Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	voltage-gated potassium channel activity	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.82e-05	102	31	4	GO:0005249
GeneOntologyMolecularFunction	potassium channel activity	KCNQ2 KCNQ3 KCNQ5 KCNQ4	4.43e-05	128	31	4	GO:0005267
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	KCNQ2 KCNQ3 KCNQ5 KCNQ4	8.65e-05	152	31	4	GO:0022843
GeneOntologyMolecularFunction	potassium ion transmembrane transporter activity	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.24e-04	167	31	4	GO:0015079
GeneOntologyMolecularFunction	monoatomic cation channel activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	1.71e-04	343	31	5	GO:0005261
GeneOntologyMolecularFunction	voltage-gated monoatomic ion channel activity	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.73e-04	182	31	4	GO:0005244
GeneOntologyMolecularFunction	voltage-gated channel activity	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.81e-04	184	31	4	GO:0022832
GeneOntologyMolecularFunction	monoatomic ion channel activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	6.51e-04	459	31	5	GO:0005216
GeneOntologyMolecularFunction	metal ion transmembrane transporter activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	6.91e-04	465	31	5	GO:0046873
GeneOntologyMolecularFunction	channel activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	1.19e-03	525	31	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	1.20e-03	526	31	5	GO:0022803
GeneOntologyMolecularFunction	gated channel activity	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.69e-03	334	31	4	GO:0022836
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC25A38 KCNQ2 KCNQ3 TRPV3 KCNQ5 TOMM22 KCNQ4	1.86e-03	1180	31	7	GO:0022857
GeneOntologyMolecularFunction	molecular function activator activity	SEMA4B TBC1D22B VAC14 TBC1D4 PGLYRP1 PGF ARHGAP26	2.39e-03	1233	31	7	GO:0140677
GeneOntologyMolecularFunction	inorganic cation transmembrane transporter activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	2.59e-03	627	31	5	GO:0022890
GeneOntologyMolecularFunction	transporter activity	SLC25A38 KCNQ2 KCNQ3 TRPV3 KCNQ5 TOMM22 KCNQ4	3.07e-03	1289	31	7	GO:0005215
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	3.32e-03	664	31	5	GO:0008324
GeneOntologyMolecularFunction	inorganic molecular entity transmembrane transporter activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	5.82e-03	758	31	5	GO:0015318
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	7.03e-03	793	31	5	GO:0015075
GeneOntologyMolecularFunction	GTPase activator activity	TBC1D22B TBC1D4 ARHGAP26	9.09e-03	279	31	3	GO:0005096
GeneOntologyBiologicalProcess	regulation of action potential firing threshold	KCNQ2 KCNQ3	7.90e-06	3	34	2	GO:0099611
GeneOntologyBiologicalProcess	apoptosome assembly	KCNQ2 KCNQ3	7.90e-06	3	34	2	GO:0097314
GeneOntologyBiologicalProcess	substantia propria of cornea development	KCNQ2 KCNQ3	7.90e-06	3	34	2	GO:1903701
GeneOntologyBiologicalProcess	action potential initiation	KCNQ2 KCNQ3	2.63e-05	5	34	2	GO:0099610
GeneOntologyBiologicalProcess	inhibitory chemical synaptic transmission	KCNQ2 KCNQ3	5.51e-05	7	34	2	GO:0098977
GeneOntologyBiologicalProcess	psychomotor behavior	KCNQ2 KCNQ3	5.51e-05	7	34	2	GO:0036343
GeneOntologyBiologicalProcess	excitatory chemical synaptic transmission	KCNQ2 KCNQ3	3.12e-04	16	34	2	GO:0098976
GeneOntologyCellularComponent	voltage-gated potassium channel complex	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.25e-05	91	33	4	GO:0008076
GeneOntologyCellularComponent	potassium channel complex	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.12e-05	104	33	4	GO:0034705
GeneOntologyCellularComponent	node of Ranvier	KCNQ2 KCNQ3	4.51e-04	20	33	2	GO:0033268
GeneOntologyCellularComponent	cation channel complex	KCNQ2 KCNQ3 KCNQ5 KCNQ4	4.93e-04	235	33	4	GO:0034703
GeneOntologyCellularComponent	axon initial segment	KCNQ2 KCNQ3	9.55e-04	29	33	2	GO:0043194
GeneOntologyCellularComponent	plasma membrane protein complex	KCNQ2 KCNQ3 KCNQ5 KCNQ4 TRBV6-8 TRBV6-5	1.28e-03	785	33	6	GO:0098797
GeneOntologyCellularComponent	membrane protein complex	KCNQ2 KCNQ3 VAC14 KCNQ5 TOMM22 KCNQ4 TRBV6-8 TRBV6-5	1.88e-03	1498	33	8	GO:0098796
GeneOntologyCellularComponent	monoatomic ion channel complex	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.85e-03	378	33	4	GO:0034702
HumanPheno	Facial cyanosis	KCNQ2 KCNQ3	6.01e-06	2	13	2	HP:0034031
HumanPheno	Circumoral cyanosis	KCNQ2 KCNQ3	6.01e-06	2	13	2	HP:0032556
HumanPheno	Focal EEG discharges with secondary generalization	KCNQ2 KCNQ3	3.60e-05	4	13	2	HP:0011188
HumanPheno	Focal head nodding automatism seizure	KCNQ2 KCNQ3	5.99e-05	5	13	2	HP:0032906
HumanPheno	Neonatal electro-clinical non-motor seizure	KCNQ2 KCNQ3	5.99e-05	5	13	2	HP:0032812
HumanPheno	Neonatal seizure with electrographic correlate	KCNQ2 KCNQ3	5.99e-05	5	13	2	HP:0032808
HumanPheno	Neonatal electro-clinical seizure	KCNQ2 KCNQ3	5.99e-05	5	13	2	HP:0032809
HumanPheno	Neonatal electro-clinical seizure with behavior arrest	KCNQ2 KCNQ3	5.99e-05	5	13	2	HP:0032823
HumanPheno	Normal interictal EEG	KCNQ2 KCNQ3	8.97e-05	6	13	2	HP:0002372
HumanPheno	Eyelid myoclonia seizure	KCNQ2 KCNQ3	1.25e-04	7	13	2	HP:0032678
HumanPheno	Focal autonomic seizure	KCNQ2 KCNQ3	3.26e-04	11	13	2	HP:0011154
HumanPheno	Neonatal seizure	KCNQ2 KCNQ3	3.26e-04	11	13	2	HP:0032807
HumanPheno	Increased theta frequency activity in EEG	KCNQ2 KCNQ3	3.26e-04	11	13	2	HP:0031535
HumanPheno	Focal automatism seizure	KCNQ2 KCNQ3	3.91e-04	12	13	2	HP:0032898
HumanPheno	Facial tics	KCNQ2 KCNQ3	6.20e-04	15	13	2	HP:0011468
MousePheno	abnormal afterhyperpolarization	KCNQ2 KCNQ3 KCNQ5	4.29e-06	17	27	3	MP:0003412
Domain	K_chnl_volt-dep_KCNQ	KCNQ2 KCNQ3 KCNQ5 KCNQ4	3.54e-11	5	32	4	IPR003937
Domain	KCNQ_channel	KCNQ2 KCNQ3 KCNQ5 KCNQ4	3.54e-11	5	32	4	PF03520
Domain	K_chnl_volt-dep_KCNQ_C	KCNQ2 KCNQ3 KCNQ5 KCNQ4	3.54e-11	5	32	4	IPR013821
Domain	VG_K_chnl	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.80e-07	33	32	4	IPR028325
Domain	Ion_trans_dom	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	1.37e-06	114	32	5	IPR005821
Domain	Ion_trans	KCNQ2 KCNQ3 TRPV3 KCNQ5 KCNQ4	1.37e-06	114	32	5	PF00520
Domain	KCNQC3-Ank-G_bd	KCNQ2 KCNQ3	2.84e-06	2	32	2	PF11956
Domain	Ankyrin-G_BS	KCNQ2 KCNQ3	2.84e-06	2	32	2	IPR020969
Domain	K_chnl_volt-dep_KCNQ2	KCNQ2 KCNQ5	2.84e-06	2	32	2	IPR003947
Domain	TBC	TBC1D22B TBC1D4	3.18e-03	49	32	2	SM00164
Domain	RabGAP-TBC	TBC1D22B TBC1D4	3.71e-03	53	32	2	PF00566
Domain	adh_short	FASN DHRS11	3.99e-03	55	32	2	PF00106
Domain	TBC_RABGAP	TBC1D22B TBC1D4	3.99e-03	55	32	2	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D22B TBC1D4	3.99e-03	55	32	2	IPR000195
Domain	Nucleotide-diphossugar_trans	CERCAM CHSY3	9.93e-03	88	32	2	IPR029044
Pathway	BIOCARTA_RACC_PATHWAY	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.22e-08	15	26	4	M22002
Pathway	REACTOME_VOLTAGE_GATED_POTASSIUM_CHANNELS	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.07e-06	43	26	4	M1056
Pathway	REACTOME_POTASSIUM_CHANNELS	KCNQ2 KCNQ3 KCNQ5 KCNQ4	3.55e-05	103	26	4	M1073
Pathway	WP_ACETAMINOPHEN_IN_ANALGESIA_AND_ANTIPYRESIS	KCNQ2 KCNQ3	1.17e-04	9	26	2	M48307
Pathway	WP_KCNQ2RELATED_EPILEPSIES	KCNQ2 KCNQ3	5.49e-04	19	26	2	M48320
Pubmed	The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.	KCNQ2 KCNQ3 KCNQ5 KCNQ4	4.83e-12	5	36	4	20132415
Pubmed	Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase.	KCNQ2 KCNQ3 KCNQ5 KCNQ4	4.83e-12	5	36	4	15304482
Pubmed	Tannic acid activates the Kv7.4 and Kv7.3/7.5 K(+) channels expressed in HEK293 cells and reduces tension in the rat mesenteric arteries.	KCNQ3 KCNQ5 KCNQ4	1.02e-09	3	36	3	26969140
Pubmed	Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation.	KCNQ2 KCNQ3 KCNQ5	1.02e-09	3	36	3	12890507
Pubmed	Homomeric and heteromeric assembly of KCNQ (Kv7) K+ channels assayed by total internal reflection fluorescence/fluorescence resonance energy transfer and patch clamp analysis.	KCNQ3 KCNQ5 KCNQ4	1.02e-09	3	36	3	18786918
Pubmed	Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.	KCNQ2 KCNQ3 KCNQ4	4.07e-09	4	36	3	10713961
Pubmed	A carboxy-terminal domain determines the subunit specificity of KCNQ K+ channel assembly.	KCNQ2 KCNQ3 KCNQ4	4.07e-09	4	36	3	12524525
Pubmed	The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels.	KCNQ2 KCNQ3 KCNQ5	2.03e-08	6	36	3	12032157
Pubmed	Novel expression and regulation of voltage-dependent potassium channels in placentas from women with preeclampsia.	KCNQ3 KCNQ5 KCNQ4	2.03e-08	6	36	3	21730298
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCNQ2 KCNQ3 KCNQ5 KCNQ4	8.60e-08	40	36	4	16382104
Pubmed	Conditional transgenic suppression of M channels in mouse brain reveals functions in neuronal excitability, resonance and behavior.	KCNQ2 KCNQ3	1.04e-06	2	36	2	15608631
Pubmed	Benign neonatal sleep myoclonus: an autosomal dominant form not allelic to KCNQ2 or KCNQ3.	KCNQ2 KCNQ3	1.04e-06	2	36	2	22447848
Pubmed	Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels.	KCNQ2 KCNQ3	1.04e-06	2	36	2	16319223
Pubmed	Electroconvulsive seizure thresholds and kindling acquisition rates are altered in mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions.	KCNQ2 KCNQ3	1.04e-06	2	36	2	19453707
Pubmed	Pathogenic plasticity of Kv7.2/3 channel activity is essential for the induction of tinnitus.	KCNQ2 KCNQ3	1.04e-06	2	36	2	23716673
Pubmed	Developmental changes in KCNQ2 and KCNQ3 expression in human brain: possible contribution to the age-dependent etiology of benign familial neonatal convulsions.	KCNQ2 KCNQ3	1.04e-06	2	36	2	18166285
Pubmed	KCNQ4, a novel potassium channel expressed in sensory outer hair cells, is mutated in dominant deafness.	KCNQ3 KCNQ4	1.04e-06	2	36	2	10025409
Pubmed	Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels.	KCNQ2 KCNQ3	1.04e-06	2	36	2	23650395
Pubmed	Heteromeric Assembly of Truncated Neuronal Kv7 Channels: Implications for Neurologic Disease and Pharmacotherapy.	KCNQ2 KCNQ3	1.04e-06	2	36	2	32580997
Pubmed	Mouse models of human KCNQ2 and KCNQ3 mutations for benign familial neonatal convulsions show seizures and neuronal plasticity without synaptic reorganization.	KCNQ2 KCNQ3	1.04e-06	2	36	2	18483067
Pubmed	Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.	KCNQ2 KCNQ3	1.04e-06	2	36	2	9872318
Pubmed	KCNQ channels show conserved ethanol block and function in ethanol behaviour.	KCNQ2 KCNQ3	1.04e-06	2	36	2	23209695
Pubmed	KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.	KCNQ2 KCNQ3	1.04e-06	2	36	2	9836639
Pubmed	Impacted spike frequency adaptation associated with reduction of KCNQ2/3 exacerbates seizure activity in temporal lobe epilepsy.	KCNQ2 KCNQ3	1.04e-06	2	36	2	38049972
Pubmed	Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current.	KCNQ2 KCNQ3	1.04e-06	2	36	2	24843134
Pubmed	Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current.	KCNQ2 KCNQ3	1.04e-06	2	36	2	10684873
Pubmed	Early-onset epileptic encephalopathy caused by gain-of-function mutations in the voltage sensor of Kv7.2 and Kv7.3 potassium channel subunits.	KCNQ2 KCNQ3	1.04e-06	2	36	2	25740509
Pubmed	Development and validation of a medium-throughput electrophysiological assay for KCNQ2/3 channel openers using QPatch HT.	KCNQ2 KCNQ3	1.04e-06	2	36	2	23002961
Pubmed	Expression and localization of K channels KCNQ2 and KCNQ3 in the mammalian cochlea.	KCNQ2 KCNQ3	1.04e-06	2	36	2	18827480
Pubmed	Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.	KCNQ5 KCNQ4	1.04e-06	2	36	2	18536747
Pubmed	Functional analysis of novel KCNQ2 and KCNQ3 gene variants found in a large pedigree with benign familial neonatal convulsions (BFNC).	KCNQ2 KCNQ3	1.04e-06	2	36	2	16235065
Pubmed	Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels.	KCNQ2 KCNQ3	1.04e-06	2	36	2	10953053
Pubmed	Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells.	KCNQ3 KCNQ5	1.04e-06	2	36	2	11159685
Pubmed	Does diacylglycerol regulate KCNQ channels?	KCNQ2 KCNQ3	1.04e-06	2	36	2	16721610
Pubmed	Rapid chemically induced changes of PtdIns(4,5)P2 gate KCNQ ion channels.	KCNQ2 KCNQ3	1.04e-06	2	36	2	16990515
Pubmed	Novel role of KCNQ2/3 channels in regulating neuronal cell viability.	KCNQ2 KCNQ3	1.04e-06	2	36	2	20885443
Pubmed	The novel anticonvulsant retigabine activates M-currents in Chinese hamster ovary-cells tranfected with human KCNQ2/3 subunits.	KCNQ2 KCNQ3	1.04e-06	2	36	2	10713399
Pubmed	Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine.	KCNQ2 KCNQ3	1.04e-06	2	36	2	10908292
Pubmed	KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.	KCNQ2 KCNQ5	1.04e-06	2	36	2	35320039
Pubmed	The Kv7.2/Kv7.3 heterotetramer assembles with a random subunit arrangement.	KCNQ2 KCNQ3	1.04e-06	2	36	2	22334706
Pubmed	Calmodulin orchestrates the heteromeric assembly and the trafficking of KCNQ2/3 (Kv7.2/3) channels in neurons.	KCNQ2 KCNQ3	1.04e-06	2	36	2	24333508
Pubmed	Three mechanisms underlie KCNQ2/3 heteromeric potassium M-channel potentiation.	KCNQ2 KCNQ3	1.04e-06	2	36	2	15483133
Pubmed	Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium.	KCNQ2 KCNQ3	1.04e-06	2	36	2	12832524
Pubmed	C-terminal interaction of KCNQ2 and KCNQ3 K+ channels.	KCNQ2 KCNQ3	1.04e-06	2	36	2	12640002
Pubmed	Direct neurotransmitter activation of voltage-gated potassium channels.	KCNQ3 KCNQ5	1.04e-06	2	36	2	29748663
Pubmed	KCNQ2 and KCNQ3 mutations contribute to different idiopathic epilepsy syndromes.	KCNQ2 KCNQ3	1.04e-06	2	36	2	18625963
Pubmed	KCNQ Potassium Channels Modulate Sensitivity of Skin Down-hair (D-hair) Mechanoreceptors.	KCNQ2 KCNQ3	1.04e-06	2	36	2	26733196
Pubmed	Inactivation as a new regulatory mechanism for neuronal Kv7 channels.	KCNQ5 KCNQ4	1.04e-06	2	36	2	17237198
Pubmed	N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.	KCNQ2 KCNQ3	1.04e-06	2	36	2	18089837
Pubmed	Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.	KCNQ5 KCNQ4	1.04e-06	2	36	2	19389803
Pubmed	Structural Determinants of Kv7.5 Potassium Channels That Confer Changes in Phosphatidylinositol 4,5-Bisphosphate (PIP2) Affinity and Signaling Sensitivities in Smooth Muscle Cells.	KCNQ5 KCNQ4	1.04e-06	2	36	2	31871302
Pubmed	Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.	KCNQ5 KCNQ4	1.04e-06	2	36	2	23408425
Pubmed	KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum.	KCNQ2 KCNQ3	1.04e-06	2	36	2	14534157
Pubmed	Disruption of the epilepsy KCNQ2 gene results in neural hyperexcitability.	KCNQ2 KCNQ3	1.04e-06	2	36	2	10854243
Pubmed	Pharmacophore modeling, 3D-QSAR, and in silico ADME prediction of N-pyridyl and pyrimidine benzamides as potent antiepileptic agents.	KCNQ2 KCNQ3	1.04e-06	2	36	2	27607834
Pubmed	The Sensorless Pore Module of Voltage-gated K+ Channel Family 7 Embodies the Target Site for the Anticonvulsant Retigabine.	KCNQ2 KCNQ3	1.04e-06	2	36	2	26627826
Pubmed	KCNQ2/3 Gain-of-Function Variants and Cell Excitability: Differential Effects in CA1 versus L2/3 Pyramidal Neurons.	KCNQ2 KCNQ3	1.04e-06	2	36	2	37607817
Pubmed	Regulation of Kv7.2/Kv7.3 channels by cholesterol: Relevance of an optimum plasma membrane cholesterol content.	KCNQ2 KCNQ3	1.04e-06	2	36	2	29474891
Pubmed	Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell.	KCNQ2 KCNQ3	1.04e-06	2	36	2	10479678
Pubmed	KCNQ2-Related Disorders	KCNQ2 KCNQ3	1.04e-06	2	36	2	20437616
Pubmed	Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy.	KCNQ2 KCNQ3	1.04e-06	2	36	2	9677360
Pubmed	Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents.	KCNQ2 KCNQ3	1.04e-06	2	36	2	19060215
Pubmed	DNA methylation and expression of KCNQ3 in bipolar disorder.	KCNQ2 KCNQ3	1.04e-06	2	36	2	25041603
Pubmed	Surface expression and single channel properties of KCNQ2/KCNQ3, M-type K+ channels involved in epilepsy.	KCNQ2 KCNQ3	1.04e-06	2	36	2	10788442
Pubmed	Potential role of KCNQ/M-channels in regulating neuronal differentiation in mouse hippocampal and embryonic stem cell-derived neuronal cultures.	KCNQ2 KCNQ3	1.04e-06	2	36	2	21466805
Pubmed	SMIT1 Modifies KCNQ Channel Function and Pharmacology by Physical Interaction with the Pore.	KCNQ2 KCNQ3	3.12e-06	3	36	2	28793216
Pubmed	Novel KCNQ2 and KCNQ3 mutations in a large cohort of families with benign neonatal epilepsy: first evidence for an altered channel regulation by syntaxin-1A.	KCNQ2 KCNQ3	3.12e-06	3	36	2	24375629
Pubmed	PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression.	REN ADCY6	3.12e-06	3	36	2	20861226
Pubmed	BCAT2 promotes melanoma progression by activating lipogenesis via the epigenetic regulation of FASN and ACLY expressions.	BCAT2 FASN	3.12e-06	3	36	2	37801083
Pubmed	Structural Insights into the M-Channel Proximal C-Terminus/Calmodulin Complex.	KCNQ2 KCNQ3	3.12e-06	3	36	2	27564677
Pubmed	Identification of potassium channel proteins Kv7.2/7.3 as common partners of the dopamine and glutamate transporters DAT and GLT-1.	KCNQ2 KCNQ3	3.12e-06	3	36	2	30885609
Pubmed	The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.	KCNQ2 KCNQ3	3.12e-06	3	36	2	34509475
Pubmed	Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus.	KCNQ2 KCNQ3	3.12e-06	3	36	2	26312501
Pubmed	Sodium and potassium channel dysfunctions in rare and common idiopathic epilepsy syndromes.	KCNQ2 KCNQ3	3.12e-06	3	36	2	19464834
Pubmed	Kv7 channels can function without constitutive calmodulin tethering.	KCNQ2 KCNQ3	3.12e-06	3	36	2	21980481
Pubmed	KCNQ2 is a nodal K+ channel.	KCNQ2 KCNQ3	3.12e-06	3	36	2	14762142
Pubmed	Differential protein kinase C-dependent modulation of Kv7.4 and Kv7.5 subunits of vascular Kv7 channels.	KCNQ5 KCNQ4	3.12e-06	3	36	2	24297175
Pubmed	Conditional deletions of epilepsy-associated KCNQ2 and KCNQ3 channels from cerebral cortex cause differential effects on neuronal excitability.	KCNQ2 KCNQ3	3.12e-06	3	36	2	24719109
Pubmed	M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.	KCNQ2 KCNQ3	3.12e-06	3	36	2	11034315
Pubmed	Possible recruitment of peripheral blood CXCR3+ CD27+ CD19+ B cells to the liver of chronic hepatitis C patients.	CXCR3 CD19	3.12e-06	3	36	2	20377416
Pubmed	Regulation of neuronal M-channel gating in an isoform-specific manner: functional interplay between calmodulin and syntaxin 1A.	KCNQ2 KCNQ3	3.12e-06	3	36	2	21976501
Pubmed	Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.	KCNQ5 KCNQ4	3.12e-06	3	36	2	17519950
Pubmed	Genetic testing in benign familial epilepsies of the first year of life: clinical and diagnostic significance.	KCNQ2 KCNQ3	6.24e-06	4	36	2	23360469
Pubmed	A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon.	KCNQ2 KCNQ3	6.24e-06	4	36	2	16525039
Pubmed	Leukemia development initiated by deletion of RBP-J: mouse strain, deletion efficiency and cell of origin.	REN CD19	6.24e-06	4	36	2	30467111
Pubmed	Chromosomal mapping of the potassium channel genes Kcnq2 and Kcnq3 in mouse.	KCNQ2 KCNQ3	6.24e-06	4	36	2	10087209
Pubmed	Ion channel expression in the developing enteric nervous system.	KCNQ2 KCNQ3 KCNQ4	7.72e-06	37	36	3	25798587
Pubmed	Activity-dependent transcriptional regulation of M-Type (Kv7) K(+) channels by AKAP79/150-mediated NFAT actions.	KCNQ2 KCNQ3	1.04e-05	5	36	2	23259949
Pubmed	An Ankyrin-G N-terminal Gate and Protein Kinase CK2 Dually Regulate Binding of Voltage-gated Sodium and KCNQ2/3 Potassium Channels.	KCNQ2 KCNQ3	1.04e-05	5	36	2	25998125
Pubmed	Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.30e-05	139	36	4	16985003
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	KCNQ2 SEMA4B VAC14 FASN SARS2 FHIP1B NUAK1 ARHGAP26	1.39e-05	1105	36	8	35748872
Pubmed	Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy.	KCNQ2 KCNQ3	1.56e-05	6	36	2	10781098
Pubmed	Calmodulin is an auxiliary subunit of KCNQ2/3 potassium channels.	KCNQ2 KCNQ3	1.56e-05	6	36	2	12223552
Pubmed	Ubiquitin-specific Protease 36 (USP36) Controls Neuronal Precursor Cell-expressed Developmentally Down-regulated 4-2 (Nedd4-2) Actions over the Neurotrophin Receptor TrkA and Potassium Voltage-gated Channels 7.2/3 (Kv7.2/3).	KCNQ2 KCNQ3	1.56e-05	6	36	2	27445338
Pubmed	Stretch-activation of angiotensin II type 1a receptors contributes to the myogenic response of mouse mesenteric and renal arteries.	KCNQ5 KCNQ4	1.56e-05	6	36	2	24838176
Pubmed	Deletion of KCNQ2/3 potassium channels from PV+ interneurons leads to homeostatic potentiation of excitatory transmission.	KCNQ2 KCNQ3	1.56e-05	6	36	2	30382937
Pubmed	Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.	KCNQ2 KCNQ3	1.58e-04	18	36	2	37321992
Pubmed	Identification of 14-3-3epsilon substrates from embryonic murine brain.	TBC1D22B TBC1D4 NUAK1	3.48e-04	132	36	3	16944949
Pubmed	Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.	FASN TOMM22 NUAK1 ANAPC2	7.66e-04	401	36	4	25852190
Pubmed	Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.	TBC1D22B TBC1D4	9.16e-04	43	36	2	19077034
Interaction	KCNQ3 interactions	KCNQ2 KCNQ3 KCNQ5 KCNQ4	6.18e-08	24	33	4	int:KCNQ3
Interaction	KCNS1 interactions	KCNQ2 KCNQ3 KCNQ4	4.76e-07	10	33	3	int:KCNS1
Interaction	KCNQ5 interactions	KCNQ2 KCNQ3 KCNQ5	2.31e-05	34	33	3	int:KCNQ5
Cytoband	19q13	KLK8 BCAT2	2.74e-04	31	36	2	19q13
Cytoband	Ensembl 112 genes in cytogenetic band chr9q34	CERCAM C9orf163 ANAPC2	2.11e-03	325	36	3	chr9q34
Cytoband	9q34.3	C9orf163 ANAPC2	3.16e-03	106	36	2	9q34.3
Cytoband	7q34	TRBV6-8 TRBV6-5	7.64e-03	167	36	2	7q34
GeneFamily	Potassium voltage-gated channels	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.76e-07	40	23	4	274
GeneFamily	Endogenous ligands\|Minor histocompatibility antigens	BCAT2 CD19	1.90e-03	51	23	2	870
GeneFamily	Short chain dehydrogenase/reductase superfamily	FASN DHRS11	4.17e-03	76	23	2	743
GeneFamily	T cell receptor beta locus at 7q34	TRBV6-8 TRBV6-5	5.42e-03	87	23	2	372
CoexpressionAtlas	gamma delta T cells, Tgd.vg2-24ahi.Th.TCRbko, TCRd+ Vg2- CD24+, Thymus, avg-3	KLK8 SEMA4B CXCR3 TBC1D22B FASN KCNQ5 PGLYRP1	2.09e-06	396	33	7	GSM605799_500
CoexpressionAtlas	alpha beta T cells, NKT.4-.Sp, TCRbeta+ aGalCer tet+ CD4-, Spleen, avg-3	KLK8 CXCR3 TBC1D22B KCNQ5 PGLYRP1 ARHGAP26	1.06e-05	331	33	6	GSM538329_500
CoexpressionAtlas	alpha beta T cells, T.8Mem.Sp.OT1.d100.LisOva, CD8+ CD45.1+, Spleen, avg-3	KLK8 CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	1.85e-05	365	33	6	GSM605904_500
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d10.LisOva, CD8+ CD45.1+, Spleen, avg-3	KLK8 CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	1.97e-05	369	33	6	GSM605891_500
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d8.LisOva, CD8+ CD45.1+, Spleen, avg-3	KLK8 CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	2.32e-05	380	33	6	GSM605901_500
CoexpressionAtlas	alpha beta T cells, NKT.44+NK1.1+.Th, aGC CD1d tet CD3e CD44 NK1.1, Thymus, avg-3	KLK8 CXCR3 TBC1D22B TBC1D4 KCNQ5 PGLYRP1	2.50e-05	385	33	6	GSM538332_500
CoexpressionAtlas	gamma delta T cells, Tgd.vg2+.act.Sp, TCRd+ Vg2+ CD44+, Spleen, avg-3	KLK8 CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	2.89e-05	395	33	6	GSM476678_500
CoexpressionAtlas	alpha beta T cells, NKT.4+.Sp, TCRb aGalCer-loaded CD1d-tetramer CD4, Spleen, avg-2	KLK8 CXCR3 TBC1D22B KCNQ5 PGLYRP1	1.52e-04	333	33	5	GSM538323_500
CoexpressionAtlas	alpha beta T cells, T.4FP3+25+.Sp, 4+ 8- GFP+ 25+, Spleen, avg-3	KLK8 SEMA4B CXCR3 TBC1D22B PGLYRP1	1.77e-04	344	33	5	GSM399365_500
CoexpressionAtlas	alpha beta T cells, NKT.4+.Sp, TCRb aGalCer-loaded CD1d tetramer CD4, Spleen, avg-1	KLK8 CXCR3 TBC1D22B KCNQ5 PGLYRP1	1.84e-04	347	33	5	GSM538322_500
CoexpressionAtlas	alpha beta T cells, NKT.4+.Lv, CD45 TCRb aGalCer-loaded CD1d tet CD4, Liver, avg-4	KLK8 CXCR3 TBC1D22B KCNQ5 ARHGAP26	1.92e-04	350	33	5	GSM538318_500
CoexpressionAtlas	alpha beta T cells, NKT.4-.Lv, CD45 TCRb aGalCer-loaded CD1d tet, Liver, avg-4	KLK8 CXCR3 TBC1D22B KCNQ5 ARHGAP26	1.95e-04	351	33	5	GSM538325_500
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d15.VSVOva, CD8+ CD45.1+, Spleen, avg-2	CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	2.22e-04	361	33	5	GSM538385_500
CoexpressionAtlas	alpha beta T cells, T.8Mem.Sp.OT1.d106.VSVOva, CD8+ CD45.1+, Spleen, avg-2	CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	2.39e-04	367	33	5	GSM538401_500
CoexpressionAtlas	NK cells, NK.49CI-.Sp, NK1.1+ CD3- Ly49C/I-, Spleen, avg-3	CXCR3 KCNQ5 PGLYRP1 CD19 ARHGAP26	2.55e-04	372	33	5	GSM538288_500
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d15.LisOva, CD8+ CD45.1+, Spleen, avg-3	KLK8 CXCR3 TBC1D22B FHIP1B ARHGAP26	2.67e-04	376	33	5	GSM605894_500
CoexpressionAtlas	alpha beta T cells, T.8Mem.Sp.OT1.d45.VSVOva, CD8+ CD45.1+, Spleen, avg-3	CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	2.91e-04	383	33	5	GSM538403_500
CoexpressionAtlas	alpha beta T cells, T.8Eff.Sp.OT1.d8.VSVOva, CD8+ CD45.1+, Spleen, avg-3	CXCR3 TBC1D22B PGLYRP1 FHIP1B ARHGAP26	3.05e-04	387	33	5	GSM538392_500
CoexpressionAtlas	NK cells, NK.b2m-.Sp, NK1.1+ TCRb-, Spleen, avg-3	CXCR3 TBC1D22B KCNQ5 PGLYRP1 ARHGAP26	3.17e-04	390	33	5	GSM538291_500
CoexpressionAtlas	NK cells, NK.DAP12-.Sp, NK1.1+ CD3-, Spleen, avg-3	CXCR3 TBC1D22B KCNQ5 PGLYRP1 ARHGAP26	3.64e-04	402	33	5	GSM538297_500
CoexpressionAtlas	NK cells, NK.Sp, NK1.1+, Spleen, avg-3	CXCR3 TBC1D22B KCNQ5 PGLYRP1 ARHGAP26	3.94e-04	409	33	5	GSM538315_500
CoexpressionAtlas	NK cells, NK.49H-.Sp, NK1.1+, Spleen, avg-3	CXCR3 TBC1D22B KCNQ5 PGLYRP1 ARHGAP26	4.12e-04	413	33	5	GSM605817_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#4_top-relative-expression-ranked_100	CHSY3 KCNQ5	5.81e-04	23	33	2	gudmap_developingLowerUrinaryTract_e14.5_ bladder_100_k4
ToppCell	droplet-Liver-LIVER_NPC-30m\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1 CD19	8.10e-06	159	36	4	997963d879e5819683793cddf5e1acff1b81a1b8
ToppCell	droplet-Liver-LIVER_NPC\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1 CD19	8.10e-06	159	36	4	e4eaa88772835d6b78e1a18a0cec52de51e80339
ToppCell	COVID-19_Severe-Treg\|World / disease group, cell group and cell class	KCNQ2 TBC1D4 LINC02902 TRBV6-5	8.51e-06	161	36	4	c6eade2c60c572d823e6e81b5e8d47078671e9b0
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 NUAK1 PGF	9.37e-06	165	36	4	e2aebb2fe197151e019371b8960f76f0c2386f08
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 NUAK1 PGF	9.37e-06	165	36	4	b087771499aeb31cc4a338d2d0a9392a4ec1ac45
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical-aged\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 NUAK1 PGF	9.37e-06	165	36	4	d8f8b088fd28a6b9dbd6b51bcaee42000e963321
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1 CD19	1.05e-05	170	36	4	26178277bf9c7f2f06b5c0b03d4b69d78e9580c4
ToppCell	COVID-19_Severe-Treg\|COVID-19_Severe / disease group, cell group and cell class	KCNQ2 TBC1D4 LINC02902 TRBV6-5	1.05e-05	170	36	4	d61269a51283125835884c4aa50623756c4fdda2
ToppCell	facs-Liver-Non-hepatocytes-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 KCNQ2 CXCR3 PGLYRP1	1.10e-05	172	36	4	b440184f2d98d2f2d59566795f44fb79c0647ca4
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERCAM MIGA1 TBC1D4 ADCY6	1.16e-05	174	36	4	7be0c6248e77f2d0260b852b01e17892f7828f1b
ToppCell	COVID-19-kidney-REN+Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	REN KCNQ5 NUAK1 PGF	1.16e-05	174	36	4	8393f0b43c767839c1630bcb952d62b42efc788d
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BCAT2 MIGA1 TBC1D4 ADCY6	1.18e-05	175	36	4	1b910c08d2bfbcc77431ee66103e63a11a9d39fe
ToppCell	PND28-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VAC14 TBC1D4 SARS2 TOMM22	1.29e-05	179	36	4	9dea57494d59abd6e8abf34e31faf53462ea0fa0
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B REN CD19 NUAK1	1.67e-05	191	36	4	4aa29337f4d2528577bb90dc4abfb6eab93e120f
ToppCell	facs-Marrow-B-cells-3m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B REN CD19 NUAK1	1.67e-05	191	36	4	318323a12029a7992f16382cb0c186f5b2e1ca47
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B REN CD19 NUAK1	1.77e-05	194	36	4	ad1aacff97beb76f4211942676e1d5e84087d44e
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SEMA4B REN CD19 NUAK1	1.77e-05	194	36	4	fdd59b1e036b2d6d8877e1a920a0e56a91a2a882
ToppCell	saliva-Severe-critical_progression_d28-40-Lymphocytic\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	SLC25A38 MIGA1 CXCR3 CD19	1.84e-05	196	36	4	c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCell	COVID-19_Mild-Neu_4\|World / 5 Neutrophil clusters in COVID-19 patients	MIGA1 NUAK1 ADCY6	1.37e-04	124	36	3	5ef9eb806fb2c8ee5aae0a75503d244b08ee10d4
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TBC1D4 CD19 ARHGAP26	1.83e-04	137	36	3	0aa4e14b32da0cda677cc0ed6ae470f6ecd77bea
ToppCell	PND07-28-samps-Lymphocyte-B_cell-B_cell_2\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SEMA4B CD19 FHIP1B	1.83e-04	137	36	3	2544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCell	PND07-28-samps-Lymphocyte-B_cell\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	SEMA4B CD19 FHIP1B	1.83e-04	137	36	3	874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCell	droplet-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLK8 TBC1D22B TBC1D4	2.35e-04	149	36	3	65778f19599b4955c0a16f0121237656449431fb
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 PGF	2.49e-04	152	36	3	ee329249a034a969a16b26a224aa04249d67382d
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 PGF	2.49e-04	152	36	3	bd1f36b436d8ab7dd8420f595b97d851eab31a38
ToppCell	NS-critical-d_0-4-Lymphoid-NKT\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	SLC25A38 CXCR3 LINC02902	2.58e-04	154	36	3	08ffa4b6f4a1c3de037acf9d30bd14c195738ad9
ToppCell	BAL-Control-cDC_12\|Control / Compartment, Disease Groups and Clusters	ABCF1 C9orf163 ADCY6	2.58e-04	154	36	3	0121d08cc527aed9b3e11ff62bb9012916f5c56b
ToppCell	PBMC-Control-Lymphocyte-B-B_cell-B_naive-B_naive-12\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SLC25A38 TRPV3 NEMP2	2.68e-04	156	36	3	7ece590fd8f29382e349dd0e5e016d2926aeb518
ToppCell	3'_v3-bone_marrow-Lymphocytic_B-Pro-B\|bone_marrow / Manually curated celltypes from each tissue	KCNQ2 CD19 PGF	2.68e-04	156	36	3	b093dbba6662e4fffc8aa577587b77f64ac44b56
ToppCell	Control-B_naive-12\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	SLC25A38 TRPV3 NEMP2	2.73e-04	157	36	3	4803f601c1ba43260aa09172acc7964aac2c8ccf
ToppCell	facs-GAT-Fat-18m-Lymphocytic-NK_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 TBC1D22B KCNQ5	2.84e-04	159	36	3	796e63f6052189106359a4e01eae3e466bf1d593
ToppCell	droplet-Marrow-nan-18m-Lymphocytic-immature_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PGLYRP1 TMEM140 DHRS11	3.00e-04	162	36	3	08ee7ae56e4927874515c47adc86dd845bf29a26
ToppCell	5'-Parenchyma_lung-Immune_Lymphocytic-Lymphocytic_B-B_cell-B_cells-B_cells_L.1.5.0.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	KCNQ2 KCNQ5 CD19	3.00e-04	162	36	3	b46158e260bd2f35702cec73e3b035e8e9ec4469
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	CERCAM TBC1D4 NEMP2	3.00e-04	162	36	3	64353d33af0e82ebb7cf2bba74d52ca0586a58fc
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.05e-04	163	36	3	d18fee517e0daed51f89703f94f218567c83cb03
ToppCell	metastatic_Brain-B_lymphocytes-Undetermined\|metastatic_Brain / Location, Cell class and cell subclass	CXCR3 KCNQ5 CD19	3.05e-04	163	36	3	4eac7fd8acdb7f09ce739335f22a879f9b8febfb
ToppCell	droplet-Kidney-nan-24m-Lymphocytic-CD45____NK_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.05e-04	163	36	3	f4a6e28ad3c1fcbf62ed9b2bf09f65d2ab0b31d1
ToppCell	368C-Lymphocytic-CD4_T-cell-Treg_cell_4\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	CERCAM TBC1D4 NEMP2	3.05e-04	163	36	3	9f5facfa1864eb63e2f8022ad7379d9252b7a254
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.05e-04	163	36	3	8569abb769543be55e066119c1dd1c505d5a177e
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 PGLYRP1 CD19	3.11e-04	164	36	3	b175258fb0885afd84d4a414c0ae441f880e8469
ToppCell	367C-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	TRPV3 CXCR3 REN	3.11e-04	164	36	3	95b800c78871354c859abaa832d778786ef7bcc0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-glomerular_mesenchymal_cell-Mesangial_Cell-mesangial_typical\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	KCNQ5 NUAK1 PGF	3.11e-04	164	36	3	b6df1e67a5ce5f2d86f4e1420f4ee931f760bf4d
ToppCell	facs-Limb_Muscle-forelimb_and_hindlimb-18m-Lymphocytic\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 PGLYRP1 CD19	3.11e-04	164	36	3	8bcfc93220d7c99dddb32b7fa7fb9aec2a1c63fa
ToppCell	droplet-Liver-Npc-21m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.16e-04	165	36	3	6708beb0e8094f30cf5cd812e6a67a6db004a580
ToppCell	PND14-Immune-Immune_Myeloid-DC-maDC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CERCAM TBC1D4 DHRS11	3.16e-04	165	36	3	1c3709ac9f96ace1f3b28e1f2f15b4a8d65885ca
ToppCell	PND14-Immune-Immune_Myeloid-DC-maDC-maDC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CERCAM TBC1D4 DHRS11	3.16e-04	165	36	3	fbc7d97e6f30975d35c76a7c97947a34cf5975d2
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 CD19	3.22e-04	166	36	3	dbb73742db00982539b1800aef8af2801b3a0598
ToppCell	-SSc-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	TRPV3 CXCR3 CD19	3.22e-04	166	36	3	bc9323de1373fdc0357e6bb46874f6c4787443a9
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNQ5 PGLYRP1 CD19	3.22e-04	166	36	3	fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-24m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 CD19	3.22e-04	166	36	3	b7027802cac6ebf3c4a19ef11c9164d92694a4eb
ToppCell	facs-Heart-RA-18m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNQ5 PGLYRP1 CD19	3.22e-04	166	36	3	33a6876d06e26176135a73a77c19e634ec53f7ce
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-medium_spiny_neuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNQ2 CHSY3 KCNQ5	3.34e-04	168	36	3	b96a48552f4236a95bbcdce2f1b05041086d7101
ToppCell	droplet-Heart-nan-18m-Hematologic-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC25A38 SARS2 PGLYRP1	3.34e-04	168	36	3	2201ae834b53cbdc085f8f02607fa5b5bd911268
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Neuronal-SPN_Neuron_STR\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNQ2 CHSY3 KCNQ5	3.34e-04	168	36	3	b87fc63f9e35dfcfc46cb129ea569e73c5e018bb
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.34e-04	168	36	3	110c3c7c322e04a684a19c2b5434a502279fd000
ToppCell	droplet-Liver-LIVER_NPC-30m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.34e-04	168	36	3	735d30cfda1889740bdeb43e39330a52e8f4d599
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CXCR3 TBC1D4 ANAPC2	3.39e-04	169	36	3	c8691c4f707d46b2865fe46eabe24ea4d03c7b43
ToppCell	droplet-Liver-Npc\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.45e-04	170	36	3	09c836840216905d545a25a4fc1bbd0699576c77
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell-Renin-positive_Juxtaglomerular_Granular_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 NUAK1	3.45e-04	170	36	3	99dd734c0972a40d5381e8e2d96bdaa31f6d06e6
ToppCell	367C-Myeloid-Dendritic-pDC\|Dendritic / Donor, Lineage, Cell class and subclass (all cells)	TRPV3 CXCR3 REN	3.45e-04	170	36	3	fbb7019c6fba87326702b51f6819ea1af5f3a9b7
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal--glomerular_mesenchymal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 NUAK1	3.45e-04	170	36	3	3a14eeae221b8bb0bd0dadcb8e7a603431240a1e
ToppCell	droplet-Liver-LIVER-NPC-1m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 KCNQ5	3.45e-04	170	36	3	bcbe5c44ef708c5f01dc7dd9aec7b436e1a62d56
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Mesenchymal-\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	REN KCNQ5 NUAK1	3.45e-04	170	36	3	cdb6fad277f284c3fd5a6f45672a8edc24715882
ToppCell	Adult-Immune-B_cell-D175\|Adult / Lineage, Cell type, age group and donor	TRPV3 KCNQ5 CD19	3.51e-04	171	36	3	355a246f3395900342d400f6f7c6640cba0d4d5d
ToppCell	facs-Thymus-Flowthrough-24m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.51e-04	171	36	3	1064c20c37fae6cefb2eb4fa0628e4037a78179c
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 TBC1D22B SARS2	3.51e-04	171	36	3	246fc7edcefc47437d1df6029f295aca3b34b2b2
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.51e-04	171	36	3	872b3b33cd3893d63c45617db0269692430b0e8b
ToppCell	facs-Thymus-Flowthrough-24m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.51e-04	171	36	3	e2b72282244dee008e3b5d03667be9f26b7c2f6d
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-Ly6g5b+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 TBC1D22B SARS2	3.51e-04	171	36	3	1fb4e11f92b48dc2d6e553c22e2571bbd8c223c6
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNQ2 KCNQ3 SEMA4B	3.57e-04	172	36	3	0c2d0bb767e5ce089b42ad49e8b303a103de2d5c
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 CD19 PGF	3.57e-04	172	36	3	e04b1788f2074e66dff00cac734c8ee2cfefca6e
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-NK/T\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.57e-04	172	36	3	f45489e80c59b824846ffda675de0d118a8b850c
ToppCell	AT1-AT2_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	KCNQ3 BCAT2 ADCY6	3.57e-04	172	36	3	0be41df5d35d818deb7316ac21c9366eb4b7bfd1
ToppCell	E16.5-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif\|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC25A38 KLK8 NUAK1	3.57e-04	172	36	3	8a6a2b4c6654bc976e60a02d0e7303a9071ed55f
ToppCell	droplet-Lung-1m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLK8 CXCR3 TBC1D4	3.57e-04	172	36	3	30f4979abf0218618a56afb06aa6afc23ad838ec
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Thick_Ascending_Limb_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	KCNQ2 KCNQ3 SEMA4B	3.57e-04	172	36	3	eeed177a03c116e9815a8e086d24efc9643b16a4
ToppCell	facs-Spleen-nan-24m-Lymphocytic-Cd3e_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 TBC1D4	3.63e-04	173	36	3	f2eeff86e7dc7f4e3c36f775777d56685d7096cf
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D4 KCNQ5 FHIP1B	3.63e-04	173	36	3	53e97835d7a518c278e7b90a0734eb0095d6aa33
ToppCell	droplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBC1D4 KCNQ5 FHIP1B	3.63e-04	173	36	3	117163c5cd2b7aaa1c0682c8ac44b4249df4d2f8
ToppCell	droplet-Thymus-nan-24m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.63e-04	173	36	3	6bb98b0776151d726c2962a96f3411213aa86b21
ToppCell	droplet-Lung-LUNG-1m-Myeloid-basophil\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TBC1D4 KCNQ5 FHIP1B	3.63e-04	173	36	3	889a880de5fc19d26b82cfef3067869a28ef17ca
ToppCell	PND07-Immune-Immune_Myeloid-DC-cDC1-cDC1_prolif\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC25A38 TBC1D4 ARHGAP26	3.63e-04	173	36	3	28c98a9a54aa2cfa67464db4f628c9357ad185b9
ToppCell	droplet-Lung-1m-Hematologic-myeloid-Basophil/Mast_cell-basophil_l26\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TBC1D4 KCNQ5 FHIP1B	3.63e-04	173	36	3	01df9baeedf30e3a4891738554cdd300394dbb96
ToppCell	facs-SCAT-Fat-24m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|SCAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.70e-04	174	36	3	87fa5deff5c1aabb342d674f05ad17c4c0e50d01
ToppCell	Control-Lymphoid-Tregs\|Lymphoid / Condition, Lineage and Cell class	FASN TBC1D4 TRBV6-5	3.70e-04	174	36	3	522a6d5d9809271c63b85f62ac6ec52a6e3c355e
ToppCell	droplet-Spleen-nan-24m-Lymphocytic-T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 TBC1D4	3.70e-04	174	36	3	919fc124affc69acfd8f575f2c372674f3d2625e
ToppCell	PBMC-Convalescent-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-10\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SEMA4B TRPV3 CD19	3.70e-04	174	36	3	59ccc5a82507463e0a316ba6286cb25ec1a4091b
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-pericyte_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNQ5 KCNQ4 PGF	3.76e-04	175	36	3	a7310950e8d51b3004ea3aee8ce9948fe8655112
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_memory-B_memory-6\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SEMA4B CXCR3 CD19	3.76e-04	175	36	3	1b3510e9078eec7cfc5805043e435e9e5e0f0877
ToppCell	droplet-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	KLK8 CXCR3 PGLYRP1	3.76e-04	175	36	3	f1d91cd49308cb501864cd16befaa43d6da828ca
ToppCell	facs-Lung-EPCAM-18m-Mesenchymal-Pericyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNQ5 KCNQ4 PGF	3.76e-04	175	36	3	d2ff8fedca9039cbd45cfd9dec88f4edbe7fe4fc
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN4_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.76e-04	175	36	3	a7269351ce6afbd469c79174aa88be84d4f7e0b6
ToppCell	P15-Endothelial-lymphatic_endothelial_cell-endothelial_cell_of_lymphatic_vessel\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TBC1D4 PGLYRP1 PGF	3.76e-04	175	36	3	84d252f3e432231687613299bbea14978bb4b06b
ToppCell	droplet-Thymus-nan-24m-Lymphocytic-DN4\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.76e-04	175	36	3	1fa85b28d0e4d1d8d584516325a46f69dc6fbe54
ToppCell	droplet-Liver-Npc-18m-Lymphocytic-NK_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KLK8 CXCR3 PGLYRP1	3.76e-04	175	36	3	f12e230a7d0d265542c5698231a3eb0876ac4cc8
ToppCell	P15-Endothelial-lymphatic_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TBC1D4 PGLYRP1 PGF	3.76e-04	175	36	3	a00c6fa9b33640710dd05a3799031147196f0986
ToppCell	droplet-Liver-Npc-21m-Lymphocytic\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CXCR3 PGLYRP1 CD19	3.76e-04	175	36	3	046e841811b22c39f80a9752f3223c1906de6f20
ToppCell	droplet-Lung-nan-18m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERCAM TBC1D4 ADCY6	3.82e-04	176	36	3	24b2e94ee5defcefb64a1f2447a2cc71b015b0fd
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CERCAM TBC1D4 ARHGAP26	3.82e-04	176	36	3	327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCell	Adult-Immune-B_cell\|Adult / Lineage, Cell type, age group and donor	TRPV3 KCNQ5 CD19	3.82e-04	176	36	3	4aa00dcde907ad83d3aa4bb10439b7b5c4be1e5d
Drug	Quinazolinones	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.07e-11	5	34	4	ctd:D052999
Drug	N-(1-(3-morpholin-4-ylphenyl)ethyl)-3-phenylacrylamide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	6.20e-11	6	34	4	ctd:C476437
Drug	isovaleramide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.89e-10	8	34	4	CID000010930
Drug	eslicarbazepine acetate	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.89e-10	8	34	4	CID000179344
Drug	valrocemide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.89e-10	8	34	4	CID006918293
Drug	BMS-204352	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.93e-09	13	34	4	CID000214350
Drug	ezogabine	KCNQ2 KCNQ3 KCNQ4	3.04e-09	3	34	3	ctd:C101866
Drug	benzanilide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	7.45e-09	16	34	4	CID000007168
Drug	carisbamate	KCNQ2 KCNQ3 KCNQ5 KCNQ4	7.45e-09	16	34	4	CID006918474
Drug	Thallium	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.97e-08	22	34	4	ctd:D013793
Drug	CCD 1042	KCNQ2 KCNQ3 KCNQ5 KCNQ4	5.13e-08	25	34	4	CID000038022
Drug	sotalol	KCNQ2 KCNQ3 REN KCNQ5 KCNQ4	7.63e-08	73	34	5	CID000005253
Drug	rufinamide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	9.58e-08	29	34	4	CID000129228
Drug	valnoctamide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.27e-07	31	34	4	CID000020140
Drug	XE991	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.64e-07	33	34	4	CID000656732
Drug	LY 300164	KCNQ2 KCNQ3 KCNQ5 KCNQ4	4.91e-07	43	34	4	CID000126756
Drug	linopirdine	KCNQ2 KCNQ3 KCNQ5 KCNQ4	4.91e-07	43	34	4	CID000003932
Drug	AC1Q646P	KCNQ2 KCNQ3 KCNQ5 KCNQ4	7.06e-07	47	34	4	CID000005673
Drug	Pro-val	KCNQ2 KCNQ3 KCNQ5 KCNQ4	7.06e-07	47	34	4	CID000142984
Drug	retigabine	KCNQ2 KCNQ3 KCNQ5 KCNQ4	7.70e-07	48	34	4	CID000121892
Drug	lacosamide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.07e-06	52	34	4	CID000219078
Drug	E 4031	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.24e-06	54	34	4	CID000003184
Drug	LMWH	KLK8 KCNQ2 KCNQ3 REN KCNQ5 KCNQ4 PGF ADCY6	4.60e-06	663	34	8	CID000000772
Drug	linopirdine	KCNQ2 KCNQ3	6.49e-06	3	34	2	ctd:C061017
Drug	(R)-N-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide	KCNQ2 KCNQ4	6.49e-06	3	34	2	ctd:C576869
Drug	verapamil	KCNQ2 KCNQ3 REN ABCF1 KCNQ5 KCNQ4 ADCY6	6.66e-06	490	34	7	CID000002520
Drug	PGF-MUM	REN PGF	1.30e-05	4	34	2	CID006443310
Drug	10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone	KCNQ2 KCNQ3	1.30e-05	4	34	2	ctd:C112297
Drug	kinin 9	KLK8 KCNQ2 KCNQ3 TRPV3 REN ADCY6	1.45e-05	363	34	6	CID000006026
Drug	diazoxide	KCNQ2 KCNQ3 REN KCNQ5 KCNQ4	2.07e-05	227	34	5	CID000003019
Drug	niflumic acid	KCNQ2 KCNQ3 KCNQ5 KCNQ4	3.53e-05	125	34	4	CID000004488
Drug	dobutamine	REN TBC1D4 SARS2 ADCY6	5.50e-05	140	34	4	CID000036811
Drug	Diclofenac	KCNQ2 KCNQ3	6.03e-05	8	34	2	DB00586
Drug	Magnesium Sulfate	KLK8 REN	6.03e-05	8	34	2	ctd:D008278
Drug	DiC8	KCNQ2 KCNQ3 KCNQ4 ADCY6	6.48e-05	146	34	4	CID000001323
Drug	tremorine	KCNQ2 KCNQ3	7.74e-05	9	34	2	CID000005534
Drug	potassium	KLK8 KCNQ2 KCNQ3 REN KCNQ5 KCNQ4 PGF ADCY6	9.32e-05	1008	34	8	CID000000813
Drug	Benzimidazoles	KCNQ2 KCNQ3	9.67e-05	10	34	2	ctd:D001562
Drug	histamine	KLK8 KCNQ2 KCNQ3 REN PGF ADCY6	1.61e-04	560	34	6	CID000000774
Drug	Methotrexate [59-05-2]; Up 200; 8.8uM; HL60; HG-U133A	VAC14 TBC1D4 PGF DHRS11	1.83e-04	191	34	4	2041_UP
Drug	Hymecromone [90-33-5]; Up 200; 22.8uM; PC3; HT_HG-U133A	TBC1D22B CD19 ADCY6 ARHGAP26	2.02e-04	196	34	4	4623_UP
Drug	Chlormezanone [80-77-3]; Up 200; 14.6uM; PC3; HT_HG-U133A	TBC1D22B PGF ADCY6 ARHGAP26	2.06e-04	197	34	4	4636_UP
Drug	Alfaxalone [23930-19-0]; Up 200; 12uM; HL60; HT_HG-U133A	KCNQ3 CXCR3 TBC1D22B ADCY6	2.10e-04	198	34	4	3135_UP
Drug	Acrylamide	KCNQ2 KCNQ3 KCNQ5 KCNQ4	2.14e-04	199	34	4	ctd:D020106
Drug	bicyclo-PGE2	REN PGF	2.25e-04	15	34	2	CID005283043
Drug	glibenclamide	KCNQ2 KCNQ3 KCNQ5 KCNQ4 ADCY6	2.41e-04	382	34	5	CID000003488
Drug	norsolorinic acid	FASN SARS2	2.90e-04	17	34	2	CID000025102
Drug	adenosine 3',5'-cyclic phosphate	KCNQ2 KCNQ3 FASN REN KCNQ4 PGF ADCY6	3.26e-04	907	34	7	CID000000274
Drug	meclofenamate	KLK8 REN PGF	3.72e-04	94	34	3	CID000004036
Drug	tetraethylammonium	KCNQ2 KCNQ3 KCNQ5 KCNQ4	4.09e-04	236	34	4	CID000005413
Disease	long QT syndrome (implicated_via_orthology)	KCNQ2 KCNQ3 KCNQ5 KCNQ4	3.07e-10	10	34	4	DOID:2843 (implicated_via_orthology)
Disease	developmental and epileptic encephalopathy (implicated_via_orthology)	KCNQ2 KCNQ3 KCNQ5 KCNQ4	1.04e-09	13	34	4	DOID:0112202 (implicated_via_orthology)
Disease	heart conduction disease (implicated_via_orthology)	KCNQ2 KCNQ3 KCNQ5 KCNQ4	5.16e-08	32	34	4	DOID:10273 (implicated_via_orthology)
Disease	Benign neonatal seizures	KCNQ2 KCNQ3	1.29e-06	2	34	2	cv:C0220669
Disease	benign neonatal seizures (implicated_via_orthology)	KCNQ2 KCNQ3	1.29e-06	2	34	2	DOID:14264 (implicated_via_orthology)
Disease	benign neonatal seizures (is_implicated_in)	KCNQ2 KCNQ3	3.86e-06	3	34	2	DOID:14264 (is_implicated_in)
Disease	Familial benign neonatal epilepsy	KCNQ2 KCNQ3	1.93e-05	6	34	2	C0220669
Disease	Ischemia	CXCR3 REN	4.78e-04	28	34	2	C0022116
Disease	Alcoholic Intoxication	REN CD19	6.25e-04	32	34	2	C0001969
Disease	diverticulitis	SLC25A38 ADCY6	8.37e-04	37	34	2	EFO_1001460
Disease	beta-nerve growth factor measurement	MIGA1 FASN	1.08e-03	42	34	2	EFO_0008035
Disease	Pneumonia	CXCR3 ABCF1	1.78e-03	54	34	2	C0032285
Disease	Experimental Lung Inflammation	CXCR3 ABCF1	1.78e-03	54	34	2	C0887898
Disease	Pneumonitis	CXCR3 ABCF1	1.78e-03	54	34	2	C3714636
Disease	Lobar Pneumonia	CXCR3 ABCF1	1.78e-03	54	34	2	C0032300
Disease	Bipolar Disorder	KLK8 KCNQ2 KCNQ3 REN	2.13e-03	477	34	4	C0005586
Disease	Allergic Reaction	CXCR3 ABCF1	2.41e-03	63	34	2	C1527304
Disease	Hypersensitivity	CXCR3 ABCF1	2.48e-03	64	34	2	C0020517
Disease	rheumatoid arthritis (is_marker_for)	CXCR3 PGF	2.88e-03	69	34	2	DOID:7148 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
RERMWMLLLRLGCPN	CXCR3	326	P49682
WRMRVSLARALFMEP	ABCF1	456	Q8NE71
KMPVALLRRRMSVWL	ANAPC2	686	Q9UJX6
RTRANSMEGLMPRWV	ADCY6	571	O43306
RGMQRWMLPLRRGAR	C9orf163	156	Q8N9P6
MERMNWLSRLASRGP	FHIP1B	1	Q8N612
RMLRMDRRGGTWKLL	KCNQ3	236	O43525
RMVRMDRRGGTWKLL	KCNQ5	241	Q9NR82
ILRMVRMDRRGGTWK	KCNQ4	211	P56696
LRMIRMDRRGGTWKL	KCNQ2	206	O43526
MSRRSMLLAWALPSL	PGLYRP1	1	O75594
PLADDRSRSLLMWML	NEMP2	261	A6NFY4
ARDMWVMETGLLLPR	CD19	236	P15391
MRMAPTESTEGRRLW	LINC02902	1	Q6ZTY9
MGRPRPRAAKTWMFL	KLK8	1	O60259
PDRRERMLASLWEME	CERCAM	331	Q5T4B2
TQWRGMGLSLMRLDR	FASN	501	P49327
RLFRPWLNMDRMLRS	BCAT2	116	O15382
MARPGMERWRDRLAL	DHRS11	1	Q6UWP2
LMGMELFEEALRRWE	MIGA1	211	Q8NAN2
MAASMARRLWPLLTR	SARS2	1	Q9NP81
WMREFIQLAGRVMLP	VAC14	281	Q08AM6
AFRWMNNLLMRELPL	TBC1D22B	406	Q9NU19
MAGPRPRWRDQLLFM	TMEM140	1	Q9NV12
MDGWRRMPRWGLLLL	REN	1	P00797
DRRLWMEAMDGREPV	ARHGAP26	356	Q9UNA1
MLRTAMGLRSWLAAP	SEMA4B	1	Q9NPR2
GLIRWMLMVNPDRRA	NUAK1	281	O60285
IPRALRRTLMAAMAW	SLC25A38	276	Q96DW6
MAVRSRRPWMSVALG	CHSY3	1	Q70JA7
RRSLPMLFRMEWGCA	PGF	156	P49763
TLPMLPWLMAEIRRR	TBC1D4	51	O60343
ERLWGLTEMFPERVR	TOMM22	46	Q9NS69
MSWYRQDPGMGLRLI	TRBV6-8	51	A0A0A6YYG3
MLPEWLRSRFRMGEL	TRPV3	706	Q8NET8
MSWYRQDPGMGLRLI	TRBV6-5	51	A0A0K0K1A5