Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	CHD9 MCM6 CHD1 DDX3X	8.76e-05	127	37	4	GO:0008094
GeneOntologyMolecularFunction	helicase activity	CHD9 MCM6 CHD1 DDX3X	2.03e-04	158	37	4	GO:0004386
HumanPheno	Motor stereotypy	EHMT1 CACNA1B CHD1 TCF20 WDR4 CERT1	3.23e-05	280	13	6	HP:0000733
Domain	Chromo_domain	CHD9 CHD1	9.18e-04	24	35	2	IPR023780
Domain	Helicase_C	CHD9 CHD1 DDX3X	1.05e-03	107	35	3	PF00271
Domain	HELICc	CHD9 CHD1 DDX3X	1.05e-03	107	35	3	SM00490
Domain	Helicase_C	CHD9 CHD1 DDX3X	1.08e-03	108	35	3	IPR001650
Domain	Chromo	CHD9 CHD1	1.08e-03	26	35	2	PF00385
Domain	HELICASE_CTER	CHD9 CHD1 DDX3X	1.10e-03	109	35	3	PS51194
Domain	HELICASE_ATP_BIND_1	CHD9 CHD1 DDX3X	1.10e-03	109	35	3	PS51192
Domain	DEXDc	CHD9 CHD1 DDX3X	1.10e-03	109	35	3	SM00487
Domain	Helicase_ATP-bd	CHD9 CHD1 DDX3X	1.13e-03	110	35	3	IPR014001
Domain	CHROMO_2	CHD9 CHD1	1.25e-03	28	35	2	PS50013
Domain	CHROMO_1	CHD9 CHD1	1.25e-03	28	35	2	PS00598
Domain	SNF2_N	CHD9 CHD1	1.63e-03	32	35	2	PF00176
Domain	SNF2_N	CHD9 CHD1	1.63e-03	32	35	2	IPR000330
Domain	Chromodomain-like	CHD9 CHD1	1.63e-03	32	35	2	IPR016197
Domain	CHROMO	CHD9 CHD1	1.74e-03	33	35	2	SM00298
Domain	Chromo/shadow_dom	CHD9 CHD1	1.74e-03	33	35	2	IPR000953
Domain	-	GBP1 CHD9 MCM6 CHD1 ABCA13 DDX3X	2.40e-03	746	35	6	3.40.50.300
Domain	P-loop_NTPase	GBP1 CHD9 MCM6 CHD1 ABCA13 DDX3X	4.52e-03	848	35	6	IPR027417
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	EHMT1 CHD9 FLNC RELN TCF20 ZNF532 CLK1 DDX3X CPSF7	1.50e-06	1082	37	9	38697112
Pubmed	METTL3 protects METTL14 from STUB1-mediated degradation to maintain m6 A homeostasis.	FLNC MCM6 CHD1 UBR5 NACA	4.54e-06	231	37	5	36597993
Pubmed	A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.	FLNC UBR5 DDX3X NACA BORA	4.63e-06	232	37	5	25515538
Pubmed	TWIST1 and chromatin regulatory proteins interact to guide neural crest cell differentiation.	CHD9 CHD1 TCF20 UBR5	5.57e-06	109	37	4	33554859
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	CHD9 MIGA1 RELN DCLK2 WDR4 ZNF532 CLK1 DDX3X DOP1B	6.09e-06	1285	37	9	35914814
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MCM6 WDR4 UBR5 DDX3X TUT7 CCSER2	6.61e-06	440	37	6	34244565
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	EHMT1 CHD9 MCM6 CHD1 TCF20 ZNF532 UBR5 CPSF7	9.25e-06	1014	37	8	32416067
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLNC MCM6 CHD1 TCF20 UBR5 DDX3X NACA CPSF7	9.93e-06	1024	37	8	24711643
Pubmed	Proteomic and biochemical studies of calcium- and phosphorylation-dependent calmodulin complexes in Mammalian cells.	UBR5 DDX3X	1.10e-05	5	37	2	17696464
Pubmed	Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.	GBP1 CHD1 CLK1 NACA	2.07e-05	152	37	4	16009940
Pubmed	CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins.	CHD1 CLK1	2.30e-05	7	37	2	12890497
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP31 DCLK2 TCF20 DDX3X TAB3 DOP1B CCSER2	3.00e-05	861	37	7	36931259
Pubmed	Compartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair.	EHMT1 MCM6 UBR5 DDX3X NACA	3.69e-05	357	37	5	37059091
Pubmed	Identification of novel Smad2 and Smad3 associated proteins in response to TGF-beta1.	ZFYVE9 DDX3X CPSF7	4.63e-05	65	37	3	18729074
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	FLNC MCM6 CHD1 TCF20 UBR5 TUT7	6.06e-05	653	37	6	22586326
Pubmed	Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.	CACNA1B CHD9 ABCA13 NACA	7.03e-05	208	37	4	33230847
Pubmed	OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ.	CHD1 TAB3 CPSF7	1.26e-04	91	37	3	30472188
Pubmed	Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.	CACNA1B CHD1 WDR4 CLK1 TUT7	1.73e-04	496	37	5	31343991
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MED12L EHMT1 ZNF532 NACA CCSER2	2.33e-04	529	37	5	14621295
Pubmed	The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery.	FLNC CHD1 TCF20 ZNF532 CLK1 CPSF7 CCSER2	2.41e-04	1203	37	7	29180619
Pubmed	Arginine methylation and ubiquitylation crosstalk controls DNA end-resection and homologous recombination repair.	FLNC DDX3X TAB3 NACA CPSF7	2.81e-04	551	37	5	34728620
Pubmed	Substrate trapping proteomics reveals targets of the βTrCP2/FBXW11 ubiquitin ligase.	FLNC CHD1 BORA	3.45e-04	128	37	3	25332235
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	FLNC MCM6 CHD1 TCF20 UBR5 TUT7 NACA	4.91e-04	1353	37	7	29467282
Pubmed	The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling.	RELN DCLK2	5.35e-04	32	37	2	31315048
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	FLNC RELN NACA CPSF7	5.69e-04	360	37	4	33111431
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	FLNC MCM6 CHD1 TCF20 DDX3X CPSF7	5.70e-04	989	37	6	36424410
Pubmed	SR protein kinases promote splicing of nonconsensus introns.	ABCA13 CLK1 DDX3X CPSF7	5.75e-04	361	37	4	26167880
Pubmed	Gfi1b regulates the level of Wnt/β-catenin signaling in hematopoietic stem cells and megakaryocytes.	EHMT1 UBR5	6.05e-04	34	37	2	30894540
Pubmed	Cdc37 interacts with the glycine-rich loop of Hsp90 client kinases.	DDX3X NACA	6.05e-04	34	37	2	16611982
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	EMC7 UBR5 DDX3X TAB3 NACA	6.26e-04	657	37	5	36180527
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	MCM6 DDX3X TAB3 CPSF7	7.17e-04	383	37	4	29331416
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	GBP1 FLNC MCM6 WDR4 CERT1 DDX3X NACA	7.55e-04	1455	37	7	22863883
Pubmed	Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice.	EHMT1 FLNC	7.96e-04	39	37	2	24703692
Pubmed	Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.	FLNC MCM6 DDX3X NACA CPSF7	8.71e-04	707	37	5	19738201
Pubmed	MITOL regulates phosphatidic acid-binding activity of RMDN3/PTPIP51.	MIGA1 UBR5	8.80e-04	41	37	2	34964862
Pubmed	Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.	EHMT1 DDX3X CPSF7	8.87e-04	177	37	3	26206133
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	USP31 TCF20 UBR5 DOP1B	8.99e-04	407	37	4	12693553
Pubmed	Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor.	FLNC UBR5 DDX3X TAB3	9.08e-04	408	37	4	33766124
Pubmed	A GO catalogue of human DNA-binding transcription factors.	ZNF532 ZNF826P	9.23e-04	42	37	2	34673265
Pubmed	MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1.	MCM6 DDX3X NACA	9.61e-04	182	37	3	30711629
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EHMT1 CHD9 TCF20 UBR5 DDX3X CPSF7	1.01e-03	1103	37	6	34189442
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	CHD1 EMC7 TCF20 TUT7 NACA	1.02e-03	733	37	5	34672954
Pubmed	A Mass Spectrometry-Based Profiling of Interactomes of Viral DDB1- and Cullin Ubiquitin Ligase-Binding Proteins Reveals NF-κB Inhibitory Activity of the HIV-2-Encoded Vpx.	GBP1 DDX3X	1.06e-03	45	37	2	30619335
Interaction	SLX4 interactions	EHMT1 CHD9 MCM6 CHD1 TCF20 UBR5 DDX3X NACA	6.02e-06	572	36	8	int:SLX4
Interaction	OBSL1 interactions	CACNA1B FLNC MCM6 CHD1 TCF20 WDR4 DDX3X TUT7 CPSF7	2.19e-05	902	36	9	int:OBSL1
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	FLNC FAM86B2 ABCA13 TUT7	5.79e-06	142	37	4	191a13bba143ecdfc2bfd797c3ac191481388298
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	FLNC FAM86B2 ABCA13 TUT7	5.96e-06	143	37	4	b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCell	droplet-Spleen-nan-18m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CHD9 CHD1 CLK1 DDX3X	1.54e-05	182	37	4	eeb5dfa4539e9ca5220f26bc2b65717ddcf13b6c
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	GBP1 CHD1 CLK1 DDX3X	2.23e-05	200	37	4	12f1685ce8f218433068e090c9d839cd5a1910bf
Computational	Neighborhood of DDX5	CHD1 DDX3X NACA	1.47e-04	63	18	3	GNF2_DDX5
Disease	Intellectual Disability	MED12L CACNA1B TCF20 WDR4 CERT1 DDX3X	1.10e-05	447	34	6	C3714756
Disease	gastric adenocarcinoma (is_implicated_in)	UBR5 ABCA13	7.04e-05	11	34	2	DOID:3717 (is_implicated_in)
Disease	autism spectrum disorder (implicated_via_orthology)	CHD9 CHD1 TCF20	7.13e-04	152	34	3	DOID:0060041 (implicated_via_orthology)
Disease	ocular hypertension, response to triamcinolone acetonide	CHD9 TUT7	1.46e-03	49	34	2	EFO_0006954, EFO_1001069
Disease	Colorectal Neoplasms	FLNC CHD1 ABCA13	3.95e-03	277	34	3	C0009404
Disease	Epilepsy, Cryptogenic	CERT1 DDX3X	4.04e-03	82	34	2	C0086237
Disease	Awakening Epilepsy	CERT1 DDX3X	4.04e-03	82	34	2	C0751111
Disease	Aura	CERT1 DDX3X	4.04e-03	82	34	2	C0236018
Disease	Neurodevelopmental Disorders	CERT1 DDX3X	5.16e-03	93	34	2	C1535926
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	TCF20 CERT1	6.29e-03	103	34	2	EFO_0008595, EFO_0020944

Protein segments in the cluster

Peptide	Gene	Start	Entry
TKSQSLSYASLKAGS	AKAP4	441	Q5JQC9
TYSGGTKRKLSTALA	ABCA13	4856	Q86UQ4
ASLKSGKTESSSYFR	CACNA1B	451	Q00975
TRNYKALSKGSKGST	CHD1	731	O14646
SSKSSGRSGRSSYKS	CLK1	101	P49759
GFTRKYSLSSKTGTL	RFX6	226	Q8HWS3
KSYSVGASGSSSRKR	CPSF7	406	Q8N684
SGYSATSTSSFKKGH	CERT1	141	Q9Y5P4
SSSKDKDAYSSFGSR	DDX3X	61	O00571
AVYTSGKASSAAGLT	MCM6	416	Q14566
SYLLSSGGSVTLSKS	FAM86B2	111	P0C5J1
LKSSSLAGSYTTGLC	MED12L	866	Q86YW9
LGATKGSSSVYFKTT	DOP1B	1651	Q9Y3R5
LKSSYSRSSAVKYSG	DCLK2	291	Q8N568
SRSSAVKYSGSKSPG	DCLK2	296	Q8N568
KSSSSRGSSYSSIPK	FLNC	2616	Q14315
SYIFSNSKTKTLSGG	GBP1	271	P32455
ISSGSSLYFSKAGKR	RELN	1101	P78509
SLKISCKGSGYSFTS	IGHV5-51	36	A0A0C4DH38
KFTKGTLLGRTSYSS	CCSER2	151	Q9H7U1
PSSKKSDGSGTYTKL	CHD9	486	Q3L8U1
ASAKKYSLGSITSPS	BORA	256	Q6PGQ7
RLFSSKSSGKSSSGS	EMC7	216	Q9NPA0
KPSGALGSESYKSSA	EHMT1	451	Q9H9B1
GLFSKYSGSAQSLAS	MIGA1	156	Q8NAN2
IGSKAVNYSSTGSSK	TMEM106A	26	Q96A25
KGSHKYQRSSSSGSD	TAB3	496	Q8N5C8
ASSLDSYSKDGAKSL	ZNF532	96	Q9HCE3
GKAFTASSTLSEYKT	ZNF826P	126	Q6ZT77
KGSTKYTSLASSANS	TDRP	141	Q86YL5
STSSDTTYKGGASEK	TCF20	541	Q9UGU0
SGAILASTFSKSGSY	WDR4	61	P57081
RGGYTTALKSFTKAS	TTC37	611	Q6PGP7
LTYTASSTSAKKASG	USP31	1121	Q70CQ4
CPQFKGSSGSLSSKY	TUT7	1466	Q5VYS8
KFSSSASYTGAETLG	EDA2R	261	Q9HAV5
SGALKSSSGYLAKSS	ZFYVE9	1206	O95405
SQGLYSSSASSGKCL	UBR5	2071	O95071
GASATASSKGTLTYL	NACA	776	E9PAV3