e-041201711035696571
Pubmed

Genetics of coronary artery calcification among African Americans, a meta-analysis.

ERBB4 PLD5 EMP1

1.68e-045271323870195
Pubmed

Interactions of ErbB4 and Kap1 connect the growth factor and DNA damage response pathways.

ERBB4 WWP2

3.16e-041371220858735
Pubmed

A mouse knockout library for secreted and transmembrane proteins.

ZDHHC11B TMC2 CD300LB REG3A EMP1 ZDHHC11

3.59e-0446071620562862
Pubmed

Cyclin B1/Cdk1 binds and phosphorylates Filamin A and regulates its ability to cross-link actin.

SLC25A52 SLC25A51

4.84e-041671217408621
Pubmed

A single cell transcriptional atlas of early synovial joint development.

COL8A2 EMP1

7.62e-042071232580935
Pubmed

PTPN14 is required for the density-dependent control of YAP1.

WWP2 WWC1

8.41e-042171222948661
Pubmed

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

C1QTNF8 EYS TMC2 C6orf89 CD300LB RIPK2 DHRSX ZDHHC11

8.85e-0498571812975309
Pubmed

The DNA sequence and analysis of human chromosome 6.

EYS C6orf89 CRISP1 KCNK16 ROS1 DSE

1.71e-0362271614574404
Cytoband6q22

ROS1 DSE

6.56e-0587126q22
Cytoband16q22.1

KCTD19 HPR WWP2

6.79e-0411071316q22.1
Cytoband5p15.33

ZDHHC11B ZDHHC11

1.14e-03327125p15.33
Cytoband3q25.1

SUCNR1 EIF2A

1.21e-03337123q25.1
CytobandEnsembl 112 genes in cytogenetic band chr16q22

KCTD19 HPR WWP2

2.92e-03183713chr16q22
GeneFamilyC2 and WW domain containing

WWP2 WWC1

3.79e-054462838
GeneFamilyZinc fingers DHHC-type|Ankyrin repeat domain containing

ZDHHC11B ZDHHC11

1.69e-032446276
CoexpressionGCNP_SHH_UP_LATE.V1_DN

NPTN ADAM7 GNPTAB DHRSX CNGA2 WWC1

8.24e-06178706M2640
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 FOLR1 TMEM59L ROS1 WWC1

2.37e-08194707c011cd59bb4ca4134331cba0f5d73bdbd7011d64
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FREM2 ERBB4 TMC2 ABCA5 ADAM7 ROS1

2.15e-07162706bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FREM2 MACC1 ERBB4 CFTR ROS1 WWC1

3.87e-07179706815b959ce8721c5ded70c0ca6e318dafc691746e
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FREM2 MACC1 ERBB4 CFTR ROS1 WWC1

4.85e-071867062ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCellControl-Epithelial-ATII|World / Disease state, Lineage and Cell class

FREM2 ERBB4 FOLR1 CFTR ROS1 WWC1

4.85e-07186706f4b6e401e19a71beddc73d8a1e08359f7c4025cf
ToppCellControl-Epithelial-ATII|Control / Disease state, Lineage and Cell class

FREM2 ERBB4 FOLR1 CFTR ROS1 WWC1

5.49e-07190706d50902a3abcc18aafa36d83cc2c6e07d7f7cb197
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 FOLR1 TMEM59L WWC1

5.49e-07190706c95032bb3ee2b3d40fdf48016acb46d6f78a48a6
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FREM2 MACC1 ERBB4 CFTR ROS1 WWC1

5.66e-07191706ca5669bd6f4a17471acae3eb229f845cc2e08efa
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 KCTD19 FOLR1 TMEM59L WWC1

5.84e-071927061aa5e4d9b32013a3f272561dcb8377f6805706df
ToppCellFetal_29-31_weeks-Epithelial|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

FREM2 MACC1 ERBB4 CFTR ROS1 WWC1

6.02e-07193706a0ca3231992f14abcf1a6129573bace320e89d2a
ToppCellPCW_05-06-Epithelial|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 FOLR1 TMEM59L WWC1

6.20e-0719470647a1369c22fcbfe00b08376eb610a61c355548db
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 FOLR1 TMEM59L ROS1 WWC1

6.39e-0719570698dd3b7d5ef587825dac052dea4d4ff883f6d4d6
ToppCellPCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM2 KCTD19 FOLR1 TMEM59L ROS1 WWC1

6.39e-07195706f08e41706680881ebd0afcd08a02f8ac0089f04e
ToppCellPCW_13-14-Epithelial-Epithelial_proliferating|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 TMEM59L ROS1 WWC1

6.58e-071967067b17d47b7758d8ccf9dbefd097aeb553791a1eed
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 KCTD19 FOLR1 TMEM59L ROS1 WWC1

6.78e-071977062f91b3870a7058168093a143110954c07588cfe9
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

FREM2 MACC1 ERBB4 CFTR ROS1

9.76e-06181705c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 FOLR1 WWC1

1.03e-05183705c5b10571599dc26476170b54b53f09c23e6b3117
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

FREM2 ERBB4 CFTR ROS1 WWC1

1.03e-051837056847c1252d6bb105524f812658112517fd351eab
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

FREM2 ERBB4 CFTR ROS1 WWC1

1.03e-051837058e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellCOVID-19-Epithelial_cells-AT2|COVID-19 / group, cell type (main and fine annotations)

FREM2 ERBB4 CFTR ROS1 WWC1

1.06e-05184705369b82f793deab672204558ae4e112cfa5aa9ccc
ToppCellControl-Epithelial-Club|World / Disease state, Lineage and Cell class

ERBB4 FOLR1 CFTR ROS1 WWC1

1.11e-051867059798428691408e17ff2af2fe2d1b345f074d67e4
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 TMEM59L ROS1 WWC1

1.11e-05186705bb0bfe9a015151be08a6ffc5d82896d0556d76de
ToppCellEpithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)|World / Lineage, Cell type, age group and donor

MACC1 ERBB4 CFTR ROS1 WWC1

1.14e-0518770581cc8435b2704a9a8287b3f54acaae0f11dd4ac7
ToppCellCOPD-Epithelial-ATII|COPD / Disease state, Lineage and Cell class

FREM2 ERBB4 CFTR ROS1 WWC1

1.17e-05188705eb6d79d733b53f64ca615bb777c64ed456866549
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 CFTR WWC1

1.20e-051897057659c7bbd58ee959a159294fb8d17317bbcc5681
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

FREM2 ERBB4 CFTR ROS1 WWC1

1.20e-05189705dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellIPF-Epithelial-Club|IPF / Disease state, Lineage and Cell class

ERBB4 FOLR1 CFTR ROS1 WWC1

1.20e-05189705f3fcef008ef252b29ac6d567fef27f9acf9cd70f
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 KCTD19 TMEM59L WWC1

1.23e-05190705625c08a0e5227efc46daa512fd579c3938ff76c7
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 FOLR1 WWC1

1.27e-0519170572dbd2e0fabfca8d6f604df35277d3574739a0b3
ToppCellEpithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)|World / Lineage, Cell type, age group and donor

FREM2 MACC1 ERBB4 CFTR WWC1

1.27e-05191705d3733c8c4bda70c4390e5601fdda6188a64be944
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

FREM2 ERBB4 CFTR ROS1 WWC1

1.27e-05191705a0332a4ef629510fb313ec119195c44a3f704a80
ToppCellCOVID-19-lung-AT2|lung / Disease (COVID-19 only), tissue and cell type

FREM2 ERBB4 CFTR ROS1 WWC1

1.27e-05191705276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCellPCW_07-8.5-Epithelial-Epithelial_proliferating-epi_proliferating3_(5)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 FOLR1 TMEM59L WWC1

1.30e-05192705d3634574b2e8d2ded6446969361b70761b331aea
ToppCellControl-Multiplet-Multiplet|World / Disease state, Lineage and Cell class

FREM2 ERBB4 FOLR1 ROS1 WWC1

1.30e-051927051bfd022d5b87cf8a5d5069f559339a553a52a0a2
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FREM2 ERBB4 CFTR ROS1 WWC1

1.30e-05192705cc9911e182a289779a2612bc213daae5607689e7
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 FOLR1 TMEM59L WWC1

1.30e-05192705b7c01e12b3e9be960a741b08835f1dfff65d0d47
ToppCellEpithelial|World / Lineage, Cell type, age group and donor

FREM2 ERBB4 CFTR ROS1 WWC1

1.30e-05192705499e8893afea5e6d3371e0bd018f7e86a524d669
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

FREM2 ERBB4 CFTR ROS1 WWC1

1.30e-0519270558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellPCW_05-06-Epithelial-Epithelial_proliferating|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 KCTD19 FOLR1 TMEM59L

1.33e-051937055f0eba7b1440beb891d94a288f7f18a4e13c3a88
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

FREM2 ERBB4 CFTR ROS1 WWC1

1.33e-05193705738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellPCW_07-8.5-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 FOLR1 TMEM59L WWC1

1.33e-05193705ab78fb1603ea6f720ba2d30148fe65dccf271fe1
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 CFTR TMEM59L

1.33e-05193705b25cdca3a1e381784ae48ca73c51cbb6ac62b811
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FREM2 ERBB4 CFTR ROS1 WWC1

1.33e-05193705fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellPCW_05-06-Epithelial-Epithelial_airway|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 FOLR1 WWC1

1.33e-05193705af6ec2c2ba92aef3e41531c3c7215b3300437bd9
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FREM2 ERBB4 CFTR ROS1 WWC1

1.33e-05193705f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 FOLR1 TMEM59L WWC1

1.36e-05194705c5ef4ff73b4e51530656002e3a2fb7264cdf533d
ToppCellPCW_05-06-Epithelial-Epithelial_airway-epi_proximal_secretory_(0)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 CFTR WWC1

1.36e-05194705b19e16a76d7342ff9a665d19c9151652916f17d4
ToppCellPCW_07-8.5-Epithelial|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 TMEM59L WWC1

1.36e-05194705f63ceedb88a9abc8644ee94adfd541e7817c1e3a
ToppCellPCW_07-8.5-Epithelial-Epithelial_airway|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 CFTR WWC1

1.36e-05194705f95c8dc242c9aebcadfe61b1ed033349cb7e5a88
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^medium_distal_(2)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 KCTD19 FOLR1 TMEM59L WWC1

1.36e-05194705413112ee8df7407fd418d57c2ff11aad3a6ec259
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 FOLR1 TMEM59L WWC1

1.36e-05194705acd5ba9a097595d4caab4f05440531c65a4aa7bc
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 TMEM59L ROS1 WWC1

1.36e-05194705c47fc3f716ab091a39c20d7639ac783029589ee5
ToppCellPCW_10-12-Epithelial-Epithelial_airway-epi_intermediate_(1)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 FOLR1 TMEM59L

1.40e-05195705d67a2b489c29bfd575751c13d2a5b1efdec5240a
ToppCellwk_20-22-Epithelial-Distal_epithelial-type_II_pneumocyte|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FREM2 FOLR1 CFTR TMEM59L ROS1

1.40e-0519570545d1acd316d0ced97dfb150c3a943128d8fa4e7e
ToppCellPCW_10-12-Epithelial-Epithelial_proliferating|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 FOLR1 TMEM59L WWC1

1.40e-05195705ce1ba5911e8a6ddb07434acc37147c38e94245ff
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal-epi_CTGF^high_distal_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 TMEM59L ROS1 WWC1

1.40e-0519570562d369a8af2b76a2553bc8ff9cb89a133b060123
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPTN ABCA5 SCN3A TMEM59L GRM5

1.43e-05196705676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellwk_20-22-Epithelial-Distal_epithelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

FREM2 FOLR1 CFTR TMEM59L ROS1

1.43e-05196705cd507ee2baf4f52d6498811b3510d3164b56311f
ToppCellPCW_10-12-Epithelial|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 TMEM59L WWC1

1.43e-051967059bfb31ff3e4f2c0a9405c418c86bfec5dbca23e2
ToppCellPCW_13-14-Epithelial-Epithelial_alveolar-distal|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 TMEM59L ROS1 WWC1

1.47e-051977056852a8ec1397811bbdd1fc625c52ed4fa75a931e
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 ERBB4 CFTR ROS1 WWC1

1.51e-051987052e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPTN ABCA5 SCN3A TMEM59L GRM5

1.51e-05198705c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellPCW_13-14-Epithelial|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

FREM2 MACC1 ERBB4 TMEM59L WWC1

1.51e-0519870548eb6f69a464a34ab32e8d425a22b9d45ec20428
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPTN ABCA5 SCN3A TMEM59L GRM5

1.51e-051987056d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 ERBB4 CFTR ROS1 WWC1

1.51e-05198705f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPTN ABCA5 SCN3A TMEM59L GRM5

1.51e-051987050ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 ERBB4 CFTR ROS1 WWC1

1.54e-05199705725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellBronchial-10x5prime-Epithelial-Epi_alveolar|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

FREM2 FOLR1 CFTR ROS1 WWC1

1.54e-05199705a38a981cffa61c8444a980916de7414e689a1b63
ToppCellParenchyma_COVID-19-Epithelial-TX-Transitional_AT2|Parenchyma_COVID-19 / Sample group, Lineage and Cell type

MACC1 FOLR1 ROS1 PLD5 WWC1

1.58e-05200705dfa897ef5ce4744c77b6e5ee5a0d6d83229d1691
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

NPTN ABCA5 SCN3A TMEM59L GRM5

1.58e-0520070548d801219bc771d6c7e151dc88ca4c179988de85
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Transitional_AT2|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MACC1 FOLR1 ROS1 PLD5 WWC1

1.58e-05200705992bd6b1feac2afded6eb927ac95ddf5cfef961c
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Transitional_AT2-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

MACC1 FOLR1 ROS1 PLD5 WWC1

1.58e-052007058d1c78dd829cbc290820d5118f24ff7f828a8622
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

FLG ERBB4 ZDHHC11B ABCA5

6.45e-0513770485b3a98039c1f68addad0334aa5b2584f6045aaa
ToppCellfacs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 ERBB4 TMC2 ROS1

8.04e-0514570496712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCellThalamus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Slc17a6-Rora-Excitatory_Neuron.Slc17a6.Rora.C1ql2_(Anterodorsal_thalamic_nucleus)|Thalamus / BrainAtlas - Mouse McCarroll V32

ROS1 MBOAT4 CNGA2

8.45e-05547038a8abf565ea657bf16059c51a63534ede3d7ac12
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 TMC2 DENND2C CNGA2

1.12e-04158704f296ca24fdedc33f1d24b79e7660763114ce7fa3
ToppCellfacs-Marrow-T-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FREM2 TMC2 DENND2C CNGA2

1.12e-041587048c7108f2c40d97a317762ba0b8eca76542b2ebaf
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nefm_(Neuron.Slc17a6.Nefm)-|Hippocampus / BrainAtlas - Mouse McCarroll V32

MACC1 TMC2 CD300LB

1.22e-046170302684156c41a06b4113117f43d11979db364ff03
ToppCellHippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Nefm_(Neuron.Slc17a6.Nefm)|Hippocampus / BrainAtlas - Mouse McCarroll V32

MACC1 TMC2 CD300LB

1.22e-04617036d7f00757654adf2f51905a3b12772e64aa3773a
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)-|368C / Donor, Lineage, Cell class and subclass (all cells)

FREM2 FOLR1 ROS1 ZDHHC11

1.29e-0416470485f53d184fa70e3eb1af655807f32b17ddbfb304
ToppCellfacs-Pancreas-Endocrine-24m-Epithelial-pancreatic_PP_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FOLR1 ADAM7 KCNK16 MBOAT4

1.29e-0416470474a35ba77e93d864161beb6b133d654473981bb7
ToppCell368C-Epithelial_cells-Epithelial-A_(AT2)|368C / Donor, Lineage, Cell class and subclass (all cells)

FREM2 FOLR1 ROS1 ZDHHC11

1.29e-04164704144ba070a1ede71684224cc6d4ead3b7e6a7b4c6
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FREM2 CFTR PLD5 WWC1

1.36e-041667041df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FREM2 CFTR PLD5 WWC1

1.36e-041667049628522e7af8f8edca733588a364ab2454ac5ca5
ToppCellPCW_05-06-Epithelial-Epithelial_alveolar-distal-epi_SFTPC^high_distal_(9)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

MACC1 KCTD19 FOLR1 WWC1

1.39e-0416770425af48c640e67848594f5902867ba325fc105da4
ToppCellTCGA-Pancreas|World / Sample_Type by Project: Shred V9

CFTR REG3A KCNK16 MBOAT4

1.42e-04168704279d5fcf9bd3f56ab560e37eed6fb3bd57dd93de
ToppCell343B-Fibroblasts-Fibroblast-H-|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ENTPD6 RIPK2 DHRSX PUS7L

1.55e-04172704709c6b77a7a52b873eefb6caca28a41291d384af
ToppCell343B-Fibroblasts-Fibroblast-H|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)

ENTPD6 RIPK2 DHRSX PUS7L

1.55e-04172704eb199c279fe8a2551121db37e9556893197d33ff
ToppCelldroplet-Marrow-nan-24m-Myeloid-basophil|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TUBGCP6 WDR7 SLC25A51 DSE

1.59e-041737046d2ceba4f89a228600e2b40aba81bb0eb81578c0
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)-|367C / Donor, Lineage, Cell class and subclass (all cells)

FOLR1 PLD5 ZDHHC11 WWC1

1.62e-04174704edf839d79ac58921f4e788f3b2cb2ae0d6af4b9e
ToppCell367C-Epithelial_cells-Epithelial-I_(AT1)|367C / Donor, Lineage, Cell class and subclass (all cells)

FOLR1 PLD5 ZDHHC11 WWC1

1.62e-0417470465539f69100db0b7d90b1b39ee15ab8281f86461
ToppCell3'-Child09-12-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TMC2 CFTR REG3A TMEM63A

1.66e-041757040431897d7fcc9cefb516cd36987cf18b7f19a26a
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_3_(BCAN+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ERBB4 DNAJC1 GRM5 TMEM63A

1.73e-04177704d05497d2c80a66ec6a4e1733fea3a5534877a6a7
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_D_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPTN FOLR1 SCN3A TMEM59L

1.81e-041797047c8a2fa1326c73dc9e774df645b572864fd97133
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)|390C / Donor, Lineage, Cell class and subclass (all cells)

ERBB4 FOLR1 CFTR WWC1

1.81e-04179704466da2bc3bfc534ffe111c8c28ece7a3cfa08051
ToppCell390C-Epithelial_cells-Epithelial-B_(AT2)-|390C / Donor, Lineage, Cell class and subclass (all cells)

ERBB4 FOLR1 CFTR WWC1

1.81e-04179704f4bdebb77d39e63160fbf3a85a340ce4d52b7cfd
ToppCell10x5'-GI_large-bowel-Myeloid_Dendritic|GI_large-bowel / Manually curated celltypes from each tissue

COL8A2 CD300LB SUCNR1 MBOAT4

1.85e-04180704400f48aa2851d89bf3b60d721bc0f635f3ad86eb
ToppCell10x5'-GI_large-bowel-Myeloid_Dendritic-DC2|GI_large-bowel / Manually curated celltypes from each tissue

COL8A2 CD300LB SUCNR1 MBOAT4

1.85e-04180704d4ebe67a2735e244c08b238320bbb441ca88ee6f
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

MACC1 DHRSX GRM5 WWC1

1.89e-041817046956ecd6264f7469a25e555673bce4eb97d28f7a
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MACC1 CFTR ROS1 WWC1

2.01e-04184704ab2f06906fc7a9931dfa0864ef506832b07fb93e
Diseaseresponse to beta blocker

POMGNT2 EMP1 GRM5

1.48e-0445673EFO_0007766
Diseasehomostachydrine measurement

EYS ERBB4

3.90e-0413672EFO_0021164
Diseaseanxiety disorder (implicated_via_orthology)

SCN3A CNR2

1.14e-0322672DOID:2030 (implicated_via_orthology)
Diseasecomplement factor H-like 1 protein measurement

FREM2 FAM43B

1.14e-0322672EFO_0600092
Diseasesmoking status measurement

FZR1 ERBB4 POMGNT2 WWP2 ENTPD6 PLCL2 PLD5 DNAJC1 GRM5

1.20e-031160679EFO_0006527
Diseasewhite matter integrity, age at assessment

WDR7 SH3PXD2A

1.59e-0326672EFO_0004641, EFO_0008007

Protein segments in the cluster

PeptideGeneStartEntry
TWTYYLQTDNGKVVV

TMEM59L

171

Q9UK28
YLYHLNVTETIQIWS

ABCA5

991

Q8WWZ7
WSGNIMTKTLLYHTY

ERV3-1

36

Q14264
KFTHQSDVWSYGVTI

ERBB4

896

Q15303
WNTYLRYITVHKSLI

CFTR

846

P13569
LSGKWLYSHVQGISY

ADAM7

291

Q9H2U9
KWIQSGHIATYYTIQ

FLG

226

P20930
ILTVGHYAVVWSIYL

DNAJC1

161

Q96KC8
LFSGIIYTYGHVLWK

CNR2

201

P34972
DHYTQIVWATSYLIG

CRISP1

141

P54107
IEGWAVVYYITHLLK

GPR107

326

Q5VW38
QIIKVYVGSHWYATT

KCTD19

396

Q17RG1
YVGSHWYATTLQTLL

KCTD19

401

Q17RG1
WLCILVGVSIYTSHY

EMP1

106

P54849
ISYVFILFTVWKHSS

OR4F21

216

O95013
VKRYNWTYVSAVHTE

GRM5

206

P41594
VNSKWLSVGTHYFIT

EYS

136

Q5T1H1
YIHILAYAASVVETW

NELFCD

356

Q8IXH7
YSHSKGQKVYLTWPV

GNPTAB

421

Q3T906
KVYYIDHTNRTTSWI

WWC1

21

Q8IX03
KHYISVYRSLAAIWI

KCNK16

226

Q96T55
AEYGVYVKVTSIQHW

HPR

326

P00739
TYTVWYLGNAVTLHA

FAM43B

71

Q6ZT52
SVWFKLYIYHVTGQG

FAM91A1

531

Q658Y4
GREWYIHTIYTVRSK

FREM2

3006

Q5SZK8
YLQNWSHVLSYVSKA

GPS1

211

Q13098
KLYAYVNSHSLFVWV

EBLN2

6

Q6P2I7
FIATSKHAYATYLWT

DSE

686

Q9UL01
KLYWTHGYVLISKEV

TUBGCP6

566

Q96RT7
HAFVGLSKITTWYQY

POMGNT2

231

Q8NAT1
SIVYYSTLLESHWTK

TMEM63A

481

O94886
STHGYSQNQILVWKY

FZR1

416

Q9UM11
YFAYHVHVKGTNVWV

COL8A2

621

P25067
GVVNTDVYKHVFWAT

DHRSX

241

Q8N5I4
VVATLYPFTWQHTYI

DENND2C

711

Q68D51
LSLNVHTWNYKETYL

C1QTNF8

166

P60827
TIWDYIHKTTSIGIY

MACC1

361

Q6ZN28
IYVVWTTAGLFKLTY

MBOAT4

241

Q96T53
TTAGLFKLTYYSHWI

MBOAT4

246

Q96T53
LRVNNGYKIWHYTGS

EIF2A

381

Q9BY44
IGYVDTTHWKVYVIA

C6orf89

316

Q6UWU4
WIHTPAKVQLSLYTY

NBEAP1

51

P0C6P0
EIWTHSYKVSNYSRG

FOLR1

191

P15328
ISYVFILFTVWKHSS

OR4F3;

216

Q6IEY1
LVKSIGNSYSYVWIG

REG3A

91

Q06141
SSIVGRLLEYVYTHW

THADA

386

Q6YHU6
SSFWIVDKQHVYIGS

PLD5

221

Q8N7P1
YVAYIKWHRATATQA

ENTPD6

56

O75354
NYVAIHTLATWYKSN

OGA

321

O60502
VHAYTSKIWNEAVSY

PUS7L

531

Q9H0K6
YHRSLISWGIINATY

SLC25A51

276

Q9H1U9
IWVTGLRYLISYGKH

PLCL2

241

Q9UPR0
FIVHKNTISYNWYAT

OR8K1

91

Q8NGG5
TLRNEHLQYIVTWYG

SURF1

266

Q15526
HLQYIVTWYGLSAAT

SURF1

271

Q15526
KLVSLRHYYFTIGWN

SCN3A

1576

Q9NY46
YHRSLISWGIINATY

SLC25A52

276

Q3SY17
VTYKWLSYTLGVHVN

POLD3

21

Q15054
ITHSLPISQWYYEAT

ALG8

46

Q9BVK2
VGITYAWFKLYVSVL

ALG8

501

Q9BVK2
SLTVQCHYKQGWETY

CD300LB

31

A8K4G0
IHWNACIYYAISKSI

CNGA2

286

Q16280
HSGFWILASIVVTYY

TMEM128

51

Q5BJH2
VYYVDHNTKTTTWER

WWP2

316

O00308
SKHYVYIINVTWSDS

SH3PXD2A

21

Q5TCZ1
ASIKHDIYSYAVITW

RIPK2

206

O43353
SHTLTYSYWTKNGVE

NPTN

176

Q9Y639
YVWRTYHLTSAGEKL

SNRNP25

91

Q9BV90
YIWSTYHDLSKFTSV

WDR44

811

Q5JSH3
LGHFLYWAGKTYVIQ

ROS1

756

P08922
NTIVVYGYIFSLKNW

SUCNR1

41

Q9BXA5
HAWKYIAYVVTGGIF

ZDHHC11

66

Q9H8X9
KVYSSSSYLAQHWRI

ZNF766

306

Q5HY98
ETIKNITHWTLFNYY

TMC2

536

Q8TDI7
HSWKYIAYVVTGGIF

ZDHHC11B

66

P0C7U3
VIIWTENGQSYIYKL

WDR7

271

Q9Y4E6