Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serine-type endopeptidase inhibitor activity	SPINT3 APLP2 APP WFIKKN2 SPINK5	1.21e-06	105	36	5	GO:0004867
GeneOntologyMolecularFunction	endopeptidase inhibitor activity	SPINT3 APLP2 APP WFIKKN2 SPINK5	1.69e-05	180	36	5	GO:0004866
GeneOntologyMolecularFunction	peptidase inhibitor activity	SPINT3 APLP2 APP WFIKKN2 SPINK5	2.03e-05	187	36	5	GO:0030414
GeneOntologyMolecularFunction	endopeptidase regulator activity	SPINT3 APLP2 APP WFIKKN2 SPINK5	2.88e-05	201	36	5	GO:0061135
GeneOntologyMolecularFunction	peptidase regulator activity	SPINT3 APLP2 APP WFIKKN2 SPINK5	9.24e-05	257	36	5	GO:0061134
GeneOntologyMolecularFunction	enzyme inhibitor activity	SPINT3 PRKAR2B APLP2 APP WFIKKN2 SPINK5	1.16e-04	435	36	6	GO:0004857
GeneOntologyMolecularFunction	integrin binding	ITGA8 VWF APP ADAM9	2.70e-04	175	36	4	GO:0005178
GeneOntologyMolecularFunction	collagen binding	NID1 VWF ADAM9	4.17e-04	81	36	3	GO:0005518
GeneOntologyMolecularFunction	molecular function inhibitor activity	SPINT3 PRKAR2B APLP2 APP WFIKKN2 SPINK5	6.26e-04	596	36	6	GO:0140678
GeneOntologyMolecularFunction	enzyme regulator activity	SPINT3 OBSCN PRKAR2B APLP2 RCC1 HERC1 APP WFIKKN2 SPINK5	7.30e-04	1418	36	9	GO:0030234
GeneOntologyMolecularFunction	laminin binding	NID1 ADAM9	1.71e-03	34	36	2	GO:0043236
GeneOntologyCellularComponent	cell surface	ITGA8 CD93 FCRL4 GPC2 FCRL3 VWF APP ENPP3 ADAM9	8.38e-05	1111	36	9	GO:0009986
GeneOntologyCellularComponent	external side of plasma membrane	ITGA8 FCRL4 FCRL3 VWF ENPP3 ADAM9	2.35e-04	519	36	6	GO:0009897
GeneOntologyCellularComponent	platelet alpha granule	APLP2 VWF APP	5.47e-04	93	36	3	GO:0031091
GeneOntologyCellularComponent	side of membrane	ITGA8 FCRL4 GPC2 FCRL3 VWF ENPP3 ADAM9	6.33e-04	875	36	7	GO:0098552
GeneOntologyCellularComponent	dendritic spine	ITGA8 PRKAR2B APLP2 APP	7.71e-04	242	36	4	GO:0043197
GeneOntologyCellularComponent	neuron spine	ITGA8 PRKAR2B APLP2 APP	8.33e-04	247	36	4	GO:0044309
MousePheno	decreased T helper 1 cell number	ZRANB1 SLC1A5	4.74e-05	5	31	2	MP:0008087
MousePheno	decreased T-helper 17 cell number	ZRANB1 SLC1A5	9.93e-05	7	31	2	MP:0010220
Domain	-	SPINT3 APLP2 APP WFIKKN2	3.91e-08	18	37	4	4.10.410.10
Domain	Prtase_inh_Kunz-CS	SPINT3 APLP2 APP WFIKKN2	3.91e-08	18	37	4	IPR020901
Domain	KU	SPINT3 APLP2 APP WFIKKN2	3.91e-08	18	37	4	SM00131
Domain	BPTI_KUNITZ_2	SPINT3 APLP2 APP WFIKKN2	4.94e-08	19	37	4	PS50279
Domain	Kunitz_BPTI	SPINT3 APLP2 APP WFIKKN2	4.94e-08	19	37	4	PF00014
Domain	BPTI_KUNITZ_1	SPINT3 APLP2 APP WFIKKN2	4.94e-08	19	37	4	PS00280
Domain	Kunitz_BPTI	SPINT3 APLP2 APP WFIKKN2	1.12e-07	23	37	4	IPR002223
Domain	Amyloid_glyco_E2_domain	APLP2 APP	1.14e-05	3	37	2	IPR024329
Domain	A4_EXTRA	APLP2 APP	1.14e-05	3	37	2	PS00319
Domain	Amyloid_glyco_heparin-bd	APLP2 APP	1.14e-05	3	37	2	IPR015849
Domain	APP_Cu_bd	APLP2 APP	1.14e-05	3	37	2	PF12924
Domain	APP_E2	APLP2 APP	1.14e-05	3	37	2	PF12925
Domain	APP_amyloid	APLP2 APP	1.14e-05	3	37	2	PF10515
Domain	A4_INTRA	APLP2 APP	1.14e-05	3	37	2	PS00320
Domain	Amyloid_glyco	APLP2 APP	1.14e-05	3	37	2	IPR008155
Domain	Amyloid_glyco_extra	APLP2 APP	1.14e-05	3	37	2	IPR008154
Domain	-	APLP2 APP	1.14e-05	3	37	2	3.90.570.10
Domain	-	APLP2 APP	1.14e-05	3	37	2	3.30.1490.140
Domain	APP_amyloid_C	APLP2 APP	1.14e-05	3	37	2	IPR019543
Domain	Amyloid_glyco_extracell_CS	APLP2 APP	1.14e-05	3	37	2	IPR019744
Domain	Amyloid_glyco_intracell_CS	APLP2 APP	1.14e-05	3	37	2	IPR019745
Domain	Amyloid_glyco_Cu-bd	APLP2 APP	1.14e-05	3	37	2	IPR011178
Domain	APP_N	APLP2 APP	1.14e-05	3	37	2	PF02177
Domain	A4_EXTRA	APLP2 APP	1.14e-05	3	37	2	SM00006
Domain	cEGF	CD93 NID1 FBN3	1.80e-05	26	37	3	IPR026823
Domain	cEGF	CD93 NID1 FBN3	1.80e-05	26	37	3	PF12662
Domain	KAZAL_1	WFIKKN2 SPINK5	5.73e-04	18	37	2	PS00282
Domain	EGF_CA	CD93 NID1 FBN3	6.54e-04	86	37	3	PF07645
Domain	RCC1	RCC1 HERC1	7.09e-04	20	37	2	PF00415
Domain	RCC1_1	RCC1 HERC1	7.83e-04	21	37	2	PS00625
Domain	RCC1_2	RCC1 HERC1	7.83e-04	21	37	2	PS00626
Domain	RCC1_3	RCC1 HERC1	7.83e-04	21	37	2	PS50012
Domain	Reg_chr_condens	RCC1 HERC1	8.60e-04	22	37	2	IPR000408
Domain	-	RCC1 HERC1	8.60e-04	22	37	2	2.130.10.30
Domain	EGF_Ca-bd_CS	CD93 NID1 FBN3	9.28e-04	97	37	3	IPR018097
Domain	RCC1/BLIP-II	RCC1 HERC1	9.41e-04	23	37	2	IPR009091
Domain	EGF_CA	CD93 NID1 FBN3	9.85e-04	99	37	3	PS01187
Domain	ASX_HYDROXYL	CD93 NID1 FBN3	1.01e-03	100	37	3	PS00010
Domain	IGc2	OBSCN FCRL4 FCRL3 WFIKKN2	1.16e-03	235	37	4	SM00408
Domain	EGF_3	CD93 NID1 ADAM9 FBN3	1.16e-03	235	37	4	PS50026
Domain	Ig_sub2	OBSCN FCRL4 FCRL3 WFIKKN2	1.16e-03	235	37	4	IPR003598
Domain	EGF	CD93 NID1 ADAM9 FBN3	1.16e-03	235	37	4	SM00181
Domain	EGF-type_Asp/Asn_hydroxyl_site	CD93 NID1 FBN3	1.20e-03	106	37	3	IPR000152
Domain	EGF-like_dom	CD93 NID1 ADAM9 FBN3	1.44e-03	249	37	4	IPR000742
Domain	EGF-like_CS	CD93 NID1 ADAM9 FBN3	1.71e-03	261	37	4	IPR013032
Domain	EGF_CA	CD93 NID1 FBN3	1.80e-03	122	37	3	SM00179
Domain	EGF_2	CD93 NID1 ADAM9 FBN3	1.81e-03	265	37	4	PS01186
Domain	EGF-like_Ca-bd_dom	CD93 NID1 FBN3	1.88e-03	124	37	3	IPR001881
Domain	EGF	CD93 NID1 FBN3	1.97e-03	126	37	3	PF00008
Domain	Kazal_2	WFIKKN2 SPINK5	2.31e-03	36	37	2	PF07648
Domain	Growth_fac_rcpt_	CD93 NID1 FBN3	3.61e-03	156	37	3	IPR009030
Domain	KAZAL	WFIKKN2 SPINK5	3.74e-03	46	37	2	SM00280
Domain	KAZAL_2	WFIKKN2 SPINK5	4.41e-03	50	37	2	PS51465
Domain	Kazal_dom	WFIKKN2 SPINK5	4.58e-03	51	37	2	IPR002350
Pathway	REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION	ITGA8 NID1 VWF APP ADAM9 FBN3	2.78e-05	300	29	6	M610
Pathway	BIOCARTA_AKAP95_PATHWAY	PRKAR2B AKAP8	1.82e-04	10	29	2	MM1344
Pathway	BIOCARTA_AKAP95_PATHWAY	PRKAR2B AKAP8	2.22e-04	11	29	2	M5731
Pubmed	Amyloid precursor family proteins are expressed by thymic and lymph node stromal cells but are not required for lymphocyte development.	APLP2 APP	1.10e-06	2	37	2	19710207
Pubmed	beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.	APLP2 APP	1.10e-06	2	37	2	7758106
Pubmed	Identification of the Alzheimer's disease amyloid precursor protein (APP) and its homologue APLP2 as essential modulators of glucose and insulin homeostasis and growth.	APLP2 APP	1.10e-06	2	37	2	18393365
Pubmed	The amyloid precursor protein and its homologues: structural and functional aspects of native and pathogenic oligomerization.	APLP2 APP	1.10e-06	2	37	2	21459473
Pubmed	Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex.	APLP2 APP	1.10e-06	2	37	2	21435241
Pubmed	Interaction of human and mouse Abeta peptides.	APLP2 APP	1.10e-06	2	37	2	15584916
Pubmed	Amyloid precursor protein trafficking, processing, and function.	APLP2 APP	1.10e-06	2	37	2	18650430
Pubmed	Keratinocytes from APP/APLP2-deficient mice are impaired in proliferation, adhesion and migration in vitro.	APLP2 APP	1.10e-06	2	37	2	16584729
Pubmed	AbetaPP/APLP2 family of Kunitz serine proteinase inhibitors regulate cerebral thrombosis.	APLP2 APP	1.10e-06	2	37	2	19403832
Pubmed	A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.	APLP2 APP	1.10e-06	2	37	2	21266574
Pubmed	Embryonic stem cell-derived neurons as a cellular system to study gene function: lack of amyloid precursor proteins APP and APLP2 leads to defective synaptic transmission.	APLP2 APP	1.10e-06	2	37	2	18535156
Pubmed	Differential distribution of Alzheimer's amyloid precursor protein family variants in human sperm.	APLP2 APP	1.10e-06	2	37	2	17405931
Pubmed	Combined deletions of amyloid precursor protein and amyloid precursor-like protein 2 reveal different effects on mouse brain metal homeostasis.	APLP2 APP	1.10e-06	2	37	2	24448592
Pubmed	The APP Intracellular Domain Is Required for Normal Synaptic Morphology, Synaptic Plasticity, and Hippocampus-Dependent Behavior.	APLP2 APP	1.10e-06	2	37	2	26658856
Pubmed	Hippocampal network oscillations in APP/APLP2-deficient mice.	APLP2 APP	1.10e-06	2	37	2	23585881
Pubmed	Generation of conditional null alleles for APP and APLP2.	APLP2 APP	1.10e-06	2	37	2	20140888
Pubmed	Quantitation and localization of intracellular redox active metals by X-ray fluorescence microscopy in cortical neurons derived from APP and APLP2 knockout tissue.	APLP2 APP	1.10e-06	2	37	2	25098278
Pubmed	Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.	APLP2 APP	1.10e-06	2	37	2	9461064
Pubmed	Amyloid precursor protein and amyloid precursor-like protein 2 have distinct roles in modulating myelination, demyelination, and remyelination of axons.	APLP2 APP	1.10e-06	2	37	2	30506868
Pubmed	Copper levels are increased in the cerebral cortex and liver of APP and APLP2 knockout mice.	APLP2 APP	1.10e-06	2	37	2	10526140
Pubmed	APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP.	APLP2 APP	1.10e-06	2	37	2	21522131
Pubmed	Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.	APLP2 APP	1.10e-06	2	37	2	15919150
Pubmed	Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cellular copper levels in primary mouse cortical neurons and embryonic fibroblasts.	APLP2 APP	1.10e-06	2	37	2	15447675
Pubmed	APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses.	APLP2 APP	1.10e-06	2	37	2	26551565
Pubmed	Identification of a novel amyloid precursor protein processing pathway that generates secreted N-terminal fragments.	APLP2 APP	1.10e-06	2	37	2	22490781
Pubmed	Lack of APP and APLP2 in GABAergic Forebrain Neurons Impairs Synaptic Plasticity and Cognition.	APLP2 APP	1.10e-06	2	37	2	32219307
Pubmed	A secreted form of human ADAM9 has an alpha-secretase activity for APP.	APP ADAM9	1.10e-06	2	37	2	12054541
Pubmed	Entactin-induced inhibition of human amyloid beta-protein fibril formation in vitro.	NID1 APP	1.10e-06	2	37	2	11376898
Pubmed	Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2.	APLP2 APP	1.10e-06	2	37	2	15689559
Pubmed	Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.	APLP2 APP	3.30e-06	3	37	2	11050115
Pubmed	Acute function of secreted amyloid precursor protein fragment APPsα in synaptic plasticity.	APLP2 APP	3.30e-06	3	37	2	25432317
Pubmed	Genetic dissection of the amyloid precursor protein in developmental function and amyloid pathogenesis.	APLP2 APP	3.30e-06	3	37	2	20693289
Pubmed	Differential role of APP and APLPs for neuromuscular synaptic morphology and function.	APLP2 APP	3.30e-06	3	37	2	24998676
Pubmed	Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.	APLP2 APP	3.30e-06	3	37	2	29018038
Pubmed	Regulation of gene expression by the APP family in the adult cerebral cortex.	APLP2 APP	3.30e-06	3	37	2	34997052
Pubmed	MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2.	APLP2 APP	3.30e-06	3	37	2	22510281
Pubmed	The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.	APLP2 APP	3.30e-06	3	37	2	21445342
Pubmed	Amyloid precursor proteins are constituents of the presynaptic active zone.	APLP2 APP	3.30e-06	3	37	2	23815291
Pubmed	ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.	APP ADAM9	3.30e-06	3	37	2	21956108
Pubmed	Gene silencing analyses against amyloid precursor protein (APP) gene family by RNA interference.	APLP2 APP	3.30e-06	3	37	2	16889988
Pubmed	APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival.	APLP2 APP	3.30e-06	3	37	2	32891188
Pubmed	Subcellular localization and dimerization of APLP1 are strikingly different from APP and APLP2.	APLP2 APP	3.30e-06	3	37	2	19126676
Pubmed	APLP2 regulates neuronal stem cell differentiation during cortical development.	APLP2 APP	3.30e-06	3	37	2	23345401
Pubmed	Lengthening of G2/mitosis in cortical precursors from mice lacking beta-amyloid precursor protein.	APLP2 APP	3.30e-06	3	37	2	15561424
Pubmed	Distinct in vivo roles of secreted APP ectodomain variants APPsα and APPsβ in regulation of spine density, synaptic plasticity, and cognition.	APLP2 APP	3.30e-06	3	37	2	29661886
Pubmed	Amyloid precursor protein (APP)/APP-like protein 2 (APLP2) expression is required to initiate endosome-nucleus-autophagosome trafficking of glypican-1-derived heparan sulfate.	APLP2 APP	3.30e-06	3	37	2	24898256
Pubmed	APPsα rescues impaired Ca2+ homeostasis in APP- and APLP2-deficient hippocampal neurons.	APLP2 APP	3.30e-06	3	37	2	34172567
Pubmed	The amyloid precursor protein (APP) of Alzheimer disease and its paralog, APLP2, modulate the Cu/Zn-Nitric Oxide-catalyzed degradation of glypican-1 heparan sulfate in vivo.	APLP2 APP	3.30e-06	3	37	2	15677459
Pubmed	Homo- and heterodimerization of APP family members promotes intercellular adhesion.	APLP2 APP	3.30e-06	3	37	2	16193067
Pubmed	Binding of F-spondin to amyloid-beta precursor protein: a candidate amyloid-beta precursor protein ligand that modulates amyloid-beta precursor protein cleavage.	APLP2 APP	6.60e-06	4	37	2	14983046
Pubmed	First identification of ITM2B interactome in the human retina.	APLP2 APP	6.60e-06	4	37	2	34446781
Pubmed	APP, APLP2 and LRP1 interact with PCSK9 but are not required for PCSK9-mediated degradation of the LDLR in vivo.	APLP2 APP	6.60e-06	4	37	2	28495363
Pubmed	Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.	APLP2 APP	6.60e-06	4	37	2	15208260
Pubmed	Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.	APLP2 APP	6.60e-06	4	37	2	8855266
Pubmed	cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.	APLP2 APP	6.60e-06	4	37	2	8894693
Pubmed	Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression.	APLP2 APP	6.60e-06	4	37	2	17556541
Pubmed	Amyloid precursor proteins anchor CPEB to membranes and promote polyadenylation-induced translation.	APLP2 APP	6.60e-06	4	37	2	16314516
Pubmed	Loss of all three APP family members during development impairs synaptic function and plasticity, disrupts learning, and causes an autism-like phenotype.	APLP2 APP	6.60e-06	4	37	2	34008862
Pubmed	Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APP.	APLP2 APP	6.60e-06	4	37	2	20855613
Pubmed	Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein.	APLP2 APP	6.60e-06	4	37	2	9461550
Pubmed	Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1.	APLP2 APP	6.60e-06	4	37	2	10460257
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RBM14 CEP350 RCC1 AGPS AKAP8 APP SLC1A5 SUPT16H	9.93e-06	1024	37	8	24711643
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	RBM14 CEP350 RCC1 TXLNA AGPS AKAP8 SLC1A5 PPP1CB SUPT16H	1.03e-05	1371	37	9	36244648
Pubmed	FGF11 induced by hypoxia interacts with HIF-1α and enhances its stability.	RBM14 HERC1 AKAP8 PPP1CB	1.05e-05	128	37	4	28027390
Pubmed	Fc receptor-like 1-5 molecules are similarly expressed in progressive and indolent clinical subtypes of B-cell chronic lymphocytic leukemia.	FCRL4 FCRL3	1.10e-05	5	37	2	18704934
Pubmed	Amyolid precursor protein mediates presynaptic localization and activity of the high-affinity choline transporter.	APLP2 APP	1.10e-05	5	37	2	17709753
Pubmed	Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein.	APLP2 APP	1.10e-05	5	37	2	10081969
Pubmed	Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1.	APLP2 APP	1.10e-05	5	37	2	12917434
Pubmed	Identification of a family of Fc receptor homologs with preferential B cell expression.	FCRL4 FCRL3	1.10e-05	5	37	2	11493702
Pubmed	APLP1 Is a Synaptic Cell Adhesion Molecule, Supporting Maintenance of Dendritic Spines and Basal Synaptic Transmission.	APLP2 APP	1.10e-05	5	37	2	28450540
Pubmed	Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia.	FCRL4 FCRL3	1.10e-05	5	37	2	16849395
Pubmed	Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling.	APLP2 APP	1.10e-05	5	37	2	21293490
Pubmed	IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells.	FCRL4 FCRL3	1.10e-05	5	37	2	11929751
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	CEP350 APLP2 RCC1 HERC1 APP SLC1A5 PPP1CB SUPT16H	1.18e-05	1049	37	8	27880917
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	RBM14 APLP2 RCC1 GPC2 AGPS AKAP8 PPP1CB SUPT16H	1.48e-05	1082	37	8	38697112
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	CEP350 PRKAR2B AGPS AKAP8 ADAM9	1.55e-05	298	37	5	32353859
Pubmed	The Amyloid Precursor Protein Is a Conserved Receptor for Slit to Mediate Axon Guidance.	APLP2 APP	1.65e-05	6	37	2	28785723
Pubmed	Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1.	APLP2 APP	1.65e-05	6	37	2	14699153
Pubmed	Presynaptic and postsynaptic interaction of the amyloid precursor protein promotes peripheral and central synaptogenesis.	APLP2 APP	1.65e-05	6	37	2	19726636
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	ITGA8 NID1 RCC1 TXLNA SLC1A5	1.79e-05	307	37	5	37499664
Pubmed	Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.	OBSCN TXLNA HERC1 SUPT16H	1.91e-05	149	37	4	25184681
Pubmed	Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes.	SCRN1 APLP2 APP	1.97e-05	49	37	3	19019082
Pubmed	Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein.	APLP2 APP	2.30e-05	7	37	2	7542371
Pubmed	Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.	APLP2 APP	2.30e-05	7	37	2	15385965
Pubmed	Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.	APLP2 APP	2.30e-05	7	37	2	19005074
Pubmed	Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1.	APLP2 APP	2.30e-05	7	37	2	17920016
Pubmed	Topoisomerase II regulates the maintenance of DNA methylation.	RCC1 SUPT16H	2.30e-05	7	37	2	25451918
Pubmed	Preferential expression of connexin37 and connexin40 in the endothelium of the portal veins during mouse liver development.	NID1 VWF	3.07e-05	8	37	2	16505993
Pubmed	Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP.	APLP2 APP	3.07e-05	8	37	2	15944124
Pubmed	The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation.	RBM14 RCC1 SLC1A5 ADAM9 PPP1CB SUPT16H	3.94e-05	604	37	6	37616343
Pubmed	APP interacts with LRP4 and agrin to coordinate the development of the neuromuscular junction in mice.	APLP2 APP	3.95e-05	9	37	2	23986861
Pubmed	Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.	APLP2 APP	3.95e-05	9	37	2	11247302
Pubmed	Essential roles for the FE65 amyloid precursor protein-interacting proteins in brain development.	APLP2 APP	4.93e-05	10	37	2	16407979
Pubmed	Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans.	CD93 APP	4.93e-05	10	37	2	9136074
Pubmed	Acetylation of ELF5 suppresses breast cancer progression by promoting its degradation and targeting CCND1.	RBM14 RCC1 TXLNA AGPS AKAP8 SLC1A5	6.06e-05	653	37	6	33742100
Pubmed	Oct4 links multiple epigenetic pathways to the pluripotency network.	APLP2 AKAP8 PPP1CB SUPT16H	6.40e-05	203	37	4	22083510
Pubmed	Phosphorylation of BACH1 switches its function from transcription factor to mitotic chromosome regulator and promotes its interaction with HMMR.	RCC1 PPP1CB SUPT16H	7.10e-05	75	37	3	29459360
Pubmed	The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL.	FCRL4 FCRL3	7.22e-05	12	37	2	17273841
Pubmed	PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.	PRKAR2B PPP1CB	7.22e-05	12	37	2	10830164
Pubmed	Engagement of the G3BP2-TRIM25 Interaction by Nucleocapsid Protein Suppresses the Type I Interferon Response in SARS-CoV-2-Infected Cells.	RBM14 SLC1A5 FBN3	7.39e-05	76	37	3	36560452
Interaction	DECR2 interactions	ITGA8 AGPS APP ZRANB1	2.54e-06	54	36	4	int:DECR2
Interaction	ATAT1 interactions	HERC1 APP ZRANB1	7.88e-06	22	36	3	int:ATAT1
Interaction	RSPH10B2 interactions	HERC1 APP	1.86e-05	4	36	2	int:RSPH10B2
Interaction	COL4A3 interactions	CD93 NID1 APP	2.06e-05	30	36	3	int:COL4A3
Interaction	PRDM16 interactions	RBM14 TXLNA AKAP8 PPP1CB SUPT16H	2.38e-05	195	36	5	int:PRDM16
Interaction	ATG16L1 interactions	RBM14 CEP350 RCC1 TXLNA AGPS HERC1 APP ZRANB1 PPP1CB SUPT16H	2.48e-05	1161	36	10	int:ATG16L1
Interaction	PRKAR2A interactions	PRKAR2B AKAP8 APP ZRANB1 PPP1CB	3.97e-05	217	36	5	int:PRKAR2A
Interaction	ADH4 interactions	APP ZRANB1	4.63e-05	6	36	2	int:ADH4
Interaction	DCAF4 interactions	RBM14 CEP350 AKAP8 ZRANB1 SPINK5 SUPT16H	5.06e-05	378	36	6	int:DCAF4
ToppCell	facs-Brain_Myeloid-Striatum-24m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 PRKAR2B APEX2 SLC1A5	1.38e-05	177	37	4	f6b9d91d46830d0d207b0abd4ee5a4942fd99774
ToppCell	normal_Lymph_Node-Myeloid_cells-CD141+_DCs\|normal_Lymph_Node / Location, Cell class and cell subclass	CD93 PRKAR2B NID1 SLC1A5	1.44e-05	179	37	4	ec995ccd6e1dbd06287ad836c232d9aed1cf94a8
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related-ICC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRKAR2B APLP2 APP WFIKKN2	1.57e-05	183	37	4	262387ee8d43b96e5f1a77c75124459a506a6172
ToppCell	3'-GW_trimst-2-SmallIntestine-Mesenchymal-stromal_related\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PRKAR2B APLP2 APP WFIKKN2	1.57e-05	183	37	4	c85a707acbcb582912e8ac080a36d05f91cfd7a2
ToppCell	droplet-Heart-nan-3m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CEP350 CD93 APLP2 VWF	1.68e-05	186	37	4	0ae5fbe9f210cb25092394267e1d3d6ed05627b8
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_naive-Z\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD93 NID1 APLP2 ACSS2	1.71e-05	187	37	4	3b1439018e265a61d9599e307a202e3c2f60ed32
ToppCell	10x_5'_v1-Non-neoplastic-Myeloid-Mono-Mono_naive\|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD93 NID1 APLP2 ACSS2	1.71e-05	187	37	4	e99bc27d212c74da37770297122a4b30445ccd0d
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma\|TCGA-Kidney / Sample_Type by Project: Shred V9	CD93 NID1 VWF ENPP3	1.75e-05	188	37	4	e711c7a46d7cfa030ca2982eacc1dae5af5788dd
ToppCell	Fetal_29-31_weeks-Mesenchymal-pericyte_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	OBSCN ITGA8 PRKAR2B NID1	1.75e-05	188	37	4	ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-C\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	1.82e-05	190	37	4	06bfb62b94b0faf467ef93d5bc5d08924c770098
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NID1 APP SLC1A5 ADAM9	1.90e-05	192	37	4	beac6b3c191b11add8e39e8d04562b478ea8929e
ToppCell	COVID-19-kidney-FLT1+PLVAP+EC\|kidney / Disease (COVID-19 only), tissue and cell type	ITGA8 CD93 NID1 APP	1.94e-05	193	37	4	479abb1cd2eb978b8a4fdb900069a6329fc8cade
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD93 NID1 VWF APP	1.98e-05	194	37	4	ea5e1bc8d9e27cabfe1fb833ca47ec0893593b12
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Scavenging_endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	CD93 NID1 VWF APP	1.98e-05	194	37	4	cceb7c88492bb6cd531e1c2651638da1ddf30931
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	2.02e-05	195	37	4	4658fb197657d7692ee344ae76b11b0210c418ba
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 CD93 VWF APP	2.06e-05	196	37	4	7cbb19108b4553ef60ef5c230a29de1662c02efe
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 CD93 VWF APP	2.06e-05	196	37	4	4cd1e6b7a791e11a40b19f971b7011bd11fe6273
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 CD93 VWF APP	2.06e-05	196	37	4	d37f714d4fb57e958f3738fdda085560813e5bb5
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-A\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	2.10e-05	197	37	4	9244f087ba4b60fdc81d54ce91860de715b3e12c
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	2.14e-05	198	37	4	218f33e068eb126458ec33176de3cfa6fc06ddf0
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 CD93 VWF APP	2.14e-05	198	37	4	1378c6d4ceb84b42fdd6556be3296df7a8059e6e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	2.14e-05	198	37	4	7cddd474416651088a4e08edfc0ac420ff10a5fe
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	2.14e-05	198	37	4	e1fa02184ce93c4f8aa5cf04b70949cd4c425ff0
ToppCell	normal_Lung-Fibroblasts-COL13A1+_matrix_FBs\|Fibroblasts / Location, Cell class and cell subclass	ITGA8 APLP2 SLC1A5 ADAM9	2.14e-05	198	37	4	e0e47cf65774191981840b22905b2094b95abe0f
ToppCell	mLN-Dendritic_cell-cDC1\|mLN / Region, Cell class and subclass	CD93 PRKAR2B NID1 SLC1A5	2.19e-05	199	37	4	3e25f096ba69fa43ae08adf9ef194ec7ba463fcf
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	2.19e-05	199	37	4	0602e2b2aa56d106da63bd342a38bef437b4d496
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_arterial-F\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ITGA8 CD93 NID1 VWF	2.19e-05	199	37	4	463ba77dc4c85eebb343f29a42c7ac889b0497c9
ToppCell	3'-Child04-06-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD93 VWF APP SPINK5	2.19e-05	199	37	4	57709dc893da8d9333830b8277a6d92e25aa8bc0
ToppCell	mLN-(5)_Dendritic_cell-(51)_cDC1\|mLN / shred on region, Cell_type, and subtype	CD93 PRKAR2B NID1 SLC1A5	2.19e-05	199	37	4	041353e2d06241b98845a288f90339f30ea722dd
ToppCell	mLN-Macrophage-LYVE1_Macrophage\|Macrophage / Region, Cell class and subclass	HERC1 APP ADAM9 SUPT16H	2.23e-05	200	37	4	e3c15e0e1c2602b0cc9ab8cc50c978d265350c94
ToppCell	PBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SPINT3 XG FCRL3	1.91e-04	135	37	3	7743a01dc9c4542e910e7c0fe046004692a680bf
ToppCell	LPS-IL1RA-Endothelial-Epi-like-Alv_Cap\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	AGPS APEX2 SPINK5	2.03e-04	138	37	3	5f8ac8f67e34a7cf560099208e6884102532391e
ToppCell	Control-Endothelial_cells-Inflamed_endothelial_cells\|Control / group, cell type (main and fine annotations)	CD93 VWF APP	3.14e-04	160	37	3	958256e3d3836160763b82bb48f794087918d935
ToppCell	COVID-19-kidney-Epithelial_(EC)\|kidney / Disease (COVID-19 only), tissue and cell type	ITGA8 CD93 VWF	3.14e-04	160	37	3	0d4880f85565d8c540c94a8f8109147b3029279a
ToppCell	Severe-B_naive-11\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	APLP2 FCRL3 FIGNL2	3.20e-04	161	37	3	ad3b58e3a8b59a609c8d2d2690d15218d18eabbd
ToppCell	droplet-Thymus-nan-21m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	OBSCN ITGA8 VWF	3.20e-04	161	37	3	441ebd3c029861d833fbcf8a68fc740d9de8ef2f
ToppCell	ASK452-Endothelial-Endothelium\|Endothelial / Donor, Lineage and Cell class of Lung cells from Dropseq	CD93 VWF	3.21e-04	32	37	2	fd0777da59e8ac3e0f766071977cb169d058e5ae
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCRL4 GPC2 FCRL3	3.25e-04	162	37	3	08b7f06580d516307516d5475a5dae0fa040f1a4
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCRL4 GPC2 FCRL3	3.25e-04	162	37	3	1fda21a303a08aff6f97819cd8766cd18784d8bc
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCRL4 GPC2 FCRL3	3.25e-04	162	37	3	fc313fb2c55957faa8c9ca4023b3fce63527c267
ToppCell	3'-Airway_Nasal-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FCRL4 GPC2 FCRL3	3.25e-04	162	37	3	002fac3c5c3030950f9eb9e887d59902586d8452
ToppCell	10x5'-bone_marrow-Lymphocytic_B-ABC_aged-B_naive\|bone_marrow / Manually curated celltypes from each tissue	SCRN1 FCRL4 FCRL3	3.25e-04	162	37	3	44832055b11a789e320c802aadb345e065defc8f
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CD93 VWF APP	3.31e-04	163	37	3	977a970b1296234c22178420294cea73506ee02f
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_bronchial_vessel-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CD93 VWF APP	3.31e-04	163	37	3	ba7d02db0f0e2f9916ec8db52c067c87b6917c23
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	3.62e-04	168	37	3	3bddf411a60137a8883fc9e77586e4719b0d6067
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	3.62e-04	168	37	3	b6d948857ee652351ddbe383b75fdd1721cd8721
ToppCell	BAL-Mild-Lymphocyte-B\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCRL4 FCRL3 ESPNL	3.68e-04	169	37	3	307571e57c3bfdf15f0fe1a8b36585e8e4f8a207
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell-B_activate-7\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCRL4 FCRL3 ESPNL	3.75e-04	170	37	3	ee2ee67d90ae4596de8ccd620e37c82cf51651d4
ToppCell	BAL-Mild-Lymphocyte-B-B_cell-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCRL4 FCRL3 ESPNL	3.75e-04	170	37	3	d7ca0c6ce5d2b7de99346f87e07aa7fe728fa08a
ToppCell	BAL-Mild-Lymphocyte-B-B_cell\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FCRL4 FCRL3 ESPNL	3.75e-04	170	37	3	52787f6d529c285d9f0c04cc022710ead5b89b3f
ToppCell	Control-Fibroblasts-Pericytes\|Control / group, cell type (main and fine annotations)	OBSCN PRKAR2B NID1	3.81e-04	171	37	3	080003f698f867935c2bfc55d241d3650f45a0ab
ToppCell	normal_Lung-T/NK_cells-CD8+/CD4+_Mixed_Th\|T/NK_cells / Location, Cell class and cell subclass	CEP350 GPC2 APP	3.88e-04	172	37	3	0657c736f3c52d25cf7f652eac005ddcde9232ef
ToppCell	Club-club-3\|World / Class top	ACSS2 WFIKKN2 SPINK5	3.88e-04	172	37	3	34fbb82a2ec77dd183cf26b38edeb7e936b707bc
ToppCell	Adult-Mesenchymal-pericyte_cell-D175\|Adult / Lineage, Cell type, age group and donor	OBSCN PRKAR2B NID1	3.94e-04	173	37	3	fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCell	droplet-Heart-4Chambers-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 VWF ESPNL	3.94e-04	173	37	3	9a04271c51fae34f547db3206f9ff5857686e45c
ToppCell	ILEUM-inflamed-(1)_T_cell-(1)_T_(gd)\|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)	PRKAR2B FCRL4 FCRL3	3.94e-04	173	37	3	62f2f42f54c9c6941bf888956be40230f92c883e
ToppCell	facs-Heart-RA-24m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	4.01e-04	174	37	3	42dfb6f42b72e40e203b3ef341117bccf3553d54
ToppCell	5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	OBSCN ITGA8 NID1	4.01e-04	174	37	3	f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCell	facs-Heart-RA-24m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	4.01e-04	174	37	3	f04edf2ca6788875c9918611e416fb739924382e
ToppCell	normal_Lung-Endothelial_cells-EPCs\|normal_Lung / Location, Cell class and cell subclass	CD93 VWF APP	4.15e-04	176	37	3	71d1bd425772d89d8c550b909e0ec0e36ff22a7e
ToppCell	5'-Adult-Appendix-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA8 PRKAR2B NID1	4.22e-04	177	37	3	e65c0568dc5852108e9802273499bc7cf88fafab
ToppCell	3'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	APP SLC1A5 SPINK5	4.22e-04	177	37	3	aadf1d10eccfb014cf3d621b1f01dd6d76df63ac
ToppCell	tumor_Lung-Endothelial_cells-EPCs\|tumor_Lung / Location, Cell class and cell subclass	CD93 VWF APP	4.22e-04	177	37	3	f8b152c09d56a97e8c0482fb1a3964c05f9dc8c5
ToppCell	390C-Endothelial_cells-Endothelial-E-\|390C / Donor, Lineage, Cell class and subclass (all cells)	CD93 VWF APP	4.29e-04	178	37	3	804ac3725c1f88e2212172bfb9aa01d97a735621
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	OBSCN CD93 VWF	4.29e-04	178	37	3	0139b42494c1186390b12106dea7957e2b6717c2
ToppCell	390C-Endothelial_cells-Endothelial-E\|390C / Donor, Lineage, Cell class and subclass (all cells)	CD93 VWF APP	4.29e-04	178	37	3	ad6dc4a375664c919bd48c35c48a561fc5a7de8c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 CD93 VWF	4.36e-04	179	37	3	8f9e538c822940785130297712b75131812a4603
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega\|lymph-node_spleen / Manually curated celltypes from each tissue	PRKAR2B NID1 VWF	4.36e-04	179	37	3	4e0cf069bc47328eda753a4edc7e89b8915d52bb
ToppCell	tumor_Lymph_Node_/_Brain-Myeloid_cells-CD141+_DCs\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	PRKAR2B AGPS SLC1A5	4.36e-04	179	37	3	99894067e2c2a3ed53abdc5434410c3172693496
ToppCell	Endothelial\|World / shred by cell class for turbinate	CD93 NID1 VWF	4.36e-04	179	37	3	052b2681974be00efb8503fa4e2c85d91d5ebd06
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 PRKAR2B NID1	4.43e-04	180	37	3	fdbd7c22044d9328a1e06e2f9a4451529d1df767
ToppCell	368C-Endothelial_cells-Endothelial-E\|368C / Donor, Lineage, Cell class and subclass (all cells)	CD93 VWF APP	4.43e-04	180	37	3	8ab16a0b9053bffc07b569a4f9e71749f56dde7e
ToppCell	5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-vein_endothelial_cell-EC_venous_pulmonary-EC_venous_pulmonary_L.2.2.1.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CD93 NID1 VWF	4.43e-04	180	37	3	40d4838a0ccb10d5e49266bc8a0037d27b75ccc2
ToppCell	COVID-19-kidney-PLVAP+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	ITGA8 CD93 APP	4.43e-04	180	37	3	493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell-Degenerative_Peritubular_Capilary_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CD93 VWF APP	4.43e-04	180	37	3	16728b9a1c52097e3a460534be71a476ecc54f0f
ToppCell	COVID-19_Moderate-B_intermediate\|World / disease group, cell group and cell class	FCRL4 FCRL3 ESPNL	4.43e-04	180	37	3	bd81b87a6dc81e5ab4a6c948eb0c80f14401a6a7
ToppCell	368C-Endothelial_cells-Endothelial-E-\|368C / Donor, Lineage, Cell class and subclass (all cells)	CD93 VWF APP	4.43e-04	180	37	3	394cd465b88429b70eebb2957480dffcbc51cfe7
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ITGA8 PRKAR2B NID1	4.43e-04	180	37	3	280ff5c8f292be1b88120db5ff1788b750644856
ToppCell	droplet-Mammary_Gland-nan-18m-Endothelial-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	4.50e-04	181	37	3	2e15c46e8260bb04d8264478c19a707221996026
ToppCell	facs-Thymus-Epithelium-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 APP	4.50e-04	181	37	3	bce56e12ab93693c9c04fa6aad8f2e1dff0c4d45
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Mesenchymal_2\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ITGA8 PRKAR2B NID1	4.50e-04	181	37	3	9b2d207dc9fc2228a1555ed360286bb7c2d988ff
ToppCell	droplet-Heart-nan-24m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	4.50e-04	181	37	3	859c40889ede2cbf374c4d2efbb72dc3bc6441f5
ToppCell	3'_v3-blood-Hematopoietic_Erythro-Mega-Mega-Mast\|blood / Manually curated celltypes from each tissue	PRKAR2B NID1 VWF	4.57e-04	182	37	3	1923b5669901f828e890416c22d1f1d21a4a2c6a
ToppCell	facs-Kidney-nan-3m\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	APLP2 APP PPP1CB	4.57e-04	182	37	3	4c5d14e33ebdf117b5aa9e2f57aaa89aa51f72bf
ToppCell	severe_influenza-B_intermediate\|World / disease group, cell group and cell class (v2)	FCRL4 FCRL3 WDR87	4.57e-04	182	37	3	e633a908a2fb30ed362cf22fbb8d6839f31f1751
ToppCell	COVID-19-kidney-Mito-rich_EC\|kidney / Disease (COVID-19 only), tissue and cell type	ITGA8 CD93 VWF	4.65e-04	183	37	3	3c4153479fc4ab2d073d92cee120480015555914
ToppCell	5'-Adult-LargeIntestine-Mesenchymal-myocytic-myofibroblast\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ITGA8 PRKAR2B NID1	4.65e-04	183	37	3	af8d86f15a549064530d94bd47081daf59d58ecd
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-blood_vessel_EC-cycling_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD93 VWF SPINK5	4.72e-04	184	37	3	fa38d6a8709f520a027ad7e3ff783c84187ec467
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGA8 FCRL4 FCRL3	4.72e-04	184	37	3	e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|lymph-node_spleen / Manually curated celltypes from each tissue	PRKAR2B NID1 VWF	4.72e-04	184	37	3	10607d7d92edcbb92d992900086b90b307421cc3
ToppCell	normal_Lung-Endothelial_cells-Tumor_ECs\|normal_Lung / Location, Cell class and cell subclass	CD93 VWF APP	4.72e-04	184	37	3	7ee98acda030366ac6cf3890a6d93fd0426712ed
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-Degenerative_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CD93 VWF APP	4.72e-04	184	37	3	a12a6a481e78adc62da1904431f62b119f70b15f
ToppCell	droplet-Heart-4Chambers-21m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	4.72e-04	184	37	3	f17d713af4a97dff4eeeab24c405677ef2ffcf84
ToppCell	3'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD93 VWF SPINK5	4.79e-04	185	37	3	0ab1be455f2cd883c9d1522ca78112c37833352e
ToppCell	Endothelial-A-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	CD93 XG VWF	4.79e-04	185	37	3	ae49c61f6ecf128fe2a958b8c75c83688da75f59
ToppCell	Fetal_29-31_weeks-Immune-enucleated_erythrocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PRKAR2B XG HERC1	4.79e-04	185	37	3	e8f7da9641b6cf1db1093b4f301ce828fd3a529c
ToppCell	E17.5-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ITGA8 NID1 SCRN1	4.79e-04	185	37	3	c85bba1210f1d389add3e40be9b96abac40cf8c1
ToppCell	Endothelial-A-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	CD93 XG VWF	4.79e-04	185	37	3	dee0b7ba2f338f0979d2306aedf52ac35a36b60c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-4_VIP_CHRNA2\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ITGA8 NID1 FBN3	4.79e-04	185	37	3	3189e91fe26df59bd605d2b6223ceb1779daf0b8
ToppCell	droplet-Heart-nan-18m-Endothelial\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD93 APLP2 VWF	4.79e-04	185	37	3	a32d5cb596ebac80eb1ac301055e65d420879ec8
Drug	N-benzyloxycarbonyl-valyl-leucyl-leucinal	APLP2 APP	2.57e-06	2	37	2	ctd:C495708
Disease	Fc receptor-like protein 4 measurement	FCRL4 FCRL3	7.72e-06	4	34	2	EFO_0801599
Disease	Fc receptor-like protein 3 measurement	FCRL4 FCRL3	7.72e-06	4	34	2	EFO_0008127
Disease	Alzheimer's disease 1 (implicated_via_orthology)	APLP2 APP	2.70e-05	7	34	2	DOID:0080348 (implicated_via_orthology)
Disease	mesangial proliferative glomerulonephritis (biomarker_via_orthology)	ITGA8 VWF	3.59e-05	8	34	2	DOID:4783 (biomarker_via_orthology)
Disease	end stage renal disease (is_implicated_in)	ITGA8 VWF	1.03e-03	41	34	2	DOID:783 (is_implicated_in)
Disease	Alzheimer's disease (implicated_via_orthology)	APLP2 APP	1.98e-03	57	34	2	DOID:10652 (implicated_via_orthology)
Disease	Alzheimer's disease (biomarker_via_orthology)	APP ADAM9	2.05e-03	58	34	2	DOID:10652 (biomarker_via_orthology)
Disease	IGA glomerulonephritis	FCRL4 FCRL3	2.05e-03	58	34	2	EFO_0004194
Disease	Nerve Degeneration	APLP2 APP	4.14e-03	83	34	2	C0027746
Disease	response to anticonvulsant	PRKAR2B NID1	4.33e-03	85	34	2	GO_0036277

Protein segments in the cluster

Peptide	Gene	Start	Entry
QGAAAGGYCGSRDQV	SLC1A5	31	Q15758
YGGCGGNRNNFDTEE	APP	321	P05067
DRNGSFGGQYSECRD	AKAP8	161	O43823
NNGNYRCIGYGDEND	FCRL4	161	Q96PJ5
FNNGGCHQDCFEGGD	CD93	266	Q9NPY3
GYYVTGDGCQRDQDG	ACSS2	546	Q9NR19
GLFATQNGDVGCYGN	APEX2	101	Q9UBZ4
NGGYELDRGGGNCTD	FBN3	1431	Q75N90
GQVYSFGCNDEGALG	RCC1	86	P18754
DYQQAFGNSTGGFDG	RBM14	186	Q96PK6
GGCGGNRNNFESEDY	APLP2	341	Q06481
RSQQGSFNGEDICGY	ESPNL	971	Q6ZVH7
DEDASGSGGGQQYAD	GPC2	496	Q8N158
SGGGGGNTQDECAEY	SPINK5	696	Q9NQ38
CGEGSYGRLGQGNSD	HERC1	4051	Q15751
AGYTGNGRQCVAEGS	NID1	416	P14543
NADPEGQGYCQAGFS	ITGA8	191	P53708
GQADAGEYTCEAGGQ	OBSCN	1321	Q5VST9
FSAPNYCGEFDNAGG	PPP1CB	266	P62140
TNCGGGNHGYNNEFR	ENPP3	476	O14638
GNNNGTYDGIAYFEC	CEP350	2536	Q5VT06
KGDRFGNCGFSGNEY	ADAM9	546	Q13443
SGNYSCDADNGLGAQ	FCRL3	446	Q96P31
DGVGRCVGNYDNRGS	PRKAR2B	206	P31323
RGSGQQDGASDCGYG	LCE3B	76	Q5TA77
YPAADNGECRGNGFR	FIGNL2	296	A6NMB9
GNSGGYFNDVDRDDG	XG	81	P55808
RYQGFSGEDGGSKNC	MTG2	131	Q9H4K7
NFYCPGSALGRNEGN	SUPT16H	571	Q9Y5B9
EHGQGGNYFEDANSC	SCRN1	136	Q12765
FGGLAAGEDNGQRGY	AGPS	491	O00116
CGLCGNYNGNQGDDF	VWF	521	P04275
CELFAYGGCGGNSNN	SPINT3	61	P49223
CFDQGFLYAGNQAGE	WDR87	211	Q6ZQQ6
GYGNRGAGANLNTDD	ZRANB1	596	Q9UGI0
YCVDNNQGGPGEDGA	TXLNA	86	P40222
YGGCEGNGNNFESRE	WFIKKN2	416	Q8TEU8