Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP17L7 USP17L4 USP17L1 USP17L3	2.05e-04	114	51	4	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP17L7 USP17L4 USP17L1 USP17L3	2.82e-04	124	51	4	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP17L7 USP17L4 USP17L1 USP17L3	4.13e-04	137	51	4	GO:0019783
GeneOntologyMolecularFunction	microtubule motor activity	KIF1A KIF1B DNAH1	7.62e-04	70	51	3	GO:0003777
GeneOntologyMolecularFunction	plus-end-directed microtubule motor activity	KIF1A KIF1B	8.49e-04	17	51	2	GO:0008574
GeneOntologyBiologicalProcess	dense core granule cytoskeletal transport	KIF1A PPFIA2 KIF1B	3.08e-06	12	51	3	GO:0099519
GeneOntologyBiologicalProcess	dense core granule transport	KIF1A PPFIA2 KIF1B	5.09e-06	14	51	3	GO:1901950
GeneOntologyBiologicalProcess	dense core granule localization	KIF1A PPFIA2 KIF1B	4.47e-05	28	51	3	GO:0032253
GeneOntologyBiologicalProcess	secretory granule localization	KIF1A PPFIA2 KIF1B	8.07e-05	34	51	3	GO:0032252
GeneOntologyBiologicalProcess	retrograde neuronal dense core vesicle transport	KIF1A KIF1B	8.93e-05	6	51	2	GO:1990049
GeneOntologyBiologicalProcess	anterograde neuronal dense core vesicle transport	KIF1A KIF1B	1.66e-04	8	51	2	GO:1990048
GeneOntologyBiologicalProcess	protein deubiquitination	USP17L7 USP17L4 USP17L1 USP17L3	2.58e-04	125	51	4	GO:0016579
Domain	UCH	USP17L7 USP17L4 USP17L1 USP17L3	3.02e-05	71	47	4	PF00443
Domain	USP_2	USP17L7 USP17L4 USP17L1 USP17L3	3.02e-05	71	47	4	PS00973
Domain	USP_3	USP17L7 USP17L4 USP17L1 USP17L3	3.19e-05	72	47	4	PS50235
Domain	USP_dom	USP17L7 USP17L4 USP17L1 USP17L3	3.19e-05	72	47	4	IPR028889
Domain	Peptidase_C19_UCH	USP17L7 USP17L4 USP17L1 USP17L3	3.19e-05	72	47	4	IPR001394
Domain	Kinesin-like_KIF1-typ	KIF1A KIF1B	3.71e-05	4	47	2	IPR022140
Domain	KIF1B	KIF1A KIF1B	3.71e-05	4	47	2	PF12423
Domain	Kinesin_assoc	KIF1A KIF1B	9.24e-05	6	47	2	PF16183
Domain	DUF3694	KIF1A KIF1B	9.24e-05	6	47	2	PF12473
Domain	Kinesin-like	KIF1A KIF1B	9.24e-05	6	47	2	IPR022164
Domain	Kinesin_assoc	KIF1A KIF1B	9.24e-05	6	47	2	IPR032405
Domain	USP_CS	USP17L7 USP17L1 USP17L3	6.12e-04	66	47	3	IPR018200
Domain	USP_1	USP17L7 USP17L4 USP17L3	7.26e-04	70	47	3	PS00972
Domain	GRAM	TBC1D9B SBF1	7.27e-04	16	47	2	SM00568
Domain	HABP4_PAI-RBP1	USP17L7 USP17L3	7.27e-04	16	47	2	PF04774
Domain	HABP4_PAIRBP1-bd	USP17L7 USP17L3	7.27e-04	16	47	2	IPR006861
Domain	HATPase_c	PDK4 MORC3	1.03e-03	19	47	2	PF02518
Domain	-	PDK4 MORC3	1.14e-03	20	47	2	3.30.565.10
Domain	HATPase_C	PDK4 MORC3	1.26e-03	21	47	2	IPR003594
Domain	GRAM	TBC1D9B SBF1	1.39e-03	22	47	2	PF02893
Domain	GRAM	TBC1D9B SBF1	1.39e-03	22	47	2	IPR004182
Domain	Ets	SPI1 ETV5	2.25e-03	28	47	2	PF00178
Domain	ETS_DOMAIN_1	SPI1 ETV5	2.25e-03	28	47	2	PS00345
Domain	ETS_DOMAIN_2	SPI1 ETV5	2.25e-03	28	47	2	PS00346
Domain	ETS	SPI1 ETV5	2.25e-03	28	47	2	SM00413
Domain	Ets_dom	SPI1 ETV5	2.25e-03	28	47	2	IPR000418
Domain	FHA	KIF1A KIF1B	2.25e-03	28	47	2	SM00240
Domain	ETS_DOMAIN_3	SPI1 ETV5	2.25e-03	28	47	2	PS50061
Domain	PH	SBF1 KIF1A KIF1B PLEKHG2	2.60e-03	229	47	4	PF00169
Domain	FHA_DOMAIN	KIF1A KIF1B	2.75e-03	31	47	2	PS50006
Domain	FHA	KIF1A KIF1B	2.75e-03	31	47	2	PF00498
Domain	FHA_dom	KIF1A KIF1B	3.70e-03	36	47	2	IPR000253
Domain	-	KIF1A KIF1B	3.70e-03	36	47	2	2.60.200.20
Domain	PH_dom-like	FRMPD4 SBF1 KIF1A KIF1B PLEKHG2	4.21e-03	426	47	5	IPR011993
Domain	Kinesin_motor_CS	KIF1A KIF1B	4.77e-03	41	47	2	IPR019821
Domain	PH	SBF1 KIF1A KIF1B PLEKHG2	5.18e-03	278	47	4	SM00233
Domain	Kinesin-like_fam	KIF1A KIF1B	5.24e-03	43	47	2	IPR027640
Domain	PH_DOMAIN	SBF1 KIF1A KIF1B PLEKHG2	5.25e-03	279	47	4	PS50003
Domain	PH_domain	SBF1 KIF1A KIF1B PLEKHG2	5.32e-03	280	47	4	IPR001849
Domain	KINESIN_MOTOR_1	KIF1A KIF1B	5.48e-03	44	47	2	PS00411
Domain	-	KIF1A KIF1B	5.48e-03	44	47	2	3.40.850.10
Domain	Kinesin_motor_dom	KIF1A KIF1B	5.48e-03	44	47	2	IPR001752
Domain	Kinesin	KIF1A KIF1B	5.48e-03	44	47	2	PF00225
Domain	KISc	KIF1A KIF1B	5.48e-03	44	47	2	SM00129
Domain	KINESIN_MOTOR_2	KIF1A KIF1B	5.48e-03	44	47	2	PS50067
Domain	SMAD_FHA_domain	KIF1A KIF1B	7.59e-03	52	47	2	IPR008984
Pathway	REACTOME_RAS_PROCESSING	USP17L7 USP17L4 USP17L1 USP17L3	7.61e-06	45	40	4	MM15671
Pubmed	High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency.	USP17L7 USP17L4 USP17L1 USP17L3	9.27e-10	10	52	4	24207026
Pubmed	Cell cycle-dependent expression of Dub3, Nanog and the p160 family of nuclear receptor coactivators (NCoAs) in mouse embryonic stem cells.	USP17L7 USP17L4 USP17L1 USP17L3	2.18e-09	12	52	4	24695638
Pubmed	ES cell neural differentiation reveals a substantial number of novel ESTs.	USP17L7 USP17L4 USP17L1 USP17L3	4.40e-09	14	52	4	11793228
Pubmed	CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1.	USP17L7 USP17L4 USP17L1 USP17L3	1.69e-08	19	52	4	28067227
Pubmed	DUB-2A, a new member of the DUB subfamily of hematopoietic deubiquitinating enzymes.	USP17L7 USP17L4 USP17L1 USP17L3	2.61e-08	21	52	4	11468161
Pubmed	The murine DUB-1 gene is specifically induced by the betac subunit of interleukin-3 receptor.	USP17L7 USP17L4 USP17L1 USP17L3	2.61e-08	21	52	4	8756639
Pubmed	DUB-1, a deubiquitinating enzyme with growth-suppressing activity.	USP17L7 USP17L4 USP17L1 USP17L3	2.61e-08	21	52	4	8622927
Pubmed	DUB-1A, a novel deubiquitinating enzyme subfamily member, is polyubiquitinated and cytokine-inducible in B-lymphocytes.	USP17L7 USP17L4 USP17L1 USP17L3	2.61e-08	21	52	4	14583620
Pubmed	Lymphocyte-specific murine deubiquitinating enzymes induced by cytokines.	USP17L7 USP17L4 USP17L1 USP17L3	2.61e-08	21	52	4	12447969
Pubmed	DUB-1, a fate determinant of dynein heavy chain in B-lymphocytes, is regulated by the ubiquitin-proteasome pathway.	USP17L7 USP17L4 USP17L1 USP17L3	2.61e-08	21	52	4	18980247
Pubmed	JAK2 is required for induction of the murine DUB-1 gene.	USP17L7 USP17L4 USP17L1 USP17L3	3.19e-08	22	52	4	9154835
Pubmed	DUB-2 is a member of a novel family of cytokine-inducible deubiquitinating enzymes.	USP17L7 USP17L4 USP17L1 USP17L3	4.62e-08	24	52	4	8995226
Pubmed	Interleukin 1 receptor signaling regulates DUBA expression and facilitates Toll-like receptor 9-driven antiinflammatory cytokine production.	USP17L7 USP17L4 USP17L1 USP17L3	5.49e-08	25	52	4	21115691
Pubmed	Decabromodiphenyl ethane affects embryonic development by interfering with nuclear F-actin in zygotes and leads to cognitive and social disorders in offspring mice.	USP17L7 USP17L4 USP17L1 USP17L3	6.48e-08	26	52	4	35816173
Pubmed	Minor Splicing Factors Zrsr1 and Zrsr2 Are Essential for Early Embryo Development and 2-Cell-Like Conversion.	USP17L7 USP17L4 USP17L1 USP17L3	1.03e-07	29	52	4	32527007
Pubmed	Cdc25A and Dub3 in a high-stakes balancing act.	USP17L7 USP17L4 USP17L1 USP17L3	1.76e-07	33	52	4	20228807
Pubmed	Polyclonal and monoclonal antibodies specific for USP17, a proapoptotic deubiquitinating enzyme.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	20715989
Pubmed	Human megasatellite DNA RS447: copy-number polymorphisms and interspecies conservation.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	9806828
Pubmed	The ubiquitin-specific protease 17 is involved in virus-triggered type I IFN signaling.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	20368735
Pubmed	The DUB/USP17 deubiquitinating enzymes, a multigene family within a tandemly repeated sequence.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	15780755
Pubmed	The DUB/USP17 deubiquitinating enzymes: a gene family within a tandemly repeated sequence, is also embedded within the copy number variable beta-defensin cluster.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	20403174
Pubmed	USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	19188362
Pubmed	Hyaluronan- and RNA-binding deubiquitinating enzymes of USP17 family members associated with cell viability.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	17109758
Pubmed	Unstable transmission of the RS447 human megasatellite tandem repetitive sequence that contains the USP17 deubiquitinating enzyme gene.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	11941478
Pubmed	The deubiquitinating enzyme USP17 is highly expressed in tumor biopsies, is cell cycle regulated, and is required for G1-S progression.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	20388806
Pubmed	DUB-3, a cytokine-inducible deubiquitinating enzyme that blocks proliferation.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	14699124
Pubmed	The RS447 human megasatellite tandem repetitive sequence encodes a novel deubiquitinating enzyme with a functional promoter.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	10936051
Pubmed	The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility.	USP17L7 USP17L4 USP17L1 USP17L3	1.99e-07	34	52	4	21448158
Pubmed	Lys-63-specific deubiquitination of SDS3 by USP17 regulates HDAC activity.	USP17L7 USP17L4 USP17L1 USP17L3	2.25e-07	35	52	4	21239494
Pubmed	Cytokine-regulated protein degradation by the ubiquitination system.	USP17L7 USP17L4 USP17L1 USP17L3	2.25e-07	35	52	4	16611142
Pubmed	The deubiquitinating enzyme USP17 blocks N-Ras membrane trafficking and activation but leaves K-Ras unaffected.	USP17L7 USP17L4 USP17L1 USP17L3	2.53e-07	36	52	4	20147298
Pubmed	Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A.	USP17L7 USP17L4 USP17L1 USP17L3	2.83e-07	37	52	4	20228808
Pubmed	DNA sequence and analysis of human chromosome 8.	USP17L7 USP17L4 USP17L1 USP17L3	8.23e-07	48	52	4	16421571
Pubmed	DUX is a non-essential synchronizer of zygotic genome activation.	USP17L7 USP17L4 USP17L1 USP17L3	9.72e-07	50	52	4	31806660
Pubmed	The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors.	KIF1A KIF1B	2.19e-06	2	52	2	7539720
Pubmed	BORC Functions Upstream of Kinesins 1 and 3 to Coordinate Regional Movement of Lysosomes along Different Microtubule Tracks.	KIF1A KIF1B	6.57e-06	3	52	2	27851960
Pubmed	In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport.	KIF1A KIF1B	6.57e-06	3	52	2	23404705
Pubmed	Human and mouse proteases: a comparative genomic approach.	USP17L7 USP17L4 USP17L1 USP17L3	6.79e-06	81	52	4	12838346
Pubmed	The Molecular Motor KIF1A Transports the TrkA Neurotrophin Receptor and Is Essential for Sensory Neuron Survival and Function.	KIF1A KIF1B	1.31e-05	4	52	2	27263974
Pubmed	KIF1Bbeta- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD.	KIF1A KIF1B	2.19e-05	5	52	2	18849981
Pubmed	Mechanosensitive brain tumor cells construct blood-tumor barrier to mask chemosensitivity.	PIEZO1 PTCH1	2.19e-05	5	52	2	36323321
Pubmed	Expansion of the renal capsular stroma, ureteric bud branching defects and cryptorchidism in mice with Wilms tumor 1 gene deletion in the stromal compartment of the developing kidney.	NPHS2 ETV5 PTCH1	2.56e-05	38	52	3	32715478
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	TEAD2 ERCC2 TBC1D9B SBF1 SEMA7A PIEZO1 PTCH1 GCN1 KIAA2013	3.44e-05	1105	52	9	35748872
Pubmed	Defects and rescue of the minor salivary glands in Eda pathway mutants.	ETV5 PTCH1	4.58e-05	7	52	2	20969842
Pubmed	HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus.	KIF1A KIF1B	6.10e-05	8	52	2	25818806
Pubmed	A dosage-dependent role for Spry2 in growth and patterning during palate development.	ETV5 PTCH1	9.79e-05	10	52	2	17693063
Pubmed	Fuz mutant mice reveal shared mechanisms between ciliopathies and FGF-related syndromes.	ETV5 PTCH1	1.20e-04	11	52	2	23806618
Pubmed	Nubp2 is required for cranial neural crest survival in the mouse.	ETV5 PTCH1	1.43e-04	12	52	2	31733190
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	KIF1A KIF1B	1.43e-04	12	52	2	16301330
Pubmed	Excess NF-κB induces ectopic odontogenesis in embryonic incisor epithelium.	ETV5 PTCH1	1.69e-04	13	52	2	25376721
Pubmed	Missing-in-metastasis MIM/MTSS1 promotes actin assembly at intercellular junctions and is required for integrity of kidney epithelia.	NPHS2 PTCH1	1.69e-04	13	52	2	21406566
Pubmed	Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb.	ETV5 PTCH1	1.97e-04	14	52	2	20826535
Pubmed	Function of PEA3 Ets transcription factors in mammary gland development and oncogenesis.	SPI1 ETV5	1.97e-04	14	52	2	14635793
Pubmed	Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis.	ETV5 PTCH1	2.60e-04	16	52	2	25053435
Pubmed	Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling.	TEAD2 ETV5	2.60e-04	16	52	2	19004856
Pubmed	The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis.	KIF1A PPFIA2 KIF1B DOLK	3.21e-04	218	52	4	33378226
Pubmed	Gata6-Dependent GLI3 Repressor Function is Essential in Anterior Limb Progenitor Cells for Proper Limb Development.	ETV5 PTCH1	3.30e-04	18	52	2	27352137
Pubmed	Tissue-specific roles of FGF signaling in external genitalia development.	ETV5 PTCH1	3.30e-04	18	52	2	25820239
Pubmed	SP8 regulates signaling centers during craniofacial development.	ETV5 PTCH1	3.69e-04	19	52	2	23872235
Pubmed	Organogenesis relies on SoxC transcription factors for the survival of neural and mesenchymal progenitors.	TEAD2 PTCH1	3.69e-04	19	52	2	20596238
Pubmed	Msx1 and Msx2 in limb mesenchyme modulate digit number and identity.	ETV5 PTCH1	4.09e-04	20	52	2	21465616
Pubmed	The transcription factor Foxg1 regulates the competence of telencephalic cells to adopt subpallial fates in mice.	ETV5 PTCH1	4.52e-04	21	52	2	20081193
Pubmed	FGF-Regulated ETV Transcription Factors Control FGF-SHH Feedback Loop in Lung Branching.	ETV5 PTCH1	4.52e-04	21	52	2	26555052
Pubmed	FGF-regulated Etv genes are essential for repressing Shh expression in mouse limb buds.	ETV5 PTCH1	4.52e-04	21	52	2	19386269
Pubmed	Multiple roles and interactions of Tbx4 and Tbx5 in development of the respiratory system.	ETV5 PTCH1	4.52e-04	21	52	2	22876201
Pubmed	FAM20B-catalyzed glycosaminoglycans control murine tooth number by restricting FGFR2b signaling.	ETV5 PTCH1	4.97e-04	22	52	2	32664967
Pubmed	Sprouty genes prevent excessive FGF signalling in multiple cell types throughout development of the cerebellum.	ETV5 PTCH1	4.97e-04	22	52	2	21693512
Pubmed	Mesodermal Tbx1 is required for patterning the proximal mandible in mice.	ETV5 PTCH1	4.97e-04	22	52	2	20501333
Pubmed	A novel role for cilia-dependent sonic hedgehog signaling during submandibular gland development.	ETV5 PTCH1	5.44e-04	23	52	2	29532549
Pubmed	Vegf regulates embryonic erythroid development through Gata1 modulation.	SPI1 PTCH1	5.93e-04	24	52	2	20554972
Pubmed	ETS-dependent regulation of a distal Gata4 cardiac enhancer.	SPI1 ETV5	5.93e-04	24	52	2	22056786
Pubmed	Fibroblast growth factor 9 signaling inhibits airway smooth muscle differentiation in mouse lung.	ETV5 PTCH1	5.93e-04	24	52	2	19097117
Pubmed	FGF/FGFR2 signaling regulates the generation and correct positioning of Bergmann glia cells in the developing mouse cerebellum.	ETV5 PTCH1	6.43e-04	25	52	2	24983448
Pubmed	T-box3 is a ciliary protein and regulates stability of the Gli3 transcription factor to control digit number.	ETV5 PTCH1	6.43e-04	25	52	2	27046536
Pubmed	A novel function of the proneural factor Ascl1 in progenitor proliferation identified by genome-wide characterization of its targets.	TEAD2 ETV5	6.43e-04	25	52	2	21536733
Pubmed	Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome.	KIF1A KIF1B	6.43e-04	25	52	2	9275178
Pubmed	Type 1 fibroblast growth factor receptor in cranial neural crest cell-derived mesenchyme is required for palatogenesis.	ETV5 PTCH1	6.96e-04	26	52	2	23754280
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	KNTC1 TBC1D9B FAM169A MORC3 KIAA2013	8.42e-04	493	52	5	15368895
Pubmed	ETS-family genes in pancreatic development.	SPI1 ETV5	8.67e-04	29	52	2	17907201
Pubmed	Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg.	SPI1 ETV5	8.67e-04	29	52	2	26097038
Pubmed	Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex.	SEMA7A PTCH1 ITM2A	9.01e-04	126	52	3	16284245
Pubmed	Suppression of epithelial differentiation by Foxi3 is essential for molar crown patterning.	ETV5 PTCH1	9.29e-04	30	52	2	26450968
Pubmed	Use of comparative physical and sequence mapping to annotate mouse chromosome 16 and human chromosome 21.	B3GALT5 MORC3	9.29e-04	30	52	2	11374901
Pubmed	Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype.	ETV5 PTCH1	9.92e-04	31	52	2	23023706
Pubmed	Wnt/β-catenin signaling maintains the mesenchymal precursor pool for murine sinus horn formation.	ETV5 PTCH1	9.92e-04	31	52	2	21757651
Pubmed	Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development.	ETV5 PTCH1	1.19e-03	34	52	2	23123965
Pubmed	Multiple roles of epithelial heparan sulfate in stomach morphogenesis.	ETV5 PTCH1	1.26e-03	35	52	2	29700203
Pubmed	Hox5 Genes Regulate the Wnt2/2b-Bmp4-Signaling Axis during Lung Development.	ETV5 PTCH1	1.34e-03	36	52	2	26235626
Pubmed	Epithelial heparan sulfate regulates Sonic Hedgehog signaling in lung development.	ETV5 PTCH1	1.34e-03	36	52	2	28859094
Pubmed	Mesenchymal FGFR1 and FGFR2 control patterning of the ureteric mesenchyme by balancing SHH and BMP4 signaling.	ETV5 PTCH1	1.41e-03	37	52	2	36094016
Pubmed	All kinesin superfamily protein, KIF, genes in mouse and human.	KIF1A KIF1B	1.41e-03	37	52	2	11416179
Cytoband	8p23.1	USP17L7 USP17L4 USP17L1 USP17L3	2.91e-05	154	52	4	8p23.1
Cytoband	Ensembl 112 genes in cytogenetic band chr8p23	USP17L7 USP17L4 USP17L1 USP17L3	1.47e-04	234	52	4	chr8p23
Cytoband	3p21.1	NT5DC2 DNAH1	1.05e-03	42	52	2	3p21.1
Cytoband	11q24.2	OR10G8 OR8G1	2.35e-03	63	52	2	11q24.2
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	SBF1 KIF1A KIF1B PLEKHG2	1.72e-04	206	25	4	682
GeneFamily	ETS transcription factor family	SPI1 ETV5	6.79e-04	28	25	2	534
GeneFamily	Kinesins\|Pleckstrin homology domain containing	KIF1A KIF1B	1.83e-03	46	25	2	622
GeneFamily	Olfactory receptors, family 10	OR10G2 OR10G8	3.73e-03	66	25	2	157
ToppCell	renal_papilla_nuclei\|World / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9C1 LINGO1 PDK4 FAM169A B3GALT5	1.96e-06	180	51	5	49829e833fe6d2431cfd2e8f378c2aaa3b2b46a4
ToppCell	droplet-Kidney-KIDNEY-30m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FRMPD4 KIF1A FAM169A CCDC171 LRRD1	2.02e-06	181	51	5	7af469f5bcb9b1ab3f35b2758bf2afb87e8eba57
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid-Microglia\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SPI1 PDK4 PIEZO1 SUCNR1 PIK3R5	3.13e-06	198	51	5	901cd39cb84f1907f2f5d27221979c854bd3b40e
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW16-Myeloid\|GW16 / Sample Type, Dataset, Time_group, and Cell type.	SPI1 PDK4 PIEZO1 SUCNR1 PIK3R5	3.13e-06	198	51	5	cc292aa8518d5ef8940e2327f2f07d584a996d90
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	KNTC1 ZNF487 KIF1B DNAH1	4.18e-05	169	51	4	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|metastatic_Lymph_Node / Location, Cell class and cell subclass	KNTC1 PDK4 KIF1B DNAH1	4.48e-05	172	51	4	f673a2e697b46e7cfa4186cb3fb2b98e3c83703e
ToppCell	368C-Myeloid-Dendritic-cDC_proliferating_1\|368C / Donor, Lineage, Cell class and subclass (all cells)	ETV5 SUCNR1 CCDC171 GCN1	5.23e-05	179	51	4	ec69e1dd897414033ba5b007aa82655a79adca6c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	USP17L1 PPFIA2 ETV5 SUCNR1	5.46e-05	181	51	4	22363c5835dd6cef8f895ab9362e0837d92b15b1
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PDK4 PPFIA2 ETV5 SUCNR1	5.95e-05	185	51	4	74b787e225d83efcb84e79c23499febe1a106622
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SPI1 ETV5 SUCNR1 PIK3R5	6.33e-05	188	51	4	0d7296ad26e97ad91c6927a6cfe4e6e70a74c5a6
ToppCell	(3)_Chondrocytes-(31)_Chondro-hyper\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	LINGO1 NT5DC2 FAM180A PTCH1	6.46e-05	189	51	4	394b153393904c3dba51a6bfe338afd554e66649
ToppCell	3'-Adult-LargeIntestine-Hematopoietic-Myeloid-Macrophages\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SPI1 ETV5 SUCNR1 PIK3R5	6.46e-05	189	51	4	b491204cf38dc80a2583e3082a82dda8d77b3fc4
ToppCell	(1)_Osterolineage_cells-(10)_OLC-1\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	SEMA7A PDK4 NT5DC2 PPFIA2	6.46e-05	189	51	4	46c5b975fb9d33017f2d9b7770d45a8bdf95baa2
ToppCell	(3)_Chondrocytes\|World / Cell class and subclass of bone marrow stroma cells in homeostatis	LINGO1 FAM180A PTCH1 ITM2A	6.87e-05	192	51	4	5d2b4830d025d3dbdf5623ce1c28d1036e1984a8
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9C1 PDK4 PIEZO1 B3GALT5	7.15e-05	194	51	4	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SLC9C1 PDK4 PIEZO1 B3GALT5	7.15e-05	194	51	4	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	(7)_MNP-(7)_Macrophage\|(7)_MNP / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PDK4 ETV5 SUCNR1 ITM2A	7.44e-05	196	51	4	71ec157163278ad259c190051926bf41e4ecef46
ToppCell	mLN-Macrophage-Macrophage\|mLN / Region, Cell class and subclass	SPI1 PDK4 ETV5 SUCNR1	7.89e-05	199	51	4	6bbec8450afb30347b07da28401a698fc51a3c53
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac-Erythrophagocytic_macrophages\|lymph-node_spleen / Manually curated celltypes from each tissue	SPI1 PDK4 ETV5 SUCNR1	7.89e-05	199	51	4	78db2e3b85356ed2f08794e5a97c16a220f8a076
ToppCell	10x5'-Liver-Myeloid_Mac-Erythrophagocytic_macrophages\|Liver / Manually curated celltypes from each tissue	SPI1 PDK4 ETV5 SUCNR1	7.89e-05	199	51	4	600afac424416268766fc5c051d4c62ab9eef5de
ToppCell	mLN-(6)_Macrophage-(60)_Macrophage\|mLN / shred on region, Cell_type, and subtype	SPI1 PDK4 ETV5 SUCNR1	7.89e-05	199	51	4	1ea28b832c6173b1b58da432aaf21e6cd291561e
ToppCell	10x5'-Liver-Myeloid_Mac\|Liver / Manually curated celltypes from each tissue	SPI1 PDK4 ETV5 SUCNR1	7.89e-05	199	51	4	aed138ee879e4e625f177c5bfe0f857a335eb6f2
ToppCell	10x5'-lymph-node_spleen-Myeloid_Mac\|lymph-node_spleen / Manually curated celltypes from each tissue	SPI1 PDK4 ETV5 SUCNR1	7.89e-05	199	51	4	c051cc3e42cfa2ec09fd8dae1172af350bb2dfcb
Drug	Methoxy-6-harmalan [3589-73-9]; Up 200; 18.6uM; PC3; HT_HG-U133A	SPAM1 KIF1A PDK4 ETV5 PTCH1 AKAP1	2.89e-06	199	46	6	6355_UP
Disease	primary ovarian insufficiency (implicated_via_orthology)	USP17L7 USP17L4 USP17L1 USP17L3	7.35e-07	46	45	4	DOID:5426 (implicated_via_orthology)
Disease	congenital heart disease (implicated_via_orthology)	USP17L7 USP17L4 USP17L1 USP17L3	3.79e-06	69	45	4	DOID:1682 (implicated_via_orthology)
Disease	synucleinopathy (biomarker_via_orthology)	KIF1A KIF1B	1.36e-05	4	45	2	DOID:0050890 (biomarker_via_orthology)
Disease	hereditary spastic paraplegia (is_implicated_in)	KIF1A BSCL2	4.75e-05	7	45	2	DOID:2476 (is_implicated_in)
Disease	ovary epithelial cancer (is_implicated_in)	ERCC2 KIF1B	1.24e-04	11	45	2	DOID:2152 (is_implicated_in)
Disease	Basal cell carcinoma	ERCC2 PTCH1	1.24e-04	11	45	2	C0007117
Disease	nervous system disease (implicated_via_orthology)	KIF1A KIF1B	1.49e-04	12	45	2	DOID:863 (implicated_via_orthology)
Disease	kidney volume	PTCH1 CCDC171	3.43e-04	18	45	2	EFO_0600044
Disease	smoking behavior, BMI-adjusted waist circumference	NT5DC2 KIF1B PTCH1	8.62e-04	122	45	3	EFO_0004318, EFO_0007789

Protein segments in the cluster

Peptide	Gene	Start	Entry
LRSLDQQMYLCYSQP	AKAP1	736	Q92667
CALMAGALYPLYSRS	CCDC171	731	Q6TFL3
LGALCLYFSMYSLNP	B3GALT5	16	Q9Y2C3
YAMCLPNLTRLQTYR	IPPK	111	Q9H8X2
SRMLCDQYYLSSPEL	PDK4	211	Q16654
DRYMAICSPLLYSVI	OR8G1	121	Q15617
IMYFPLGLCALDSLY	LRRD1	476	A4D1F6
YLNMILLYLLPRCFT	DOLK	176	Q9UPQ8
CYYALLASLSVMSPN	HSFX4	311	A0A1B0GTS1
NLNEDPLMSECLLYY	KIF1B	536	O60333
LRAYCSILYLKPRMQ	MORC3	251	Q14149
YLNCERYSIGLLDMT	PDE6C	271	P51160
NYTLRVDCTPLMYSL	FOLH1B	151	Q9HBA9
AICYYRMENASLLLS	NPHS2	191	Q9NP85
SLLALIMAYQRAYPL	ERCC2	51	P18074
YLLLSRPIDYSSRML	KNTC1	1851	P50748
YLDTMTPNCLYGLNL	LINGO1	251	Q96FE5
AYLLDMDRCSSLPYA	ETV5	491	P41161
YLQCMLASYRGDTLL	GCN1	446	Q92616
VMSCDRYLAISYPLR	OR10G8	116	Q8NGN5
EDLPYLSTTEMYLCR	MSL1	421	Q68DK7
CYYALLASLSVMSPN	HSFX3	311	A0A1B0GWH4
YANRMSYLLLPLDSS	SBF1	761	O95248
EALLLYNLYVDCMPS	DNAH1	386	Q9P2D7
LCYNAALTYMPSVSL	FAM126A	186	Q9BYI3
AMNLACLTAGYYRLL	FRMPD4	501	Q14CM0
LGLRYPLSSLMYTAC	FAM169A	211	Q9Y6X4
AYLDLLLGNCYLMPL	ITM2A	151	O43736
LLLLLLYYNAEASMC	FAM180A	6	Q6UWF9
CLLLDNYMETILNPY	SPAM1	351	P38567
TGLRYLLYNFPMTCA	BSCL2	221	Q96G97
NLNEDPLMSECLLYY	KIF1A	496	Q12756
SLGLPQYRSYFMECL	PPFIA2	1031	O75334
TLMAYDRYLAICQPL	OR10G2	121	Q8NGC3
PNINMALLLAYSDLY	SLC9C1	376	Q4G0N8
RVASGYLLMLAYACL	PTCH1	441	Q13635
VYRLLRSPMCEYLVN	TEAD2	371	Q15562
TQYTCMLLRYLLEPK	PEX11A	21	O75192
VSYLPRMCLQYPSLS	SPI1	111	P17947
LVALCERMLPDYYNT	TBC1D9B	616	Q66K14
QCLTYTLPLANYMLS	USP17L3	96	A6NCW0
QCLTYTLPLANYMLS	USP17L4	96	A6NCW7
QLPILADMLLYYCRF	PIK3R5	651	Q8WYR1
CYIMYLTFSALSSRP	SERINC4	296	A6NH21
LAPNSRYYLSCPMES	SEMA7A	556	O75326
QCLTYTLPLANYMLS	USP17L1	96	Q7RTZ2
SDLYMASLSCLLNYR	NT5DC2	466	Q9H857
PNYNLIYSMCLTLLG	SUCNR1	181	Q9BXA5
QCLTYTLPLSNYMLS	USP17L7	96	P0C7H9
LYCMNYPSSLALLRE	PLEKHG2	191	Q9H7P9
YPCLDLGAMLLYTLT	PIEZO1	511	Q92508
MLENYSLLLSVGYCI	ZNF487	66	B1APH4
TVNLTLYYMLSCSPA	KIAA2013	361	Q8IYS2